"""trial"".""trial_id"""	"""trial"".""public_title"""	"""trial"".""recruitment_status"""	"""trial"".""study_type"""	"""trial"".""date_registration"""	"""trial"".""last_refreshed"""	"""trial"".""source_register"""	"""trial"".""id"""	"""trial"".""scientific_title"""	"""trial"".""scientific_title_native"""	"""trial"".""study_design"""	"""trial"".""study_phase"""	"""trial"".""allocation"""	"""trial"".""masking"""	"""trial"".""purpose"""	"""trial"".""date_enrolment"""	"""trial"".""primary_sponsor"""	"""trial"".""secondary_sponsors"""	"""trial"".""web_address"""	"""trial"".""target_size"""	"""trial"".""inclusion_criteria"""	"""trial"".""exclusion_criteria"""	"""trial"".""health_conditions"""	"""trial"".""interventions_summary"""	"""trial"".""contacts_summary"""	"""trial"".""results"""	"""trial"".""countries"""	"""trial"".""updated_on"""
RBR-79fw26y	Transcranial direct current stimulation (tDCS) and augmentative and alternative communication for children with cerebral palsy	Array	Intervention	2024-12-09	<NULL>	<NULL>	7581	Transcranial direct current stimulation and augmentative and alternative communication for children with cerebral palsy: a double-blind, randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-03	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-79fw26y	<NULL>	Diagnosis of cerebral palsy; both genders; age between six and twelve Years; children levels III, IV and V of the communication function classification system; statement of informed consent signed by a legal guardian; statement of informed assent signed by the participant	Children with neurological, neuromuscular diseases or syndromes associated with cerebral palsy; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-3d9kqb	Effect of peanut in appetite and diabetes risk	data analysis completed	Intervention	2011-06-29	<NULL>	<NULL>	8	Acute and second meal effects of peanuts on glycemic response and appetite in obese women a randomized crossover trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Federal de Viçosa	Peanut Collaborative Research Support Program	https://ensaiosclinicos.gov.br/rg/RBR-3d9kqb	<NULL>	Age 18 - 60 years, body mass index  between 30 - 35 kg/m2, not taking medications known to affect glycemia, fat metabolism, or appetite; regular breakfast consumer (?100 kilocalories ingested within 2 hours of waking on ?4d/wk); no body weight fluctuation (&lt;5kg in the past 3 months); willingness to eat all test foods; no self-reported allergy to the foods provided in the study; no self-reported sleep disorders; at least one of the following conditions: waist circumference ? 88 cm; reported family history of type 2 diabetes in first degree relatives; capillary glycemia between 5.5 – 7.0 mmol/L; and/or a 2-hour blood glucose of 7.8 – 11.1 mmol/L (impaired glucose tolerance).	Type 2 diabetes, dyslipidemia or high blood pressure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-4hb6f6	Evaluation of electroacupuncture on the treatment of neck and sholder pain	data analysis completed	Intervention	2011-07-02	<NULL>	<NULL>	10	Evaluation of Electroacupuncture on the myofascial pain treatment of the upper trapezius muscle	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	<NULL>	Faculdade de Odontologia de Piracicaba/UNICAMP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4hb6f6	<NULL>	Female, age range from 18 to 40 years, at least one MTrPs in the upper trapezius muscle, local or referred persistent pain for at least six months, regular menstrual cycles controlled by the use of oral contraceptive, and right-handed.	Accentuated postural abnormalities, verified by the physiotherapist (MFMA), fibromyalgia syndrome, cervical radiculopathy, systemic disease or therapeutic interventions for physical myofascial pain within the past month before the study, pregnancy, chronic pacemaker or electronic implants, the last ones informed by the subject. The continuous use of medications to treat headache and muscular pain was also an exclusion criterion. Moreover, if evident cognitive impairment or communication difficulties were observed by the examiner (MFMA) at the first meeting, the subject was not included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-5gvsgp	Outpatient Treatment of Patients with abnormal scars.	data analysis completed	Intervention	2011-09-07	<NULL>	<NULL>	23	Outpatient Treatment of Keloids in patients treated in Juiz de Fora - MG. 2010.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Presidente Antônio Carlos - Faculdade de Medicina de Juiz de Fora	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5gvsgp	<NULL>	We included all patients seen in primary routing path followed in an initial consultation and in their returns during treatment. We interviewed 62 patients with an interest in treating keloids as outpatients, but only 43 agreed to participate and signed an informed consent.	The patients who refused treatment, who denied signing the consent form during the initial consultation were eliminated from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6pq736	Oral Care and Pneumonia in Institutionalized Elderly	data analysis completed	Intervention	2011-09-07	<NULL>	<NULL>	24	Efficacy of Oral Hygiene Practices on Aspiration Pneumonia Oral Pathogens in Elderly Nursing Home Residents	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Federal do Espírito Santo	Maria Cecilia Azevedo de Aguiar	https://ensaiosclinicos.gov.br/rg/RBR-6pq736	<NULL>	Being elderly (older than 60 years old) and to live at the long-term care facility selected for the research	Diagnosis of neoplastic or infectious disease during the study stages; Inability to breathe or feed by natural means (dependence on mechanical ventilators or feeding tubes); Need for antimicrobial therapy or hospitalization in the three months prior to intervention; Dependence on immunosuppressive drugs; Diagnosis of Sjögren&apos;s syndrome; Persons who had received radiotherapy with irradiation field covering the head and neck.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-48x3xv	Comparative study of the influence of blood flow, oxygenation and hemodynamics generated during the use of extracorporeal circulation machine	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	25	Comparison of the influence of two blood flow patterns generated by cardiopulmonary bypass pump in oxy-hemodynamic markers  during cardiopulmonary bypass	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Instituto Nacional de Cardiologia	Maria aparecida Nogueira de Lima Marcondes Salgado	https://ensaiosclinicos.gov.br/rg/RBR-48x3xv	<NULL>	Patient admitted to the National Institute of Cardiology,  which have coronary heart disease and were referred for surgery for isolated primary CABG, patients with ejection fraction greater than or equal to 45%, both sexes; aged between 18 and 75 years, during cardiopulmonary bypass use of vacuum-assisted venous drainage and use of normothermia during cardiopulmonary bypass	Patient admitted to the National Institute of Cardiology, which appear as disease and / or diagnosis associated with surgery, recent myocardial infarction (less than 3 months), recent stroke (less than 3 months, unstable angina, urgent or emergency surgery, diabetes mellitus decompensated - disease of diabetic ketoacidosis, renal failure - creatinine clearance &lt;30 ml / min	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-32ym5t	Electrical stimulation in healthy individuals	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	26	Interferencial current produce peripheral vasodilation in healthy individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade de Brasília	Hospital das Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-32ym5t	<NULL>	Individuals of both sexes, with age group from 19 to 44 years, non-smokers, non-obese and free of any signs or symptoms of disease, as revealed by the medical history, physical examination and electrocardiogram at rest and during exercise	Pregnancy, breastfeeding, alcohol or drug abuse and any medication with potential effects on the circulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-5j32mm	The exercises for the pelvic muscles improves female orgasm?	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	27	Effect of kinesiotherapy in the contractility of pelvic floor in women with orgasmic dysfunction: electromyographic evaluation.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Estadual de Campinas - UNICAMP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5j32mm	<NULL>	"Women aged between 18 and 40 years old;
With sexually active, regular partner at least one year;
Use oral contraceptives
No symptoms of urinary / fecal incontinence;
Domain orgasm FSFI with a score &lt;3.0 (which features the orgasmic dysfunction, according to the instrument);
Coefficient of orgasmic capacity - COC &lt;1 (low orgasmic capacity, according to the instrument);
Force of contraction of the pelvic floor compromised."	"Peripheral or central neurological disorders;
History of pelvic floor muscle training;
History of any treatment for sexual dysfunction;
Presence of symptoms of urinary / fecal incontinence;
Reporting of clinical diagnosis: vaginismus, type III and IV prolapse, diabetes, dislipedemias; menopause or menopause, hypertension, depression;
Reporting of primary anorgasmia (never had an orgasm);
Pregnant women;
More than three pregnancies and / or three births;
Have the orgasm domain scores &gt;3.0; high orgasmic capacity (CCO &gt; 1);
Without compromising the strength of contraction of the pelvic floor;
Patient has not achieved 75% of the proposed therapy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-8jgwpr	Effects of noninvasive ventilation after cardiovascular surgery: A Randomized Clinical Trial	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	28	Effects of noninvasive mechanical ventilation on the hemodynamic and ventilatory parameters in post-cardiac surgery patients who developed hypoxemia after tracheal extubation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-01	Alessandra Preisig	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (UFRGS)	https://ensaiosclinicos.gov.br/rg/RBR-8jgwpr	<NULL>	"Postoperative cardiovascular surgery (valve replacement, thoracoabdominal aortic surgery and/or coronary artery bypass graft (CABG);
Sternal incision and pulmonary artery catheter from surgical ward 
Both genders, aged between 18 and 80 years."	"Severe chronic obstructive pulmonary disease,
Previous neurological disease and inability to understand;
More than 24 hours on mechanical ventilation;
Surgical revision for bleeding after tracheal extubation;
Emergency surgery;
Swan-Ganz catheter nonfunctioning"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2qxmd9	Strengthening exercises for strength and ability to manipulate objects in people with rheumatoid arthritis in the hands.	data analysis completed	Intervention	2011-09-25	<NULL>	<NULL>	29	Strengthening exercises for hand muscles to increase strength and improve functionality in individuals with rheumatoid arthritis hand deformities.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-07-01	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital de Clínicas da FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-2qxmd9	<NULL>	Women diagnosed with rheumatoid arthritis  and presenting deformity in at least one of the fingers of each hand participated voluntarily in the present study. Each hand should present at least one of the following deformities: swan neck, boutonniere finger and Z-shaped thumb. Deformities as bouchard&apos;s nodules and ulnar deviation should be obligatorily present in both hands.	Women presenting other rheumatoid arthritis -related diseases and/or who entered the exacerbation phase (symptoms of inflammation in the hand joints) during the experimental time were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6qs4tb	Effects of treadmill training with partial body weight support and the one physical therapy method on gait of patients with stroke	data analysis completed	Intervention	2011-11-09	<NULL>	<NULL>	34	Analysis of the effectiveness of treadmill training with partial body weight support and the Proprioceptive Neuromuscular Facilitation method on the hemiparetic gait due to stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Ana Raquel Rodrigues Lindquist	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6qs4tb	<NULL>	The sample was composed of men and women, aged between 40 and 70 years, with chronic hemiparesis following unilateral and non-recurring stroke, with spasticity classified between levels 0 and 2 on the Modified Ashworth Scale of muscle spasticity for the lower limb affected; ambulatory capacity classified between levels 3 and 5 on the Functional Ambulatory Category; minimum sequel time of 6 months; absence of clinical signs of cardiac alterations (New York Heart Association, degree I); absence of other orthopedic or neurological impairment that caused gait alterations; ability to walk 10m without assistive devices; not using orthotics on the paretic lower limb; and capacity to obey simple verbal commands.	Exclusion criteria were individuals whose heart rate exceeded 75% of age-adjusted maximum heart rate and those who had fear of falling while walking on the treadmill.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3bms6f	Sitting posture and changes in respiratory function	data analysis completed	Observational	2011-11-13	<NULL>	<NULL>	35	Sitting position and respiratory function in two significantly different chair-table system	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-05	Universidade de São Paulo	Laboratório de Fisioterapia e Comportamento da FMUSP	https://ensaiosclinicos.gov.br/rg/RBR-3bms6f	<NULL>	Female university students, aged between 18 and 25 years, regularly enrolled in a public University, healthy, Caucasian, right-handed, sedentary, with body mass index between 18.5 to 24.9 kg/m2	Diseases of the respiratory system or musculoskeletal system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-4mxksj	Study on the benefit of the use of protocols in the care of chest pain in emergency physicians of the Cardiology Institute of Santa Catarina	data analysis completed	Intervention	2011-12-14	<NULL>	<NULL>	38	Compliance assessment to the Recommendations of the Corporate Guidelines through a Protocol Approach to Acute Coronary Syndrome by residents in the Emergency Room of Cardiology Institute of Santa Catarina: a Cluster Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-01	Instituto de Cardiologia de Santa Catarina	Instituto de Cardiologia de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4mxksj	<NULL>	All eight residents of Instituto de Cardiologia de Santa Catarina will be included in the study.	Residents who do not agree to sign the term of consent form (free and clear).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2xgjh3	Physical performance in older adults after exercise program	data analysis completed	Intervention	2011-12-05	<NULL>	<NULL>	40	A proposal for intervention through exercise for the elderly: implications for physical fitness and functional hability	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-06-08	Universidade de Fortaleza	Wilson Max Almeida Monteiro de Moraes	https://ensaiosclinicos.gov.br/rg/RBR-2xgjh3	<NULL>	People who belong to the group of elderly Community Center Luiza Tavora, aged 60 years or over, physically independent, of both genders and voluntarily consent to participate	Failure to understand instructions, due to some cognitive problem, the dependence on a wheelchair, crutches or apparatus to walk or need help to remain standing; paralysis in one end of the arms or legs, uncontrolled high blood pressure (&gt; 160 / 100mmHg) before testing and reports of chest pain or dizziness, trouble bone / joint / muscle or some other condition that would preclude participating in previous motor tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-6ynv5y	Posture and mobility in adolescents federated in basketball.	data analysis completed	Observational	2012-01-04	<NULL>	<NULL>	43	Postural and mobility characterization of adolescent basketball athletes.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade de São Paulo	Fundação de Amparo para a pesquisa do estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ynv5y	<NULL>	The inclusion criteria was based on adolescents aging between 12 to 16, male adolescents. The athlete group was federated exclusively to basketball (at least 10 hours per week).	The exclusion criteria was based on orthopedic, respiratory, rheumatic and neuromuscular diseases. And the athletes shouldn’t be federated to another sport.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-5g7xqh	Effects of acupuncture on muscle strength of healthy subjects and stroke patients	data analysis completed	Intervention	2011-10-26	<NULL>	<NULL>	50	Immediate effects of manual acupuncture on the biceps brachii muscle function in healthy subjects and chronic hemiparetic patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-12	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-5g7xqh	<NULL>	"Control group: Absence of pain, trauma or musculoskeletal injuries in the upper limbs, neuromuscular diseases, pregnancy or some sort of unconfortable reaction to needling; Informed written consent signature after reading of the text and explanation of the objectives, risks and potential benefits from the participation in this research.
Hemiplegic group: Clinical diagnosis of upper neuron lesion due to stroke for at least 6 months, confirmed by image exams, both ischemic of hemorragic; Partial motor impairment of the upper limb function (hemiparesis); Absence of pain, trauma or musculoskeletal injuries in the upper limbs, neuromuscular diseases, pregnancy or some sort of unconfortable reaction to needling; Informed written consent signature after reading of the text and explanation of the objectives, risks and potential benefits from the participation in this research."	Incomplete realization of any electromyographic signal acquisition; Low quality of electromyographic signal (less than 2-out-of-3 visible contraction events).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-59f4yr	Effect of acupuncture on anxiety in infertility women	data analysis completed	Intervention	2012-01-04	<NULL>	<NULL>	52	Effect of acupuncture on anxiety in women undergoing to in vitro fertilization	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-01	Serviço de Reprodução Humana - Faculdade de Medicina do ABC	Serviço de Reprodução Humana - Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-59f4yr	<NULL>	Women newer than 45 years, without previous psychiatric disorders, without use of antidepressants and / or anxiolytics and without use of acupuncture before.	Women older than 45 years, previous psychiatric disorders, use of antidepressants and / or anxiolytics and use of acupuncture before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2h3d6b	Effect of nebulized saline on mucociliary transport	data analysis completed	Intervention	2012-01-04	<NULL>	<NULL>	57	Effect of Nebulisation on the Mucociliary Nasal Transport	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Faculdade de Medicina de Ribeirão Preto	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2h3d6b	<NULL>	Volunteers aged between 18 and 30 years old were selected amongst the Ribeirão Preto School of Medicine undergraduate and post-graduate students for study	Those with smoking habits, cystic fibrosis, sinusitis, rhinitis, ciliary dyskinesia, hypertrophy of lower turbinates, major septal deviation, upper and lower airways infections in the last four weeks prior to study, bronchiectasis, and individuals who underwent surgery in the upper airways were excluded from study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7jq63n	Effect of physical conditioning in patients with spinal cord injury to improve physical endurance.	data analysis completed	Intervention	2012-01-26	<NULL>	<NULL>	64	Effectiveness of aerobic physical training for prevention and treatment of chronic asymptomatic bacteriuria in subjects with spinal cord injury: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7jq63n	<NULL>	Subjects with spinal cord injury between C5 and L2 segments according to the classification of American Spinal Injury Association (ASIA).	individual practitioner of regular physical activity, community ambulators, unable to ride the cycle ergometer with the arms and those who refuse signing the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-4xrgxs	Energy expenditure and cardiovascular response of gait in traumatic lower limb amputees	data analysis completed	Observational	2012-01-31	<NULL>	<NULL>	69	Analysis of energy expenditure and cardiovascular responses while gait in amputees	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-08	Faculdade de Educação Física da Universidade Federal de Juiz de Fora	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4xrgxs	<NULL>	We studied 30 male subjects, 20 with lower limb amputations (10 transfemoral amputees and 10 transtibial amputees) and 10 non-amputee subjects (control group). For the sample, amputees should have been aided more than two years, to walk without gait aids, prostheses using lined with dynamic Sach ® foot and transfemoral, knee own mechanic. All subjects evaluated should not have hypertension, cardiovascular disease, or any pathology that could alter the quality of gait.	All subjects evaluated should not have hypertension, cardiovascular disease, or any pathology that could alter the quality of gait.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-5fybg2	Investigation of the effect of the consumption of the soluble fiber on the serum cholesterol levels and fractions in children and adolescents.	data analysis completed	Intervention	2012-01-31	<NULL>	<NULL>	70	Investigation of the effect of psyllium in the process of atherosclerosis juvenile	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Laboratório de Erros Inatos do Metabolismo-  Universidade Federal do Pará	Hospital universitário Pedro Ernesto/UERJ	https://ensaiosclinicos.gov.br/rg/RBR-5fybg2	<NULL>	Inclusion criteria: Children and adolescents (6-19 years) that had a fasting plasma total cholesterol over 170mg/dL (4,40 mmol/L) or LDL-cholesterol over 110mg/dL (2,84 mmol/dL) concentrations, same after were treated initially with similar diet the National Cholesterol Education Program step 1 diet (saturated low-fat diet (&lt;10% calories total) and cholesterol (&lt; 300 mg/dia), for at least eight weeks. The subjects were all outpatients of the Pediatric Nutrition Division and Adolescent Health Studies Nucleus of the Pedro Ernesto University Hospital in Rio de Janeiro, and only those subjects that signed an Informed Consent Form could participated the study.	"Patients with cardiovascular diseases or  or other chronic medical conditions were excluded from the study, as were those whose diabetes.
Children and adolescents with triacylglycerol concentrations of over 3.39 mmol/L or whose Body Mass Index (BMI) according age was higher than 30 kg/m² or female pregnant were also excluded. 
Participants were taking lipid-lowering agents, including hypolipemiant functional foods were also excluded the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-5tmjnd	Effect of physical conditioning in patients with spinal cord injury to increase physical resistance.	data analysis completed	Intervention	2012-01-31	<NULL>	<NULL>	71	Effectiveness of aerobic physical training applied to patients with spinal cord injury to increase oxygen consumption.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5tmjnd	<NULL>	Individuals with SCI between segments C5 and L2 according to the classification of the American Spinal Injury Association	Individuals who do regular physical activity, community ambulators and individuals who were unable to pedal the cycle ergometer with their arms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-993wz5	High-voltage pulsed current (HVPS) promotes cicatrization of chronic cuaneos ulcers	data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	73	Effect of Hight Voltage Pulsate Current on chronic cutaneous ulcers treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	<NULL>	Faculdades Integradas Einstein de Limeira	Faculdades Integradas Einstein de Limeira	https://ensaiosclinicos.gov.br/rg/RBR-993wz5	<NULL>	Inclusion criteria was considered both genders, aged between 18 and 80 years and the presence of chronic cutaneos ulcers of any etiology and that no contamination	The presence of wound infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-68zp3c	Effects of a physical therapy technique on the feet on the balance of elderly	data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	76	Immediate effects of mobilization of the talocrural joint on the static and dinamic balance of elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-04	Universidade Metodista de Piracicaba	Adriana Pertille	https://ensaiosclinicos.gov.br/rg/RBR-68zp3c	<NULL>	"Age between 65 and 80 years; 
Male or female;
Walking without assistive devices for walking;
Normal skin sensitivity in the ankles and feet;
Without cognitive impairment."	"Amputation or use of prosthetic;
Neurological sequelae; 
Fractures in the lower limbs or spine after age 65; 
Severe coronary artery disease;
Labyrinth disease;
Diagnosed neuropathy and foot deformity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-64wczh	Imipramine compared to conservative treatment of urinary incontinence in women urgency.	data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	77	Imipramine versus conservative treatment in women with Overactive Bladder Syndrome.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2010-05-01	Hospital de Clínicas de Porto Alegrte - HCPA	Hospital de Clínicas de Porto Alegrte - HCPA	https://ensaiosclinicos.gov.br/rg/RBR-64wczh	<NULL>	Women older than 18 years, complaining of urge incontinence or mixed (with a major component of emergency)	Pelvic surgery for correction of urinary incontinence less than two years, presence of vaginal or urinary infection, can not understand or sign the informed consent; not understand or are unable to perform the proposed treatment, pregnancy or the postpartum period including the period of six months after delivery; intolerance to the use of imipramine; Urinary Incontinence Mixed Incontinence pure or predominant component of the effort, heart disease, severe liver disease, severe kidney disease with loss of renal function, hyperthyroidism, acute angle glaucoma, epilepsy disease; Parkinson&apos;s disease, uncontrolled hypertension, patients with a history of alcohol or drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8zdzkk	Performance evaluation of individuals after stroke and its correlation with the ability to throw weight to the affected side	data analysis completed	Observational	2012-01-31	<NULL>	<NULL>	81	Analysis of functional performance and its correlation with the weight transfer in hemiparetic individuals	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-05-10	Universidade Estadual Paulista Júlio de Mesquita Filho	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8zdzkk	<NULL>	"We included individuals who had independent gait;
Ischemic or hemorrhagic stroke in any territory evidenced by computed tomography (CT);
Age above 30 and below 65 years;
Have hemiplegia or hemiparesis resulting from single and unilateral stroke."	"Cognitive impairment;
Neurological deficit in addition to hemiparesis from stroke;
Osteoarticular complications (fractures, deformities or ankylosis structured;
Time of injury in excess of twelve months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-5qffrt	Treadmill walking in subjects with Parkinson&apos;s disease	data analysis completed	Intervention	2012-02-02	<NULL>	<NULL>	82	Effects of treadmill walking training with additional body load in subjects with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5qffrt	<NULL>	"Idiopathic Parkinson&apos;s disease, diagnosed by a neurologist experienced in movement disorders, according to the criteria of brain bank in London;
Both sexes aged over 40 and less than 75 years;
In the moderate stage of disease (stages 2 and 3, according to the disability scale of Hoehn and Yahr modified) Use of antiparkinsonian medication;
Walk without any brace or assistive device to walk independently, a walkway of 8 meters (m);
Absence of other neurological disorders, musculoskeletal, cardiovascular and / or breathing that prevent treadmill gait training;
No visual changes and / or uncorrected hearing, that might interfere with the implementation of the Protocol;
Absence of severe cognitive impairment that prevented understanding of simple verbal instructions, as detected by the mini mental state examination;
Not having been subjected to surgery extereotáxica;
Signing the consent form (ICF)."	"Blood pressure (SBP) and systolic and diastolic values above, respectively, 200 mmHg and 110 mmHg before and / or after training;
Heart rate (HR) above the permitted submaximal values, calculated by formula [FCsub = 0.75 x (220 - age)];
Change in dose and / or the type of antiparkinsonian medication during the training period;
Presence of pain and / or severe muscle fatigue that prohibits continued the exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-249vpp	Comparison between the analgesics ketoprofen and parecoxib for pain control after gallbladder surgical removal	data analysis completed	Intervention	2012-02-13	<NULL>	<NULL>	85	Postoperative analgesia: comparison between ketoprofen and parecoxib in patients submitted to conventional cholecystectomy	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-01-10	Pontifícia Universidade Católica de Campinas - PUCCAMP	Pontifícia Universidade Católica de Campinas - PUCCAMP	https://ensaiosclinicos.gov.br/rg/RBR-249vpp	<NULL>	Physical status ASA 1 or 2 patients, undergoing conventional cholecystectomy, of both genders, aged 18 to 55 years old.	"ASA Physical Status 3, 4 or 5.
Patients using hormonal or nonhormonal anti-inflammatory drugs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-6kcc3w	Eteitos training on ramps on the walking pattern of individuals who have suffered stroke	data analysis completed	Intervention	2012-03-30	<NULL>	<NULL>	92	Effects of gait training on sloping surfaces in the gait of individuals with chronic hemiparesis - randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal do Rio Grande do Norte- UFRN	Universidade Federal do Rio Grande do Norte- UFRN	https://ensaiosclinicos.gov.br/rg/RBR-6kcc3w	<NULL>	Time after stroke: more than six months, One-sided hemiparesis,No heart disease, No orthopedic impairment or other neurological impairment that may change the gait, Can mind simple verbal commands, Can wlak anlone or with canes and have being classified by functional ambulation category (FAC) at levels 3 to 5, Spasticity  dagreemild to moderate  in the affected lower limb with levels of classification between 0 and 2 in the Ashworth spasticity scale modified,  70 years Maximum age.	Heart frequency increase more than 75% of the maximum or have any other general instability  during training that may mean risk for the same practice, Lack of training sessions to more than two, when they are consecutive, or more than three, when they are changed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-7bqxm2	Expenses and benefits  of a physical activity program in chronic obstructive pulmonary disease	data analysis completed	Intervention	2012-06-18	<NULL>	<NULL>	95	Assessment of costs and benefits of a physical activity program for Chronic Obstructive Pulmonary Disease: implementation and Primary Care Units in the SUS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-06	Universidade Federal  do Rio Grande do Norte - UFRN	Universidade Federal  do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-7bqxm2	<NULL>	"In medical treatment by a pulmonologist;
 Age between 40 and 85 years;
 Do not make use of oxygen;
 No exacerbations in the last three months;
 Do not be practicing regular physical activity over the past six months."	"Musculoskeletal comorbidities that interfere in the running;
 Decrease the peripheral oxygen saturation (SpO2) &lt;90% during the submaximal exercise test;
 Difficulty in understanding intellectual who prevented them from carrying out the assessment activities;
 Abandoning the practice of physical activity proposed;
 Did not attend for reassessment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-3x57fj	Analgesic and adjuvant anesthetic effect of tramadol after third molar surgery	data analysis completed	Intervention	2012-05-17	<NULL>	<NULL>	97	Postoperative analgesia and  anesthetic effect of local tramadol chloridrate injection after oral surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-02	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3x57fj	<NULL>	Both gender, above 18 years of age, necessity of removal of inferior impacted third molars, symetric and bilateral	"In use of analgesic or anti-inflammatory drugs before 24 hours treatment, history of seizure, pregnancy, 
lactation, history of psychiatric illness, allergy to the drugs used in this study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-8fs5ww	Comparison between two molding techniques in removable partial dentures	data analysis completed	Intervention	2012-11-09	<NULL>	<NULL>	104	A clinical study comparing the technique of forming functional model changed and direct functional impression technique for removable partial dentures free distal end	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-26	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8fs5ww	<NULL>	The Patients must have been rehabilitated in the clinic of the Department of Dentistry degree UFRN be carriers of Removable Prosthodontics Total Upper arch and Removable Partial Denture Lower arch with bilateral posterior free end (Kennedy Class I). The minimum age required to participate in the study will be 18 years and included patients of both genders.	Patients with weakened health care unable to attend; patients with normal classification according to bone height that have less than five or more than eight lower teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-49sk2j	Evaluation of progressive air trapping during exercise in pacients with lymphangioleiomyomatosis and response to bronchodilator	data analysis completed	Intervention	2012-01-31	<NULL>	<NULL>	108	Evaluation of dynamic hyperinflation in patients with lymphangioleiomyomatosis (LAM) using cardiopulmonary exercise testing and study of response to bronchodilator	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2010-01-06	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-49sk2j	<NULL>	"All patients followed in the outpatient setting of pulmonary division of Hospital das Clinicas - University of Sao Paulo Medical School, with the following inclusion criteria:
1) Diagnosis of LAM (clinico-radiological or histological) 
2) Absence of instability (no exacerbation or hospitalization, for pneumothorax or chylothorax, for example, in the last 6 weeks)"	"Previous lung transplant
Muscular or bone disorder who prevents performing exercise
Serious or unstable cardiopathy (functional class IV)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-73vbv8	Physiotherapy in patients of abdominal surgery.	data analysis completed	Intervention	2012-12-20	<NULL>	<NULL>	109	Effects of preoperative physiotherapy in cardiorespiratory conditions and physical functioning of patients undergoing upper abdominal surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-10-27	Pontifícia Universidade Católica de Campinas	Silvia Maria de Toledo Piza Soares	https://ensaiosclinicos.gov.br/rg/RBR-73vbv8	<NULL>	"Patients with over 40 years of age.
Scheduling of upper abdominal surgery elective (including surgery of  esophagus, stomach or biliary tract surgery).
Patients in preoperative elective period, at least 15 days and up to 21 days in advance of surgery.
Physical and mental conditions that permit the evaluation of pulmonary function and walking test acceptable before surgery.
Patients who signed an informed consent forms."	"Patients with cerebrovascular or neuromuscular disease.
Patients on immunosuppressive therapy before surgery.
Prior pulmonary surgery history.
Patients that had previously undergone surgery of the esophagus, stomach or biliary tract.
Cardivascular instability.
Patients undergoing physiotherapy in the eight weeks before inclusion in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-24t799	Effect of cleaning teeth in the levels of c-reactive protein in the blood of patients with severe disease in teeth and bone of the maxilla and mandible	data analysis completed	Intervention	2012-09-28	<NULL>	<NULL>	110	Effect of nonsurgical periodontal therapy on levels of c-reactive protein in serum of subjects with severe periodontitis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-12	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-24t799	<NULL>	Subjects with periodontitis; Periodontitis group: 19 women, nine men; with at least 18 teeth in upper or lower dental arch; be aged a minimum of 20 and maximum of 45 years; no radiographic evidence of bone loss.	History of smoking; pregnancy or lactation; periodontal therapy; antimicrobial therapy for systemic conditions or use of topical oral antibiotics in the last twelve months; diabetes; autoimmune disease; active acute infections; active severe allergies; active gastrointestinal diseases; active renal diseases; active cancer; morbid obesity (Body mass index -BMI-  &gt;40 kg/m2) or underweight (malnourished BMI &lt;18.5 kg/m2); use of medications in the last twelve months that alter the levels of inflammatory mediators.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-6ck4gv	Effects of an exercise program in patients with sequelae of stroke	data analysis completed	Intervention	2012-07-09	<NULL>	<NULL>	111	Effects of Square Stepping Exercise in patients with sequelae of stroke	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp	Centro Universitário Hermínio Ometto - uniararas	https://ensaiosclinicos.gov.br/rg/RBR-6ck4gv	<NULL>	Age 50 to 80 years, unilateral cerebrovascular lesions, and only 12 months before the start of the intervention, supported by computed tomography or magnetic resonance imaging of the brain, ability to understand verbal instructions and ability to walk without assistance or with prosthetic or orthoses (canes, crutches)	Orthopedic and neurological disorders prior stroke and clinical instability associated with severe systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-7nqxy5	Evaluation of the ability of different methods and measures in critically ill patients to check the possibility of withdrawal of mechanical ventilation	data analysis completed	Intervention	2012-06-18	<NULL>	<NULL>	115	Serial measurements before and after extubation of the index of rapid shallow breathing as a predictor of extubation failure in patients on prolonged mechanical ventilation	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7nqxy5	<NULL>	"All patients admitted to the ICU during the period of the study;
Largest 18 years;
In use of the orotracheal tube over 72 h;
In process of weaning from mechanical ventilation;"	"Patients with a history of tracheal or laryngotracheal;
Patients tracheotomized;
Patients extubated accidentally;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-7tf6tm	Treatment of the lower limb pain, which arise during the walks, for lack of circulation. Through temporary circulation interruption of upper limbs.	data analysis completed	Intervention	2012-06-28	<NULL>	<NULL>	118	Remote ischemic preconditioning in patients with intermittent claudication	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tf6tm	<NULL>	this study recruited patients complaining of typical intermitent claudication (IC) in one or both lower limbs, associated with absence or reduction of arterial pulses in the symptomatic member and/or ankle-brachial index &lt; 0.90. Physical examination of the upper limbs was normal in all study participants.	"Arterial occlusion of both upper
 Presence of critical ischemia of lower limbs, characterized by pain at rest or ischemic ulcerations existence of the same.
 Inability to perform the treadmill test for reasons other than the intermittent claudication, as changes rheumatologic, orthopedic, neurological, cardiac or respiratory
 Having used the following drugs in the last two hours before inclusion in the study: cilostazol, sildenafil, dipyridamole, glibenclamide, aminophylline, nicorandil, phenylephrine, angiotensin-converting enzyme inhibitors, angiotensin receptor blocker II, statins, alcohol, steroids, red wine.
 Having consumed a quantity of coffee that means a caffeine intake ? 4mg/kg (approximately 400 ml of coffee brewed in coffee maker) in the last two hours prior to study entry"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-4bxdhb	Prevention of nausea and vomiting after surgery for stomach reduction in obese individuals.	data analysis completed	Intervention	2012-06-05	<NULL>	<NULL>	120	Prevention of nausea and vomiting in obese patients undergoing laparoscopic bariatric surgery: A comparison between three schemes.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-4bxdhb	<NULL>	"Patients aged between 18 and 65 years;
 Obese patients with body mass index (BMI) greater than or equal 35 kg/m2;
 Classified as physical status I-III of the American Society of Anesthesiologists (ASA); 
 Candidates for bariatric surgery, like laparoscopic sleeve gastrectomy under balanced general anesthesia"	"Hypersensitivity or contraindication to study drugs;
Serious complications in the perioperative period; 
Psychiatric disorder and a history of migraine;
Used opóide, anti-inflammatory hormone and anti-emetic medication 24 hours prior to surgery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-6j2vvr	Assessment of static balance in lower limb amputees	data analysis completed	Observational	2012-06-15	<NULL>	<NULL>	121	Static stability evaluation in subjects with unilateral transtibial amputation traumatic.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6j2vvr	<NULL>	"Amputees prostheses for more than one year and not amputated;
Ability to walk without assistive devices for walking;
Use prosthesis aligned with dynamic Sach ® foot."	Hypertension, cardiovascular disease, or any condition that alters the quality of gait.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-2bc4gk	Use of horses on improvement functional capacity of elderly	data analysis completed	Intervention	2012-05-28	<NULL>	<NULL>	124	Hippotherapy on functional capacity of elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Faculdade de Educação Física Universidade de Brasília-UnB	Instituto Cavalo Solidário	https://ensaiosclinicos.gov.br/rg/RBR-2bc4gk	<NULL>	"Ability to understand simple commands; Perform activities of daily living independently; 
Mount the horse independently (with help of the platform mount)
Submission of a medical certificate to practice the activity of riding a horse"	"Body weight greater than 90 kg, 
The animal Phobia"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-8v3tkq	Clinical trial to evaluate the effectiveness and safety of the laser to control the pain caused by orthodontic treatment	data analysis completed	Intervention	2012-05-28	<NULL>	<NULL>	125	Evaluation of low level laser terapy(LLLT) for the treatment of pain associated with positioning elastomeric orthodontic interdental separators	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-06-28	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-8v3tkq	<NULL>	"Chronological age greater than 12 years; 
Presence of erupted permanent first and second lower molars; Presence of erupted first and second premolars; 
Voluntary participation in the study confirmed by signing the informed consent form."	"Patients using antibiotics or analgesics; 
Pregnant or breastfeeding women; 
Patients with cardiac disease; 
Systemic diseases; 
Contraindications for NSAIDs use; 
Surgical procedure during the preceding two weeks; 
Gastrointestinal illness (gastritis, gastric ulcer, lactose intolerance, chronic diarrhea or intestinal inflammatory illness); 
Melanin pigmentation in the gingiva in the area to be irradiated;
Treated or untreated apical bone lesions; 
Diastema in the region of the molars and/or premolars."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-6w9nfq	Effects of the combination of visual or auditory cues to treadmill gait training of individuals who have suffered stroke	data analysis completed	Intervention	2012-05-11	<NULL>	<NULL>	128	Influence of biofeedback in gait training on a treadmill with partial body weight support in hemiparetic subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-6w9nfq	<NULL>	"Chronic stage of stroke (time of injury over 6 months); 
Hemiparesis; unilateral brain lesion and non-recurring, mild to moderate spasticity, with level 1 or 2 of the modified Ashworth scale;
Ability to ambulate functionally, with some assistance or personal with the use of assistive devices for walking, levels 4 and 5 of the protocol Functional Ambulation Category - FAC; 
Idling (slower than 0.4 m / s) or moderate (speed from 0.4 to 0.8 m / s) according to the classification of gait based on speed;
Absence of cognitive impairment, from the score of the Mini Mental State Examination (MMSE);
Absence of other neurological or orthopedic pathologies that lead to functional sequelae than those brought by stroke or disability visual and/or hearing loss that adversely affects the training of biofeedback."	"Instability in the cardiovascular condition during training;
Lack of understanding of instructions for carrying out training"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-27rmv3	Effect of mirror therapy in upper limb of young individuals with cerebral palsy and cerebral vascular accident	data analysis completed	Intervention	2012-05-08	<NULL>	<NULL>	131	Effects of mirror therapy in upper limbs of young individuals with hemiparesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-25	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-27rmv3	<NULL>	"Dysfunctional diagnosis of hemiparesis with brachial predominance; 
Medical diagnosis of Cerebral Palsy or Cerebral Vascular Accident, of prenatal or perinatal etiology; 
Age between 15 and 25 years;
Normal cognitive function."	"Visual and/or hearing impairment;
Mental deficiency; 
Muscular contractions that unable the execution of the tests;
Muscle tone of affected upper limb equal to or greater than 3 in the Ashworth Scale; 
Botulinum toxin  injections and/or surgery during the previous 6 months;
Subjects who do not accomplished 25% or more of the intervention sessions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-58yq52	Acupuncture in Multiple Sclerosis	data analysis completed	Intervention	2012-04-16	<NULL>	<NULL>	132	Impact of electroacupuncture on quality of life for patients with Relapsing-Remitting Multiple Sclerosis under treatment with immunomodulators	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Departamento de Clinica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas - UNICAMP	Juan G. Quispe-Cabanillas	https://ensaiosclinicos.gov.br/rg/RBR-58yq52	<NULL>	Patients with a confirmed diagnosis of RRMS according to the revised 2005 McDonald criteria and under treatment with immunomodulatory drugs (interferon-beta and glatiramer acetate) were selected.	Those individuals who had previously received acupuncture treatment were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-63xvgf	Analysis of low level laser therapy in the treatment of patients with fibromyalgia	data analysis completed	Intervention	2012-05-10	<NULL>	<NULL>	134	Analysis of low level laser therapy in the treatment of patients with fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade do Vale do Paraíba - UNIVAP	https://ensaiosclinicos.gov.br/rg/RBR-63xvgf	<NULL>	"Clinical diagnosis of fibromyalgia;
Age between 20 and 80 years;
Signing the consent form;"	Don´t have	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-268hqh	Effects of  pulmonary re-expansion maneuver on patients receiving mechanical ventilation	data analysis completed	Intervention	2012-05-01	<NULL>	<NULL>	135	Effects of Manual Chest Compression and Descompression Maneuver on Lung Volumes, Capnography and Pulse Oximetry in Patients Receiving Mechanical Ventilation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-21	Hospital e Maternidade Celso Pierro	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-268hqh	<NULL>	"Age greater than 18 years
Patients on mechanical ventilation
Ramsay sedation scale between 4 and 6 levels
Hemodynamic stability 
No osteoarticular lesions (rib fractures or unstable thorax)."	"Intracranial hypertension &gt; 30 mmHg
Pneumothorax 
Hemodynamic instability with use of high doses of vasoactive drugs, dopamine and dobutamine &gt; 5 µg/kg/min and noradrenalin &gt; 0.5 µg /kg/min"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7mmp6k	Ocular surface evaluation in ocular hypertension or inicial glaucoma patients treated with drops.	data analysis completed	Intervention	2012-04-24	<NULL>	<NULL>	142	Ocular surface evaluation in patients treated with prostaglandin analogues or timolol maleate monotherapy compared to  patients treated with fixed combination of prostaglandin analogues and timolol maleate 0,5% monotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7mmp6k	<NULL>	Glaucoma or ocular hypertension patients with no previous topical hypotensive treatment.	Previous ocular surgery, active ocular inflammation or clinically diagnosed dry eye.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-4b45px	Comparison of methods of oral rehydration therapy in children with acute diarrhea.	data analysis completed	Intervention	2012-04-10	<NULL>	<NULL>	145	Comparison of methods of oral rehydration therapy in children with acute diarrhea.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Centro de Pesquisa Fima Lifshitz	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4b45px	<NULL>	"Male children 2-30 months old
 Pre-classified with acute diarrhea and  dehydration."	"Only breastfeeding nutrition
 With severe malnutrition
 With clinical suspicious or documented signs and symptoms of chronic illness or systemic infection
 Not able to understand the nature of study and sign the inform consent"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6g8yz9	Treating lymphangioleiomyomatosis with doxycycline	data analysis completed	Intervention	2012-03-29	<NULL>	<NULL>	148	Effects of doxycycline on radiological and functional assessment and metalloproteinase blockage in patients with lymphangioleiomyomatosis	<NULL>	2-3, single-arm-study, open	2-3	<NULL>	<NULL>	<NULL>	2011-01-08	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6g8yz9	<NULL>	Patients with an established clinical-radiological or histopathological diagnosis of lymphangioleiomyomatosis	Patients submitted previously to lung transplant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-5d877q	Cardiac responses during rehabilitation in patients undergoing cardiac surgery	data analysis completed	Intervention	2012-04-04	<NULL>	<NULL>	151	Study of cardiac autonomic modulation and pulmonary function in patients undergoing coronary artery bypass grafting and physiotherapy program: phase I of cardiac rehabilitation.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-01	Universidade Federal de São Carlos	Irmandade Santa Casa de Misericórdia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-5d877q	<NULL>	"Coronary artery disease (CAD) 
Elective coronary artery bypass surgery (CABG) carried out with cardiopulmonary bypass (CPB)."	"Patients who had undergone coronary artery bypass surgery (CABG) without cardiopulmonar bypass (CPB) or concomitant surgery;
History of myocardial infarction &lt; 6 months before CABG, severely depressed LVF (left ventricular ejection fraction &lt;30%), acute significant arrhythmias, coexisting chronic obstructive pulmonary disease (COPD), autonomic neuropathy, severe non-cardiac disease; 
Inability or refuse to perform the proposed protocol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-4qzm6s	Physical Exercises, neuropsychiatric disturbances and Activity Daily Living performance on women with Alzheimer´s Disease.	data analysis completed	Intervention	2012-03-04	<NULL>	<NULL>	153	A controlled clinical trial on the effects of physical exercise on neuropsychiatric disorders and instrumental activities in women with Alzheimer’s disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	São Paulo State University	Departamento de Educação Física - Instituto de Biociencias da UNESP/RC	https://ensaiosclinicos.gov.br/rg/RBR-4qzm6s	<NULL>	Women over 60 years with clinical diagnosis of probable Alzheimer&apos;s disease in mild to moderate stages of the disease, residents in the community with independent locomotion.	Elderly males, elderly without cognitive impairment, with other neurological conditions, limited mobility to preclude the exercise protocol and physical prior participation in other exercise programs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-3q3q98	Weight Training, Apathy and Motor Function in Alzheimer&apos;s Disease	data analysis completed	Intervention	2013-02-22	<NULL>	<NULL>	170	Weight Training, Apathy Syndrome and Motor Function in Patients With Alzheimer&apos;s Disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-15	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-3q3q98	<NULL>	Patients diagnosed with Alzheimer´s disease both genders aged 60 years and over. Elderly people with mild and moderate levels of  dementia. Patients and their caregivers that were consistent with the procedures of the  study and who signed the Instrument of Consent. Patients ambulating	Patients with other neuropsychiatric conditions or clinical comorbidities that interfere with the apathetic condition, provided in front or cognitive motor procedures to be developed. Patients who had contraindications to physical activity. Patients with bone-mioarticulares problems, serious heart disease or amputations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-7wm8mz	Response Oxygenation in Premature Newborns with use of Thoracic Elastic Band Positions in Two Body	data analysis completed	Intervention	2013-02-28	<NULL>	<NULL>	171	Effect of Posture Positioning Front Support from Gradil Costal Premature Newborn	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-04-04	Faculdade Medicina Ribeirão Preto - USP	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-7wm8mz	<NULL>	Newborn premature birth with a minimum weight of 1200g and maximum of 2500g the gestational age of 36 weeks maximum, without ventilatory pressure and without supplemental oxygen, without infection and with good general	Newborns classified as extremely premature, history of apnea, heart disease, congenital malformations, severe anoxia, hydrocephalus, post-abdominal surgery, neonatal infection, term newborns, ranked small for gestational age, use of ventilation system positive pressure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-3p7577	Comparison of Anti Pneumococcal Vaccinal Response in HIV-positive Adults	data analysis completed	Intervention	2013-03-13	<NULL>	<NULL>	174	Comparison of Response to Vaccination with Three Different Schemes Pneumococcal Vaccine in Adults Infected by Human Immunodeficiency Virus	<NULL>	1, single-arm-study, double-blind	1	<NULL>	<NULL>	<NULL>	2011-01-01	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-3p7577	<NULL>	All individuals aged 18-60 years with HIV infection documented by enzyme-linked immunosorbent assay (ELISA) and Western-Blot testing, and with T-CD4 count above 200 cells/mm3 in two different occasions in the past six months were eligible. Were included in trial individuals who demonstrated understanding and signed consent form.	Exclusion criteria included: any acute febrile illness at the moment of vaccination, active AIDS-defining clinical condition, previous immunization with any of the pneumococcal vaccines, any systemic malignancy neoplasm, use of immunoglobulin within the last three months, current pregnancy, antecedent of allergy to any of the pneumococcal vaccine components.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-4qpj2r	Effect of Human Ration on Weight Loss and Bone Health in Overweight Women	Data analysis completed	Intervention	2013-04-02	<NULL>	<NULL>	176	Effect of Human Ration in Weight Loss and in Bone Health in Overweight Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-4qpj2r	<NULL>	Female gender. IMC higher than 25 and less than 34.9 kg/m2 and age between 24 and 45 years.	Pregnant or breastfeeding women. Menopausal women or who underwent removal of the uterus. Which used anti-inflammatories. Who presented intolerance or allergy to any ingredient in the product. Which drink´s alcohol or smokes. Who were using the drug for inhibiting appetite. Antidepressants or whatever to interfere in bone mineral metabolism (bisphosphonates, anabolic steroids, calcitonin, fluoride, hormone replacement therapy, androgens, calcium, vitamin D, thiazide diuretics, and statins). Women with a history of conditions or diseases associated with changes in bone mass such as kidney disease (cholelithiasis, chronic renal failure), gastrointestinal disease (celiac disease, chronic liver disease, malabsorption syndrome, gastrectomy or colectomy). History of endocrine disease (hyperparathyroidism, hyperthyroidism or hypothyroidism). Fractures in the last six months. Which had shown restraint for more than two months and showed fluctuations in body weight greater than 5% in the two months before recruitment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-8f57kr	Impact of a Program of Subaquatic Therapeutic Exercises in Elderly Women with Knee Osteoarthritis	Data analysis completed	Intervention	2013-04-15	<NULL>	<NULL>	177	Impact of a Structured Program of Subaquatic Therapeutic Exercises in Elderly Women with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-30	Universidade Federal  de Minas Gerais	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-8f57kr	<NULL>	Elderly aged over 65 years. Diagnosis (clinical and radiological)of knee osteoarthritis. Not undergoing surgery. No history of recent trauma on the knee.  Accessory independent for locomotion. Not subjected to physical therapy in the last three months. With conditions to perform clinical and cognitive activity in the pool. Continents and without contagious dermatological diseases.	Absence of a clinical and radiological diagnosis of knee osteoarthritis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-5hsvfr	The Impact of the Substitution of Convencional Salt for a Salt With Less Sodium on the Blood Pressure of Patients With High Blood Pressure	Data analysis completed	Intervention	2013-04-16	<NULL>	<NULL>	178	The Impact of the Substitution of Convencional Salt for &quot;Light Salt&quot; on the Blood Pressure of Hypertensive Patients	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-14	Linea Sucralose	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5hsvfr	<NULL>	Patients which are regularly monitored by the League of Hypertension of the UFG&apos;s Hospital, residents of the metropolitan area of Goiânia, with stable dose of antihypertensive medication for at least 30 days and with uncontrolled hypertension (BP 140 x 90 at last visit).	Patients with acute or subacute (up to 3 months before the start of the project). Unstable chronic diseases (diabetes mellitus, heart failure, liver disease, chronic renal failure, lung disease or other that, according to the researchers, could compromise the follow-up protocol). Patients, one or more days a week, eat lunch and dinner at places where they can not perform the preparation of meals using only salt supplied by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-58n26h	Effect of Education on Learning and the Diabetes Control in Patients Alloy Hypertension UFG	Data analysis completed	Intervention	2011-06-27	<NULL>	<NULL>	190	Effect of Educational Intervention on the Knowledge and Control of Diabetes in Patients of the Hypertension League of UFG	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2010-04-01	Dalma Alves Pereira	Dalma Alves Pereira	https://ensaiosclinicos.gov.br/rg/RBR-58n26h	<NULL>	Being patient with non-insulin dependent diabetes. Not be participating in another research project. Having physical and economic conditions for the displacement. Agree to participate and signing the consent form.	Being insulin dependent. Having obesity grade III. Miss the scheduled service. Does not agree to participate in research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-6hk9p6	Improve Immunity Through the Physical Exercise to Heart Patients	Data analysis completed	Intervention	2013-05-15	<NULL>	<NULL>	195	Improves the Immune System Through of Exercise for Patients with Chronic Heart Failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Núcleo de Cardiologia e Medicina do Exercício (NCME)	Universidade do Estado de Santa Catarina (UDESC)	https://ensaiosclinicos.gov.br/rg/RBR-6hk9p6	<NULL>	Patients diagnosed with Chronic Heart Failure functional class II and III of Ischemic or hypertensive. Ejection fraction less than 45%. Male. Minimum age 35 years and and maximum of 80 years old. Clinically Stable and being Released by medical assistant to join the program of cardiopulmonary and metabolic rehabilitation through exercise. Not having made or had complications hospitalization in the last month. Sedentary.	To have present as uneventful clinical decompensation with or without hospitalization. Stop taking medicine without doctor consent. Introduced in acute inflammatory diseases. Being patient with primary pulmonary hypertension, pulmonary infections or active pulmonary thromboembolism. Being with clinically decompensated systolic blood pressure above 180mm Hg. Being patient with renal failure, unstable angina, ventricular arrhythmia, have histories of cardiac events (acute coronary syndrome, cardiac surgery, myocardial infarction) within the last four months. Introduced orthopedic or neurological limitations that prevent them from doing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-3mxvc3	Silicium Pastilles Application on Feet in Cases of Lombar Pain	Data analysis completed	Intervention	2013-07-04	<NULL>	<NULL>	204	Stiper Application on Feet Reflexology Points in Cases of Lombar Pain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-05	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3mxvc3	<NULL>	Be aged between 18-65 years and have constant back pain for at least 2 days.	To present pathologies like cancer and malignant lesions on the feet, such as fissures, fistulae, dermatitis, among other which may had caused damage on skin. It was also presented as an exclusion criterion to achieve a number below 10 in Oswestry Disability Questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-2tsr7g	Muscle stretching exercise and emotional stress in pregnants	Data analysis completed	Intervention	2013-07-08	<NULL>	<NULL>	206	Effectiveness of muscle stretching in cortisol levels and in emotional stress of  third trimester pregnant women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Estadual do Centro - Oeste	Prefeitura Municipal de Itapiranga	https://ensaiosclinicos.gov.br/rg/RBR-2tsr7g	<NULL>	Women aged between 18 and 40 years old in the third trimester of pregnancy. They must had medical release for physical activity, prenatal tests up-to-date, junior high school completed and agree to sign the consent for the research.	Rheumatic, neurological, metabolic and/or cardiovascular diseases, smoking and/or alcohol use, body mass index greater than 35, recent treatment with corticosteroids and regular physical activity over the past three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-7ggfkv	Comparison of two ways of using tapings in patients with back pain.	Data analysis completed	Intervention	2012-01-17	<NULL>	<NULL>	208	Comparison of two techniques for using the Kinesio Taping in patients with chronic non-specific low back pain: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Universidade Cidade de São Paulo	Equipe Ricardo Takahashi	https://ensaiosclinicos.gov.br/rg/RBR-7ggfkv	<NULL>	Chronic low back pain in patients that were seeking care; patients with chronic low back pain from the community;  Patients with a pain intensity level of at least 3 points on a 0-10 Pain Numerical Rating Scale.	Patients with any contra-indication for the interventions (i.e. lumbar stenosis, spinal fractures, cancer, acute infections, lumbar osteoporosis, acute rheumatic conditions, any bleeding diseases, spinal tuberculosis, and deep venous trombosis, allergy or intolerance to the material).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-4hn597	Effect of Concurrent Training on Risk Factors and Fatty Liver in Obese Adolescents	Data analysis completed	Intervention	2013-07-15	<NULL>	<NULL>	212	Study of the Effects of non Pharmacological Training on Components of the Metabolic Syndrome and Fatty Liver Disease in Children and Adolescents with Overweight and Obesityobese Adolescents	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4hn597	<NULL>	Classification of obesity according to the pediatric body mass index (BMI) for age and gender, waist circumference (WC) based on the criteria for age, age between 12 and 15 years on the day of assessment, absence of clinical conditions that made physical activities impossible, a free and informed consent for participation in the program signed by the parents or legal guardians.	Participants aged not compatible with the age proposed by the program, the participant has a disease of metabolic, physical or psychological origin that could prevent the emergence of physical exercise and not be classified as obese by BMI.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-8854cd	Diabetic Foot Care	Data analysis completed	Intervention	2013-07-16	<NULL>	<NULL>	214	The Use of Exercises and Instructions for Self-care in Diabetic Patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-12-16	Universidade Federal de Alfenas- UNIFAL-MG	Prefeitura Municipal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8854cd	<NULL>	Volunteers of both sexes, with a clinical diagnosis of type 2 diabetes for more than 5 years, with a minimum age of 30 years and maximum 85 years in routine medical monitoring in a Basic Health Unit in the city of Alfenas	Volunteers with some neurological disorders that produce balance disorders, with a history of alcoholism, herniated disc, leprosy, injuries and amputations of lower limbs, subject to inability to participate in all testing and training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-5533p2	Impact of a Physical Activity Program on Plasma Concentrations of Adipocitokines in Overweight and Obese Schoolchildren from Public Schools at Ouro Preto and Barbacena Cities, Minas Gerais State	Data analysis completed	Intervention	2013-07-16	<NULL>	<NULL>	215	Impact of a Physical Activity Program on Plasma Concentrations of Adipocitokines in Overweight and Obese Schoolchildren from Public Schools at Ouro Preto and Barbacena Cities, Minas Gerais State	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Federal de Minas Gerais	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5533p2	<NULL>	"Children between six and nine years enrolled in public schools in the urban area of the city of Ouro Preto.
Children whose parents consented to their participation by signing the Consent.
Children between six and nine years considered overweight and obesity."	Children aged six to nine years, with chronic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-6pvzyt	Aplicattion of Hipromelosis (Ophthalmic Gel) in Lacrimal Punctum Closure in Dry Eye Patients	Data analysis completed	Intervention	2013-07-31	<NULL>	<NULL>	218	Occlusion of Inferior Lacrimal Punctun with Hypromelosis in Dry Eye Patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital Universitário de Brasília - Universidade de Brasília	Hospital Universitário de Brasília - Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6pvzyt	<NULL>	"Age over 18 years; Age under 70 years;
Ambulatorial patients of HUB-Hospital Universitário de Brasília ; Dry eye patients; Patients complaining about current treatment; no other ocular diseases previously or during the study."	Develop systemic or ocular disease during the study; Initiate use of new systemic or ophthalmologic medications in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-65n292	Prevention Program of Diabetes in São Paulo	Data analysis completed	Intervention	2013-08-06	<NULL>	<NULL>	220	Analysis of the Cardiometabolic Risk Profile of a Population Sample from São Paulo City  and Implementation of a Prevention Program for the Prevention fo Type 2 Dabetes Mellitus	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Faculdade de Saúde Pública, USP	Faculdade de Saúde Pública, USP	https://ensaiosclinicos.gov.br/rg/RBR-65n292	<NULL>	Individuals with prediabetes (impaired fasting glycemia: fasting glycemia between 100 and 125 mg/dL; impaired glucose tolerance: 2-hour glucose between 140 and 200 mg/dL) or fulfilling metabolic syndrome criteria according to the International Diabetes Federation for Latin-American populations.	Medical history of neurological or psychiatric disturbances, thyroid, liver, renal and infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-6xhgzb	What is the effect of iontophoresis in the treatment of patients with primary palmar hyperhidrosis?	Data analysis completed	Intervention	2013-08-07	<NULL>	<NULL>	223	Treatment of Palmar Hyperhidrosis with Iontophoresis: Case Reports	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-10	Universidade Católica do Salvador	Universidade Católica do Salvador	https://ensaiosclinicos.gov.br/rg/RBR-6xhgzb	<NULL>	Individuals of both sexes who had bilateral primary palmar hyperhidrosis	Individuals presenting metallic implants in the upper limbs, impaired sensation in the hands of, who used drugs that caused the malfunction, or perform some other type of treatment for hyperhidrosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-8nxn75	Effects of Cervical Manipulation on Upper Limb Motor Control in Subjects with Neck Pain	Data analysis completed	Intervention	2013-08-26	<NULL>	<NULL>	236	The Effect of Motor Control Deficits and Physical Therapy Interventions on the Grip Force Control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-10	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8nxn75	<NULL>	History of three or more neck pain episodes in the past three months.	Previous history of rheumatic disease, cervical myelopathy, tumors, central or peripheral neurological disorders. History of major trauma, fracture or surgery in the neck, shoulder and/or upper limb. Signs of nerve root compression as important muscle weakness affecting the upper limbs, reduction or loss of biceps and triceps reflexes, decreased sensation in the dermatomes of the upper limb. Red flags contraindicating cervical manipulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-75scwh	Comparison of Two Types of Training in Physical and Organic Performance	Data analysis completed	Intervention	2013-07-08	<NULL>	<NULL>	239	Effects of Concentric vs Eccentric Resistance Training in Clinical, Functional, Cardiovascular and Biological Parameters	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-09-20	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-75scwh	<NULL>	Adults with age between 18 and 30 years old, be male, self declared healthy and no medical restriction for physical activity, classified as physically active by IPAQ (International Physical Activity Questionnaire)	Subjects with cardiovascular, respiratory and/or metabolic disorders, alcoholic, smokers, injury episode osteoarticular or muscle-tendon in the lower limbs and/or column in the last year and did participate in weight-training program for at least 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5qrt8h	Effectiveness of denture adhesives in chewing of complete denture wearers	Data analysis completed	Intervention	2012-05-08	<NULL>	<NULL>	243	Effectiveness of denture adhesives on the kinesiographic records and satisfaction of complete denture wearers	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-10	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-5qrt8h	<NULL>	"Adults;
Mentally agile and responsive;
Resilience and alveolar volume normal; Absence of dysfunctions in the stomatognathic system;
Absence of debilitating systemic changes."	"Debilitating neurological or systemic diseases;
Cardiac pacemaker;
Need for pre-prosthetic surgery."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-3ksb6x	Manual therapy and exercises applied to cervical spine in patients with temporomandibular disorders	Data analysis completed	Intervention	2013-09-22	<NULL>	<NULL>	254	Effect of a cervical rehabilitation protocol in clinical condition and mandibular function in patients with temporomandibular disorders	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-10	Universidade Federal São Carlos - UFSCar	Universidade Federal São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-3ksb6x	<NULL>	Patients diagnosed with myogenic or mixed temporomandibular disorders	Patients diagnosed with arthrogenic or discogenic temporomandibular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5668v4	Effect of Diet and Omega-3 Supplementation on Markers of Risk for Heart Disease in  Postmenopausal Women	Data analysis completed	Intervention	2013-10-04	<NULL>	<NULL>	255	Impact of Dietary Adequacy and Omega 3 Supplementation on the Metabolic and Inflammatory Markers of Cardiovascular Risk in Postmenopausal Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista  UNESP, Julio de Mesquita Filho	FAPESP - Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5668v4	<NULL>	Women with: (1) date of last menstrual period for at least 12 months, (2) age between 45 and 65 years, (3) at least three criteria for the diagnosis of metabolic syndrome (waist circumference &gt; 88 cm; triglycerides &gt; 150 mg/dL; HDL cholesterol &lt; 50 mg/dL; blood pressure &gt; 130/85 mmHg or under therapy; fasting glucose &gt; 100 mg/dL or under therapy).	The exclusion criteria were: (1) presence of cardiovascular disease manifests current or previous, (2) use drugs that affect lipoprotein metabolism (hormone therapy, statins), (3) alcoholic or drogaditas; (4) story autoimmune diseases, (5) history of malignancy; (6) intolerance or food allergy to fish; (7) insulin-dependent diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-4xdkq4	Changes in muscle strength in elderly women after Kabat based training	Data analysis completed	Intervention	2013-10-08	<NULL>	<NULL>	256	Analysis of change in muscle conditioning before and after Kabat Proprioceptive Neuromuscular Facilitation based training in a elderly population	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4xdkq4	<NULL>	Women, physically active, aged between 60 and 70 years, healthy, no history of surgery or chronic pathologies such as systemic arterial hypertension and diabetes.	Suffering from chronic diseases of any kind; history of surgery; sedentary, they do not agree with the terms of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-3vjfr8	Prognostic indexes of reintubation	Data analysis completed	Observational	2013-10-16	<NULL>	<NULL>	258	Validation of combination of prognostic indexes for reintubation in adults and verification of its applicability in different clinical situations	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-3vjfr8	<NULL>	"patients under mechanical ventilation
adults
intensive care unit 
considered able to be extubated"	"traqueotomized
without weaning criteria"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-23kwzb	Effects of Therapeutic Currents in Health Subjects	Data analysis completed	Intervention	2013-10-30	<NULL>	<NULL>	263	Comparison of Sensorial Discomfort and Peak Torque During Neuromuscular Electric Stimulation With Medium and Low Frequency Currents	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-18	Univerdade Federal de São Carlos	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-23kwzb	<NULL>	Being female, healthy, physically active, aged between 18 and 30 years, body mass index (BMI) between 20 and 25 kg / m², with range of motion and knee function preserved, free from orthopedic diseases, pulmonary, cardiovascular, immune, and metabolic or chronic.	Age above 30 years. Male.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-9gfmm5	Evaluation of the effect of two gingival treatments in the development of gingival disease in children with heart disease	Data analysis completed	Intervention	2013-10-30	<NULL>	<NULL>	265	Evaluation of the effect of two periodontal treatments in the development of periodontal periodontal disease in children with heart disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-29	Universidade Estadual do Oeste do Paraná - Unioeste	Universidade Estadual do Oeste do Paraná - Unioeste	https://ensaiosclinicos.gov.br/rg/RBR-9gfmm5	<NULL>	The children should have between 8-12 years of age with chronic periodontitis, with at least 2 sites with probing depth greater than 5 mm and clinical attachment level over 2 mm, bleeding on probing and gingival inflammation to clinical examination. The teeth should perform reasonably aligned, with a minimum of 20 teeth in the arch, with the clinical examination in the buccal, lingual / palatal, mesial and distal	Use of antibiotics and anti-inflammatories, steroids or no steroids in the month prior to the study; periodontal treatment in the previous 6 months, and those with any chronic inflammatory disease such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or Chron&apos;s disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-6rzhnh	Defense mechanisms evaluation in abstinent smokers	Data analysis completed	Intervention	2013-12-18	<NULL>	<NULL>	269	Participation of Th1/Th2 cytokines and mucociliary clearance in current and abstinent smokers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-08	Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista Júlio de Mesquita Filho	Departamento de Fisioterapia da Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6rzhnh	<NULL>	Smokers with at least 20 years of smoking; both sexes; apparently healthy; enrolled in the Smoking Cessation Programme from Faculty of Sciences and Technology of São Paulo State University	Diagnosis cystic fibrosis, bronchiectasis, immotile cilia syndrome, chronic obstructive pulmonary disease, smoking-related diseases, history of nasal surgery or trauma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-9mndx8	Effect of the Pilates in elderly	Data analysis completed	Intervention	2014-02-03	<NULL>	<NULL>	273	Effect of the method pilates in flexibility, quality of life and level of pain in the elderly.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-08	Faculdade de Filosofia e Ciências- UNESP	Centro de Estudos da Educação e da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-9mndx8	<NULL>	Women over 60, who reported the presence of chronic musculoskeletal pain, continuous or essentially continuous with exacerbations for at least six months prior to the study.	Neurological symptoms, discrepancy between the lower limbs greater than two centimeters, ankylosing spondylitis, rheumatoid arthritis, herniated disk, tumor, infection, vertebral fracture, cauda equina syndrome, cognitive impairment and cardiovascular or dropouts during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-6fmfr8	Ultrasound-guided ophthalmic anesthesia	Data analysis completed	Intervention	2014-02-26	<NULL>	<NULL>	278	Ultrasound-guided periconal blockade: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-04	Faculdade de Medicina de Botucatu (FMB), UNESP	Instituto Benjamin Constant	https://ensaiosclinicos.gov.br/rg/RBR-6fmfr8	<NULL>	Cataract patients, both genders, aged between 18 and 95 years old, healthy or with mild or moderate systemic disease without functional limitation according to the American Society of Anesthesiologists I-II, respectively.	Patients with high myopia (axial length&gt; 26mm) and the presence of staphyloma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-23nf3s	Effect of group vaginal muscle training in  post-menopausal women	Data analysis completed	Intervention	2014-05-07	<NULL>	<NULL>	291	Effect of a group pelvic floor muscle training in climateric and post-menopausal  women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-14	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-23nf3s	<NULL>	Post-menopausal women  for at least 5 years; with complaints from urogynecological symptoms; participants of Physical Activity in Congonhal&apos;s City.	women with vaginal or urinary infections; pelvic cancer; uncontrolled metabolic disorders (hypertension and diabetes); cognitive, psychiatric or neurological disorder; chronic vaginal pain; inability to contract the pelvic floor muscles (PFM); pelvic organ prolapse stage IV according to the Pelvic Organ Prolapse Quantification System (POP-Q) and severe heart disease , who added up to four volunteers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-5tdnbr	Effects of a health education program for patients with fibromyalgia	Data analysis completed	Intervention	2014-05-29	<NULL>	<NULL>	299	The impact of a health education program on neuroimmune and behavioral aspects of fibromyalgia patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-11-01	Universidade Federal de Minas Gerais - UFMG	Centro Universitário de Formiga - MG (UNIFOR-MG)	https://ensaiosclinicos.gov.br/rg/RBR-5tdnbr	<NULL>	Female gender; aged between 18 and 60 years; fibromyalgia diagnosis confirmed by a medical specialist	Less than 18 years, over 60 years old; modification in the pharmacologic treatment in the last three months; chronic inflammatory condition associated; autoimmune disease associated; history or presence of psychiatric disorders, infectious diseases, use of anti-inflammatory, antiallergic or antibiotic drugs in the last three months, pregnant women, lactating, participation in lower 80% of the classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-7fyc7g	Evaluation of Maternal Training and Auxiliary Methods for Improving Toothbrushing on Babies	Data analysis completed	Intervention	2014-05-29	<NULL>	<NULL>	300	Evaluation of Mothers Training and Auxiliary Methods on Babies Toothbrushing Effectiveness	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-10	Centro Universitário de Maringá	Bitufo Montagem e Comércio de Escovas Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7fyc7g	<NULL>	Babies presenting at least four deciduous teeth in the mouth, with at least half of the crown exposed; Babies free from tooth decay	Infants presenting carious lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-38nkj6	Effect of strength training in older depressed	Data analysis completed	Intervention	2014-06-10	<NULL>	<NULL>	302	Effect of strength training in older depressed	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Instituto de Neurologia Deolindo Couto	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-38nkj6	<NULL>	Right-handed; sedentary for more than three months; performing more than one month pharmacological treatment; clinical diagnosis using the criteria of the Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV).	Score over 18 points on the Hamilton Depression Scale; Score under 24 points in the Mini - Mental State Examination; Psychiatric comorbidities; neurodegenerative disease; severe cardiovascular disease; illiteracy; poor mobility; balance disorders; visual and / or auditory sharp.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-2nwk89	Restoration of teeth with different ways of insertion and protection of restorative material	Data analysis completed	Intervention	2014-07-09	<NULL>	<NULL>	312	Longevity of ART restorations in proximal cavities using different techniques of insertion and superficial protection	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-20	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2nwk89	<NULL>	Healthy volunteers; both genders; between 6 and 7 years of age; clinically presenting proximal caries lesion; lesion accessible to manual instruments used in atraumatic restorative treatment	Non-cooperative patients; restorations on the selected tooth; presence of fistula or abscess near the tooth selected to the research; presence of pulp exposure or mobility in the selected tooth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-4qsf57	Study of cardiac and metabolic control in women with polycystic ovary syndrome	Data analysis completed	Intervention	2014-07-14	<NULL>	<NULL>	315	Correlation study of the adaptations into cardiac autonomic modulation and metabolic parameters in women with polycystic ovary syndrome submitted to aerobic training	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-05	Fundação de Amparo à Pesquisa do Estado de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qsf57	<NULL>	Women aged between 18 and 40 healthy years and diagnosed with polycystic ovarian syndrome belonging to the outpatient clinic of Gynecology and Obstetrics of the University were not engaged in regular physical activity (least 2 times per week)	Exclusion criteria: women in use of contraceptives or other drug treatment, smoker (regular consumption of cigarettes or tobacco-derived.); alcoholic (physical and psychological dependence on alcohol); who had mental disorders that hindered the understanding and execution of tests; disabling musculoskeletal disorders (osteoporosis, fractures unconsolidated, muscular dystrophy, low back pain) and cardiovascular disease (myocardial infarction, heart failure, arrhythmias).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-38p23s	Psychological treatment for obese adolescents and their effects on social interaction and body mass index	Data analysis completed	Intervention	2014-07-18	<NULL>	<NULL>	317	"Multifocal intervention in obese adolescents: social competence, 
behavior problems, academic performance and weight reduction"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-18	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-38p23s	<NULL>	Both mass index above than the 95th percentile for age featuring obese according to the curves of the Center for Disease Control and Prevention (CDC, 2000); between 10 and 19 years old; willingness to participate in all program activities.	Psychological disorders; use of medications that could interfere in the variables; physical difficulties that impeded the development of all activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-22y7p9	Effect Of Muscle Strengthening on The Upper Limb Motor Recovery After Stroke	Data analysis completed	Intervention	2013-03-07	<NULL>	<NULL>	318	Effects of Functional and Analytical Strength Training on Upper-Extremity Motor and Functional Recovery After Stroke: a Randomized, Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Hospital Mãe de Deus	https://ensaiosclinicos.gov.br/rg/RBR-22y7p9	<NULL>	six months to five years since the onset of a unilateral stroke; ability to comprehend simple instructions (Mini-Mental State Examination with a minimum score of 20); no pain, contractures, or severe weakness in shoulder flexion muscles (&lt; 3 in the Manual Muscular Testing); and no upper-limb rehabilitation during this research.	other neurological, neuromuscular, or orthopedic disease; severe comorbidity diseases; or severe increase of upper extremity muscular tone(&gt; 3 points according to the modified Ashworth scale).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8dmcnj	Evaluation of the effects of the meditation practices on attention and mood of adults with attention deficit hyperactivity disorder	Data analysis completed	Intervention	2014-07-29	<NULL>	<NULL>	319	Evaluation of the effects of the mindulness meditation practices on cognition of adults with attention deficit hyperactivity disorder	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade Federal de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-8dmcnj	<NULL>	Individuals of both sexes, aged between 18 and 40 years, which have Portuguese as their first language, with high school education, normal vision or corrected to normal and normal hearing. The patients with ADHD are diagnosed by their doctors, they should be taking stable doses of methylphenidate (for at least a month) for their disorder as prescribed by their doctors.	The volunteers with neurological and psychiatric disorders such as psychosis, obsessive-compulsive disorder or Tourette&apos;s syndrome, and volunteers with prior experience with meditation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-55y665	Treatment program for changes in posture	Data analysis completed	Intervention	2014-08-04	<NULL>	<NULL>	322	Rehabilitation program of postural deviations	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-09-24	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-55y665	<NULL>	Able participants performing physical activity, of both genders aged 11 to 28 years, medical referral and the presence of greater than 10, confirmed by measurement of the Cobb angle on colonography scoliosis, featuring structural curves or changes in kyphosis and lordosis and Statement of Consent signed by parents or guardians.	Use of prostheses and / or orthoses, surgeries of the spine, presence of scoliosis etiology of idiopathic not, pregnancy, difference in leg length greater than 1,5 cm thus determining a cause of scoliosis is not idiopathic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8wt2fy	Comparison of Two Types of General Anesthesia, Venous versus Inhalatory, regarding the Risk of Renal Injury after Videolaparoscopic Obesity Surgery	Data analysis completed	Intervention	2014-08-13	<NULL>	<NULL>	325	Efficacy of Total Intravenous Anesthesia (TIVA) in blocking Perioperative Elevation of NGAL in Laparoscopic Bariatric Surgery	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2010-10-01	Adriano Teixeira Fernandes	Norma Sueli Pinheiro Módolo	https://ensaiosclinicos.gov.br/rg/RBR-8wt2fy	<NULL>	morbidly obese patients, scheduled for video laparoscopic bariatric surgery; both gender; age between 18 and 65 year.	volunteers with lung disease; heart failure; renal failure; cancer of any etiology; patients on chronic corticosteroid use; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-4pc22n	Acute effects of smoker&apos;s lung defense mechanism	Data analysis completed	Intervention	2014-08-18	<NULL>	<NULL>	327	Acute response of smoker&apos;s mucociliary clearance exposed to moderate aerobic exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-21	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; - Faculdade de Ciências e Tecnologia	"Departamento de Fisioterapia da Universidade Estadual Paulista ""Júlio de Mesquita Filho"" - Faculdade de Ciências e Tecnologia"	https://ensaiosclinicos.gov.br/rg/RBR-4pc22n	<NULL>	Subjects between 30 and 50 years old, both genders, with normal lung function attested by spirometry and absence of illnesses that interfere with exercise performance or autonomic modulation (eg, cerebrovascular, cardiac, orthopedic, rheumatic or metabolic disease, diabetes, alcoholism).	Not comprehension or non-cooperation on the procedures and methods of research; non-attendance at one of the days of the experimental protocol; subjects with lung disease diagnosed, history of surgery or nasal trauma, nasal septal deviation or inflammation of the upper airways observed in clinical evaluation during the interview and experimental protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-86vp8x	Effects of Pilates in patients with cystic fibrosis	Data analysis completed	Intervention	2014-08-22	<NULL>	<NULL>	329	Analysis of the effects of pilates method associated with respiratory physiotherapy in patients with cystic fibrosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-86vp8x	<NULL>	Patients between 7 and 20 months of age, both genders, diagnosed with Cystic Fibrosis; presenting forced expiratory volume in one minute (FEV1) above 30% of predicted; with availability to attend the sessions of care.	Patients enrolled in a program of physical activity; presenting Cor Pulmonale severe; presenting twenty-five percent or more absences in the attendance sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-37jpt3	Comparison of the effect the lysine clonixinate (Dolamin ®) and ibuprofen (Advil ®) in reducing pain in patients with tendinopathy	Data analysis completed	Intervention	2014-09-16	<NULL>	<NULL>	335	A Randomized single-blinded, parallel group and unicentric Phase IV Clinical Study of non-inferiority, comparing the drug Lysine Clonixinate (Dolamin®) and Ibuprofen (Advil®) in reducing acute pain related to tendinopathy in patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2012-05-23	CREB-Centro de Reumatologia e Ortopedia Botafogo Sociedade Simples LTDA	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-37jpt3	<NULL>	"Volunteers be carrying from acute pain related to tendinopathy (tendinitis, tenosynovitis and bursitis of the shoulders, wrists / hands, knees and ankles / feet and require immobilization;
age between 18 and 65 (sixty five) years; Indicate, in max, grade 7 in the Visual Analogue Scale (VAS) of pain; Having signed and dated the &apos;Informed of Consent Form&apos; (ICF) specified for this study, prior to any participation in procedures related to it."	"None of the patients included in this study should be carrying from acute pain related to tendinopathy at the hip; having a history of asthma or bronchospasm, nasal polyps, allergic reactions and / or induced by acetylsalicylic acid (aspirin) or other anti-inflammatory drugs; history of gastrointestinal bleeding due to the use of NSAIDs; is receiving treatment with other anti-inflammatory drugs, corticosteroids or analgesics; Is receiving treatment with oral anticoagulants, ticlopidine, heparin and thrombolytics; be pregnant and / or lactating; be hypersensitive (allergic) to any of the components of the formula;
8. Be a regular user of alcohol and barbiturates; have hepatic or renal impairment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-8wx7qb	Evaluation of phone calls in promoting self-care in Diabetes	Data analysis completed	Intervention	2014-09-22	<NULL>	<NULL>	337	Evaluation of monitoring telephone in promoting self-care in Diabetes in primary health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-06	Universidade Federal de Minas Gerais	Heloisa de Carvalho Torres	https://ensaiosclinicos.gov.br/rg/RBR-8wx7qb	<NULL>	Members diagnosed with Type 2 Diabetes Mellitus; have between 30 and 80 years; own mobile phone or fixed line.	Members diagnosed with Type I Diabetes; not answer calls for more than five consecutive attempts made; users with psychiatric disorders or complications of the disease which adversely affects the ability to answer the questionnaire of self-care; users who have moved.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-2h5b53	Carbohydrate supplementation in athletes	Data analysis completed	Intervention	2014-10-02	<NULL>	<NULL>	339	Effects of carbohydrate supplementation on physical performance, and hormonal,  immunological and psychological responses during and after an intensive training program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-08	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2h5b53	<NULL>	Male athletes, aged between 20 and 40 years old, running above 50 km / week, and minimum of 4 years of intense physical training.	Presence of orthopedic, or cardiovascular or hormonal / metabolic diseases, or anemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-25b7xh	Effect of the pH, consistency and quantity of fluoride of the toothpaste in the fluoride retention on enamel surface	Data analysis completed	Intervention	2014-10-21	<NULL>	<NULL>	343	Effect of the pH, consistency and fluoride concentration of liquid dentifrices in caries control of fluoridated and not fluoridated áreas: randomized clinical trials	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-08-02	Faculdade de Odontologia de Bauru	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-25b7xh	<NULL>	Healthy volunteers, aged between 20 and 35 years old, not using orthodontic appliances and that have not been involved in other studies 3 months before the present research.	Volunteers using orthodontic appliances; volunteers using other fluoridated products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-42c6gz	Characterization of trigger points in the rectus abdominis muscle in women with chronic pelvic pain using electromyography.	Data analysis completed	Observational	2014-11-05	<NULL>	<NULL>	345	Characterization of local mechanisms (trigger points) of abdominal myofascial syndrome in women with chronic pelvic pain using surface and needle electromyography.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-09-19	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto	Departamento de Ginecologia e Obstetrícia - Comissão de Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-42c6gz	<NULL>	Women with chronic pelvic pain; age over 18 years; presence of all clinical diagnostic criteria for abdominal myofascial pain syndrome.	Women with typical clinical symptoms of endometriosis or painful bladder syndrome or irritable bowel syndrome or other disease that justify or contribute to chronic pelvic pain; endometrioma or hernia evidenced by ultrasound of abdominal wall; obesity (BMI &gt; 30 kg/m²); use of anticoagulant; coagulation disturbance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-5tzcnw	Influence of the depression treatment with escitalopram in mild to moderate arterial hypertension	Data analysis completed	Intervention	2014-11-05	<NULL>	<NULL>	346	Influence of the depression treatment with escitalopram in mild to moderate arterial hypertension	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-03-01	Marcello Finardi Peixoto	Marcello Finardi Peixoto	https://ensaiosclinicos.gov.br/rg/RBR-5tzcnw	<NULL>	18 to 65 years; arterial hypertension stage 1 or 2; major depressive disorder	Liver insuficiency; cardiac insuficiency, renal insuficiency; secundary arterial hypertension; use of psycotropics; psychotic disorder; alcohol or substances disorder; suicide risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-4m5yhw	The effect of video games and conventional physiotherapy in the physical fitness of elderly	Data analysis completed	Intervention	2014-12-02	<NULL>	<NULL>	355	Analysis of the intervention on physical fitness of elderly San Pedro neighborhood , Teresina, Piaui : a comparative study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-01	Faculdade Santo Agostinho	Faculdade Santo Agostinho	https://ensaiosclinicos.gov.br/rg/RBR-4m5yhw	<NULL>	Of age or over 60 years , a medical certificate with authorization for physical activity , participating constantly in the center of coexistence and accept volunteer study .	Motor or cognitive disabilities that prevented the activity .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-746nfd	Ventilation by nasal apparatus in preterm infants	Data analysis completed	Intervention	2015-01-15	<NULL>	<NULL>	371	Application of noninvasive positive pressure ventilation after extubation in neonates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-12	Universidade Federal de Minas Gerais	Hospital Sofia Feldman	https://ensaiosclinicos.gov.br/rg/RBR-746nfd	<NULL>	Preterm newborns admitted to the Neonatal Intensive Care Unit of the Hospital Sofia Feldman, diagnosed with Respiratory Distress Syndrome of the Newborn (characterized by progressive respiratory failure after birth), gestational age less than or equal to 34 weeks and weights of the 500 grams less than or equal to 1500 grams classified as appropriate for gestational age, requiring ventilatory support after extubation	Newborns with congenital anomalies that compromise the cardiorespiratory system, genetic disorders, neuromuscular disease, malformations of the central nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-7w7ddy	Impact of psychotherapy in choosing sexual partners of patients with sexual deviance receiving drug treatment	Data analysis completed	Intervention	2015-01-21	<NULL>	<NULL>	373	Impact of psychotherapy in choosing sexual partners of patients with paraphilias receiving drug treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-18	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Carmita Helena Najjar Abdo	https://ensaiosclinicos.gov.br/rg/RBR-7w7ddy	<NULL>	Male, any ethnicity, age 18 years or more, literate; pedophiles who have sexual fantasies involving minors (no sexual activity or use of child pornography current or previous); sign the document authorizing the participation	Suicide risk, psychosis not stabilized; use of physical violence; previous or current history of children sexual abuse, possession, production, custody, disclosure or access to pornographic material involving childrens; patients planning child sexual abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-6jd8nq	Effect of the Pilates in elderly	Data analysis completed	Intervention	2015-02-03	<NULL>	<NULL>	380	Effect of the method Pilates in relation:  thoracic hyperkyphosis and balance postural in elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-08	Faculdade de Filosofia e Ciências (FFC)- Universidade Estadual Paulista &apos;Júlio de Mesquita Filho&apos; (UNESP)	Centro de Estudos da Educação e da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-6jd8nq	<NULL>	Volunteers of the feminine gender,  aged between 60 and 75 years, angle larger than 40º in the curvature of the thoracic spine in the sagittal plane.	They don&apos;t present neurological sequelae, motor and comprehension deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-2tjrgb	Evaluation of the implementation of school prevention programs to drug use for children and adolescents	Data analysis completed	Intervention	2015-02-06	<NULL>	<NULL>	384	Evaluation of the implementation of school prevention programs to drug use for children and adolescents	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Federal de São Paulo - UNIFESP	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-2tjrgb	<NULL>	Schools listed by the Secretary of Education of the state of São Paulo and Santa Catarina; schools that did not have any prominence in relation to drug use by students or explicit traffic around; schools without formal programs to prevent drug use in progress	Student who not consented to fill the pre and post test questionnaires about their drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-82y4dz	Evaluation of the skin firmness and elasticity	Data analysis completed	Intervention	2015-02-18	<NULL>	<NULL>	393	Evaluation of the skin firmness and elasticity	<NULL>	4, single-arm-study, single-blind	4	<NULL>	<NULL>	<NULL>	2014-05-15	KOSMOSCIENCE CIENCIA E TECNOLOGIA COSM IMP EXP LTDA	Herbarium Laboratório Botânico Ltda	https://ensaiosclinicos.gov.br/rg/RBR-82y4dz	<NULL>	Female volunteers, aged between 18 and 60 years, with skin phototype I to IV and intact skin in the region of the test; signs of sagging in the area evaluated; good physical condition and mental health; agreement not to use any topical products on the arms between the 48 h period before the day of the beginning of the study until the end of this; signing the Informed Consent Form ICF.	"Skin marks in the experimental area that interfere with evaluation of possible skin reactions, pigmentation disorders , vascular malformations , scars , increased hairiness , freckles and warts aplenty, sunburn ; dermatoses active local or widespread , that may interfere with results of the study .
Pregnant or lactating ; a history of allergic reactions , irritation or discomfort to intense feelings of topical products : cosmetics or medicines ; history of atopy ; intense sun exposure or tanning session up to 15 days before the initial evaluation or during the study prediction of intense sun exposure during the study ; body dermatological aesthetic treatment or up to 03 weeks before selection, such as : mesotherapy , carboxiterapia and body peels.
Use of the following medications topical or systemic use : immunosuppressants , antihistamines , NSAIDs and corticosteroids to 2 weeks prior to or during the study period ; treatment with Vitamin A acid and / or its derivatives orally or topically for 1 month prior to study initiation .
Be participating in another study or have participated in another study with cosmetic until a week before the study inclusion ; ingestion of nutritional supplements that can influence the results of the study ; any condition which , in the opinion of the investigator , may compromise the evaluation of the study ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-7d9dth	Comparison between ventilation with a pressure and with two positive pressure in the nostrils of premature newborns	Data analysis completed	Observational	2015-02-19	<NULL>	<NULL>	394	Comparison of nasal CPAP and nasal CPAP with a Cycling Time in preterm infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-11-17	Universidade de Franca	Santa Casa de Misericórdia de Franca	https://ensaiosclinicos.gov.br/rg/RBR-7d9dth	<NULL>	Infants born at a gestational age of less than 37 weeks and weighing less than 2,500g, who received noninvasive ventilation.	Newborns with congenital malformations, abdominal post-surgery and neonatal infection as well as term newborns	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-8xj48n	Urinary incontinence, sexual function and pelvic floor muscle strength during pregnancy and postpartum period	Data analysis completed	Intervention	2015-02-19	<NULL>	<NULL>	395	Perineal care during pregnancy and postpartum period: prevention and morbidity related to pelvic floor muscle strength, sexual function and urinary continence	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-21	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xj48n	<NULL>	Having urinary incontinence during the current pregnancy, until the 24th week; Not having undergone surgery urogenital prior; Not having diseases that can interfere with pelvic floor muscle strength (prolapse of pelvic organ, neurological diseases, diabetes, pelvic injury or spinal); Be 18 years old or more; Having completed elementary school; Having difficulty in understanding Portuguese language or in communication.	Having multiple pregnancy; Having obstetric complications during pregnancy (haemorrhagic syndromes, isthmus-cervical insufficiency, premature labour, recurrent urinary tract infection); Offer resistance against the insertion of the perineometer in the vagina; Not adherence to complete physiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-6rtcvb	Effect of neural mobilization and self-mobilization in the flexibility of the hamstrings in elderly women	Data analysis completed	Intervention	2015-02-20	<NULL>	<NULL>	397	Effect of neural mobilization and automobilization in hamstring flexibility in older	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Associação Teresinense de Ensino SC LTDA	Centro de Convivência da Terceira Idade	https://ensaiosclinicos.gov.br/rg/RBR-6rtcvb	<NULL>	The elderly From 60 years; attendance NAS activities developed in the Social Center of the Third Age ; Consent to Participate in Study.	Presence of severe joint deformities or traumatic orthopedic origin; acute inflammatory diseases ; Deep vein thrombosis ; neurological signs, lack of cooperation in the procedures that were performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-7btt63	Evaluation of empowerment in education group for Diabetes	Data analysis completed	Intervention	2015-03-04	<NULL>	<NULL>	411	Evaluation of the process of empowerment group education in Diabetes in Primary Health Care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-01	Escola de Enfermagem da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7btt63	<NULL>	Patients of Health Basic Units diagnosed with type 2 diabetes confirmed by medical records, who participated in at least three education group meetings, as a minimum age of 30 and maximum of 80 years, of both sexes and who signed the Terms of Consent.	Patients from Basic Health Units with Type I Diabetes diagnosis; not attend at least three group education meetings; users with psychiatric disorders or complications of the disease that affect the ability to respond to self-care tools and empowerment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-472p29	Comparison of physical exercise in elderly	Data analysis completed	Intervention	2015-03-09	<NULL>	<NULL>	417	Comparison of physical exercise in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Universidade Norte do Paraná - UNOPAR	Universidade Norte do Paraná - UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-472p29	<NULL>	Women&apos;S; between 60 and 70 years; medical statement for physical exercise; sedentary for at least 6 months	Cognitive impairment according to the Mini Mental State Examination; functional limitations in walking; the use of support devices; affirmative response regarding comorbidities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-686gts	The effect of psychoeducation in reducing the burden of caregivers from mental disorders	Data analysis completed	Intervention	2015-03-19	<NULL>	<NULL>	425	Effectiveness of support in psychoeducation in reducing the burden for families of patients with psychological distress	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Católica de Pelotas	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-686gts	<NULL>	Caregivers of patients attending in mental health services in the city of Pelotas with emotional overload. Caregivers whith more than 18 years old. Caregivers who living in the urban area of the city. Caregivers of both genders	Caregivers of patients attending in mental health services in the city of Pelotas with severe psychological disorders. Caregivers who have difficulty in understanding. Caregivers  under 18 years old. Caregivers who can not participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-35xrwf	Change in the chest and blood pressure after exercise the muscle of respiration of patients with lung problem	Data analysis completed	Intervention	2015-04-06	<NULL>	<NULL>	435	Biomechanical and hemodynamic changes in patients with COPD treated with transcutaneous electrical stimulation diaphragmatic	<NULL>	0, single-arm-study, open	0	<NULL>	<NULL>	<NULL>	2010-07-31	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-35xrwf	<NULL>	Drug stability;smoking cessation; Classification COPD grade III  and IV; maintenance lifestyle; men and women; aged 18 to 80 years.	Metallic prosthesis; pacemaker; dermal injury.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-82gqqk	Platelet Rich Plasma infiltration for Hip Bursitis	Data analysis completed	Intervention	2015-04-07	<NULL>	<NULL>	438	Comparison of Platelet Rich Plasma (PRP) infiltration with Corticosteroid + Local anesthetic in patients with Hip tendinobursitis	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2011-07-31	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-82gqqk	<NULL>	Twenty hips; both genders; aged eighteen to seventy nine years; more than three months of lateral hip pain; pain over the greater trochanter; painful with forced hip abduction; pain at rest; magnetic resonance imaging with diagnosis of tendinobursitis.	Previous hip infiltrations; intra articular hip disorders; spinal disorders; sciatic; neurological diseases associated with motor abnormalities; fibromyalgia; polyarthralgia or any other rheumatological diagnoses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-8fdmb8	Effects of exercise in postmenopausal women	Data analysis completed	Intervention	2015-04-07	<NULL>	<NULL>	440	Impact of exercise on risk factors in overweight and obese postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-11-30	Universidade Estadual Paulista Júlio de Mesquita Filho de Presidente Prudente - SP	Universidade de Marília	https://ensaiosclinicos.gov.br/rg/RBR-8fdmb8	<NULL>	We included 70 women aged 50-79 years; postmenopausal (no period for at least twelve months); obese (fat percentage&gt; 33%); previously sedentary (&lt;150 minutes per week of moderate or vigorous physical activity in the past six months); all users of the Family Health Unit (USF); and no medical restrictions for physical exercise.	Introduced during the intervention health problems that limit or prevent the implementation of the exercise program; anyone associated with inflammatory responses such as influenza; diseases; recent surgical procedures; and acute arthritis condition; less than 65% frequency in the proposed interventions; not accomplish all assessment procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-8tpphf	Effects of two physical exercise programs on the behavior of physical function and heart and analysis of inflammatory markers and respiratory gases in healthy subjects	Data analysis completed	Intervention	2015-04-13	<NULL>	<NULL>	443	Effects of two physical exercise programs on issues related to the physical, cardiovascular, biological and metabolic functions in healthy subjects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Faculdade de Ciências e Tecnologia  - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Ciências e Tecnologia  - Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-8tpphf	<NULL>	Female subjects; apparently healthy; classified as inactive by the Baecke questionnaire for assessing habitual physical activity; age between 18 and 30 years.	"Being a smoker; making consumption of alcohol, 
drugs or medication; do not use contraceptives; have some disease; 
inflammatory process; presenting amenorrhea; 
episode of muscle-tendon injury or joint injury in the upper, lower limbs and / or column."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-7c7ndt	Arthrotomy versus arthroscopy in the treatment of septic arthritis in adults knee joint: a randomized clinical trial with a 24-month follow-up	Data analysis completed	Intervention	2015-04-29	<NULL>	<NULL>	458	Open approach versus Arthroscopy surgery in the treatment of articular infection of the knee in adults: a randomized clinical trial with a 24-month follow-up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-01	Casa de Saúde Santa Marcelina	Casa de Saúde Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-7c7ndt	<NULL>	Knee septic arthritis confirmed by clinical and laboratorial exams, and age (patients aged 16 years or more were included). The clinical exam was considered positive for infection when there was pain, hyperemia, local warmth, joint swelling, or limited movement in walking. Synovial fluid collection by puncturing at admittance allowed diagnosis confirmation.	Patients with chronic septic arthritis, i.e., for more than 15 days, fractures, chronic wounds or ulcers in the knee, septic diseases affecting more than one joint, morbidities affecting the ability to walk or to move the knee. Allergic patients or those who could not receive the standard antibiotic therapy for any reason were also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-6pt2n3	Use of medications in preventing sensitivity arising from tooth bleaching.	Data analysis completed	Intervention	2015-04-29	<NULL>	<NULL>	459	Use of medications in preventing sensitivity arising from tooth bleaching.	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-6pt2n3	<NULL>	Patients older than 18 years are included, with good oral and general health, with free maxillary anterior teeth restorations and do not carious lesion present, that have the color of A1 or darker teeth according to the color scale Classical Vita (Vita Zahnfabrik, Bad Säckingen, Germany).	"Patients who already underwent tooth whitening, pregnant or lactating patients, who report tooth sensitivity, severe browning (staining tetracycline, fluorosis or endodontics), with parafunctional habits, patients with dental prostheses and appliances Orthodontic and any other oral pathology will be deleted. Still be excluded patients who have systemic symptoms such as problems 
stomach, heart, kidney and liver, diabetes, hypertension or who are making continuous use of any medication with analgesic action 
and anti-inflammatory"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5qyjfr	Passion fruit effect on the central nervous system	Data analysis completed	Intervention	2015-05-05	<NULL>	<NULL>	460	Passion Fruit effect on the central nervous system	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2014-04-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5qyjfr	<NULL>	90 Individuals of both sexes; aged between 18 and 59 years; healthy self-appointed; residence in João Pessoa-PB, signing the free and informed consent term.	Subjects with any somatic or mental disorder diagnosed; pregnant women; individuals with chronic use of drugs, including drugs / substances that interfere in the degree of anxiety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-538g6x	The Pilates method increases respiratory muscle strength and perfomance and abdominal muscles thickness	Data analysis completed	Intervention	2015-05-05	<NULL>	<NULL>	461	Analysis of the thickness of the transversus abdominis muscle and respiratory muscle strength after application of the Pilates method	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-23	Centro Universitario Metodista, do Ipa	Prana Academia	https://ensaiosclinicos.gov.br/rg/RBR-538g6x	<NULL>	Woman physically inactive for at least six months without any experience in the Pilates method with no history of back pain or other condition which may influence abdominal muscle activity and signed an informed consent form	Pregnant women, smokers, obese, suffering from abdominal wall hernia, glaucoma, respiratory disease diagnosed, individuals who possess some skeletal muscle dysfunction and or respiratory diagnosed influencing the proposal from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-6p8bhk	Exercises to improve posture in 10 to 13 year-old females	Data analysis completed	Intervention	2015-05-07	<NULL>	<NULL>	462	Relation between holistic gymnastics and posture in 10 to 13 year-old females	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-08-02	Universidade Estadual de CampinasUNICAMP	Universidade Estadual de CampinasUNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-6p8bhk	<NULL>	Age between 10-13 years; female gender; to sign the Informed Consent Form (ICF).	Sequel of orthopedic, rheumatic or neurological disease; Use of prosthetic limbs; pain during practice of physical activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-2skhs4	Evaluation of improvement of fatigue in the legs and feet	Data analysis completed	Intervention	2015-05-08	<NULL>	<NULL>	464	Evaluation of clinical efficacy and perceived improvement of fatigue in the legs and feet	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2013-01-21	Medcin Instituto da Pele	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-2skhs4	<NULL>	"Pregnancy  between 12th and 30th week with a history of Chronic Venous Insufficiency with complaints of episodes of edema, fatigue and heaviness in the legs and feet; agreement to abide by the procedures of the trial and attend the clinic in the days and schedules 
determined for the application and readings and Signing the consent form"	Use of the following medications topical or systemic use: immunosuppressants, antihistamines, NSAIDs and corticosteroids within 30 days before the selection or considering immunosuppressants, the interval should be 3 months before screening; atopic or allergic to cosmetics history; active skin conditions in the assessment area; skin marks in the experimental area that interfere with evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, nevus aplenty, sunburn; pathologies that cause immune suppression, such as diabetes, HIV, endocrine diseases such as thyroid, ovarian or adrenal gland disorders; volunteers with known congenital or acquired immunodeficiency, relevant medical history or current evidence of alcohol or other drugs; known historical or suspected intolerance to products of the same category; intense sun exposure until 15 days before evaluation; aesthetic or dermatologic treatment in the assessment area up to 04 weeks before screening; professionals directly involved in the study design; other conditions considered by the evaluator as reasonable for medical disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-893zqw	Evaluation of improvement of fatigue in the legs and feet	Data analysis completed	Intervention	2015-05-14	<NULL>	<NULL>	473	Evaluation of clinical efficacy and Perceived Improvement of fatigue in the legs and feet	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-12-03	Medcin Instituto da Pele	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-893zqw	<NULL>	"Volunteer female; aged 35-65 years with a history of Chronic Venous Insufficiency; with complaints of episodes of edema, fatigue and heaviness in the legs and feet, agreement to abide by the procedures of the trial and attend the clinic in the days and schedules 
determined for the application and readings and Signing the consent form"	"Pregnant; lactating or planning to become pregnant during the study period; use of the following drugs of topical or systemic use immunosuppressants, antihistamines, NSAIDs, and corticosteroids within 30 days before the selection or considering 
immunosuppressants, the interval should be 3 months before screening; atopic or allergic to cosmetics history; pathologies and / or active skin lesions in the area of review (local and or / disseminated); skin marks in the experimental area that interfere with evaluation of possible skin reactions 
(vascular malformations, scars, increasing hairiness, nevus aplenty, sunburn); diseases which cause immune suppression, such as diabetes, HIV; 
endocrine disorders such as thyroid, ovarian or adrenal gland disorders; volunteers with congenital or acquired immunodeficiency known; relevant medical history or current evidence of alcohol or other drugs; 
History known or suspected intolerance to products of the same category; intense sun exposure up to 15 days before evaluation; or dermatological aesthetic treatment in the assessment area up to 04 weeks before screening; 
professionals directly involved in the study design; other conditions considered by the medical examiner as reasonable for disqualification from participation in the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-58jw26	The efficacy of Distraction Technique to relieve pain in hospitalized children	Data analysis completed	Intervention	2015-05-18	<NULL>	<NULL>	481	The Distraction Technique in relieving pain and reducing stress in hospitalized children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-27	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-58jw26	<NULL>	Children aged between six and 12; who had language skills to communicate; in hospital context with different diagnoses; requiring prescribed venipuncture or arterial puncture by clinical demand; with time minimum of one day of hospitalization and time interval of no more than seven days between the puncture procedures.	Children with neurological impairments; children with communication problems; children under sedation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-6673s5	Population survey on the prevalence of cardiovascular disease - multidisciplinary intervention in adults with  hypertension	Data analysis completed	Intervention	2015-05-25	<NULL>	<NULL>	486	Population survey on the prevalence of risk and protective factors for cardiovascular disease in the metropolitan region of Maringá	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-16	Universidade Estadual de Maringá	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-6673s5	<NULL>	Medical certificate of fitness to practice physical exercises; interest and willingness to regularly attend the activities of the intervention; accepting perform all physical and biochemical evaluations on two occasions (before and after the start of the activities of the GI)	Presenting disability to carry the exercise; do not accept accomplish all assessment proposals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-85gzsj	Effect of Music on Weight Gain of Premature Infants	Data analysis completed	Intervention	2015-05-26	<NULL>	<NULL>	488	The effect of Music on weight gain of Premature hospitalized infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-26	Universidade Federal de São Paulo	Maternidade Escola Santa Mônica	https://ensaiosclinicos.gov.br/rg/RBR-85gzsj	<NULL>	"Preterm infants with post-conceptional age greater than or equal to 32 weeks.
Normal hearing by evoked otoacoustic emissions bilaterally.
Normal vision by visual assessment and examination of the fundus bilaterally"	"Presence of severe hypoxia, intracranial hemorrhage, pulmonary,cardiac, and neurological problems, malformations and syndromes
Presence of clinical complications during the study period, as signs of respiratory distress, diarrhea or reflux"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-7yx9hd	Evaluation of brief intervention for smoking: pilot study of a randomized clinical trial	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	490	Cost-effectiveness evaluation between two approaches to treatment of smoking in the SUS (Unified Health System): brief intervention and intensive approach to the smoker	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-24	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7yx9hd	<NULL>	Daily use of cigarettes for at least one year; Be at least 18 years old; Provide permanent address and phone for contact; Agree to be allocated to one of the groups and to participate in the three- and six-month follow-ups;sample size target 80 people.	Failure to understand the instruments used; Presenting Psychotic Syndrome, Mood disorder with psychotic features; Manic or hypomanic episode; suicide risk (moderate or severe), and dependence on alcohol or other drugs (besides nicotine).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-7drnzt	Diminution of fasting in cirurgia using carbohydrate.	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	494	Comparison of parameters of respiratory strength in postoperative elective cholecystectomy by laparotomy when respected conventional fasting and 2 hours fasting.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Federal do Mato Grosso - UFMT	CAPES- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-7drnzt	<NULL>	Patients with an indication for cholecystectomy by laparotomy and rachianesthesia; aged 18 to 60 years; with body mass index (BMI) ranging from 18.5 to 29.5 kg/m²; ASA I and II and Subjective Global Assessment (SGA) A.	Requiring  cholecystectomy with bile duct exploration; patients who underwent surgery with operative time greater than 120 minutes or whose anesthesia had to be converted to general anesthesia; needing immediate surgical reintervention; patients with complications in the postoperative period; pregnant patients and those with diabetes; hypertension; lung disease; heart disease; arthritis and gastroesophageal reflux disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-8g9dbc	Association of the elastic bandage to Manual Therapy in the neck pain	Data analysis completed	Intervention	2015-06-01	<NULL>	<NULL>	496	Association of the Kinesio Taping to Manual Therapy in the neck pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Faculdade Integral Diferencial	Multifisio Clínica de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8g9dbc	<NULL>	Target sample of 10 volunteers of both genders who sought physiotherapy service complaining of neck pain and age between 21 and 30 years	Historic injury in cervical whiplash; diagnosis of pathologies associated like neoplasia and thrombosis; presence of open wounds; allergies to bandage; use of drugs a week before the study or during its accomplishment and that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6ffm72	Effects of exercise on nerve action that controls the muscle fibers and blood vessels of patients with pre-dialysis chronic kidney disease	Data analysis completed	Intervention	2015-06-05	<NULL>	<NULL>	501	Effect of aerobic exercise on muscle sympathetic nerve activity in predialysis chronic renal	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Faculdade de Medicina da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ffm72	<NULL>	21 Men and women; between 30 and 60 years; Without participation in structured physical activity; not obese; nondiabetic. They were divided into 2 groups: Control (normotensive patients) and Chronic renal disease, stage III (creatinine clearance 30 to 60 mL / min / 1.73m2, hypertensive controlled in use of angiotensin converting enzyme inhibitors or  Angiotensin receptor antagonists).	Patients with anemia; in the chronic kidney disease group, we excluded patients who were taking beta-blockers and sympatholytic. And also with creatinine clearance &lt;30 and&gt; 60 mL / min / 1.73m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-5yr2yx	Alterations in gastric mucosa of cirrhotic patients	Data analysis completed	Observational	2015-06-11	<NULL>	<NULL>	515	The effect of portal hypertension on elevated gastric antrum erosions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo - FCMSCSP	Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-5yr2yx	<NULL>	The study included 69 volunteers of both sexes; from 18 to 80 years of age; presenting elevated antral erosions during endoscopy; with or without portal hypertension.	The volunteers who had prior treatment to eradicate Helicobacter pylori; who had recently used antibiotics or who have not agreed to participate in the study were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8fz3mj	Study of the profile and the effects of an exercises program in patients candidates for liver surgery and liver transplantation	Data analysis completed	Intervention	2015-06-12	<NULL>	<NULL>	516	Study of the profile and the effects of an intervention program in patients candidates for liver surgery and liver transplantation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-10	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8fz3mj	<NULL>	We included 37 patients who were on the waiting list for liver transplantation diagnosed with cirrhosis of any etiology; of both genders; over the age of 18; with or without the diagnosis of cardiorespiratory disorders associated with any value and MELD. These patients participated in the intervention group.	Patients who were unable to understand verbal commands due to the important encephalopathy were excluded; who failed to carry out evaluations; diagnosed with severe acute liver failure and those who were called to transplantation or patients participating in the intervention group who died.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-46487k	The impact of educational videos to teaching of the Leprosy disease to medical students.	Data analysis completed	Intervention	2015-06-23	<NULL>	<NULL>	523	Educational virtual objects assessment inserted in learning based on team (team-based learning) in leprosy education on undergraduate medical setting	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-27	Universidade Federal do Mato Grosso do Sul (UFMS)	Universidade Federal do Mato Grosso do Sul (UFMS)	https://ensaiosclinicos.gov.br/rg/RBR-46487k	<NULL>	94 Healthy volunteers; both genders; age greater than 18 years.	Student who already had take part on dermatologic research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-57355w	Evaluation of a new protocol of neuromuscular electrical stimulation.	Data analysis completed	Intervention	2015-06-23	<NULL>	<NULL>	524	Evaluation of safety and feasibility of a neuromuscular electrical stimulation protocol in ICU: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-18	Associação Teresinense de Ensino SC LTDA	Paulo Eugênio Silva	https://ensaiosclinicos.gov.br/rg/RBR-57355w	<NULL>	"Patients older than 18 years undergoing  mechanical ventilation; APACHE II Score higher than 13. 

Target sample of 40 patients."	"Pregnancy; obesity (body mass index &gt;35 kg/m2); preexisting neuromuscular disease (e.g. myasthenia Gravis; Guillain-Barré disease); diseases with systemic vascular involvement such as systemic lupus erythematosus; bone fractures
or skin lesions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-84b9cd	Effect of clonidine on the target dose of propofol: bispectral index evaluation	Data analysis completed	Intervention	2015-06-25	<NULL>	<NULL>	527	Effect of clonidine on the target dose of propofol: bispectral index evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-15	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-84b9cd	<NULL>	"Patients ASA I or II.
Scheduled for laparoscopic cholecystectomy or jaw fracture treatment in Cariri Regional Hospital. Signing the consent form.
Age between 15 and 65 years. Sample : 51 patients."	"Drug users who can interfere in the outcomes.
Drug Addicts.
Physical state above two.
Refusal to sign the Instrument of Consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-6dwy85	Comparison of physiological responses between different functional tests in obese	Data analysis completed	Observational	2015-06-25	<NULL>	<NULL>	530	Reproducibility of maximum and submaximal exercise tests in obese subjects using a gas analyzer by telemetry system	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-01	Universidade Federal do Rio Grande do Norte	Selma Sousa Bruno	https://ensaiosclinicos.gov.br/rg/RBR-6dwy85	<NULL>	Individuals of both sexes, different degrees of obesity; I, II and III, aged between 18 and 60 years, sedentary or active, no deficit in the locomotor system and or changes in the reported balance or detected on physical examination and spirometric function preserved; FVC&gt; 80%	Exclusion was determined when the testing protocol is not finalized within the given deadline, difficulty in understanding and carrying out the tests or when and musculoskeletal limitations or pain prevented the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-9jknqq	Assessment of preventive use of non steroidal antiinflammatory on increased pain sensibility  after third molar extraction	Data analysis completed	Intervention	2015-06-29	<NULL>	<NULL>	534	Assessment of preemptive use of non steroidal antiinflammatory on hyperalgesia after third molar extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-13	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9jknqq	<NULL>	Patients older than 18 years who agree to participate in research, with good general health,  without any medicine intake in the last 15 days (except contraceptives),  patients who have indicated bilateral extraction of impacted lower third molar, in similar conditions on both sides.	Patients who do not want to participate in the study, patients who have used any drug in the last 15 days (except contraceptives), pregnancy, breastfeeding, and presence of pericoronitis related to lower third molar, patients who report history of allergies or adverse drug effects used in the study, actual or past history of ulcer disease or gastrointestinal bleeding, renal failure, advanced liver disease and coagulopathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-5vr3vt	Pilates and therapeutic exercises are effective for the treatment of low back pain?	Data analysis completed	Intervention	2015-07-06	<NULL>	<NULL>	536	Effectiveness of mat Pilates and therapeutic exercise in the treatment of chronic nonspecific low back pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-05-29	Universidade Paulista UNIP	Clínica Luz Fisioterapia LTDA. ME.	https://ensaiosclinicos.gov.br/rg/RBR-5vr3vt	<NULL>	Patients with low back pain lasting symptoms from at least three months; aged between 18 and 60 years.	Practitioners of Pilates; pregnancy; history of fractures of the spine; inflammatory disorders; tumors; severe neurological impairment; inability to speak or write in Portuguese; pretreatment physical therapy for chronic non-specific pain in the last	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-4fxqw5	Analysis of memories about injuries in the football in adolescents	Data analysis completed	Observational	2015-07-09	<NULL>	<NULL>	539	Analysis of recall bias information about injuries in the football  in adolescents	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-07-30	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Ciências e Tecnologia. Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4fxqw5	<NULL>	Aged 12 and 18 years; male gender; they make effective portion of the sports season (this year).	Inability to practice sports physical activity in the past six months; refuse to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-6vkcb7	Effects of an Educational Action on Knowledge and the Cardiovascular Health Behavior of Men Metallurgical	Data analysis completed	Intervention	2015-07-13	<NULL>	<NULL>	542	Evaluation of an educational program on injury prevention cardiovascular diseases on human health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-18	Universidade Estadual de Maringá	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-6vkcb7	<NULL>	135 metallurgical workers were evaluated and the inclusion criteria for the evaluation are: being male; be aged between 18 and 70 years; being actively working on a metallurgical company selected in Metropolitan area of maringá-PR	Being out of the company and/or vacation during the recruitment period;refuse to participate in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-9p5q67	Land and aquatic strength exercises for obese old women with muscle weakness.	Data analysis completed	Intervention	2012-02-01	<NULL>	<NULL>	544	Land-based versus aquatic resistance therapeutic exercises for old women with sarcopenic obesity: a randomized trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-10	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9p5q67	<NULL>	Female gender; age from 65 to 80 years; obesity (body mass index equal or more than 30 kg/m2); sarcopenia (hand-grip strength equal or lower than 21 kilograms)	Physical, sensory or cognitive disfunctions that do not allow participation in the exercise programs; cardiovascular, articular or metabolic disease in acute phase or not clinically controlled;urinary or fecal incontinence; contagious dermatologic diseases; open scars; physical therapy for lower limbs; fracture or surgery for lower limbs in the last 12 months; severe venous insufficience.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-4kdm85	Elastic bandage for postural correction	Data analysis completed	Intervention	2015-07-27	<NULL>	<NULL>	561	Effects of therapeutic elastic bandage for postural correction	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Faculdade Integral Diferencial-FACID/DeVry	Faculdade Integral Diferencial-FACID/DeVry	https://ensaiosclinicos.gov.br/rg/RBR-4kdm85	<NULL>	Sample consisting of 10 students aged between 18 and 30 years old with protraction of shoulders; thoracic hyperkyphosis and musculoskeletal pain in the thoracic region	Acute pain; chest pain associated with diseases; vestibulopatias; allergic process to bandage and participants who were performing some other type of postural treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-5x4dc9	Asthma control evaluation with inhaled  corticosteroid spray aided by non valved homemade spacer.	Data analysis completed	Intervention	2015-07-28	<NULL>	<NULL>	564	Asthma control evaluation with inhaled  corticosteroid spray aided by non valved homemade spacer.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-07-26	Pós Graduação em Ciências da Saúde da Universidade Federal de Pernambuco	Pós Graduação em Ciências da Saúde da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5x4dc9	<NULL>	180 Volunteers with asthma poorly or partially controlled as defined by GINA (Global Initiative for Asthma); aged between 18 and 65; who had inhaled corticosteroid prescription for daily use by the attending physician.	Patients unable to use the inhaled drug due to motors or mental problems; with other lung diseases diagnosed or reported; who can not perform spirometry, unable to properly use the homemade or commercial spacers after watching educational film three times; patients who refuse to participate and sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-63xqkg	Evaluation of lower limb motor function and balance between 2 rehabilitation protocols using the technique of Used Forced Therapy  at post stroke	Data analysis completed	Intervention	2015-08-13	<NULL>	<NULL>	581	Functional and stabilometric correlates between two Forced Use Therapy protocols in lower limb rehabilitation of patients with Chronic Hemiparesis Post-Stroke	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-10	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Centro Integrado de Reabilitação do Hospital Estadual de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-63xqkg	<NULL>	"Subjects post stroke; 18 until 90years; good cognition; no joint locks; good range of motion in the arm with a minimum of 20 ° of active wrist extension and 10 ° at the metacarpophalangeal joint; ability to walk without assistance.
Sample Target: 36 subjects"	Subjects with: cardiac arrhythmias; uncontrolled hypertension;  severe cardiovascular problems;  severe breathing and inability to attend the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-2cctcn	Study with use of gastrin releasing peptide in children with autism	Data analysis completed	Intervention	2015-08-17	<NULL>	<NULL>	584	Experimental Study of a Case Series of Gastrin-releasing Peptide use in Pediatric Patients with Autism	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-03	Fundo de Investimento a Pesquisa e a Eventos do Hospital de Clínicas de porto Alegre	Fundação Sul-Americana para o Desenvolvimento de Drogas Anti-Câncer	https://ensaiosclinicos.gov.br/rg/RBR-2cctcn	<NULL>	Diagnosis of infantile autism by the criteria of the Diagnostic and Statistical Manual of Mental Disorders, aged between 3 and 18; CT scan or MRI of normal brain; karyotype and normal research Fragile X;	"Conditions associated with an increased acid secretion in the gastrointestinal tract such as gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis; diabetes; heart disease;
 residence outside of Porto Alegre and the metropolitan area; secondary autism to genetic disorders or sensory deficits;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-8h32gy	Effect of intensity of electric current and evidence of blinding method	Data analysis completed	Intervention	2015-08-17	<NULL>	<NULL>	590	Effect of intensity of interferential current and validation of the placebo method	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-15	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8h32gy	<NULL>	Healthy subjects; 18 to 60 years of age.	Participants with peripheral nerve injury in the upper limbs; presence of pain in the upper limbs; pregnancy; chronic diseases; use of cardiac pacemaker; epilepsy; allergy to the material of the electrodes; current use of analgesic medication or in the last seven days; altered skin conditions or loss of sensation in the established areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-2hxj58	Effect of physical therapy in the treatment of knee osteoarthritis	Data analysis completed	Intervention	2015-08-18	<NULL>	<NULL>	594	Effects of different physical therapy protocols on knee osteoarthritis treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-12	UNESP - Faculdade de Medicina de Botucatu	FAI - Faculdades Adamantinenses Integradas	https://ensaiosclinicos.gov.br/rg/RBR-2hxj58	<NULL>	Aged 60 and over; both sexes; diagnosis of OA in one knee and the functional class I, II and III according to clinical and radiographic criteria of the American College of Rheumatology	Associated disease that primarily affects the lower limbs (ankylosing spondylitis; rheumatoid arthritis; neurological diseases); surgical history on his knees in the last year; physical therapy the past six weeks; contraindications to the aquatic and terrestrial service; osteoarthritis functional class IV according to clinical and radiographic criteria of the American College of Rheumatology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-6wvpjq	Effects of substances used after dental bleaching	Data analysis completed	Intervention	2015-08-07	<NULL>	<NULL>	598	In situ and in vivo study of bioactive agents effects on bleached enamel	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-04	Faculdade de odontologia da Universidade Federal do Pará	Faculdade de odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6wvpjq	<NULL>	60 people aged between 18 and 26 years; any genders; good health; non-smoking; pH and salivary flow within normal limits; healthy  teeth and initial color A2 or darker according to the Vita scale.	Having received previous dental bleaching ; restorations on the anterior teeth; pregnant or nursing women; having teeth darkened by tetracycline, fluorosis or endodontic treatment; patients with teeth grinding; having non-carious cervical lesion; and dentin hypersensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-283zts	Haemodynamic effects of manual hyperinflation associated to PEEP in patients with septic shock	Data analysis completed	Intervention	2015-08-13	<NULL>	<NULL>	603	Haemodynamic effects of manual hyperinflation associated to PEEP in patients with septic shock	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Hospital São Lucas da Pontificia Universidade Catolica do Rio Grande Do Sul	Hospital São Lucas da Pontificia Universidade Catolica do Rio Grande Do Sul	https://ensaiosclinicos.gov.br/rg/RBR-283zts	<NULL>	32 adult patients were included with septic shock who require the deployment catheter pulmonary artery; which signed the informed consent form and do not present any exclusion criteria.	Patients under the age of 18 years or over 80 years; pregnancy; acute myocardial infarction 3 months before the study; septic shock secondary to pulmonary disease; severe heart disease; with fractions of less than 30% ejection; and expectancy of less than 24 hours life.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-8cq282	Use of Gastrin-Releasing Peptide in Children with Autism Diagnosis	Data analysis completed	Intervention	2015-09-08	<NULL>	<NULL>	607	"Use of Gastrin-Releasing Peptide in Pediatric Subjects with diagnosis of Autism.
Study of cross-over, randomized, placebo-controlled, proof of concept for the evaluation of safety, tolerability and efficacy"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Programa de Pós-Graduação em Saúde da Criança e Adolescente - Universidade Federal do Rio Grande do Sul	Rudimar dos Santos Riesgo	https://ensaiosclinicos.gov.br/rg/RBR-8cq282	<NULL>	Autism Diagnostic according to DSM-5 criteria, as confirmed by the investigator&apos;s judgment; Age between 3 and 9 years; Normal Neuroimaging (computed tomography or magnetic resonance imaging of the skull); Normal Genetic research (karyotype for girls; karyotyping and Fragile X research for boys); Subjects of use of psychopharmacological treatment considered appropriate by the investigator on a stable dose for at least 4 weeks before inclusion, without adjustment of the dose throughout the study;	History of diabetes mellitus; Secondary autism presence or diseases with features common to autism, as follows: diagnosis of fragile X syndrome, Rett syndrome, Angelman syndrome, Prader-Willi syndrome and Smith-Lemli-Opitz syndrome, Tuberous Sclerosis; Be carrier of any condition associated with increased acid secretion in the gastrointestinal system (gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis); History of heart disease; Any guy whose basic medication require dose adjustment or interruption; Any condition that, in the opinion of the investigator, would put the security of the individual at risk after exposure to the test substance; Reside outside the city of Porto Alegre and the metropolitan area; Parents or guardians refuse to sign the free and informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-93ykhs	Behavioral and educational intervention: effects on return visit rates to receive the results of the Pap smear	Data analysis completed	Intervention	2015-09-15	<NULL>	<NULL>	613	Behavioral and educational intervention: effects on adherence of women to return visit to receive the results of the Pap smear	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-09-01	Universidade Federal do Ceará	Centro de Saúde da Família Aída Santos e Silva	https://ensaiosclinicos.gov.br/rg/RBR-93ykhs	<NULL>	"The size of the target shows: 775 women.
The sample selection followed the following eligibility criteria: have initiated sexual activity and perform the Pap smear in the data collection period. Minimum age: 18 years and maximum: 80 years."	As defined exclusion criteria were: present cognitive limitations that prevent them from answering the questionnaire, to participate in educational or behavioral intervention; and we have not done for any reason, cytologic collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-5y9yyc	Impact of upper limbs exercises protocol on gait of children with Cerebral Palsy	Data analysis completed	Intervention	2015-09-17	<NULL>	<NULL>	619	Impact of upper limbs exercises on gait of children with Cerebral Palsy: a pilot trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Associação de Assistência à Criança Deficiente	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5y9yyc	<NULL>	Children with clinical follow-up at AACD; diagnosed with spastic diplegic cerebral palsy; age between 3 and 13 years old; using type of gait aid; classified  level III of GMFCS (Gross Motor Function Classification System); able to attend the institution twice times a week; with 5 subjects for each group (total of 15 subjects).	Patients with less than 6 months of orthopedic surgical procedure and less than 3 months of neuromuscular blocking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-98x6b5	Does the &quot;mediterranization&quot; of a Brazilian meal induce cardiovascular and metabolic benefits?	Data analysis completed	Intervention	2015-09-20	<NULL>	<NULL>	620	Does the &quot;mediterranization&quot; of a Brazilian meal induce cardiometabolic benefits?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-15	Faculdade de Saúde Pública, Universidade de São Paulo	Faculdade de Saúde Pública, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-98x6b5	<NULL>	"Both sexes, aged between 35 and 69 years
Body mass index  between 25 and 40 kg / m2 with at least one of the following criteria: triglycerides above 150 mg/dl; total cholesterol above 230 mg/dL or LDL-C above 100 mg/dl or plasma fasting glucose between 100 and 124 mg/dl."	live outside the city of São Paulo; pregnant women; patients with neurological problems or severe psychiatric diseases;  use of anti-obesity medication; individuals with cancer, communicable and rheumatic diseases, liver or kidney failure, thyroid dysfunction untreated; a change of more than 5% of body weight within the last six months;  performing some type of diet or modifications to the usual eating pattern.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-964dgy	Effectiveness of physical activity counseling and referral schemes in the leisure time physical activity of an elderly cohort: a randomized controlled trial	Data analysis completed	Intervention	2015-09-30	<NULL>	<NULL>	624	Physical activity promotion programs for the elderly: from diagnosis to action - a proposal for the Primary Health Care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-09-20	Universidade Federal de São Paulo/Setor de Estudos do Envelhecimento	Universidade Federal de São Paulo/Setor de Estudos do Envelhecimento	https://ensaiosclinicos.gov.br/rg/RBR-964dgy	<NULL>	142 people aged over 60 who were part of EPIDOSO / UNIFESP Project were included; who answered the International Physical Activity Questionnaire - IPAQ at baseline (2008 and 2009) and had no impediments to regular physical activity.	Have not performed the evaluation with the International Physical Activity Questionnaire - IPAQ at baseline (2008 and 2009); have impediments to regular physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-2bm36r	Comparison of Cough Assist and Endotracheal Suctioning in airways hygiene of patients in mechanical ventilation	Data analysis completed	Intervention	2015-10-04	<NULL>	<NULL>	626	Comparison of Cough Asisst and Endotracheal Suctioning in bronchial hygiene of patients undergoing mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-17	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-2bm36r	<NULL>	The sample consisted of 43 individuals. Inclusion criteria were patients of both sexes; 18 years; who were on mechanical ventilation for more than 48 hours; with no trauma face and hemodynamically stable.	Were defined as exclusion criteria: history of pulmonary emphysema; presence of barotrauma; thrombocytopenia and impossibility of applying some of the techniques.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-4tdvt9	Early exercise in patients with artificial breathing	Data analysis completed	Intervention	2015-10-13	<NULL>	<NULL>	629	Early mobilization of critical patients in mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-12	Hospital de Clínicas de Porto Alegre - HCPA	Hospital de Clínicas de Porto Alegre - HCPA	https://ensaiosclinicos.gov.br/rg/RBR-4tdvt9	<NULL>	Patients in invasive mechanical ventilation for 72 hours.	Neuromuscular disease; stroke; multiple sclerosis; amyotrophic lateral sclerosis; myasthenia gravis; Guillain Barré; extubated within 48 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-4c2jy8	Identification of coping skills used by alcohol users who wish to stop using by telephone assistance	Data analysis completed	Intervention	2015-10-22	<NULL>	<NULL>	638	Identification of coping skills used by alcohol users in the withdrawal process in a telephone counseling service	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-01	Universidade Federal de Ciências da Saúde	Universidade Federal de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4c2jy8	<NULL>	"Alcohol users who used at least once in the past year with or without the licit or illicit drugs capable of understanding the reading of the survey instrument and who accept participate in the study after oral exposure of the free and informed consent (IC) .
Sample size target is 105 particpantes
Maximum age 90 years
Minimum age 18"	Individuals will be excluded who do not understand the questions; those who are high on drugs at the time of interview and those who refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-5zm9pr	Effects of the Open Lung Concept following ARDSnet Ventilation in Patients with Early ARDS	Data analysis completed	Intervention	2015-11-04	<NULL>	<NULL>	647	Evaluation of a Sequential Ventilatory Strategy in Patients with Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-04	Universidade de São Paulo	Hospital Copa Dor	https://ensaiosclinicos.gov.br/rg/RBR-5zm9pr	<NULL>	Patients with the diagnosis of Distress Respiratory Syndrome presenting PaO2/FIO2 lower than 300 mmHg after 30 min of mechanical ventilation with a PEEP of 5 cmH2O and an FIO2 of 1.0 and a VT ranging from 8 to 10 mL/kg of ideal body weight along with hemodynamically stable parameters (mean arterial pressures higher than 65 mmHg and arterial lactates lower than 3 mg/dL) over the preceding 6 hours.	Patients with the diagnosis of Adult Distress Syndrome for more than 48 h. Diagnosis of pneumothorax. Diagnosis of pneumomediastinum. Bronchopleural fistula. Subpleural blebs. Increased intracranial pressure. Body weight greater than 140 kg. Pregnancy. Coexistent disease with an expected 6-month mortality risk exceeding 50%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-9dxp3k	Efficiency to electric stimulation combined with physical exercise in patients bearers of face pain.	Data analysis completed	Intervention	2015-11-16	<NULL>	<NULL>	652	Effectiveness of transcranial direct current stimulation combined with kinesiotherapy in patients with chronic temporomandibular disorders (TMJ): clinical, randomized, double-blind, placebo controlled.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-04	Irmandade Santa Casa de Misericórdia de São Paulo	Irmandade Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9dxp3k	<NULL>	Person aged between 18 and 60 years; diagnosis of chronic TMD for at least three months, according to the research diagnostic criteria for temporomandibular disorders (Research Diagnostic Criteria for Temporomandibular disorders RDC / TMD); signing the informed consent.	Patients who had: malformations or rheumatologic diseases TMJ; deterioration of articular (signs of arthritis, meniscus dislocation, fractures, tumors or infections), and other causes of pain in the mouth, face or neck (trauma involving area in the past six months, trigemial neuritis, migraine, or herpes zoster in the region); generating the cognitive impairment of communication skills.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-8wk6z9	Survey of oral health conditions in a city of approximately 100,000 inhabitants	Data analysis completed	Observational	2015-12-02	<NULL>	<NULL>	655	Epidemiological survey in a city of approximately 100,000 inhabitants	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-30	Centro Universitário de Lavras	Prefeitura Municipal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-8wk6z9	<NULL>	Volunteers were included in both genders within the 0 age-index to 36 months, 5 years, 12 years, 15 to 19 years, 35-44 years and 65-74 years agreed to participate and signed the Informed Consent (Term Informed Consent)	They excluded those who, for some reason, did not sign the TLCE (Informed Consent and Informed) or did not wish to participate and those who did not have any age surveyed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-3sc9zc	Impact of training with video games in a population of children and adolescents with motor disabilities	Data analysis completed	Intervention	2015-12-07	<NULL>	<NULL>	656	Impact of virtual reality training in a population of children and adolescents with cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-13	Universidad de Talca	Telethon Maule, Chile	https://ensaiosclinicos.gov.br/rg/RBR-3sc9zc	<NULL>	Participants with cerebral palsy type spastic diplegia and hemiplegia (male and female); 7-14 years old; Gross Motor Function Classification System (GMFCS) level I and II y volunteers with informed consent and assent	Neurodegenerative diseases &amp; vestibular disorders; mdministration of high and/or moderate doses of anticonvulsants or similar drugs; moderate and severe cognitive impairment; associated impairment of the type visual and auditory uncorrected; osteotendon and muscle previous surgeries in the last 6 months and access Nintendo Wii at home	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-5nskyh	The influence of the pilates method on bone health in older women	Data analysis completed	Intervention	2015-12-18	<NULL>	<NULL>	658	The influence of the method pilates on functional capacity and quality of life and bone turnover in elderly women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-04	Faculdade de Medicina de Botucatu - Unesp	Universidade Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5nskyh	<NULL>	Female participants; of the Open University of the Third Age; aged 60 or older who do not have serious illnesses and who agree and sign the informed consent form.	Decompensated diabetes, severe hypertension, chronic renal failure, liver disease, sequela of stroke, malnutrition, cancer, hyperparathyroidism, hyperthyroidism, severe chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-6zkm5k	Prevention of pancreatic inflammation after endoscopy of the pancreas and bile duct with anti-inflammatory	Data analysis completed	Intervention	2015-12-29	<NULL>	<NULL>	662	Acute pancreatitis prevention after endoscopic retrograde cholangiopancreatography (ERCP) with anti-inflammatory	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2014-03-30	Julio Carlos Pereira Lima	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6zkm5k	<NULL>	Eligible subjects were all adults who were scheduled to undergo ERCP at our institution.	Exclusion criteria were patients with known contraindication to ketoprofen use, active pancreatitis at the time of ERCP, previous ERCP and refusal to enter in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-326msc	Spinal blood supply characteristics: comparison between patients with and without aortopathy.	Data analysis completed	Observational	2016-01-19	<NULL>	<NULL>	687	Adamkiewicz artery characteristics: comparison between patients with and without aortopathy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-10-17	Universidade de Sao Paulo	Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-326msc	<NULL>	Both genders; age more than 18 years; aortic Angio-CT performed with the Aquillion One device at Hospital das Clínicas by predefined protocol; acceptance of terms and exams protocol	Exclusion criteria were previous surgery of the descending aorta, individuals with diseases liable to affect the results due to the presence of collateral circulation (Takayasu’s arteritis, coarctation of the aorta), individuals with paraplegia or tetraplegia, known allergy to the radiological contrast medium, concomitant inclusion in another study in which its protocol could interfere, aortic intramural hematoma and penetrating ulcer of the aorta, refusal to participate and flawed aorta opacification due to technical reasons	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-8pchqf	The results of pharmacist consultations for the patient&apos;s health and health care system economy.	Data analysis completed	Intervention	2016-01-25	<NULL>	<NULL>	693	Pharmaceutical Care in the hypertension: clinical, economic and social impact.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo	Thais Rodrigues Penaforte	https://ensaiosclinicos.gov.br/rg/RBR-8pchqf	<NULL>	Hypertension, over 18 years in treatment.	Previously be gone, cognitive impairment, pregnant and lactating.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-4pp8j6	Effect of exercise and dietary control on muscle strength, cardiorespiratory fitness, blood variables and body composition in postmenopausal women	Data analysis completed	Intervention	2016-01-28	<NULL>	<NULL>	695	Effects of physical training and dietary control on muscle strength, cardiorespiratory fitness, blood biochemical variables and body composition in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4pp8j6	<NULL>	Women; postmenopausal; age between 50 and 79 years at the date of valuation; no physical limitations or any health problems that prevent the implementation of evaluations; possess a medical certificate to perform the cardiorespiratory fitness test, participate in the concurrent training and eating 1.5 ounces per day of taurine;  perform all evaluations; sign the consent form and formal clarification for study participation.	"Hormone replacement therapy; hypertension;
hysterectomy; accumulate three consecutive absences or four non-consecutive absences during the month"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-2wtwjz	Spiritual well-being resulting from passive listening of sacred music in bereaved relatives: randomized controlled trial	Data analysis completed	Intervention	2016-01-28	<NULL>	<NULL>	699	Spiritual well-being resulting from passive listening of sacred music in bereaved relatives: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-21	Programa de Pós-Graduação em Enfermagem na Saúde do Adulto da Escola de Enfermagem da Universidade de São Paulo	Vladimir Araujo da Silva	https://ensaiosclinicos.gov.br/rg/RBR-2wtwjz	<NULL>	To be mourning the death of a loved one (parent or spouse), registered in the Women&apos;s Network Against Cancer of Maringa-PR, whose death has occurred for cancer, there is at least one month and a maximum of 12 months; to have participated in the care process at the end of life of their loved one; to reside in the cities of Maringa-PR, Sarandi-PR or Paiçandu-PR; to be 18 years old or more; to have preserved auditory function; to have preserved language&apos;s function to respond to the Spiritual Well-Being Scale and a semi-structured form.	Family members who moved to another city during data collection; family members who presented hearing loss during the data collection; family members that present, in the course of data collection, cognitive difficulty expressing one&apos;s perceptions; family members who experience the loss of other family members during the data collection period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-48c29w	Effect of strength training in the vascular function of hypertensive elderly	Data analysis completed	Intervention	2016-02-01	<NULL>	<NULL>	707	Effect of strength training in the vasodilatory response of hypertensive elderly: related mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-48c29w	<NULL>	Aged between 65 and 75 years; have not committed any type of regular exercise (more than 2 days per week) over a period of 6 months prior to study entry; have mild essential hypertension (stage I).	Have history or evidence of hematologic disease; peripheral vascular disease; stroke; obesity; diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-95sxqv	Evaluation of related knowledge of pelvic floor, loss of urine and sexual dysfunction among women participating in a pelvic floor educational group	Data analysis completed	Intervention	2015-12-14	<NULL>	<NULL>	708	Evaluation of related knowledge of pelvic floor, urinary incontinence and sexual dysfunction among women participating in a pelvic floor educational group	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-20	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo FMRP-USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo FMRP-USP	https://ensaiosclinicos.gov.br/rg/RBR-95sxqv	<NULL>	Women who are interested in participating in an education group of the pelvic floor. Women capable of interacting in an interview. Women who agree to participate after the clarification of the researchers.	Women who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-44zfmv	Comparison between two physical therapy treatments for patients with limited movement of elbow joint and wrist	Data analysis completed	Intervention	2016-02-03	<NULL>	<NULL>	710	Comparative study of the effects of classical kinesiotherapeutic treatment and its effects coupled with Maitland technique in patients with limited movement of elbow and wrist	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-10	Universidade Federal da Paraiba	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-44zfmv	<NULL>	40 male or female volunteers; age between 18 and 70 years; limited range of motion of the wrist or elbow after upper limb fracture healing.	More than one year after the injury; neurological changes in muscle function.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-49zkm6	Comparison between two methods of caries prevention using two resin-based materials: sealant or infiltrant	Data analysis completed	Intervention	2016-02-17	<NULL>	<NULL>	715	Progression of non-cavitated caries lesions treated with a Resin-Based Selant or a Resin-Based Infiltrant	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-26	Universidade Anhanguera de São Paulo - UNIAN-SP	Universidade Anhanguera de São Paulo - UNIAN-SP	https://ensaiosclinicos.gov.br/rg/RBR-49zkm6	<NULL>	Health volunteers; both genders; aging between 8 and 24 years; molars with intact deep and retentive occlusal fissures to visual inspection; teeth in contact with the antagonist tooth; teeth presenting visual non-cavitated caries lesions located between the enamel and dentin junction and middle one-third of dentin.	Restorations and white spot lesions or cavitations on other tooth surfaces; teeth reported as sensitive to any type of stimulus; physically and mentally challenged volunteers; volunteers with systemic diseases under medication; children with poor oral habits affecting occlusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-7d67hw	Restorations evaluation in primary teeth	Data analysis completed	Intervention	2016-02-26	<NULL>	<NULL>	722	Adhesive restorations in primary molars - a longitudinal clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Centro Universitário Franciscano	https://ensaiosclinicos.gov.br/rg/RBR-7d67hw	<NULL>	Patients aged 6 to 11 years; both genres; bearing teeth with active caries lesions limited to deep dentin / occluded proximal-occlusal surface of primary molars; absence of clinical diagnosis of pulp exposure, fistula, edema of the periodontal tissues and tooth mobility incompatible with stage of root resorption; absence of clinical symptoms of irreversible pulpitis; such as spontaneous pain or pressure sensitivity; the extent of the carious lesion should be such that complete / incomplete removal of decayed tissue not run the risk of pulp exposure as determined by clinical and radiographic evaluation; absence of radiolucencies in the inter-radicular regions (bifurcation) or periapical or thickening of the periodontal spaces which indicate the presence of irreversible pulp pathologies or necrosis; absence of internal or external root resorption.	Pulp exposure during cavity preparation procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-7q2n33	Effect of calcium intake on body weight and body fat in overweight individuals	Data analysis completed	Intervention	2016-03-01	<NULL>	<NULL>	725	Effect of calcium on weight and body composition in overweight individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Federal de Viçosa - UFV	Fundação do Amparo à Pesquisa do Estado de Minas Gerais - FAPEMIG	https://ensaiosclinicos.gov.br/rg/RBR-7q2n33	<NULL>	Healthy overweight or obese women; calcium intake less than 800 mg/day; physical activity level of mild to moderate; aged between 19 and 40 years; non smokers; restriction and disinhibition level less than 14.	Use of calcium or vitamin D supplements or any medication that affects the metabolism of calcium; medications or herbs for weight reduction; adoption of diets for weight reduction; use of drugs for estrogen replacement; weight gain or loss more tran 3kg in the last three months; recent changes in physical activity level; aversion or intolerance to foods used in the study; consumption of alcohol higher than 2 servings a day; presence of eating disorders, endocrine pathology, renal disfunction, hepatic disease or malabsorption syndrome; caffeine intake more than 350mg/day; pregnance; lactance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-2j7hbf	Effects of a shoulder joint strengthening program on muscular balance and throwing	Data analysis completed	Intervention	2016-03-08	<NULL>	<NULL>	741	Effect of shoulder external rotator eccentric strengthening program on strength balance and on throwing speed and accuracy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2j7hbf	<NULL>	Female handball atlhetes volunteers; attended at least one full competitive season; without upper limb injury for at least six months	Volunteers feeling pain; swelling; inability to perform physical exercises; symptomatic or asymptomatic orthopedic injuries associated with upper limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-7qnsh6	Pilates training effects on physical aspects and quality of life in overweight or obese people	Data analysis completed	Intervention	2016-03-08	<NULL>	<NULL>	742	Pilates training effects on physiological responses, health parameters and quality of life in overweight or obese people	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qnsh6	<NULL>	BMI higher than 25 kg/m2; total body mass maximal of 120kg; at least six months without practicing any kind of physical activity.	History of neurological; cognitive; orthopedic; respiratory; or endocrine disease (except obesity)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-7gb4wm	Evaluation of the educational activities in Diabetes in Primary Health Care	Data analysis completed	Intervention	2016-03-09	<NULL>	<NULL>	743	Evaluation of the model of educational activities in Diabetes Mellitus Type 2 in Primary Health Care Units	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7gb4wm	<NULL>	Patients who are diagnosed with Diabetes mellitus type 2; both sexes; age between 30 and 80 years; with access to fixed or mobile phone line.	Patients who are diagnosed  with chronic complications such as diabetic retinopathy; diabetic neuropathy; diabetic nephropathy and amputation. Patients who do not attend  the call for more than five consecutive attempts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-7dp6hs	Effects of three different strength training on mass and muscle strength.	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	747	Effects of isometric, isotonic or isokinetic training on mass and muscle strength.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7dp6hs	<NULL>	Age between 18 and 30; male; no history of knee or thigh injury in the past five years; had not undertaken any leg strength training during the previous six months.	Pain; swelling; inability to do exercises; asymptomatic orthopedic injuries or other pathology that  limits the realization of maximum torque with the lower limbs; female.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-9tphvs	Role of neuromotor training nn gait pattern and mobility of ankles in elderly	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	749	Role of neuromotor training nn gait pattern and mobility of ankles in elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-03	Universidade do Contestado	Universidade do Contestado	https://ensaiosclinicos.gov.br/rg/RBR-9tphvs	<NULL>	gender female,65 to 75 years old,practicing of regular physical activity,sedentary	physical disability;auxiliary device of march;neurological disorders with sequels;severe visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-6srs33	Use a flipchart to promote the mother&apos;s confidence in breastfeeding her child	Data analysis completed	Intervention	2016-03-14	<NULL>	<NULL>	751	Using a flip chart for the promotion of maternal self-efficacy in nursing	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Universidade Federal do Ceará	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6srs33	<NULL>	Women in the immediate postpartum period and after six hours of birth; with 12 or more years of age; mothers admitted to the rooming together with the newborn with good vitality, effective suction capacity and thermal control.	Women who showed clinical complications at the time of data collection; obstetric complications in the postpartum period; mothers with some difficulty understanding and verbal expression that prevented her from participating in the educational intervention or respond to the instruments; maternal infectious condition which prevented or contraindicated breastfeeding; mothers admitted to the rooming with children in the Neonatal Intensive Care Unit; and newborns of mothers who showed abnormalities that precluded or made it difficult breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-8kvgy3	Effects of balance training associated with cardiorespiratory training in the water about the falls risk and funcionality in women	Data analysis completed	Intervention	2016-03-16	<NULL>	<NULL>	755	Therapeutic approach in the quality of life and elderly functionality	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Pontificia Universidade Católica de Goiás	Adriana Marcia Monteiro Fantinati	https://ensaiosclinicos.gov.br/rg/RBR-8kvgy3	<NULL>	Women over 45 years old, participants of UNATI (Universidade Aberta à Terceira Idade) PUC - GO (Pontificia Universidade Católica - Goiás), capable according with the Mini Mental State Examination (MMSE) with score minimum of 17, considering illiterate , 75% presence in cardiorespiratory training in the water and in balance training in solo for a period of three months , who participated in all assessments proposed in the study and signed the Informed Consent and Informed.	Women who did not pass in the screening UNATI (Universidade Aberta a Terceira Idade) PUC - GO (Pontifícia Universidade Católica - Goiás) prior to attending the program, did not participate in Six Minutes Walk Test (6MWT) due the following contraindications: recent electrocardiographic changes; recent myocardial infarction acute ; high resting blood pressure (systolic bigger then 180 mmHg; diastolic bigger then 100 mmHg); unstable angina during the last month; heart rate greater than 120 beats per minute.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-4rcsc6	Strength evaluation after  open surgery for bladder in patients undergoing conventional fasting and fasting with limited time	Data analysis completed	Intervention	2016-03-18	<NULL>	<NULL>	759	Functional assessment after open cholecystectomy in patients undergoing conventional and abbreviated fasting	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-12-05	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-4rcsc6	<NULL>	adult female patients, aged 18 to 60 years old undergoing open cholecystectomy	Younger than 18 years and greater than 60 years, male, other diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-4982b5	Hydrotherapy in low back pain	Data analysis completed	Intervention	2016-03-18	<NULL>	<NULL>	763	Effects of an abdominal progression protocol hydrotherapy in women with low back pain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Faculdade de Fisioterapia da Universidade Católica de Pelotas	Faculdade de Fisioterapia da Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4982b5	<NULL>	Female patients; patients who experience pain in the lower back for at least three months; between the ages of 35 and 55 years.	Patients who have received physical therapy for low back pain in the last two months; patients in pregnancy ; hypertensive patients not controlled ; infectious diseases; genetic disorders ; oncological diseases , neurological diseases ; cognitive changes that do not understand verbal commands ; Phobia water; urinary or fecal incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-4m94g4	Neurosensory analysis of tooth sensitivity during at-home dental bleaching	Data analysis completed	Intervention	2016-03-30	<NULL>	<NULL>	768	Influence of the cold sensation threshold on the occurrence of dental sensitivity before dental bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-10	Faculdade de Odontologia de Araçatuba - Unesp	Faculdade de Odontologia de Araçatuba - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-4m94g4	<NULL>	Volunteers with healthy and vital maxillary teeth; no decayed teeth; no visible enamel defects; no orthodontic brackets; overall good systemic health; healthy oral soft tissue; non-smoking; pacients who have never undergone bleaching treatment.	Direct and indirect restorations in the maxillary anterior region; adverse reaction to peroxide; use of opioids or medications influencing neurosensory response; use of pacemaker; presence of severe dental staining (tetracycline, trauma, fluorosis, and unknown etiology); neurological diseases; chronic or acute diseases; dentine exposure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-6jr5nq	Cardiovascular risk factors assessment and the effect of physical activity and nutritional counseling for children and adolescents.	Data analysis completed	Intervention	2016-04-01	<NULL>	<NULL>	779	Cardiometabolic risk factors assessment and the effect of physical activity for children and adolescents: a continued study.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-09	Universidade Federal de Santa Catarina	Edson Luiz da Silva	https://ensaiosclinicos.gov.br/rg/RBR-6jr5nq	<NULL>	Be enrolled in a public school of the city of Guabiruba-SC, both genders, have abdominal obesity and/or dyslipidemia.	Present preexisting conditions that preclude the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-4hqbmf	Effects of two types of weight training: traditional and blood flow restriction on the strength, power, muscle mass and performance in daily activities in the elderly	Data analysis completed	Intervention	2016-04-04	<NULL>	<NULL>	785	Effects of two types of weight training: conventional and partial restriction of blood flow on the muscle strength and power, muscle quality and functional performance in elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-30	Universidade Federal da Paraíba	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-4hqbmf	<NULL>	"Ages from 55 years; show complete functional independence; be physically active; not perform strength training in the last six months; not have the disease:
arthritis, arthritis, neuropathy, chronic obstructive pulmonary disease; not present cardiac arrhythmias; deep vein thrombosis; not having suffered myocardial infarction within 6 months prior to the intervention period; not reporting muscle or joint injury in the lower limbs; do not use heart pacemaker; submit ankle brachial index situated between 0.90 and 1.40; speed normal pulse wave; Normal central systolic pressure."	Do not get minimum frequency of 75% to the training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-89xvwj	Demographic mapping and characterization of physical therapy care profile offered in neonatal intensive care units in the city of Rio de Janeiro	Data analysis completed	Observational	2016-04-05	<NULL>	<NULL>	787	Characterization of physical therapy profile offered in neonatal intensive care units in Rio de Janeiro City	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-89xvwj	<NULL>	Hospitals offering neonatal intensive care in Rio de Janeiro during the study period.	They were excluded from the study hospitals whose leaders delivered the questionnaires incompletely and hospitals whose ICUs were mixed, that is, also provided assistance to pediatric public.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-8txsrk	Physiotherapy approach to cellulite and preoperative and postoperative abdomen surgery	Data analysis completed	Intervention	2016-04-10	<NULL>	<NULL>	793	Evaluation and Physical therapy in women with fibro geloid edema and preoperative and postoperative abdominoplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8txsrk	<NULL>	Group cellulite: Healthy volunteers; gender female; aged between 18 and 40 years; with asymmetry of cellulite in the gluteus; with pelvic tilting. Group abdominoplasty: Healthy volunteers; gender female; aged between 18 and 40 years; undergoing abdominoplasty.	Group cellulite: pregnant women; those with maintenance impossibility of bipedalism for prolonged periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-275ybt	Effects of Exercise Program on Work Environment	Data analysis completed	Intervention	2016-04-10	<NULL>	<NULL>	794	Effects of Workplace Exercise Program: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-275ybt	<NULL>	Volunteers of both sexes aged between 25 and 50 years; which they were in accordance with the methods and signed the informed consent form ; who worked in the factory production area.	Disability or depressive autorelato .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-244gpz	Influence of exercises performed by physiotherapists in newborns prematuos to improve breathing	Data analysis completed	Intervention	2016-04-12	<NULL>	<NULL>	798	Influence of sensorimotor stimulation of the respiratory system of preterm infants	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-13	Universidade Federal do Mato Grosso do Sul	Hospital Regional de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-244gpz	<NULL>	Gestational age 28semanas up to 36 weeks and 6 days; hemodynamically stable ; over 72 hours of life ; breathing spontaneously and may or may not be with O2 catheter use; no congenital malformations ; minimum weight of 1,100 grams.	Patients with congenital malformations ; hemodynamically unstable ; intraventricular hemorrhage Peri grade III and / or IV ; weight loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-83nfhp	The effect of pilates exercise on vagina strength	Data analysis completed	Intervention	2016-04-14	<NULL>	<NULL>	800	"The influence of the pilates method in the contractility of the pelvic floor muscles of
student at open university to elderly people, unapi/ufms"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-10	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-83nfhp	<NULL>	social volunteers; eutrophic, female; non smokers; age of 50 years; Sedentary and signed an informed consent form.	Women alcoholics; with clinical diagnosis of pelvic floor dysfunction; with a history of urinary tract infection; with history of previous gynecological surgery; with neurological or endocrine-metabolic disorders. Women who are allergic to latex.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-25ck6t	Assessment of balance and muscle function in elderly women with osteoporosis after exercises with vibratory rod	Data analysis completed	Intervention	2016-01-29	<NULL>	<NULL>	801	Analysis of functional balance and electromyographic activity of elderly women with osteoporosis submited of balance training with vibratory rod	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Universidade Estadual Paulista- Faculdade de Filosofia e Ciências	Marcelo Tavella Navega	https://ensaiosclinicos.gov.br/rg/RBR-25ck6t	<NULL>	Older; aged 60-80 years; with osteoporosis diagnosed by bone densitometry examination considering T-Score:equal or less than -2.5 SD; physically active acording to IPAQ which considered moderate and vigorous activities daily and weekly according to 8 answer questions; no pain; no fracture; no severe soft tissue injury in the six months preceding the study; no neurological changes; no cardiovascular changes; no respiratory changes; score upper to 18 points in Mini-Mental State test which considers that guidance notions, immediate memory, attention and calculation, recall and language.	pain, fractures or severe soft tissue injury in the 6 months preceding the study, and neurological, cardiovascular or respiratory diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-8qtdw4	Functionality, muscle strenght and balance in elderly woman after physical exercise and vitamin D supplementation	Data analysis completed	Intervention	2016-04-25	<NULL>	<NULL>	811	Functional capacity, muscle strenght and balance in elderly woman after physical conditioning, water aerobic and vitamin D supplementation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-06-01	Universidade Federal de São Paulo	Maysa Seabra Cendoroglo	https://ensaiosclinicos.gov.br/rg/RBR-8qtdw4	<NULL>	"eldely woman; 60 years of age and older; 
practicing exercise at SESC ;
and sedentary elderly women"	Acute disease; physical dependency; dementia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-69zxf4	Pain and child anxiety perceived during atraumatic and conventional restorative treatments by 5-to 8-yr-old school children	Data analysis completed	Intervention	2016-04-26	<NULL>	<NULL>	813	Perception of pain and anxiety related to atraumatic restorative treatment (ART) and conventional treatment by 5-to 8-yr-old school children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Odontologia e Centro de pesquisas São Leopoldo Mandic	REGINA N M TAVARES	https://ensaiosclinicos.gov.br/rg/RBR-69zxf4	<NULL>	6- to 8-yr-old children with good systemic conditions, have at least two bilateral decayed primary molars with Black&apos;s class-II dentinal caries cavity, without pain,pulp involvement and periapical lesion, signed individual informed consent forms by parents and children, to accept the restorative treatment without local anaesthesia in the dentist appointment day	children under 5 years or over 8 years, have less than two bilateral decayed primary molars in the mouth, teeth with pain, apical lesions, and pulp involvement, use of anesthesia during the procedure on the day of the dentist appointment day, individual informed consent form not signed by the parents or the child	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-8ccym2	Evaluation of the amounts of metal released in saliva of patients undergoing orthodontic treatment with metal or esthetic appliances	Data analysis completed	Observational	2016-04-29	<NULL>	<NULL>	821	Comparative study of the nickel presence in saliva of patients em treatment with metalic or esthetic orthodontic brackets	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade e Centro de Pesquisas São Leopoldo Mandic	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8ccym2	<NULL>	Control groups consisted of patients who had never undergone movable or fixed orthodontic treatment; more than 15 years-old; both genders. Metal group consiste of patients undergoing between one month up to one year of orthodontic treatment; with a fixed appliance composed of stainless steel brackets; with metallic archwire; four metal bands on the permanent molars; more than 15 years-old; a minimum of 20 teeth with orthodontic accessories; without the use of any type of palatine or lingual devices welded to the bands; or auxiliary extra-oral orthodontic appliances; both genders. Esthetic group consisted of patients undergoing between one month up to one year of orthodontic treatment with a fixed orthodontic appliance composed of self-ligating polycarbonate brackets; with metallic archwire coated with esthetic cover; more than 15 years-old; a minimum of 20 teeth with orthodontic acessories; without the use of any type of palatine or lingual devices welded to the bands; or auxiliary extra-oral orthodontic appliances; both genders.	Smokers; patients with metal prosthetic parts; amalgam restorations; or with periodontal disease; those using any type of medication in the 24 hours preceding saliva sample collection; or those with a  history of orthodontic treatment prior to the present treatment; more than 40 years-old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-47v3fh	Effect of overhead respiratory muscle on performance in the six-minute walk test in patients with systolic heart failure	Data analysis completed	Intervention	2016-04-29	<NULL>	<NULL>	824	Effect of respiratory muscle fatigue on performance in the six-minute walk test in outpatients with systolic heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-20	Universidade Federal Fluminense Faculdade de Medicina Hospital Universitário Antônio Pedro	Clínica de Insuficiência Cardíaca Coração Valente Hospital Universitário Antônio Pedro	https://ensaiosclinicos.gov.br/rg/RBR-47v3fh	<NULL>	Patients over 40 years, diagnosed with heart failure with reduced ejection fraction confirmed (Boston criteria), and that part of clinical treatment of heart failure program of the University Hospital Pedro Antonio	Patients with heart rate greater than 120 bpm rest, systolic blood pressure greater than 180 mmHg, diastolic blood pressure greater than 100 mmHg; Malnutrition, as evidenced by a body mass index less than 20 kg / m2; Cold and / or flu in the previous 4 weeks and use of psychotropic drugs, muscle relaxants and immunosuppressants; Inability to walk due to musculoskeletal problems; chest pain previous 4 weeks; cognitive changes that prevent the realization of the Protocol; chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-7699xz	Analysis of walking training with partial weight support for post stroke patients.	Data analysis completed	Intervention	2016-05-04	<NULL>	<NULL>	828	Multidisciplinary analysis of a motor rehabilitation protocol with partial weight support for post stroke patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Pontifícia Universidade Católica do Paraná	Centro Hospitalar de Reabilitação Ana Carolina Moura Xavier	https://ensaiosclinicos.gov.br/rg/RBR-7699xz	<NULL>	"The intended sample of 50 volunteers must satisy the following criteria:
Confirmed stroke; lower limb residual hemiparesis; score 1 to 5 at Functional Ambulation Cathegory; age above 18 years old."	Present sequelae in both sides of the body or bilateral stroke; Diagnosed cardiac condition instable; present another neurological conditions (i.e. Alzheimer, Parkison, dementia, cerebelar disease, severe cerebelar disorders, etc); severe muscoloskeletal lower limb disorders not related to stroke and might interefere in gait; trunk circumference shorter than 36 cm or larger than 142 cm, body mass larger than 138 kg, height larger than 210 cm, due to the limitations of tue body weight support equipment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-2bz6v8	Vocabulary of children with Down syndrome	Data analysis completed	Observational	2016-05-04	<NULL>	<NULL>	829	Receptive and expressive vocabulary of children with Down Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2bz6v8	<NULL>	"Experimental Group (EG): to have a diagnosis of Down Syndrome (Trisomy 21); have been born at term; have not been born with very low weight; have results indicative of normality in the neonatal auditory, visual and metabolism screenings (mainly for congenital hypothyroidism); do not have characteristics of the Autism Spectrum Disorder; have visual skills to carry out the activities proposed; attend rehabilitation procedures since the first trimester of life; be attending regular school (public) and be in the age group between 36 the 62 months of chronological age. 

Comparative group 1 (GC1) and Comparative Group 2 (GC2): to have typical neuropsychomotor development; have been born at term; have not been born with low weight; have results indicative of normality in the neonatal auditory, visual and metabolism screenings; do not have characteristics of the Autism Spectrum Disorder; have visual abilities to carry out the activities proposed; be paired according to gender, mental age (CG1), chronological age (CG2), school and socioeconomic status with the EG."	Presented: congenital hypothyroidism; born with very low weight; born preterm; signals of the Autism Spectrum Disorder; not initiated the rehabilitation procedures early and not attending school.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-83c6y8	A cooldown phase after intense exercise can decrease the incidence of ventricular arrhythmias?	Data analysis completed	Intervention	2016-05-05	<NULL>	<NULL>	831	A cooldown phase after intense exercise can decrease the incidence of ventricular arrhythmias?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-05	Instituto Dante Pazzanese de Cardiologia	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-83c6y8	<NULL>	Any patient presenting complex ventricular arrhythmia in the stress phase of the exercise test.	Patients with cardiac implantable devices; incapacity to keep walking after exercise phase; atrial fibrillation or flutter; technical artifacts in the electrocardiogram.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-63wb6k	Prevalence of risk factors for heart diseases in children and adolescents in Botuverá -SC: a continued study	Data analysis completed	Observational	2016-05-05	<NULL>	<NULL>	833	Prevalence of cardiometabolic risk factors in children and adolescents of Botuverá-SC: a continued study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Santa Catarina	Edson Luiz da Silva	https://ensaiosclinicos.gov.br/rg/RBR-63wb6k	<NULL>	Be enrolled in a public school of the city of Botuverá-SC, both genders.	Not included exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-6npfkm	Evaluation of post-operative pain following use of reciprocating instrumentation technique in root canal treatment.	Data analysis completed	Intervention	2016-05-06	<NULL>	<NULL>	839	Evaluation of post-operative pain following use of reciprocating instrumentation technique in endodontic.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-13	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6npfkm	<NULL>	78 volunteers; male; aged between 18 and 64 years; that already had endodontic treatment indication in permanent molars teeth; diagnosed with necrotic pulp with or without asymptomatic apical periodontitis.	Volunteers at the time of intervention were administering antibiotics or corticosteroids during the treatment; with immunocompromised; which would complicate the systemic disease; these factors could change the perception of pain or interfere with the score analysis of postoperative pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-8xgqzr	Physiotherapy for childbirth preparation	Data analysis completed	Intervention	2016-05-17	<NULL>	<NULL>	850	Role of physical therapy during pregnancy fopr childbirth preparation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-21	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8xgqzr	<NULL>	Women; between 20 and 35 years; primigravidae; belonging to UBS the municipality of Assisi; normoglycemic and normotensive; gestational period of 18 to 36 weeks.	Women; under 18 or over 36 years; multiparous; hypertensive or diabetic; with risk pregnancy indication; women who left to attend the service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-796g9q	Effects of weightlifting and aerobic training on bofy fat and laboratory blood tests in adolescents with overweight and obesity	Data analysis completed	Intervention	2016-05-20	<NULL>	<NULL>	854	Effect of resistance and aerobic training program on body composition, lipid profile and high sensitive c-reactive protein of overweight and obese adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade do Estado do Rio Grande do Norte	Centro Municipal de Controle à Obesidade Jansen Jefferson Diógenes e Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-796g9q	<NULL>	Adolescents of both sexes; aged between 12 and 15 years old; being overweight and obesity according to the cutoff points proposed by the World Health Organization; no history of previous experience with resistance exercises or systematic program of aerobic exercises	Attest use of tobacco, alcohol or other drugs; present some limitation that prevents the execution of any exercise; pregnancy; present endocrineisease; be making chronic drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-7zxk77	Aquatic exercises and health education for the treatment of fibromyalgia	Data analysis completed	Intervention	2016-05-21	<NULL>	<NULL>	856	Hydrotherapy and health education for the treatment of fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Centro Universitário de Formiga - MG (UNIFOR-MG)	Centro Universitário de Formiga - MG (UNIFOR-MG)	https://ensaiosclinicos.gov.br/rg/RBR-7zxk77	<NULL>	women who have a confirmed diagnosis of fibromyalgia by a physician and according to the new diagnostic criteria proposed by the American College of Rheumatology in 2011. Regardless of race; aged between 25 and 60 years; BMI below 30; who read and sign the Consent and Informed (IC) not using drugs for more than three months or with stable pharmacological treatment for more than three months.	women who did not sign the consent form; which violate the data collection protocol; which change the drugs during the study period; using steroidal anti-inflammatory drugs or nonsteroidal; pregnant women; nursing mothers; patients with a history or presence of cancer or diseases autoimmune; psychiatric; infectious and inflammatory or in the period of data collection or in the three months prior to data collection will also excluded patients who do not participate in at least 80% of the activities proposed by the researchers (EIF and Hydrotherapy).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2z5rgg	A study to validate A Glucose-6-Phosphate Dehydrogenase enzyme assay	Data analysis completed	Intervention	2016-05-22	<NULL>	<NULL>	857	A follow-up of validation test protocol enzyme glucose 6-phosphate dehydrogenase ( G6PD ) to study TAF112582	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-24	Fundação de Medicina Tropical do Amazonas	Medicines for Malaria Venture	https://ensaiosclinicos.gov.br/rg/RBR-2z5rgg	<NULL>	"The subject is between 18 and 45 years of age,  male; 
Hgb concentration greater or equal than 12g/dL; 
Reticulocyte count less or equal than 2.5%; 
A signed and dated informed consent from the subject or the subject’s legal representative prior to screening"	"History of haemoglobinopathy; 
Past or current history of methaemoglobinaemia or methaemoglobin percentage above 3%; 
Past medical history of G6PD deficiency; Any other co-morbidity or treatment that, in the opinion of the investigator might
influence haematopoiesis; 
Any person that may have donated blood in the last 56 days"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2w7phk	Postoperative vision assessment after changing one of the steps of laser surgery degree correction	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	859	Influence of the change in the shape of the corneal epithelium removal in postoperative visual acuity in photorefractive keratectomy (PRK)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-2w7phk	<NULL>	Volunteers of both gender ; aged between 18 and 50 years; formal indication for bilateral PRK with preoperative visual acuity of 1.0 in both eyes and the difference between the spherical equivalent refractive error of the eye of each less than 1 diopter .	Patients with known or suspected keratoconus ; with cataracts ; people with corneal diseases ; ametropies greater than 8 negative diopters or greater than 4 positive diopters or greater than 4 cylindrical diopters ; people with amblyopia ; people with strabismus, prior eye surgery history.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-6s72rf	Analysis of intrastromal corneal ring implants in irregular corneas at a reference center in Brazil	Data analysis completed	Observational	2016-05-23	<NULL>	<NULL>	860	Analysis of intrastromal corneal ring implants in ectatic corneas or presenting secondary irregular astigmatism in a reference center in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-20	Universidade Federal de São Paulo - Departamento de Oftalmologia	Taíse Tognon	https://ensaiosclinicos.gov.br/rg/RBR-6s72rf	<NULL>	"All patients who underwent intrastromal corneal ring implantation between November 2009 and December 2012 in Sorocaba Ophthalmological Hospital.
Surgical technique exclusively manual or using fentosecond LASER assistance.
Patients whose implants used were Kerarings of 5mm diameter."	"Incomplete medical records.
Incomplete ophthalmic preoperative evaluation or incomplete preoperative complementary exames (for example previous corneal topography or tomography and pachymetry)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-524z9n	Contributions to Prenatal Care	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	861	Contributions Theoretical and Practical for Prenatal Care for Diabetic Pregnant	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-02	Universidade Federal do Rio de Janeiro - UFRJ	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-524z9n	<NULL>	adult women ( aged 20 to 49 years), diagnosed with diabetes mellitus prior to pregnancy or during pregnancy with gestational age below 28 weeks and, of singleton pregnancy.	diabetic pregnant women with chronic diseases or diabetes mellitus complications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-5jh9sf	Effect of psychological preparation in the preoperative anxiety in children undergoing ambulatory surgery	Data analysis completed	Intervention	2016-05-23	<NULL>	<NULL>	862	Effect of psychological intervention in the preoperative anxiety of preschool children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-06	Faculdade de Medicina de Jundiaí	Faculdade de Medicina de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-5jh9sf	<NULL>	Children of both gender, aged 2-8 years classified as ASA I according to the American Association of anesthesiology, which were attended in the pre-anesthetic assessment clinic of the University Hospital of Jundiaí Medical School and undergoing surgery outpatient at the same hospital.	children with previous surgeries, the ones with confirmed behavioral and cognitive changes, users of psychoactive drugs, patients with history of convulsion, mental illness and chronic pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2vfhfv	Influence of suplementation of different types of fats on heart health.	Data analysis completed	Intervention	2016-05-27	<NULL>	<NULL>	864	LDL and HDL physical and chemical properties, oxidative and cardiometabolic biomarkers may be modulated by consumption of omega-3, omega-6 and omega-9 in individuals with intermediate cardiovascular risk?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-15	Faculdade de Saúde Pública da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2vfhfv	<NULL>	Both sexes, between 30 to 74 years old, medium and high cardiovascular risk.	Malnutrition, prengnancy, previous cardiovascular event, included in other clinical trial, using ilegal drugs, psychiatric alterations, allergic to any compound of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-2mmfhx	Effects of the biometenergy of practitioners of meditation on chronic spine pain	Data analysis completed	Intervention	2016-05-27	<NULL>	<NULL>	865	Effects of the biometenergy of practitioners of pranic meditation on the evolution of chronic diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-02	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2mmfhx	<NULL>	Volunteers, both genders, with back pain longer than 3 months, recent medical report, older than 18 years old, no previous participation of pranic meditation courses and no have any knowledge about the techniques of pranic meditation, and the written informed consent	Smokers; alcohol users; pracitioners of pranic meditation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-47hfqm	Hammock position and nesting in premature babies: a comparative study	Data analysis completed	Intervention	2016-05-30	<NULL>	<NULL>	871	Hammock position and nest in premature infants: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-14	Hospital Materno Infantil de Brasília - HMIB	Kassandra Silva Falcão Costa	https://ensaiosclinicos.gov.br/rg/RBR-47hfqm	<NULL>	"Premature babies with post gestational age between 32-37 weeks design;
Spontaneous breathing in room air;
In heated incubator;
Weight between 1300g and 2000g;
Over 72 hours of life;
Hospitalization in the Neonatal Intensive Care Unit more than 24 hours;
Diuresis present and spontaneous;"	"No injury or bone fracture; 
No apnea history less than 72h;
Baby less than 1 hour of applying the study underwent painful invasive procedures such as punctures and polls;
No involvements diagnostics CNS as cerebral hemorrhages, syndromes with neurological impairment, seizure history and hypertension;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-2q8bzk	The effect of combining breastfeeding plus skin-to-skin contact on the BCG vaccination induced pain in term infants: a randomized clinical trial	Data analysis completed	Intervention	2016-05-31	<NULL>	<NULL>	873	Breastfeeding in skin-to-skin contact in the management of pain during BCG immunization in infants at term : a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-14	Escola de Enfermagem da USP	Hospital Universitário da USP	https://ensaiosclinicos.gov.br/rg/RBR-2q8bzk	<NULL>	The infants who meet the following criteria will be included in the study : Internees in rooming unit; Exclusive breastfeeding without medical records of difficulty to handle and sucking the mother&apos;s womb ; With gestational age between 37 and 41 weeks and 6 days of birth ; Last feed occurring for at least 1 hour before vaccination; BCG vaccination indication; No analgesic use history or sedative; Absence of fractures and tocotraumas ; and absence of nausea or vomiting within the last 2 hours preceding the administration of the BCG vaccine.	Will be excluded from the study newborns who present : Congenital disease diagnosis of the nervous system malformations or neurological damage established after receiving the BCG vaccination; Fracture diagnosis or established tocotraumatism after receiving the BCG vaccine; and application of the vaccine dose or in non-compliance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-5hn7gn	use of minas fresh cheese with probiotics  to control the prevalence of oral candidiasis	Data analysis completed	Intervention	2016-05-31	<NULL>	<NULL>	877	use of probiotics added to minas fresh cheese to control the prevalence of oral candidiasis– double-blind randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-07	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5hn7gn	<NULL>	The inclusion criteria was voluntary patients users of prostheses, with subclinical findings for Candida in the oral cavity; with no evidence or symptoms of candidosis, but who had a positive result of the presence of the fungus after laboratory culture testing. Therefore, the individuals who do not present evidence or symptoms of oral candidiasis but present Candida was included in the research. Age was not be an exclusion factor for individual over 60 years old, even considering the elderly a vulnerable population, since the health conditions required for this group or any other participant was good general health, i.e. none of the subjects of the research can suffer from decompensated diseases, otherwise they were excluded from the research.	The criteria of exclusion was the presence of dementia; hypertensive patients; patients with heart diseases; transplant patients; patients with kidney diseases or those who used any type of medication to treat oral infections or had used antibiotics during the previous month; patients with intestinal complications, such as lactose or dairy products intolerance; patients presenting evidence and symptoms of oral candidosis, who were treated separately with the traditional antifungals nistatina or miconazole.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7x2f4w	Efficacy of an ice popsicle on thirst management in the immediate postoperative period: a randomized clinical trial	Data analysis completed	Intervention	2016-05-31	<NULL>	<NULL>	878	Ice as strategy to the management of thirst in the immediate postoperative period: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-08	Universidade Estadual de Londrina	Hospital Universitário de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7x2f4w	<NULL>	Aged between 18 and 65 years; undergoing more than eight-hour fasting; expressing thirst spontaneously or stimulated with intensity greater than or equal to three;receiving opioids or anticholinergics in the transoperative period; duration of anesthesia exceeding one hour; having been approved in the assessment of the Safety Protocol for Thirst Management	Patients who had intake or swallowing restrictions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7ms62x	Sugammadex in different weights for motor block antagonism of bariatric surgery - clinical trial	Data analysis completed	Intervention	2016-06-14	<NULL>	<NULL>	889	Sugammadex in ideal weight versus weight for reversal of neuromuscular blockade in surgery for treatment of morbid obesity - double blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-01-25	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7ms62x	<NULL>	Both genders, age between 18 and 65. BMI greater than or equal to 40 kg m -2, only included after signing the written informed consent	known neuromuscular diseases (eg Miastenis Gravis ) Use of drugs that interfere with the transmission neuromuscularAlergia to some of the drugs used in the study renal failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-9qdbh4	Exercises for functionality and balance in elderly	Data analysis completed	Intervention	2016-06-14	<NULL>	<NULL>	891	Multisensory and closed kinetic chain exercises on the functional capacity and balance in elderly women: blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-9qdbh4	<NULL>	women over the age of 60; understand verbal commands ; without orthopedic surgery of the lower limbs and / or history of fracture ; without walking disability ; without the presence of neurological diseases ; without acute inflammation of the musculoskeletal system ; no cancer	Elderly previously undergone orthopedic surgery of the lower limbs ; with walking disability ; in the presence of neurological diseases ; acute inflammation of the musculoskeletal system ; with cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-7r7t52	Effect of creatine supplementation associated with a program of weight training on muscle mass, strength and physical performance in elderly with reduced muscle mass	Data analysis completed	Intervention	2015-03-02	<NULL>	<NULL>	892	Effect of creatine supplementation associated with resistance training on muscle mass, strength and physical performance in Sarcopenic elderly	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-07-04	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7r7t52	<NULL>	Have between 60 and 80 years of age; Be diagnosed with sarcopenia.	Be vegetarian; Take any ergogenic aid in the last 6 months prior to study initiation; Ingest any medication that can affect muscle growth or the ability to train intensely during the study (statins, muscle relaxants, anti-inflammatory); Be involved in restricting food programs; Be involved in physical training programs; Received contrast or performed radioactive procedure last year; Have any kidney disease, liver disease and heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-3zv2py	The answer gymnastics in the water	Data analysis completed	Observational	2016-06-28	<NULL>	<NULL>	901	Effects of physical exercises with weights and acquatic on parameters hemodynamic, vascular, metabolic, strength isometric, body image and quality of life during pregnancy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Escola de Educação Fisica e desportos da UFRJ	Escola de Educação Fisica e desportos da UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-3zv2py	<NULL>	Being over 18 years-old;third  trimester gestational; primiparae;answer negatively to all sentences of the Physical Activity Readiness Questionnaire ;normal blood pressure (140 por 90 mmHg) and  permission by the obstetrician to take part in the study.	Women with body mass index (BMI) over 40 kgm-2; those with some sort of musculoskeletal lesion in the past six months; smokers and those using some kind of supplement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-66xfxh	Yoga exercise for health of the patients with high blood pressure and diabetes	Data analysis completed	Intervention	2016-07-06	<NULL>	<NULL>	910	Yoga exercise for health of the pacients with arterial hypertension and diabetes type II	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-66xfxh	<NULL>	Age between 50 and 75 years; with arterial hypertension light or moderadate; to be under medical and or pharmacological treatment.	Other cardiovascular disease; use of medication bethablockage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-8g42hq	Factors Associated With Abdominal Pain in Patients Submitted to Colonoscopy	Data analysis completed	Observational	2016-07-19	<NULL>	<NULL>	931	Evaluation Factors Associated With Abdominal Pain in Patients Submitted to Colonoscopy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8g42hq	<NULL>	patients of both genders; patients who underwent colonoscopy exam	patients who underwent urgent examination; patients who require deep sedation; patients with incomplete records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-7fpyrp	Assessment of sexual function in low-risk pregnant women	Data analysis completed	Intervention	2016-08-10	<NULL>	<NULL>	951	Evaluation of muscle strength and maternal and perinatal effects of pelvic floor strengthening exercises during pregnancy - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-7fpyrp	<NULL>	Low-risk pregnant women; aged between 18 and 40; literate; capable of getting the MAP checked by vaginal palpation; sexually active (penetrative sex) in the past four weeks, absence of diseases that contraindicate or limit adherence to physical exercise.	Volunteers who have developed diseases that limited exercise;  intolerance physical examination; allergy to condom used in the examination; contraindications of maintaining sexual activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-5h8853	Clinical and Radiographic Evaluations of Restorations in Dentin Surface of Molars Deciduous	Data analysis completed	Intervention	2016-08-10	<NULL>	<NULL>	952	Clinical and Radiographic Evaluation of Minimally Invasive Procedures in Superficial Dentin of Primary Molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-05-10	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5h8853	<NULL>	4 to 9 years of age; with at least one carious lesion involving only the occlusal surfaces of primary molars upper or lower; active lesion; cavitation of at most 2 millimeters (mm) in diameter; radiographically limited if the outer half of dentin;	systemic disease; under 4 years or more than 9; inactive caries lesion; caries lesion involving other surface beyond the occlusal; lesions in the inner half of dentin;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-7994vz	Comparison of presence of microorganisms and measurement of calcium , phosphorus . magnesium, sodium and potassium fresh samples collected from the patient side, at home and after pasteurization	Data analysis completed	Observational	2016-08-11	<NULL>	<NULL>	954	Comparison of microbiological and physicochemical property of raw human milk collected at the bedside , at home and after pasteurization	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7994vz	<NULL>	Mothers of newborn preterm who agreed to participate. No consent was obtained for the use of samples taken from the milk bank , as the same were donated by mothers to the hospital	"Mothers who agreed to sign the free and informed consent .
mothers who had their children over 37 weeks of gestation were excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-4pk67h	Somatic experience as a new technology for the treatment of posttraumatic stress trauma.	Data analysis completed	Intervention	2016-08-16	<NULL>	<NULL>	963	Somatic Experiencing®: Proposing a new technology for the treatment of Stress Disorder Posttraumatic	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Hospital Universitário Lauro Wanderley/UFPB	Grupo de Pesquisa Caleidoscópio da Educação/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-4pk67h	<NULL>	They were accepted federal public servants with links and residence in the city of João Pessoa-PB. With a diagnosis of post-traumatic stress acquired in the workplace. Both genders, ages 18 to 70; referred by psychologists and physicians Subsystem Integrated Server-SIASS Health, who freely agreed to participate in all stages of the study. After informed about the objectives, purposes and study of the amounts accepted they signed the informed consent and informed.	Subjects were excluded if they have 10% lack of SE® sessions at any stage of interventions, had severe psychiatric illness, physical condition that did not allow feel bodily sensations, such as numbness, quadriplegia, hemiplegia; not agreed to participate in the research and / or were not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-7b5hhk	Effects of pumpkin (Cucurbita ficifolia Bouché) in lipid and glycemic profile of type 2 diabetics individuals: a randomized double blinded clinical trial	Data analysis completed	Intervention	2016-08-23	<NULL>	<NULL>	968	In vivo evaluation and monitoring with nanosensors effect hypoglycemic of cucurbita ficifolia Bouché in type 2 diabetic patients	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2012-11-05	Embrapa Hortaliças	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7b5hhk	<NULL>	Individuals diagnosed with pre-diabetes (&gt; 100 to &lt; 125 mg/dL) and individuals diagnosed with type 2 diabetes mellitus (&gt; 126 to &lt; 300 mg/dL).	Individuals diagnosed with Type 2 diabetes for over 6 months with blood glucose &gt; 300 mg/dL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-2dbzdy	Early Neuromuscular Electrical Stimulation in Critically Ill Trauma Patients	Data analysis completed	Intervention	2016-08-23	<NULL>	<NULL>	970	Neuromuscular electrical stimulation in patients with Traumatic Brain Injury under prolonged mechanical ventilation: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade de Brasilia - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Hospital de Base do DF	https://ensaiosclinicos.gov.br/rg/RBR-2dbzdy	<NULL>	Major trauma patients were assessed for eligibility within the first 24 hours after hospital admission. Adults older than 18 years old with invasive mechanical ventilation were included.	pregnancy; stroke; previous neuromuscular disease; suspicion of brain death; lower limb amputation, fracture or skin lesion that restrained ultrasound evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-8rw7dz	Physical exercise and feeding influence over obesity, high pressure, diabetes and high cholesterol in adults and elderly from Santo Antônio de Goiás city.	Data analysis completed	Intervention	2016-09-01	<NULL>	<NULL>	977	Metabolic syndrome: prevalence and effects of physical exercise and nutritional supplementation in adults and elderly of Santo Antônio de Goiás city.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8rw7dz	<NULL>	Women, 20 to 60 years old range, phisically inactive, body mass index higher than 25kg/m2, waist circumference higher than 88cm, any morbidity presench such as hypertension, hyperglycemia or dislipidemias.	Presence of orthopedic limitation, neurological or cardiovascular disease that prevent oriented physical moderate exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-62jk22	Effects of physical exercise and nutrition on the risk of heart disease in adults and elderly in city San Antonio of Goiás	Data analysis completed	Intervention	2016-09-08	<NULL>	<NULL>	986	Metabolic syndrome: prevalence and effects of physical exercise and nutritional supplementation in adults and elderly of city Santo Antonio Goiás	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Universidade Federal de Goiás	Paulo Adriano Naves Prudente	https://ensaiosclinicos.gov.br/rg/RBR-62jk22	<NULL>	Women; age 18-59 years; not be taking regular exercise and targeted to at least one year; have the permission of the medical team for physical exercise; availability time in three days a week in the evening for an hour a day for 6 months; no orthopedic limitations; absence of neurological limitations; absence of severe cardiovascular disease that would prevent the practice of physical exercises.	Unavailability time; history of abuse of alcohol or drugs; We are practicing physical exercise regularly over the past 12 months; not have medical clearance for physical exercise; physical limitations that prevent physical exercise; neurological limitation that prevents physical exercise; cardiovascular disease in serious condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-9hckj4	Study to evaluate safety and possible adverse reactions, especially serious, with a vaccine for measles and rubella in healthy subjects.	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	995	Phase I trial to evaluate safety and immunogenicity of Measles and Rubella vaccine (MR) for measles and rubella, in young adults	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2015-09-18	Bio-Manguinhos/Fiocruz/MS	Bio-Manguinhos/Fiocruz/MS	https://ensaiosclinicos.gov.br/rg/RBR-9hckj4	<NULL>	Healthy volunteers on screening; male; aged between 18-49 years; availability to provide personal data; availability in strictly follow the research protocol; accept not participate in any other clinical trial during this one and up to 6 months after the end; ability to understand and sign the informed consent term; ability to record symptoms at home; acceptance of HIV testing for HIV, HBV and HCV.	Serious adverse event due to the study vaccination; acute or chronic disease; use of allergy shots with antigens, up to 14 days prior to study vaccination; immunoglobulin use in the last 12 months prior to vaccination; use of blood products in the 12 months prior to vaccination; use of any type of vaccine 30 days before vaccination; Chronic use of any medication, except for homeopathic and trivial; previous use of immunosuppressant or cytotoxic medication; use of any investigational medication 1 year prior to vaccination; asthma (unstable, that has required urgent care in the last 24 months, or requiring the use of corticosteroids); neurological, cardiovascular, respiratory, hepatic, renal, hematologic, rheumatic or autoimmune - clinically significant; coagulopathies; Seizures before age 2 years; psychiatric illness that hinder adherence to the protocol; Active malignancy; asplenia; HIV, HCV and / or HBV positive; alcohol abuse (CAGE criteria); illicit drugs abuse; congenital or acquired immunodeficiency; allergy vaccine components, such as egg, neomycin and gelatin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-5k92hq	The evaluation of the use of Alprazolam in third molar surgery	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	997	The evaluation of the use of Alprazolam in outpatient third molar surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-03	Faculdade de Odontologia da Universidade Federal do Pará	Faculdade de Odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5k92hq	<NULL>	The inclusion criteria comprised ASA I patients(according to American Society of Anesthesiology; both genders; ranging from 18 to 45 years old and who needed bilateral maxillary and mandibular third molars extraction	The exclusion criteria comprised presence of systemic changes (ASA III or IV patients); history of hypersensitivity or allergies to benzodiazepines; recent use of benzodiazepines; pregnancy; dependency on narcotic drugs; narrow-angle glaucoma; alcoholism and patients under chronic use of sedatives or analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-83484y	Physical activity and healthy in elderly.	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	998	Resistance and concurrent training with blood flow restriction: hearat rate variability, systemic inflammation effects and neuromuscular adjustments in men and women.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-30	Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas	Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83484y	<NULL>	Volunteers irregularly active or sedentary; both sexes; over 60 years old; non smokers.	Manifestation of ischemic myocardial disease; diabetes; arrhythmias; hypertension; use of medications for the mentioned diseases; joint limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-884bdg	Mobilize response on joint pain and muscle activity in dysfunction temporomandibular: randomized controlled trial study	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	1000	Cranoicervicomandibular system : evaluation methods and multimodal therapeutic intervention	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-884bdg	<NULL>	Women; have TMD diagnosis as the RDC / TMD instrument; Temporomandibular index greater than 0.5 ; belong to age group 18-40 years; patients able to understand commands ; are willing to participate in the study by signing the free and informed consent.	Fracture or previous surgery in orofacial or cervical region; a neurological disorder or neoplastic disease in the craniocervical region; irritable nerve compression evidence assessed by neural tests for the median, radial and ulnar ; They are making use of medications during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-5skmvw	Effect of mobilization of the temporomandibular joint and hyoid bone in the neck system: controlled randomized clinical trial	Data analysis completed	Intervention	2016-09-12	<NULL>	<NULL>	1001	Craniocervicomandibular system : evaluation methods and multimodal therapeutic intervention	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5skmvw	<NULL>	Women; have TMD diagnosis as the RDC / TMD instrument; Temporomandibular index greater than 0.5 ; belong to age group 18-40 years; patients able to understand commands ; are willing to participate in the study by signing the free and informed consent.	Fracture or previous surgery in orofacial or cervical region; a neurological disorder or neoplastic disease in the craniocervical region; irritable nerve compression evidence assessed by neural tests for the median, radial and ulnar ; They are making use of medications during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-2q5yjx	Effectiveness and safety evaluation of biomembrane hemicellulose versus curative collagenase in the treatment of chronic venous ulcers	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1007	Biomembranse of hemicellulose dressing versus collagenase in the treatment of chronic venous ulcers: randomized clinical trial, open and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-08	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-2q5yjx	<NULL>	"Sign the consent form; ge above 18 years; of both sexes; Venous chronic disease with venous chronic ulcer evidenced by one or more of the following signs: Hyperpigmentation of the distal third of the lower limb; stasis eczema; lipodermatosclerosis; varicose veins; One or more ulcers whose minimum evolution time is 6 weeks; present ulcer whose largest size is linear up to 20cm; Ulcers do not occur throughout the circumference of the member
Do not use venotonics drugs; pentoxifylline and fibrinolytic drugs in the last two weeks before the study"	"Having other etiologies ulcers (peripheral arterial disease, causes hematologic, neoplastic, infectious, etc.); Ulcer whose largest linear size is more than 20cm; Ulcers occurring throughout the limb circumference;
Infected ulcer, or when combined with erysipelas, cellulitis or lymphangitis;
Ulcers with critical colonization, or large amounts of exudate and/or foul odor and/or color of the green bed; Necrosis presence in ulcer bed; Venous ulcers associated with peripheral arterial disease that is characterized when the ankle-brachial systolic index (ABI) is less than 0.9 and / or absence of distal pulses, mainly tibioso; History of hypersensitivity to the proposed treatments"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-4zdbbq	Effectiveness of elastic bandage in sedentary women with knee pain.	Data analysis completed	Intervention	2016-09-20	<NULL>	<NULL>	1011	The clinical efficacy of Kinesio Tape for Patellofemoral Pain Syndrome in sedentary women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-4zdbbq	<NULL>	"Female patients , aged between 18 and 43 years;
Clinical diagnosis of PFPS , unilateral or bilateral;
Inactive or irregularly active , according to the criteria of the International Physical Activity Questionnaire ( IPAQ );
History of anterior knee pain for at least 3 months;
Report increased pain in at least two activities related to PFPS , such as up and down stairs , jump , kneel , stand with the knee flexed for long periods or pain palpation of the medial or lateral facet of the patella;
BMI &lt; 29.9 ."	"Osteoarthritis in any degree;
Previous surgery in the lumbar spine , hip, knee , ankle or foot;
BMI&gt; 29.9;
Active or very active, according to the IPAQ criteria;
Patellar or quadriceps tendinopathy;
Patellofemoral instability ( PFI );
Traumatic or atraumatic patellar dislocation;
Ligamentar or meniscal lesion diagnosed clinically or by complementary exams;
Sensitivity to the material used ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6x9gc8	The effects of physical therapy resources in the skin temperature of the abdominal region	Data analysis completed	Intervention	2016-09-22	<NULL>	<NULL>	1012	Thermographic evaluation of abdominal region between different physical therapy dermatofuncionais resources	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	UNIFAL-MG - Universidade Federal de Alfenas-MG	UNIFAL-MG - Universidade Federal de Alfenas-MG	https://ensaiosclinicos.gov.br/rg/RBR-6x9gc8	<NULL>	40 college females; aged between 18 and 30 years; white race; presence of abdominal adiposity observed by the presence of protrusion of abdominal region even when the abdominal contraction with the patient standing; BMI classified as normal (between 18.5 and 25 kg / cm2) as overweight or (25 and 30).	Women in dermatofuncional treatment to reduce localized adiposity; patients with presence of cardiac; respiratory disease; diabetes mellitus; hypertension and cancer; Patients unable to provide a sensitive or changes in skin sensitivity feedback.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-5vrgch	Acupuncture in the Complementary Treatment of Diabetes Mellitus Type II	Data analysis completed	Intervention	2016-09-22	<NULL>	<NULL>	1013	Acupuncture in the Complementary Treatment of Diabetes Mellitus Type II	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Universidade Federal do Rio de Janeiro	Secretaria Municipal de Saúde Vitória / ES	https://ensaiosclinicos.gov.br/rg/RBR-5vrgch	<NULL>	be aged between 30-75 years; Be in possession of Diabetes Mellitus Type II only; Be in drug treatment for at least 1 year properly prescribed (to be confirmed with the medication of revenue); Report difficulties in glycemic control, regular saving measures higher than recommended by the Brazilian Society of Diabetes (postprandial up to 180mg / dl).	have any of the lower limb amputee or part thereof (due to the location of the selected acupoints to the treatment protocol); Be insulin ; Being a smoker;Be alcoholic; Be in drug treatment for other diseases including obesity ; Be making specific diet for weight loss; Practicing regular physical activity; Be in possession of cancer; Being pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-446mrc	Physiotherapy in pubalgy in soccer players	Data analysis completed	Intervention	2016-09-22	<NULL>	<NULL>	1017	Physioterapeutic treatment of pubalgy in a professional soccer player: case study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-04-12	Universidade Vale do Rio Doce	Universidade Vale do Rio Doce	https://ensaiosclinicos.gov.br/rg/RBR-446mrc	<NULL>	Professional soccer player; age between 18 and 22 years old; active in the midfield position; presenting chronic pubalgy symptoms.	Athletes from different sports of football; amateurs Athletes; women; older than 22 years; asymptomatic; athlete who is having physiotherapy treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-4752n8	Effectiveness of topical use of flouride and toothbrushing in the control of white spot carious lesions.	Data analysis completed	Intervention	2016-09-26	<NULL>	<NULL>	1021	Effect evaluation &quot;in vivo&quot; of the fluoride ion and toothbrushing on White spot enamel lesions.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-04-12	UFRN - Universidade Federal Do Rio Grande do Norte	UFRN - Universidade Federal Do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4752n8	<NULL>	Healthy volunteers; between 12 and 18 years old; who needed as part of the orthodontic treatment of extraction of the first two upper premolars and first two lower premolars; they were healthy and without damage to the labial surface; who were not participating in a preventive program involving the use of fluoride.	Volunteers who were not wearing orthodontic braces; Volunteers using fluoridated products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-9y5tbp	Efficiency of bolus insulin therapy versus continuos infusion intravenous insulin in the liver transplant	Data analysis completed	Intervention	2016-09-29	<NULL>	<NULL>	1023	Efficiency of the bolus intravenous insulin therapy versus continuos infusion intravenous therapy in patients submitted to liver transplant	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-9y5tbp	<NULL>	Patient in anesthesia recovery room due to liver transplant; both sex; between 18 and 70 years old; blood glucose at least 180 mg/dl	Patients with severe disfunction after liver transplant; blood glucose values under 150 mg/dl; death at first 48 hours; double transplant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3y357v	Comparison of tracheal tubes for children&apos;s tracheas intubation	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1027	Comparison of the use of uncuffed tracheal tube versus cuffed tracheal tubes filled with saline solution, lidocaine or air in pediatric patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-03	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3y357v	<NULL>	Children undergoing general anesthesia; aged between 3 and 13 years; both genders; physical status 1 or 2 according to American Society of Anesthesiologists; minor or medium level surgery	Oropharyngeal and neck malformations and distortions; patients who had already been intubated or tracheostomised; previous presence of stridor or dysphonia; laryngeal or oropharyngeal illness or surgery; requirement for the introduction of a nasogastric or orogastric tube; more than two attempts at tracheal intubation; use of corticosteroids during the perioperative period; the use of local anaesthetic agents administered through a route other than that used to fill the tracheal tube cuffs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6qr9xx	Effects of supplementation of some nutrients, in elderly, on the inflammation, the muscle, the bone and the body fat	Data analysis completed	Intervention	2016-10-10	<NULL>	<NULL>	1033	Effects of nutritional supplementation on intestine permeability, systemic inflammation and body composition consequences in elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Centro de Saúde Escola Geraldo Horácio de Paula Souza	https://ensaiosclinicos.gov.br/rg/RBR-6qr9xx	<NULL>	Elderly above 60 and below 90 years old; both genders; independent and non-institutionalized; they have to fill at least one of the following criteria of frailty: non-intentional body weight loss in the last six months; exhaustion evaluated by a geriatric depression scale; grip strength below the expected values; gait speed below the expected values; reduced energy expenditure.	Presence of acute or chronic intestinal inflammatory disease; current use of antibiotics; current use of supplements of protein, hormones or other substances driven to enhance muscle mass; current use of synbiotic, probiotic or prebiotic substances; having caner or any inflammatory disease in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7bk8rf	Comparison between strenght training (muscular strenght) and power training (muscular power) in functional capacity in elderly	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1047	Functional capacity of pre-frail elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-05	Centro Universitário do Rio Grande do Norte	Centro Universitário do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7bk8rf	<NULL>	age between 60 and 75 years old; female; have not practiced any kind of regular exercise (2 days per week) within 6 months prior to study entry.	with stage 2 hypertension (systolic 160 mmHg and diastolic 100 mmHg); and present musculoskeletal injury that prevented the completion of the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-776d9s	Influence of an educational manual on the support provided by the companion in the delivery room	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1048	Effects of an educational manual on the support provided by companion during delivery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-776d9s	<NULL>	Accompany pregnant women are undergoing prenatal care in local search, monitor pregnant women who have normal delivery; It has been chosen by pregnant women to attend the birth in the accompanying condition; have up to four years of study	Have previous experience of witnessing the birth in the accompanying condition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7g8p6s	Effectiveness of propolis in reducing the symptoms of rheumatic diseases in humans	Data analysis completed	Intervention	2016-10-19	<NULL>	<NULL>	1049	Propolis effectiveness of therapy in the treatment of signs and symptoms of rheumatism: Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-20	Pós Graduação em Ciências da Saúde	Pós Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7g8p6s	<NULL>	Inclusion criteria were the clinical diagnosis of tendinitis; bursitis or osteoarthritis and presence of pain resulting from rheumatic disease at the time of initial evaluation. Participants did not do any treatment for rheumatism two weeks before the start or during the clinical trial; or intra-articular corticosteroid injections in the previous three months.	We excluded patients with hypersensitivity to bee toxins, obesity, pregnancy and lactation, gastrointestinal bleeding history, gastric perforation; kidney disease, liver disease; current history of alcoholism, use of anticoagulants; implant prosthesis or pacemaker; severe chronic uncontrolled (hypertension, diabetes mellitus, heart disease and other diseases that by its nature or the proposed treatment could interfere with the assessment).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-8m8tmq	Monitoring of Patients with Heart Failure Telephone for Knowledge Improvement and Self Care	Data analysis completed	Intervention	2016-10-24	<NULL>	<NULL>	1056	Impact Telephone Monitoring in the Evaluation of Knowledge and Selfcare of Patients with Heart Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Faculdade de Enfermagem UERJ	Hospital Universitário Pedro Ernesto - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-8m8tmq	<NULL>	Patients with heart failure; who were hospitalized and / or searching the emergence in the last three months due to decompensation by the disease; in clinical follow-up in heart failure clinic of the University Hospital Pedro Ernesto; both sexes; older age or equal to 18 years; not present any functional problem, which prevents him from speaking, writing or interfere with cognition; have telephone contact and availability monitoring.	Heart failure patients in very advanced stage with no prospect of life (greater than or equal to 6 months); and / or with other comorbidities in terminal stage that might interfere with evaluation; Stage IV according to the functional classification of the New York Heart Association.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-9jth8n	Effect of passion fruit&apos;s peel flour in the diabetes control	Data analysis completed	Intervention	2016-09-19	<NULL>	<NULL>	1075	The effect of passion fruit&apos;s peel flour in glycemic control of people with type diabetes	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-02-18	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Universidade da Integração Internacional da Lusofonia Afro Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-9jth8n	<NULL>	"Being person with type 2 diabetes; between 18 and 65 years old; both sex; no problems in liver or kidney; Not be allergic to passion
fruit."	Being patient with type 1 diabetes; smoker; alcohol drinker; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-29s6x3	Physical exercise for hemodialysis patients	Data analysis completed	Intervention	2016-11-29	<NULL>	<NULL>	1079	Physical exercise for hemodialysis patients: randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-15	Universidade Federal do triângulo mineiro	Universidade Federal do triângulo mineiro	https://ensaiosclinicos.gov.br/rg/RBR-29s6x3	<NULL>	Aged 18 to 65, hemodialysis for a minimum period of three months; not use anti-inflammatory; to be able to physical exercise and sedentary for a period longer than or equal to 3 months.	The presence of intense physical fatigue; chest pain; dizziness; pallor; syncope; tachycardia; hypotension; lower limb fatigue; weight gain interdialytic greater than 5 kilograms; difficult vascular access or any significant complaints of pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-4twh4m	Impact of toothbrushing in the prevention of pneumonia in Intensive Care Unit - ICU	Data analysis completed	Intervention	2016-12-05	<NULL>	<NULL>	1085	Impact of oral hygiene in the prevention of ventilator-associated pneumonia in Intensive Care Unit: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-07-01	Universidade Federal de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4twh4m	<NULL>	Individuals with age equal or greater than 18 years; submitted to endotracheal intubation; expected to remain on mechanical ventilation for &gt;48 hours; without evidence of pulmonary infection at Intensive Care Unit admission.	Individuals without teeth; suspicion of pneumonia at the time of endotracheal intubation; pregnancy; tracheostomy; chlorhexidine allergy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-2pxh57	Evaluation of eyes implanted with corneal inlays for correction of presbyopia	Data analysis completed	Intervention	2016-12-06	<NULL>	<NULL>	1090	Evaluation of Presbia for the treatment of presbyopia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-05-01	Universidade Federal de Sao Paulo	PresbiBio	https://ensaiosclinicos.gov.br/rg/RBR-2pxh57	<NULL>	Age between 45 years and 60 years, both gender, uncorrect near visual acuity (UNVA) worse than J4, uncorrect distance visual acuity (UDVA) better than 20/40, corrected near visual acuity (CNVA) and correted disttanve visua acuity(CDVA) better than 20/20, spherical equivalent (SE) refraction for distance ranging between 0.25 diopter (D) and 1.00 D, up to 0,75 D of astigmatism, full-time reading glasses for near visual tasks required for a minimum of 1 year, clearly determined ocular dominance, central corneal thickness (CCT) greater than 500 micra, mesopic pupilary diameter more than 3mm and endothelial cell count 2000 cells/mm2 in the eye to be implanted	Anterior and posterior segment pathology, including cataracts in the eye to be implanted, previous intraocular or corneal surgery including cataract and LASIK surgery, chronic systemic or topical corticosteroids, or other immunosuppressive therapy that may affect wound healing, and any immuno-compromised subjects, systemic medications with significant ocular side effects and subjects who use telescopes or microscopes for professional reasons, or have high vision requirements or expectations like surgeons, architects, accountants, professional athletes or pilots.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-4x92fr	Evaluation of serum Vitamin D levels in patients with Polycystic kidney disease.	Data analysis completed	Intervention	2016-12-08	<NULL>	<NULL>	1096	Serum vitamin D levels in Autosomal Dominant Polycystic Kidney Disease (ADPKD)patients.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-08	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4x92fr	<NULL>	Volunteeers with Autosomal Dominant Polycystic Kidney Disease; both genders; aged between 18 to 75 years; normo or hypertensives; vitamin D deficient [25(OH) &lt; 30ng/ml).	Age &lt; 18 years old; serum calcium &gt; 10 mg/dL; serum phosphorous &gt; 5,5 mg/dL; pregnancy; bowel disease; malignances; current/past use of vitamin D or calcium supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-2s9xvn	Study of methotrexate for the control of chronic inflammation in sickle cell disease patients	Data analysis completed	Intervention	2016-12-19	<NULL>	<NULL>	1103	Pilot study of targeted-therapy with methotrexate for the control of chronic inflammation in sickle cell disease patients	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2014-12-01	Centro Infantil Boldrini	Centro Infantil Boldrini	https://ensaiosclinicos.gov.br/rg/RBR-2s9xvn	<NULL>	Patients with sickle cell disease who are under chronic hydroxyurea treatment, have more than 3 vaso-occlusive crises per year, and who experience a current vaso-occlusive crisis that is refractory to opioids for a period longer than 3 weeks. Patients should be older than 18 years. Patients must have signed the Informed Consent Form.	Pregnancy. Ongoing infection at recruitment into the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-249t3r	Pilates effects in pregnant women	Data analysis completed	Intervention	2016-12-20	<NULL>	<NULL>	1106	Effects of Physical therapy through Pilates on the health of pregnant women and newborns	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-13	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-249t3r	<NULL>	Were considered as inclusion criteria:  gilts; aged over 18 years ; the absence of gestational complications described by the medical follow-up.	Exclusion criteria will be considered: multiple pregnancy; presence of chronic low back pain and / or urinary incontinence prior; inability to perform physical exercises by the presence of neurological or musculoskeletal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-89cp93	Effectiveness of dental care for prevention of nosocomial respiratory tract infections among intensive care patients.	Data analysis completed	Intervention	2016-12-22	<NULL>	<NULL>	1110	Effectiveness of dental care for prevention of nosocomial respiratory tract infections among intensive care patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89cp93	<NULL>	Patients of both sexes, aged between 18 and 100 years old, admitted to the ICU of the study, if they had a expected time of hospitalization exceeding 48 hours.	Pregnancy, blood dyscrasia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-5x8ttb	Caffeine supplementation can make runners run further and improve pace strategy	Data analysis completed	Intervention	2016-12-27	<NULL>	<NULL>	1121	Effects of creatine and caffeine supplementation association in street runners performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-21	Erico Chagas Caperuto	Elias de França	https://ensaiosclinicos.gov.br/rg/RBR-5x8ttb	<NULL>	Healthy participants which did not use any ergogenic supplements in the last 6 months preceding the test.	Individuals without previous experience in running on the treadmill; intolerant individuals to caffeine use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-9gghtb	Costs and benefits of papachia in pediatric dentistry: A randomized clinical trial	Data analysis completed	Intervention	2017-01-08	<NULL>	<NULL>	1135	Cost evaluation and comparison of the public health benefits of the atraumatic method of caries removal with papayar gel in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-10	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade de Cruz Alta	https://ensaiosclinicos.gov.br/rg/RBR-9gghtb	<NULL>	Children of both sexes, enrolled in the 1 year of Municipal Schools of the city of Ijuí of RS state that had carious lesions cavitated in deciduous or permanent molars	Children who did not have restorative needs, or had only dental caries lesions, or that the parents or guardians did not accept to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-799724	Women with Temporomandibular dysfunction pain are more responsive to nadolol analgesic effect	Data analysis completed	Intervention	2017-01-10	<NULL>	<NULL>	1142	Effect of nadolol on Temporomandibular pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	Fapesp - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-799724	<NULL>	Men and women (using or not oral contraceptive), aged between 18 and 48 years and met Research Diagnostic Criteria for TMD (RDC/TMD) class I (muscle pain) and II (articular pain).	"Self-reported osteoarthroses (RDC group IIIc), rheumatoid arthritis, fibromyalgia, trigeminal neuralgia, gynecological disorders (endometriosis), asthma, chronic lung disease, bronchospasm, renal, hepatic or cardiovascular diseases, nasal polyps, angioedema, reactivity to acetylsalicylic acid or other NSAIDs. Irregular menstrual cycles, use of hormonal replacement therapy, pregnancy or nursing, craniofacial trauma or surgery within the last 6 weeks, orthodontic treatment, and depression or other psychiatric conditions, seizures, drug abuse, current chemotherapy or radiation therapy; patients taking the following medications: drugs with central nervous system action (e.g., opioids, benzodiazepines, nonbenzodiazepine sedative hypnotics, selective serotonin reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, and anticonvulsants) and ?-blockers. Medications for headaches (e.g.  triptans) and NSAIDs were not allowed during the last two days before the study visits. 
Subjects with low heart rate (e.g. under 55 bpm) and diastolic blood pressure below 50 mmHg were excluded from the study to reduce the risk of an adverse hypotensive response to ?-blockade."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-8k5yzn	Facial pain treatment in individuals with Fibromyalgia: effect of laser therapy versus anesthetic infiltration.	Data analysis completed	Intervention	2017-01-11	<NULL>	<NULL>	1143	Orofacial pain treatment in individuals with Fibromyalgia: Effect of laser therapy versus anesthetic infiltration of trigger points	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-25	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8k5yzn	<NULL>	Patients with fibromyalgia according to the American College of Rheumatology criteria; aged between 18 and 76 years; sufficient autonomy and cognitive levels to understand procedures and follow instructions without help of another person; report of orofacial pain in the last 3 months.	Patients who did not voluntarily participate in this research; allergic to lidocaine; or who have changed their systemic medications in the last 3 months treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-37tjbg	Analysis of the electrical activity of muscles used in gait of paraplegic patients in two different gait training methods using a support of body weight	Data analysis completed	Observational	2017-01-11	<NULL>	<NULL>	1144	Electromyographic analysis of muscles used in gait of patients with spinal cord injury in two different training modalities with body weight suspension	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Fernanda Cechetti	https://ensaiosclinicos.gov.br/rg/RBR-37tjbg	<NULL>	Patients who agree to participate in the study and sign the Informed Consent Term (TCLE), with clinical diagnosis of spinal cord injury, ASIA C or D score, ie, incomplete injury with motor preservation below the neurological level, with Most of the key muscles below that level with less than or equal to three muscle strength, respectively, and are able to remain seated independently in a bed.	Patients who present with weight-bearing contraindications, such as a fracture of the hip or lower limb, or because they have bedsores. Also, patients who present with unstable angina or other decompensated heart disease, chronic obstructive pulmonary disease, neurological diseases such as Parkinson&apos;s or stroke or have a symptomatic drop in blood pressure when upright.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-56dkrb	knowledge and attitude of women from the Brazilian state of Rio Grande do Sul regarding discovery of breast cancer	Data analysis completed	Intervention	2017-01-13	<NULL>	<NULL>	1150	knowledge and attitude of women from the Brazilian state of Rio Grande do Sul regarding early detection of breast cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-56dkrb	<NULL>	Women over 18 and under 80 years of age;with cognitvas able to perform the reading of educational material ; with conditions to respond to the study questions	Illiterate women; who did not have a position to answer the questions raised by the research, based on age , level of consciousness or difficulty of communication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-6rp2sn	The Importance of Hand Therapy download package in the use of the affected arm out of therapy.	Data analysis completed	Intervention	2017-01-16	<NULL>	<NULL>	1151	The relevance of the Therapy Transfer Package for containment induced in the upper limb of use out of the therapeutic environment.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Hospital e centro de reabilitação da AACD	Hospital e centro de reabilitação da AACD	https://ensaiosclinicos.gov.br/rg/RBR-6rp2sn	<NULL>	Diagnostic Chronic stroke (above 6 months of injury); Asymmetry in the functional use of the upper limbs; Rated motor activities as grade 2 or 3, according to the degrees engines TCI table; Cognition suitable for simple commands and numerical scores.	Having performed the TCP protocol previously; Pain that interferes with activities in therapy and at home; More than two consecutive faults; Having performed peripheral chemical lock before three months of the beginning of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-7yjwpf	Evaluation of the relationship between salt intake and blood pressure in different amounts of salt consumed	Data analysis completed	Intervention	2017-01-17	<NULL>	<NULL>	1159	A double-blind, randomized clinical trial to evaluate the dose-response relationship between salt intake and blood pressure at different levels of salt intake	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-20	Universidade Federal de Goiás	Liga de Hipertensão Arterial do Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7yjwpf	<NULL>	Workers of Campus I of the Federal University of Goiás; Age between 20 and 60 years; Of both sexes.	Blood pressure greater than 160mmHg of systolic and 100mmHg of diastolic independent of the use of hypotensors; Use of more than two antihypertensive drugs or secondary hypertension; Type I and II diabetics; History of atherosclerotic disease; Need for special diet for any reason whether religious, dietary control or syndromes; Do not carry out at least 4 main meals per week, prepared at home, whether lunch or dinner.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-3qd5gf	Quality of life of diabetics and hypertensives from a basic health unit in Guarapuava / PR	Data analysis completed	Observational	2017-01-26	<NULL>	<NULL>	1169	Quality of life of the users of the Hiperdia group of the unit basic health: Recanto Feliz in Guarapuava / PR.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Franciele Aparecida Amaral	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-3qd5gf	<NULL>	Users of the basic health unit with systemic arterial hypertension and / or diabetes mellitus of both sexes enrolled in the SisHiperdia program under follow-up by the primary health unit team, users aged over 18 years, individuals who are aware of the research development and who Accepted the conditions established in the work and specified in the term of free and informed consent	Individuals with temporary residence in the neighborhood where the basic health unit is located, travelers from other neighborhoods, illiterates, children and users unable to respond to the questionnaire due to cognitive, neurological problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-2s7j59	Effect of telephone follow-up to improve self-efficacy, duration and exclusivity of breastfeeding	Data analysis completed	Intervention	2017-01-26	<NULL>	<NULL>	1171	Effects of a telephone educational intervention on the self-efficacy, duration and exclusivity of breastfeeding: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2s7j59	<NULL>	Women in the immediate puerperium; With at least six hours postpartum; With single, full-term gestation; With newborns hospitalized in the joint housing; Who are carrying out the practice of Breastfeeding; Have at least one telephone contact.	Puerperas that had been contraindicated to breastfeeding; With mental restrictions that made it impossible to understand the instrument; With children hospitalized in the intensive care unit; Whose children were born with disabilities that impede breastfeeding; Hearing impaired.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-95tt75	Presence of bone, joint and muscle pains in farmers who grow tobacco in the city of Prudentópolis-PR	Data analysis completed	Observational	2017-01-27	<NULL>	<NULL>	1173	Incidence of musculoskeletal pain in smokers in the city of Prudentópolis-PR	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Faculdade Guairacá (Centro Coordenador)	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-95tt75	<NULL>	Tobacco-producing farmers; male; age from 20 to 45 years; agree to participate in the research and sign the informed consent form.	Hearing deficiency; physical disability; cognitive changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-9d8xr6	Benefits of aquatic physiotherapy in the health of the elderly	Data analysis completed	Intervention	2017-01-30	<NULL>	<NULL>	1174	Contribution of aquatic physiotherapy in the health of the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-29	Franciele Aparecida Amaral	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-9d8xr6	<NULL>	Elderly people aged 60 to 80 years; Of both genders; Who frequent the HIPERDIA group; That present independent gait and independence in activities of daily living (ADLs). Individuals should be aware of the research and that they accept the conditions established in the work and specified in the Informed Consent Term (ICT).	Elderly without dermatological medical certificate favorable to aquatic physiotherapy; Urinary or fecal incontinence; Presence of open wounds, probes, tracheostomies, infectious cutaneous diseases, neurological diseases, infectious diseases, renal insufficiency, heart disease without cardiologist&apos;s authorization, severe pneumopathies, uncontrolled hypertension or above 160 X100 mmhg, vascular thrombi, Severe cognitive and auditory deficits, severe osteomioarticular pathologies, physical deficiency; Participation in other physical activities or even Aquatic Physiotherapy less than 6 months or that are in another type of moderate physical activity supervised with two or more times in the week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-57s29p	The benefits of dance in quality of life and depression in the elderly from  Boa Ventura de São Roque-PR	Data analysis completed	Observational	2017-01-30	<NULL>	<NULL>	1175	Quality of life and depression in a group of seniors from Boa Ventura de São Roque-PR	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Franciele Aparecida Amaral	Faculdade Guairacá (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-57s29p	<NULL>	60 to 85 years; both sexes.	Severe cognitive impairment; orthopedic or neurological changes that moderately affect functional capacity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-82qf9m	Occurrence of sensitivity evaluation with and without sonic activation of a desensitizing gel before in office bleaching in adults	Data analysis completed	Intervention	2017-03-03	<NULL>	<NULL>	1176	Sensitivity absolute risk evaluation with and without sonic activation of a desensitizing gel previously to in office bleaching in adults	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2016-01-20	Verônica Pereira de Lima Bertocco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-82qf9m	<NULL>	Patients aged 18 years and over, upper teeth free of caries and the anterior superior free of restorations in the vestibular face, besides central incisors or canines presenting A2 or darker coloration, evaluated in comparison with a visual scale of color guided by the value Of teeth (Vita Classical, Vita-Zahnfabrik- Germany).	Pregnant or lactating women, smokers, users of fixed orthodontic appliances, individuals with severe intrinsic stains on the teeth (spots on the use of tetracycline, fluorosis and depolluted teeth), users of antiinflammatory and antioxidant drugs and participants with a previous history of tooth sensitivity or any Associated pathology (bruxism, gingival recession, non-carious lesion with dentin exposure).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-4mkg73	Lifestyle intervention in pregnant women.	Data analysis completed	Intervention	2017-03-07	<NULL>	<NULL>	1180	Impact of an intervention for promotion leisure-time walking and healthy eating among pregnant women in antenatal care.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Faculdade de Medicina, Universidade Estadual Paulista Julho de Mesquita Filho, Botucatu-SP	Faculdade de Saúde Pública, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mkg73	<NULL>	pregnant women enrolled in the antenatal low-risk public health system in the urban area of Botucatu-SP; aged equal to or greater than 18 years old; being in the first trimester.	prenatal care in private health services; change city; Suffer abortion; Have high obstetric risk (pre-eclampsia,gestational diabetes).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-2pr7zp	Effects of unmetabolized folic acid on DNA modifications, messenger RNA expression and in the function of blood NK cells in individuals who consume folic acid in fortified flours or as a vitamin supplement.	Data analysis completed	Intervention	2017-03-27	<NULL>	<NULL>	1192	Effects of unmetabolized folic acid on global DNA methylation, mRNA expression and NK cells citotoxicity in individuals exposed to mandatory fortification with folic acid and/or therapeutic use of this vitamin	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2pr7zp	<NULL>	Healthy subjects; both sexes; aged between 18 and 45 years.	Individuals under 18 years, chronic alcoholics; patients with acute or chronic diseases; pregnant women; users of immunosuppressive medications, vitamins or vitamin supplements; blood donors in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-2ffv9g	Evaluation of respiratory physiotherapy in infants with Tachypnea	Data analysis completed	Intervention	2017-03-24	<NULL>	<NULL>	1196	"Evaluation method thoraco-abdominal 
In newborn  with transient tachypnea diagnostic"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-22	Universidade Federal Fluminense	Fundação Educacional Serra dos Órgãos - FESO	https://ensaiosclinicos.gov.br/rg/RBR-2ffv9g	<NULL>	"We included in the study, Newborn with diagnosis of Transient tachypnea of the newborn admitted to the Neonatal Intermediate Unit.
Gender both sexes."	Newborn with tachypnea, whose etiology was related to Central Nervous System (CNS) alterations, cardiac alterations or malformations, hematological alterations or the presence of any congenital malformation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-92b9dg	Hemolysis and inflammatory response to extracorporeal circulation during on-pump coronary artery bypass graft surgery: comparison between roller and centrifugal pump systems	Data analysis completed	Intervention	2017-03-30	<NULL>	<NULL>	1200	Comparative analysis of the incidence of hemolysis and systemic inflammatory response induced by extracorporeal circulation in the roller pump and in the centrifugal pump in the perioperative period of myocardial revascularization	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-14	Hospital das Clínicas da Faculdade de Medicina de Botucatu (FMB) da Universidade Estadual Paulista (Unesp)	Universidade Estadual Paulista-Unesp, Faculdade de Medicina de Botucatu.	https://ensaiosclinicos.gov.br/rg/RBR-92b9dg	<NULL>	Adult patients with coronary artery disease with surgical indication for myocardial revascularization with extracorporeal circulation, aged between 30 and 80 years of age, with and without associated diseases, with people of both sexes.	Adult patients requiring other cardiovascular surgeries (valve, congenital, aortic), coronary artery bypass grafting with associated carotid artery surgery; Anemia prior to surgery; Inflammatory or infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-26qt3h	Brief intervention in group performed by nurses in the hazardous alcohol use	Data analysis completed	Intervention	2017-03-31	<NULL>	<NULL>	1201	Effectiveness of brief intervention in group performed by nurses in the hazardous alcohol use	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-11-15	Escola de Enfermagem Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-26qt3h	<NULL>	People older than 18 years; with availability to attend the group for the time and given time; who could read and write; available to receive follow-up.	People with visible behavioral changes; intoxicated; not available to participate in the proposed intervention;  who refused to receive the follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-2g89x8	Pregabalin to improve the quality of anesthesia care in bariatric surgery	Data analysis completed	Intervention	2017-04-18	<NULL>	<NULL>	1216	Pregabalin to improve the quality of anesthesia care in bariatric surgery : a randomized clinical trial , triple blind , placebo controlled	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Unesp	Hospital Teresa De Lisieux	https://ensaiosclinicos.gov.br/rg/RBR-2g89x8	<NULL>	Patients undergoing open bariatric surgery;Age: 18 to 64anos;Sex  female and male;ASA : P1 ; P2 ; P3	History of allergy to pregabalin; Kidney disease; liver disease; Angle-closure glaucoma diagnosis; History of epilepsy; Patients using monoamine oxidase inhibitors or who have stopped use in the last 14 days.Patients illiterate; unable to sign the consent form. Chronic use of opioids and antidepressants;Allergy to NSAIDS and dipyrone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-8z74d2	Training of arms on body alignment individuals with cerebral palsy: a pilot study	Data analysis completed	Intervention	2017-05-15	<NULL>	<NULL>	1234	Impact of upper limb training on body alignment in gait of children and adolescents with spastic hemiparesis-type cerebral palsy: pilot project	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-27	Associação de assistencia a criança deficiente	Associação de assistencia a criança deficiente	https://ensaiosclinicos.gov.br/rg/RBR-8z74d2	<NULL>	"Individuals of both sexes;
Aged between 07-15 years of age;
PC spastic hemiparesis type;
Who were not performing Physiotherapy, Occupational therapy or Physiotherapy aquatic;
They were able to obey simple commands;"	"Clinical instability;
Have undergone some type of orthopedic surgery and neuromuscular blockade for less than six and three months respectively."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-5n9g5f	The Vencer Saúde project: study protocol for healthy weight loss with nutritional and exercise training monitoring	Data analysis completed	Intervention	2017-05-17	<NULL>	<NULL>	1235	Healthy weight loss program: nutrition monitoring and physical activity for overweight people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-09	Universidade Federal de Sergipe - UFS	Fundação de Apoio à Pesquisa e Inovação Tecnológica de Sergipe - FAPITEC/SE	https://ensaiosclinicos.gov.br/rg/RBR-5n9g5f	<NULL>	Age between 18 and 59 years; Body mass index of 25 kg/m² to 39.9 kg/m²; weight stable in the last three months; sedentary.	use of drugs for weight loss; eating disorders; osteoarticular diseases; diabetes mellitus; hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-54vnnf	Educational game about breastfeeding for school children of primary school	Data analysis completed	Intervention	2017-05-19	<NULL>	<NULL>	1240	Educational technology about breastfeeding for school children of primary school	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-54vnnf	<NULL>	Children regularly enrolled in the third year of elementary school; attending school during the school calendar in the data collection period; in the age group from seven years; both genders; able to develop activities that include reading words and phrases; understand the guidelines for the development of activities explained by others.	Children who were separated due to illness or those with special needs, identified by the class teacher, that made it difficult to understand questions of the questionnaire and the information of the game, making it impossible to participate in the educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-8y56jt	The use of peripherally inserted central catheter mono e double lumen in neonatal intensive care unit	Data analysis completed	Intervention	2017-05-23	<NULL>	<NULL>	1243	Randomized trial on the use of peripherally inserted central catheter (PICC_ mono and double lumen in neonatal intensive care unit (ICU)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-13	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8y56jt	<NULL>	Need of parenteral total nutrition; need of venous catheter for more than six days; use of antibiotics or vasoativ drugs and consent by parents	Use or duration of the PICC for less than 7 days; Use of another central catheter prior to inclusion in the survey; Initial location of the catheter tip in the peripheral region; Transfer of the Intensive Care Unit (ICU) during the period of use of the PICC and parents under the age of 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-5ckpd3	Effect of pelvic physiotherapy in women with pain during sexual intercourse	Data analysis completed	Intervention	2017-05-26	<NULL>	<NULL>	1248	Effect of pelvic floor muscle training on the sexual function of women with symptoms of dyspareunia: An experimental study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5ckpd3	<NULL>	Sexually active women who had clinical symptoms of dyspareunia	Those who underwent physiotherapeutic intervention for dyspareunia symptoms recently (less than 6 months); Current symptoms of urinary tract infection; And the presence of diseases that constitute contraindications for the accomplishment of the MAP training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-4tf6mr	Cellular application analysis on communication: improvements for teaching in nursing	Data analysis completed	Intervention	2017-06-02	<NULL>	<NULL>	1250	Analysis of a learning object about therapeutic communication: contribution to teaching in nursing	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-22	Universidade Estadual do Ceará - Programa de Pós Graduação em Cuidados Clínicos em Enfermagem e Saúde	Faculdade Metropolitana da Grande Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4tf6mr	<NULL>	The student must be attending the discipline of psychological bases for the first time in the undergraduate nursing course and possessing a smartphone.	Students under the age of 18 and those who did not have basic computer skills and use of technology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7rw2qq	Comparison of two types of protocols for the construction of dentures	Data analysis completed	Intervention	2017-06-09	<NULL>	<NULL>	1252	Comparison of different methods for making conventional complete dentures	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Odontologia da Universidade Federal de Goias	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7rw2qq	<NULL>	Fully edentulous, with need of new upper and lower conventional complete dentures	"Patients unable to cooperate;
Patients in poor general health or conditions that could influence their response to treatment such as temporomandibular disorders, orofacial motor disorders, severe oral manifestations of systematic disease or psychological or psychiatric condition"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-8swgc3	Inspiratory Mucle Training in Patients after Cardiac Surgery.	Data analysis completed	Intervention	2017-06-13	<NULL>	<NULL>	1256	Inspiratory Muscle Training in Patients Undergoing Cardiac Surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-05	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8swgc3	<NULL>	Patients undergoing cardiac surgery; Both genes; Age between 18 and 80.	"Evolved Death in the peri-operative period;
Evolved With pulmonary complications Or neurological factors that impeded the avaliation; They needed prolonged mechanical ventilation (&gt; 24 hours); They needed Non-invasive mechanical ventilation for more than 4 hours per day."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-4y8vd2	Acupuncture as another treatment option for women who have Pain in the belly foot and Muscle Pain in the belly that did not improve with the Injection of Anesthetic at the pain site	Data analysis completed	Intervention	2017-06-19	<NULL>	<NULL>	1258	Acupuncture as an alternative method for the treatment of women with Chronic Pelvic Pain and Myofascial Syndrome not-responsive to Topical Injectable Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-11	Faculdade de Medicina de Ribeirão Preto / Universidade de São Paulo - FMRP/USP	Faculdade de Medicina de Ribeirão Preto / Universidade de São Paulo - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-4y8vd2	<NULL>	Women with diagnostic criteria for chronic pelvic pain secondary to abdominal myofascial syndrome; Presence of only one active trigger point on the abdominal wall, have not undergone previous treatment with topical injectable block or acupuncture, age above 18 years and premenopausal, visual analogue scale with a value above 4.4 (moderate pain)	Women with anticoagulation or hemorrhagic disorders, local or systemic infections; Allergy to anesthetics, acute muscle trauma, extreme fear of needles; History of complaints of chronic musculoskeletal pain such as fibromyalgia, chronic fatigue or diabetes; Aspirin intake within 3 days after injection; All patients with suspected endometriosis, interstitial cystitis, irritable bowel syndrome, or other disease that warrants or contributes to chronic pelvic pain; Endometrioma or hernia evidenced by ultrasound of the abdominal wall, infections of the abdominal wall, lack after the beginning of the treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-7s6khg	Preoperative physiotherapy for radical prostatectomy	Data analysis completed	Intervention	2017-06-27	<NULL>	<NULL>	1270	Evaluation of the preoperative Pelvic Physiotherapy in the Urinary Continence of patients submitted to radical retropubic Prostatectomy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Santa Casa de Misericórdia de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7s6khg	<NULL>	Patients between 40 and 75 years; Diagnosis of prostate cancer; eligible to radical retropubic prostatectomy at Santa Casa de Porto Alegre; Informed consent; Participate in the initial assessment and willingness to perform two sessions of preoperative pelvic physiotherapy.	Patients with previous pelvic radiotherapy; neurological diseases; previous prostatic transurethral resection; Urinary incontinence; Erectile dysfunction and inability to do pelvic exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-8qhcys	The influence of robot-assisted gait training on stroke survivors with ataxia	Data analysis completed	Intervention	2017-07-05	<NULL>	<NULL>	1278	The influence of robot-assisted gait training on Stroke survivors with ataxia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-23	UNIFESP- Universidade Federal do Estado de São Paulo	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-8qhcys	<NULL>	"Stroke survivors with ataxia. Minimum time of injury over 1 year. Clinical stability. Presence of hemiplegia or quadriplegia motor impairment.
Both genders and who were at least 18 years of age were accepted and 80 years maximum. A physician examined all the patients and described their diagnosis in medical records."	"Physical disability that made training with the robotic device unsafe such as cognitive impairment. Dementia. Aphasia. Presence of other orthopedic or neurosurgical problems in the lower extremities. Pressure ulcers on the hips or lower extremities. Weight higher than 120 kg.
Ataxia originated by progressive disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-96xzyf	Unilateral Hearing Loss: benefit of the use of the hearing aid in the abilities of sound localization and ordering and temporal resolution	Data analysis completed	Intervention	2017-07-06	<NULL>	<NULL>	1281	Unilateral hearing loss: benefit of amplification in the ordering and temporal resolution and sound localization	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade de São Paulo	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-96xzyf	<NULL>	Volunteers from 18 to 60 years; both genders; with unilateral sensorineural or mixed acquired hearing loss; no experience with individual sound amplification apparatus; with indication of the device complying with the SAS / MS 587 Directive.	Neurological alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8wfjw9	The effect of flat and textured insoles on the balance of community elderly people	Data analysis completed	Intervention	2017-05-09	<NULL>	<NULL>	1282	Effect of textured and flat insoles on the balance of community elderly people: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-07	Faculdade de Ciências Médicas	Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-8wfjw9	<NULL>	"Elderly aged 65 or older
Able to read and answer the proposed questionnaires"	Reduced Tactile or Thermal sensitivity; lower limbs&apos; cutaneous integrity compromitted; Vestibular disease;Patologies evolving Central Nervous System disorders: Parkinson, Strokes and Diagnosed concomitant dementias; Lower limbs Neuropathies; Use of insoles less than 30 days before the research; Previous Feet surgery; Lower limbs amputation;use of benzodiazepines or tricyclic antidepressants Impossibility to attend the necessary reassessments; Inability to follow directions and collaborate with study protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-9fxqs2	Effects on the muscles after the use of the vaginal dilator in pregnant	Data analysis completed	Intervention	2017-07-10	<NULL>	<NULL>	1286	Muscle responses after the physiotherapeutic intervention with the use of the vaginal dilator in pregnant women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9fxqs2	<NULL>	"Age between 18 and 35 years;
Gestational age of 34 weeks;
Primparas;
Physiological gestation;
With medical authorization to perform the physiotherapeutic intervention."	"Multiple gestation;
Presence of high gestational risk;
Presence of bone deformities;
Presence of important muscular dysfunctions;
Unusual fetal position or risks that make vaginal delivery impossible (placenta previa);
Presence of risk of ascending infection such as vaginal infection (such as premature amniorrhexis, vaginal infection);
Presence of unhealed lesions in the vaginal region;
Be visibly under the influence of drugs or alcohol;
Presence of vaginal bleeding;
Presence of cervical cancer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-5td5hg	Influence of Bleaching Gel storage temperature on Color stability and Dental Sensitivity	Data analysis completed	Intervention	2017-07-17	<NULL>	<NULL>	1293	Influence of Bleaching Gel storage temperature on Color stability and Dental Sensitivity	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	CESCAGE - Centro de Ensino Superior dos Campos Gerais	CESCAGE - Centro de Ensino Superior dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5td5hg	<NULL>	Healthy volunteers; Both genders; Age between 18 and 40 years, with upper and lower anterior teeth with vitality; Adequate oral hygiene; With central incisors that should be A2 or darker in color according to the Vita scale (VITA classical, VITA Zahnfabrik, Bad Säckingen, Germany)	Voluntary smokers; Pregnant and lactating women; Patients with teeth showing staining caused by tetracycline; Fluorosis; Hyperplasia; endodontic treatment; Presence of restorations in the eight upper and lower anterior teeth; Previous dental sensitivity; Parafunctional habits; Cervical lesions (abrasion, erosion and abfraction), periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-3br7jc	Massage and Aromatherapy for treatment of Low back Pain and Quality of life improvement	Data analysis completed	Intervention	2017-07-19	<NULL>	<NULL>	1299	Applicability of Complementary Practices to reduce Pain, Stress, Anxiety and improvement of Quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-3br7jc	<NULL>	Pain greater than or equal to 5 in the Visual Analogue Scale; nonspecific low back pain for more than 3 months; age between 20 and 55 years; both genders	Spondylolisthesis; disc herniation; use of anti-inflammatories or analgesics; open areas such as wounds or burns; skin cancer; severe infections; extensive edema;pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-9tkt8z	Auriculoterapia e Massagem for Neck Pain and  Quality of life improvement	Data analysis completed	Intervention	2017-07-24	<NULL>	<NULL>	1304	Applicability of the Auriculotherapy and Massage to reduce Pain, Stress, Anxiety and Quality of life improvement	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-9tkt8z	<NULL>	Pain score equal or greater than 5 by the Visual Analogue Scale; age between 20 and 55 years	"Paresthesia; decreased strength; anti-inflammatory drugs; analgesics and muscle relaxants; cervical spine surgeries;
inflammation and or infection in treated regions;tissue damage in the external ear or cervical and thoracic region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3pw3hd	Strength training for elderly women	Data analysis completed	Intervention	2017-07-24	<NULL>	<NULL>	1305	Effect of a Strength-Training Program with Self-Selected and Prescribed Intensity on Adherence, Psychophysiological Responses, Functional Capacity, Quality of Life and Body Composition in Sedentary Elderly Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-01	Universidade Federal do Paraná - UFPR	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-3pw3hd	<NULL>	Woman; age between 60 and 70 years; body mass index between 18.5 and 30 kg/m2; insufficiently active	Signs and symptoms of cardiovascular, respiratory, metabolic or renal diseases; severe musculoskeletal problems that limit the practice of physical activity; not presenting medical authorization; positive response in any item in the Physical Activity Readiness Questionnaire (PAR-Q); ex-smoker or smoking status	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-6th7rt	Clinical evaluation of different delivery methods of At-home bleaching with 10% Hydrogen Peroxide	Data analysis completed	Intervention	2017-07-26	<NULL>	<NULL>	1310	Sensitivity and Genotoxicity assessment in adolescents submitted to Bleaching with Strips or Trays	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UFAM - Universidade Federal do Amazonas	UFAM - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6th7rt	<NULL>	Volunteers had between 15 and 20 years; at least one central incisor or canine with A2 or darker color; six upper anterior teeth restorations-free on the buccal surface.	Volunteers with systemic diseases (metabolic, immunological and cardiopathies); periodontal disease; enamel showing changes; volunteers with braces; severe crowding; presence of intrinsic stains; use of anti-inflammatory drugs; smoking; drinking; in pregnancy or lactation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-4cmxry	Effects of Osteopathic and strength exercise in Resistance, Muscular Strength and Speed Blood  of Cardiac Patients.	Data analysis completed	Intervention	2017-08-02	<NULL>	<NULL>	1315	Effects of Treatment Osteopathic Manipulative (TMO) and resistance exercise circuit (REC) in cardiorespiratory capacity, Muscular Performance and Blood Flow of Patients with Heart Failure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-17	Pós-graduação em Ciências e Tecnologias em Saúde da Faculdade de Ceilândia - UNB	Pós-graduação em Ciências e Tecnologias em Saúde da Faculdade de Ceilândia - UNB	https://ensaiosclinicos.gov.br/rg/RBR-4cmxry	<NULL>	Diagnosis of heart failure documented in the last 6 months; left ventricular systolic dysfunction &lt;35 % demonstrated by echocardiography; New York Heart Association classification ( NYHA ) class II and III and without participation in aerobic or resistance training programs in the last three months before the study protocol.	Individual previously diagnosed with moderate or severe chronic obstructive pulmonary disease; recent heart surgery in the last 3 months); morbid obesity; peripheral vascular disease and person who is not able to perform the exercise protocol resisted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-72mvj5	Effects of Alternative Foods on Muscular and Fat Mass of children	Data analysis completed	Intervention	2017-08-08	<NULL>	<NULL>	1324	Nutritional effects of Protein-Energy Fortification of school meals for children in situation of Food Insecurity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-72mvj5	<NULL>	Children aged 6 to 11 enrolled in the 1st, 2nd or 3rd years of elementary school of a public school in the city of Santa Maria - RS - Brazil, and who responded positively to the invitation (written and spoken) to participate in the study; children whose parents or guardians voluntarily signed the Informed Consent Term.	Children with a history of chronic-degenerative diseases (diabetes, liver or kidney disease); children with  edema; children with soy allergy; children who attended classes less than 80% of the days used for intervention in phase II of the study; children who missed any of the nutritional assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-2q53ct	Self-care Education: A Comparative Study of the Quality of Life of Patients With Head and Neck Cancer	Data analysis completed	Intervention	2017-08-08	<NULL>	<NULL>	1327	Education for Self-management: A Comparative Study of the Quality of Life of Patients With Head and Neck Neoplasia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Escola Paulista de Enfermagem - Universidade Federal de São Paulo	Escola Paulista de Enfermagem - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2q53ct	<NULL>	Patients with head and neck neoplasia; Submitted to the first oncological treatment; Both sexes; older than 18 years; Less than 80 years.	Patients with previous oncological treatment, patients diagnosed with psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-36cw3y	Strength Training for patients with Parkinson&apos;s Disease identified by a biochemical examination	Data analysis completed	Intervention	2017-08-08	<NULL>	<NULL>	1328	Resistance Training Program for patients with Parkinson&apos;s Disease diagnosed by molecular analysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-36cw3y	<NULL>	Volunteers diagnosed with Parkinson&apos;s disease by a neurologist specializing in movement disorder; both genders; age greater than or equal to 60 years; stage 1-3 on the Hoehn and Yahr scale; and stable use of medication.	Severe cognitive impairment (Mini-Mental State Exam score &lt;24); inability to walk independently; neurological, cardiopulmonary or orthopedic diseases; have participated in some exercise protocol prior to this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-7gr6js	Effects of video game therapy in the management of gait in chronic post-stroke individuals	Data analysis completed	Intervention	2017-08-02	<NULL>	<NULL>	1329	Effects of virtual reality therapy in the treatment of gait in chronic hemiparetic individuals after ischemic stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-09	Universidade de Araraquara (UNIARA)	Universidade de Araraquara (UNIARA)	https://ensaiosclinicos.gov.br/rg/RBR-7gr6js	<NULL>	Inclusion criteria were the occurrence of stroke episode (single, unilateral, ischemic) at least 6 months before the beginning of the study, minimum score in the Mental State Mini Exam according to the volunteer&apos;s level of education and in the item &quot; &quot;(2 points) of the Admissional Scale. In addition, maintenance of standing posture was necessary without support or use of a walking aid for one minute according to item 2 of the Berg scale.	Exclusion criteria for a presence of cardiovascular diseases; cognitive or communication deficiencies that preclude a procedure exercise; antecedents of joint or muscular injuries in the lower limbs (fractures, dislocations or surgery and generalized ligament laxity).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3fqb7f	The impact of information on the corrected age in the development of premature baby and parents everyday	Data analysis completed	Intervention	2017-08-25	<NULL>	<NULL>	1346	The impact of Corrected Age information on the development of Preterm Infants and their parents&apos; Daily Lives	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-12	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3fqb7f	<NULL>	Infants enrolled in the Neonatal Intensive Care Unit Preventive Care Program; Corrected age less than two 24 months; First consultation; Signature of the Consent Form and clarified by one of the parents or guardian	Infants with osteomyelitis; Neonatal neurological disorders; Diagnosed in social vulnerability; Parent mental issues	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-4gs6s3	Seed treatment under stress analysis in women who work more than 30 hours a week	Data analysis completed	Intervention	2017-08-28	<NULL>	<NULL>	1348	Auriculotherapy for stress management in women who work more than 30 hours a week	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-02	Universidade Paulista-Campus São José do Rio Pardo	Universidade Paulista-Campus São José do Rio Pardo	https://ensaiosclinicos.gov.br/rg/RBR-4gs6s3	<NULL>	Women; Individuals who present with stress symptoms; Working hours greater than 30 hours per week; Do not use drugs that will inhibit the autonomic nervous system.	Pregnant women; Use of medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-37n859	New hospitalizations and correct Heart Failure treatment of patients with Heart Failure after hospital discharge orientation and telephone contact	Data analysis completed	Intervention	2017-08-28	<NULL>	<NULL>	1350	Rehospitalization and treatment adherence of patients with Heart Failure after hospital discharge orientation and telephone contact	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Instituto Dante Pazzanese de Cardiologia- SP	Instituto Dante Pazzanese de Cardiologia- SP	https://ensaiosclinicos.gov.br/rg/RBR-37n859	<NULL>	"&gt; 18 years old;
telephone number avaiable for after discharge;
admitted with heart failure in emergency;"	"&lt; 18 years old;
cardiac surgeryc in the last 3 months;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-2kch38	Effects of Stomach Reduction Surgery on oral health	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	1353	Repercussions of Bariatric Surgery on oral health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-20	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-2kch38	<NULL>	Obese volunteers of both genders; aged between 16 and 60 years; with indication for stomach reduction surgery; who underwent bariatric surgery in the year 2015 and 2016.	Edentulous individuals; with physical limitations; with mental limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-45v5sw	Evaluation of the impact of the Living with Style and Health Program on prevention and control of Diabetes and Hypertension	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	1357	"Living with Style and Health Program:
pilot study of an educational approach for the prevention and control of Diabetes and Hypertension"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-15	Universidade Paulista - UNIP	Universidade Paulista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-45v5sw	<NULL>	Volunteers over 18 years of age; Both genders; With or without diagnoses of diabetes or hypertension.	Volunteers under the age of 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-33t6zm	Physical Exercise To Improve Cerebral Circulation In Kidney Disease	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	1359	Influence Of Intradialytic Aerobic Training On Cerebral Blood Flow And The Reflex On Cognitive Function And Quality Of Life In Chronic Renal Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade Estadual Paulista - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-33t6zm	<NULL>	Patients with Chronic Kidney Disease in hemodialysis treatment for a period of more than or equal to 3 months; stable medication; no contraindications for performing physical activity	Inability to understand the procedures performed; previous diagnosis of coronary artery disease; previous positive exercise test for cardiac ischemia; patient classified as active or very active based on the instrument applied; patient suffering from stroke; carrier of neoplasia; infection Acute or chronic in activity; HA Stage II; previous diagnosis of dementia; delirium; presence of depression;use of drugs that influence cognitive function	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4bxrfy	Hiking effects on quality of life during Chemotherapy treatment of Breast Cancer	Data analysis completed	Intervention	2017-09-04	<NULL>	<NULL>	1362	Quality of life in women submitted to Chemotherapy on post-operative Breast Cancer: hiking effects on Myelosuppression and Muscle Fatigue	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Instituto Radium de Campinas Ltda (filial São João da Boa Vista)	Rebeca Garcia Rosa Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-4bxrfy	<NULL>	Women on adjuvant chemotherapy; who were in the second, third or fourth cycle of chemotherapy; and who performed the cycle of Doxorubicin and Cyclophosphamide use.	Women who have had radiation therapy or hormone therapy; who performed the cycle of use Placlitaxel or FEC (Fluorouracil, Epirubicin and Cyclophosphamide); who had high cardiac risk on the echocardiogram; above 75 years of age; unable to respond to questionnaires; with distant metastasis; and unable to walk.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-2tbjpk	The challenges of providing dental care to adults with Down syndrome	Data analysis completed	Intervention	2017-09-04	<NULL>	<NULL>	1363	Conscious sedation technique with oral midazolam for dental treatment in adult patients with Down&apos;s Syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-09	School of Dentistry Universidad de Buenos Aires	School of Dentistry Universidad de Buenos Aires	https://ensaiosclinicos.gov.br/rg/RBR-2tbjpk	<NULL>	"All patients with Down syndrome; older than 18 years; negative behavior for dental care;, 
 controlled Hypertension; controlled hypothyroidism; controlled diabetes"	All patients with Down syndrome, who showed no change in behavior and were receptive to dental treatment; Down syndrome patients who were uncontrolled hypertension; type 1 diabetes; respiratory failure; asthma and renal failure; patients can be treated by the dentist after receiving counseling; all patients with medical contraindications for the use of midazolam.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4zx26w	Measurement of thigh muscle strength in patients with knee arthrosis who will receive a lubricating injection to the knee and who will do bodybuilding	Data analysis completed	Intervention	2017-09-04	<NULL>	<NULL>	1365	Evaluation of knee extension and bend strength in patients with knee arthrosis who will receive and will not receive an injection in the knees of HILANO GF-20 and who will do bodybuilding	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-07	Hospital Universitario Clementino Fraga Filho	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-4zx26w	<NULL>	Sedentary women or that had spent at least a minimal period of six months without any kind of exercising;clinic and radiological diagnosis of gonarthrosis level II and III; pain complaint equal to or higher than 6 according to the Visual Analog Scale.	Non-collaborative patients; who were illiterate or who answered less than 85% of the questions due to difficulty in understanding, presenting with comorbidities that interfered with the performance or the execution of the exercises or that presented cardiovascular risk to the practice of the exercise, fracture sequelae, large joint angular deformity, joint blockage; ankyloses that were eligible for any surgical procedure or that had already undergone any surgical treatment in the knees; had any hypersensitivity related to poultry proteins in their clinical history.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-5bt6kd	The effect of Platelet-rich Plasma and Corticosteroids in treatment of shoulder Tendinitis	Data analysis completed	Intervention	2017-09-05	<NULL>	<NULL>	1369	Comparative study of Platelet-rich Plasma and Corticosteroids in treatment of Rotator Cuff Tendinopathy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-05-31	Universidade Tiradentes	Universidade Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-5bt6kd	<NULL>	age between 18 and 70 years old; positive Neer test; no previous treatment of IV corticosteroids, injectable or oral in the last 12 months; hemoglobin greater than 11g/dl; platelet count greater than 150000/mm³; and signature of the informed consent form.	association with adhesive capsulitis; complete rupture of the rotator cuff in ultrasonography; loss of follow-up and use of oral or parenteral corticosteroids during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-6mgqn3	The use of Aromatherapy associated with Massagem on Stress from a nursing staff at the surgical center	Data analysis completed	Intervention	2017-09-11	<NULL>	<NULL>	1371	Aromatherapy with Massage on Stress from a nursing staff at the surgical center	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Departamento de Enfermagem da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6mgqn3	<NULL>	Healthy volunteers; both genders; age between 18 and 60 years; to be working regularly in the sector (surgical center); to consent participate in the research by signing the Free and Informed Consent Form; achieve a minimum score of 12 points on Vasconcelos Stress Symptom List; olfactory acceptance of the odor of lavender (Lavandula angustifolia) and geranium (Pelargonium graveolens) essential oils; and declare not being pregnant.	Loss of follow-up of aromatherapy massage sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-7nkxkf	Strength and Balance training improve functional capacity in institutionalized Elderly	Data analysis completed	Intervention	2017-09-11	<NULL>	<NULL>	1372	The influence of Strength Training, Endurance and Balance in institutionalized Elderly: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Centro Universitário Metodista Ipa	Centro Universitário Metodista Ipa	https://ensaiosclinicos.gov.br/rg/RBR-7nkxkf	<NULL>	To have functional independence through the Barthel index; Be over 65 years of age; Cognition above 30 points in the mini mental state examination, any gender	against absolute and relative indications for the six-minute walk test; limiting orthopedic disorders; fracture in the last six months; indication or previous surgery column; Bracing dependence for locomotion as a wheelchair; walker; Crutches; Flares; uncontrolled hypertension ; indication or thoracic surgery in the last six months; dependence on oxygen therapy and cognitive , auditory or visual changes to limit the understanding of assessments and interventions .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-9n35t4	Early Mobility Protocol to neurological inpatients	Data analysis completed	Intervention	2017-09-15	<NULL>	<NULL>	1375	Developing an Early Mobility Protocol to neurological patients in the wards of hucff	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho - HUCFF	https://ensaiosclinicos.gov.br/rg/RBR-9n35t4	<NULL>	systolic blood pressure between 90 and 160 mmHg, heart rate between 40 and 130 beats per minute (bpm), respiratory rate between 10 and 40 breaths per minute, peripheral oxygen saturation &gt;90%	Mecanical Ventilation in Controlled Mode; Need for Vasopressors; Recent Myocardial infarction; Acute Fracture in Lower Limbs; Fracture with instability of spine; Platelets &lt; 20 000; Hematocrit &lt; 25%; Hemoglobin &lt; 7 g/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-56q7h9	The Effect of Grape Seed and Grapefruit Seed Extracts on Bone Regeneration: randomized clinical trial	Data analysis completed	Intervention	2017-09-18	<NULL>	<NULL>	1379	Effect of Natural Compounds on Bone Regeneration: a human study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-28	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-56q7h9	<NULL>	adult male patients, non-restorable tooth and installation of oral implants; need for implant-supported crown	History of chemotherapy or radiotherapy of the head and neck; previous periodontal disease; alcohol abuse; history of bisphosphonate therapy; diabetic patients who were decompensated; smokers; any contraindication to oral surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-6gt3rt	Facilitated Tucking during Peripheral Venipuncture in hospitalized preterm infants	Data analysis completed	Intervention	2017-09-18	<NULL>	<NULL>	1380	The use of Facilitated Tucking Peripheral Venous Puncture in hospitalized neonates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-06	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6gt3rt	<NULL>	Premature newborns with gestational age 32-36 weeks and 6 days; Newborn requiring venous blood;	Neonates with neurologic, cardiac and gastrointestinal malformations; Neonates using medicines that interfere with hemodynamic parameters (Dobutamine, Dopamine, Fentanyl, Midazolam, Diazepam, Caffeine Citrate, Aminophylline, Chloral Hydrate and Ranitidine); Peripheral venipuncture in the cephalic region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-7kss24	Impact of capoeira lessons on cognition of children from 06 to 12 years	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1382	Impact of capoeira lessons in the executive functions of children from 06 to 12 years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio Grande do Norte (UFRN)	https://ensaiosclinicos.gov.br/rg/RBR-7kss24	<NULL>	healthy children; both genders; from 8 to 12 years; literate.	children with learning disorder; attention deficit hyperactivity disorder; intellectual disability; hearing impaired: visual impairment without correction; who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-5jx29r	Evaluation of restorations performed with two glass ionomer cements on temporary teeth.	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1383	Randomized clinical trial of two high viscosity´s restorative Glass Ionomer Cements used in deciduous molars.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Metropolitana de Santos (UNIMES)	Universidade Metropolitana de Santos (UNIMES)	https://ensaiosclinicos.gov.br/rg/RBR-5jx29r	<NULL>	Healthy child from 05 to 08 years old, without systemic alteration; good behavior; Presenting clinically at least two deciduous molars with dentin caries lesion involving only the occlusal, with direct vision and access, without clinical and radiographic signs and symptoms of pulp involvement.	Child with systemic impairment. Non-contributory behavior. Black, Class II, III or IV type carious lesion. Clinically: carious lesion involving enamel, deficient restorations, small carious lesions in dentin (no access for hand excavators), occult caries lesions, sign and / or clinical symptom of pulp involvement, clinical impossibility of restoration. Radiographically: evidence of pulp involvement, carious lesion extending beyond 2/3 of the dentin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9hyh9w	Individual guidelines for changing the attitude of breastfeeding in mothers with newborns hospitalized	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1388	Breastfeeding: impact of a program of guidance individuals on the attitude of breastfeeding of puerperae with newborns hospitalized in an intermediate care unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-9hyh9w	<NULL>	Postpartum women who agreed to participate in the study, by signing the Informed Consent Form; Puerperas with newborns hospitalized immediately after delivery at the research unit with gestational age greater than thirty-four weeks; Birth weight greater than one thousand five hundred grams; Absence of changes that prevent breastfeeding.	Multiple gestation; Newborn with diagnosis or suspicion of congenital heart diseases, syndromes or congenital malformations; Genitoras requiring hospitalization in an intensive care unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-53bmfx	Effectiveness of Acupuncture as treatment on Headache	Data analysis completed	Intervention	2017-09-19	<NULL>	<NULL>	1389	Effectiveness of Acupuncture as auxiliary treatment on Chronic Headache	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-53bmfx	<NULL>	Patients between 18 and 60 years old were included in the study; female; with chronic headache using medication prescribed by the Pain Specialist; who had never undergone acupuncture treatment.	Patients with decompensated and/or severe arterial hypertension; those who were diagnosed with secondary headache and were under treatment with physical therapy or other non-drug auxiliary treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9trcpn	Pilates in the posture and balance of the elderly	Data analysis completed	Intervention	2017-09-21	<NULL>	<NULL>	1394	Analysis of the effect of the pilates method on the postural profile and balance of the elderly community in the neighborhood of Pedro in Teresina - PI	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Associação Teresinense de Ensino	Associação Teresinense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-9trcpn	<NULL>	Age of 60 to 80; female; be resident of the São Pedro neighborhood in Teresina Piauí; be a participant in the extension group Roses of the Evening of the Faculty of St Augustine; absence of osteoarticular disease; not practice physical activity	Spondylolisthesis; spondylolisthesis; bone tuberculosis; huge discrepancies of the lower limbs; metallic prostheses of the knee and hip; presence of labyrinth disorders; participants who did not agree with the research objectives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-27fvry	To verify the influence of moderate or strenuous Physical Activity and Sedentary lifestyle on the rate of Urinary Incontinence in young women who had never had children	Data analysis completed	Intervention	2017-09-21	<NULL>	<NULL>	1400	Influence of Physical Activity levels and Sedentary behavior in the prevalence of Urinary Incontinence in young nuliparous women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade do estado de Santa Catarina/UDESC	Faculdade de Engenharia da Univerasidade do Porto (FEUP)	https://ensaiosclinicos.gov.br/rg/RBR-27fvry	<NULL>	Be female; aging between 18 and 40 years; nulliparous; sedentary behaviour (did not practice regular physical activity); and had urinary incontinence and / or sexual dysfunction.	Women with a history of diabetes mellitus; chronic pelvic pain; previous pregnancy; and history of gynecological surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-6pvvdb	Physical exercises decrease stress in nurses	Data analysis completed	Intervention	2017-09-28	<NULL>	<NULL>	1406	Exercise and Stress	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Faculdade de Ciências Médicas da Universidade do Estado do Rio de Janeiro	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-6pvvdb	<NULL>	Men and women professionals of Nursing of the State Institute of the Brain Paulo Niemeyer; age between 18 and 60 years.	Clinical impediments to exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9qg3bg	Effects of water aerobics on body measurements, fat percentage, quality of life, postural balance and daily activities in the elderly	Data analysis completed	Intervention	2017-09-28	<NULL>	<NULL>	1407	Influence of a Balance development program on elderly community residents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal Fluminense	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9qg3bg	<NULL>	Non-participants of any regular physical activity program in the six months prior to the survey.	Elderly people with disabilities that impair the body balance, as blindness or uncorrected visual impairment, and/or hearing impairment. Parkinson&apos;s, Alzheimer&apos;s or dementia diagnosed by a doctor. Lower limb prostheses. Against medical indication for exercising. Cognitive impairment detected by the Mini Mental (score below 24).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-443bqc	The influence of music on pain and physiological responses in sedated patients.	Data analysis completed	Intervention	2017-10-02	<NULL>	<NULL>	1411	The influence of music therapy on pain and physiological responses in patients of an Adult Intensive Care Unit of the Federal District.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Escola Superior de Ciências da Saúde	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-443bqc	<NULL>	Patients of both genders; Age above 18 years; With continuous sedation; In use of mechanical ventilation by means of an orotracheal tube; With stable hemodynamics; Preserved auditory acuity.	Patients in blood transfusion; during dialysis; in use of vasoactive drugs; in use of a mattress or thermal blanket; if sedation was switched off; extubated; death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-2vrqrn	Effectiveness of Automatic Brushes in Down Syndrome Patients	Data analysis completed	Intervention	2017-10-04	<NULL>	<NULL>	1413	Brush effectiveness compared to manual brush without dental biofilm control with down syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-03	Universidade Federal do Piauí	Secretaria de Educação do Estado do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2vrqrn	<NULL>	Individuals with medical diagnosis of Down Syndrome; In the age group from 4 to 14 years of age; Linked to the local study center; Have in the dental arch 1 tooth or more in each sextant.	Individuals with systemic alterations or psychological condition that make participation in the study impracticable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9qpn2b	Effectiveness Mobilization with movement and Tape of Mulligan in ankle Functional Unstable: a randomized study	Data analysis completed	Intervention	2017-10-17	<NULL>	<NULL>	1425	Effectiveness MWM e Tape of  Mulligan in ankles Functional Unstable: a randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Salgado de Oliveira	Universidade Nacional de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-9qpn2b	<NULL>	"Informed Consent Term.
Both sexes.
Age between 18-50 years.
History of ankle sprain injury.
Score below 17 on the CAIT questionnaire.
Body mass less than 25%."	"Disabling pain in any joint of the lower limb including the ankle.
They had already undergone surgery on the lower limb.
History of lower limb fracture.
That they were allergic to the components of the different types of bandage.
Any other contraindication to physical exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-4gzbqn	Effect of the Hydrotherapy physical function and quality of life in older people with Chronic Diseases	Data analysis completed	Intervention	2017-10-17	<NULL>	<NULL>	1426	Effectiveness of the Aquatic Physiotherapy program in functional fitness and quality of life in older people with Non-Transmissible Chronic Diseases	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-4gzbqn	<NULL>	Elderly volunteers in the age group between 60 and 80 years old; with hypertension; diabetes; osteoarthritis; with good adaptation to the liquid environment.	Volunteers who present cardiorespiratory; musculoskeletal; neuromuscular dysfunctions that prevent the aquatic intervention program and contraindications of aquatic physiotherapy; such as otitis; hydrophobia; urinary infections and skin lesions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-7cnj5g	Association between Aerobic Capacity and Sleep in Elderly	Data analysis completed	Intervention	2016-06-16	<NULL>	<NULL>	1431	Association between Cardiorespiratory fitness and Sleep in Elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal da Paraíba	Pulmonar Diagnóstico	https://ensaiosclinicos.gov.br/rg/RBR-7cnj5g	<NULL>	Aged 60 years or older; Men and women; body mass index (BMI) between 18.5 and 29.9 kg / m²; Diagnosed with hypertension; No use of beta-blockers; Considered irregularly active (IPAQ adapted for the elderly).	Smokers / recent ex-smokers (&lt;6 months); Diabetes mellitus; restrictive respiratory diseases / obstructive and / or cardiovascular	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-88kqmx	Use of two different Desensitizing Gels to avoid Sensitivity to Tooth Whitening	Data analysis completed	Intervention	2017-10-19	<NULL>	<NULL>	1433	Use of different Desensitizing Gels on Sensitivity to Cleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-10	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-88kqmx	<NULL>	patients aged 18 years and older; of both sexes; at least six upper anterior teeth free of caries and restorations on the vestibular face; at least one central or canine incisor showing coloration A2 or darker, evaluated in comparison to a visual value-oriented color scale of the teeth.	users of fixed orthodontic appliances; patients with periodontal disease; pregnant or lactating women; severe intrinsic stains on the teeth (spots on the use of tetracycline, fluorosis and depolluted teeth); consuming any Anti-inflammatory and antioxidant drugs; using desensitizing dentifrice and participants with previous history of SD or any associated pathology (bruxism, gingival recession; non-carious lesion with dentin exposure).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-8gzwzp	The evaluation of the nurse performed at the home of children and adolescents with Severe Asthma.	Data analysis completed	Intervention	2017-10-23	<NULL>	<NULL>	1434	Nursing Home Visit in the treatment of children and adolescents with Severe Asthma	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-08	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8gzwzp	<NULL>	To be patients of the Multidisciplinary Center for Patients with Asthma of Difficult Control; be between 3 and 18 years of age; be residents of Belo Horizonte or metropolitan region.	Residing outside Belo Horizonte and metropolitan áreas; having other pathologies such as cystic fibrosis; ciliary dyskinesia; tuberculosis; bronchiolitis obliterans post infectious; interstitial pneumopathies, congenital pulmonary and bronchial tree malformations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-243gf6	Effect of a controlled release system of doxycycline for control of periodontal disease	Data analysis completed	Intervention	2017-10-23	<NULL>	<NULL>	1437	Effect of a controlled release system of doxycycline for control of periodontal disease: randomized double masking clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2014-02-02	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-243gf6	<NULL>	Individuals presenting chronic periodontitis (AAP-1999); individuals with contralateral quadrants containing at least one molar with presence of sites with probing depth 5 mm, clinical insertion level 6 mm and bleeding at probing; over 18 years.	Presence of periapical and pulpal alterations; presence of gingivitis and acute periodontal conditions (abscesses and acute necrotizing periodontitis); presence of candidosis and changes in the mucosa; allergy to the components of gels and periodontal dressings; presence of systemic diseases (cardiovascular, blood dyscrasias, immunodeficiencies, transplanted, diabetes, osteoporosis, nephropathies, hepatopathies); need for antibiotic prophylaxis before periodontal treatment; use of systemic antibiotics, chemotherapeutics of controlled or continuous use and others that may interfere with the inflammatory process or have adverse effects directly in the periodontium in the last 6 months; pregnancy and contraceptive users during the study and during the previous three months or lactation; smokers; surgical or non-surgical periodontal treatment in the last 6 months; treatment with chlorhexidine mouthwash 0.12% or other topical chemical agent in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-2t56nz	The Effect of L-arginine in the treatment of Sickle Cell Anemia	Data analysis completed	Intervention	2017-10-24	<NULL>	<NULL>	1439	Double Blind Randomized Trial for L-arginine Effectineness study as a coadjuvante therapeutic protocol in the treatment of Sickle Cell Anemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2t56nz	<NULL>	Adult patients volunteers between 18 and 80 years with sickle cell anemia; both genders; in use of hydroxiurea from 500mg per day; baseline	Patients who do not have sickle cell anemia; Patients who refuse to participate in the study not signing the ethic term; those who have had transfusional therapy in the last three months; patients using iron chelator and antioxidant vitamins; patients smokers and drinkers; pregnant or with diabetes mellitus or with some picture of renal or hepatic insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-6n3mw9	The Teaching of Nursing by Realistic Simulation for Palliative Care	Data analysis completed	Intervention	2017-10-26	<NULL>	<NULL>	1445	Use of Realistic Simulation for the teaching of palliative care in nursing: a randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6n3mw9	<NULL>	Nursing students volunteers; Regularly enrolled in the fourth, fifth, sixth and seventh periods of the institution&apos;s nursing course; Both genders and over 18 years of age.	Nursing course students who are absent; Licensed in the period of data collection; With irregularity in the enrollment and under 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-8xvwpj	Impact of seats with different ergonomic designs on postural changes, low back pain and cervical pain in dental academics	Data analysis completed	Intervention	2017-10-26	<NULL>	<NULL>	1446	Impact of seats with different ergonomic designs on postural changes, low back pain and cervicalgia in dental academics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Faculdade de Odontologia de Piracicaba- Unicamp	Fundação Hermínio Ometto - Uniararas	https://ensaiosclinicos.gov.br/rg/RBR-8xvwpj	<NULL>	Healthy volunteers; both genders; age between 18 and 50 years; enrolled in disciplines with clinical care of patients.	Volunteers who made continuous use of pain medication; with diagnosis of mental disorders; in clinical and / or physiological conditions that made it impossible to perform the clinical care of patients;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-9h3c2b	Hypotension post-Aquatic Exercise	Data analysis completed	Intervention	2017-10-23	<NULL>	<NULL>	1449	Influence of an Aquatic Exercise session on Hemodynamic Responses of Hypertensive elderly subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-02	Institutos Paraibanos de Educação	Institutos Paraibanos de Educação	https://ensaiosclinicos.gov.br/rg/RBR-9h3c2b	<NULL>	Elderly; both genders; physically active; hypertension.	Obesity; Diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-3yqqgv	The use of intravenous morphine to treat the pain of children undergoing adenoid and tonsil removal surgeries	Data analysis completed	Intervention	2017-09-29	<NULL>	<NULL>	1452	Use of intravenous morphine for postoperative analgesia in children submitted to adenotonsillectomy surgeries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3yqqgv	<NULL>	Exclusive surgeries of tonsillectomies, associated or not with adenoidectomies; age between 3 and 10 years; weight between age-related Z 2 and + 2 scores and considered adequate; physical condition with absence of comorbidities or pathological processes other than those related to the process responsible for the surgery (upper airway infection and / or obstruction); absence of chronic diseases or any deficiencies; schedule the child&apos;s hospital admission on the morning of the day of surgery, since they were planned for 7:30 am; ability of the child to respond to the visual scale of postoperative pain assessment.	Children who were not accompanied by parents or caregivers in the postoperative period; patients in whom there was no follow-up of the standardized anesthetic technique in the study; tonsillectomy performed by warm techniques, such as electrocautery and coblation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-2335ks	Comparative study between a phytotherapeutic and chlorhexidine on alveolar healing	Data analysis completed	Intervention	2017-10-31	<NULL>	<NULL>	1455	Comparative Study of the Elixir Sanativo and Chlorhexidine on Alveolar Healing	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-07	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2335ks	<NULL>	systematically healthy patients; indication for contralateral tooth extraction from extensive carious lesion, periodontal disease or orthodontic indication, without osteotomy or odontosection	uncontrolled systemic pathologies; smokers; alcoholics; pregnant women; patients allergic to one or more drugs used; patients who have used anti-inflammatory drugs or antibiotics in the last 7 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4f32xy	Team-Based Learning: comparing learning methods in nursing	Data analysis completed	Intervention	2017-06-01	<NULL>	<NULL>	1461	Team-Based Learning: A randomized clinical trial in undergraduate nursing and the construction of educational technology.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-16	Departamento de enfermagem da Unesp	Unesp ( Universidade Estadual Paulista)	https://ensaiosclinicos.gov.br/rg/RBR-4f32xy	<NULL>	The students of the 3rd year of undergraduate nursing; will be included in the study, enrolled in the average 27 students in the discipline of Nursing in Surgical Center, who agree to participate in the study.	Students who are not in class at the time of data collection will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-8qdf7t	Effect of topical Dipyrone application in tooth sensitivity caused from In Office Dental Bleaching	Data analysis completed	Intervention	2016-01-29	<NULL>	<NULL>	1464	Effect of the use of topical Dipyrone in tooth sensitivity resulting from In Office Dental Bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-27	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-8qdf7t	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening, pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology. Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems; diabetes; hypertension or are making continual use of drugs with analgesic and anti-inflammatory or who have allergies to Dipyrone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-9z764g	OM-85BV for prevention of respiratory tract infections	Data analysis completed	Intervention	2017-11-01	<NULL>	<NULL>	1465	OM-85BV for prevention of respiratory tract infections: a double-blind, placebo-controlled, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-9z764g	<NULL>	Both female and male children 1 to 5 years old; daycare or preschool attendance; written informed consent signed and dated by a parent or legal guardian in accordance with the ethical standards of the local ethics research committee.	Children diagnosed with asthma, cystic fibrosis, major systemic condition, immune disorders, suspected malabsorption, known allergy to bacterial extracts, major surgery within 3 months of study entry, recent immunosuppressive, immunostimulant or corticosteroid therapy or any other chronic disease that might affect the results; premature babies (less 36 weeks gestation); children participating in other research studies during this project; children who have received OM-85 or any other immunostimulatory or immunosuppressive agents including cyclosporine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-59xfk3	Evaluation of the effects of dark chocolate with 70% cocoa on cardiovascular health in patients with heart failure	Data analysis completed	Intervention	2017-11-07	<NULL>	<NULL>	1469	Evaluation of the effects of dark chocolate with 70% cocoa on hemodynamic and endothelial parameteres in patients with heart failure	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Programa de Pós Graduação em Ciências Cardiovasculares	Clínica de Insuficiência Cardíaca Coração Valente	https://ensaiosclinicos.gov.br/rg/RBR-59xfk3	<NULL>	Sedentary men or women between the ages of 40 and 80;Body mass index (BMI) above 18.5 kg / m 2 for both sexes;Stage 1, 2 and 3 ICC according to the NYHA classification criteria, (1994)	"In use of any dietary supplement you have in your formulation Antioxidant nutrient and chocolate;Creatinine clearance less than 60 mL / min; Smokers or former smokers (less than two years of Smoking);Liver and / or pancreatic disease;Unstable angina pectoris;
Allergy to chocolate or its derivatives;Patients with stage 4 heart failure according to the criterion of NYHA classification (1994); Physical examination with presence of edema;Presence of infectious, autoimmune or immunosuppressive disease; Presence of cardiac cachexia;Presence of hypoalbuminemia;Use of pacemaker;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-7mbrp3	Pharmacists’ knowledge about dispensing of drugs after completing a training course	Data analysis completed	Intervention	2015-04-13	<NULL>	<NULL>	1470	Evaluation of pharmacists’ knowledge about dispensing of drugs after completing a training course	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo	Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7mbrp3	<NULL>	"Participants must be registered at the Regional Council of Pharmacy of the state where they work.
According to data from the Federal Council of Pharmacy; Brazil has approximately 70.576 pharmacies that dispense drugs. Whereas each of them must rely on the assistance of at least one pharmacist; the minimum study population is 70.576 professionals.
From this population; the sample target will be 2000 individuals aged at least 18 years. There is no maximum age for the inclusion of individuals."	Not to be updated with the professional documentation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-9rcxbq	Evaluation of body fat measurements to predict risk of Heart Disease in HIV-positive patients using Cocktail	Data analysis completed	Observational	2017-11-14	<NULL>	<NULL>	1477	Assessment and proposed cutoffs for adiposity indices to predict Cardiovascular Risk in HIV-infected patients on Antiretroviral Therapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-04-13	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9rcxbq	<NULL>	HIV positive test; age between 18 and 60 years; stable HIV patients (no signs or symptoms of opportunistic infections); use of HAART and stable weight (&lt;10% change during the last year).	presence of edema; thyroid disease; chronic renal insufficiency; pulmonary disease; hepatic alterations; signs or symptoms of opportunistic infections; presence of a pacemaker or a metal prosthesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-9xcx69	Sclerotherapy with Ethanolamine Oleate of Oral Vascular Anomalies: What is the Ideal Concentration?	Data analysis completed	Intervention	2017-11-21	<NULL>	<NULL>	1486	Sclerotherapy with 5% Monoethanolamine Oleate Foam in Treatment of Vascular Malformations of the Head and Neck Region: A Case Series	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-02	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9xcx69	<NULL>	Patients with oral vascular anomalies less than 20 mm;diagnosis of based on the Mulliken and Glowacki (1982; indications for treatment of these lesions included pain; growth; swelling; pressure or esthetics.	"oral vascular anomalies larger than 20mm
Lesions that do not have the clinical diagnosis of vascular anamolias.
Patients with a history of allergy to the drugs used."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4t35tk	Evaluation of ultrasound impact on deep venous catheterization in children admitted to the Intensive Care Unit of the Clinical Hospital - Unicamp.	Data analysis completed	Intervention	2017-11-21	<NULL>	<NULL>	1488	Evaluation of ultrasound impact on central venous catheterization in pediatric patients admitted to the Intensive Care Unit of the Clinical Hospital - Unicamp	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Hospital das Clínicas da Universidade Estadual de Campinas	Hospital das Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4t35tk	<NULL>	"Patients aged 28 days to 14 years who required central venous access (at the discretion of the attending physician);
Patients admitted at PICU in the presence of at least one of the researchers"	"Children with internal jugular vein thrombosis;
Children with coagulation disorders;
Children with tracheostomy;
Children who underwent cannulation of veins other than internal jugular veins"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4ndjtp	Effects of Acupuncture for Pain Improvement and Quality of Life in Women with Fibromyalgia	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	1491	Effects of Acupunture at the yanglinquan point (vb-34) on quality of life in women with Fibromialgia: a pilot clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4ndjtp	<NULL>	Be between 18 and 60 years of age; be female; have a clinical diagnosis of Fibromyalgia.	To present lesions, injuries and sensitivity impairment in the skin that makes it impossible to apply the modality; use topical medications in the region of the modality; presence of scars or prostheses in the place that could compromise the insertion of the needle.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-4hv9rs	Comparison of the effects of Inspiratory Muscle Training and Aerobic Training in people on Hemodialysis	Data analysis completed	Intervention	2015-06-08	<NULL>	<NULL>	1493	Comparison of the effects of Inspiratory Muscle Training and Aerobic Training of the lower limbs in physiological and functional parameters in Hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-09	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4hv9rs	<NULL>	Were included patients with chronic kidney disease on hemodialysis for longer three months and weekly frequency of three times a week;  hemodialysis access by arterio-venous fistula.	Systolic blood pressure greater than 180 mmHg or diastolic blood pressure greater than 120 mmHg,  ischemic heart disease, recent myocardial infarction (less than 6 months), complex ventricular arrhythmia, aortic stenosis, severe metabolic disease, severe anemia and aortic aneurysm; respiratory diseases, neurological or musculoskeletal that compromises the protocol execution; inability to perform any stage of protocol; absence in three consecutives exercise sessions; changes of clinical treatment during study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-2yxy7z	The effect of Art therapy in conjunction with the drug treatment of Depression in the elderly	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	1494	Art Therapy and Depression: Effects of Art Therapy as a Complementary Therapy for the Treatment of Depression in the Elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-18	Hospital das Clínicas da Faculdade de Medicina da USP	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2yxy7z	<NULL>	"Age equal to or greater than 60 years, to be literate,to be female.
Diagnosis of depression.
Being on medication for depression, at the stage of relapse prevention, that is, at the maximum dose desired and with symptoms at most moderate (GDS &lt;10).
Agree to participate in the study and fill out the Informed Consent Form, pursuant to Resolution 196 of the National Health Council.
Have a commitment to participate in the program for a period of 20 weeks."	Dementia, Chemical dependence, clinical degenerative disease or associated with high morbidity and mortality	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-3fg9cd	Effect of Strength Training associated with muscular electric current on the structure and function of knee extensor muscles	Data analysis completed	Intervention	2017-11-23	<NULL>	<NULL>	1497	Effect of Strength Training associated with Neuromuscular Electrical Stimulation on a structure and function of knee extensor muscles	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-09	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3fg9cd	<NULL>	Undergraduate and graduate students; healthy; aged between 18 and 35 years.	Volunteers with the presence of any health condition that contraindicates or impairs the performance of high intensity exercises; history of knee surgery; a recent picture of musculoskeletal injuries in the lower limbs; subjects engaged in systematic training programs during the collection period; subjects engaged in lower limb strength training programs within 3 months prior to the study; users of ergogenic supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2cfy62	The Influence of Pilates Soil on Separation of the Rectus abdominis muscle in Women in the Climatério	Data analysis completed	Intervention	2017-11-24	<NULL>	<NULL>	1499	The Influence of mat Pilates in the Diastasis of rectus abdominis muscle  in women in Climatory Syndrome:Clinical Trial Randomized Single-blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-08	Universidade Sagrado Coração	Universidade Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2cfy62	<NULL>	Women; Climacteric Syndrome; Abdominal Dystopia.	TUrinary Tract Infections; Neurological Diseases; Osteomyoarticular Dysfunctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-8sx73k	The effects of intensive therapy on the performance of day-to-day activities in post-stroke individuals	Data analysis completed	Intervention	2017-11-24	<NULL>	<NULL>	1501	The effects of constraint induced movement therapy on the functionality and occupations of individuals after stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-24	Associação de Assistência à Criança Deficiente	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8sx73k	<NULL>	older than 18 years; medical diagnosis of stroke with more than 6 months of injury; clinically stable; asymmetry in the functional use of the upper limbs, determined by the motor activity log scale, quantity subscale with value less than 3; classified as grade 2 or 3 according to the presence of active motor function of the affected upper limb according to the functional level scale of the University of Alabama research group; be able to perform the first four items of the wolf motor functional test; have agreed and signed the Free and Informed Consent Form.	pain that interferes with therapy and home activities; more than two consecutive absences during the protocol; participants who do not comply with the proposed protocol of each group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-4zvpwb	Comparison of Physiotherapeutic treatments for urine leakage	Data analysis completed	Intervention	2017-11-27	<NULL>	<NULL>	1505	Comparison of the Pilates Mat Method with Perineal Exercises in the treatment of Stress Urinary Incontinence and on Pelvic Floor Muscle Function in women between the ages of 40 and 65	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Faculdade de medicina de Marilia	Faculdade de medicina de Marilia	https://ensaiosclinicos.gov.br/rg/RBR-4zvpwb	<NULL>	Multiparous women in the age group of 40 to 65 years; to present stress urinary incontinence; sign the Informed Consent Form	Prior physical therapy treatment for incontinence urinary stress, or any type of structured and planned physical activity during the study period; already had some surgery of the urinary tract; diagnosis of urinary tract infection, cystitis or genital prolapse; being pregnant; women who could not, even with all the researcher&apos;s attempts at awareness, contract the pelvic floor musculature correctly during the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-8w27x5	Role of fibroblast growth factor 23 (FGF2) in Bone Disease in increased urine calcium loss	Data analysis completed	Observational	2017-12-01	<NULL>	<NULL>	1506	Role of the Fifroblastic growth factor 23 (FGF2) in the Bone Disease in Idiopathic Hypercalciuria	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-01-14	Faculdade de Medicina da Universidade Federal de Minas Gerais	Children's Mercy Hospital	https://ensaiosclinicos.gov.br/rg/RBR-8w27x5	<NULL>	Pediatric patients; both genders; with diagnosis of Idiopathic Hypercalciuria; age between 3 and 21 years; with diurnal and nocturnal urinary sphincter control.	Pregnant adolescents; patients with nephrocalcinosis; chronic immobilization; hypercalcemia; history of malignancy; excessive intake of calcium and vitamin D; hyperuricemia; prolonged corticoterapia; renal tubular diseases; use of drugs that interfere with calcium metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-9dvpr4	Effectiveness of Exercise in Water on physical and functional performance in people with Chronic Back Pain	Data analysis completed	Intervention	2017-12-01	<NULL>	<NULL>	1509	Effectiveness of Aquapilates on physical and functional performance in patients with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9dvpr4	<NULL>	"Age of 50 to 70 years;
Present non-specific low back pain for more than 3 months;
Have not undergone any surgery in the spine or other surgeries that make the exercises impossible;
Do not present any infection or neoplasms;"	"Individuals who had surgery on the spine;
Have heart failure or any other heart disease;
Chlorine allergy;
Hydrophobia;
Absence of sphincter control;
Neurological disorders;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-3xfyhh	Comparison of the amount of air expelled by elderly women before and after respiratory exercises	Data analysis completed	Intervention	2017-12-06	<NULL>	<NULL>	1510	Comparison of the Expiratory Flow Peak among elderly women before and after respiratory exercises	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-10	Universidade Presidente Antônio Carlos	Universidade Presidente Antônio Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3xfyhh	<NULL>	Elderly cooperatives; with good cognition; conscious; carriers of heart; metabolic; renal and hepatic diseases; obese; and sedentary women; who answered the Cardiovascular Risk Stratified Questionnaire and who agreed to the Free and Informed Consent Form.	Age less than 65 and greater than 85 years; with high cognitive deficit; tracheostomized; smokers; patients with respiratory and neurological diseases; chauffeured; bedridden; with dementia and that they exposed any conditions that prevented them to carry out the proposed exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2w7mh7	Evaluation of the effect of a Healing Oil on the treatment of Diabetic Foot Cracks	Data analysis completed	Intervention	2017-12-11	<NULL>	<NULL>	1514	Healing Oil for the treatment of Cracks in the Diabetic Foot	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-02	Programa de Pós-Graduação em Patologia da Universidade Federal Fluminense	Programa de Pós-Graduação em Patologia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-2w7mh7	<NULL>	Type 2 diabetic patients. Adults. Both genders. Registered at ADINF (Associação de Diabéticos de Nova Friburgo, RJ). With xerosis (dry skin). Fissures (cracks) in their feet.	Type 1 diabetic patients. Those with ulcers in their feet. Patient taking medicine for the treatment of the fissures in the skin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2n2gsw	A comparison between the effects of two substances for superficial anesthesia on human gums.	Data analysis completed	Intervention	2017-12-11	<NULL>	<NULL>	1515	Comparative analysis of the effectiveness of  EMLA®( Euthetic Misture of Local Anesthetic) (Prilocaine 2,5% and lidocaine 2,5%) and benzocaine 20% on topical anesthetic in human&apos;s gengival mucosa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-20	Instituto Leão Sampaio de Ensino Universitário Ltda	Instituto Leão Sampaio de Ensino Universitário Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2n2gsw	<NULL>	Healthy volunteers; not pregnant; non smokers; not infants; no history of allergies to local anesthetics; without chronic use of medications; with complete natural dentition and no reports of numbness in the face or oral cavity	Volunteers with chronic diseases; pregnant women; smoking; infants; with a history of allergy to the local anesthetic and changes in face and mouth sensitivity; volunteers who did not attend the second visit and who did not have the medical records completely filled	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8k5jsj	Evaluation of the influence of metabolic and genetic factors on energy regulation in stomach reduction surgery	Data analysis completed	Observational	2017-12-21	<NULL>	<NULL>	1535	Assessment of the influence of metabolic and genetic factors on energy homeostasis after Bariatric Surgery	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-05	Instituto de Biociências de Botucatu - UNESP	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-8k5jsj	<NULL>	Being female; Age between 20 and 45 years in menacme; Body Mass Index greater than 40 kg / m2 and less than 60 kg / m2; Waiting in the queue to perform the surgical procedure; Do not present diseases that cause changes in energy metabolism such as diabetes mellitus, hypothyroidism, HIV infection, neoplasms, heart diseases, nephropathies and liver diseases; Do not present diseases that cause edema such as venous insufficiency, pregnancy, thrombosis, sepsis, inflammation, lymphedema; Do not use medicines that cause metabolic and absorptive changes such as diuretics, amphetamines, thyroid hormones, topiramate, orlistat, corticosteroids, etc.	We excluded women who did not present optimal health conditions for the surgical procedure (diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies) after conducting the admission tests for the research and patients living outside the DRS-10 region (near the collection site).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-69fnqt	Use of Acupuncture in the treatment of Dry Mouth and Oral Wounds caused by treatment in patients with head and neck Cancer	Data analysis completed	Intervention	2017-12-21	<NULL>	<NULL>	1539	Use of Low-power Laser Therapy and Acupuncture in the treatment of radio-induced Mucositis and Radiodermatitis in patients with head and neck Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Estadual de Montes Claros	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-69fnqt	<NULL>	Histopathological diagnosis confirmed squamous cell carcinoma of the head and neck; Age over 20 years of age; In need of radiotherapy treatment; both sexes; Agree to participate in the study	Individuals who do not have capacity or have limitations that prevent them from responding to the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:00
RBR-4hsyy4	Comparison between Pethidine and Dipyrone as Analgesics during Labor	Data analysis completed	Intervention	2018-01-04	<NULL>	<NULL>	1545	Labor Analgesia: Comparison between low doses of Pethidine and Sodium Dipyrone	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-05-28	UNIFOR - Universidade de Fortaleza	Secretaria municipal de saúde de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4hsyy4	<NULL>	Presence of at least 3 uterine contractions lasting 40 seconds or more every 10 minutes; Patients presenting a dilation of the uterine cervix equal to or greater than 5 cm; Measurement of pain through the use of visual analogue scale equal to or greater than 8; Gestational age of 37 up to 40 weeks and 6 days; Fetuses in cephalic presentation	Parturients with any of the following events: poorly controlled arterial hypertension, diabetes, restricted intrauterine growth and placental abruption; Use of oxitocyn by pregnant women in the period from the begining of labor until 2 hours after administration of the analgesic; Hypothyroidism diagnosed previously and without therapy; Patients taking monoamine oxidase inhibitors; Occurrence of labor less than 1 hour after analgesia; Parturients with body mass greater than 100 kg; Indication of cesarean delivery during admission; Addison&apos;s disease previously diagnosed; BCF&apos;s &lt; 110 bpm, during admission; BCF&apos;s &gt; 160 bpm, during admission; Patients allergic to sodium dipyrone; Patients allergic to pethidine; Users of chlorpromazine; Phenobarbital users; Phenytoin users; Fetus without vilality; Twin pregnancy; Drug addiction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-5zbgpp	Acupuncture as Treatment of Cervical Wound and Avaliation of Regeneration Process Factors	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1547	Treatment of Cervical Gladular Epithelium Ectopy with Sistemic Acupuncture and Analisys of Interference Factors in the Metaplasic Process	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5zbgpp	<NULL>	women in the menamma with ectopy of the cervical glandular epithelium on the cervical surface in the vaginal environment without any previous treatment	non-pregnant, non-lactating, nonimmunosuppressed of any kind	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-2bzdm3	Cow milk with higher concentration of Selenium and Vitamin E improves children&apos;s health	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1548	Effects of the inclusion of Sunflower Oil with addition of Selenium and Vitamin E in the diet of lactating cows on the production and milk composition and its influence on human nutrition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Faculdade de Zootecnia e Engenharia de Alimentos	Agência Paulista de Tecnologia dos Agronegócios	https://ensaiosclinicos.gov.br/rg/RBR-2bzdm3	<NULL>	healthy volunteers; both genders; age between 8 and 10 years; did not use compulsory medication	volunteers aged less than 8 years and over 10 years; volunteers who stayed 2 consecutive days without receiving milk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-5hm62q	Effects of Unripe Banana Flour on blood tests and anthropometric data on Overweight and Visceral Fat subjects	Data analysis completed	Intervention	2018-01-05	<NULL>	<NULL>	1550	Evaluation of the effects of regular consumption of Unripe Banana Flour on the metabolic and anthropometric parameters of Overweight Individuals and Visceral Adiposity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5hm62q	<NULL>	Women between the ages of 20 and 50; Body mass index greater than or equal to 25 kg / m² and less than 40 kg / m²; Waist circumference greater than or equal to 80 cm; Not having participated in a weight loss program in the last six months; Be healthy.	Cigarette smoker volunteers; history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; being pregnant or nursing; practice restrictive diets; allergic reactions to any of the components of the shake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-3kxkzn	Effect of training in vibrating plataform in subjects with Chronic Obstructive Pulmonary Disease	Data analysis completed	Intervention	2015-08-28	<NULL>	<NULL>	1553	Effect of whole-body vibration training in subjects with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-3kxkzn	<NULL>	75 subjects of both genders; with stable COPD; age between 45 and 80 years; women after menopause.	Acute or chronic associated disease not stable; included in  some form of physical training; use of antiinflammatory and immunosuppressive medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-397qws	Effect of Transcutaneous Electric Nerve Stimulation (TENS) in delayed onset muscle soreness (DOMS): prevention and treatment	Data analysis completed	Intervention	2018-01-08	<NULL>	<NULL>	1558	Effect of TENS in Delayed Onset Muscle Soreness (DOMS): prevention and treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-05	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-397qws	<NULL>	Healthy; physically inactive volunteers; both sexes; aged 18 to 40 years.	Previous experience with the use of TENS; muscoloskeletal disorders; heart diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-5hhnmx	The evolution of psychiatric care in municipality of Sorocaba in São Paulo - Brazil: from a hospital-based model to full deinstitutionalization	Data analysis completed	Observational	2018-01-12	<NULL>	<NULL>	1566	Matrix support in mental Health in primary care: strategy for resolving and satisfying the team	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Fundação São Paulo - Campus Sorocaba da Pontifícia Universidade Católica de São Paulo	Pontificia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5hhnmx	<NULL>	Health Care Professionals. Both genders. Between 18 and 70 years.	Workers in other áreas. Both genders. Between 18 and 70 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-8mwkyq	A Experimental Study in Type 2 Diabetes Patients	Data analysis completed	Intervention	2018-01-18	<NULL>	<NULL>	1576	Effect of Aerobic Train in the Type 2 Diabetes Patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-29	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8mwkyq	<NULL>	patients had to be voluntary; both gender; body mass index  igual or above 25 kg/m²; sedentary and diagnosed with T2DM	history of alcohol or drug abuse; diagnoses of cardiac pathologies; not being obese and sedentary; uncontrolled blood glucose spikes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-69g952	Non-pharmacological techniques for cognitive improvement in schizophrenia	Data analysis completed	Intervention	2018-01-18	<NULL>	<NULL>	1578	Investigation of the Effects of Neurostimulation Techniques in Schizophrenia and Their Impact on Executive Functioning	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-69g952	<NULL>	Subjects between 18 to 65 years old diagnosed with schizophrenia; No history of substance abuse/dependence, in exception to tobacco and/or caffeine;  No diagnosis of any neurological conditions (e.g. Parkinson’s disease); (d) No history of seizures;  No unexplained loss of consciousness; Stability of pharmacological treatment for at least 6 weeks; No contraindications to tDCS, such as metal in the head or implanted brain medical devices; No pregnancy at enrollment; acceptance to participate in the study and provide the written informed consent.	Subjects with psychiatric diagnoses other than schizophrenia, except bu the health controls; Subjects with schizophrenia with predominant positive symptoms; Subject illiterate or unable to complete the cognitive assessment; IQ &lt; 70; Clinically relevant suicide risk. Dropout was considered after absence in two consecutive tDCS sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-358t6g	II Health diagnosis of mothers and children of Alagoas State	Data analysis completed	Observational	2018-01-18	<NULL>	<NULL>	1580	II Health Diagnosis of Maternal and Child Population of Alagoas State	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-04-05	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-358t6g	<NULL>	All the individuals of the maternal and child group (women of reproductive age, pregnant women, mothers, children and adolescents) residing in the selected households.	women aged over 50; male over 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-23h9cy	Comparison of the Acute Effects of Traditional versus Power Training on Metabolic, Cardiovascular and Psychophysiological Responses in Elderly Hypertensive Women	Data analysis completed	Intervention	2018-01-23	<NULL>	<NULL>	1588	"Comparison of the Effects of Eccentric Strength Training and Muscle Power
on Neuromuscular, Functional and Biochemical Variables in Elderly Individuals"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-17	Universidade Federal do Piauí - UFPI	Universidade Católica de Brasília - UCB	https://ensaiosclinicos.gov.br/rg/RBR-23h9cy	<NULL>	hypertensive women; with above 60 years; without experience with RT in the previous six months.	Subjects with physical disabilities; diagnosis of diabetes; CVDs; hypertension (systolic blood pressure [SBP] 180 mm Hg; diastolic blood pressure [DBP] 110 mm Hg); musculoskeletal disease; or who smoked; or abused drugs/alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-6c7rq4	Neck rehabilitation in subjects with temporomandibular pain. A randomized controlled clinical trial	Data analysis completed	Intervention	2016-05-10	<NULL>	<NULL>	1592	Neck rehabilitation in subjects with Temporomandibular Disorders. A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal de São Carlos- UFSCar	Universidade Federal de São Carlos- UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-6c7rq4	<NULL>	Females; 18-40 years; temporomandibular disorders diagnosis; temporomandibular joint pain or masticatory muscles pain for more than three months; presence of tender points on palpation of masticatory muscles.	Subjects in dental treatment or other treatment of orofacial; rheumatic disease; tooth loss; fibromyalgia; systemic neurological sistemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-98wzgn	Evaluation of Muscle Electrical Stimulation and Creatine Supplementation in Renal Hemodialysis Patients	Data analysis completed	Intervention	2018-01-25	<NULL>	<NULL>	1595	"Evaluation of Eletro  Neuromuscular Stimulation and Supplementation of
Creatine in Renal hemodialysis Patients"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-98wzgn	<NULL>	Patients with a diagnosis of chronic kidney disease; undergoing hemodialysis for more than 3 months; of both sexes; and aged between 18 and 59 years	Patients with neurological diseases; severe cardiovascular diseases; physical impairments (amputations, deep vein thrombosis); and patients who underwent long-term and structured high-resistance training three months prior to the date of inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-2jx9r5	Efficacy of Tranexamic Acid for Dental Extractions in patients with Inherited Bleeding Disorders	Data analysis completed	Intervention	2018-01-29	<NULL>	<NULL>	1601	Topical versus systemic use of Tranexamic Acid in patients with Inherited Bleeding Disorders undergoing Dental Extractions: a multicenter study	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-03-09	Centro de Hematologia e Hemoterapia - HEMOCENTRO	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRPUSP)	https://ensaiosclinicos.gov.br/rg/RBR-2jx9r5	<NULL>	Adult patients (over 18 yrs old); Patients with inherited bleeding disorders; Male and females; Patients in follow up at Hemocentro de Campinas/UNICAMP and/or at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCFMRP-USP); Patients who need at least one tooth to be removed;	"Patients who disagree with the terms of the informed consent; Patients who are incapable to give your own consent due to psychiatric and/or mental reasons; Under age patients (less than 18 yrs old); Pregnant women and/or breastfeeding women; Edentulous patients;
6- Hemophilic patients with inhibitors against coagulation plasmatic factors; Patients with high risk for thrombosis, or with a previous thromboembolic event; Patients who had a previous hypersensibility reaction related to tranexamic acid use; Patients who have used acetylsalicylic acid, or non-steroidal anti-inflammatory drugs up to two weeks before the dental extraction."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-4dkhh3	Initial prostate biopsy: 12 versus 20 cores - prospective study	Data analysis completed	Intervention	2018-01-29	<NULL>	<NULL>	1602	20 core transrectal prostate biopsy is the initial approach of choice in a selected group of patients with suspected prostate adenocarcinoma	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal de São Paulo	Fundação de Apoio à Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4dkhh3	<NULL>	"Patients referred for a prostate biopsy with suspected prostate cancer: positive
digital rectal exam findings and/or elevated serum prostatic-specific antigen levels."	Previous prostate biopsy and/or prostatic-specific antigen greater than 20 ng/ml	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-9m95rx	Effects on the heart, blood vessels, and psychological and social aspects following three types of bodybuilding training in men with high blood pressure	Data analysis completed	Intervention	2018-01-30	<NULL>	<NULL>	1603	Association of cardiovascular and functional effects of different methods of resistance training with psychosocial aspects of men with high blood pressure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-15	Universidade Federal do vale do São Francisco	Universidade Federal do vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-9m95rx	<NULL>	Be resident in the cities of Petrolina / PE or Juazeiro / BA; present age between 40 and 60 years; be sedentary; (ABPM) with mean values of 24h, wakefulness or sleep greater than 125, or 110 mmHg, respectively in the systolic BP or greater than 75, or 70 mmHg, respectively in the diastolic BP, which characterizes the individual with BP elevated according to VI Brazilian Guidelines on Hypertension (2010); body mass index above 25 kg / m².	The BP, although elevated as highlighted in the previous item, should be controlled during resting measures performed in a laboratory environment, being lower than 160 and 105 mmHg for systolic and diastolic BP, respectively; to present systemic hypertension diagnosed; presenting cardiometabolic diseases or dysfunctions in the health history, such as musculoskeletal limitations, that may compromise physical integrity and participation in the study, mainly diseases of the cardiovascular system; make use of some type of drug related to blood pressure control during the study participation, if they use for other purposes inform the researcher; the maintenance of the proposed training frequency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-2nxt6y	The effect of  Balance Problems Treatment  in health centers	Data analysis completed	Intervention	2018-01-31	<NULL>	<NULL>	1607	The effectiveness of the Vestibular Rehabilitation Program in primary health care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Secretaria Municipal de Saúde de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-2nxt6y	<NULL>	To be a SUS’ user; resident or worker in the areas covered by the Cabana and Vista Alegre Health Centers; be 18 years of age or older; have a medical indication to participate in the vestibular or Lian Gong Rehabilitation groups; sign the TCLE.	Presence of intellectual or physical disability or mental disorders that prevent the proposed activities in the groups; withdrawal of treatment; nonadherence to treatment with more than four absences; pregnancy; speech-language evaluation compatible with Benign Paroxysmal Positional Vertigo (BPPV).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-4gh83t	Hope as a process that preserves mental health	Data analysis completed	Intervention	2018-01-31	<NULL>	<NULL>	1609	Hope as Cognitive and Behavioral process: a new Clinical Strategy for the prevention of Mental Health in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-10	Faculdade de Medicina do ABC Paulista	Supera Ginástica Cerebral	https://ensaiosclinicos.gov.br/rg/RBR-4gh83t	<NULL>	60 years or more; both genders; voluntary participation; healthy volunteers; being integrated in a program of cognitive stimulation (cerebral gymnastics).	less than 60 years old; dementia diagnosed;  not being in a program of cognitive stimulation (cerebral gymnastics)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-8t7ssv	Effectiveness of nutritional intervention, based on the Trasnteorical Model for weight control, in Primary Health Care services.	Data analysis completed	Intervention	2018-01-31	<NULL>	<NULL>	1611	Effectiveness of nutritional intervention in Primary Health Care belonging to Health Promotion Project - BH + Healthy: Belo Horizonte, Minas Gerais.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-27	Universidade Federal de Minas Gerais - UFMG	Secretaria Municipal de Saúde de Belo Horizonte -SMSBH	https://ensaiosclinicos.gov.br/rg/RBR-8t7ssv	<NULL>	For a definition of eligible criteria, are women; using frequent to service activities (frequent in the last month in physical exercises); to be 20 years old or older; to have obesity for adults - Body Mass Index (BMI) &gt;= 30 kg / m2 (WHO, 1995) and overweight for the elderly - BMI&gt; 27 kg / m2 (NSI, 1992).	Individuals with compromised mental health that prevented responding to the questionnaire and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-3tnjtq	Analysis of the Effects of Caffeine on cognitive abilities and anxiety	Data analysis completed	Intervention	2018-02-01	<NULL>	<NULL>	1619	Analysis of the Effects of Caffeine on cognitive abilities and anxiety	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Departamento de Biociências da Universidade Federal de São Paulo - Baixada Santista	Departamento de Biociências da Universidade Federal de São Paulo - Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-3tnjtq	<NULL>	healthy volunteers, both genders; age between 18 and 40 years; students of UNIFESP Baixada Santista;  minimum of 11 years of school education.	psychiatric diagnoses; obesity; dyslipidemia; cardiopathy; gestation; intellectual, visual and auditory deficiency; HIV on antiretroviral therapy; cirrhosis; renal failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-5ss7g7	Effects of sweeteners on the blood glucose and food intake	Data analysis completed	Intervention	2018-02-05	<NULL>	<NULL>	1628	Effects of high-intensity sweeteners on glycemic response and their acute impact on food intake	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5ss7g7	<NULL>	Eligibility criteria included adult (20-40 years old), eutrophic (BMI ranging from 18.5 and 24.9 kg /m2), with adequate body fat percentage (women: 20 to 30% and men: 12 to 20%), non-consumers of sweeteners and/or diet and light products (at least once a week), no smoking habits, not be pregnant or lactating and no family history of diabetes or glucose intolerance, no allergy or aversion to food tested in the study, no use of drugs that affect glycaemia or appetite, stable weight (change &lt; 3 kg in the last 3 months) and not on a weight loss diet.	Individuals outside the specified age group and body composition, smokers, pregnant or lactating women; with glycemic changes or a family history of diabetes or glucose intolerance; users of drugs that affect glycaemia or appetite, individuals with weight instability or on a weight loss diet, as well as all volunteers who express an interest in withdrawing from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9kqvnz	Short-term motor control adaptations after a Single Robotic therapy associated with the Video game	Data analysis completed	Intervention	2018-02-06	<NULL>	<NULL>	1633	Short-term sensorimotor adaptations after a single robotic therapy associated with the video game	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-25	Universidade Federal de São Carlos	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9kqvnz	<NULL>	The individuals with hemiparesis were not linked to any rehabilitation programs and this experience was the first contact with robotic therapy. The following inclusion criteria were considered 6 or more months post-stroke; men or women aged between 50 and 75 years; low spasticity: less than level 3 on the modified Ashworth scale so that the individual would be able to perform the isokinetic test; and independent overground walking levels 2 and 5 according to the Functional Ambulation Categories. The control group participants had to score greater than 8 on the Physical Activity Questionnaire Basal, which indicates they were not sedentary. This is important because sedentary people have deleterious modifications in the neuromuscular system; individuals from the control group performed physical activity, mainly aerobic activities, at least 3 times a week. No further criteria regarding the physical activity level were used.	Clinical signs of severe heart failure or chronic metabolic disease; severe cognitive or communication impairments; minimum score on the Mini-Mental State Examination according to the education level; [19] a history of lower limb injuries, deformity or contractures of the ankle joint; a smaller range of motion than 10o for dorsiflexion and 20o for plantarflexion; sensory deficits and neglect absence defined by clinical exams. Bell’s and Clock drawing tests were used to identify the neglect. [20, 21] Six or more errors indicate visuospatial hemineglect in the Bell´s test. Concerning the Clock drawing test, neglect patients are often found to omit numbers or to place all of the numbers on the right-hand side of the clock face.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-2zk6yc	Comparison of three methods to measure the feeding tube in newborns	Data analysis completed	Intervention	2018-02-07	<NULL>	<NULL>	1636	Length of the gastric tube in newborns: comparison between three methods of measurement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Estadual de Campinas	Caism - Hospital da Mulher Prof. Dr. José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-2zk6yc	<NULL>	"Newborn; both genres; need a gastric tube; do not present any type of congenital malformation or syndrome; have not suffered
surgical procedure in the gastrointestinal system."	"newborn who is seriously ill; under minimal care; has a medical contraindication
of nasopharyngeal tube; severe hypothermia that prevents the X-ray, ultrasonography,
weighing and length verification."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-8gcd45	Clinical Evaluation of Dental Restorations in Composite Resin made 14 years ago	Data analysis completed	Observational	2018-02-07	<NULL>	<NULL>	1637	Clinical Evaluation of Restorations in Composite Resin Packable and micro-hybrids performed 14 years ago	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Faculdade de Odontologia da Universidade Federal de Pernambuco	Faculdade de Odontologia da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8gcd45	<NULL>	Patients with indication of restoration in at least 3 posterior teeth; good oral hygiene condition; healthy or properly restored antagonistic teeth.	Have made any changes in the restorations, replacements, repairs, prostheses; loss of dental elements analyzed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-6c65dw	Joint manipulation and electrotherapy in cervical pain	Data analysis completed	Intervention	2018-02-20	<NULL>	<NULL>	1645	Evaluation of the effects of chiropractic and transcutaneous electrical nerve stimulation (tension) on pain relief in patients with of mechanical origin neck pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-16	Associação Teresinense de Ensino SC LTDA	Associação Teresinense de Ensino SC LTDA	https://ensaiosclinicos.gov.br/rg/RBR-6c65dw	<NULL>	To be between 20 and 39 years of age; to be of both sexes; to have cervicalgia of mechanical origin.	Present a positive result for the klein test; acute fracture; spinal cord tumor; acute infections; malignant spinal neoplasm; frank disc herniation with signs of progressive neurological deficit; neoplasms of muscle tissue or other soft tissues; generalized congenital hypermobility; syringomyelia; hydrocephalus of unknown etiology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-225ksb	Effects of muscle fatigue on knee sensitivity	Data analysis completed	Intervention	2018-02-21	<NULL>	<NULL>	1648	The influence of femoral quadriceps muscle fatigue on joint knee proprioception	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Universidade São Judas Tadeu	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-225ksb	<NULL>	Healthy volunteers, classified as active, according to the International Physical Activity Questionnaire, without previous injuries in the lower limbs.	To present pathologies in incapacitating levels; having a diagnosis of fibromyalgia or rheumatoid arthritis; participation in a neuromuscular strengthening or exercise program or other (non-pharmacological) treatment for the knee in the last six months; prosthesis or any other surgery on the hip and knee joints; decompensated heart diseases; hearing or visual impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-6759yz	Treatment of pain and damage of the Joint of the Mandible by means of Injection of Hialuronato de Sódio Medicine	Data analysis completed	Intervention	2018-02-23	<NULL>	<NULL>	1653	Evaluation of the Efficacy of Sodium Hyaluronate Injection in the treatment of signs and symptoms of Temporomandibular Joint Dysfunctions	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2016-02-02	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6759yz	<NULL>	Individuals from 18 to 70 years; of both sexes; with clinical and imaging diagnosis of disc displacement of the temporomandibular joint with or without reduction	Patients with rheumatologic diseases, neuropathic pain or history of previous TMJ surgery, trauma or fractures; Patients previously submitted to therapy by viscossuplementation, arthroscopy or arthrocentesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-5pgxys	Use of the modulated frequency system for unilateral hearing loss	Data analysis completed	Intervention	2018-02-26	<NULL>	<NULL>	1656	Unilateral hearing loss: effectiveness of the FM system	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-10	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-5pgxys	<NULL>	Individuals between 5 and 17 years old; with diagnosis of unilateral hearing loss; adapted with a hearing aid for a minimum period of one year, with daily use of 8 hours confirmed by datalogging; enrolled in regular school; after adapting to regular use of the FM System during the school period.	Diagnosis of bilateral hearing loss; not to make effective use of the hearing aid; not properly enrolled in regular school.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-8btc25	Effects of Aquatic Exercise on cardiovascular risk factors and cardiac autonomic modulation of postmenopausal women with Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2018-02-27	<NULL>	<NULL>	1661	Effect of Aquatic Exercise on the autonomic modulation of the heart rate of postmenopausal women with Diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-15	Universidade de Marília	Universidade Estadual Paulista - Faculdade de Filosofia e Ciência - Campus Marília	https://ensaiosclinicos.gov.br/rg/RBR-8btc25	<NULL>	Being a woman between the ages of 50 and 85 years; amenorrhea for at least 12 months (postmenopausal state); not having performed systematic exercise in the last 3 months; presenting a diagnosis of type 2 diabetes mellitus for at least 3 years.	Inability to enter and exit pool independent; inability to understand and attend simple verbal command; amputations and / or prosthesis use in limbs; sequelae of stroke; Parkinson&apos;s disease; fractures in lower limbs and / or spine after age 60; incapacitating labyrinth; otitis; hydrophobicity; skin lesions; deformity of the feet. criteria of non-inclusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-4qd567	How Physical Exercise influences the Perception of Pain of women with Chronic Pelvic Pain	Data analysis completed	Intervention	2018-03-02	<NULL>	<NULL>	1670	Effects of Exercise Therapy on Pain Threshold in Chronic Pelvic Pain women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qd567	<NULL>	"Study group: women of reproductive age with chronic pelvic pain;
Control group: apparently healthy reproductive age women."	Pregnant women; physically active in competitive level; malignancies, dyspareunia and/or isolated dysmenorrhea	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-7ybwkm	Clinical evaluation in humans of alveolar bone preservation after filling by bovine composite bone substitute	Data analysis completed	Intervention	2018-03-02	<NULL>	<NULL>	1674	Evaluation of the maintenance of alveolar bone volume in humans, after filling with bone composite of bovine origin, clinical evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Faculdade de Odontologia de Araçatuba - UNESP	Centro de Pesquisas São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-7ybwkm	<NULL>	Healthy patients, surgical risk ASA I; requiring extraction of a single uniradicualar tooth for posterior placement of osseointegrated implant; without periapical lesion; or periodontal disease; and preserved alveolus with 5 wall after the surgical procedure of tooth extraction.	Patients with incompatible age established by the study; patients with systemic diseases; smoking patients; patients with periodontal disease or periapical lesion; and patients who after the exodontia procedure did not present the alveolus preserved with 5 walls.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4dvx2p	Study about new device for urinary incontinece	Data analysis completed	Intervention	2018-03-06	<NULL>	<NULL>	1677	SUPERA: Permanent, Removable and Self-Sustaining Urethral Probe for the Treatment of Incontinence and Urinary Retention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco - HC-UFPE	https://ensaiosclinicos.gov.br/rg/RBR-4dvx2p	<NULL>	Female patients with neurogenic bladder and participants in the clean intermittent catheterization program.	Patients with urethral deformities and active urinary tract infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4kxxd5	Parental orientation for sleep problems in childhood	Data analysis completed	Intervention	2017-03-27	<NULL>	<NULL>	1689	Behavioral intervention  for sleep problems in childhood	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-04	Instituto de Psicologia da Universidade de São Paulo	Instituto de Psicologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4kxxd5	<NULL>	Parents / caregivers of children from one to five years of age who have behavioral problems related to sleep. The child must have any of the following characteristics listed below at a frequency of at least three times a week. The child takes about 30 minutes or more to fall asleep; The child resists and / or protests to go to bed; The child wakes up at night; The child only sleeps in the presence of the parents.	Children with neurological impairment; Children with psychiatric diagnosis; Children whose sleep problems are due to physiological conditions and children whose caregivers could not attend face-to-face sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-4wg3g3	Implementation Intentions strategy to reduce salt intake among Hypertensive people in Primary Care Clincs	Data analysis completed	Intervention	2018-04-03	<NULL>	<NULL>	1696	Implementation Intentions strategy as a nursing intervention to reduce salt intake among hypertensive patients in primary care practice: evaluation of the effectiveness in real practice	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Faculdade de Enfermagem, Universidade Estadual de Campinas	CAPES, Programa de Doutorado Sanduíche no Exterior	https://ensaiosclinicos.gov.br/rg/RBR-4wg3g3	<NULL>	The inclusion criteria for nurses were: be a registered nurse, emplyer of the municipality; nurses who have been working in the PHCs for at least 6 months. The inclusion criteria for patients were: aged 18 years or over; medical diagnosis of hypertension described in their medical records. The inclusion criteria for social referents were: couples, daughters or sons, parents or pther person responsible for meals preparation for the patient; aged 18 years or over; with availability of attending the health service as patients companion in all phases of the research.	Nurses in long licence of work (more than four months) were excluded. Patients were excluded if they had no verbal conditions of communication; they had mental disorders described in the medical records; there was no possibility of the social referent follow the patient in the nursing consultations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-3vz3nd	Effects of Hatha-Yoga on caregivers of children and adolescents with Cancer	Data analysis completed	Intervention	2018-04-10	<NULL>	<NULL>	1702	Effects of Hatha-Yoga intervention on caregivers of children and adolescents with Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-29	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Hospital Infantil Nossa Senhora da Glória	https://ensaiosclinicos.gov.br/rg/RBR-3vz3nd	<NULL>	Accompanying children and adolescents admitted to HINSG as new cases of cancer; minimum attendance period of 40 weekly hours; absence of prior contact with yoga, meditation or related techniques.	"Volunteers who did not agree to participate in the study or who showed interest were very resistant to being absent from their caregivers, or even if they presented psychic limitation to answer the questions of the initial interview. Cases of hospitalization or deaths in a very short period precluding the invitation to participate in the study; hospitalizations with advanced and irreversible impairment of the patient&apos;s clinical condition, that is, in palliative care; and the cases of prior knowledge of the volunteer about the diagnosis of the assisted.
In the cases of relay of caregivers in care of the same child or adolescent only the participation of a volunteer was allowed, whose choice to participate in the study was based on the above criteria. When caretakers in relay were able to participate in the study a draw was held between them. However, hospitalizations of children or adolescents with many caregivers in relay with uncertainty of a regular return to care were excluded from the study, configuring the non-inclusion of the volunteer during the study period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-2f8xhc	Evaluation of inflammation in patients undergoing to surgery under anesthesia with desflurane or desflurane associated with nitrous oxide	Data analysis completed	Intervention	2016-11-17	<NULL>	<NULL>	1703	Comparison of inflammatory markers in surgical patients under anesthesia with desflurane or desflurane associated with nitrous oxide	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-2f8xhc	<NULL>	Healthy individual;both sexes; aged between 18 and 50 years; who do not present other disease unless the operative condition; undergoing otorhinolaryngologic elective surgery; lasting at least 90 minutes	Smoking; using illicit drugs and alcohol; users of daily vitamin supplements and / or antipyretics; analgesics; antibiotics; anti-inflammatory; among others; the occupationally exposed to paints; fuel; pesticides and hospital environments; those who received radiation ionizing or MRI done in less than 30 days; those who have already undergone chemotherapy or radiotherapy; patients with diseases such as asthma, hypertension; diabetes; cancer; infectious or inflammatory processes; and those who are not referred for surgery of ENT and ophthalmology clinic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-92j6qf	Early mobilization of patients hospitalized in the intensive care unit	Data analysis completed	Intervention	2018-04-11	<NULL>	<NULL>	1705	Early mobilization of critically ill patients - randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-92j6qf	<NULL>	Patients with at least 24 hours of admission to the Intensive Care Unit, with or without sedation; older than 18 years old; both genders; presenting significant hemodynamic stability considered as the absence of hypotension or vasopressóricas need for drugs at lower doses less than 1mcg/hora/kg noradrenaline; absence of neuromuscular, oncological, neurological diseases or traumotortopédicas including amputation) prior or recent surgeries; have normal functional ambulation, use of assistive device accepting gait; accepted to participate in the certificate states the responsibility for the patient when they had not been enough awareness for decision making.	Hospitalization prior period with less than thirty days prior to the date of admission to HRTN; Patients transferred from other hospitals to CTI CTI&apos;s HRTN; Patient aware that refused to participate in any of the two groups after randomization; Refusal of the patient to participate in this study after recovering state of consciousness suited to making decisions when your entry is made by authorization of family and / or guardian; Patients who require cardiopulmonary resuscitation during the ICU stay; Patients who had a change in diagnosis as stroke as a cause of ICU stay current.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-277fqv	Effects of Video Game Games on Breathing and Balance of Parkinson&apos;s patients	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	1710	Effects of Physical Training with Exergames on the Respiratory Function and on the Balance of Individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-277fqv	<NULL>	Subjects with moderate stages of Parkinson&apos;s disease; both genders; autonomy to perform the exercises; identified through the Mini Mental Status Examination	The smokers; who presented an uncorrected visual deficit; associated respiratory, cardiac or neurological disease; who had changes in Parkinson&apos;s disease medication (dopaminergic) during the study; three consecutive days of physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4jggg5	Intervention for children with nighttime fears and who do not sleep alone	Data analysis completed	Intervention	2017-01-18	<NULL>	<NULL>	1712	Intervention for preschool children with nighttime fears and avoidance behaviors of sleeping	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-20	Instituto de Psicologia da Universidade de São Paulo	Renatha El Rafihi Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-4jggg5	<NULL>	Children aged four to six years; both genders; Who present intense nighttime fears accompanied by avoiding sleep behavior alone or meeting criteria for the diagnosis of separation anxiety disorder or specific phobia of sleeping alone / dark based on the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V, 2013), or for separation anxiety by the Preschool Anxiety Scale (PAS), or clinic for anxiety subscale by the Children Behavior Checklist  (CBCL-1½ and 5 years).Children who have one or more behavioral problems related to sleep, as follows. Reluctance or inability to go to bed without arguing, crying, complaining, or otherwise delaying bedtime; Reluctance or inability to fall asleep alone without being close to an attachment figure; Reluctance or inability to sleep all night in your own bed without calling your parents or going to bed at night; The problem has occurred for at least six months with an adverse impact on the child and the family, requiring parental intervention for at least two nights a week to comfort the child, impairing the quality of sleep; Availability of at least one parent participating in the intervention program.	Children with neurological impairment, psychotic symptoms or concomitant treatment for nighttime fears; Parents who are not literate or unable to read.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4xqq6n	Physiotherapy in Hemodialysis patients: Effect of Exercise on Physical Ability, Quality of Life and Depression	Data analysis completed	Intervention	2018-04-16	<NULL>	<NULL>	1713	Physiotherapy in Patients with Chronic Renal Failure: Effect of Resistance Exercise on Functional Capacity, Quality of Life and Depression	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-4xqq6n	<NULL>	Age between 18 and 60 years; Both sexes; In hemodialysis treatment between 1 and 6 years; Sedentary; Non smoker.	Patients who refuse to sign the informed consent form (EFT); Carriers of hepatitis B and C, HIV and tuberculosis; Patients with a history of myocardial ischemia for less than 6 months; Patients with motor or cognitive deficits that make it difficult to perform the 6MWT, manovacuometry, spirometry, dynamometry and response to KDQOL-SFTM or the BDI scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9329z8	Reduction of Anxiety Symptoms and Promotion of Social and Emotional Skills in Preschool Children	Data analysis completed	Intervention	2018-04-17	<NULL>	<NULL>	1718	Prevention of Anxiety and Promotion of Social-Emotional Skills in preschool children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9329z8	<NULL>	age between 4 and 7 years; both genders; parental permission	Mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-2kbs8k	Blood pressure response after combination of natural foods and exercise	Data analysis completed	Intervention	2018-04-18	<NULL>	<NULL>	1721	Influence of food and nutritional supplements on exercise-induced hypotension in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-08	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2kbs8k	<NULL>	Hypertensive; sedentary; non-diabetic	Use beta-blockers and calcium channel blockers; Do not participate in at least one of the four experimental procedures; Modify your eating habits during the study period; Do not follow the nutritional recommendations of the days prior to the experimental procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9rh8vr	Impacts of neurosurgery on non-motor symptoms in Parkinson&apos;s Disease patients.	Data analysis completed	Observational	2018-04-18	<NULL>	<NULL>	1725	Impacts of staged bilateral pallidotomy or campotomy on non-motor symptoms in Parkinson&apos;s disease.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-11-01	Hospital Santa Marcelina	Hospital Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-9rh8vr	<NULL>	"Patients with Idiopathic Parkinson&apos;s Disease; clinical Indication for neurosurgical treatment for Parkinson&apos;s disease; 
Age greater than 18 Years; 
Stage two or greater on Hoehn and Yahr Scale in the absence of medication.  
Presence of significant motor dysfunction during three or more hours per day despite receiving adequate drug treatment; 
Persistence of motor dysfunction under revised and adequated medication regimen for at least 1 month; 
Consent to participate in the defined evaluations; Consent to perform surgical procedure with the purpose of treating Parkinson&apos;s symptoms; 
Patients who sign the Informed Consent Form according to the Norms of the Research Ethics Committee of Santa Marcelina Hospital."	"Patients with parkinsonism associated with another degenerative disease such as Multi-systemic Atrophy; Dementia by Lewy Bodies; Alzheimer&apos;s disease; Cortico-Basal degeneration; Fronto-temporal dementia; cerebellar ataxia. Patients with suspected secondary parkinsonism such as cerebral vascular disease; Use of medications; Normal pressure hydrocephalus; Traumatic brain injury. Patients with previous surgical treatment for Parkinson&apos;s Disease as pallidotomy; talamotomy or electrode Implant for deep brain stimulation. Patients with clinical or cardiologic contraindications to perform the surgical procedure. Current use of neuroleptic drugs for the treatment of behavior disorders or hallucinations associated with the use of dopaminergic drugs. Patients with schooling Level very Low (below 2 Years) or with auditory or visual deficiency, in such a way as to Inviabilize neuropsychological evaluation. Personal history of alcohol abuse.
Diagnosis of current severe depression, according to DSM-IV criteria - American Psychiatric Association 2000. Patients with dementia diagnosis associated with Parkinson&apos;s disease according to the criteria stablished by the movement disorders society."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4w9pkt	Number of academy gymnasts suffering from overtraining syndrome in the city of Joao Pessoa	Data analysis completed	Observational	2018-04-24	<NULL>	<NULL>	1730	Prevalence of overreaching and overtraining in gymnastics teachers of the city of João Pessoa	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-12-17	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4w9pkt	<NULL>	Have been giving gym classes for at least two years; ministering and practicing at least 15 lessons per week; at least six months since the last vacation; seemingly healthy and free of muscle-tendon injuries in the last 30 days	Have some type of injury that affects your locomotion; have some type of chronic-degenerative disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-4rw55d	Clinical Evaluation of Adhesives for Restoration of cavities in the Cervix of the Teeth not Caused by Caries	Data analysis completed	Intervention	2018-04-27	<NULL>	<NULL>	1733	Randomized Clinical Evaluation of Simplified Adhesive Systems in Non-Carious Cervical Lesions: Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-10	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4rw55d	<NULL>	"Being in good general health; Be over 18 years of age; Have an acceptable level of oral hygiene; To present at least 20 teeth under occlusion; To have at least 4 non-carious lesions on different teeth to be restored.
The lesions should be non-carious, non-retentive, with a depth greater than 1mm, and enamel and dentin envelopment of vital teeth without mobility; The cavo-superficial margin can not involve 50% more enamel."	Patients with extremely poor oral hygiene; Cronic or severe periodontitis; Severe parafunctional habits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-4sty47	The influence that physical exercise Tai-Geiko provides in people with multiple sclerosis regarding muscle strength, balance and performing two tasks at the same time.	Data analysis completed	Intervention	2018-04-29	<NULL>	<NULL>	1736	The influence of Tai-Geiko on the physical and functional aspects of patients/peoples  with multiple sclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-13	Faculdade de Educação Física da Universidade Federal de Mato Grosso	Faculdade de Educação Física da Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-4sty47	<NULL>	"Medical diagnosis of multiple sclerosis for two years;
Undergoing treatment with medical follow-up;
Obtain Expanded Disability Status Scale EDSS score of less than 6.0;
Do not have medical diagnosis of diseases secondary to Multiple Sclerosis as: physical and / or mental deficiencies; heart diseases; Dyslipidemias; And Diabetes Mellitus;"	"Not being in medical follow-up
Failing to perform the physical tests."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-8r4jpg	Effects of protein supplementation in nutritional status of hemodialysis patients	Data analysis completed	Intervention	2018-04-29	<NULL>	<NULL>	1737	Effects of oral supplementation with albumin in nutritional status of hemodialysis patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Nutrição da Universidade Federal de Goiás	Centro de Nefrologia - Centrel	https://ensaiosclinicos.gov.br/rg/RBR-8r4jpg	<NULL>	The inclusion criteria adopted for participation in the study were: patients of both sexes, aged between 20 and 79 years, for at least three months on hemodialysis treatment, performing three sessions per week.	The exclusion criteria were: bedridden patients; Amputees; Patients with decompensated diabetes; Pregnant women; Who are consuming nutritional supplements containing protein; Food intolerance or allergy to egg white protein; Liver disease, intestinal malabsorption, cancer and Acquired Immunodeficiency Syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-53fx6p	Effects of Physical Exercise on Cognitive and Motor Functions in Alzheimer&apos;s Disease	Data analysis completed	Intervention	2018-04-30	<NULL>	<NULL>	1742	Exercise, Biomarkers and Functionality in Alzheimer&apos;s Disease and in Frailty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-03	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-53fx6p	<NULL>	Elderly with clinical diagnosis of Alzheimer&apos;s disease, according to the Diagnostic and Statistical Manual of Mental Disorders; Severity of mild and moderate dementia according to the Dementia Clinical Assessment Score; Availability for participation of the evaluations proposed by the researcher; Elderly persons and their respective caregivers who agree to the study procedures and who agree to sign the Informed Consent Form.	"Elderly patients with coronary heart disease, cardiac arrhythmias, uncontrolled hypertension and angina symptoms, or who have any absolute restriction on physical exercise; Elderly people with visual, auditory, dizzying or other impairments that impair locomotion and balance;
Elderly with other neuropsychiatric conditions;
Frequency less than 70% in the program."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9d48pk	Evaluation of TCD-10023 stent in patients with acute myocardial infarction. MASTER study T120E4	Data analysis completed	Intervention	2015-03-17	<NULL>	<NULL>	1747	Safety and efficacy of TCD-10023 drug-eluting stent in management of patients with acute ST-elevation myocardial infarction. MASTER study T120E4	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-15	Instituto Dante Pazzanese de Cardiologia	Real e Benemérita Associação Portuguesa de Beneficência	https://ensaiosclinicos.gov.br/rg/RBR-9d48pk	<NULL>	Age equal or more than 18 years; Chest pain &gt; 20 minutes; Primary PCI &lt;24h from symptoms onset; ST-segment elevation of &gt; 1 mm in &gt; 2 contiguous leads, or (presumably new) left bundle branch block, or true posterior MI with ST depression of &gt; 1 mm in &gt; 2 contiguous anterior leads; Presence of at least one acute infarct artery target vessel with one or more coronary artery stenoses in a native coronary artery from 2.5-4.0 mm in diameter that can be covered with one or multiple stents; Signed informed consent	Female of childbearing potential (age &lt; 50 and last menstruation within the last 12 months), who did not underwent tubal ligation, ovariectomy or hysterectomy; Known intolerance to aspirin, clopidogrel, heparin, bivalirudin, cobalt, chromium, nickel, sirolimus or contrast material; Currently participating in another trial before reaching primary endpoint; Mechanical complication of acute myocardial infarction (e.g. cardiogenic shock…); Acute myocardial infarction secondary to stent thrombosis; Previously stented infarction related artery (IRA); Planned surgery within 6 months of PCI unless dual antiplatelet therapy is maintained throughout the peri-surgical period; Patients with non-cardiac comorbid conditions with life expectancy &lt; 1 year or that may result in protocol non-compliance; History of bleeding diathesis or known coagulopathy; Use of oral anticoagulants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-6r7ww5	Effect of muscle endurance training in elementary public school teachers	Data analysis completed	Intervention	2012-02-29	<NULL>	<NULL>	1749	The chronic effect of stretching taken before or after exercise for hamstrings on musculoskeletal symptoms in a group of public school teachers of Matinhos-PR	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-25	Universidade Federal do Paraná Setor Litoral	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6r7ww5	<NULL>	"Effective municipal elementary school teachers, working in classrooms, directly with the students;
General health condition;
Sedentarysm for at least eight weeks."	"Teachers retired; 
Current pathology or early that prevented evaluations and/or exercises; 
Participated in other programs that included physical exercises and evaluations that were incomplete data."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-72dsyv	Nursing care planned with a computer program for the comfort of people with cardiovascular diseases	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	1756	Computerization of the nursing process: a technology for the clinical care of the comfort of people with cardiovascular disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-04	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-72dsyv	<NULL>	Age equal to or greater than 18 years; medical diagnosis of cardiovascular disease; accompanied in the home modality	Difficulty in speech; cognitive deficit that hinder communication; reside in an area of extreme urban violence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-5kqsnp	Addition of blood flow restriction to passive mobilization reduces hypotrophy rate in Elderly Intensive Care Unit patients: A within patient randomized trial	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	1763	Addition of Peripheral Blood Flow Restriction to Passive Mobilization in muscle atrophy in ICU patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Sociedade Pelotense de Assistência e Cultura(SPAC)	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5kqsnp	<NULL>	The inclusion criterion was admitted to the ICU sector of two reference hospitals in Belém, from September to October 2017, and to be admitted to the PM protocol, with the following parameters: Pa02 / Fi02&gt; 300, oxygen saturation (BP) &lt;140 bpm, systolic blood pressure (SBP) 90-180 mmHg, arterial blood pressure (BP) &lt;60 bpm, arterial blood pressure (PaO2)&gt; 90% diastolic (DBP) 50-120 mmHg, respiratory rate of up to 30 breaths per minute and absence of uncontrolled ECG arrhythmias.	Death or do not complete intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-7k4ttg	Effects of levodopa on masticatory and oral sensory function in Parkinson’s Disease	Data analysis completed	Observational	2018-05-10	<NULL>	<NULL>	1777	Oral health and chewing function in patients with Parkinson’s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-10	Faculdade de Odontologia de Piracicaba	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7k4ttg	<NULL>	"Case group: volunteer with Parkinson&apos;s disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses.
Control group: Paired study"	"Case group: volunteers should not have neurodegenerative disease, except for Parkinson&apos;s disease; and should not have not neurological disorders in which parkinsonism comprises the clinical condition.
Control group: Paired study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-2vzd48	Development and application of a Phosphorus Counting Table for control of blood level of phosphorus in patients with Bone Disease in hemodialysis	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1794	Characterization and application of a Phosphorus Counting Table for control of hyperphosphatemia in patients with Bone Mineral Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-09	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2vzd48	<NULL>	Patients with chronic kidney disease and disease–mineral and bone disorder in hemodialysis; age range greater than or equal to 18 years; literate or had literate carer; serum phosphorus levels less than or equal to 7,8mg/dL after thirty days of phosphate binder cessation; sign the written informed consent form	Patients in use of anti-inflammatory hormones; patients with neoplasias or active infectious diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-83j396	Comparison of brain connections post open-surgery or carotid angioplasty through functional Magnetic Resonance Imaging	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1796	Brain connections analysis post Endarterectomy versus Stent carotid Angioplasty by functional Magnetic Resonance in rest state	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-23	Instituto de Neurologia e Neurocirurgia de Passo Fundo	União Brasileira de Educação e Assistencia	https://ensaiosclinicos.gov.br/rg/RBR-83j396	<NULL>	Patients 18 years old or older; with carotid stenosis above 60% asymptomatic; or patients who had a transient ischemic attack (TIA) with carotid stenosis above 50%; or ulcerated plaque;  who agree to participate in the study	Patients with severe neurological disease such as parkinsonism, dementia, epilepsy, defined cerebrovascular disease, encephalopathy, severe depression; Patients who use drugs that directly affect the central nervous system, which prevent individualized natural responses to the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-8chg6q	Effects of muscle stretching on pain	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1797	An exercise program for Postural Correction and Pain symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8chg6q	<NULL>	Nursing professional; officer of a polyclinic in the city of niterói-rj; ages between 18 and 60 years; to present some postural deviation; do not practice any physical activity oriented during the period of participation in the research	Inability to perform tests and stretching exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7mry33	Surgical aperture for irrigation of the bowel in children with Constipation	Data analysis completed	Intervention	2018-05-15	<NULL>	<NULL>	1798	Appendicostomy for the Anterograde Enema in children with Refractory Constipation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-10	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7mry33	<NULL>	Patients on follow-up in a tertiary medical care service diagnosed as refractory constipation	Patients who do not fill the diagnosis of refractory constipation criteria that is: persistence of retentive incontinence for at least 12 months on maximum tolerable doses of oral laxatives and rectal enemas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-4cpbr5	Effects of diamond peeling on spots in the female inguinal region	Data analysis completed	Intervention	2018-05-16	<NULL>	<NULL>	1804	Effects of diamond peeling on hyperchromic spots and folliculitis in the female inguinal region	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-09	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4cpbr5	<NULL>	Women older than 18 years; presence of hyperchromic spots in the inguinal region; literate; able to respond to research questionnaires	"Women who were in dermatologicalfunctional treatment to improve the hyperchromic spots of the inguinal region; predisposition to keloids; tissue lesions and infectious skin disease; presence of hormonal, cardiac, respiratory diseases, diabetes mellitus, systemic arterial hypertension and neoplasms;
inability to provide sensitive feedback or with changes in cutaneous sensitivity; not to attend three consecutive days of treatment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-7qhv4f	Evaluation of bone loss around implants with Morse cone connection	Data analysis completed	Intervention	2018-05-17	<NULL>	<NULL>	1808	Biomechanical analysis of hybrid titanium-based abutments in Morse taper implant connection	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-26	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7qhv4f	<NULL>	Sufficient bone dimensions to install an implant with a Morse cone-type implant of at least 3.5 mm in diameter and 8 mm in height; Satisfactory oral hygiene	Patients with systemic diseases that compromise the technique. With severe maxillomandibular discrepancies. With severe parafunctional habits. Drug users, alcohol or smoking abuse (greater than 10 cigarettes / day). With coagulant or anticoagulant therapy. Immunosuppressed and / or irradiated. With oral disease requiring prior treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-5dsrhv	Comparation of treatments of temporomandibular joint problems	Data analysis completed	Intervention	2018-05-18	<NULL>	<NULL>	1814	Comparative study of temporomandibular disfunction therapies: randomized blind controled clinical trials	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Odontologia da Universidade Federal do Ceará	Faculdade de Odontologia da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5dsrhv	<NULL>	Female gender; age between 18 and 59 years; diagnosis temporomandibular dysfunction; adequate bilateral occlusal contacts between molars and premolars; history of orofacial pain, at least during the last 6 months; absence of previous treatment for pain; pain intensity equal to or greater than 7 on a visual analogue scale from 0 to 10; good receptivity and understanding of spoken Portuguese; ability to provide free and informed consent; and availability for attendance to evaluation returns	Abuse of alcohol or illicit drugs; use of antidepressant or antipsychotic medications in the three months prior to the survey; hypersensitivity to the drugs proposed in the research; history of rheumatic or vascular disease; neurological disorders or any systemic base disorders; patients with motor or mental disorders; pregnant women, and patients who suffered some type of macro or microtrauma on the face	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-3zvgwb	Study of Solutions of Darkened Color during the Bleaching Treatment with two types of gels, regarding Color Change and Dental Properties	Data analysis completed	Intervention	2018-05-19	<NULL>	<NULL>	1815	Influence of Staining Solutions used during Dental Bleaching with high and low concentrations of Peroxides on color change and Enamel Surface Properties	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Faculdade São Leopoldo Mandic	Fundação de Amparo a Pesquisa no Estado de São Paulo-FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-3zvgwb	<NULL>	"Healthy patients between ages 18 and 30 years who have at least 24 teeth.
Female or male"	People wearing dentures or fixed/removable orthodontic appliances; Pregnant or lactanting women; smokers; Patients who take medication that can cause salivary flow reduction (antihypertensives, anticonvulsants, for example).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-358sm6	Electrical stimulation in individuals with difficulty coordinating body movements	Data analysis completed	Intervention	2018-05-21	<NULL>	<NULL>	1820	Transcranial direct current stimulation in individuals with Cerebellar Ataxia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-01	Faculdade de Medicina da Bahia	Faculdade de Medicina da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-358sm6	<NULL>	Individuals with non-progressive or slowly progressive cerebellar ataxia; literate; independent gait; magnetic resonance imaging of the brain showing diffuse cerebellar atrophy	Individuals with treatable cerebellar ataxia or other associated diseases; intellectual deficit; brain malformations; severe visual or auditory deficits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-7nbnpc	Effects of photobiomodulation therapy applied immediately before resistance training in type 2 diabetic women	Data analysis completed	Intervention	2018-05-21	<NULL>	<NULL>	1827	Low-Power Laser Effects Applied to Resistant Pre-Training in Old Type 2 Diabetics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-05	Associação Educacional Nove de Julho	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7nbnpc	<NULL>	Women aged 60 to 79 years were included; diagnosis of Type 2 Diabetes Mellitus for at least 1 year; cognitive score greater than 18 in Minimental; glycated hemoglobin above 6.5%; casual blood glucose up to 250 mg / dl; body mass index up to 40kg / m2; make use of insulin only as supplementation of glycemic control; normal or controlled systemic blood pressure with medication; released by the doctor to physical exercise	As voluntárias foram excluídas se realizassem exercícios físicos regulares ou fisioterapia motora; na presença de alterações auditivas; visuais e/ou motoras severas; ou ainda qualquer situação de saúde que impedissem a aplicação dos instrumentos avaliativos e a execução da intervenção proposta. Foram excluídas ainda se tivessem 2 faltas consecutivas ou 3 faltas alternadas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-22kxyc	Results of a program involving adequacy of wheelchair posture in the quality of life, satisfaction and activities of caregivers of children with cerebral palsy	Data analysis completed	Intervention	2018-05-22	<NULL>	<NULL>	1832	Effects of postural adequacy on satisfaction, quality of life and occupations of caregivers of children with cerebral palsy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-02	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-22kxyc	<NULL>	Caregivers who accompany adolescents with clinical diagnosis of cerebral palsy for at least one year and who do not receive remuneration for care; adolescents who are aged between 10 and 19 years and who use wheelchairs in a home environment for at least one year.	Adolescents with cerebral palsy who have already undergone postural adjustments through the use of the digitized system; who are able to use the wheelchair independently, requiring no direct assistance from a caregiver.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8v7qhq	Effect of functional foods on Metabolic Syndrome	Data analysis completed	Intervention	2018-05-22	<NULL>	<NULL>	1834	Effect of nutraceuticals on Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Universidade Federal do Estado do Rio de Janeiro	Escola Nacional de Saúde Pública/FioCruz	https://ensaiosclinicos.gov.br/rg/RBR-8v7qhq	<NULL>	Subjects aged 18 or older; carrying Metabolic Syndrome criteria according to the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP ATPIII 2001); who consented formally to join the study	Those who had diagnostic for thyroid abnormalities; hepatic ou renal failure; under treatment for corticoids; hipolipemiant drugs or low calorie diet on the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8ysb3n	Evaluation of the Physiotherapy with Cycle Ergometer in the Funcional Recovery after Cardiac Surgery	Data analysis completed	Intervention	2018-05-22	<NULL>	<NULL>	1835	Cycle Ergometer and Conventional Physiotherapy in patients submitted the Cardiac Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-31	Hospital Santa Izabel - Santa Casa de Misericórdia da Bahia	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-8ysb3n	<NULL>	Patients of both sexes; aged 18 or older; admitted to the ICU and underwent coronary artery bypass graft surgery and / or valve replacement.	Patients with change of the level of consciousness; motor- or neurological impairment; with persistent hemodynamic instability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-9zqwhv	Psychological problems and hand function in children and adolescents with kidney disease undergoing Hemodialysis treatment	Data analysis completed	Observational	2018-05-22	<NULL>	<NULL>	1837	Psychological and functional alterations in adolescents with Chronic Renal Disease dependent on hemodialysis in initial and advanced treatment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9zqwhv	<NULL>	"Children and adolescents aged 9 to 19 years, the control group was paired with respect to gender and age;
For the sample, children and adolescents diagnosed with CKD, and dependent on hemodialysis treatment;
Signature of the Informed Consent Term (TCLE) and the Informed Consent Term (TALE), both for the group of patients and for the control group;"	"Children and adolescents with inability to understand the objectives of the study, as well as the issues presented;
Severe auditory or verbal impairment, making it impossible to understand the tests and objectives of the study;
Medical contraindication for participation;
Severe neuropsychiatric comorbidity associated."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-78zr5h	The effect of Educational Intervention on self-care of the elderly with Diabetes	Data analysis completed	Intervention	2018-05-29	<NULL>	<NULL>	1857	Effect of Educational Intervention to foot self-care of the elderly with Diabetes Mellitus	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-08	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-78zr5h	<NULL>	Minimum age of sixty years; diagnosis of Diabetes Mellitus; Being monitored at the basic health unit.	Impossibility to walk to the health unit; impairment of speech and vision.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-4chsdr	Study of aquatic physiotherapy in women after surgery for breast cancer	Data analysis completed	Intervention	2018-05-30	<NULL>	<NULL>	1858	Evaluation of the performance, efficacy and safety of aquatic physiotherapy in the rehabilitation of shoulder movements in women submitted to surgical treatment of breast cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Brazilian Mastology Research Network	Brazilian Mastology Research Network	https://ensaiosclinicos.gov.br/rg/RBR-4chsdr	<NULL>	"Females were included between the 7th and 20th postoperative days of mastectomy or quadrantectomy associated with axillary lymphadenectomy at levels I, II and III of Berg; 
who were regularly followed up at the services proposed for the study."	The exclusion criteria were: to present lymphedema in the homolateral upper limb before and/or after surgery, open wounds and presence of infection at the surgery site, presence of drains and/or probes, as well as clinical pathologies in activity, such as heart failure, visual impairment, and faecal or urinary incontinence. Also excluded were women with orthopedic changes in the shoulder joint, such as impact syndrome and rotator cuff tendinopathy. Exclusion criteria related to breast cancer included metastatic disease, sentinel lymph node biopsy, immediate post-mastectomy breast reconstruction, and peitoral muscle resection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-248x3v	Physical Activity and Sleep Hygiene as a treatment of Depression in the elderly	Data analysis completed	Intervention	2018-05-30	<NULL>	<NULL>	1859	Physical Activity and Sleep Hygiene: frequently neglected aspects in the treatment of Depression in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-10	Universidade Federal de Minas Gerais	Ambulatório de Neuropsiquiatria Geriátrica, Hospital Borges da Costa, Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-248x3v	<NULL>	Age above 60 years; both sexes; under medication treatment of the depressive disorder; complaints of sleep disorders.	Hemodynamic instability; severe cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-94dhdy	Association of a Phosphorus Counting Table with Sevelamer for control of blood level of phosphorus in hemodialysis patients	Data analysis completed	Intervention	2018-05-31	<NULL>	<NULL>	1864	Association of a Phosphorus Counting Table with Sevelamer Hydrochloride for control of hyperphosphatemia in hemodialysis patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-03	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94dhdy	<NULL>	Patients on hemodialysis for at least 6 months and who underwent a dialysis regimen at three times a week with a duration of four hours per session; age range greater than or equal to 18 years; literate or had literate carer; phosphate binder use for at least 12 weeks; parathyroid hormone less than 800pg/mL; signed the written informed consent form	Patients who missed more than one hemodialysis session per month; patients in use of anti-inflammatory hormones; patients with neoplasias or active infectious diseases; patients with indication of use of calcium carbonate as phosphate binder and who had no indication of sevelamer hydrochloride use; hypophosphatemic patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-4pdpjm	Treatment of varicose veins with laser and radio frequency - comparative study.	Data analysis completed	Intervention	2018-06-06	<NULL>	<NULL>	1876	Endovenous Treatment of saphenous Insufficiency - a comparative study between Radiofrequency and Endolaser 1470 nm	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4pdpjm	<NULL>	Patients older than 18 years; with symptomatic venous disease of the lower limbs; with bilateral great saphenous vein reflux.	Patients without clinical conditions to be submitted to the proposed treatment; on the use of anticoagulants or with a diagnosis of coagulation disorder; carriers of chronic or acute inflammatory disease; history of neoplasia; age greater than 70 years; women who are pregnant or intending to become pregnant; women in lactation; presence of signs of peripheral obstructive arterial disease (ankle-arm index&gt; 0.9); history of prior varicose vein surgery; presence of significant reflux in the external saphenous vein or perforating vein, by the DUS evaluation; presence of reflux in the deep venous system, signs of superficial thrombophlebitis and recent or old thrombosis in the deep venous system, by the DUS evaluation; with lymphedema.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-9z6hx2	Clinical Assessment of Caries Restorations in the posterior tooth with bulk-fill resin	Data analysis completed	Intervention	2018-06-06	<NULL>	<NULL>	1879	Longitudinal Clinical Assessment of Class II Cavity Restorations Using Bulk-Fill Technique: A Randomized Clinical  Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9z6hx2	<NULL>	Necessity of two Class II restorations with composite resin for decayed teeth or the necessity of changing the restoration; teeth which can be fully isolated; presence of antagonist and adjacent tooth; and teeth with vital pulp; no pain; direct pulp capping and no history of hypersensitivity	Very extensive caries lesion; pulp exposure during caries removal or cavities with a high risk of exposure; allergies to the materials to be used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-573pcm	Effects of training the muscles of inspiration and training the muscles of the center of the body in professional athletes	Data analysis completed	Intervention	2018-06-07	<NULL>	<NULL>	1880	"Effects of inspiratory muscle training and
core training in professional athletes"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-10	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-573pcm	<NULL>	Males; Being an athlete at competitive level for at least one year; Having aged 18 to 35 years	Use of medications that interfere on autonomic control;respiratory diseases;cardiovascular diseases; smoking;sports injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8y748j	The Sleep of wheelchair rugby athletes: Train, rest and competition	Data analysis completed	Observational	2018-06-14	<NULL>	<NULL>	1895	Perception analysis of sleep and its relationship with performance in athletes of wheelchair rugby, during different phases of training	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-02-20	Unversidade Estadual de Campinas	Universidade federal de minas gerais	https://ensaiosclinicos.gov.br/rg/RBR-8y748j	<NULL>	Wheelchair rugby athletes from the same team, they must have been enrolled in regional, national or international competitions	The atheletes must wear the actigraphy for seven consecutive days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-24tf9n	Direct current neuromodulation and its benefits in different populations	Data analysis completed	Intervention	2018-06-15	<NULL>	<NULL>	1902	Transcranial direct current stimulation and the  potential therapeutic approach in different populations	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-24tf9n	<NULL>	Participants were selected from a specialized outpatient service and regarded as suitable to participate in this study if they fulfilled the following criteria: clinical diagnoses of diabetic polyneuropathy; aged from 18 to 60 years; not lactating; no history of brain surgery, tumor, or intracranial metal implantation	Participants with any uncontrolled clinical disease, such as thyroid disease, cardiovascular, pulmonary, haematological or renal disease; alcohol or other substance abuse; pregnancy; lactation; neuropsychiatric disorders; history of epilepsy and metallic implants in the head were excluded. Patients with significant cognitive dysfunction were excluded. Patients were carefully evaluated by a physician	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-555xm5	Perioperative use of pregabaline in mastectomies	Data analysis completed	Intervention	2018-06-15	<NULL>	<NULL>	1903	Pregabaline as attenuator of Acute and Chronic Post-Operative Pain in mastectomies	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-09	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-555xm5	<NULL>	Women&apos;s volunteers; scheduled for mastectomies; between 20 and 65 years; ASA II and III; without renal and hepatic comorbidities.	Women&apos;s Volunteers; scheduled for mastectomies; with hepatic and / or renal comorbidities; with BMI greater than 40; with low cognitive degree; not agreeing to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-56qkdc	Quality of care among people living with HIV/AIDS in Manaus and its influence on timely treatment initiation and adherence to antiretroviral therapy	Data analysis completed	Observational	2018-06-15	<NULL>	<NULL>	1904	Research on the quality of care among people living with HIV/AIDS in Manaus and its influence on timely treatment initiation and adherence to antiretroviral therapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-09-19	Fundação de Medicina Tropical do Amazonas - FMT/IMT/AM	Manaus, LLC	https://ensaiosclinicos.gov.br/rg/RBR-56qkdc	<NULL>	The study participants were: People living with HIV/AIDS (PLHA) 18 years old or older; PLHA who received healthcare services at FMT or the four SAEs; and PLHA who had had at least one visit at any of these health centers.	The study did not interview patients who were visiting the health center for the first time at the time of the interview. The reason for excluding these new users is that patient satisfaction questions corresponded to the last consultation, which would be irrelevant to patients who were visiting the health center for the first time. The study also excluded patients younger than 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-8dmfjf	Effectiveness of Acupuncture on Pain in the emergency room	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	1910	Evaluation of effects of Acupuncture in Pain in the emergency room	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-02	Instituto de Assistencia Medica do Servidor Publico Estadual	Instituto de Assistencia Medica do Servidor Publico Estadual	https://ensaiosclinicos.gov.br/rg/RBR-8dmfjf	<NULL>	older than 18 year-old; neck pain; back pain; low back pain; hip pain; shoulder pain; elbow pain; wrist pain; knee pain; ankle pain; pain in the hands or feet; carpal tunnel syndrome or fibromyalgia	severe psychiatric disorders; chest pain; suspected fractures; requiring emergency care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-892vvp	Electrical current during gait training in people after Stroke	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	1911	Functional Electrical Stimulation during gait training in people post-Stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-22	Associação Prudentina de Educação e Cultura Apec	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-892vvp	<NULL>	Sequel of Stroke with motor conditions of training; consent of the individuals with the due signature of the consent term.	Peripheral nerve damage in lower limbs; osteo-articular deformities; cognitive and visual deficits that interfered in the understanding and execution of the proposed training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-2z2cjs	Evaluation of the effectiveness and sensitivity after tooth bleaching	Data analysis completed	Intervention	2018-06-19	<NULL>	<NULL>	1912	Effectiveness and sensitivity after bleaching gels carbamide peroxide based	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-03	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2z2cjs	<NULL>	Patients with all superior anterior teeth and with restorations in a maximum of 1/6 of the vestibular surface of each element; Be over 18 years of age; Good general and oral health conditions; Sign the free and informed consent form; Possibility of attending all sessions for research control; Had no professional prophylaxis during the study period	History of any medical disease that may interfere with the study or require special considerations such as diabetes and / or presence of pathology in the oral cavity (excluding caries); Be a smoker and / or have used tobacco in the last 30 days; Have used home and / or office bleaching agents in the last year; Gingival index score greater than 1.0; Pregnant or lactating women; Teeth stained by Tetracycline	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-989h4f	Clinical evaluation of restorations of posterior teeth using different types of composite resins	Data analysis completed	Intervention	2018-06-19	<NULL>	<NULL>	1914	Evaluation of admira fusion vs admira fusion xtra resins in posterior teeth restorations: randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-989h4f	<NULL>	Presence of cavities, fractures or cosmetic demands; first or second molars and permanent premolars needing restorations; should be performed at least two Class II restorations in each patient (the number of restorations of each material should be equal in each patient); presence of the antagonist and the adjacent tooth making contact; pulp vitalized and absence of painful symptoms; teeth that have never been subjected to direct pulp capping; no history of hypersensitivity in the teeth to be restored; size of the isthmus with no more than 2/3 of the intercuspal distance; permanent dentition.	Presence of deleterious habits and bruxism;  bad oral health and presence of periodontal disease; patients who are suffering from severe systemic diseases or allergies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-2s5bhm	Clinical evaluation of two restorative approach for non-carious cervical lesions	Data analysis completed	Intervention	2018-06-20	<NULL>	<NULL>	1916	Clinical evaluation of Class V restorations using a semi direct technique - a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Instituto de Ciência e Tecnologia de São José dos Campos (ICT/SJC) - Universidade Estadual Paulista (UNESP)	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-2s5bhm	<NULL>	"• Be at least 18 years of age;
• Provide good general health;
• Do not introduce active decay or periodontal disease;
• Class V lesions, non-carious in canines premolars or with a minimum depth of 1 mm."	Medical condition that might interfere with the safety of the volunteer during the study period, or allergic reaction to substances and/or products used in the study; use of removable prosthesis with clamp resting on the study tooth; presence of caries or periodontal disease; patients under orthodontic treatment; tooth with endodontic treatment; smoking patients, patients with parafunctional habits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-8zmmgm	Effect of Baru Almond Intake by Adults with Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1924	Metabolic Syndrome: prevalence and effect of Physical Exercise and Nutritional Supplementation in adults and the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8zmmgm	<NULL>	Adult subjects; aged between 20 and 59 years; with self-reported diagnosis of type 2 diabetes mellitus	Individuals using insulin therapy; with a history of cardiovascular disease (infarct in the last six months, unstable angina, cardiac arrhythmia and stroke); cancer; diagnosed chronic lung disease; musculoskeletal problems ; neurological deficit; with frequent consumption of some type of nut (more than 2x / week); participants in a restriction and food education program; participants in a guided exercise program; individuals with nut  and / or seeds allergy, pregnant; nursing women; women in hormonal replacement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-3dmq83	Effects of probiotic administration in the elderly	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1926	Efficacy of administration of Probiotics in institutionalized elderly	<NULL>	1, single-arm-study, triple-blind	1	<NULL>	<NULL>	<NULL>	2017-07-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3dmq83	<NULL>	- To be 60 years or more; being institutionalized; obtain values between 10 and 24 in the Mini Mental State Examination (MMSE), to exclude individuals with very mild dementias and very severe dementias; be able to walk	-Be less than 60 years; not being institutionalized; obtain value less than 10 and greater than 24 in the Mini Mental State Examination (MMSE); not being able to walk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-5sgsxb	Effects of training the muscles of inspiration associated with the foundation workout of the wheelchair basketball tray on the strength of the breathing muscles and physical performance of high performance athletes	Data analysis completed	Intervention	2018-06-25	<NULL>	<NULL>	1928	Effects of inspiratory muscle training associated with the training of the wheelchair basketball tray foundation on the aerobic physical performance, cardiopulmonary and metabolic variables of high-performance athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5sgsxb	<NULL>	practice wheelchair basketball at a competitive level for more than five months; train at least three times a week; compete in official championships of the sport	smoking; presence of cardiovascular respiratory and motor alterations that made impossible the execution of evaluation or intervention protocols; inability to understand the techniques for implementing the evaluation and intervention protocols	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9p42nj	Proposal of a clinical guideline for attention to women with Urinary Incontinence in public health policy	Data analysis completed	Intervention	2018-06-27	<NULL>	<NULL>	1935	"A proposal of the superiority of clinical evaluation on urodynamics in
diagnosis of urinary incontinence in women"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-01	Universidade Federal de São Paulo	Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, EMESCAM,	https://ensaiosclinicos.gov.br/rg/RBR-9p42nj	<NULL>	Patients with complaints of urinary incontinence. Patients who submitted to the Urodynamic Study, Patients who signed the Free and Informed Consent Form	Patient with urinary infection at the moment of the Urodynamic Study. Patients with neurogenic bladder. Patients who refused to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-6cwmqc	Effect of Functional Bandaging on Women&apos;s Flexibility	Data analysis completed	Intervention	2018-06-27	<NULL>	<NULL>	1937	Acute effect of the application of Functional Elastic Bandage on the flexibility of active young women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-30	Faculdade Estácio de Sergipe	Faculdade Estácio de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6cwmqc	<NULL>	Physiotherapy students of the Faculdade Estácio de Sergipe; Women; age from 18 to 30 years; they did not practice regular physical exercises; they did not report low back pain at the time of the evaluation	Women who were in the menstrual period, puerperal, presence of scar in the application area and those who presented an allergy to functional elastic bandage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-7m7vc8	Telemonitoring to improve maternal confidence in breastfeeding	Data analysis completed	Intervention	2018-06-27	<NULL>	<NULL>	1938	Telemonitoring for improving maternal self-efficacy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-17	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7m7vc8	<NULL>	"Women in the immediate puerperal period, considered the period between the first and tenth day after childbirth;
Puerperas with at least six hours postpartum, since before that moment it would be inopportune to perform data collection, judging that the first hours after childbirth are characterized by emotional stress for the mother, making it even more difficult due to the physiological changes that occur;
Single term full term puerperal women (gestational age ? 37 weeks, &lt;41 weeks), since the clinical conditions and the environment in which the preterm newborn is hospitalized are factors that may hinder breastfeeding, in addition to that in some situations it is necessary to initiate the use of milk formulas in the child&apos;s diet;
Bereaved children 12 years of age or over, considering the Statute of the Child and Adolescent, Law No. 8,069 / 90;
Puerperas with newborns hospitalized in joint housing;
Puerperas that are practicing the AM;
Puerperas who have at least one telephone contact."	"Puerperas who declared their intention not to breastfeed;
Puerperas with age &lt;12 years or&gt; or equal to 60 years;
Puerperas that presented clinical intercurrences at the time of data collection (heart disease, nephropathy, diabetes, hypertension, among others);
Women with obstetric complications in the puerperal period (anemia, transvaginal bleeding, post-rachidial headache, among others);
Puerperas that presented some type of contraindication to breastfeeding (Acquired Immunodeficiency Syndrome, chemical dependency, among others);
Puerperas with mental restrictions that precluded the understanding of the instrument;
Puerperas who performed breast reduction or who had breast augmentation because, although these procedures do not contraindicate breastfeeding, in general, women who undergo breast reduction may decide not to breastfeed;
Puerperas with children hospitalized in the intensive care unit, judging that the sector is home to newborns with critical clinical conditions that may make breastfeeding impossible;
Puerperas whose children were born with disabilities that prevented or hindered breastfeeding (cleft palate, atresia of the esophagus, among others);
Puerperas with hearing impaired."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-9mys6q	Effect of the use of Toothpaste with Desensitizers in reducing Dental Sensitivity and Quality of Life after in-office Dental Bleaching	Data analysis completed	Intervention	2018-06-29	<NULL>	<NULL>	1945	Effect of the use of Dentifrices with Desensitizers in the ental Sensitivity reduction and Quality of Life after in-office Dental Bleaching: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9mys6q	<NULL>	with good oral health;  anterosuperior teeth with vitality, free of cavities and restorations on the vestibular surface; they should  be dissatisfied with the color of their teeth; they should have upper central incisors with coloration equal to or darker than A2, according to the Vita Classical color scale in order of luminosity.	stimulated or provoked dentin sensitivity; enamel cracks; dentinal exposures; severe intrinsic stains on the teeth (such as tetracycline or fluorosis); periodontal disease without treatment;  using any anti-inflammatory, analgesic and antioxidant action drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-6p9ncq	Physical exercise can reduce the accumulation of fat, improve the immunity and quality of blood in people living with HIV/aids.	Data analysis completed	Intervention	2018-07-04	<NULL>	<NULL>	1954	Effects of a program of physical exercise in body composition, immune system and blood changes of people living with HIV/AIDS: a clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-6p9ncq	<NULL>	Healthy volunteers; both genders; age between 18 and 50 years; carriers of the HIV virus; regular users of antiretroviral therapy; sedentary.	Volunteer smokers; alcohol abuse; physical limitation for exercise; chronic diseases; cardiorespiratory diseases; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic disorders; disuse of therapy; incorrect training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-7zcgdd	Effects of a water-based Exercise Program in elderly women with Knee Osteoarthritis	Data analysis completed	Intervention	2018-07-04	<NULL>	<NULL>	1956	Comparison of the effects of an Exercise Program performed in water or land in elderly with Hip or Knee Osteoarthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Departamento de Educação Física da Universidade Federal do Paraná	Centro Universitário Unibrasil	https://ensaiosclinicos.gov.br/rg/RBR-7zcgdd	<NULL>	Women; age from 60 years; diagnosed with knee osteoarthritis by a physician; able to walk with no help of assistive device; able to practice exercise.	Elderly women with diagnosed osteoarthritis or prosthesis in other lower limb joint; with medical restrictions to physical activity; participating on exercise program in last six months; with ortopaedic surgery in last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-92dbtx	Attention to the health of the elderly in primary health care	Data analysis completed	Intervention	2018-07-05	<NULL>	<NULL>	1961	Attention to the health of the elderly: a proposal for multidimensional evaluation and intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-92dbtx	<NULL>	Age greater than or equal to 60 years; male or female gender; be enrolled in the Primary Health Care of your municipality; and present preserved cognitive status.	Major physical disability; cognitive impairment; residence time in your municipality less than six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-3m9d74	Study of the usefulness of treatment of fungal infections in children with cancer and compromise of their immunity	Data analysis completed	Intervention	2018-07-05	<NULL>	<NULL>	1963	Efficacy of pre-emptive versus empirical antifungal therapy in children with cancer and high-risk febrile neutropenia: a randomized clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2013-07-01	Fondo Nacional de Desarrollo Cientifico y Tecnologico, Chile	Fondo Nacional de Desarrollo Cientifico y Tecnologico, Chile	https://ensaiosclinicos.gov.br/rg/RBR-3m9d74	<NULL>	"Children and adolescent with cancer; less or equal to 18 years of age; admitted because of a febrile neutropenia episode.
Informed consent of the parent or legal guardian
assent if older than 8 years of age."	"Children with hematopoietic stem cell transplant.
Children with cancer under voriconazole or posaconazole prophylaxis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-8m8v2x	Effects of Hammock Method in incubator on pain, sleep state and heart rate of premature newborns admitted to the Neonatal Intensive Care Unit	Data analysis completed	Intervention	2018-07-06	<NULL>	<NULL>	1972	Effects of Hammock Method on pain, sleep state and physiological variables of newborns admitted to the Neonatal Intensive Care Unit	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Católica de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8m8v2x	<NULL>	Patients hospitalized at the Neonatal Intensive Care Unit of a university hospital; considered  premature;  with gestational age less than 37 weeks; up to 60 days of age; clinically stable.	clinical instability; heart rate bigger then 180 beats per minute or less than 100 beats per minute; respiratory rate bigger than 60 breaths per minute or  less than 40 breaths per minute; SpO2 less than 89%; infants needing ventilatory support; presence of infectious process; use of phototherapy; neurological problems and congenital facial malformations that would not allow the application of the Pain Assessment Scale NIPS, as well as the Sleep State Assessment Scale and Adapted Vigilance of Brazelton.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-7zh8x7	Effects of Juice Fortification with Iron and Zinc in children	Data analysis completed	Intervention	2018-07-06	<NULL>	<NULL>	1973	Iron and Zinc Fortification effects on the Hemoglobin Level of preschool and school-age children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-25	Kilyos Assessoria Consultoria Cursos e Palestras LTDA	Kilyos Assessoria Consultoria Cursos e Palestras LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7zh8x7	<NULL>	Children from 0 to 17 years of age; both sexes; enrolled at the institution Reino da Garotada de Pos.	Individuals who are taking or have taken vitamin and/or mineral supplementation for the last two months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-9zftgs	Analysis of patient parameters related to oxygen therapy in patients undergoing anesthesia recovery	Data analysis completed	Intervention	2018-07-09	<NULL>	<NULL>	1979	Analysis of the Aldrete Kroulik scale related to oxygen therapy in patients undergoing anesthesia recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal de Minas Gerais - Escola de Enfermagem	Hospital das clínicas da UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9zftgs	<NULL>	Adult, age between 18 and 64 years; Classification of American Society of Anesthesiologists (ASA) 1 or 2; elective anesthetic-surgical procedure; general anesthesia; general conventional surgery; Peripheral oxygen saturation greater than or equal to 95% upon entering the Post Anesthesia Recovery Room.	Comorbidities of the respiratory system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-6q6ck3	The Upward and Downward Body Position of the Belly and the development of the premature child	Data analysis completed	Intervention	2018-07-09	<NULL>	<NULL>	1982	Influences of Body Position on the motor development of preterm infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-17	Universidade de Franca	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-6q6ck3	<NULL>	Preterm infants; born with under 37 weeks of pregnancy; in the city of Franca, and the beginning of high risk ambulatory monitoring in Franca`s  public health system.	The preterm infants (equal or &gt; 37 weeks); infant that have attended only the private health system; infants  that are already in process in high risk ambulatory in the public health system; and that ones that didn`t accepted the terms of participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-9p4f7d	needling technique and myofascial release in the treatment of neck and shoulder trigger point	Data analysis completed	Intervention	2018-07-12	<NULL>	<NULL>	2001	Acute eficcacy of dry needling versus myofascial pressure release in neck and shoulder trigger points: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-05-02	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9p4f7d	<NULL>	Adults aged 18 to 60 years old with chronic neck pain and symptoms lasting for at least twelve weeks; presenting with myofascial trigger point in only one upper trapezius muscle.	history of upper quadrant surgery; non-myofascial disorders, presence of myofascial trigger point bilaterally in the upper trapezius muscle; complaints of pain or injuries around the elbow or forearm; having received treatment for neck pain within the past twelve weeks; rariculopathies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-3chymm	Physiotherapeutic treatment in people who underwent hip replacement surgery	Data analysis completed	Intervention	2018-07-12	<NULL>	<NULL>	2002	Comparison between two physiotherapeutic rehabilitation methods in individuals submitted to total hip arthroplasty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-30	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3chymm	<NULL>	Age between 50 and 90 years; performed ATQ due to OA; four to five weeks postoperatively; who are not enrolled or participating in another physiotherapeutic treatment program; reside in Campo Grande or region.	History of stroke; Parkinson&apos;s disease; gait disturbances of neurological origin; clinical depression or disease that compromises the level of cognition; revisions of CKD, postoperative complications such as infection or dislocation; cardiopulmonary contraindications to perform physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-4nj799	Product development based on Ora-pro-nobis and its influence on feces, blood tests and anthropometric data in Adult Men	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2006	Product development based on Ora-pro-nobis (Pereskia aculeata Mill.) and its influence on the intestinal microbiota, antioxidant capacity, anti-inflammatory, biochemical and anthropometric parameters in Adult Men	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4nj799	<NULL>	Men between the ages of 20 and 50; Body mass index greater than or equal to 25 kg / m² and less than 40 kg / m²; Not having participated in a weight loss program in the last six months; Be healthy	History of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; restrictive diet practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-2nfy5q	The effect of selenium supplementation through Brazil nut consumption on inflammation, free radicals production and the expression of a protein that have this mineral and of microRNAs in obese women	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2009	Effect of selenium supplementation with Brazil nut (Bertholettia excelsa H.B.K.) on inflammation, oxidative stress and selenoprotein P and microRNAs expression in obese women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-19	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2nfy5q	<NULL>	BMI from 28.0 to 39.9 kg/m²; do not be pregnant or participating in another clinical trial; do not use vitamin-mineral supplements; do not smoke or drink alcohol chronically; do not practice intense physical activity; do not present food allergy to nuts or report a regular consumption of Brazil nuts.	Present recent infections, high-grade inflammation, chronic cardiovascular and gastrointestinal diseases (inflammatory bowel disease, celiac disease), and cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-42zsbt	Use of whey protein , vitamin D and  training in  older adults nursing home.	Data analysis completed	Intervention	2017-03-31	<NULL>	<NULL>	2012	Whey protein supplementation, vitamin D and resistance training in institutionalized older adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Universidade do Extremo Sul Catarinesnse	Universidade do Extremo Sul Catarinesnse	https://ensaiosclinicos.gov.br/rg/RBR-42zsbt	<NULL>	Permanent residence in the institution; be able to understand instructions in Portuguese and able to understand, accept and sign the Consent Form.	Older adults people with unstable disease and or terminal stage; impaired cognitive ability as assessed by (Mini-Mental State Examination, score &lt;24 points); hemiplegia impeding participants to use resistance training equipment; Parkinson&apos;s disease; permanently in wheelchairs or bed; or older adults who have performed resistance exercises; or regularly consumed a protein or vitamin D supplement in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-5kw3bz	Effect of tumeric extract supplementation on oxidative stress and inflammation after running	Data analysis completed	Intervention	2018-07-16	<NULL>	<NULL>	2014	Effect of Curcula longa L. supplementation on oxidative and inflammation markers after endurance exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-08	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5kw3bz	<NULL>	Men, eutrophic, aged between 25 and 50 years, amateur runners	Participants on weight loss diet/medication, diagnose with any acute or chronic diseases, taking medication that could affect the immune system, injured, smokers, and with a history of chronic alcoholism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-3y4bdk	Evaluation of brain and muscle activity in recovery of impaired upper limb after stroke	Data analysis completed	Intervention	2018-07-17	<NULL>	<NULL>	2016	Evaluation of central and peripheral excitability in individuals submitted to neurological rehabilitation for the paretic upper limb after Stroke	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3y4bdk	<NULL>	Clinical diagnosis of stroke; Chronic phase of the stroke; presence of left or right hemiparesis; both sexes; age greater than 18 years; present mental competence and present at least 10 degrees of wrist extension	Individuals with hemiplegia or severe spasticity, degree of severe neurological impairment; in the use of a myorelaxant drug and to have applied botulinum toxin in the muscles of the paretic upper limb for less than six months of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-8nbnc4	Evaluation of a program of physical activity in student health	Data analysis completed	Intervention	2018-07-17	<NULL>	<NULL>	2020	Evaluation of the effect of a physical activity program on aerobic fitness and cardiovascular risk markers in schoolchildren	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-8nbnc4	<NULL>	Healthy volunteers; both genders, aged between 9 and 15 years.	Volunteers who can not perform physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7mthsd	Influence of Smartphone use and Masticatory Behavior on food intake	Data analysis completed	Observational	2018-07-18	<NULL>	<NULL>	2024	Influence of Smartphone use, Masticatory Behavior on Stress status in students from a University at the souhtern region of Minas Gerais state	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Lavras - UFLA	Fundação de Amparo a Pesquisa do Estado de Minas Gerais - FAPEMIG	https://ensaiosclinicos.gov.br/rg/RBR-7mthsd	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 30 years; who thought they had a habit of using their cell phone while they were feeding	Individuals who reported food restriction of any kind (e.g. diet or specific feeding behavior for athletes)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-655c3z	Evaluation of composite resin restorations and glass ionomer cement by applying differently the adhesive system	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2035	"Study of the clinical performance of different accession strategies of noncarious
cervical lesions restorations"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Estadual Paulista - Faculdade de Odontologia de Araçatuba	Centro Universitário São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-655c3z	<NULL>	Age between 18 and 90 years old; regardless of genre; good health; no clinical history of allergies to dental products and remedies; presence of at least 4 non-carious cervical lesions; proper oral hygiene.	Chronic systemic disease; periodontal disease and without treatment; use of orthodontic appliances; severe bruxism, with more than 50% of wear.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-3bvjjm	Effectiveness of an educational booklet for the prevention of mother-to-child transmission of the Human Immunodeficiency Virus	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2036	Educational booklet for prevention of vertical Human HIV: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-16	Universidade Federal do Ceará	Departamento de Enfermagem - UFC	https://ensaiosclinicos.gov.br/rg/RBR-3bvjjm	<NULL>	Have proven HIV status, to be performing prenatal care in the chosen institutions during the study data collection period	Present a state of physical or mental health compromised in order to make data collection unfeasible, pregnant women living in the streets and incarcerated, so that the mother&apos;s accompaniment is unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-9f3wwp	Can turmeric powder treat asthma in children?	Data analysis completed	Intervention	2018-07-20	<NULL>	<NULL>	2037	Effects of Curcuma longa L. administration to children with persistent asthma	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2013-05-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Universidade de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9f3wwp	<NULL>	Children between 7 and 18 years; with a diagnostic of persistent asthma, mild, moderate or severe, controlled or not.	Allergy to C. longa; parental request; failure to adhere to the treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7tqc7k	Clinical pharmacology of tamoxifen in breast cancer patients	Data analysis completed	Observational	2018-07-23	<NULL>	<NULL>	2040	Tamoxifen population pharmacokinetics in breast cancer patients: metabolism study, genetic polymorphism, hormonal status and age	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-01-07	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7tqc7k	<NULL>	Breast cancer patients on adjuvant tamoxifen treatment for more than 80 days who have not been treated with other co-medications that may interfere with the study have been investigated. For the study, two groups of patients will be delimited according to age and hormonal status, being a premenopausal group (age less than 50 years) and another postmenopause (age higher than 60 years).	Patients with comorbidities that interfere with the metabolism of tamoxifen and the probe drugs were excluded; patients who have previously chemotherapy and / or target therapy; patients who have contraindications to the use of the probe drugs metoprolol, midazolam and fexofenadine; and psychiatric patients unable to understand ICF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-9792k8	Evaluation of ultrasonic whole-mouth instrumentation in the treatment of Chronic Periodontitis in diabetic patients	Data analysis completed	Intervention	2018-07-23	<NULL>	<NULL>	2042	Evaluation of periodontal debridement in the treatment of Chronic Periodontitis in diabetic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2010-07-19	Escola Bahiana de Medicina e Saúde Pública	Ambulatório Docente Assistencial da Bahiana	https://ensaiosclinicos.gov.br/rg/RBR-9792k8	<NULL>	Presented severe chronic periodontitis verified by the presence of periodontal pockets, loss of insertion and radiographic bone loss; presence of at least 8 teeth with probing depth greater than or equal to 5 mm and bleeding at probing, of these at least 2 teeth should have a depth of probing greater than or equal to 6 mm and 2 more with depth of probing greater than or equal to 7 mm; decompensated diabetics, glycated hemoglobin value greater than or equal to 7%; minimum of 15 teeth, excluding third molars	Periapical or pulp alterations on qualifying teeth, consumption of drugs known to affect periodontal status (antibiotic, anti-inflammatory, anticonvulsant, immunosuppressant, or calcium channel blocker) within the past 3 months, periodontal treatment, including subgingival scaling and root planning in the preceding 6 months,  systemic and immunological disorders other than diabetes that require prophylactic antibiotic coverage or that could influence response to treatment, smoking, pregnancy and cardiac pace-makers users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7354r6	Effects of Aerobic Training During Heart Rate Hemodialysis in Patients With Chronic Renal Disease	Data analysis completed	Intervention	2018-07-24	<NULL>	<NULL>	2045	Analysis of Heart Rate Variability in Exercise Supervised in Cicloergometry in Patients with Chronic Renal Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-12	Faculdade de Medicina do abc de Santo André.	Faculdade de Medicina do abc de Santo André.	https://ensaiosclinicos.gov.br/rg/RBR-7354r6	<NULL>	Outpatients of both sexes; literate; aged 18 years or over; who were undergoing renal treatment for at least six months	Volunteers who have unstable angina; uncontrolled systolic or diastolic arterial hypertension; use of antiarrhythmics; severe pneumopathies; acute systemic infection; severe renal osteodystrophy; disabling neurological and musculoskeletal disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-9b4v63	Evaluation of the characteristics of patients with lung disease who use oxygen for 12h / day in the period of one year	Data analysis completed	Observational	2018-07-25	<NULL>	<NULL>	2057	Evaluation of the evolutionary characteristics of patients with exercise-induced hypoxemia who use prolonged home oxygen therapy for 12 hours per day in a one-year period	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-11-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; Unesp - Faculdade de Medicina de Botucatu	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9b4v63	<NULL>	Effort Transient Hypoxemia; Do not present arterial hypoxemia at rest	Severe arterial hypoxemia; Cancer; Active smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-3cr9jh	Effect  of cinnamon supplementation on body weight, body composition, lipid profile, blood glucose, inflammatory markers and thyroid hormones in postmenopausal women.	Data analysis completed	Intervention	2018-07-25	<NULL>	<NULL>	2058	Effect  of cinnamon (Cinnamomum zeilannicum) supplementation on body weight, body composition, lipid profile, blood glucose, inflammatory markers and thyroid hormones in postmenopausal women.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-3cr9jh	<NULL>	Women with 12 months of amenorrhea; overweight or obese; age between 45 and 59 years.	use of anticoagulants, anti-lipidemic, antihypertensive and oral hypoglycemic agents and insulin; patients with hepatic dysfunction; hormone replacement; who has had chemotherapy; who has allergy or hypersensitivity to cinnamon.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-8bn3y2	Effect of Blocking a nerve in the neck and arm on inflammation in shoulder surgery. Comparative study	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2060	Effect of Interscalene Block on the inflammatory response in Shoulder surgery. Comparative study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Instituto Nacional de Rehabilitación	Instituto Nacional de Rehabilitación	https://ensaiosclinicos.gov.br/rg/RBR-8bn3y2	<NULL>	"Patients scheduled for arthroscopic surgery of the shoulder; Patients of both genders; Patients from 35 to 70 years age
Patients with American Society Anesthesiologists (ASA) physical status classification I or II; Patients who agree to participate in the study; Patients with leukocyte count within normal (count among 4 x 103/mm3 and 11 x 103/mm3)"	Patients with obesity (body mass index higher 30 Kg/m2); Patients with malnutrition; diabetes mellitus; metabolic syndrome; pre-existing coagulopathy; acute or chronic focus of infection; congenital or acquired immunological disease; collagen disease; local or systemic inflammatory disease; endocrine disease; oncological disease; psychiatric illness; organ failure; chronic pain in another bodily region; use of steroids or immunomodulators; chronic use of non-steroidal anti-inflammatory drugs; chronic use of alpha2-adrenergic agonists; previous surgery of the same shoulder and airway difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-62h256	"Evaluation of the spontaneous breathing test in 
predicting the withdrawal from mechanical ventilation after cardiac surgery 
in children"	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2061	"Evaluation of the efficacy of the spontaneous breathing test in 
predicting the success of extubation in the postoperative period of cardiac surgery 
in children: A randomized controlled trial."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-31	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-62h256	<NULL>	Children; aged 0-18 years; with congenital heart disease; admitted to the pediatric intensive care unit after cardiac surgery; receiving mechanical ventilation for more than 12 hours.	preoperative mechanical ventilation; uncontrolled pulmonary hypertension; refusal to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-9wqbx9	Comparative analysis of two solutions for miocardial protection in the correction of congenital cardiopathies.	Data analysis completed	Intervention	2018-07-26	<NULL>	<NULL>	2062	Comparative analysis of myocardial protection with HTK solution and hypothermic hyperkalemic blood solution in the correction of acyanogenic congenital cardiopathies – a randomized study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes	Hospital do Coração de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-9wqbx9	<NULL>	Children with acyanotic congenital cardiopathies submitted to corrective surgery with extracorporeal circulation and aortic clamping and volunteers to participate in the study.	Children operated for correction of atrial septal defect exclusively, reoperations, palliative surgeries, emergency surgeries, negative in participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-8p9v7v	Educational Intervention in Breastfeeding	Data analysis completed	Intervention	2018-07-30	<NULL>	<NULL>	2067	Technology in Breastfeeding: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-16	Universidade Estadual de Campinas - UNICAMP	Hospital Samaritano de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8p9v7v	<NULL>	Being in the mid-term in the joint housing; Accept participating in the study for up to 60 days after the birth of the baby; Have a landline or cell phone; Be practicing Exclusive Breastfeeding during the stay in the joint accommodation.	Mothers of high and medium risk babies or premature infants who were not able to breastfeed;Puerperas with communication difficulties, whether due to hearing impairment or not speaking our language (Brazilian Portuguese).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-9gchqr	Effects of a training in ensuring long term improvement of knowledge, attitudes and practices of community health workers in maternal and infant health	Data analysis completed	Intervention	2018-07-31	<NULL>	<NULL>	2073	Innovations in maternal and child care in Pernambuco - Quality evaluation cycle of maternal fetal care in maternity hospitals in Pernambuco	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq),	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-9gchqr	<NULL>	Community Health Workers who work in Family Health Units that are co-managed by the municipal health authority of Recife and the Institute of Integral Medicine Professor Fernando Figueira (IMIP).	Community Health Workers who were on vacation or on any type of leave during the data collection periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3qzhvg	Use of Subconjunctival Epinephrine in Retinal Surgeries in order to ease fundus visualization throughout surgery	Data analysis completed	Intervention	2018-08-01	<NULL>	<NULL>	2078	Efficacy of 0.1% Epinephrine Subconjunctival Injection versus Placebo in Intraoperative Mydriasis Maintenance during Vitrectomy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP	Hospital Universitário Onofre Lopes da Universidade Federal do Rio Grande do Norte - HUOL/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-3qzhvg	<NULL>	Patients submitted to isolated vitrectomy; Age of 18 or higher.	Pseudophakic patients with the cataract surgery performed in less than 6 months; History of uveitis; pseudoexfoliation; trauma; use of any systemic or topical anti-inflammatory medications within 2 weeks to surgery; Intraoperative complications; Patients submitted to scleral buckling or any anterior chamber procedure during vitrectomy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-9qdnws	Clinical evaluation of drugs in people with dry mouth	Data analysis completed	Intervention	2018-08-01	<NULL>	<NULL>	2080	clinical evaluation of Pilocarpine release systems in individuals with hyposalivation	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-04-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9qdnws	<NULL>	"Volunteers aged 18 or over.
With clinical diagnosis of hyposalivation salivary flow at rest less than or equal to 0.1 ml / min for at least two weeks before the research with no probability of resolution during the experimental period. There is no known allergy or sensitivity to pilocarpine.Ability to give informed consent in writing and meet all testing requirements."	No possibility of changing any drug with the potential to cause xerostomia within the research period. No intervention such as: radiotherapy, chemotherapy, surgery that could change the symptoms of xerostomia in the two weeks prior to the survey or during the study period. Eye problems contraindicate the use of parasympathetic agents (eg iridocyclitis, increased intraocular pressure). Other conditions, where there is a risk of worsening of medical problems during the evaluation period (eg severe or uncontrolled asthma or pulmonary disease, hypo or hypertension (uncontrolled), hyperthyroidism, uncontrolled seizures or cardiac arrhythmias, HIV and Hepatitis C). Established oral infections (eg, candidiasis, herpes infections, mucositis, canker sores).Pregnant women and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9ftypy	Pain after two different multimodal anesthesia techniques in obesity surgery	Data analysis completed	Intervention	2018-08-02	<NULL>	<NULL>	2085	Pain after two different multimodal anesthesia techniques in bariatric surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Santa Casa de Misericórida de Belo Horizonte	Hospital São José do Avaí	https://ensaiosclinicos.gov.br/rg/RBR-9ftypy	<NULL>	Patients sequentially scheduled for Roux-en-Y Reduction Gastroplasty; age between 18 and 70 years; agreement and signature of the free and informed consent term.	Chronic use of opioids; patients with chronic pain; history of chemical dependence; allergic to any of the medications used in the study; patients with any cardiac, respiratory, renal or hepatic pathology that is considered severe.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7nw8wz	Impact of using an automatic bolus calculator for glycemic control in patients with type 1 diabetes mellitus	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2094	Impact of using an Automatic Bolus Calculator for glycemic control in patients with type 1 Diabetes Mellitus receiving multiple daily Insulin injections	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Irmandade Santa Casa de Misericordia de Sao Paulo	Irmandade Santa Casa de Misericordia de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7nw8wz	<NULL>	Patients &gt;16 years old; HbA1c over ou equal to 6.5%; T1DM diagnosis for more than 1 year; being treated with multiple daily insulin injections (MDI); pre-prandial insulin doses adjusted according to carbohydrate count	T2DM or T1DM diagnosis for less than 1 year from the screening date; use of oral hypoglycemic agents, apart from metformin; fixed insulin injections; or using insulin dosage tables according to their blood glucose tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-3cz6jg	Clinical characteristics of a group of smokers in a smoking cessation program	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2096	Clinical and epidemiological profile of a group of smokers in a smoking cessation program	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-10	Escola Baiana de Medicina e Saúde Pública	Escola Baiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-3cz6jg	<NULL>	Smoker. Over 18 years old. Sign the term of Free consent	Carrier of serious heart disease. Carrier of mental disorders. Do not sign the Term of Free Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9b4gwz	Analysis of the type of patient submitted to heart surgery and the period during and after surgery at Hospital and Maternity Marieta Konder Bornhausen	Data analysis completed	Intervention	2018-08-06	<NULL>	<NULL>	2097	Analysis of the surgical profile and the immediate postoperative and postoperative period of patients submitted to cardiac surgery at the Hospital and Maternity Hospital Marieta Konder Bornhausen	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade do Vale do Itajaí	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-9b4gwz	<NULL>	Patients (or caregivers) who signed the ICF, who were hospitalized in an intensive care setting after cardiac surgery.	Patients who underwent mechanical ventilation for more than 24 hours; patients who did not tolerate the use of the NIV mask; protocol follow-up error	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-4qvfwf	Prolonged slow expiration technique in Preterm infants with Bronchopulmonary Dysplasia: is there some benefits comparing with conventional technique?	Data analysis completed	Intervention	2018-08-10	<NULL>	<NULL>	2110	Techiniques of Physical therapy respiratory and food performance of Newborn with preterm Dysplasia Bronchopulmonary	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal de Santa Maria	Hospital de Caridade Dr Astrogildo de Azevedo	https://ensaiosclinicos.gov.br/rg/RBR-4qvfwf	<NULL>	prematurity; bronchopulmonary dysplasia	malformations head, neck and / or heart; genetic syndromes; intracranial hemorrhage (ICH) grade III and IV; perinatal asphyxia (Apgar score &lt;5 at 5 minutes of life); bilirubin encephalopathy, shortened frenulum of the tongue and not parental consent and / or legal guardians for the child&apos;s participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-43vpmr	Assessment of skin and scar quality after Fat Infiltration	Data analysis completed	Intervention	2018-08-10	<NULL>	<NULL>	2113	Assessment of skin and scar quality after Fat Grafting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de Pernambuco - UFPE	Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-43vpmr	<NULL>	Women; abdominoplasty indication; between 20 and 50 years; BMI below 30; previous cesarean scar.	Smokers; patients with systemic disease; use of any medication for chronic use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-528pyq	Comparison of active videogames And running practices on Endothelial, Inflammatory, Cardiovascular And Metabolic Parameters in Type 1 Diabetes people	Data analysis completed	Intervention	2018-08-13	<NULL>	<NULL>	2117	Active video vames: A coadjuvant in the treatment of Diabetes Mellitus types 1 and 2?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-528pyq	<NULL>	Were included male and female subjects Patients who regularly use insulin and do not use anceolytics; anti-inflammatories; antibiotics and or beta-blockers; do not have an osteo-articular; muscular restriction; peripheral neuropathy or any involvement or complication caused by diabetes that prevents the sessions.	All DM1 were excluded who initiate the practice of other physical exercises during the period of study will be excluded, obtain any type of complication that may be aggravated by VGA practice or by medical report, requesting the absence exit of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-67hvhy	Evaluation of treatment for the heart on the sensation of pain in people who are hypertensive	Data analysis completed	Intervention	2018-08-15	<NULL>	<NULL>	2120	Evaluation of a cardiac rehabilitation program on the nociceptive threshold in hypertensive individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-02	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-67hvhy	<NULL>	Individuals with a diagnosis of hypertension; Normotensive individuals; Both sexes; Adults over 40 years.	History of unstable angina, thrombophlebitis, recent embolism, infection, atrioventricular block (without pacemakers), acute myocarditis or pericarditis, arrhythmias, untreated mitral stenosis, decompensated heart failure, uncontrolled hypertension, ST segment depression, diabetes mellitus uncontrolled, fever, smokers, use of continuous analgesic, antidepressants, tranquillizers or any medication that could interfere with the nociceptive threshold, drugs and alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-7cyp6t	Epidural anesthesia with ropivacaine and its effects in the duration of the muscular relaxation produced by rocuronium.	Data analysis completed	Intervention	2018-08-17	<NULL>	<NULL>	2123	Epidural Adminstration of ropivacaine and its effects on the pharmacodynamics of rocuronium: randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-03	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7cyp6t	<NULL>	Elective Abdominal Surgeries performed under general anesthesia with or without association of epidural analgesia; female sex; age between 18 and 65 years old. Use of neuromuscular blocking agents; physical state ASA 1 and 2.	neuromuscular, renal and hepatic diseases; BMI greater than 32.5 or less than 20.0 kg.m-2; hydroelectrolytic and acid-base disorders; use of drugs that interact with neuromuscular blockers; contraindication to spinal blocks; history of hypersensitivity to drugs used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-2phxzm	Mouthwashes for treatment of nas breath	Data analysis completed	Intervention	2018-08-17	<NULL>	<NULL>	2124	Chemical control of oral halitoses by mouthwashes: evaluation by gas chromatography and organoleptic test	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-04	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2phxzm	<NULL>	"Presence of at least 20 natural teeth;
Good oral hygiene;
Absence of periodontal disease, xerostomia, or any chronic inflammatory process;
Patients with halitosis of intra-oral cause."	"Smokers;
Alchoolics;
Pregnant or lactating;
Carriers of systemic diseases (hepatic, renal, diabetes);
Presence of pharyngeal or tonsillar infection;
Upper or lower respiratory tract inflammation;
Carriers of removable prostheses, clinically unsatisfactory fixed prostheses, dental caries, lesions on the buccal mucosa;
Individuals who have used antibiotics in the last 3 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-62b4z2	Relationship of changes in heart rate with stress test results in patients with Chronic Obstructive Pulmonary Disease	Data analysis completed	Observational	2018-08-20	<NULL>	<NULL>	2127	Correlation of cardiac frequency variability and ergoespirometry in patient with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-18	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-62b4z2	<NULL>	We selected patients with moderate to severe chronic obstructive pulmonary disease, former smokers of both genders, who completed a pulmonary rehabilitation program with a minimum of eight weeks	Patients who did not complete the eight-week rehabilitation program, patients who require oxygen during ergospirometry, or who are unable to participate in the study, were excluded from the study. Patients with mild impairment of Chronic Obstructive Pulmonary Disease, or with associated heart disease, understand or perform the research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-5hzq77	Good bacterias in gingival disease	Data analysis completed	Intervention	2018-08-20	<NULL>	<NULL>	2130	Introduction of probiotics in periodontal therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Estadual do Rio de Janeiro	Rit Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-5hzq77	<NULL>	The  participants  according  to  the  inclusion  criteria  were  patients  with  chronic periodontitis with at least 20 teeth and Probing Pocket Depth (PPD) 5 mm in at least 6 sites	Without systemic diasease; no periodontal treatment in the last 24 months; without the use of  antibiotics  in  the  last  6  months;  without  pregnancy;  without  orthodontic  therapy;  non-smokers; no cardiac pacemaker users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-73xp36	Immediate effect of the virtual reality game for the upper limb on the brain and muscular activity in the patient after stroke.	Data analysis completed	Intervention	2018-08-21	<NULL>	<NULL>	2134	Evaluation of central and peripheral excitability in individuals submitted to neurological rehabilitation for the paretic upper limb after stroke.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-25	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-73xp36	<NULL>	Inclusion criteria were to present clinical diagnosis of ischemic or hemorrhagic stroke; being in the chronic phase of the disease with an occurrence of more than 3 months; presence of left or right hemiparesis; being of both sexes; regardless of ethnicity, race, and socioeconomic-cultural level, and to present mental competence assessed by the Mental State Mini-Exam.	Low level of mental competence; present hemiplegia or severe spasticity (assessed by Modified Ashworth scale - grade 4), and make use of a myorelaxant medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-9337nv	Nursing intervention to reduce symptoms in cancer patients	Data analysis completed	Intervention	2018-08-22	<NULL>	<NULL>	2138	Multimodal nursing intervention to reduce  cancer treatment related symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-23	Escola de Enfermagem da Universidade de São Paulo	Instituto do Câncer do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9337nv	<NULL>	Breast cancer; colorectal cancer or prostate cancer; be treated with chemotherapy or radiation; older than 18 years; minimum education of four years; not present language dysfunction and oriented in time and space.	Patients illiterate or with cognitive disabilities (dementia / psychosis); patients with high demand for care (Karnofsky score of &lt;40).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-52shjp	Prevention of body temperature drop during surgery, using different models of heaters.	Data analysis completed	Intervention	2018-08-22	<NULL>	<NULL>	2139	Prevent  perioperative hypothermia using diferent heathing method	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-10-20	Faculdade de Ciencias Médicas da Unicamp	Faculdade de Ciencias Médicas da Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-52shjp	<NULL>	Patients subjected to gastroenterológicas elective surgeries; of both sexes; Aged between 18 years and 60 years; With physical state Ps1-PS4, according to ASA-PS American Society of Anesthesiologists physical state	Patients with IMC less than 20 greater than 30; extremes of age; Initial body temperature tympanic below 36 °c or equal to or greater than 38 °c; Transfusion of more than two bags of only; Replacement volume more than 30% of the recommended by the local anesthesia service,15 ml/kg 1st-hour weight, 10 ml/kg subsequent weight and patients in which the surgical dryness proposed in the study objective was not performed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-2hz3tg	Effect of administration  beneficial bacteria on the health in overweight women	Data analysis completed	Intervention	2015-06-10	<NULL>	<NULL>	2141	Effect of administration of probiotics on inflammatory markers in overweight women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-2hz3tg	<NULL>	body mass index between 25 and 39.9 kg/m2; aged between 20 and 64 years; who receive outpatient care in general nutrition and nutrition in endocrinology hospital of the University Federal of Goiás	Do not perform all evaluations; Participate in a program of food restriction; Body mass index less than 25 kg/m2 or 40 kg/m2; Patients with immune diseases or immunosuppressive drugs; Patients with liver or kidney disease; chronic alcoholics; In using nutritional supplements;  Pregnant women; In insulin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-77h2pr	Effect of video games on rehabilitation in patients in the burn therapy unit in sergipe	Data analysis completed	Intervention	2018-08-23	<NULL>	<NULL>	2143	Effects of virtual reality in patients of the therapy of the therapy unit of Sergipe burns.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-77h2pr	<NULL>	Patients with burns 2nd and 3rd grades in the thorax and upper limbs, which are hemodynamically stable, suitable for rehabilitation in terms of cognitive ability to follow simple commands, have normal or corrected vision and hearing with the use of orthoses.	Patients with sequelae of central and peripheral burns, encephalopathies, fractures, muscular distension, psychiatric disorder, use of artificial airway and mechanical ventilatory support.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-4739sb	The Effect of Horse-Assisted Therapy on Performance in Children with Cerebral Palsy: Case Study	Data analysis completed	Intervention	2018-08-23	<NULL>	<NULL>	2144	The effect of equine therapy on functional performance in children with Cerebral Palsy: a case study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Faculdade Dinâmica do Vale do Piranga	Centro de Equoterapia Animal Amigo	https://ensaiosclinicos.gov.br/rg/RBR-4739sb	<NULL>	Child of 12 years; diagnosis of Cerebral Palsy	Equinofobia; hip dislocation; deformity of the vertebral column	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-7prdf2	Study on the body image of Brazilian adolescents	Data analysis completed	Intervention	2018-08-23	<NULL>	<NULL>	2147	Body Image among Brazilian adolescents: diagnosis and intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal de Juiz de Fora	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais - Campus Barbacena	https://ensaiosclinicos.gov.br/rg/RBR-7prdf2	<NULL>	To be included in this study, the adolescent/youth should be enrolled in one of the integrated technical courses or undergraduate degree of the campuses of Barbacena, Rio Pomba and Juiz de Fora from IF Sudeste MG, have no mental or eating disorder diagnosed and wish to participate voluntarily in the research.	Students whose parents do not sign the Consent Term will be excluded, those who have a mental or eating disorder diagnosed or do not wish to participate in this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2r4d3h	Evaluation of a Diabetes Education Program in the clinical evolution of patients with type 1 diabetes mellitus treated at two public services in Brazil	Data analysis completed	Intervention	2018-08-27	<NULL>	<NULL>	2152	Evaluation of the efficacy of a Structured Diabetes Education Program in the clinical evolution of patients with type 1 diabetes mellitus treated at two regional reference services in Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Instituto da Criança com Diabetes do Rio Grande do Sul - ICDRS	Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição	https://ensaiosclinicos.gov.br/rg/RBR-2r4d3h	<NULL>	Have diagnosis Type 1 Diabetes Mellitus; be from eight and 21 years old (incomplete); have less than five years of disease; be willing to participate in the educational sessions; sign the consent form (TCLE)	Non adhere to the consent form (TCLE); have visual, auditory deficiency,  active psychiatric illness or mental disability  that compromises understanding of the educational content; participating or having participated in another diabetes education program at the time of inclusion in the study; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-2w97k4	Evaluations of the effect of smoke in the periodontal surgery technique using a microscope  for treatment of root exposure caused by gingival recession	Data analysis completed	Intervention	2018-08-28	<NULL>	<NULL>	2154	Evaluations the periodontal microsurgery technique for treatment of gingival recession on smokers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-08-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Fundação de Amparo à Pesquisa do estado da Bahia (FAPESB)	https://ensaiosclinicos.gov.br/rg/RBR-2w97k4	<NULL>	"Patients smokers and nonsmokers with Miller Class I and II buccal gingival recessions equal ou greater  then 2.0 mm located in maxillary canines or premolars; probing depth (PD) smaller then 3 mm without probing bleeding; absence of cavities, restorations , pulp alterations and orthodontic appliances in the areas to be treated; good general health; absence of contraindications to the surgical procedure; did not use medications that could interfere with the health of periodontal tissue or healing.
Smokers should report a minimum consumption of 10 cigarettes per day for at least 5 years."	Smokers with daily consumption of tobacco less than 10 cigarettes per day for at least 5 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-846kgn	Evaluation of the durability of the effects of a knee joint mobilization in individuals with osteoarthritis	Data analysis completed	Intervention	2017-07-17	<NULL>	<NULL>	2155	Evaluation of the durability of the effects of Mulligan&apos;s mobilization with moviment (MWM) in secondary hypalgesia,functional and emotional aspects, in individuals with diagnosis of knee Osteoarthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-846kgn	<NULL>	Diagnosis of symptomatic knee osteoarthritis, mild or moderate, with radiological evidence for at least six months; Between the ages of 50 and 70; Falls within a pain range of three to seven on the Visual Analogue Scale (VAS).	Have other musculoskeletal changes; Chronic inflammatory diseases such as autoimmune diseases (rheumatoid arthritis, lupus and gout); diffuse pain in the body (fibromyalgia); neuromuscular changes such as Parkinson&apos;s disease; other mental illnesses that may make it difficult to understand and perform the procedures requested in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-75t8zp	Effects of Pilates Training on Muscle Activity during disturbance in females with chronic low back pain	Data analysis completed	Intervention	2018-08-30	<NULL>	<NULL>	2158	Effect of a pilates training program on postural control of women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-13	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-75t8zp	<NULL>	Participants who did not present: Vestibular problems ie Labirintite; Somatosensory deficiencies such as Diabetic Neuropathy; Neurological problems such as stroke, Parkinson&apos;s, Multiple Sclerosis; Any other type of impairment that could influence permanence in the orthostatic position; Had the consent of a physician to practice the Pilates classes alone; Sign the TCLE; Be between 25 and 55 years of age; Classify as physically inactive or insufficiently active.	People who participated in other physical activities; Women who did not attend Pilates classes regularly; Who became pregnant during the survey period; Have left the license for more than three months for any eventuality; Did not complete all the tests / evaluations of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-9p9drm	The efficacy of chewing gum for pain control during orthodontic treatment	Data analysis completed	Intervention	2018-09-10	<NULL>	<NULL>	2182	The efficacy of chewing gum for pain control during orthodontic treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-9p9drm	<NULL>	Patientes with aged 13 until 40 years; complete permanent dentition; moderate crowding.	Patients with elastic separators, phenylalanine allergy, TMJ symptoms, chronic use of analgesics and those that would need to use medicine for any other reason were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-33tdwy	Sexual counseling for women who withdraw the breast	Data analysis completed	Intervention	2017-06-19	<NULL>	<NULL>	2186	Intervention of Sexual Counselling for mastectomized: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-11	Maternidade Escola Assis Chateaubriand	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-33tdwy	<NULL>	"Mastectomized women; To have at least six months of surgery; To be over 18 years of age;
To have started sexual activity"	Mastectomized women taking antidepressants; Mastectomized women with disabling diseases that prevent the sexual act.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2brcxq	Association of Infection with Parenteral Nutrition	Data analysis completed	Observational	2018-09-12	<NULL>	<NULL>	2191	Infection associated with Parenteral Nutrition: Retrospective cohort study in tertiary hospital and systematic review with meta-analysis on the association of Parenteral Nutrition with infections and mortality	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Programa Pós-Graduação em Endocrinologia da Universidade Federal do Rio Grande do Sul	Programa Pós-Graduação em Endocrinologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2brcxq	<NULL>	Adult patients submitted to NP admitted to the Hospital de Clínicas de Porto Alegre (HCPA).	"Central peripheral insertion catheter.
Central catheter for long stay.
Sustained parenteral nutrition less than 72 h after onset."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-7v7tj5	Clinical Study on the effect of Bleaching Toothpastes	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	2202	Clinical Trial on the effectiveness of Bleaching Toothpastes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7v7tj5	<NULL>	Both genders; older than 18 years; presence of all natural anterior superior teeth; vitalized; naturally or physiologically darkened; without restorations involving the vestibular faces; with color darker or equal to A3 in the VITA scale of the tint guide; good oral health.	Patients with dental sensitivity; cervical lesions or fractures; smokers; pregnant women and infants; children and adolescents (under 18 years of age); previous history of cancerous lesions; caries and periodontal disease; prosthetics and / or previous restorations were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-6by9h2	Influence of Aquatic Physiotherapy in the weight-bearing symmetry in the sit-to-stand transfer in hemiparetics after Stroke	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	2207	Influence of Functional Aquatic Physiotherapy in the weight-bearing symmetry in the sit-to-stand transfer in hemiparetics after Stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-10	Associação de Assistência à Criança Deficiente	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-6by9h2	<NULL>	Clinical diagnosis of stroke (6 months – 5 years); aged between 18 and 65 years; ability to follow the instructions; sit-to-stand transfer independence – hold standing position for at least 3 seconds; without Physical Therapy at the moment.	Non-collaborative patients, those who had a new episode of stroke during the study and those who underwent orthopedic surgery less than 12 months and peripheral blocks less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-9d6368	Laser treatment for thyroid benign tumors or follow-up	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2209	Percutaneous Laser ablation of benign thyroid nodules versus follow-up	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-05	Instituto de Radiologia do Hospital das Clínicas / Faculdade de Medicina da Universidade de São Paulo	Comissão de Ética para Análise de Projetos de Pesquisa - CAPPesq	https://ensaiosclinicos.gov.br/rg/RBR-9d6368	<NULL>	solid or solid-cystic with less than 20% of liquid benign thyroid nodule at ultrasound; nodule volume between 5-18 mL; serum levels of thyroid hormone and TSH in the normal range values; two negative cytological evaluations for malignancy in the last 6 months; no thyroid autoimmunity expressed by ultrasound or auto-antibody elevation over 100% of the standard level; calcitonin level under normal range values; anticoagulant treatment interrupted;	age under 18 years; extensive goiter; cystic nodule; hyper functioning nodule; elevated TSH levels; autoimmune therapy; active anticoagulant therapy; cytological specimens with suspected malignancy; pregnancy and breast-feeding; thyroiditis; asymptomatic nodule;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-4mz6w9	Effect of Inspiratory and Expiratory Training on autonomic modulation, exercise capacity and pulmonary capacity of Chronic Obstructive Pulmonary Disease patients	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2210	"Influence of Respiratory Muscle Training on hemodynamic changes,
pulmonary and autonomic diseases in patients with COPD"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-4mz6w9	<NULL>	Volunteers with the diagnosis of Chronic Obstructive Pulmonary Disease; who had inspiratory muscle weakness (70% of predicted maximal inspiratory pressure); with absence of heart failure; with stable pharmacological treatment; and with no comorbidity such as type 2 diabetes mellitus and hypertension.	Volunteers who had acute myocardial infarction three months before inclusion in the study; unstable ventricular arrhythmia or in the last three months before onset; acute respiratory disease; rheumatic diseases; degenerative diseases; neurological sequelae and cognitive deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-77tjsw	The efect of Glutamine in the defense system of patients with HIV/AIDS	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2211	The influence of Glutamine in the Immunological system of patients with HIV/AIDS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-04	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-77tjsw	<NULL>	The study included patients considered to be adherent to the treatment, both men and women, between 18 and 50 years of age with positive serology for HIV/AIDS, enrolled in this unit, in regular treatment / follow-up and in the use of antiretroviral drugs (zidovudine / lamivudine and lopinavir / ritonavir) for at least two years, with Global Subjective Assessment = A (well nourished), who accepted to participate in the research with prior signature of the Informed Consent Term (TCLE)	Exclusion criterion were: patients who started treatment less than 2 years ago; with comorbidities; with a history of gastrointestinal tract operations; who used drugs that induced metabolic changes, as well as drug addicts and alcoholics. Also excluded were clinically severe or unstable patients, in addition to pregnant or infants; people with some mental disorder; who used glutamine or other supplement; patients with Global Subjective Evaluation B or C (moderately undernourished or severely undernourished) and patients who did not agree to participate in the study or did not sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-7j96vz	Physiological curve of body temperature and implications for occurrence of undesirable events among university students	Data analysis completed	Intervention	2018-09-18	<NULL>	<NULL>	2212	Physiological curve of body temperature and implications for occurrence of adverse effects between university	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-23	Universidade Federal Fluminense	Jennifer Costa Sales Honorato	https://ensaiosclinicos.gov.br/rg/RBR-7j96vz	<NULL>	Healthy volunteers, age from 18 to 44 years; of both genders; Undergraduate students of the Nursing course at the Federal Fluminense University, individuals who have e-mail and cell phone numbers to receive research notifications and who entered the college entrance examination.	Individuals with some recurrent acute infectious process; with conditions that cause sensitivity in the region of the wrists; Individuals with known endocrine disfunctions that have an impact on thermoregulation (hyperthyroidism / hypothyroidism, hypopituitarism, myxedema, pheochromocytoma; pregnant women and patients with pacemakers)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-53ds9z	Effects of short-term memory therapy using spoken stimuli and reading stories in children who do not understand what they read	Data analysis completed	Intervention	2018-09-19	<NULL>	<NULL>	2214	Effects of the intervention in phonological memory and shared reading of history in school children with difficulties in reading comprehension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulos	FAculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-53ds9z	<NULL>	age between 8 and 10 years and 11 months; attending the fourth or fifth year of elementary school; not having speech therapy because of difficulties in reading, writing and speaking; have no syndromes or hearing or visual loss.	percentage greater than 25% of absences during the 15 days of therapy (intervention meetings); not carry out the activities during the meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-9s6jpc	Evaluation of educational Actions to reduce sodium consumption in adults	Data analysis completed	Intervention	2018-09-20	<NULL>	<NULL>	2217	Evaluation of the impact of Actions to reduce sodium consumption in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-02	Universidade Federal do Espírito Santo	Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9s6jpc	<NULL>	To belong to the studied institution and to accept to participate in the research	Cognitive limitations that impede the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-6bxq36	Effect of educational programs to promove adverse events reporting	Data analysis completed	Intervention	2018-09-21	<NULL>	<NULL>	2222	Impact of educational intervension for promotion adverse events culture	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-04	Faculdade de Ciências Farmacêuticas Campus Araraquara UNESP	Conselho Nacional Para desenvolvimento Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6bxq36	<NULL>	Health professionals who worked in the care area of the hospital dependencies during the intervention period; in full; morning, afternoon and evening shifts; with no distinction of professional category	professionals of both genders, on health leave, maternity leave or other reasons for more than 3 months, residents and trainees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-5byrsc	Effect of supplementation with a synbiotic on the inflammatory response in children and adolescents with cystic fibrosis	Data analysis completed	Intervention	2016-03-11	<NULL>	<NULL>	2227	Effect of supplementation with a synbiotic on markers of the inflammatory response in children and adolescents with cystic fibrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-03	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5byrsc	<NULL>	Cystic fibrosis group: Children and adolescents up to and including age zero and less than or equal to 15 years; to present a diagnosis of HR based on the sweat test (sweat chloride 60 mmol / L); clinically at least 30 days prior to data collection. For controls without cystic fibrosis: children and adolescents aged 0 years and 15 years without cystic fibrosis; clinically stable at least 30 days prior to data collection	Subjects with fever, trauma, inflammatory diseases (asthma, inflammatory bowel disease, rheumatic disease), psychiatric, degenerative, cardiovascular, diabetes, glucose intolerance, renal failure, primary or secondary immunodeficiency Subjects undergoing antibiotic use at baseline, hormones, non-hormonal anti-inflammatory drugs, immunosuppressants and antihistamines, up to 30 days prior to data collection and subjects in pulmonary exacerbation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-3b5frf	The effect of a mouthwash on the reduction of bad breath	Data analysis completed	Intervention	2018-09-25	<NULL>	<NULL>	2235	The effect of strontium in the reduction of volatile sulfur gases in the oral cavity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-03	Universidade Estadual do Rio de Janeiro	Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3b5frf	<NULL>	They were non-smokers; with no self-reported history of systemic diseases or periodontal disease; no complaints of halitosis or xerostomia; and no self-reported regular use of medicines.	Without systemic diasease; no periodontal treatment in the last 24 months; without the use of antibiotics in the last 6 months; without pregnancy; without orthodontic therapy; non-smokers; no cardiac pacemaker users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-5nf6wd	Community Intervention for elderly with Depression	Data analysis completed	Intervention	2018-09-26	<NULL>	<NULL>	2241	Evaluation of the feasibility of a cluter randomized controlled  trial for the Management of Depression in elderly people living in socioeconomically disadvantaged areas of São Paulo, Brazil: a pilot study	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Faculdade de Medicina da Universidade de São Paulo	King's College	https://ensaiosclinicos.gov.br/rg/RBR-5nf6wd	<NULL>	Individuals aged 60 years and over, enrolled in two Basic Health Units with Family Health Strategy in the municipality of São Paulo; depression assessed with the Patient Health Questionnaire-9 (score 10 or more no PHQ-9).	Complete deafness; terminal illness; risk of suicide; or an inability to communicate (e.g., due to cognitive impairment either reported by a family member or detected by the researcher).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-6p2vsf	Cognitive therapy may improve quality of life in people with acromegaly	Data analysis completed	Intervention	2018-10-01	<NULL>	<NULL>	2251	Think healthy: contributions of cognitive therapy to increase the quality of life in patients with acromegaly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6p2vsf	<NULL>	The criteria for inclusion in the group are patients with acromegaly in ambulatory follow-up, of both gender, aged between 18 and 70 years, with intellectual capacity to follow the intervention and who agree to participate in the study.	There are criteria for excluding the sample: suicide risk; absence of commitment to the fulfillment of written tasks and being accompanied in therapy. Sample participants shall be considered as sample loss if they are absent, not justified, for two consecutive sessions or for three alternating sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-4tk434	Evaluation of resin with antimicrobial	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2254	In situ evaluation of the microbiological behavior of acrylic resins with an incorporation of chlorhexidine	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-15	Universidade do Estado do Rio de Janeiro	Departamento de Prótese da Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4tk434	<NULL>	Male or female, aged between 18 to 32, healthy with no history or presence of a systemic disease, and absence of active caries or periodontal disease.	Individuals with removable prosthesis, orthodontic appliances or any dental implants; pregnant or breastfeeding; smokers; presence of cleft palate that precludes the wearing of a retainer; use of an antimicrobial mouthwash prior to enrolment in the study; and use of antibiotics against infectious diseases during the 3 months prior to the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-5q3h2t	The analysis of the stimuli was initiated by the use of the X-Box video game associated with Kinect, on the balance, functional mobility and motor network of individuals with Down syndrome	Data analysis completed	Intervention	2018-10-02	<NULL>	<NULL>	2259	Effect of stimuli produced by X-Box Kinect on the balance, functional mobility and motor coordination of individuals with Down syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-27	Universidade Metodista de Piracicaba - UNIMEP	Associação Síndrome de Down de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5q3h2t	<NULL>	Volunteers with Down Syndrome between the ages of 4 and 14 who are able to understand the guidelines for conducting clinical trials and do not rely on help in performing the Daily Life Activities.	Volunteers with coexisting autism, cerebral palsy, blindness and deafness, previous neurological diseases, such as traumatic brain injury, muscular dystrophies and epilepsy, with institutionalized Down syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-49ngpt	Effects of Prone and Kangaroo Positioning in preterm infants	Data analysis completed	Intervention	2018-10-04	<NULL>	<NULL>	2263	Comparison of the effects of Prone Position and Skin-to-skin contact on cardiopulmonary parameters in premature infants with Bronchopulmonary Dysplasia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-02	Hospital Agamenon Magalhães	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-49ngpt	<NULL>	Premature infants; gestational age range of 25-32 weeks; both genders; with bronchopulmonary dysplasia; cronological age between 28 and 60 days; clinically stable; using nasal cannula or oxyhood up to 40% or room air	Infants with bronchopulmonary dysplasia at invasive or noninvasive support; risk factors for respiratory instability; risk factors for cardiovascular instability; unstable to handling; contact isolation due to infection; mother´s refuse in staying in skin-to-skin contact position.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6z4t5y	The impact of a strategy to motivate people with Type II Diabetes Mellitus to walk	Data analysis completed	Intervention	2018-10-16	<NULL>	<NULL>	2282	Impact of motivational strategy and intention activation in the physical activity practice, walking modality, in people with Type II Diabetes Mellitus - Controlled Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-02	Universidade Estadual de Campinas	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6z4t5y	<NULL>	Patients diagnosed with T2DM. Older than 18 years. With medical release for the practice of PA. In regular clinical follow-up at the five above-mentioned units.	Users with mental disorders (recorded in medical records). Users in clinical conditions that made it impossible for them to perform regular PA. Users already practicing  PA prior to the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-7hf8jw	Effects of Physical Exercise on muscle mass, strength, and blood markers in HIV Patients	Data analysis completed	Intervention	2018-02-27	<NULL>	<NULL>	2284	"Effects of 16 weeks of Strength Training on muscle mass, strength and
markers of oxidative stress in HIV patients"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	CEFE - Programa de Pós-Graduação em Educação Física UEM/UEL	Hospital Universitário da Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7hf8jw	<NULL>	Be HIV-infected; make regular and correct use of ART for at least 1 year; do not present any motor impairment that affects the performance of tests and training; do not present any severe illness; not having been involved in the last 6 months with any physical exercise program; be older than 18 years.	Are using hormones, anabolic drugs or modulating immune therapy; present state of diarrhea, nausea, vomiting or poor oral intake of food; to present systemic infection in the 30 days before the beginning of the training; present current pregnancy or lactation; present state of advanced immunodeficiency and/or opportunistic infection; present some comorbidity that prevents the practice of exercise training; present any other contraindicated medical to the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-64vbk2	Dorsal musculature activity in undergraduate teachers	Data analysis completed	Intervention	2018-10-19	<NULL>	<NULL>	2291	Electrical activity of the paraespinal muscles in the flexion and extension of the column in teachers of the dynamic faculty	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-20	Faculdade Dinâmica do Vale do Piranga	Faculdade Dinâmica do Vale do Piranga	https://ensaiosclinicos.gov.br/rg/RBR-64vbk2	<NULL>	Be part of the staff of the Dynamic College of Piranga Valley and sign the Term of Consent Free and Clarified	Severe postural deviations; acute musculoskeletal dysfunctions; neurological changes; pregnancy; trauma to the lower back and menopause.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-2t54nx	Selective Removal of Carious in Primary Teeth using Laser: Assessment of Patient Anxiety and Performed Restorations	Data analysis completed	Intervention	2018-10-22	<NULL>	<NULL>	2295	Selective Removal of Caries Lesions using ER Laser:YAG in Primary Molars: Assessment of Patient Anxiety and Longitudinal Clinical Analysis of Restorations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-06	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-2t54nx	<NULL>	The inclusion criteria of the children were: two active caries lesions  in dentin; primary molars with pulp vitality; primary molars with absence of sealants; absence of amalgam restorations; absence of glass ionomer cement; absence of composite resin restorations.	First molars without pulp vitality; presence of sealants; presence of amalgam restorations; presence of glass ionomer cement; presence of composite resin restorations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-7q4sdy	Effects of Infrared and water exercise in patients with fibromyalgia	Data analysis completed	Intervention	2018-10-24	<NULL>	<NULL>	2297	Effects of an infrared emitting ceramic material and hydrokinesiotherapy in patients with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-24	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7q4sdy	<NULL>	Fibromyalgia Diagnostics; Female patients with FM (ages from 30 to 69) were selected from the Physiotherapy Clinic of the University of Southern Santa Catarina (UNISUL), Brazil.	Presence of active or previous neoplastic conditions, infection or making use of oral or local corticosteroids or anti-cytokine therapy that could influence cytokines serum levels. All of the participants were advised not to do any other regular physical activity outside the exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-5h4hht	Hunter-gatherers diet in the treatment of obesity	Data analysis completed	Intervention	2018-10-29	<NULL>	<NULL>	2303	Effect of paleolithic diet in the treatment of Obesity: controlled clinical trial and systematic review	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Fundação Universidade Estadual do Ceará - FUNECE	Fundação Edson Queiroz - Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-5h4hht	<NULL>	Excess weight; consent	Pregnant women; physical or cognitive limitations; bariatric surgery; thyroid disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9ptq49	Maternal vitamin D levels on modulation of maternal and newborn inflammation	Data analysis completed	Observational	2018-11-05	<NULL>	<NULL>	2311	Vitamin D status and repercussion in the modulation of NFkB pathway in placenta and in neonatal clinical and anthropometric parameters	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de São Paulo Campus Baixada Santista	Hospital Guilherme Álvaro	https://ensaiosclinicos.gov.br/rg/RBR-9ptq49	<NULL>	Healthy mothers; single fetus; submitted to normal delivery or cesarean; with no history of clinical or obstetric complications.	Chronic diseases and / or comorbidities; prematuriry; uterine abnormalities; fetal death; multiple birth; smoking, alcohol use and illicit drug use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-2sn8xv	Effect of individual sound amplification apparatus and/or Ginkgo blloba in tinnitus.	Data analysis completed	Intervention	2018-11-07	<NULL>	<NULL>	2317	Efficacy of the individual hearing aid x drug interaction with Ginkgo biloba in patients with Hearing Loss and Tinnitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Anhanguera de São Paulo	Clínica da Audibel Aparelhos Auditivos	https://ensaiosclinicos.gov.br/rg/RBR-2sn8xv	<NULL>	The inclusion criteria of the patients were: individuals over 18 years of age; complaint of tinnitus (uni or bilateral) for at least three months; (single or bilateral) sensorineural or mixed hearing loss independent of degree and configuration; both male and female were recruited.	The exclusion criteria of the patients were: have used aspirin or acetylsalicylic acid (ASA) in the last month; have used of Ginkgo biloba in the last three months; on antidepressant use; with compromised middle ear (otitis or tubal dysfunction) at the time of evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-794zhy	Effect of squatting posture on low back pain in adolescents and young adults	Data analysis completed	Intervention	2018-11-09	<NULL>	<NULL>	2328	Effect of squatting posture on the improvement of myofascial low back pain and body alignment in adolescents and young adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-06	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-794zhy	<NULL>	volunteers with chronic myofascial low back pain; age between 15 e 25 years; male and female	obese; pregnant women; wheelchair users; musculoskeletal disorders in the lower limbs; pelvic girdle and spine, such as fractures; trauma; surgery; scoliosis and kyphoscoliosis; congenital deformities in the lower limbs and spine; neurological diseases; individuals with cognitive deficits and performing physiotherapy treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-4s55nj	Ocular anesthetic comparison between vaporization and eyedrop instilation of tetracaina 1%.	Data analysis completed	Intervention	2018-11-09	<NULL>	<NULL>	2330	Tetracaine 1% anesthetic effect: comparison between eye drops in open eyes and spray in closed eyes	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade Estácio de Sá	Universidade Estácio de Sá	https://ensaiosclinicos.gov.br/rg/RBR-4s55nj	<NULL>	All the patients who came for ophthalmological consultation in Policlínica Ronaldo Gazolla -RJ from September 2017; invitations for patient participation in the study continued until the inclusion of 50 subjects.	Presence of any infectious or degenerative corneal disease; presence of disease affecting the trigeminal nerve, such as herpes zoster; patients who do not understand the research procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-6pxws7	The Impact of the Motivational Interview on the behaviors and conditions of individuals with disorders for the use of psychotropic substances  - a randomized clinical trial	Data analysis completed	Intervention	2018-11-09	<NULL>	<NULL>	2331	Motivational interview on oral health actions for psychiatric patients - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas	Secretaria Municipal de Saúde de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pxws7	<NULL>	adult individuals of both sexes; with at least 18 years of age; able to speak and understand the Portuguese language; diagnosed with alcohol use disorders (F.10); marijuana (F.12); cocaine / crack (F.14); ecstasy / LSD (F.16); use of multiple drugs (F.19); were followed up by a multiprofessional team of mental health from the Center for Psychosocial Care Alcohol and Drugs	individuals under the age of 18 and over 65, the edentulous, suffering from systemic diseases or severely decompensated psychoses, in addition to those who did not consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-2gkc7t	Effects of mirror therapy on the recovery of hand movements with partial loss of motor function in patients who suffered a stroke	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	2337	Effects of mirror therapy on the recovery of motor function from the paretic hand in  patients after stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Centro Universitário Maurício de Nassau	Centro Universitário Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-2gkc7t	<NULL>	Clinical diagnosis of Cerebral Vascular Accident; presenting kinetic-functional hemiparesis diagnosis; be between 40 and 70 years old; have sequelae time between 3 and 12 months; have preserved cognitive function.	Present another associated neurological disease; have sequelae of rheumatic, orthopedic, or vascular dysfunctions in the paretic hand; three consecutive sessions during the execution of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-98wgs8	The effect of Vestibular Rehabilitation on the balance of elderly women living in a long-term institution	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	2338	Efficacy of Vestibular Rehabilitation in the functional balance of institutionalized elderly women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Centro Universitário Maurício de Nassau	Centro Universitário Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-98wgs8	<NULL>	Women aged between 60 and 85 years; preserved cognitive function; accept to participate in the research.	Volunteers with presence of auditory and / or visual disturbances; use of wheelchair; with amputation and / or bed restriction; that we do not attend the treatment for at least three times without justification.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-3z7srd	Serial album for correct positioning during anesthesia during cesarean sections: clinical study	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	2341	Educational tchnology for the correct positioning in Spinal Anesthesia: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-12	Universidade Regional do Cariri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3z7srd	<NULL>	Pregnant aged 18 or over; With indication of cesarean section of gestation topical; with single fetus	Pregnant women who evolve with clinical or obstetric complications, who present some difficulty in understanding and verbal expression that prevents them from participating in the educational intervention or from responding to the instruments of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-64fx6x	Cross-Education in People with Parkinson’s Disease, a Short-Term Randomized Controlled Trial	Data analysis completed	Intervention	2018-12-01	<NULL>	<NULL>	2355	Effects of unilateral and bilateral training methods on motor control and strength in individuals with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-21	Universidade de Brasília	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-64fx6x	<NULL>	"Clinical diagnosis of PD by neurologist or physician according to the United Kingdom Parkinson&apos;s Disease Society Brain Bank criteria;
Modified Hoehn and Yahr Scale classification between stages 1 and 3;
No cognitive impairment as assessed by the Mini Mental State Examination (MMSE). The cut-off points for inclusion were &gt; 24 points for literate individuals and &gt; 19 for non-literate individuals;
Controlled hypertension (&lt;150/90 mmHg);
Do not have extreme obesity (&gt;40 Kg/m2);
Do not have a heart pacemaker;
Do not have amputation of upper or lower limbs;
Male and female volunteers from the Federal District;
Individuals between 40 and 80 years who do not have health problems and / or disabilities that prevent them from completing the test batteries and training program or who may have their problems aggravated due to participation in the program;
Availability to participate on activities proposed by researcher;
Have not practiced vigorous exercise at least 6 months previous."	"Any kind of trauma that prevents participation in the study;
Inability to perform any of the tests that are part of the research study;
Individuals who may voluntarily want to stop their participation in research; 
Individuals who do not have availability to participate in the research activities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-6wrxxh	Infusion of stem cells in people with Chronic Obstructive Pulmonary Disease: improvement of quality of life and physical performance.	Data analysis completed	Intervention	2018-12-03	<NULL>	<NULL>	2359	Autologous Stem Cell infusion in COPD patients: impact on quality of life and physical performance.	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-10-07	Faculdade de Medicina do ABC	IEP-São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-6wrxxh	<NULL>	patients aged between 40 and 70 years, of both gender, treatment optimized for COPD with grade 2 or 3 persistent dyspnea that is, they were all using beta 2 long duration associated with long-acting anticholinergic and inhaled corticosteroids, forced expiratory volume in the 1st second (FEV1) of 30-50%; possibility of being submitted to the pulmonary rehabilitation program; cessation of tobacco addiction for at least six months.	patients with: absence of emphysema on chest tomography; active pulmonary or extrapulmonary infection or history of infectious disease for less than 3 months; previous history of coronary artery disease and / or severe ventricular dysfunction; presence of pulmonary hypertension; home oxygen therapy; advanced or hepatic renal insufficiency; detected immunosuppressive or infectious diseases; carriers of known neoplasms and collagenoses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-738h37	Effects of Strength Training with Vascular Occlusion on the physical performance and pulmonary function of people with COPD	Data analysis completed	Intervention	2018-05-01	<NULL>	<NULL>	2367	Chronic effects of Strength Training with Blood Flow Restriction on the physical performance and pulmonary function of people with COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-738h37	<NULL>	Diagnostic of moderate or severe COPD (post-bronchodilatatior VEF1 between 30 and 60% of the predicted value); aging 50 years or more; clinicaly stable for at least a month before treatment (infections or acute exarcebations); non-smokers or ex-smokers for at least a year; without cardiovascular or orthopedic diseases that make impossible performing the exercises; being under medical treatment; have bachial-ankle index between 0.9 and 1.3, indicating that there is no risk of peripherical artery disease.	Will be excluded from the sample those who: exarcebate the disease during the treatment protocol; stop taking medication; present oxygen saturation smaller then 85% during exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-2g27rd	Clinical study with the choice of patients who present wounds and the use of natural latex insole associated with light emitting circuit of leds for light therapy	Data analysis completed	Intervention	2018-12-06	<NULL>	<NULL>	2369	Randomized clinical trial of patients with wounds: natural latex and led light emitting circuit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-05	Faculdade do Gama	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-2g27rd	<NULL>	Patients intellectually fit, with diabetes mellitus and affected by foot ulcers of neuropathic origin. With or without clinical signs of infection and after completing and signing a consent form	Pregnant women; under 18 years or over 75 years of age; with history of alcohol or drug abuse; with symptoms and diagnoses of osteomyelitis, local tissue necrosis; with cognitive, neurological, or latex hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-6vw9dv	Physiotherapeutic treatment in seamstresses with pain in the neck and shoulder.	Data analysis completed	Intervention	2018-12-10	<NULL>	<NULL>	2373	Physiotherapeutic approach in sewing machine operators with complaints in the cervical region and shoulder.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6vw9dv	<NULL>	Individuals of both sexes, who work in industry confections in the city of Araranguá, with chronic pain in the neck and shoulder.	Individuals with pain symptoms in the neck and shoulder do not perform 80% of the proposed treatment sessions, do not tolerate treatment, individuals with cognitive deficits or neurological patterns that may compromise the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-3fs2dm	Effect of Elastic Bandage on Hip Muscles, Trunk and Leg Movement, and Performance on Functional Testing in Healthy Women	Data analysis completed	Intervention	2018-12-12	<NULL>	<NULL>	2382	Effect of Dynamic Tape Functional Bandage on Gluteus Medius Muscle Function, and in Trunk and Lower Limb Kinematics and Functional Performance in Healthy Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3fs2dm	<NULL>	Female subjects; aged between 18 and 30 years old; belonging to the university community; who agreed to participate in the study; were previously enrolled in a Free and Informed Consent Term.	Presence of pain or signs characteristic of musculoskeletal dysfunction in the lower limbs and vertebral column; history of surgery and  or orthopedic dysfunction in the lower limbs in the last year; presence of cardiovascular or respiratory disease that impeded the performance of the study motions; presence of systemic or vestibular disease that affected the balance; presence of peripheral or central metabolic or neurological disease and; history of allergic reaction to the application of elastic bandages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5pdk45	Effects of an exercise program on the realignment of lower limbs of overweight and obese children: a randomized clinical trial	Data analysis completed	Intervention	2018-12-13	<NULL>	<NULL>	2385	Realignment of lower limbs in overweight and obese children: an eight week intervention program	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-5pdk45	<NULL>	Being overweight or obese; having between 7 and 9 years of age; returning the Free Consent Form signed by an adult; returning the Assent Form signed; being a student of the José Joaquim da Silva School.	Being present in less than 85% of the sessions; participating in sports activities other than Physical Education classes; being transfered from the school; refusing to perform the exercises in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-3s7t6p	Effect of the training of the musculature of the breathing and of the movement in the capacity to carry out activities in people who undergo coronary artery bypass surgery	Data analysis completed	Intervention	2018-12-17	<NULL>	<NULL>	2388	Effect of respiratory muscle training on the early functional capacity of individuals after myocardial revascularization surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal de Alfenas	Hospital Santa Lúcia de Poços de Caldas	https://ensaiosclinicos.gov.br/rg/RBR-3s7t6p	<NULL>	Volunteers with coronary artery disease; adults between 18 and 80 years; of both sexes.	Volunteers presenting with postoperative complications; with osteomuscular sequelae of stroke; osteomuscular sequelae that compromise the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-5rd2hx	Development of a diaphragm footbed for the treatment of wounds on diabetic feet based on a membrane with natural medicine	Data analysis completed	Intervention	2018-12-17	<NULL>	<NULL>	2390	Development of a Diabetic Foot Insole Derived from Natural Latex with Tissue Neoform Induction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade de Brasilia	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5rd2hx	<NULL>	Subject of the Regional Hospital of Taguatinga; of both sexes; age from 18 to 75 years; presenting diabetic foot ulcer of neuropathic and / or vascular origin with or without clinical signs of infection; who agree to participate and sign the TCLE (Informed Consent Form); with capacity to provide information about the tests and to collaborate with the project.	Pregnant; patient who drinks alcohol and / or drugs; evidence of osteomyelitis or gangrene somewhere on the affected extremity; topical application at the wound site after the start of the study that were not adopted in this protocol; present discomfort during the treatment application; patients who miss three consecutive times.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-95xwz8	Effect of alpha-lipoic in the control of acute pain and levels of biomarkers in surgery  of femur fracture	Data analysis completed	Intervention	2018-12-18	<NULL>	<NULL>	2394	Effect of alpha-lipoic acid as adjuvant in the control of acute pain and levels of biomarkers in surgery for correction of femur fracture	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto Doutor José Frota	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-95xwz8	<NULL>	Patients older than 18 years and less than 65 years of age, of both sexes, with physical status ASA I and ASA II according to the American Society of Anesthesiologists (ASA) Anesthetic Care Guidelines, scheduled for elective surgery in femur fracture correction	Volunteers who were hypersensitive to any of the drugs used in the study, who were pregnant, had kidney disease, coagulation disorder, puncture site infection, clinical signs of hypovolemia, who could not collaborate with the evaluation of postoperative analgesia and users of illicit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-786qk7	Electromyographic responses of posture differences through neurosensory stimuli	Data analysis completed	Observational	2018-12-18	<NULL>	<NULL>	2396	Analysis of the influence of visceral manual therapy on upper limb affections	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Católica de Pernambuco	Universidade Católica de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-786qk7	<NULL>	healthy individuals; of both sexes; are not subject to psychological treatment; agreed to participate in the study by signing the informed consent form	individuals who have some type of postural or balance deficit or have disorders of the vestibular system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-33hx6y	Pilates effects on the posture, balance and quality of life of Visually Impaired persons.	Data analysis completed	Intervention	2018-12-18	<NULL>	<NULL>	2397	Effects of a Pilates Mat protocol on the posture, balance and quality of life of the Visually Impaired of the Instito dos Cegos do Brasil Central- ICBC	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-33hx6y	<NULL>	PG – Individuals with visually impairment (Pilates intervention); CG – Individuals with visually impairment (no Pilates intervention); from the age of 18 to 59; both genders.	Individuals with a cognitive deficit; individuals who were reporting in the anamneses hearing or sensory deficiency, pathology in the labyrinth and individuals who were carrying out treatments and / or other physical activities that interference in the muscular force, flexibility and balance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-8tww4y	Treatment of women with Urinary Incontinence in Primary Care	Data analysis completed	Intervention	2018-12-19	<NULL>	<NULL>	2399	Implementation of Assistance to women with Urinary Incontinence in primary care	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-10-01	Universidade Federal de Minas Gerais	Prefeitura Municipal de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-8tww4y	<NULL>	Women from the local community; aged 18 years; had never received physiotherapy intervention for pelvic floor dysfunction.	Women who could not contract their PFM; were pregnant; presented symptoms of urinary infection; neurological disorders and/or difficulty understanding the treatment protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-8df2h4	Acupuncture treatment in elderly people with loss of muscle mass: effects on the strenght and inflammatory mediators	Data analysis completed	Intervention	2018-12-27	<NULL>	<NULL>	2409	Effects of acupuncture on the muscular strength of elderly patients with sarcopenia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-14	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8df2h4	<NULL>	male and female seniors; sedentary; who were not under acunpuncture treatment during the survey period.	Individuals who were afraid of needles; with mobility problems that prevented them to attend the data collection and processing location; who presented difficulties of understanding the treatment and the applied tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-3z5tbf	Clinical evaluation of restorations performed on tooth and outside the mouth using flexible die technique	Data analysis completed	Intervention	2019-01-01	<NULL>	<NULL>	2419	Clinical evaluation of direct and semidirect restorations using flexible die technique	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-03-07	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-3z5tbf	<NULL>	Class II restorations; oral hygiene properly; absence of parafunctional habits, systemic diseases, periodontal disease, removable protesis involving the tooth studied or antagonist; presence of antagonist tooth and adjacents.	Tooth sensitivity; Allergy to resin based on materials or other materials used in this study; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-2x2ntz	Evaluation of control of signs and symptoms of inflammation after third molar extraction	Data analysis completed	Intervention	2019-01-04	<NULL>	<NULL>	2422	"Evaluation of pain control, edema and trismus after third molar extraction
through two pharmacological regimens"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2x2ntz	<NULL>	"age between 18 and 35 years;
no systemic disease (ASA I);
not to use medications currently or in the previous week of the research;
To present the lower third molars in similar positions with similar patterns of root formation;
do not present allergy to the drugs used in the study;
To present surgical site without current signs and symptoms of infection"	"patients with a history of pregnancy or lactation; history of gastrointestinal bleeding or peptic ulcer;
allergy to aspirin or NSAIDS;
liver, kidney, haematological and central nervous system diseases;
continued use of psychoactive drugs, analgesics, steroidal and non-steroidal anti-inflammatory drugs and
smokers."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-9d94td	Effects of Judo Practice on Blood Pressure, Endothelial Response and Autonomic Control of Adolescents with Overweight and Obesity	Data analysis completed	Intervention	2019-01-07	<NULL>	<NULL>	2428	Effects of Judo Practice on Blood Pressure, Endothelial Response and Autonomic Control of Adolescents with Overweight and Obesity: A Randomized Controlled Trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-05	Universidade Estadual do Rio de Janeiro	Universidade do Porto	https://ensaiosclinicos.gov.br/rg/RBR-9d94td	<NULL>	Children and adolescents between 9 and 12 years of age are either eutrophic or overweight or obese.	Kidney disease. Hematologic disease. Liver disease. Rheumatological disease. Neurological disease. Cardiovascular disease. Respiratory disease. Infectious disease. Endocrine disease. Any type of health condition that may interfere in the evaluation of outcomes as well as contraindicate the practice of sports. Regular use of medications mainly for weight control. Participation in weight control programs through diet or exercise in up to six months before the start of the experiment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-22z3jy	Evaluation of the treatment with blood cells in patients with Behçet Disease	Data analysis completed	Intervention	2019-01-08	<NULL>	<NULL>	2433	Evaluation of the action of the treatment with platelet rich plasma in patients with Behçet Disease	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-22z3jy	<NULL>	Confirmed diagnosis of Behçet disease according to established criteria according International Study Group for Behçet Disease (ISGBD); Minimum recurrence of three episodes of disease activity in the last year; presence of oral/genital ulcers, without corticosteroid use or at most with 10 mg daily (prednisone).	The exclusion criteria were: involvement of the central nervous system and/or ocular picture in activity, hematological or renal alterations; antecedent of Neoplasia in the last 5 year; use of corticosteroids in daily doses above 10 mg and use of anticoagulants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-2ssg4w	Physical therapy for visually impaired people	Data analysis completed	Intervention	2019-01-10	<NULL>	<NULL>	2435	Physical therapy in visual impairment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-2ssg4w	<NULL>	Blind individual or individual with low vision; age between 18 and 59 years; cognitive autonomy assessed by the cut-off points of the Mini-Mental State Examination; and no neurological, cardiac or disabling musculoskeletal diseases.	Missing three or more consecutive sessions of physiotherapy and/or missing five sessions during the period of the protocol execution. Furthermore, participants who clearly had difficulties understanding the questionnaire at some point of the study were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-75kj6t	Study about the religiosity and quality of life in hypertensive people.	Data analysis completed	Observational	2019-01-10	<NULL>	<NULL>	2436	Perception of PSF Health Professionals regarding spiritual care from users	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-04-15	Centro Universitária Adventista de São Paulo	Centro Universitária Adventista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75kj6t	<NULL>	Be enrolled in the Basic Health Unit; be over 18 years old; have no other diseases besides hypertension.	Have cognitive deficit; have diabetes; not be enrolled in the Primary Health Care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-4bdrc9	Evaluation of microbial contamination of aesthetic orthodontic ligatures by using a molecular biology technique	Data analysis completed	Intervention	2019-01-11	<NULL>	<NULL>	2440	Microbial contamination profile on aesthetic elastomeric ligatures through the checkerboard DNA-DNA hybridization technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-02	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4bdrc9	<NULL>	Patients with good general and dental health; aged between 11 and 25 years; in orthodontic treatment and without having used mouthwashes in the last 3 months	Patients with some type of systemic disease; with poor dental health as presence of dental caries, periodontal disease; or who regularly use mouthwashes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-4sspn6	The use of Breast Milk compared to Glucose to reduce Pain during Collection of Examination in preterm infants	Data analysis completed	Intervention	2017-08-15	<NULL>	<NULL>	2443	Analgesic effect of Maternal Milk versus 25% Glucose during the collection of Arterial Blood Gases in preterm newborns: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Maternidade Escola Assis Chateaubriand-MEAC	Maternidade Escola Assis Chateaubriand-MEAC	https://ensaiosclinicos.gov.br/rg/RBR-4sspn6	<NULL>	All clinically stable preterm NBs were considered eligible; Regardless of gestational age (GI); Weight greater than or equal to 500 g and with a minimum; 12 hours of life and hospitalized in high risk beds in Neonatal Intensive Care Units; Making use of some form of oxygen therapy; Since most of these patients have respiratory disorders and require oxygen to improve the clinical picture. All the newborns submitted to the procedure of collection of arterial blood gases by clinical indication and medical prescription were also included in the study.	Newborns less than 12 hours old were excluded; Due to hemodynamic and respiratory instability. As a consequence, neonates with clinical instability were also excluded; The malformed ones; Children of chemical dependents; Women seropositive for the Human Immunodeficiency Virus (HIV); Neonates who have undergone recent surgical procedures; Those who have been using sedation or analgesia (fentanyl or dormonid); Those with neurological manifestations; Such as convulsions and the children of mothers with psychiatric problems; Due to the use of some medications contraindicated for breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-9xdn2y	Influence of the nervous system on heart rate and functional capacity after supervised physical training in patients with high blood pressure: a pilot study	Data analysis completed	Intervention	2019-01-18	<NULL>	<NULL>	2449	Autonomic heart rate modulation and functional capacity in hypertensive patients before and after supervised non-exhaustive aerobic physical training: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Fundo de Apoio ao Ensino, à Pesquisa e à Extensão – FAEPEX, Universidade Estadual de Campinas – Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-9xdn2y	<NULL>	Participants who met the following inclusion criteria were considered eligible for inclusion in the study: hypertensive patients classified in stages 1, 2 and 3 (Stage 1: SBP between 140-159 mmHg and / or DBP between 90-99 mmHg; Stage 2: PAS between 160-179 mmHg and / or PAD between 100-109 mmHg and Stage 3: SBP ? 180mmHg and / or PAD ? 110 mmHg) according to the VI Brazilian Guidelines for SAH; patients rated with very weak and reasonable physical fitness according to American Heart Association criteria, which uses the maximum oxygen consumption (ml / kg / min) for classification.	Participants who presented one of the following conditions were: non-verbal communication; Grade III obesity, ie, Body Mass Index (BMI)&gt; 40kg / m2; patients with a history of coronary disease classified as moderate to high risk (classes C and D) for physical training according to the American Heart Association criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-4q38c8	Subtenon Block with Ropivacaine and Bupivacaine in Cataract surgery	Data analysis completed	Intervention	2019-01-23	<NULL>	<NULL>	2454	Ropivacaine versus Racemic Bupivacaine in Episcleral Block for Phacoemulsification Facectomies: double-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Hospital Alberto Rassi - HGG	Fundação Banco de Olhos de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4q38c8	<NULL>	Volunteers aged between 18 and 75 years; physical status I or II according to ASA (American Society of Anesthesiologists) criteria; both sexes; candidates for phacoemulsification facectomy surgery and intraocular lens implantation with episcleral block	Volunteers with known allergy to local anesthetic; glaucoma patients; abnormal eye movement; chronic cough; anticoagulant therapy; orbital abnormalities; inability to understand study information; block failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-4mhs32	The role of Vitamin D on metabolic and immunology profile of postmenopausal women	Data analysis completed	Intervention	2017-06-05	<NULL>	<NULL>	2457	The role of Vitamin D on cardiometabolic and immuno-inflammatory profile of postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-05	Faculdade de Medicina de Botucatu - UNESP	Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-4mhs32	<NULL>	Last menstrual period for at least 12 months, age greater than or equal to 45 years old who accept participate and vitamin D deficiency	DAC manifest presence of current or past; Cerebrovascular arterial disease; aneurysmal disease; peripheral arterial disease; chronic kidney disease; insulin dependent diabetes; liver disease; autoimmune diseases; alcoholic or drogaditas; use of pharmacological doses of VD	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-67vp85	Efficacy of medicinal plant Aloysia for anxiety symptoms	Data analysis completed	Intervention	2019-01-24	<NULL>	<NULL>	2458	Efficacy of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in anxiety symptoms	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-01-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Universidade de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-67vp85	<NULL>	Age between 18 and 60 years; HAM-A score of at least 18 points; No history of allergy to A. polystachya or its components or to plants from Verbenaceae family; No use of psychotropic drugs; Not in psychiatric treatment; Not have used psychotropic medicines within 2 weeks; Not be smoker; Not be heavy drinker.	Patient&apos;s request; Allergy or adverse reaction attributable to the plant; Any alcohol use within 1 week or during study; Any psychotropic drug use within 1 week or during study; Any psychiatric treatment within 1 week or during study; Smoking within 1 week or during study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-5dy35n	Evaluation of polysomnography data in the treatment of sleep respiratory disorders with intraoral language stabilization device: randomized clinical trial	Data analysis completed	Intervention	2019-01-24	<NULL>	<NULL>	2459	Evaluation of polysomnographic parameters in the treatment of sleep-disordered breathing with tongue stabilizer: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-03-03	Universidade Federal de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dy35n	<NULL>	patients with a polysomnographic diagnosis of mild or moderate OSAS; and who did not adapt or had no access to CPAP treatment	patients on drug treatments that may modify muscle tone; alcohol users in their daily routin;, involved in any other type of treatment for OSA; or patients who were pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-6wrv5y	Effectiveness of the addition of pectoral stretching in patients with subacromial impingement syndrome: a clinical trial.	Data analysis completed	Intervention	2018-04-10	<NULL>	<NULL>	2461	Effectiveness of adding pectoralis minor stretches to an exercise program in patients with subacromial impingement syndrome: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	CDT Hospital San Borja de Arriaran	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-6wrv5y	<NULL>	Included:Patients over 18 years of age referred from the Adult Orthopedist Department with a clinical and imaging diagnosis of SIS type II; Who accepted and signed the informed consent.	Excluded;Patients who presented pathologies of cervical origin cervical such as radiculopathy; or other pathologies of the shoulder joint complex such as osteoarthritis in the acromioclavicular or glenohumeral joints, calcific tendinitis, adhesive capsulitis, glenohumeral instability; partial or full-thickness tear rotator cuff; etc;patients who have had history of acute trauma;previous surgery or previous fracture in the affected shoulder, patients who have had corticoid infiltration in the affected shoulder in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-7sx8j3	The effect of visceral manipulation in patients with chronic non-specific low back pain assessed during the anterior trunk flexion movement	Data analysis completed	Intervention	2017-10-30	<NULL>	<NULL>	2463	The effect of 6-weeks Osteopathic Visceral Manipulation on the flexion-relaxation phenomenon in patients with nonspecific chronic low back pain: a protocol of randomized placebo-controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-20	Associação Educacional Nover de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-7sx8j3	<NULL>	Age 18 to 65 years; nonspecific low back pain for at least 3 months; pain intensity of at least 2 points as measured with 0 - to 10 - point Pain Numerical Rating Scale; functional constipation according criterias to Rome III.	"Patients with any contraindication to osteopathic visceral manipulation or that submitted to treatment at least 6 months ago. previous spine surgery within the preceding 6 months;  serious spinal pathology (e.g., metastasis, spinal fracture, inflammatory, and infective diseases, caudal equine syndrome, canal stenosis);
Serious cardiovascular or metabolic diseases; pregnancy; red flags signals; nor currently in an acute inflammatory phase of known gastrointestinal or urinary diseases (such as cholecysticis, renal calculi, peritonitis, appendicitis)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-89kchg	Benefits of traditional, functional and calisthenic training in physical fitness, cardiovascular health and quality of life of the elderly	Data analysis completed	Intervention	2019-02-05	<NULL>	<NULL>	2467	Influence of Traditional, Functional and Calisthenic Training on Physical Fitness, Cardiovascular Health and Quality of Life in Older Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-29	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89kchg	<NULL>	Be physically independent; Be 60 years of age or older; Do not present medical history of heart disease, musculoskeletal disorders, diabetes, uncontrolled hypertension or any other dysfunction that restricts the practice of high intensity physical exercises; Do not use hormone therapy medications, lipid-lowering agents, hypoglycemic agents and anti-inflammatories	Regular participation in systematic exercise programs in the three months prior to the present study; Presence of uncontrolled cardiovascular and musculoskeletal diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-9hspyy	Fluoride present in toothpaste as an indicator of its availability in saliva	Data analysis completed	Intervention	2019-02-06	<NULL>	<NULL>	2469	Chemically soluble fluoride found in toothpaste as a predictor of fluoride bioavailability in saliva	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-9hspyy	<NULL>	"Good general and oral health;
Salivary flow unstimulated within normalities."	"Participants using orthodontic appliances;
Participants who use medications that affect the salivary flow."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-6c7tns	Effects of active exercises on fibromyalgia	Data analysis completed	Intervention	2019-02-12	<NULL>	<NULL>	2477	Effects of a postural orientation program in patients with Fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6c7tns	<NULL>	"Women aged 30-55 years; fulfillment of the
American College of Rheumatology 1990 or 2010 criteria for diagnosis of FM [3]; residence in the metropolitan area of Recife, PE; stable psychological, physical, and drug therapy in the preceding month."	Patients attending physiotherapy sessions, using gait assistance devices, suffering from associated autoimmune rheumatic diseases, or presenting uncontrolled comorbidities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-9pbvnm	Evaluation of the efficacy of a low cost Model for superficial vein access using ultrasound	Data analysis completed	Intervention	2019-02-12	<NULL>	<NULL>	2479	Evaluation of the efficacy of a Non-Human Experimental Model  for  superficial venous Puncture guided by ultrasound	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Faculdade de medicina do ABC	Faculdade de medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-9pbvnm	<NULL>	Nurses of the clinical body of the teaching hospital Padre Anchieta. Patients hospitalized at the Padre Anchieta Teaching Hospital; with medical indication of peripheral venous access; over 18 years old; with superficial vein in the upper limbs; with gauge greater than 0.35 cm and up to 1.5 cm deep; signature of the free and informed consent form.	Failure to accept and sign the informed consent form; Under 18; Greater than 90 years; There is no superficial vein in the upper limbs, with a caliber greater than 0.35 cm and up to 1.5 cm deep (distance between the anterior wall of the vein and the skin).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-62wvhp	A randomized clinical study using Mta for Endodontic Treatment as a material in milk teeth	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2485	Randomized clinical assay of use the Mta in Pulpar Therapy of deciduous teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Angelus Industria de Produtos Odontológicos S/A	CCS - COU - Programa de Pós-Graduação em Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-62wvhp	<NULL>	Healthy children;molar teeth with deep carious lesion;provoked and non-persistent pain;maximum root resorption of up to 2/3 root;restorative tooth;tooth that allows absolute isolation	Primary molars with percussion sensitivity, spontaneous and persistent pain, interradicular bone loss, internal resorption, less than 2/3 of root, edema, fistula, abscess, pulp calcifications, pathological mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7v6r3t	Effect of exercises to mobility in the orofacial musculature in volunteers with temporomandibular dysfunction: brain function	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2486	Effect of isotonic exercises in the orofacial musculature in volunteers with temporomandibular dysfunction: neurophysiological	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-30	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7v6r3t	<NULL>	Age between 18 and 60 years old; temporomandibular disorder muscular diagnostic reach by research diagnostic criteria; pain between 4 and 10 in numeric scale.	Displacement of the temporomandibular joint; arthralgia; osteoarthrosis; osteoarthritis; advanced neurological and psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-4dc5yc	Comparison of High Fidelity Simulator versus Dramatization: impact on satisfaction, self-confidence and knowledge of nursing students	Data analysis completed	Intervention	2019-02-19	<NULL>	<NULL>	2487	High Fidelity Simulator x Dramatization: impact on satisfaction, self-confidence and knowledge of Nursing students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Escola de Enfermagem de Ribeirão Preto - USP	Universidade do Oeste Paulista - UNOESTE	https://ensaiosclinicos.gov.br/rg/RBR-4dc5yc	<NULL>	"Students regularly enrolled in the 3rd and 4th year of the undergraduate nursing course.
Older than 18 years;"	Failure to comply with the study steps.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-6msdqt	Changing the traumatized patient&apos;memory with Prolonged Exposure Therapy	Data analysis completed	Intervention	2019-03-04	<NULL>	<NULL>	2509	Post-exposure retrieval in the traumatized patient	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-15	Fundação de Amparo à Pesquisa do Estado de São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6msdqt	<NULL>	Meet the DSM-IV criteria for PTSD according to the Structured Clinical Interview for DSM Axis I Disorders, Patient Edition (SCID-I/P); being able to report the traumatic event; have emotional reactivity to trauma recall, defined as a minimum score of 40 in the Visual Analogue Scales (VASs) after describing the traumatic event; have regular menstrual cycle (female patients who were then tested in the follicular phase, defined as the first half of their usual cycle) or were taking hormonal contraceptive.	Patients were excluded if they had any medical condition that could threaten their safety, such as heart or neurological conditions, or current suicide risk; fulfill criteria for bipolar, psychotic, or substance use disorders; were in use of medications known to affect memory reconsolidation or extinction, such as beta-adrenergic blockers, benzodiazepines and anticonvulsants; current pregnancy; and previous participation in another study that could affect the present one.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-68bwkc	Application of antimicrobial gel aiming to treat periodontal disease (gingival disease)	Data analysis completed	Intervention	2018-09-14	<NULL>	<NULL>	2510	Clinical evaluation of metronidazole semi-solid and film-forming formulations for the treatment of periodontal disease	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2015-05-05	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-68bwkc	<NULL>	Chronic periodontitis with a clinical insertion level equal to or greater than 5 mm in two or more teeth and depth of probing equal to or greater than 5 mm in one or more periodontal sites (MACHTEI et al., 1992); age range from 35 to 70 years; not have used antibiotics for at least 3 months; absence of history of allergy to the components present in the formulations tested.	"Volunteers with severe cardiovascular disease;
volunteers with problems related to pharmacokinetics, such as nephropathies, liver diseases, etc."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-75h3nz	Effects of scapula exercises in patients with Fracture of the distal radius	Data analysis completed	Intervention	2018-02-06	<NULL>	<NULL>	2514	Effectiveness of adding scapular control exercises to kinetic treatment in patients with distal radius fracture: Randomized simple-blind clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidad de las Americas	CDT Hospital San Borja de Arriaran	https://ensaiosclinicos.gov.br/rg/RBR-75h3nz	<NULL>	subjects over 60 years of age derived from the Adult Traumatology Service of the San Borja Arriarán Clinical Hospital, with a medical diagnosis of multifrectional extraarticular type FRD according to the AO classification, treated conservatively with closed reduction plus immobilization with plaster. Subjects that accept and sign informed consent.	Subjects presenting some immediate complication after removal of immobilization , painful regional complex type I, carpal tunnel syndrome, etc. subjects presenting a shoulder pathology diagnosed at least 1 year before the occurrence of the DRF, subacromial pinching syndrome, partial or total rupture of the rotator cuff, glenohumeral instability, adhesive capsulitis, etc.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-3vzvbx	Effectiveness of Atraumatic Restorative Treatment (fillings) and Ultra Conservative Treatment (brushing) for Dental caries in children	Data analysis completed	Intervention	2019-03-13	<NULL>	<NULL>	2518	Effectiveness and acceptance of Atraumatic Restorative Treatment (ART) and Ultra Conservative Treatment (UCT) for Dental caries in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-11-08	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3vzvbx	<NULL>	Children from first to fourth year at elementary school; 4 to 9 years-old; presenting at least one primary molar with cavitated dentin caries.	Non cooperative children; children using fixed orthodontic appliance; teeth with any sign of pulp involvement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5hncs9	Evaluation of the effects of Elastic Stockings on quality of life and prevention of Swelling in the Lower Limbs of hairdressers after a working day	Data analysis completed	Intervention	2019-03-13	<NULL>	<NULL>	2520	Evaluation of Elastic Stocking in quality of life and prevention of Occupational Edema in hairdressers	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-25	Faculdade de Tecnologia e Ciências - FTC	Faculdade de Tecnologia e Ciências - FTC	https://ensaiosclinicos.gov.br/rg/RBR-5hncs9	<NULL>	Prolonged standing period (on average 8 hours); women; accept participating in the study; belong to classes C0 and C1 in the CEAP classification	Disagree in participating in the study; being in use of medication that could influence the formation of lower limb edema; cardiac insufficiency; renal insufficiency; hepatic insufficiency; thyroid disease; rheumatic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-649bhb	Effectiveness Evaluation of a Comprehensive Care Model in Oral Health for Pregnant Women in Gestational Outcomes: Randomized Clinical Trial	Data analysis completed	Intervention	2019-03-14	<NULL>	<NULL>	2523	Validation of a Comprehensive Care Model in Oral Health for Pregnant Women and Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-649bhb	<NULL>	"Pregnant women registered in e-sus of the municipality&apos;s Basic Health Units in the study;
Have time to participate in the meetings determined during the research;Be in the first trimester of pregnancy (0 to 13 weeks) or in the first prenatal visit of the second trimester (14 to 26 weeks) during the recruitment period;Be accompanied by the Family Health team (eSF) during prenatal care at UBS."	Pregnant women with psychiatric problems;Pregnant women with HIV and / or autoimmune diseases;Pregnant women who use illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-7n496r	Effect of acute consumption of juçara juice in damage indicators caused by free radicals and inflammation before and after exercise and the relation with depressive symptoms and anxiety	Data analysis completed	Intervention	2019-03-15	<NULL>	<NULL>	2525	Effect of acute consumption of juçara juice (Euterpe edulis Martius) in oxidative stress biomarkers and inflammatory profile before and after a high-intensity interval exercise session and the relation with depressive symptoms and anxiety: a randomized single-blind cross-over trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-7n496r	<NULL>	Male; age between 19 and 30 years; and physically active	Sedentary individuals; smokers; carriers of any diseases, visible or known inflammatory or infectious processes; muscleskeletal injuries in the last 3 months; users of vitamin and mineral supplements, ergogenic resources (carnitine, arginine, creatine and caffeine), anabolic steroids or medications in the month prior to the interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-9y4z7z	Use of troat pack in orthognathic surgery	Data analysis completed	Intervention	2019-03-19	<NULL>	<NULL>	2529	Efficacy of Oropharyngeal pack in Orthognathic surgery - doble-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-13	Universidade de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-9y4z7z	<NULL>	"Age between 18 and 60 years;
Climbing orthognathic surgery of the jaws;
Physical state (ASA) I or II;
That you have a chance to leave your study participation;"	"• Previous history of nausea and vomiting;
• Previous history of motion sickness and migraine;
• Difficulty in tracheal intubation;
• When it was not possible to collect the data or to apply the proposed methodology;
• Allergy to the drugs proposed in this study;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-9w5p8q	Clinical evaluation of restorations using a new resin composite	Data analysis completed	Intervention	2019-03-20	<NULL>	<NULL>	2530	Clinical Evaluation of Class II restorations using a composite resin containing the ormocer monomer. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia da Universidade Estadual Paulista de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-9w5p8q	<NULL>	Class II restorations; oral hygiene properly; absence of parafunctional habits, systemic diseases, periodontal disease, removable protesis involving the tooth studied or antagonist; presence of antagonist tooth and adjacents.	Tooth sensitivity; Allergy to resin based on materials or other materials used in this study; Pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-5f6zw4	Temporomandibular joint disorder: structural changes, function and causal factors	Data analysis completed	Observational	2019-03-20	<NULL>	<NULL>	2531	"Temporomandibular disorder: morphological, functional alterations and factors
etiological"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Universidade Estadual de Ponta Grossa	Faculdade Guairacá	https://ensaiosclinicos.gov.br/rg/RBR-5f6zw4	<NULL>	Women 18 to 40 years old who reported at least one (1) of the following signs and symptoms: Referred pain in the temporomandibular joint and / or associated musculature (at least 1 episode in the last 3 months); Limitation or restriction of opening or lateralization of the mouth (lateral excursion) (at least 1 episode in the last 3 months); Pain reported in the mouth opening (at least 1 episode in the last 3 months); Sounds in the joint without pain, but with a recent episode (or at least 1 episode in the last 3 months) of pain or limitation of mouth opening; Sounds in the joint without the presence of pain, but with severity enough to cause concern to the patient or make him seek treatment; Women seeking treatment for temporomandibular dysfunction with confirmed diagnosis; Women with diagnosis of temporomandibular dysfunction, obtained by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC / TMD) Axes I and II.	History of facial traumas; history of facial neoplasms; history of facial surgeries; cognitive alterations; neurological changes; use of auxiliary devices for walking and locomotion; presence of rheumatic disease; presence of physical disability; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-84r7t9	The autonomic balance in asthmatic children	Data analysis completed	Intervention	2019-03-21	<NULL>	<NULL>	2537	The autonomic nervous system in asthmatic children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Programa de Pós-graduação em Ciências da Saúde- PPGCS-FURG	Hospital Universitário Dr. Miguel Riet Corrêa Jr. - HU-FURG	https://ensaiosclinicos.gov.br/rg/RBR-84r7t9	<NULL>	"We included all children aged 7
and 18 years old and diagnosed with asthma, attended at the Pneumology outpatient clinic
Pediatric Hospital of the University Hospital of the Federal University of Rio Grande (FURG), in the period between December 2015 and November 2016."	Patients with a diagnosis of bronchopulmonary dysplasia; cystic fibrosis; congenital cardiopulmonary diseases; immunodeficiency; chronic encephalopathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-7g6qq8	Comparison of the effects of oral and intramuscular use of corticosteroids on pain, swelling and mouth opening and closing movements after extraction of the wisdom tooth	Data analysis completed	Intervention	2019-03-25	<NULL>	<NULL>	2539	Comparative study of the effectiveness of two routes of corticosteroid administration to control edema, trismus and pain after surgical extraction of impacted third molars	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-27	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7g6qq8	<NULL>	The inclusion criteria were: healthy subjects, aged over 16 years of either sex, without contraindications for corticoid treatment, no history of pericoronitis for the last 6 months, no history of recent illness that required medications that could alter the inflammatory response, no use of medication that could interfere with the healing process and who required extraction of all four third molars. The extractions were all of similar technical difficulty and orthopantomography showed positioning and depth of impaction to be symmetrical in each arch. All patients required ostectomy and tooth sectioning of the lower third molar to achieve extraction. The difficulty was determined by means of the Pell and Gregory classification.	"Occurrence of post-operative local infection
 Failure to attend second surgical procedure"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-3tknxy	Influence of lemon on the inflammatory activity of healthy women during menstruation	Data analysis completed	Intervention	2019-03-25	<NULL>	<NULL>	2540	Influence of cytotherapy on prostaglandin production in healthy women during menstruation	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2016-06-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3tknxy	<NULL>	Healthy women aged 18-40 years who signed the informed consent form	"Women who used some type of hormonal contraceptive, with a history of gynecological diseases, immunodeficiency, autoimmune diseases, malignant neoplasms or history of chemotherapy or radiotherapy.
Women who practiced intense physical activity or recently modified their physical activity patterns.
Women who used chronic drugs such as non-hormonal anti-inflammatories, immunosuppressants, anxiolytics or antidepressants, or who used some type of medication in the 15 days prior to the start of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-9tpwc5	The effect of Conventional Transcutaneous Electric Nerve Stimulation (TENS) for treatment of Migraine crisis	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	2546	The effect of Conventional Transcutaneous Electric Nerve Stimulation for treatment of Migraine crisis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-10	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9tpwc5	<NULL>	"The selection of patients will be carried out based on electronic medical record research and routine consultations in the head and face ambulatory, following the &quot;Guidelines for clinical trials of drug in migraine&quot; (IHS, 2012). Patients with a diagnosis of primary headache classified as migraine will be included; And the major subtypes: migraine with aura and migraine without aura; (ICHD-III, 2013), respecting the following criteria:

Migraine without aura: recurrent cephalic disorder in at least five episodes with the following characteristics: duration of 4 to 72 hours, unilateral, pulsatile, moderate or severe intensity, aggravation by routine physical activity and association with nausea and / or photophobia and phonophobia ;Migraine with aura: at least five episodes with features of migraine without aura and preceded or accompanied by neural symptoms. The typical aura occurs from 5 to 60 minutes duration before the onset of pain, unilateral and completely reversible, with visual, sensory or other central nervous system symptoms that usually develop gradually and are usually followed by Headaches with migraine characteristics and associated symptoms. It can be of six different types, namely retinal aura, visual aura, sensory-somesthetic aura, motor aura, aphasic aura and brainstem aura.
The study will invite patients of both genders, aged between 18 and 65 years, age at onset of illness less than 50 years, diagnosed with migraine for at least one year before being recruited to participate in the study. All should be in current treatment with the use of recommended medicines, in stable doses for at least 30 days and that present sporadic crises.The use of these recommended drugs in the literature and guidelines for the prevention of migraine will occur in conventional doses. All predicted classes of drugs may be employed, namely: calcium channel blockers, such as nimodipine, beta-blockers, such as propranolol and atenolol; Tricyclic antidepressants, such as amitriptyline and nortriptyline; And, among the anticonvulsants, only topiramate and sodium valproate. The frequencies of migraine attacks (with the use of the recommended treatment and in stable doses) should be 1 to 6 times a month, with a remission period of at least 48 hours (IHS, 2012)."	"Patients with the following criteria will be excluded from the sample: Physical or intellectual incapacity to respond to the survey questionnaire, illiterate, diabetic, pacemaker, epileptic, users of illicit substances and those diagnosed with other CNS diseases (IHS, 2012). Other classifications of migraine, such as chronic migraine (over 15 days with headache / month) and overuse of medications, eg, more than 10 days in the use of triptans for acute pain (IHS, 2012).
Ethical patients, ie the acceptable consumption of alcoholic beverages is up to 15 doses / week for men, not exceeding three daily doses and 10 doses / week for women, no more than two doses per day (WHO, 2004)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-7g4dhr	Effect of physical exercise for the muscles of respiration in the body&apos;s defense system in the elderly	Data analysis completed	Intervention	2019-03-28	<NULL>	<NULL>	2558	Effect of Respiratory Muscle Training on the Immune Response in the elderly	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação de Amparo a Ciência e Tecnologia de Pernambuco	Fundação de Amparo a Ciência e Tecnologia de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7g4dhr	<NULL>	Adults older than 65 years of age; of both sexes; who lived in healthy nursing homes and who agreed to participate in the study by signing the ICF.	Elderly patients who did not understand some of the steps of the proposed protocols; with a body mass index above 35 mL / kg²; or with some degree of orthopedic or neurological limitation that made the tests impossible were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-78nwbg	Effects of an online social network on promoting and supporting breastfeeding	Data analysis completed	Intervention	2016-12-27	<NULL>	<NULL>	2569	Effects of an intervention to promote and support for breastfeeding through social maternal online network	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-08	Hospital Universitário Lauro Wanderley	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-78nwbg	<NULL>	Mothers in the postpartum period that use the online social network Facebook; can read and write.	Illiterate mothers; under the age of 18;  seropositive for HIV or other diseases that contraindication to breastfeeding; premature fetuses; low weight; twin; congenital problems to prevent suckling at the breast.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-4n3vwg	Effect of the electrical stimulation of the skin and heated thermal bag in normal labor	Data analysis completed	Intervention	2019-04-08	<NULL>	<NULL>	2586	Physiotherapy assistance in labor: the influence of transcutaneous electrical stimulation and the heated thermal bag during normal labor	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Centro Universitário de Barra Mansa	Hospital São João Batista	https://ensaiosclinicos.gov.br/rg/RBR-4n3vwg	<NULL>	Term, primiparous and multiparous women with ages ranging from 18 to 40 years, with 3 to 4 centimeters of uterine cervix dilatation, without analgesic and / or anesthetic drugs, with preservation of tactile sensitivity and cognition, were included in the study. medical authorization to perform the physiotherapy, without any complications, and who accepted to be part of the study after reading the ELCT	Pregnant women less than 18 years of age, with elective cesarean sections, with pacemakers, with some complications during labor, with morbidities such as diabetes, arterial hypertension or preeclampsia, with cognitive deficit, hypersensitivity to heat, reduced tactile sensitivity, without medical authorization to receive physical therapy and who did not agree to be part of the study after reading the ELCT	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-6bcj43	Identification of cardiovascular risk factors in children	Data analysis completed	Observational	2019-04-09	<NULL>	<NULL>	2589	Characterization of cardiovascular risk factors and profile of cardiac autonomic modulation in school-age children	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-20	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6bcj43	<NULL>	Children 6 to 10 years of age who do not use medicines that influence the autonomic activity of the heart and that do not carry previously diagnosed respiratory or metabolic diseases.	Children who present series of RR intervals with error greater than 5%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-8dyc7g	"Recruitment and flexibility of column muscles:
an evaluation of the effects of muscle release"	Data analysis completed	Intervention	2019-04-11	<NULL>	<NULL>	2592	Muscle recruitment and flexibility of spinal erectors: an evaluation of the effects from the Myofascial Release Technique	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-8dyc7g	<NULL>	students from the University; aged 18-35; both sexes	Participants who performed some physical activity in the 6 months prior to the survey; with diagnosis of any musculoskeletal lesions; significant postural deviations; pregnant or in the menstrual period; such as individuals who used generic anti inflammatory drugs during data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-3jhb3t	Use of a list of recorded words to analyze speech comprehension in children using cochlear implants	Data analysis completed	Observational	2019-04-15	<NULL>	<NULL>	2598	Use of the list of recorded words for evaluation of speech perception in children using cochlear implants	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-19	Hospital de Reabilitação de Anomalias Craniofaciais - HRAC/USP	Universidade de São Paulo - USP	https://ensaiosclinicos.gov.br/rg/RBR-3jhb3t	<NULL>	Healthy children; both genders; age between five years to 10 years and 11 months; with typical hearing and language development	Children with hearing impairment and oral language disorders or other associated comorbidities were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-6gx9y3	Effect of aquatic exercises on the health of patients with rheumatoid arthritis	Data analysis completed	Intervention	2019-04-16	<NULL>	<NULL>	2600	Effect of hydrokinesitherapy on anxiety, depression and quality of life in patients with Rheumatoid Arthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade do Estado de Santa Catarina	Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPQ	https://ensaiosclinicos.gov.br/rg/RBR-6gx9y3	<NULL>	Female volunteers; Clinical diagnosis of rheumatoid arthritis; Present attestation that are suitable for the practice of aquatic activities; Age above 18 and with the disease in activity.	Lack of time to participate in the program, Physical incapacity to perform the physical exercise program, Heart disease or severe pulmonary disease; Resting systolic blood pressure above 180 mmHg, Dermatological problems, Urinary and / or fecal incontinence, Change medication or initiate another type of therapeutic intervention during the 12 weeks of the study and do not adapt to the aquatic environment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-345m6j	Nitric Oxide Generator device for the treatment of Pulmonary Hypertension	Data analysis completed	Observational	2019-04-17	<NULL>	<NULL>	2603	Nitric Oxide Generator for newborn Pulmonary Hypertension, a portable bedside device	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-09-09	Hospital de Clínicas	Consejo Nacional de Innovación, Ciencia y Tecnología (CONICYT)	https://ensaiosclinicos.gov.br/rg/RBR-345m6j	<NULL>	Written parental consent to receive the proposed therapy; newborns greater than 34 weeks of gestational age; diagnostic of severe refractory hypoxemia receiving conventional intensive care supporting treatment; no access to any other kind of inhaled Nitric Oxide therapy; oxygenation index over 10; pre and post-ductal difference in pulsioximetry equal or over 5	Neonates with multiple malformations or malformations incompatible with extra uterine life. Lack of parental consent to receive the proposed therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-2vz89f	Study of microcirculation in Leprosy	Data analysis completed	Observational	2019-04-17	<NULL>	<NULL>	2605	Study of microcirculation in Leprosy using polarized orthogonal light (Microscan®)and laser-Doppler associated to iontophoresis: A model of dysautonomy by denervation	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-20	Universidade do Estado do Rio de Janeiro	Fundação Carlos Chagas Filho de Amparo À Pesquisa do Estado do Rio de Janeiro (FAPERJ)	https://ensaiosclinicos.gov.br/rg/RBR-2vz89f	<NULL>	"Male;
Be a tuberculoid leprosy patient under treatment;
Age between 20 and 60 years;
Present tuberculoid lesion in skin of superior and inferior limbs;
Do not have hypertension or Diabetes mellitus and other diseases that may alter microcirculatory parameters;
Do not be a smoker;
Do not present leprosy reaction state at the time of the examination;
Ability to follow the given guidelines and attend the evaluations;
Phototype I-IV of Fitzpatrick and
Sign the informed consent form."	"Obesity (BMI&gt; 35);

Spot present in another anatomical region other than superior and inferior limbs;

Single lesion of small-sized tuberculoid lesion with a recent biopsy scar occupying almost the entire lesion."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-4bdbpk	Diagnostic and treatment of skin cancer lesions using Photodynamic Therapy - a less invasive technique than surgery with the application of a medication that interacts with light	Data analysis completed	Intervention	2019-04-22	<NULL>	<NULL>	2624	Diagnostic and treatment of skin cancer using Photodynamic Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-02-24	Hospital Amaral Carvalho	Instituto de Física de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4bdbpk	<NULL>	patients of both sexes; older than 18 years;  present malignant lesions of the basal cell carcinoma nodular subtype (according to the International Classification of Diseases ICD 10, code D04.9) with a maximum diameter of two (2) centimeters (initial lesions); patients with multiple lesions may also be treated, provided that each lesion fits the characteristics described in the previous item; patients with impaired neurological or judgmental capacity may be included as long as the responsible relative for their care signs the consent term.	patients allergic to any of the excipients present in the formula; infiltrative basal cell carcinoma  subtype histological micro-infiltrative, sclerodermiform, and flat-cicatricial, terebrante, as well as squamous cell carcinoma or epidermoid carcinoma and melanoma; patients with porphyria; nodular lesions  of basal cell carcinoma with more than 2 cm in diameter; patients under 18 years of age; pregnant and lactating women; women of childbearing age; patients with photosensitive diseases, for example, lupus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-5chrq5	Effect of a single session of physical exercise on blood markers in adult individuals with incomplete spinal cord injury	Data analysis completed	Intervention	2019-04-22	<NULL>	<NULL>	2625	Effect of a single session of gait training with body weight support on epigenetic parameters, brain derived neurotrophic factor levels and injury markers and peripheral blood muscle repair in adult individuals with incomplete spinal cord injury	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-16	Centro Universitário Metodista-IPA	Centro Universitário Metodista-IPA	https://ensaiosclinicos.gov.br/rg/RBR-5chrq5	<NULL>	For both groups, individuals with incomplete traumatic LM; aged between seventeen and fifty-five years old; of both genders and diagnosed for at least 6 months and at most 5 years of injury, will be included. For the trained groups, the subjects should be submitted to an intervention program (neurofunctional rehabilitation) for at least 6 months. For untrained groups, individuals should be performing only conventional physiotherapy.	As exclusion criteria, for both groups, all those with contraindications to weight support, such as individuals with hip fracture or lower limb or who present scabs, are included. Also, patients who present with unstable angina or other decompensated heart disease; chronic obstructive pulmonary disease; neurological diseases such as Parkinson&apos;s; stroke; who exhibit symptomatic drop in blood pressure when upright; who use medications with HDAC inhibitors valproic acid) and are undergoing active inflammation / infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-4rqnj3	"Patient Rehabilitation Program with Lombalgia: influence
in disability scores, heart rate variability, fear, Anxiety, Depression and Resilience"	Data analysis completed	Intervention	2018-06-05	<NULL>	<NULL>	2672	"Patient Rehabilitation Program with Lombalgia: influence
in disability scores, heart rate variability, fear, Anxiety, Depression and Resilience"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-04	Universidade Federal do Maranhão	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão - FAPEMA	https://ensaiosclinicos.gov.br/rg/RBR-4rqnj3	<NULL>	Lower back pain for at least six months; disability score assessed by the oswestry index 20%; be between 18 and 65 years old; have at least six years of schooling; be able to understand and verbalize; be available to attend the program meetings	Individuals who were submitted to lumbar spine arthrodesis; who use walking aid for locomotion; Acute and oncological diseases; Major heart disease that limits rehabilitation activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-359xvj	Application of transcutaneous electrical nerve stimulation in individuals with temporomandibular dysfunction	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2675	Transcutaneous electrical stimulation in TMD analgesia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-13	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-359xvj	<NULL>	Men and women; aged between 18 and 55 years; who presented signs and symptoms of temporomandibular myogenic dysfunction	Do not present pain in the masticatory musculature, history of systemic rheumatic disease, or were taking analgesic and / or anti-inflammatory drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-3h95h7	The effect of Transcranial direct current stimulation on Numerical abilities of children and adolescents with brain injury	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2680	Use of transcranial direct current stimulation in children and adolescents with cerebral palsy: effects on numerical cognition	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2015-06-10	Centro Paulista de Neuropsicologia	Centro Paulista de Neuropsicologia	https://ensaiosclinicos.gov.br/rg/RBR-3h95h7	<NULL>	(a) age between 8 and 14 years, (b) diagnosis of hemiplegic or diplomatic cerebral palsy, (c) they are enrolled in regular schools and have no school delay for more than two years, (d) complaint of difficulties in learning math.	use of medication with action on the central nervous system; diagnosed psychiatric, genetic, metabolic or degenerative disease; epilepsy; sleep disorders; congenital malformations; IQ of less than 75	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-5zcggj	3D glasses may improve adherence to treatment in Glaucoma patients that use only one eyedrop. A clinical study.	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2681	3D virtual reality may enhance adherence in glaucoma patients using monotherapy - a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-10	HCloe Clinica Oftalmológica Especializada	HCloe Clinica Oftalmológica Especializada	https://ensaiosclinicos.gov.br/rg/RBR-5zcggj	<NULL>	We included glaucoma patients with age equal to or above 18; who were already being treated at our clinics; with the minimal visual acuity 20/40 according to the Snellen table	The exclusion criteria included an age of fewer than 18-years-old; the demand for surgery during the three-month evaluation period; corneal diseases that interfered with the accurate measurement of intraocular pressure (IOP);  retinal diseases that impeded the quality of an optical tomography coherence exam (OCT) and computer perimetry.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-4c47pt	Development of a liver&apos;s drug at Hospital das Clínicas	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	2695	Development of ursodeoxycholic acid 300 mg at Hospital das Clinicas of FMUSP	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-19	Hospital das Clínicas	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4c47pt	<NULL>	Diagnosis of Primary Biliary Cholangitis; Male or female; 18 years old; and atients on regular treatment for at least 6 months with commercial drug (Ursacol)	"Any other co-existing liver diseases; pregnancy; 
-withdrawal of consent; patients not adherent to treatment with reference drug and known intolerance to the study drugs"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-7k6xvc	Impact of weekly speech therapy in the rehabilitation of stroke patients with swallowing disorders	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2703	Impact of weekly speech therapy in the rehabilitation of stroke patients with Dysphagia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-12-14	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-7k6xvc	<NULL>	"medical diagnosis of stroke;
dysphagia after stroke;
use of enteral probe for feeding; 
40 years or more."	"neoplasias;
patients who lived in places where it would be impossible to access through the means of transportation used in the home care programs of the two hospitals."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-2fqwqy	Sociodemofraphic characteristics and pain assessment through  the Mcgill questionnaire in women with Primary Dysmenorrhoea submitted to Auriculotherapy	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2705	Auriculotherapy in the Treatment of Primary Dismenorriation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Associação Teresinense de Ensino SC LTDA	Associação Teresinense de Ensino SC LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2fqwqy	<NULL>	The study included women with sedentary ages ranging from 18 to 25 years old with PD diagnosis; according to the nondigorous PD guideline; with a history of a regular menstrual cycle (cycle of 27 to 32 days); non-smoker; with availability of time to perform Auriculotherapy applications; not to perform other physiotherapeutic treatments; and those who accepted to participate in the research by signing the Informed Consent Term (TCLE).	Women with other physical illnesses causing pain; history of pregnancy and / or severe heart; gynecological or autoimmune diseases; in use of any psychotropic drug or hormonal contraception in the last six months; as well as, subjects submitted prior to acupuncture treatment; volunteers with needle phobias and participants who did not respond fully to the sociodemographic questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-5sv6r8	Influence of isolated strength training and dual task strength training for the elderly: morphofunctional, cognitive adaptations and blood concentrations of brain-derived neurotrophic factor	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2706	Dual-task Strength training: morphofunctional, cognitive and hormonal adaptations in healthy elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-19	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5sv6r8	<NULL>	Age equal or superior to 60 years; not part of a structured, systematic and organized program of physical exercises; have a score equal to or higher than 20 points in the mini mental state examination (MMSE); walk independently; make available for the participation of a four-month exercise program	Physical and / or cognitive impairment to prevent physical exercise; history of heart disease (e.i. acute myocardial infarction), neurological (e.g. Alzheimer&apos;s disease), psychiatric (e.i. schizophrenia),cerebrovascular (e.i. cerebrovascular accident) or metabolic (e.i., diabetes mellitus I); not comply with a minimum of 90% of the total frequency of activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-3vnwnq	Effects of the application of educational technology for guidance of parturient companions	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2707	Effects of educational technology for guiding female followers in labor in a reference maternity hospital in Fortaleza-Ceará	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Maternidade Escola Assis Chateaubriand	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-3vnwnq	<NULL>	healthy volunteers; both genders; older than 18 years; chosen by the pregnant women to participate in delivery as companions.	volunteers with cognitive impairment that prevented them from understanding the orientations that were being addressed; be accompanied by pregnant women with fetal death; companions of women who presented obstetric complications that contraindicated the use of non-pharmacological methods of pain relief.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-6n573b	Effect of Infrared LEDs compared to Respiratory Therapy Maneuvers in the Treatment of Community Pneumonia	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2714	Comparison of Infrared LED with Respiratory Physiotherapy Maneuvers in the Treatment of Community-Acquired Pneumonia	<NULL>	2, non-randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-05-01	Centro Universitário de Itajubá	PÂMELA CAMILA PEREIRA	https://ensaiosclinicos.gov.br/rg/RBR-6n573b	<NULL>	Participants aged 55-85 years; with a clinical diagnosis of community-acquired pneumonia (Streptococcus pneumoniae); undergoing conventional respiratory physiotherapy treatment; on oxygen therapy up to 1 L/minO2 and on antibiotic therapy (azalides, cephalosporins, fluoroquinolones); both sexes	Patients diagnosed with fungal and viral pneumonia; with hospital-acquired pneumonia (those hospitalized for more than 2 days in the previous 90 days); institutionalized; overweight (Body Mass Index – BMI: above 29.9 kg/m2); who do not sign the Informed Consent Form; who do not belong to the stated age range; who have neoplasms and a history of photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:08
RBR-5yv2xr	Use of corticoid associated with local anesthetic in anesthesia technique for video-assisted shoulder surgery	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	2718	Prolongation of sensory block with the combination of Dexamethasone and Levobupivacaine in the brachial plexus block for shoulder arthroscopy	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2017-01-01	Financiamento próprio.	Financiamento próprio.	https://ensaiosclinicos.gov.br/rg/RBR-5yv2xr	<NULL>	Adult patients; age between 18 and 65 years; physical status 1 and 2 of the American Society of Anesthesiology (ASA P1 and P2); body mass index (BMI) &lt;30 kg / m2; both sexes; submitted to shoulder arthroscopy for treatment of rotator cuff rupture.	Puncture site skin infection; coagulopathy; brachial plexus neuropathy; systemic use of corticosteroids; routine use of opioids; diabetes; severe lung disease; psychiatric illness; and intolerance to one or more study medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-89hr2h	Electromyographic evaluation of respiratory muscles in children born Prematurely during Exercise Test	Data analysis completed	Observational	2019-06-07	<NULL>	<NULL>	2725	Electromyographic evaluation of respiratory muscles in children born Prematurely during Exercise Test	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-05-10	universidade federal de são paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-89hr2h	<NULL>	"Children between 6 and 9 years old or friends / relatives of children born prematurely. The preterm group: birth weight less than 1500 grams and gestational age less than 37 weeks and with no gait / run difficulties.
Control group: children between 6 and 9 years old, relatives or friends of the children included in the study."	Respiratory disorders such as wheezing and/or respiratory distress in the 2 weeks prior; acute pulmonary disease diagnosed by a physician;neurological and/or cognitive impairment that prevented understanding of the test; gait dysfunction; fractures and lower limb surgery in the previous 6months; hemodynamic alterations at rest such as tachycardia and/or hypertension; and hospitalization in the previous 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-2bqy9p	randomized clinical trial on actinic keratoses of the face	Data analysis completed	Intervention	2019-06-07	<NULL>	<NULL>	2727	randomized clinical trial of microneedling followed by 5-Fluorouracil 5% versus use of 5-Fluorouracil 5% or 0.5% isolated in actinic keratoses of the face	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-03-31	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2bqy9p	<NULL>	patients with actinic keratosis on face  with minimum age of eighteen years no history preliminary melanoma	renal transplanted patients in use of immunosuppressors history of previous melanoma with health change	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-33s6x5	Effect of a mouthwash containing Cinnamomum zeylanicum Blume (Cinnamon) for treatment of oral candidiasis	Data analysis completed	Intervention	2019-06-07	<NULL>	<NULL>	2731	"Clinical evaluation of a mouthwash based on Cinnamomum zeylanicum Blume (Cinnamon) on
Candida species in patients with denture stomatitis"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-33s6x5	<NULL>	Individuals aged 40 to 70 years with oral candidiasis and who wore removable dentures.	Individuals who had undergone topical and/or systemic antimicrobial treatment or were sensitive to C. zeylanicum EO or nystatin were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-7pz64y	Use of Laser in the healing of teeth Removal of patients submitted to Dental extraction after Radiotherapy in the head and neck region	Data analysis completed	Intervention	2019-06-11	<NULL>	<NULL>	2751	Use of Photobiomodulation in the Alveolar Repair of patients submitted to Exodontia after Radiotherapy in the head and neck region a double blind and randomized clinical study	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-10-01	Thyago Morais Vicente da Silva	Hospital de Câncer de Pernambuco - HCP	https://ensaiosclinicos.gov.br/rg/RBR-7pz64y	<NULL>	Were over 18 years of age; had presence of teeth requiring simple extraction; had a history of radiotherapy in the head and neck with a minimum of 60Gy in the maxilla and/or mandible; over 3 months since the conclusion of radiotherapy in the head and neck.	Patients allergic to penicillin, individuals with systemic compromise that would contraindicate the surgical procedure, in addition to patients undergoing palliative treatment, without the indication of surgical intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-2q2f7h	Effectiveness of a nursing intervention for the reduction of preoperative anxiety in patients scheduled for knee surgery: Randomized, preventive controlled clinical trial	Data analysis completed	Intervention	2019-06-13	<NULL>	<NULL>	2758	Effectiveness of a nursing intervention for the reduction of preoperative anxiety in patients scheduled for knee surgery: Randomized, preventive controlled clinical tria	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Universidad Nacional de Colombia	Clinica de Especialistas	https://ensaiosclinicos.gov.br/rg/RBR-2q2f7h	<NULL>	"Comprised patients admitted to the 
preoperative evaluation, during the period from January to April 30 2018. Inclusion 
criteria were: persons between 50 to 75 years, patients scheduled for replacement less than 2 
months after the procedure knee"	"Exclusion criteria were: people with intellectual cognitive 
impairment, programmed to a different arthroplasty or knee replacement and denial of the 
patient to participate in research surgical procedure people."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-5jwzw4	Use of mobile goniometry application	Data analysis completed	Intervention	2019-06-15	<NULL>	<NULL>	2764	Validation and reliability of a goniometry application for mobile device (ANDROID): GONIOAPP	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-03	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-5jwzw4	<NULL>	Students of the physiotherapy course of the Lutheran University of Brazil Campus Torres; age above 18 years; have signed the Term of Free and Informed Consent (TCLE)	Missed on one of the evaluation days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-4w8tdb	Effectiveness of Dentifrice with Fluoride Controlled-release System for Remineralization of White spot: Randomized clinical study	Data analysis completed	Intervention	2019-06-17	<NULL>	<NULL>	2765	Effectiveness of Dentifrice with Fluoride Controlled-release System for Remineralization of White spot: Randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal da Paraíba	Savoy	https://ensaiosclinicos.gov.br/rg/RBR-4w8tdb	<NULL>	Age of 10 to 16 years that accept to participate of the research (agreement of agreement) and with consent of the parents or responsible ones (TCLE); has at least one lesion of active white spot on the vestibular face.	orthodontic appliance users; have extensive caries lesions or tooth sensitivity; children who do not allow the clinical examination. Also excluded are children and adolescents who are not residents of the metropolitan area of João Pessoa or exposed to drinking water from wells or sources other than the city&apos;s supply network	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-9p4kst	How physical training is able to improve chest pain in patients without coronary disease	Data analysis completed	Intervention	2019-06-17	<NULL>	<NULL>	2768	Study of the mechanisms involved in the beneficial effects of aerobic physical training in patients with coronary microvascular dysfunction	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2012-04-02	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-9p4kst	<NULL>	"Patients with a diagnosis of coronary microvascular angina.
Patients of both genders, aged between 18 and 80 years."	"Precordial pain whose clinical features suggest non-ischemic origin;
Presence of obstructive lesions in coronary arteries that irrigate the ischemic area;
Physical limitation to aerobic exercise on treadmill;
Contraindication to the practice of moderate intensity aerobic physical activity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-5c8f9m	Movement and sensibility, financial condition and welfare state of person after suffering from stroke	Data analysis completed	Intervention	2019-06-18	<NULL>	<NULL>	2770	Sensory-motor profile, socio-economic level and quality of life after Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-05	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5c8f9m	<NULL>	Individuals should authorize the procedures by signing the Free and Informed Consent Form, in addition to presenting the sequelae of stroke for at least six months.	The individuals with cognitive deficit and motor impairment that prevented the understanding and accomplishment of the evaluation were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-3yg34r	Study of the use of drugs used for dyslipidemia by the patients of the Pharmaceutical Care Service of the 4th Regional of Irati-PR and evaluation of service satisfaction	Data analysis completed	Intervention	2019-06-27	<NULL>	<NULL>	2793	Study of pharmacotherapeutic from the Clinical Protocol and Therapeutic Guidelines (PCDT / MS) of dyslipidemia applied to the Pharmaceutical Care Service of the 4th Regional of Irati-PR and evaluation of service satisfaction: A pharmacoepidemiological approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-3yg34r	<NULL>	Patients diagnosed with dyslipidemia; using drugs from the Specialized Component of Pharmacy Assistance for dyslipidemia; over 18 years old; polymedicated; with more than 3 comorbidities.	Pregnant women; under 18; alcoholics; psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-5xgjwm	Effect of Maternal Supplementation with Vitamin A, offered at different intervals, on vitamin A concentrations in breast milk and on the nutritional status of the mother and baby	Data analysis completed	Intervention	2019-07-02	<NULL>	<NULL>	2794	Impact of Maternal Supplementation with Double Megadose of Vitamin A administered at different intervals on the composition of the mother&apos;s milk and nutritional status of the mother-child binomial	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2011-07-01	Universidade Federal de Pernambuco	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5xgjwm	<NULL>	Age between 18 and 40 years. Low obstetric risk	Diabetes. Hypertension. Neoplasms. Diseases of the gastrointestinal tract. Liver diseases. Cardiovascular diseases. Infectious diseases. Mental disorder. Preterm birth, Twin pregnancy. Congenital malformations. Cerebral palsy. Supplementation with vitamin A during gestation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-5prgcn	The use of a Therapeutic Tool to reduce symptoms of Depression	Data analysis completed	Intervention	2018-05-07	<NULL>	<NULL>	2799	The use of Biofeedback in reducing depressive symptoms in users of Psychiatric Outpatient Clinic and Psychosocial Care Center: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-06	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-5prgcn	<NULL>	18 years of age or older; being accompanied in the service due to depression; being on medication for depression; meet the criteria of the International Neuropsychiatric Interview (MINI) for depression; present scores from 20 to 63 of the Beck Depression Inventory (BDI)	Persons in acute stage of hallucination and dissociation; in dependence on psychoactive substances, except nicotine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-5btyvr	Effects of Aquatic Physiotherapy on the function, quality of life and risk of falls in the elderly in Curitiba	Data analysis completed	Intervention	2019-07-05	<NULL>	<NULL>	2804	Effects of Aquatic Physiotherapy on functional capacity, quality of life and risk of falls in the elderly in Curitiba	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-25	Faculdade Dom Bosco	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-5btyvr	<NULL>	Elderly aged 60 years or over; being on the waiting list for hydrotherapy at the Pardinho Ombudsman&apos;s Physical Activity Center	Elderly people with urinary or fecal incontinence will be excluded; open wounds; infectious cutaneous diseases; infectious diseases; uncontrolled blood pressure; recent postoperative period; cognitive alteration that prevents completion of the questionnaire; participation in another program of physical activity or physiotherapeutic rehabilitation; elderly with severe neurological and cardiac problems; or any other clinical problem that would contraindicate the performance of the tests and exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-9jxvpp	The physical exercise in the treatment of chronic non-specific back pain: a comparative study between bodybuilding and exercises without machines or dumbbells.	Data analysis completed	Intervention	2019-07-08	<NULL>	<NULL>	2808	The physical exercise in the treatment of non-specific chronic low back pain: a comparative study between bodybuilding and functional training.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9jxvpp	<NULL>	The study sample will be composed of patients attended at the outpatient clinic diagnosed with chronic non-specific back pain of both sexes aged 18-65 years.	Patients who have undergone surgery in the spine; who are severely obese; pregnant; or who present with disabling pain to practice exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-2qycn4	Pilates Method and Postural Balance in Adolescent Soccer Players	Data analysis completed	Intervention	2019-07-10	<NULL>	<NULL>	2816	Evaluation of postural control and functional capacity in children practicing regular exercise.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-06	Unopar - Universidade Norte do Paraná	Unopar - Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2qycn4	<NULL>	"Adolescents soccer players aged between 13 and 15 years old, training 3 times a week, for at least 1 (one) year;

Parental Permission signed by Parents or Legal Guardians and Adolescent participant."	"Previous history of surgery in the musculoskeletal system;

Presence of musculoskeletal, respiratory, neurological and / or cardiovascular diseases;

Use of medication continuously or within 30 days prior to the evaluation day;

Have received or are receiving any type of treatment for postural changes or balance problems;

Have received or be receiving any type of treatment using the Pilates method."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-3f3vkj	Occurrence of Mental Diseases between Diabetics in tratament with Insulin	Data analysis completed	Observational	2019-07-15	<NULL>	<NULL>	2827	Occurrence of Psychiatric Disorders between Diabetics of type II in treatment with Insulin: A case-control study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-02-03	Universidade do extremo sul catarinense	Universidade do extremo sul catarinense	https://ensaiosclinicos.gov.br/rg/RBR-3f3vkj	<NULL>	"individuals aged 60 to 79 years;
Systemic Arterial Hypertension (SAH);
Acute Myocardial Infarction (AMI);
Encephalic  Vascular Accident (EVA)."	Under 60 and over 79; without some related pathology in the inclusion criteria; to have bipolarity and schizophrenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-69dnfz	Applying ICDAS  to decrease of the disallowance rate in Dental Care Delivery Systems	Data analysis completed	Intervention	2019-07-19	<NULL>	<NULL>	2828	Application and effects of ICDAS in Dental Audit	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2014-10-01	Dentistry School of Piracicaba. State University of Campinas (FOP-UNICAMP)	Dentistry School of Piracicaba. State University of Campinas (FOP-UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-69dnfz	<NULL>	Dentists/auditors who worked in the accredited network for more than 1 year; who had professional experience of over 10 years; who freely accepted to participate in this study; dentists who performed large quantities of dental caries treatments in the dental care delivery system, before and during the study.	Dentists/auditors who were invited but who did not agree to participate in the study; dentists who did not perform caries treatments after receiving the training; dentists who participated in the training but did not reach an acceptable level of concordance regarding ICDAS (weighted Kappa Index equal to or greater than 0.75).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-8fvwxq	Impact of preventive child oral health programs in Primary Health Care	Data analysis completed	Intervention	2015-03-30	<NULL>	<NULL>	2836	Impact of preventive child oral health programs in Primary Health Care	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-8fvwxq	<NULL>	Children born in 2013/2014 in the attended territory of 12 Basic Health Units of the Community Health Service of Grupo Hospitalar Conceição, located in the city of Porto Alegre, Rio Grande do Sul, Brazil and who are correctly registered and under follow-up medical attention in the Children Program; Mothers/fathers/responsible adults: the person responsible for the child’s oral health care and who follows all dental appointments in the health unit will be considered.	Children with special needs or syndromes; children who left the attended territory of Community Health Service of Grupo Hospitalar Conceição health units for more than 6 consecutive months; Mothers/fathers/responsible adults without cognitive conditions to answer the study’s surveys.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-7jy2f7	methods of caries removal - A multicenter study	Data analysis completed	Intervention	2016-10-24	<NULL>	<NULL>	2837	partial versus complete removal of decayed tissue - a multicenter controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Federal do Rio Grande do Sul	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-7jy2f7	<NULL>	Teeth with occlusal contact with the antagonist and proximal contact in cases of occlusal proximal restorations at baseline; active deep carious lesions in dentin limited occlusal and occlusal proximal surface of deciduous molars; lesion in the dentine deep to 1 mm separating the injury of the pulp and the pulp to the dentin amelo junction divided by 2 the lesion must be on the inner half of dentin; absence of clinical diagnosis of pulp exposure; absence of fistula; absence of swelling and mobility not compatible with root resorption; absence of clinical signs and symptoms of irreversible pulpitis; absence of radiolucency in the furcation or periapical region or spacing of the periodontal ligament; lack of internal or external root resorption pathological; 4 to 8 years old; both sexes; good general health; children whose parents read and signed the consent form;	patients suffering from bruxism; dental erosion; fluorosis and severe hypoplasia; patients with motor problems;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-3ddg2k	Effects of treatment of painful shoulder muscle nodules on shoulder pain, mobility, and muscle function in individuals with shoulder pain	Data analysis completed	Intervention	2018-07-10	<NULL>	<NULL>	2839	Effects of ischemic compression therapy at myofascial trigger points on pain, mobility, and muscle function of the shoulder complex in individuals with shoulder pain	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3ddg2k	<NULL>	Presence of at least one active or latent PGM, on the symptomatic side, in one of the following muscles: upper trapezius, lower trapezius, supraspinatus, infraspinatus, minor pectoris and middle deltoid.The subjects should have a history of unilateral shoulder pain, lasting more than one week, located in the proximal anterolateral region of the shoulder, or in the C5 or C6 dermatome region; Least three of the special tests for SIS diagnosis considered positive: Neer test; Hawkins&apos; test; Jobe&apos;s test; Painful arch test; External rotation resistance test; Gerber test and Speed biceps test.	Signs and symptoms of bilateral SIS;Primary adhesive capsulitis; Reproduction of shoulder pain which radiates to the entire upper limb; Numbness or tingling in the upper limb or any other symptom in the upper limb during foraminal compression test; History of symptom onset due to glenohumeral displacement or subluxation; Joint deformation in the glenoid or humeral head; Or fracture of the clavicle, scapula or humerus;History of surgical stabilization or repair of the rotator cuff;Groove test or positive seizure test;Signs of complete rupture of the rotator cuff, as evidenced by the positive fall test; Systemic disease involving joints such as rheumatoid arthritis and systemic lupus erythematosus and fibromyalgia, which involves myofascial tissue;Neurological pathologies; Use of analgesics and muscle relaxants 72 hours before the evaluation;Use of corticoid injection 3 months prior to evaluation;Body mass index (BMI)&gt; 28kg /m2;Symptoms of depression, with score 13 in the Beck Depression Inventory;Be there for a period of 1 month without participating in any program of physiotherapeutic treatment, stretching, strengthening or specific resistance exercises for the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-8d755f	Respiratory muscle training in patients with respiratory diseases	Data analysis completed	Intervention	2019-07-24	<NULL>	<NULL>	2844	Respiratory muscle training in COPD patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Estadual Paulista Rio Claro	Universidade Estadual Paulista Rio Claro	https://ensaiosclinicos.gov.br/rg/RBR-8d755f	<NULL>	Diagnosis of COPD according to the Global Initiative for Chronic Obstructive Lung Disease- GOLD; 18 to 90 years; clinically stable for at least four weeks; no smokers for at least six months,both genres.	Do not perform all the tests proposed; not to attend at least 85% of the training protocol; to present exacerbation of the disease during the period of application of the protocol; present need for hospitalization for any reason; hospital admission history in the last four weeks prior to the start of training; clinical instability; diagnosis of associated disease that prevents the performance of any of the proposed activities; participation in any pulmonary rehabilitation program; not to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-4r26fz	Application of the knowledge, skill and attitude questionnaire regarding the Monitors used in the Intensive Care Unit	Data analysis completed	Intervention	2019-07-24	<NULL>	<NULL>	2848	"Application of cha inventory (knowledge, skill and attitude) and intervention,
the use of multiparametric monitors in an intensive care unit"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Triângulo Mineiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-4r26fz	<NULL>	The entire nursing team (nurses and technicians) was included in the survey, which currently comprises the staff of the chosen services. Thus the inclusion of all the team was intentional, considering the particular characteristics of the study group. For this purpose, they agreed to participate in the study, by signing the Term of Clarification for the participants, as well as the Free Consent Form after Clarification for Participants prepared according to Resolution 466/12 of the National Health Council (BRAZIL, 2012).	Those who were on maternity leave and leave were excluded from the study. As the forecast for the data collection was three months in some situations it was not possible to wait for the return of employees who were away for health or maternity leave. Those professionals who were reassigned from sectors, dismissed or did not participate in all stages of the research (regarding pre- and post-intervention) were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-5974nc	Effect of electrical stimulation on menstrual cramps	Data analysis completed	Intervention	2019-07-31	<NULL>	<NULL>	2856	Therapeutic effect of high and low frequency transcutaneous nervous electric stimulation in pelvic pain caused by primary dismenorrhea syndrome: a comparative study	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-06-01	SOBEU - Associação Barramansense de Ensino	SOBEU - Associação Barramansense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-5974nc	<NULL>	Age between 18 and 35 years; pelvic pain caused by dysmenorrhea; being between the first and third day of the menstrual cycle, degrees between 1 and 10 on the Visual Analogue Pain Scale (EVA)	Age inferior to 18 and superior to 35 years; use of analgesics and other therapies for pelvic pain; gynecological conditions; undiagnosed abdominal pain; heart pacemaker; cardiac complications; degree 0 on the Visual Analogue Pain Scale (VAS).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-7gn68p	Profile of protein expression of root canal infections	Data analysis completed	Intervention	2019-08-07	<NULL>	<NULL>	2861	Proteomic profile of endodontic infections	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista	Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7gn68p	<NULL>	A total of 6 patients were included in this study, 2 with normal pulp (orthodontic indication of extraction), 2 with pulpitis and 2 with chronic apical periodontitis. Therefore, the patients should present the pulp conditions mentioned and for the endodontic treatment of the teeth with inflammation and pulp necrosis, they should be able to be isolated with a rubber dam.	Patients without systemic disease. Patients whose teeth cannot be restored.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-529dpg	Effects of early mobilization on normal and cesarean birth	Data analysis completed	Intervention	2019-08-07	<NULL>	<NULL>	2865	Physiotherapy assistance in the immediate puerperium: a comparative study between normal birth and cesarean	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-529dpg	<NULL>	The study included women with 8 hours normal postpartum and 14 hours postpartum cesarean section, primiparous and multiparous, with medical authorization to perform physiotherapy, without any complications, such as hemorrhages and who accepted to be part of the study after the signature of the free and informed consent term	Were excluded from the study postpartum women less than 8 hours normal postpartum and 14 hours post-partum cesarean section, complications during delivery and postpartum, with anesthesia headache, bleeding, exacerbated pain in another body part, carriers of morbidities such as diabetes and hypertension who underwent curettage and tinnitus without medical authorization to receive physical therapy and who did not accept to be part of the study after reading the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-9mzjcb	Effect of Reiki  (integrative and complementary practice of laying hand) on anxiety  of nursing academics	Data analysis completed	Intervention	2019-08-13	<NULL>	<NULL>	2869	Effect of Reiki on anxiety level of nursing academics	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-19	Curso de Enfermagem do Instituto de Biotecnologia da Universidade Federal de Goiás - Regional Catalão	Universidade Federal de Goiás - Regional Catalão	https://ensaiosclinicos.gov.br/rg/RBR-9mzjcb	<NULL>	Academics over 18, of both sexes; not participating in other extension projects that involve integrative and complementary practices; which are compatible with the days of application of the reiki technique.	infectious and communicable diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-4897pw	Reduction of postoperative pain in knee ligament surgery: morphine versus femoral block	Data analysis completed	Intervention	2019-08-14	<NULL>	<NULL>	2872	Postoperative Analgesia: Intrathecal Morphine versus Femoral Block	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2013-12-03	Hospital Universitário Cajuru	Hospital Universitário Cajuru	https://ensaiosclinicos.gov.br/rg/RBR-4897pw	<NULL>	Patients submitted to elective surgery using the technique of anatomical reconstruction of the ACL with flexor tendons (semitendinous and gracilis); age between 18 and 65 years; classified as ASA I or II; score of at least 15 on the Glasgow Coma Scale; with the capacity to correctly answer the questionnaire applied by the researcher; who signed the informed consent term.	"Patients who did not meet the inclusion criteria; 
presence of other painful complaints that could confound the postoperative evaluation; sensory or motor neurological deficit of the lower limbs; infection at the puncture site; previous coagulopathies and / or INR 
less or equal 1.5; with another contraindication to the proposed technique; history of allergic reaction to some of the drugs used in the studies; patients with diabetes mellitus due to the increased probability of previous neuropathy due to the disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-9sg585	The effect of laser and fluoride application in the treatment of dentin hypersensitivity	Data analysis completed	Intervention	2019-08-14	<NULL>	<NULL>	2874	Efficacy of laser and desensitizing agents in the treatment ofDentin Hypersensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-13	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9sg585	<NULL>	The sample will be composed of individuals diagnosed with dentin hypersensitivity greater than or equal to 2 in the verbal classification scale (RSV) after evaporative and tactile stimulation in at least one healthy tooth with gingival recession. Individuals above the age of 18 years, who agree to participate in the study will be included by signing the informed consent form (TCLE)	Individuals submitted to periodontal treatment in the last 30 days, individuals submitted to treatment for dentinal hypersensitivity in the last 30 days (treatment with fluoride, scraping and laser), pregnant and lactating; individuals with a carious, cavitary or restorative tooth .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-4xxz7j	Self-select intensity exercise selected for the elderly: implications of affect in community classrooms	Data analysis completed	Observational	2019-08-16	<NULL>	<NULL>	2878	Influence of functional capacity and health parameters on responses psychophysiology of the elderly	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-30	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4xxz7j	<NULL>	Over 60 years old; at least 6 months of participation in regular physical exercises at the community center; medical authorization for physical exercise; do not have comorbidities that interfere with walking	Failure to comply with the research procedures; want for your participation in the study; feel uncomfortable in the study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-59552p	Comparison between two medications in pain control of dental infection: a clinical research in patients	Data analysis completed	Intervention	2019-08-19	<NULL>	<NULL>	2881	Comparison between isolated and associated with Codeine Paracetamol in pain con-trol of Acute Apical Abscess: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-59552p	<NULL>	Patients were included in this research according to the following criteria: individuals 18 to 80 years old; diagnosis of acute apical abscess with pulpar necrosis origin; reporting mod-erate to severe pain at the first appointment (equal or superior to 40mm on VAS).	"They will be relieved to report being allergic to drugs not present, patients with a history of liver disease and infants.
Patients with chronic and / or anti-inflammatory opiates were also excluded, those who were or are users of substances such as crack, oxy, cocaine, marijuana and solvents. In addition, patients with cognitive (and therefore according to scales) as well as patients with cognitive impairment (and therefore from afar)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-7g7rq3	Analysis of cardiac and respiratory components after walking exercise in patients who suffered a stroke	Data analysis completed	Intervention	2019-08-20	<NULL>	<NULL>	2882	Cardiac Variability in Aerobic and Resistant Training of patients with Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-15	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7g7rq3	<NULL>	Patients between the ages of 40 and 65 years; verification of the stroke by image examination and medical report; injury time over one year; acceptance in participating in the intervention	Patients who could not walk or clinical conditions for walking; other neurological diseases; did not have medical clearance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-46rtbv	Comparison between training of two virtual games in the thigh muscle and functional performance of the lower limb	Data analysis completed	Intervention	2019-08-27	<NULL>	<NULL>	2901	Comparison between the effects of plyometric training and virtual training on electromyographic activity, kinematics, and functional performance of the trunk and lower limb	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-46rtbv	<NULL>	women aged 18 to 30 years; healthy	Women who had serious health problems; current or previous injuries in the lower limbs; signs of inflammation; pain and joint instability in the knee	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-3q6j7x	Acute effect of a Futsal Match on mood status, memory and attention in individuals with Chemical Dependence	Data analysis completed	Intervention	2019-08-27	<NULL>	<NULL>	2902	Emotional states, Physical Exercise and cognitive functions in people with Alcohol and Drug use Disorder in the CAPS ad	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-26	Centro Universitário Católico Salesiano Auxilium	Centro Universitário Católico Salesiano Auxilium	https://ensaiosclinicos.gov.br/rg/RBR-3q6j7x	<NULL>	The inclusion criteria were: male gender; aged between 18 and 45 years; diagnosis of drug dependence, guided by the International Classification of Diseases (ICD-10) regardless of the time of treatment and dependence; no health restrictions and limitations identified by the PAR-Q questionnaire; and no impairment in mental state identified by the mini-mental state examination.	The exclusion criteria were: to present physical or mental limitations that prevented participation in the futsal match	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-4vrz2m	Evaluation of DNA damage in anesthesiologists	Data analysis completed	Observational	2015-03-25	<NULL>	<NULL>	2906	Damage assessment in the genetic material in anesthesiologists	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-05-07	Departamento de Anestesiologia	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4vrz2m	<NULL>	Anesthesiologists to compose the exposed group medical and clinical settings to compose the control group; healthy volunteers; both genders; non-smoking; age between 23 to 75 years.	Malignants diseases; infectious diseases; inflammatory diseases; alcohol consumption; use of tobacco; illicit drug use; use of medications; use of vitamin supplementation; radiation exposure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-954xsg	Monitoring of caries lesions among primary teeth after block with resin infiltrant	Data analysis completed	Intervention	2016-04-01	<NULL>	<NULL>	2907	Progression of early proximal caries lesions on primary molars after Sealing with Resin Infiltration: longitudinal follow up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-07	Faculdade de odontologia da Universidade Federal do Rio Grande do Sul	Jonas de Almeida Rodrigues	https://ensaiosclinicos.gov.br/rg/RBR-954xsg	<NULL>	Patients with at least 2 not clinically evident carious lesions that only involve proximal surface, in primary molars that presents radiolucence to the outer third of dentin.	Children who refuse to carry out longitudinal follow-up radiographs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-6gf6dx	Study of occupational exposure in anesthesiologists	Data analysis completed	Observational	2017-09-12	<NULL>	<NULL>	2909	"Evaluation of redox status, inflammatory response, telomeres and gene expression in 
anesthesiologists"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6gf6dx	<NULL>	Anesthesiologists to compose the exposed group medical and clinical settings to compose the control group; healthy volunteers; both genders; non-smoking; age between 23 to 75 years.	Malignants diseases; infectious diseases; inflammatory diseases; alcohol consumption; use of tobacco; illicit drug use; use of medications; use of vitamin supplementation; radiation exposure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-4qdx3v	Different materials for the technique of Atraumatic Restoration in deciduous teeth of children, a clinical investigation with 3 years of follow-up	Data analysis completed	Intervention	2018-07-13	<NULL>	<NULL>	2911	Randomized double blind clinical trial using different materials in deciduous teeth of children by the ART technique: two years of follow-up	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-07	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4qdx3v	<NULL>	Healthy Volunteer Children; both genders; duly enrolled in municipal schools; with an acceptable oral hygiene level; with a minimum of 4 years and a maximum of 9 years	Children who are missing on scheduled restorations day; those responsible do not sign the Free and Informed Consent Form; children who do not accept by bad behavior the oral examination or the realization of the restorations; teeth with very deep carious lesions; fistulated teeth; with such spontaneous pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-4gmvpg	Translation of the Expected Consequences of Hearing Aid Ownership questionnaire into Portuguese	Data analysis completed	Observational	2019-08-28	<NULL>	<NULL>	2913	Cultural adaptation of the Expected Consequences of Hearing aid Ownership (ECHO) questionnaire for Brazilian Portuguese	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-27	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4gmvpg	<NULL>	Signature of Consent Form and Free Clarified; diagnosis of hearing loss; good general health, so that they can be presented to the clinic for care; the same or more than 18 years; comprehension capacity to respond to the questionnaire.	Refusal to reply to the questionnaire; did not have comprehension capacity to answer the questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-8bh5k7	Immediate effects of Acupuncture on strength and muscle pain	Data analysis completed	Intervention	2019-08-29	<NULL>	<NULL>	2916	Effects of the Acupuncture application on the delayed onset muscle soreness (DOMS) and in the muscle contraction capacity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-25	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8bh5k7	<NULL>	"Participants should have at least two years of resistance training experience, in which the biceps curl exercise was part of their training routines.  Participants were considered as physically active, i.e., exercised from two to three times per week using light to moderate intensities,  before the commencement of the experiment.
Participants above 18 years or older"	Participants with upper limb articular and muscular conditions that could affect muscle strength, e.g., tendinitis, bursitis, recent fractures, etc., hypertension or hypotension and or under the effect of drugs such as corticoids, psychotropic, anti-inflammatory, and analgesic, were excluded from the study.  In addition, participants with an excessive fear of needles were not included. Aged over 40 years-old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-6369bw	Treatment before and after shoulder muscle injury surgery	Data analysis completed	Intervention	2019-08-30	<NULL>	<NULL>	2918	Rehabilitation pre-and post-operative of Rotator Cuff injury	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-04	Faculdade de Ciências Médicas e da Saude de Juiz de Fora - Suprema	Faculdade de Ciências Médicas e da Saude de Juiz de Fora - Suprema	https://ensaiosclinicos.gov.br/rg/RBR-6369bw	<NULL>	Individuals a history of shoulder pain after trauma and diagnosed with rotator cuff injury by an orthopedic shoulder surgeon through clinical examination and confirmed by magnetic resonance imaging	Fractures or pre-existing shoulder conditions such as adhesive capsulitis; joint instability; and labral lesion were excluded; as were those who were absent at any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-59hy2k	Metabolic and inflammatory effects of decreasing preoperative fasting time in preschool children undergoing inguinal hernia repair	Data analysis completed	Intervention	2019-08-30	<NULL>	<NULL>	2919	Metabolic and inflammatory results of reducing preoperative fasting time in preschool children undergoing inguinal hernia repair	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-26	Santa Casa de Misericórdia de Cuiabá	Santa Casa de Misericórdia de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-59hy2k	<NULL>	The enrolled patients were children aged from 2 to 6 years; who were to be treated at the hospital Santa Casa of Misericórdia;  presented an anesthetic risk classified as ASA I or II (healthy patient or small morbidity); and were to be operated for  inguinal elective herniorrhaphy (small and moderate inguinal hernias).	Where excluded patients with other concomitant surgical diagnoses detected during hospitalization; as well as patients with giant inguinal hernias; those whose surgeries were cancelled due to respiratory symptoms; patients whose parents declined to participate in the study; with failure during collection of blood samples; who did not correctly followed the perioperative protocol delineated by the research where also excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-3n9wxw	The effect of Platelet Rich- plasma on facial aging	Data analysis completed	Intervention	2019-09-04	<NULL>	<NULL>	2927	The use of Platelet Rich Plasma in the treatment of skin aging	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-18	Centro de Hematologia e Hemoterapia - HEMOCENTRO	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3n9wxw	<NULL>	Healthy volunteers; women; non-smokers; age between 40 and 65 years; Glogau grade II or III photoaging; Fitzpatrick phototype I-IV	Volunteers smoking; history of alcohol or drug abuse; pregnant or in the puerperium; facial aesthetics with absorbent material (hyaluronic acid), laser use in the last year, use of retinoic acid, application of botox or filling and surgical procedures; patients with a history of photosensitivity and of keloid or hypertrophic scar; patients with lesions of infected or inflamed skin on the face in the last year; underlying diseases such as uncontrolled hypertension, liver disease, renal, haematological, inflammatory, rheumatologic, diabetes; patients who have or have had dysplasias;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-9pkxn2	Active Life: discovering healthy paths	Data analysis completed	Intervention	2019-09-05	<NULL>	<NULL>	2929	Active Life: discovering healthy paths	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-16	Universidade Federal de Santa Catarina	Illinois University of Urban-Champaign	https://ensaiosclinicos.gov.br/rg/RBR-9pkxn2	<NULL>	"Study participants were men and women aged 60 or older;
no severe physical and/or mental health impairments;
not participate in physical activity programs in the past six months."	"Heart attack and/or stroke in the past six months;
cancer diagnosis in the past six months;
other severe medical conditions in the past six months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-44bjjf	Does Ketamine in anesthesia produces superior, inferior or similar analgesia compared to Morphine in uterus removal surgery	Data analysis completed	Intervention	2019-09-09	<NULL>	<NULL>	2930	Does intrathecal Ketamine produces superior, inferior or similar analgesia compared to Morphine in Abdominal Hysterectomy surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-08	Hospital São José do Avaí	Santa Casa de Belo Horizonte - Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-44bjjf	<NULL>	The study enrolled women; over 18 years old; scheduled for elective abdominal hysterectomy at Hospital São José do Avaí; ASA I-III patients.	patients unlikely to be fully cooperative during the study; allergy to dipyrone/ketoprofen; non-indication for spinal anesthesia; cognitive impairment; severe renal impairment; lack of consent to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-96j9xn	Effect of exercise on body fat, blood glucose, blood pressure and body damage in type 2 diabetic	Data analysis completed	Intervention	2019-09-11	<NULL>	<NULL>	2934	Effect of a training program on body composition, glycemic profile, blood pressure, inflammatory process and oxidative stress in type 2 diabetics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-30	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-96j9xn	<NULL>	Medical diagnosis of type 2 diabetes at least 12 mouths; 40 to 65 years; 25 to 35 kg/m² BMI; be sedentary or insufficiently active in IPAQ-vc (MATSUDO et al., 2001); regular drug hypoglycemic treatment; do not use insulin and anti-inflammatory drugs.	Changes in drug hypoglycemic treatment; begin chronic use of anti-inflammatory drugs; injuries in muscles; bones and/or tendon; significant changes in nutritional behavior or physical activity; as well as miss 25% of training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-8mq8bs	Buried or exposed pins in wrist fractures - What causes more infection? A randomized clinical trial	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	2939	Buried or exposed K-wires in distal radius fractures - What causes more infection? A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-09	Universidade Federal do Pará	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-8mq8bs	<NULL>	Patients of both genders; equal or over 18 years-old; with distal third radius fracture treated with closed reduction and percutaneous fixation with 2 Kirschner wires of 1.5mm of caliber.	Patients under 18  years-old; open fractures; Immunossuppressed patients;  necessity of more than two Kirschner wires to fix the fracture; open reduction; associated fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-37v5s3	Efficacy of fluoride gel on incipient enamel lesions: a randomized clinical trial	Data analysis completed	Intervention	2018-05-14	<NULL>	<NULL>	2940	Efficacy of 1.23% acidulated phosphate fluoride gel on incipient enamel lesions: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-37v5s3	<NULL>	"Have at least one incipient enamel lesion in vestibular, palatal or occlusal surface in deciduous or permanent dentition; Have
access to fluoridated water and use fluoridated toothpaste."	Systemic alterations that may interfere in the development of caries; Have received topical fluoride in the last six months; Cognitive impairment who can not adhere to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-2mg3xw	Effects of olive oil treatments for facial dark spots	Data analysis completed	Intervention	2019-09-16	<NULL>	<NULL>	2946	Clinical efficacy of oral and topical treatments based on olive oil extract titrated in hydroxytyrosol to melasma control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-30	Faculdade de Ciências Farmacêuticas de Riberão Preto - USP	Faculdade de Ciências Farmacêuticas de Riberão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-2mg3xw	<NULL>	30 to 50 years old; phototype III and IV (Fitzpatrick, 1998); facial hyperpigmentations patterns.	hyperpigmentations not diagnosed as melasma in the malar region; pregnancy or breastfeeding; individuals with a history of adverse reactions with the use of cosmetic products; individuals in the use of drugs capable of producing an abnormal skin response; cosmetic and dermo-cosmetic whitening treatments, superficial chemical peels and laser for less than 3 months; use of oral antioxidant supplementation for less than 3 months; localized or generalized dermatological diseases; excess hair on face.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-4vsv5c	Depression Acceptance and Commitment Therapy in the Elderly	Data analysis completed	Intervention	2019-09-17	<NULL>	<NULL>	2954	Cognitive Behavioral Therapy and Geriatric Depression: A Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4vsv5c	<NULL>	60 years or older; reside in the research city; not being in psychotherapy, achieving the expected score on the EDG-15 (instrument for geriatric depression) and the MMSE (cognitive deficits).	Not reside in the research city; being in psychotherapy; present evidence of dementia (MMSE) or absence of depressive symptoms (EDG-15) in the respective instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-2gw2f5	Clay poultice combined with therapeutic exercises for pain reduction in patients with osteoarthritis	Data analysis completed	Intervention	2019-09-18	<NULL>	<NULL>	2962	Effect of geotherapy combined with kinesiotherapy and resistance exercise in knee osteoarthritis: single-blinded randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-03	Centro Universitário Adventista de São Paulo	Centro Universitário Adventista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gw2f5	<NULL>	diagnosis of osteoarthritis; older than 20 years of age	presence of any other chronic disease; total or partial prosthesis in one or both knees or hips; presence of heart disease; uncontrolled hypertension; rheumatoid arthritis; fibromyalgia; neurological diseases affecting mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-2pb8gq	Development of a Brain-controlled Gait Apparatus to restore the walking of people with Spinal Cord Injury	Data analysis completed	Observational	2019-09-18	<NULL>	<NULL>	2968	Walk Again Project: development of a Robotic Orthosis Controlled by Biological Signals to restore the ambulation in patients with Spinal Cord Injury	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-04	Associação Alberto Santos Dumont para Apoio à Pesquisa	Associação Alberto Santos Dumont para Apoio à Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-2pb8gq	<NULL>	18 years old or over; Lesion T4 to L2; SCI AIS A, B, C or D; Presence of chronic, traumatic, six months to 3 years of SCI.	"Has seizures; Has contractures in the legs (shortening of a muscle or tendon); Do not have time for project activities; Participates in other research; Cardiopulmonary instability; Abuse of alcohol or drugs, psychiatric illness, or history of head trauma with loss of consciousness within 3 months of recruitment; Use of drugs known to exert negative effects on motor recovery; Cognitive deficit; Pregnancy or of childbearing potential and not using adequate contraception; Presence of ferromagnetic material in the skull, except in the mouth; 
Presence of cardiac and/or neural pacemakers;
Untreated depression; Spasticity at the lower end of a MAS score equal or higher than 2; Uncontrolled diabetes; Severe osteoporosis; Decubitus ulcer that may interfere with the belt placement or any other necessary feature of the LT BWST-assisted robot and the exoskeleton."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-8dymr8	Impact of a nurse-oriented educational strategy on the reduction of hospital readmissions in patients with heart failure	Data analysis completed	Intervention	2019-09-18	<NULL>	<NULL>	2969	Impact of a nurse-oriented educational strategy on the reduction of hospital readmissions in patients with heart failure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8dymr8	<NULL>	Patients of both sexes. Aged 18 years or more. With the medical diagnosis of heart failure with systolic dysfunction ejection fraction greater than or equal to 49% by the echocardiogram. Admitted for clinical decompensation related to changes of vital parameters and laboratory tests and/or image.	With cognitive deficit assessed by mine mental State examination. Without the possibility of telephone contact. Functional Class 4 by NYHA. With visual, auditory deficit and impaired mobility. And those who are participating in another research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:01
RBR-4v4298	Respiratory Exercises with children with Cleft lip and/or palate	Data analysis completed	Intervention	2019-09-19	<NULL>	<NULL>	2973	Muscular expiratory training in children with cleft lip and/or cleft palate: Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-12	Universidade Federal de Ciências da Saúde de Porto Alegre	Hospital da Criança Santo Antônio	https://ensaiosclinicos.gov.br/rg/RBR-4v4298	<NULL>	Subjects with Cleft Lip and/or Palate; aged between three and 12 years; corrected by surgery of cheiloplasty and palatoplasty	Patients with cleft lip and palate who had any other associated malformation; those with intellectual disability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-76xrqj	Effect of psychotherapy on Heart Failure	Data analysis completed	Intervention	2019-09-20	<NULL>	<NULL>	2975	Mental health in Heart Failure: prevalent diagnoses and psychological intervention from short-term psychoanalytic listening	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-11	Faculdade de Medicina da Universidade Federal Fluminense	Clínica de Insuficiência Cardíaca Coração Valente	https://ensaiosclinicos.gov.br/rg/RBR-76xrqj	<NULL>	Patients over 18 years of age and of any NYHA functional class	Psychotherapy patients; with psychotropic use during intervention; severe neurological sequel; severe psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-4w6yh4	Stress and metabolic markers in response to acute exercise	Data analysis completed	Intervention	2017-07-31	<NULL>	<NULL>	2977	Stress and metabolic markers in response to acute exercise in women between 25 and 40 years of age	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde	Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4w6yh4	<NULL>	Apparently healthy women; Sedentary; Do not be a smoker; Without hypertension, diabetes, hyper or hypothyroidism; No use of antinconceptional or any hypoglycemic.	Participant with hypertension; diabetes; Use of medications that influence the cardiovascular or endocrine system; With musculoskeletal limitation for walking or running. Also, do not agree to participate in all research procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-4995cr	Influence of verbal command on upper limb motor improvement of subjects after stroke	Data analysis completed	Observational	2019-09-20	<NULL>	<NULL>	2979	Different focus of attention on improvement of upper limb motor performance post-stroke	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi (Facisa)	https://ensaiosclinicos.gov.br/rg/RBR-4995cr	<NULL>	"Greater than 18 years old;
Clinical diagnosis of stroke (ischemic or hemorrhagic);
Just one stroke;
Realize flexor and extensor synergies by the Fugl Meyer scale;"	"Sensory impairment;
Cognitive impairment;
Aphasia;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-55g6cm	Evaluation of the effectiveness of toothpastes in reducing gum bleeding	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2983	Evaluation of the effectiveness of toothpastes in reducing gum bleeding	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-55g6cm	<NULL>	Good general health; ability to read, understand and sign the Informed Consent Form; willingness to comply with study procedures and sampling schedules; at least 20 natural permanent teeth without crown (excluding third molars); mean gingival index (Löe &amp; Silness 1967) greater than or equal to 1.5; at least 6 teeth with a minimum of one bleed site on marginal probing	Have a history of allergy to previously used oral hygiene products or their ingredients; have a history of alcohol or drug abuse; have infectious diseases (e.g hepatitis or AIDS); have a medical condition that could compromise patient safety or the quality of study results; need antibiotics before dental treatment; use anti-inflammatory, immunosuppressive, antimicrobial, anticoagulant or antibiotic drugs within 30 days prior to the start of the study; continuous use of medications known to affect gum tissues; have important oral conditions (including but not limited to oral or soft tissue hard tumor (s), gingival hyperplasia, moderate to severe periodontitis including two or more periodontal pockets greater than 5 mm with bleeding on probing),presence of orthodontic bands or removable partial dentures; presence of five or more carious lesions requiring immediate restorative treatment; being pregnant or breastfeeding; referring to the use of tobacco products; having any pre-existing medical condition prohibiting the subject from eating or drinking for periods of up to 2 hours, have participated in a clinical study involving oral care products in the previous month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-9hc9dz	Agents used for dental sensitivity during whitening: a clinical study	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2984	Evaluation of In-Office Desensitizing Agents used during 35% Hydrogen Peroxide Bleaching: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	São Leopoldo Mandic - SL Mandic	São Leopoldo Mandic - SL Mandic	https://ensaiosclinicos.gov.br/rg/RBR-9hc9dz	<NULL>	Presence of at least 20 permanent teeth (including all anterior teeth); be between 18 and 30 years of age; absence of restorations in the six upper anterior teeth; absence of active caries or periodontal disease; commitment not to use tobacco during the study period.	History of any systemic disease that may interfere with the results; have undergone any previous bleaching treatment; patients using analgesics and / or anti-inflammatories; pregnant or breastfeeding patients; Patients smokers; teeth with tetracycline stains; patients with orthodontic appliances or removable prostheses; patients with gingival retraction or with cracks in the enamel; patient with previous dental sensitivity; patient with poor oral hygiene and presence of active caries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-2dhtzh	Adherence to self-care in leprosy in the light of Everett Rogers Theory	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2987	Adherence to self-care in leprosy in the light of Everett Rogers Theory	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Programa de Pós-Graduação em Enfermagem da Universidade Federal da Paraíba	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-2dhtzh	<NULL>	Patients in treatment with MDT who met the inclusion criteria were considered eligible: age of majority, confirmation of leprosy diagnosis, multibacillary operational classification, with treatment between the second and ninth supervised dose (avoiding termination of the treatment during the intervention process).	The new cases, considering that these situations individuals receive guidance at the time of consultation, and therefore have a prior lack of a pathological condition; those unable to perform activities of self-care due to visual impairment, mental disorder and / or severe physical limitations; and patients with disabilities of cognitive understanding that prevent participation in educational intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-3zfkgt	Bleaching efficacy and tooth sensitivity of active application of a in-office bleaching agent	Data analysis completed	Intervention	2019-09-23	<NULL>	<NULL>	2988	Clinical evaluation of 20% hydrogen peroxide in-office bleaching gel effectiveness with and without sonic activation in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3zfkgt	<NULL>	Being aged 18 years old or older, having good general and oral health, having anterior maxillary teeth free of cavity or restorations on buccal surface, having maxillary central incisors shaded on C2 ou darker assessed by Vita Classic (Vita Zahnfabrik, Bad Säckingen, Alemanha).	Participants with orthodontic devices, pregnant or lactating, severe internal tooth discolouration (tetracycline, fluorosis or pulpal death), bruxism or other pre-existent pathologies that may cause spontaneous tooth pain (gingival recession or dentin exposure), non-carious cervical lesions, anterior restorations or who were using antioxidant or antiinflammatory drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-89489x	Possible Effects of the Use of Silicon Oxide Pads in Cases of Cervical Spine Pain in Academics of Dentistry	Data analysis completed	Intervention	2019-09-24	<NULL>	<NULL>	2994	Possible Effects of Stiperterapia in Cases of Pain in the Cervical Spine in Academics of Dentistry	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-18	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-89489x	<NULL>	"Academic students enrolled in Unisul&apos;s Dentistry course and attending the 5th to 10th phase that corresponds to the period of clinical practice and present a complaint of cervicalgia;
Age from 19 years."	"To present injury due to trauma or disc herniation in the cervical region;
Have a history of allergy or tape intolerance;
Present any skin lesion in the area corresponding to the cervical / scapular region;
Continued or frequent use of analgesic or myorelaxant medications;
Being in physical therapy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-9mfcyv	Estudo clínico da efetividade de sabonetes líquidos desinfetantes no controle da placa bacteriana presente em dentaduras	Data analysis completed	Intervention	2019-09-26	<NULL>	<NULL>	2998	"Estudo clínico da efetividade de sabonetes líquidos desinfetantes no controle do
biofilme presente em próteses totais"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Faculdade de Odontologia de Araraquara	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9mfcyv	<NULL>	Be between 45 and 80 years old; To be a user of superior removable total dentures;  Do not use any chemical cleaning agent on your dentures during the period of the research and at least 3 months; Present normal salivary flow with mean of 0.7 mL / minute and at least 0.5 mL / minute; Show good general health for at least 6 months; The total dentures should be able to be used (with stability, without fractures and without the presence of repacking material); The prosthesis should not be more than 5 years old.	Whose prosthesis presents problems in the adaptation, need of relining, repairs and or fractures; With systemic infectious diseases (hepatitis, AIDS) or local; That they present oral Candidosis at any level according to the modified Newton classification; With serious and limiting diseases; In the treatment of malignancies or who use immunosuppressive, systemic antibiotic and / or antifungal medicines in the three months prior to the study; With special needs, physical disabilities, or with committed manual dexterity; Smokers; Diabetics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-9p66gk	Nutritional follow-up in radiotherapy patients	Data analysis completed	Intervention	2019-09-26	<NULL>	<NULL>	3001	Nutritional follow-up in patients with head, neck and esophageal Cancer undergoing radiotherapy treatment (chemo)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-11	Sheila Cristina Pootz	Universidade de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9p66gk	<NULL>	Diagnosis of head and neck or esophageal cancer; individual does not have another catabolic disease such as HIV or cirrhosis; both genders; age between 18 and 100 years.	Age under 18 years; carrier of another catabolic disease such as cirrhosis or HIV; tumor located in different region of head and neck or esophagus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-65q4hg	Effect of vitamin C supplementation on children with Osteogenesis Imperfecta	Data analysis completed	Intervention	2019-09-27	<NULL>	<NULL>	3006	Evaluation of musculoskeletal pain and collagen production in patients with vitamin C supplemented osteogenesis imperfecta: pilot study of a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-14	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-65q4hg	<NULL>	Patients with OI (types I, III and IV) and without other associated diseases. Age range from zero to 18 years. Patients who underwent intravenous disodium pamidronate treatment cycles at the HIJG every 2, 3, 4, or 6 months between January and December 2018. Patients who had conditions for oral medication administration. Patients who do not use continuous analgesics, continuous anti-inflammatory drugs or antidepressants for pain control or other medical indication.	PParticipants who did not attend the hospital for disodium pamidronate administration. Participants who presented temporary or permanent suspension of disodium pamidronate administration during the data collection period. Participants who did not have blood samples collected during the first or second data collection. Participants who did not return for the second data collection. Participants who used continuous analgesics, continuous anti-inflammatory drugs and antidepressants for pain control or other medical indication after the first data collection. Participants reporting inadequate vitamin C supplementation between data collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-62sxcr	The Bad Ragaz Method On The Functionality Of Diabetic	Data analysis completed	Intervention	2019-09-17	<NULL>	<NULL>	3025	Effect Of The Bad Ragaz Method On The Functionality Of Diabetic Elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	UNIVERSIDADE FEDERAL DO PIAUÍ	UNIVERSIDADE FEDERAL DO PIAUÍ	https://ensaiosclinicos.gov.br/rg/RBR-62sxcr	<NULL>	"The research will include the elderly in the clinical sector physiotherapy school in the
between 60 and 80 years of age; regardless of gender; those who agreed to participate in the
research through the signing of the informed consent form (TCLE)."	"Will be excluded from the research the gerontans who present psychiatric disorder;
injuries; metabolic decompensation; labyrinthitis; otitis; low cognition; second
advocated by the Ministry of Health, through the Mimi Mental State Examination (BRASIL,
2006) or those who withdraw their consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-85fsrb	Folic acid excess: effects on vitamins B2 and B6 concentrations, tryptophan and immune system	Data analysis completed	Intervention	2019-10-03	<NULL>	<NULL>	3026	Folic acid excess: effects on vitamins B2 and B6 metabolism, tryptophan catabolism and immune response	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-85fsrb	<NULL>	Healthy subjects; both sexes; aged between 18 and 45 years	Individuals under 18 years, chronic alcoholics; patients with acute or chronic diseases; pregnant women; users of immunossupressive medications, vitamins or vitamin supplements; blood donors in the last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-3r3mqw	Effects of a containing ora-pro-nobis product on the gut and anthropometric data in adults	Data analysis completed	Intervention	2019-10-03	<NULL>	<NULL>	3028	Development of containing Ora-Pro-Nobis (Pereskia aculeata Mill.) Product and its influence on intestinal microbiota, antioxidant capacity, anti-inflammatory, biochemical and anthropometric parameters in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3r3mqw	<NULL>	Women, aged between 20 and 60 years. Fat percentage above 25%. Not having participated in weight loss program in the last six months; Be healthy.	"Have a diagnosis of autoimmune, endocrine, cardiac, cerebrovascular, renal, hepatic, gout, gastrointestinal, inflammatory and / or infectious diseases;
have made use of dietary supplements, laxatives and antibiotics in the last six months;
have undergone surgery in the last six months;
have made regular use of alcohol, cigarettes and other drugs in the last year;
be vegetarian;
being on herbal remedies or preparations;
exhibit allergic reactions to product components;
be pregnant or nursing;
have ingested probiotic in the last year."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-2vj7sw	Analysis of the evolution of patients with Chronic Cervicalgia as a function of the Treatment of Choice.	Data analysis completed	Intervention	2019-01-02	<NULL>	<NULL>	3035	Analysis of the clinical evolution of the Patient with Non-specific Chronic Neck Pain as a Choice of Treatment Choice. A randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-2vj7sw	<NULL>	Current neck pain. Neck pain continued for at least the last twelve weeks.	Irradiated neck pain. Neck pain associated with dizziness. Osteoporosis. Psychological disorders. Vertebral fractures Tumors Metabolic diseases. Previous neck surgery Red Flags (Night pain, severe muscle spasm, loss of involuntary weight, symptom mismatch). Physiotherapeutic treatment continued in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-5t95n5	Comparison between different types of exercises to strengthen in patients with osteoarthritis of the knee	Data analysis completed	Intervention	2013-07-15	<NULL>	<NULL>	3044	Effect of strength training in different kinetic chains in pain, quality of life, the pattern of muscle recruitment during ascent and descent of stairs and joint position sense in patients with osteoarthritis of the knee	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-07-20	Universidade Federal de Uberlândia	Fundação de Apoio Universitário	https://ensaiosclinicos.gov.br/rg/RBR-5t95n5	<NULL>	Individuals of both sexes between 50 and 80 years, which presented diagnosis of osteoarthritis (OA) according to the criteria of the American College of Rheumatology, accompanied by radiological evidence, affecting one or more compartments of the knee, at the mild or moderate, with knee pain for six months or more and bilateral involvement.	Participants will have other musculoskeletal changes, chronic inflammatory diseases such as autoimmune diseases (rheumatoid arthritis, lupus, etc), diabetes mellitus, and neuromuscular disorders such as Parkinson&apos;s disease, vertigo and other conditions that may affect the sensory and control of movement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-83ckh3	Comparison of drugs for anxiety relief before heart surgery	Data analysis completed	Intervention	2012-02-13	<NULL>	<NULL>	3047	Randomized blind prospective study: a comparison of midazolan, morphine or clonidine as premedication for cardiac surgery	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-08-01	Instituto de Cardiologia do Rio Grande do Sul	Ari Tadeu Lírio dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-83ckh3	<NULL>	Patients undergoing cardiac surgery with cardiopulmonary bypass; age of 18-65 years.	Non-elective surgery; weigh less than 50 or more than 100 kg; history of psychiatric disorder; ASA physics status of class IV; patients with a mental impairment, knowledge about allergy to studied drugs;  patients with congenital cardiac disease and the patients that don&apos;t give informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-6d7twh	Prospective, randomized study of chronic pain in the inguinal region and recurrence after inguinal hernia surgery by videolaparoscopy by intra-abdominal technique comparing mesh fixation with staples, glue or just its placement	Data analysis completed	Intervention	2019-10-09	<NULL>	<NULL>	3057	Prospective , randomize study of inguinodinia and recurrence after videolaparoscopic inguinal hernioplasty by transabdominal technique comparing mesh fixation with tackers , glue or no fixation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-04	Hospital de Transplantes Euryclides de Jesus Zerbini	Hospital de Transplantes Euryclides de Jesus Zerbini	https://ensaiosclinicos.gov.br/rg/RBR-6d7twh	<NULL>	patients of both genders; age between 18 and 75 years; body mass index (BMI) less than 35 kg / m2; unilateral inguinal hernia patients classified as Nyhus Type II or III; American Society of Anesthesiology Physical State Classification (American Society of Anesthesiology - ASA) I, II and III.	Patients with bilateral inguinal hernia; recurrence , encarcerated; strangled; ; Users of chronic painkillers; Corticosteroid users; patients with fibromyalgia; patients on antidepressants; anxiolytics, carbamazepine, diphenylhydantoin, gabapentin, and pregabalin; patients with previous surgery on the ínguino-crural region; right iliac fossa; hypogastrus; Patients with benign prostatic hyperplasia, not released after urological evaluation; Patients undergoing prostatic surgery for cancer or not; American Society of Anesthesiology (ASA) IV and V Physical State Classification and Users of Illicit Drugs and Alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-38kgxy	Effect of Neuroscience Education in Pain combined to Pilates in Catastrophization for Elderly with non-specific Chronic Low Back Pain: A Randomized Controlled Trial	Data analysis completed	Intervention	2019-01-03	<NULL>	<NULL>	3071	Pain Neuroscience Eucation for the older people with chronic low back pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-11	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-38kgxy	<NULL>	"Participants will be recruited from the municipality of São Carlos through advertisements in the community and media.
Individuals aged 60 years or older with non- specific chronic low back pain who score the minimum score according to schooling in the Mini Mental State Examination MMSE and do not present depressive symptoms in the Geriatric Depression Scale GDS-15.For the classification of chronic pain was used the criteria of the International Association for the Study of Pain IASP, which recommends that, for research, the chronicity of pain is defined as lasting more than six months (IASP, 2015)."	All older people that have undergone physical therapy for pain management within 6 months prior to the intervention, or undergone surgical treatment for CLBP were excluded, involvement in regular sports activities that have the same physical benefits as Pilates, such as improved muscle strength and stretching. Those with diagnosis of central sensitization syndromes (such as fibromyalgia), cancer and active inflammatory diseases, or with pain associated to previous spine or lower limbs fracture, and those that already regularly performed physical activities with therapeutic aims of stretching and strengthening similar to Pilates will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-2pxsw7	Physiotherapeutic performance in the treatment of Mastalgia in women of the Center for Care of Women and Children (CASMUC)	Data analysis completed	Intervention	2019-10-15	<NULL>	<NULL>	3088	Physiotherapeutic performance in the treatment of Mastalgia in women of the Center for Care of Women and Children (CASMUC)	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-2pxsw7	<NULL>	Patient diagnosed with Mastalgia not related to breast cancer, referred to CASMUC&apos;s medical outpatient clinic, above 18 years of age, and who accepted to participate in the study after reading and signing the Informed Consent Term (TCLE).	Women with uncontrolled systemic arterial hypertension and cognitive dysfunction were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-5s4yqh	Study of the application of protocol in the prevention of peri-intraventricular haemorragia in preterm newborns	Data analysis completed	Intervention	2019-10-16	<NULL>	<NULL>	3094	Study of the Application of a bundle in the prevention of peri-intraventricular haemorragia in preterm newborns	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Estadual do Ceará	Maternidade Escola Assis Chateubriant	https://ensaiosclinicos.gov.br/rg/RBR-5s4yqh	<NULL>	To be premature with gestational age less than or equal to thirty-four (34) weeks at birth and / or Birth weight less than or equal to 1,500 (one thousand, five hundred) grams.	Newborns with congenital malformations, genetic syndromes and those with congenital infections of the TORCHS group (syphilis, rubella, herpes, toxoplasmosis and cytomegalovirus).  Newborns who died before the first ultrasonographic examination or were transferred to another institution due to overcrowding of the Neonatal Unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-2c3kyz	Vacuum dressing for suture healing in pilonidal cyst surgery	Data analysis completed	Intervention	2019-10-16	<NULL>	<NULL>	3097	Use of negative wound pressure device in surgical treatment of Pilonidal Cyst in closed technique.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-19	universidade de santo amaro	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-2c3kyz	<NULL>	Patients with primary or recurrent Pilonidal Cyst	Patients using anti-coagulants or decompensated systemic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-567trz	Evaluation of the effect of a 6% potassium nitrate gel on tooth sensitivity during and after office whitening in adult patients	Data analysis completed	Intervention	2019-10-16	<NULL>	<NULL>	3102	Effectiveness of a 6% potassium nitrate gel on sensitivity during and after office bleaching in adults	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-567trz	<NULL>	Patients of both sexes were included in the present study; aged between 18 and 40 years; who had at least six upper anterior teeth free of caries and restorations on the buccal surface; central or canine incisor with A2 or darker coloration; satisfactory oral hygiene; absence of periodontal disease.	The individuals excluded from the study were users of fixed orthodontic appliances; pregnant women; lactating women; severe intrinsic stains on teeth (stains due to tetracycline, fluorosis and pulped teeth); who were consuming any anti-inflammatory and antioxidant drugs; using desensitizing toothpaste; participants with a previous history of tooth sensitivity or any associated pathology (bruxism, gingival recession, noncarious lesion with dentin exposure).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-9jgsb5	Using Behavioral Nutrition techniques for health promotion	Data analysis completed	Intervention	2019-10-17	<NULL>	<NULL>	3105	Using Health and Wellness Coaching techniques to change parameters of health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Escola de Educação Física e Esportes da Universidade de São Paulo	Escola de Educação Física e Esportes da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9jgsb5	<NULL>	Women; overweight; premenopause	Men; women who are normal weight or obese; menopausal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7pckqt	Postoperative pain measurement after knee anterior cruciate ligament reconstruction surgery with analgesic medications within the joint	Data analysis completed	Intervention	2019-10-21	<NULL>	<NULL>	3113	Evaluation of postoperative pain in patients undergoing arthroscopic knee anterior cruciate ligament reconstruction with intraarticular analgesic solutions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Fundacao Hospital Adriano Jorge	Fundacao Hospital Adriano Jorge	https://ensaiosclinicos.gov.br/rg/RBR-7pckqt	<NULL>	The following inclusion criteria were adopted: diagnosis of chronic knee instability; older than 18 years; classification of physical status according to the American Society of Anesthesiologists (ASA) I and II scale; no local and systemic inflammatory diseases; isolated injuries of the anterior cruciate ligament (ACL only), with no history of fractures or previous knee surgery; use as a graft the medial flexor tendons; operated by the principal researcher and his team	Exclusion criteria were: skeletally immature patients; chondral lesions larger than 2 cm2; associated surgical procedures such as osteotomies, and other ligaments; patients without clinical conditions, hypertensive, with coagulopathies, pregnant; chronic use of anticoagulants; analgesic use up to 24 h before the surgical procedure; patients who refused to sign the consent form; patients not operated at the institution: the anesthesiologist&apos;s refusal to follow the project protocol and patients who declared themselves indigenous; older than 65 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7y35v6	Effects of the combination of strengthening exercises and blood flow block on hand strength gain	Data analysis completed	Intervention	2019-10-21	<NULL>	<NULL>	3114	Comparison of different strengthening protocols associated with blood flow restriction to increase handgrip strength	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Universidade Federal de Santa Catarina- UFSC	Universidade Federal de Santa Catarina- UFSC	https://ensaiosclinicos.gov.br/rg/RBR-7y35v6	<NULL>	Female volunteers; aged between 18 and 25 years old; students; and able to perform the proposed activities were included.	Volunteers with a history of forearm injury that compromised muscle integrity; or who had a history of fractures in the wrist and fingers, upper limb pain; hypertensive patients; heart disease; cognitive impairment; manual workers; and practitioners were excluded of physical activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-4kzgt4	Effectiveness of bleaching with carbamide peroxide using sonic ativation and genetic toxicity	Data analysis completed	Intervention	2019-10-22	<NULL>	<NULL>	3120	Effectiveness of bleaching with 37% carbamide peroxide with and without sonic activation and genotoxic effect: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-4kzgt4	<NULL>	Patients included in this clinical trial were men and women over 18 years; who were in good general and oral health; with six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade C2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Pregnant or lactating patients were excluded; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); orthodontic appliance users; gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-595x7r	The effect of virtual reality on the static and dynamic balance of stroke patients.	Data analysis completed	Intervention	2019-10-24	<NULL>	<NULL>	3125	The Effect Of Virtual Reality on the Static and Dynamic Balance on Patients with Stroke.	<NULL>	4, single-arm-study, double-blind	4	<NULL>	<NULL>	<NULL>	2019-07-01	Financiamento próprio	Financiamento próprio	https://ensaiosclinicos.gov.br/rg/RBR-595x7r	<NULL>	Individual with stroke; chronic; static and dynamic balance deficit.	Individuals with acute stroke; individuals without static and dynamic balance deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7ms43m	Comparative evaluation of the mandible head / mandibular fossa relationship in patients with symptomatology or not in two positions by computed tomography	Data analysis completed	Intervention	2019-10-24	<NULL>	<NULL>	3129	Comparative evaluation of the mandible head / mandibular fossa relationship in asymptomatic and symptomatic adult individuals in the centric and maximal intercuspal clearance through cone beam computed tomography	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7ms43m	<NULL>	To participate in the study, besides belonging to the pre-established age groups for each group of this study, the individuals of the sample should present all dental elements (the presence of third molars being optional) and the absence of previous report of unilateral or bilateral articular ankylosis. or significant trauma in the TMJ region.	The criteria used to exclude any individuals from participation in this research were: previous orthodontic treatment, signs of advanced periodontal disease, subjects undergoing previous occlusal adjustment, history of facial trauma, systemic diseases with anatomical degeneration of the mandible or mandibular fossa, trismus. and teeth with active caries process that can cause odontogenic pain. These criteria were determined with the objective of eliminating factors that could mask the initial conditions, introduce etiological and / or iatrogenic factors or prevent the implementation of the methodology present in this work. RDC / TMD exclusion factors such as myospasm, myositis, muscle contracture, polyarthritis, acute traumatic injuries, and temporomandibular joint infections were also used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7w8txn	Use of electrostimulation with Russian current to treat lumbar pain	Data analysis completed	Intervention	2019-10-24	<NULL>	<NULL>	3130	Analysis of the efficacy of the Russian current in the treatment of lower back pain through muscle hypertrophy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7w8txn	<NULL>	The study included sedentary female individuals; with a maximum age of 30 years; height 1.70 m; weight 75.0 kg and BMI 25 kg/m2; who presented chronic non-specific low back pain (presence of low back pain for at least 12 weeks); with a convenience sample	Individuals with surgeries in the lumbar region; skin lesions in the region to be stimulated; pregnant women; diagnosis of neurological or musculoskeletal problems (others than chronic lumbar pain); and the performance of physiotherapeutic treatment in the last three months from the day of the evaluation were discarded; besides the non-agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-7dc5mh	Physiotherapy on the risk of fall in the elderly	Data analysis completed	Intervention	2019-10-10	<NULL>	<NULL>	3132	Comparison of an aquatic physiotherapy vs conventional physiotherapy protocol in the risk of falling in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Veiga de Almeida	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-7dc5mh	<NULL>	Seniors were over the age of 60 and had reported fall incidents in the last 6 months	The exclusion criteria involved individuals who were conducting other types of treatment that could interfere in the sample, such as osteopathic manipulative techniques; conventional physiotherapeutic treatments; recent fractures; neurological diseases; fecal or urinary incontinence; arthritis in the hips or limiting knees; severe aphasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-9wk8rq	Heart rate variation in newborns exposed to melody during fetal period	Data analysis completed	Intervention	2019-10-29	<NULL>	<NULL>	3146	Heart rate in newborns exposed to melody during fetal period – controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Instituto de Medicina Integral Prof Fernando Figueira	Instituto de Medicina Integral Prof Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-9wk8rq	<NULL>	Newborns between 3 and 47 days whose mothers listened to the melody according to study methodology; Newborn with good vitality at birth; Healthy newborns; Term newborn.	Post term newborns; Preterm newborns; Newborns over 47 days old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-9yrnbg	Use of a substance to prevent and control mouth inflammation caused by radiotherapy	Data analysis completed	Intervention	2019-10-29	<NULL>	<NULL>	3148	Use of Glutamine in the prevention and control of Radio Induced Oral Mucositis	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2010-10-16	Universidade Estadual da Paraíba	Daliana Queiroga de Castro Gomes	https://ensaiosclinicos.gov.br/rg/RBR-9yrnbg	<NULL>	Patients of both sexes; regardless of ethnicity; over 18 years of age; undergoing head and neck radiotherapy with at least half of the oral mucosa area included in the radiation fields.	Patients submitted to palliative RT; those who could not open their mouths; and those who used prophylactic topical drugs or mouth rinse; and those who presented Karnofsky Performance Status&lt;70 were excluded; Interruption of use for just one day and not coming to the dental evaluation resulted in the elimination of the patient from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-6bv5hy	Comparison of the occurrence of pain after root canal treatment performed on teeth with mortified nerve with or without injury to the root of the tooth using two mechanized canal cleaning systems and two canal cleaning limits.	Data analysis completed	Intervention	2019-11-06	<NULL>	<NULL>	3169	Comparison of postoperative pain incidence in endodontic treatments performed on Pulp Necrosis teeth with or without apical lesion using two mechanized instrumentation systems and two apical instrumentation limits	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6bv5hy	<NULL>	Inclusion criteria were teeth diagnosed with asymptomatic necrosis pulp; confirmed by a negative response to pulp vitality tests with heat and cold; with or prior radiographic periapical lesion and without clinical symptoms such as pain; fistula; edema and palpation sensitivity.	We excluded from the study vital teeth, previous endodontic retreatment; teeth with open apex; teeth with periodontal problems that have periodontal probing greater than 3 mm; internal and external root resorption, dental traumatism; treatments not a single session; root canals where it was not possible to realize the patency of the apical foramen and patients allergic to some compound of the medicine ibuprofen. Also excluded were those with spontaneous pain that were included in the study; who used analgesic or anti inflammatory medication in the last ten days, who had systemic diseases and those who refused to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-2ctm5q	The effect of Pilates treatment on the physical function and immunity of patients with HTLV-related nervous system disease	Data analysis completed	Intervention	2019-11-12	<NULL>	<NULL>	3182	Impact of Pilates treatment on the clinical and immunological profile of patients with Paraparesis tropical spasticity / lymphotropic virus-associated myelopathy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-02	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-2ctm5q	<NULL>	The inclusion criteria selected individuals of both sexes; aged over 18 years old; with confirmed HTLV-1 infection and clinical diagnosis of HAM/TSP	Individuals who were under 18 years old or who had any disease that prevented treatment by Pilates exercises or presenting any disease that could influence the patients’ symptoms and unrelated to HAM/TSP; such as bone tuberculosis and the occurrence of pain caused by disc herniation or fibromyalgia; were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-4q8rgp	Effect to use occlusal bite on the progression of dental abrasion	Data analysis completed	Intervention	2019-11-18	<NULL>	<NULL>	3197	Effect of occlusal plaque on the progression of abfration lesions	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4q8rgp	<NULL>	Two visually perceptible lesions on the buccal surface of the teeth; visually perceptible and without indication of restoration; with or without TMD and / or the presence of excessive occlusal wear due to teeth clenching and / or grinding.	Non-carious cervical lesions in patients with GERD; using continuous medication that could interfere with salivary flow and promote dental erosion; those diagnosed with less than 2 abfraction lesions; very extensive lesions and teeth with gyroversion; or without antagonist and adjacent teeth and with idiopathic erosion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-2gv5c2	Effects of yoga on different health markers	Data analysis completed	Intervention	2019-11-18	<NULL>	<NULL>	3199	Effects of yoga on heart rate variability, electroencephalogram, quality of life, salivary cortisol and functional neuroimaging by magnetic resonance in healthy adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2gv5c2	<NULL>	Healthy volunteers; both genders; age between 18 and 40 years; no experience with Bhastrika Pranayama	Diagnosis of heart problems; chronic rhinitis; frequent use of aspiration bronchodilator; regular use of beta blocker or stimulant and any drug that interferes with cardiac modulation; diagnosis of neurological or psychiatric disorders; pregnancy; metallic implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-2d4vvv	Efficacy of conventional and BoNTA treatment in patients with Temporomandibular (TMD) disorder	Data analysis completed	Intervention	2019-11-19	<NULL>	<NULL>	3202	Efficacy of conventional and BoNTA treatment in patients with Temporomandibular (TMD) chronic pain	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-04	Faculdade de Odontologia de Piracicaba, Universidade estadual de Campinas	Faculdade de Odontologia de Piracicaba, Universidade estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2d4vvv	<NULL>	Female volunteers; aged 18-45 years; with muscular TMD; with pain for more than 3 months; using contraception; with all teeth; class I of Angle; having stable occlusion.	Volunteers with trauma in the face and TMJ; with bruxism; wearing dentures; on orthodontic treatment; using anti-inflammatory medication, analgesic and / or muscle relaxant; with coagulopathy; with neuralgia; with arthritis; osteoarthritis; diabetes; neurological disorders; primary headache; fibromialgy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-5xtfj9	Short-term effects of cupping as pain and movement therapy and lumbar spine	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	3229	Immediate effects of cupping on pain and range of motion of the lumbar spine	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade do Estado de Santa Catarina UDESC	Universidade do Estado de Santa Catarina UDESC	https://ensaiosclinicos.gov.br/rg/RBR-5xtfj9	<NULL>	Healthy adult volunteers; both genders; age between 18 and 60; weight within the limit of variation of 15% of that considered normal for men and women, taking into account the height and physical structure.	Volunteers with a history of alcohol or drug abuse; diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; with lesions of the central nervous system, deformities established in the spine, previous lesion in the spine, inflammatory processes in the evaluated segment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-7wv259	Fixed regimen analgesic use compared with regimen if needed for pain after gum surgery: a randomized controlled trial	Data analysis completed	Intervention	2019-11-25	<NULL>	<NULL>	3231	Pain and analgesic consumption after surgical periodontal treatment	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2016-05-04	Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-7wv259	<NULL>	Adult patients; Patients of both sexes; Patients in need of periodontal surgery with total flap to restore supracrystal insertion tissues.	Patients who use systemic analgesics; patients who use systemic antimicrobial, patients who use systemic anti-inflammatory drugs; patients who use systemic muscle relaxants; patients on systemic anxiolytic or antidepressant use; patients with previous chronic or acute pain, related or not to the oral cavity; patients who have difficulty understanding instructions (cognitive changes), impairing the application of the scales proposed by the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-8fwwj6	Short-term effects of physiotherapy techniques (myofascial release and proprioceptive neuromuscular facilitation), the movement and flexibility of posterior thigh, power and balance of amateur soccer players	Data analysis completed	Intervention	2019-08-28	<NULL>	<NULL>	3233	mmediate effects of myofascial release compared to proprioceptive neuromuscular facilitation in balance and power, range of motion, and flexibility of knee flexors of amateur soccer players	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade do Estado de Santa Catarina UDESC	Universidade do Estado de Santa Catarina UDESC	https://ensaiosclinicos.gov.br/rg/RBR-8fwwj6	<NULL>	Healthy adult volunteers; both genders; age between 18 and 35 years; weight within the variation limit of 15% of the weight considered normal for men and women, taking into account height and physical structure.	Volunteers with a history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic disorders; with lesions of the central nervous system, established deformities of lower limbs; previous hamstring muscle injury in the assessed limb; inflammatory processes established in the segment. Be performing physiotherapeutic treatment in progress; in concomitant participation in competitions and; with flexibility that exceeds the limits of the evaluation apparatus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-4gq8mk	Metabolic and Respiratory Changes in Footballers	Data analysis completed	Intervention	2019-12-02	<NULL>	<NULL>	3239	Analysis of metabolic and respiratory changes in adolescent football athletes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-30	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4gq8mk	<NULL>	Healthy and hemodynamically stable volunteers; male gender; soccer athletes; age between 14 and 15 years.	Frequency of participation less than seventy-five percent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9ypbtf	Study of HPV Vaccine adverse events and protection in patients with Juvenile Lupus and Juvenile Dermatomyositis	Data analysis completed	Intervention	2019-12-02	<NULL>	<NULL>	3242	Study of safety and immunogenicity of the vaccine against human papillomavirus (HPV) in patients with Systemic Lupus Erythematosus (JSLE) and Juvenile Dermatomyositis (JMD)	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2014-11-03	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Departamento de Pediatria e Puericultura da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9ypbtf	<NULL>	Being female; Be between 9-20 years old; Have been diagnosed with one of the following immune system disorders before the age of 17 and before their first quadrivalent vaccine against human papillomavirus: juvenile systemic lupus erythematosus or juvenile dermatomyositis; Have not received the three doses of the quadrivalent human papillomavirus vaccine	The absence of parental consent for those under 18 or consent from the patient or control; refusal of any blood collection; hx of suspected or proven cervical carcinoma; being pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-5wmn5k	Effect of stretching exercises on balance in older women	Data analysis completed	Intervention	2019-12-03	<NULL>	<NULL>	3245	Effect of flexibility training on postural control in older women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-04-12	Escola de Enfermagem Aurora de Afonso Costa- Universidade Federal Fluminense	Instituto de Educação Física -UFF	https://ensaiosclinicos.gov.br/rg/RBR-5wmn5k	<NULL>	Inclusion criteria were: elderly women aged 60 years or older, those who independently maintained their daily activities through the Baecke Modified Questionnaire, elderly women who practiced only the Prev Quedas water exercise, without participating in another exercise program. physical and those who presented medical examination authorizing the practice of physical exercises.	Exclusion criteria were: elderly women with diseases diagnosed by the doctor that compromised postural control, such as blindness or low vision, labyrinthitis, osteomioarticular diseases, Parkinson&apos;s disease and Alzheimer&apos;s disease, low cognitive ability, previous history of stroke and fall; elderly women who presented two consecutive or more absences in the proposed training, without replacement, in the same week of absence or in the following week; elderly women with a history of falling in the last 12 months; elderly women with low cognitive ability verified through the Mini Mental State Examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-2btctk	Physical Training in Postmenopausal Obese Women	Data analysis completed	Intervention	2019-12-03	<NULL>	<NULL>	3246	Physical Training in Postmenopausal Obese Women: Evaluation and Intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Faculdade de Educação Física e Fisioterapia	Faculdade de Educação Física e Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-2btctk	<NULL>	The inclusion criteria will consist of: Being between 45 and 65 years old; be obese, do not have physical problems or cardiovascular complications that prevent the performance of physical activities; have no history of any serious pathology; present a medical certificate confirming that they are able to practice physical exercise; not being a smoker; not make use of alcoholic beverages; have the menstrual cycle interrupted for another 12 months	"The criteria for not including the study will be: Make use of hormone replacement therapy; present a diagnosis of serious illnesses or
that compromise physical activity"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-9qwppm	3D Changes Associated with Surgically Assisted Rapid Palatal Expansion (SARPE): Cranial Base Overprint	Data analysis completed	Intervention	2019-12-04	<NULL>	<NULL>	3247	Surgically assisted rapid maxillary expansion (ERMAC): dental and skeletal effects assessed by cone-beam computed tomography	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade de São Paulo (USP)	Universidade de São Paulo (USP)	https://ensaiosclinicos.gov.br/rg/RBR-9qwppm	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 60 years; weight within the range of 15% of the weight considered normal for men and women, taking into account the height and physical structure, which have transverse maxillary deficiency and broad oral corridors.	Volunteers with untreated periodontal disease and / or caries lesions; systemic diseases; use of drugs that may alter bone metabolism; mechanical complications of the expanders and absence of CBCT images.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-4pysrs	University extension project for atraumatic treatment of dental caries: from assistance to sustainability, interaction between university and public health	Data analysis completed	Intervention	2019-12-04	<NULL>	<NULL>	3248	University extension project on Atraumatic Restorative Treatment: from assistance to sustainability, interaction between university and public health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-15	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4pysrs	<NULL>	"Presence of one or more caries lesions in enamel and / or
dentin in deciduous or permanent elements; age between 6 and 14 years old; both genders"	Absence of restorations or caries lesions on primary or permanent teeth; age below 6 years or above 14 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-7rwgzt	Effect of Brazil Nut consumption on mineral Selenium compounds in the continuous use of cholesterol-lowering drugs	Data analysis completed	Intervention	2017-08-07	<NULL>	<NULL>	3262	Effect of Brazil Nut (Bertholletia excelsa H.B.K.) consumption on Selenocomposites in the chronic use of Statins	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rwgzt	<NULL>	Adults subjects of both sexes; in chronic use of Statins; with muscle disorders in the case of individuals in the study group; no muscle disorders in the case of individuals in control group	Presence of serious cardiac complications or other diseases such as thyroid; hematological; congenital; autoimmune; liver disease; renal failure; cancer; associated infections; osteoporosis; postoperative; antibiotics and vitamin and mineral supplements; food allergy to oilseed; current alcoholism and smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-6nj4mk	Effects of Aquatic Physiotherapy on Epigenetic, Inflammatory and Neutotrophic factors in Parkinson&apos;s disease patients	Data analysis completed	Intervention	2019-12-10	<NULL>	<NULL>	3266	Effects of an Aquatic Physical Activity program on clinical-functional parameters, peripheral modulation of epigenetic mechanisms, inflammatory markers, and Brain Derived Neurotrophic Factor (BNDF) levels in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Centro Universitário Metodista IPA	Centro Universitário Metodista IPA	https://ensaiosclinicos.gov.br/rg/RBR-6nj4mk	<NULL>	As inclusion criteria for both control and exercise groups, subjects should present Parkinson Disease diagnosed by a neurologist (rule out parkinsonisms with other causes). In addition, they must be able to participate in the proposed physical activity program and sign the consent form. The participants need to be between 50 and 80 years old.	As exclusion criteria for both CONTROL AND EXERCISE groups, the individual should present characteristics of cognitive deficits verified through the application of the MoCa Questionnaire. Specifically for the EXERCISE group, as exclusion criteria, aspects such as the inability to participate in aquatic physiotherapy will be adopted, besides the individual presenting other diagnosed neurological and orthopedic pathologies that preclude their participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-3dgcpv	Is it safe to prescribe antibiotics at the commonly administered dose for patients with stomach reduction surgery? Study of available concentration of oral amoxicillin	Data analysis completed	Intervention	2016-12-05	<NULL>	<NULL>	3267	Is it safe to prescribe antibiotics in tablets dosage form for bariatric patients? Oral bioavailability study of amoxicillin	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-09	Núcleo de Pesquisa Clínica e Bioequivalência	Universidade Estadual de Maringá (UEM)	https://ensaiosclinicos.gov.br/rg/RBR-3dgcpv	<NULL>	"Health volunteers who have undergone bariatric surgery by the technique Roux in Y gastric band at least 3 months ago;
To be over 18 years or under 55 years old;
Has signed the Written Informed Consent Form."	"Intolerance or hypersensitivity to Amoxicillin;
Renal or hepatic faillure;
Pregnancy;
Brest-Feeding;
Alcohol or illicit drugs user;
Use of prokinetic drug (metoclopramide, erythromycin or domperidone);
Enrollment at Clinical Study in the last 3 months;
Show thrombocytopenia, anemia;
Bariatric patients by others techniques then Roux in Y gastric band;
Be under 18 or over 55 years old;
Bariatric surgery over 5 years ago;
Bariatric surgery for less than 3 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-2m93s5	Evaluation of elasticity, color change and ultrastructure of aesthetic orthodontic ligatures	Data analysis completed	Intervention	2019-12-10	<NULL>	<NULL>	3269	Aesthetic elastomeric orthodontic ligatures: Evaluation of Elastic Properties, Color Change and Ultra Surface Structure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2m93s5	<NULL>	Patients aged between 12 and 20 years; with good general and dental health; without metal tooth restorations; in orthodontic treatment and without having used mouthwashes in the last 3 months before the beginning of the experiment	Patients with some type of systemic disease; with poor dental health as the presence of dental caries, periodontal disease; or who regularly use mouthwashes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-6nv3c5	Effect of the use of a cream with leucine and lactic acid associated with electrostimulation in contouring facial	Data analysis completed	Intervention	2019-12-11	<NULL>	<NULL>	3274	Development of a cream containing leucine and lactic acid to increase facial muscle tone in adult women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-26	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6nv3c5	<NULL>	Female sex; be healthy; body mass within the range of 15% of the weight considered normal for men and women, taking into account height and physical structure; skin photo type 1 to 4 (color of skin)	Present any type of physical or mental diseases, which interfere with the use of cream in a continuous form and  in the evaluation measures, have carried out some sort of facial surgery, deficiency or absence of cutaneous sensibility, presence of scars, allergies, hematoma and/or abrasions on the face, perform any type of treatment in aesthetic centers during the study period. Women  were also excluded from the study  with occurrence of tooth pain, pregnant or lactating diseases with infectious process and/or inflammatory process in facial region, acne grade 3, use of pacemakers and metal plates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-7zhgb3	Comparison of treatment of platelet-rich plasma non-healing wounds in patients with venous abnormalities	Data analysis completed	Intervention	2019-12-17	<NULL>	<NULL>	3294	Comparison of the treatment of chronic ulcers with platelet rich plasma in patients with venous insufficiency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7zhgb3	<NULL>	Diagnosis of chronic venous insufficiency; at most 80 years old and minimum of 18 years; ulcer with diameter 10 to 40 cm²	Exclusion criteria will be: base diseases of influence on healing, patients with malignant neoplasia in the last five years, lupus, carriers of ulcers neuropathic or arterial diseases, or any other type of ulcer in the lower limbs that is not related to chronic venous insufficiency; the patients who presented 3 (three) consecutive absences or 6 (six) alternate and the non-consent to participate in the research willingly and spontaneously, Uncontrolled Systemic Arterial Hypertension (SAH), Acquired Immunodeficiency Syndrome (HIV), Anemia, Stroke or Acute Myocardial Infarction (AMI) in the last 3 months, Renal insufficiency (creatinine more than 2 mg / dl), Liver Disease (TGO more than 2x upper limit, INR more than 1.5), surgery or major trauma in the last 2 months, pregnant woman, mental retardation, inclusion in other studies in the last 30 days and relative of first or second degree of another patient in the study group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-72kd57	Effect of impact home based exercises to people with Down syndrome	Data analysis completed	Intervention	2019-12-19	<NULL>	<NULL>	3300	Effect of home based exercises to people with Down syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72kd57	<NULL>	"Have clinical and laboratory diagnosis of DS;Be in follow up in the Rehabilitation Program for people with DS of IMREA HCFMUSP Lucy Montoro;
18 to 35 years old; Preserved mobility;Normal cardiorespiratory test"	"Current heart disease;Atlantoaxial subluxation;
Severe intellectual disability;Orthopedic problems;Neurodegenerative and musculoskeletal diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-3rvfwt	Effect of combination therapy with Noninvasive Brain Stimulation and Gamotherapy in patients with Parkinson&apos;s Disease	Data analysis completed	Intervention	2019-12-26	<NULL>	<NULL>	3303	Effect analysis of combined therapy with repetitive Transcranial Magnetic Stimulation (rTMS) and gametherapy on motor and cognitive functional capacity of individuals with PD	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal da Paraíba-	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3rvfwt	<NULL>	The study included individuals with clinical diagnosis of PD, of both sexes, with clinical diagnosis of PD, with staging of PD between 1 and 3 on the Hoehn and Modified Yahr scale, who are assisted by SUS, and who agree to participate in the study.	Excluded from this study were: Individuals with PD associated with another chronic neurodegenerative disease; diagnosed with parkinsonian syndrome; individuals with a history of epilepsy; carriers of another disabling condition; and to participate in other physical therapy interventions; have previous experience with Kinect; individuals with functional deficit that makes it impossible to perform the practice proposed by Kinect.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8ym9yj	Improvement in the quality of surgeon&apos;s hand preparation to prevent Surgical Site Infection in cardiac, thoracic and orthopedic surgeries.	Data analysis completed	Intervention	2020-01-02	<NULL>	<NULL>	3316	Promoting quality of Surgical Hand Preparation with Alcohol Solution for prevention of Surgical Site Infection in thoracic, cardiac and orthopedic surgery	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	World Health Organization Implementation Research Regional Training Centre for the Americas’ Region	https://ensaiosclinicos.gov.br/rg/RBR-8ym9yj	<NULL>	Being a surgeon of cardiac  and orthopedic teams working in the study hospital	Do not participate in any surgical procedure in one of the study stages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5hh9q5	Comparison between tibial nerve stimulation and  vaginal stimulation to treat urinary loss in elderly women	Data analysis completed	Intervention	2019-11-28	<NULL>	<NULL>	3320	Comparison between Transcutaneous Tibial Nerve Eletrical Stimulation and Transvaginal Eletrical Stimulation to treat Urge Urinary Incontinence in elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-02	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5hh9q5	<NULL>	Women; with 60 years old or more; complaining of urgency urinary incontinence; assisted at the Clinic of Urogynecology at Hospital São Lucas da Pucrs.	Patient complaining of stress urinary incontinence exclusively; genital prolapse above the second stage of the POP-Q classification; patients with pacemakers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-2c9tcq	Strength, blood pressure and blood glucose levels in various groups	Data analysis completed	Observational	2020-01-03	<NULL>	<NULL>	3324	"Effects of different levels of resistance training intensity in relation to the
physical, hemodynamic and glycemic capacities of different groups"	<NULL>	0, n/a, n/a	0	<NULL>	<NULL>	<NULL>	2018-02-06	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-2c9tcq	<NULL>	TTo be included in the study participants are 60 years or older; participate in regular recreational activities twice a week; do not participate in structured resistance training for less than six months prior to the commencement of the study;present a medical certificate on the project application.	To be included in the final analyzes; participants had to perform 80% of all training sessions; participate in the collections before and after the training sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-3z3qd6	Effectiveness of TENS in vocal therapy of women with vocal disorders	Data analysis completed	Intervention	2020-01-03	<NULL>	<NULL>	3326	The effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) in vocal therapy of dysphonic women: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z3qd6	<NULL>	complaint of vocal alteration; altered voice evidenced by a speech-language auditory perceptual pre-assessment; bilateral vocal nodules or mucosal thickening or edema and glottic cleft on phonation; not having used TENS for any type of treatment	volunteers who had received speech therapy before;  over 45 years of age; who reported being or had completed menstrual flow; who reported any general neurological alterations; thyroid gland changes, who had undergone clinical treatment for hormonal control (except contraceptive pill); vocal or surgical laryngeal treatment; heart problems, high blood pressure, hyper or hypothyroidism; smokers; alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4nj4db	General anesthesia with or without thoracic infiltration of anesthestics. How can we improve the quality of postoperative recovery of breast cancer surgeries	Data analysis completed	Intervention	2020-01-06	<NULL>	<NULL>	3334	General anesthesia with or without thoracic wall blocks. How can we improve the quality of postoperative recovery of breast cancer surgeries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-04	Faculdade de ciências médicas da universidade estadual de campinas	Faculdade de ciências médicas da universidade estadual de campinas	https://ensaiosclinicos.gov.br/rg/RBR-4nj4db	<NULL>	Patients under 18 and 85 years old; elective oncologic breast surgeries, ASA score 1,2,3 ; able to comprehend and respond questions and the Numerical pain scale.	patient refuse; hipersensibility of anesthetics; anatomic impossibility to do the blocks;difficult airway; unable to complete the questions; contraindications of regional anesthesia (coagulopathy, infections on the site of the blocks).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7thswq	Effects of Vagus Nerve Electric Stimulation  upon the autonomic nervous system, cardiac function and inflammation in patients with the Metabolic Syndrome	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	3339	Effects of Vagus Nerve Transcutaneous Electric Stimulation on autonomic, hemodynamic and inflammatory markers in patients with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade Nove de Julho-UNINOVE	Universidade Nove de Julho-UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7thswq	<NULL>	"Elected individuals met all the criteria listed below:
Diagnosis of Metabolic Syndrome based on newly established criteria - three abnormal findings out of five qualify a person for the diagnosis of Metabolic Syndrome:
Waist circumferential increase ( equal to or greater than 102cm in men; equal to or greater than 88cm in women);
Increased triglycerides (equal to or higher 150 mg/dL);
Reduced HDL-C (equal to or less than 40mg/dL in men; equal to or less than 50mg/dL in women);
Increased blood pressure (systolic equal to or higher 130mmHg); and/or diastolic equal to or higher 85mm Hg);
High fasting blood glucose (equal to or higher 100mg / dL);
Patient declaration of stable weight and diet for at least six months until study entry;
Normal renal function;
Normal thyroid function;
Able to declare written consent and compliance with study taxation along the study."	"Subjects were not eligible to participate in the study if they met any of the exclusion criteria listed below:
On antidiabetic medication or with HbA1c greater than 8.0%;
Triglyceride levels equal or greater than 400mg / dL or on lipid-lowering medication;
Serum alanine transaminase (AST) and / or aspartate transaminase (ALT) levels higher than 200U / L;
Resting systolic pressure greater than or equal to 160 mm Hg; resting diastolic pressure greater than or equal to 100 mm Hg;
Using antihypertensive drugs that interfere (beta blockers) with HRV;
History of debilitating chronic diseases;
Pregnancy;
Volunteers presenting any active neoplasm; cutaneous lesion and / or sensitivity deficit of the left auricle; being on radiotherapy and / or chemotherapy and immunosuppressive treatment, patients with chronic infectious diseases (including hepatitis, Acquired Immunodeficiency Syndrome)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-5h8z7h	Cosmetic Acupuntura for reduction facial wrinkles	Data analysis completed	Intervention	2020-01-09	<NULL>	<NULL>	3345	"Acupuncture applied to facial aesthetics for
wrinkles of expression: clinical trial"	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-02-10	Cristiane Garcia sanchez	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5h8z7h	<NULL>	women; aged between 40 and 64 years; wrinkles  grade II or III by the Glogau scale.	facial esthetic surgery; application of Botox, laser in the last six months; lesions on the face, pregnant women, in use of anticoagulant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-9qm2y5	Needle-less anesthesia compared to conventional: clinical trial	Data analysis completed	Intervention	2020-01-09	<NULL>	<NULL>	3348	Comparative Analysis between the Atraumatic and Conventional Anesthetic Technique in Third Molar Removal Surgery:Randomized Clinical Trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-04-01	CESMAC- Centro de Ensino Superior  Maceió	CESMAC- Centro de Ensino Superior  Maceió	https://ensaiosclinicos.gov.br/rg/RBR-9qm2y5	<NULL>	Patients of both genders, systemically healthy, aged between 18 and 45 years and need to remove the contralateral third molars, which were in symmetrical position.	Patients with a history of anesthesia or vasoconstrictor allergy employed, with third molars in non-symmetrical position or who had used anti-inflammatory, analgesic or antidepressant prior to surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-7ft6xd	The Influence of Music Associated with Insulin Use on Heart Control of Diabetic People	Data analysis completed	Intervention	2020-01-10	<NULL>	<NULL>	3353	The Influence of Musical Auditory Stimulation Associated with Insulin Use on Cardiac Autonomic Control of Diabetic People	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-13	Faculdade de Juazeiro do Norte	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-7ft6xd	<NULL>	Age between 18 and 60 years; Insulin-dependent diabetics.	Smokers; individuals with cardiorespiratory disorders; neurological; hearing impairment and other known impairments that prevent the subject from performing the procedures; Persons receiving medication that influence cardiac autonomic regulation; Patients with diabetic neuropathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-7x28v3	Effects of isolated versus combined perineal preparation methods on perineal stretching and muscle strength	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	3379	Effects of isolated versus combined perineal preparation methods on perineal distensibility and muscle strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-29	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7x28v3	<NULL>	Pregnant women at the 33rd gestational week, in the age group 18-40 years, both primiparous and women who experienced miscarriages before the 21st week of previous pregnancies, who presented muscle strength &gt; 1 (based on the modified Oxford Scale) and who were subjected to vaginal palpation.	Participants who missed two consecutive interventions, who had urinary tract infections during the study and whose pregnancy came to an end before the last evaluation were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8s9y2q	Effect of chest tube insertion site on pulmonary function in patients undergoing cardiac surgery	Data analysis completed	Intervention	2020-01-20	<NULL>	<NULL>	3380	Effect of chest tube insertion site on ventilatory function in patients undergoing elective myocardial revascularization surgery: a clinical trial	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2014-07-31	sandra simon	Fundação Universitária de Cardiologia do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8s9y2q	<NULL>	Patients aged 40 to 80 years; indication for myocardial revascularization surgery with left internal thoracic artery graft and associated pleurotomy	Severe neuropsychiatric deficit; requiring other parallel surgical interventions; with no indication for pleurotomy; symptomatic abdominal hernias; previous diagnosis of stroke or any other conditions that prevented the performance of the manovacuometer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-96g5cq	"Comparative study of Dexamethasone associated with
Nimesulide and Dexamethasone plus Paracetamol in
control of Pain, Swelling and postoperative Oral Opening Difficulty"	Data analysis completed	Intervention	2020-01-20	<NULL>	<NULL>	3385	"Comparative study between Dexamethasone co-administered with
Nimesulide and Dexamethasone co-administered with Paracetamol in
postoperative Pain control, Edema and Trismus"	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2017-06-20	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-96g5cq	<NULL>	"Voluntary patients, coming from spontaneous demand from the Unified Health System (SUS), attended at the dependencies of the UERN Dentistry Course;
Between 16 and 45 years old;
Agree to participate in research after reading the Informed Consent Form (ICF);
Classified according to the American Society of Anesthesiology (ASA), in group I (normal healthy, with no systemic changes or continuous use of medications);
With indication of lower third molar extraction, bilaterally. These, necessarily, with the same degree of inclusion as compared to their contralateral, following the classifications of Pell and Gregory and Winter."	"Report having had unpleasant previous experiences (reactions or allergic processes) to any of the drugs used in this research;
Use concomitant medication (except for oral contraceptives);
Do not fit into the planning of surgical and anesthetic techniques;
Not returning for the second surgery, (surgery on the opposite side);
Do not return to the assessments;
Inability to answer the questionnaires;
Do not correctly fill in the evaluation forms."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-83vb6b	The effect of resistance exercise with instability in the patients with Parkinson&apos;s disease	Data analysis completed	Intervention	2018-06-28	<NULL>	<NULL>	3395	Effects of resistance training with instability on clinical outcomes, Spinal Mechanisms, and Brain Metrics in individuals with freezing of gait in Parkinson’s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-25	Escola de Educação Física e Esporte da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-83vb6b	<NULL>	All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional; All patients must present the clinical diagnosis of Parkinson&apos;s disease obtained by a neurologist; to present freezing of the gait; to present between 49 and 85 years of age; to present Parkinson&apos;s disease between stages 3 and 4 and  do not perform regular exercise weights six months before starting the training intervention.	Patients who present symptoms of dementia; depression; joint problems; cardiovascular diseases (except hypertension) and claustrophobia will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-6p37zr	Evaluation of the contribution of lupus in the distribution of statins to the liver.	Data analysis completed	Intervention	2020-01-27	<NULL>	<NULL>	3407	Evaluation of the effect of systemic lupus erythematosus on the activity of the OATP1B1 transporter using atorvastatin PK-PD.	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirào Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6p37zr	<NULL>	"Healthy Volunteers Group: no active chronic kidney disease; no clinical and laboratory evidence of inflammation; no diagnosis of lupus; age between 18 and 40 years; BMI less than 30 kg / m2; women; normal liver function (birubins, AST, ALT and Gamma-GT); normal renal function (serum urea and creatinine dosage).

Uncontrolled SLE Patients Group: SLEDAI scores between 6 and 12; no active chronic kidney disease; with clinical and laboratory evidence of inflammation; age between 18 and 40 years; BMI less than 30 kg / m2; women; normal liver function (birubins, AST, ALT and Gamma-GT); normal renal function (serum urea and creatinine dosage).

Controlled SLE patients group: SLEDAI scores between 0 and 5; no active chronic kidney disease; with clinical and laboratory evidence of inflammation; age between 18 and 40 years; BMI less than 30 kg / m2; women; normal liver function (birubins, AST, ALT and Gamma-GT); normal renal function (serum urea and creatinine dosage)."	History of severe chronic obstructive pulmonary disease; healthy patients or volunteers treated with MDR1, OATP1B1 and CYP3A inducers or inhibitors.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-35nvnj	Exploratory study to assess blood sugar control through the continuous use glucose monitor in patients with type 2 diabetes treated with basal insulin randomized to insulin glargine 300u / ml or glargine 100 u / ml been a 21 week single site study open with parallel arms	Data analysis completed	Intervention	2020-01-28	<NULL>	<NULL>	3410	Exploratory study to assess glycemic control through CGM in patients with type 2 diabetes treated with basal insulin randomized to insulin Glargine 300U / ml or Glargine 100 U / ml: a 21-week single site study with parallel arms.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2017-04-24	CPCLIN - Centro de Pesquisas Clinicas LTDA	CPCLIN - Centro de Pesquisas Clinicas LTDA	https://ensaiosclinicos.gov.br/rg/RBR-35nvnj	<NULL>	"Subjects with type 2 diabetes greater than 18 years of age with 1 or more oral antidiabetic agents (metformin and / or sulfonylurea) and NPH baseline insulin for at least 6 months;

HbA1c between ?7.5% and ?11%);

Capable and agreeing subjects to perform capillary glycemia;

Subjects who were able and who agreed to use CGM during the study;

Subjects who signed an Informed Consent Form."	"Under 18 years of age;

Subjects with type 1 diabetes mellitus

Subjects on an insulin regimen at baseline / bolus or pre-admixture or with another oral antidiabetic other than metformin or sulphonylurea.

History of hypoglycemia without symptoms.

Known hypersensitivity to insulin glargine or to one of its excipients

Carrier of any clinical condition including alcohol abuse or psychiatric condition) or known illness that prevents the subject from adhering to the protocol.

Use of systemic glucocorticoids for 2 weeks or longer than 12 weeks prior to screening (excluding topical or inhaled).

Pregnant or breastfeeding women

Women who do not want contraception.

Participants from another clinical study.

Subject with a history of cancer in the last 5 years except for basal cell cancer

Company employees

Night workers"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-4d4q42	Analysis of the order of a Concurrent Exercise Session of the Blood Pressure of controlled Hypertense Elderly	Data analysis completed	Intervention	2020-01-28	<NULL>	<NULL>	3413	Analysis of the order of a Concurrent Exercise Session of the Blood Pressure of controlled Hypertense Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Programa de Pós-graduação em Ciências da Saúde	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4d4q42	<NULL>	To participate in the study, the elderly should meet the following inclusion criteria: male between 60 and 80 years old; do not exercise regularly and systematically for at least three months; do not present with musculoskeletal problems or cardiovascular complications that prevent physical exercises; present a medical certificate proving that you are fit for physical exercise; do not have a history of stroke or acute myocardial infarction; do not make use of smoking; not diagnosed with diabetes mellitus; do not exercise during the evaluation period; no pacemaker.	To exclude the study participant, he / she should: have some cardiovascular complication during the collections; not attending all evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-35htgn	Evaluation of the permanence of the posterior fat to patella in the placement of the Total Prosthesis of the Knee	Data analysis completed	Intervention	2020-01-29	<NULL>	<NULL>	3426	The influence of preservation of retropatellar fat pad on the positioning of the tibial component in Total Knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-35htgn	<NULL>	Voluntary patients  above 55 years; both sexes; patients with osteoarthrosis primary	Patients with inflammatory joint disease; patients with a history of previous knee surgery and failure to undergo imaging.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-7qnprq	Clinical evaluation of new local anesthetics for oral application	Data analysis completed	Intervention	2020-01-30	<NULL>	<NULL>	3431	Efficacy and pharmacokinetics of new topical local anesthetic formulations for the oral mucosa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7qnprq	<NULL>	Age 20 to 45 years; Healthy; Students form graduation or post graduation from Universidade São Francisco or Universidade Estadual de Campinas; only the subjects having the upper right canine free of caries, large restorations, periodontal disease, past endodontic treatment, oral mucosal with no trauma or sensitivity were included.	Allergy to local anesthetic; cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and hematological diseases, psychiatric disorders; use of any medication, except oral contraceptives one  week prior or during the experiment; smokers; addictive behavior with drugs or alcohol; pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-35mp4q	Study of the role of hydroxychloroquine in immunological and coagulation control  in patients diagnosed with Primary antiphospholipid syndrome	Data analysis completed	Intervention	2020-01-31	<NULL>	<NULL>	3433	Study of the role of hydroxychloroquine in immunomodulation and control of hypercoagulability in patients diagnosed with Primary antiphospholipid syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-11	Hemocentro- Universidade Estadual de Campinas	Hemocentro- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35mp4q	<NULL>	Confirmed diagnosis of primary antiphospholipid syndrome with thrombosis; age between 17 and 65 years old	Diagnosis of active neoplasia; presence of other associated autoimmune diseases; gestational period; antiphospholipid syndrome with isolated obstetric complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-4qfkt7	Phonological processing skills training (phonological awareness, working memory and rapid naming) and study of long-latency hearing potential (P300) in children with reading and writing difficulties	Data analysis completed	Intervention	2020-01-31	<NULL>	<NULL>	3434	"Study of Long Latency Auditory Evoked Potential (P300) pre and post intervention
on phonological processing in children with Reading and Writing Disorder"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	FAculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulos	https://ensaiosclinicos.gov.br/rg/RBR-4qfkt7	<NULL>	School children with diagnostic hypothesis of written language disorder (reading and writing problems); schoolchildren with neuropsychological diagnosis with upper and middle IQ; students attending the fourth, fifth, sixth or seventh grade of elementary school	Absence of consent of the responsible for the data collection; lower and lower average intelligence quotient; not attending school regularly; presence of syndromes that impair the cognitive part; presence or history of neurological disorders that impair cognition; hearing loss of some kind (conductive, sensorineural or mixed) or degree (mild, moderate, severe, profound) considering frequencies from 500Hz to 4000Hz; be in any therapy that involves learning and cognition (speech therapy, occupational therapy, psychopedagogy, tutoring, psychology or others)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-37r3s2	Vocal and Communication Skills for Public Speaking in University Students	Data analysis completed	Intervention	2018-09-13	<NULL>	<NULL>	3444	Promotion of Vocal and Communication Skills for Public Speaking in University Students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-37r3s2	<NULL>	Undergraduate students; ages between 18 and 30 years old; signed informed consent form	The following are excluded  from the sample: individuals who regularly practice an activity which involves speaking in public (work with public attending, attend to regular group reunions, etc.); individuals with previous training (oratory courses or similar); individuals who possess a psychological or medical diagnosis of social anxiety disorder or social phobia; present accentuated hormonal alterations, known or during the tests; present a frequency of less than 75% in the interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-5vyd2x	Evaluation of the use of Mirena IUD  in patients with increased uterine bleeding with blood clotting disorders.	Data analysis completed	Intervention	2020-02-03	<NULL>	<NULL>	3447	Evaluation of the use of the Levonorgestrel-releasing Intrauterine Device to control Abnormal Uterine Bleeding in patients with hereditary coagulopathy.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade de Medicina-Universidade Federal de Minas Gerais	Faculdade de Medicina-Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5vyd2x	<NULL>	Participants were women previously diagnosed with inherited coagulopathies presenting excessive menstrual bleeding	Myomatosis; use of anticoagulants; uterine malformations; contraindications to the use of levonorgestrel device	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-3mr2vm	Effectiveness of abdominal compression maneuver on neck vein distention and its influence on intra-abdominal pressure and on cardiac functioning of mechanically ventilated children	Data analysis completed	Observational	2019-10-10	<NULL>	<NULL>	3451	Effectiveness of hepatic compression maneuver on internal jugular vein distention and its influence on intra-abdominal pressure and cardiac index of mechanically ventilated children	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital das Clínicas da Universidade Estadual de Campinas	Hospital das Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3mr2vm	<NULL>	Age between 28 days and 14 years old; need for central venous catheterization due to the clinical condition that justified the hospitalization; presence of bladder catheter that allows IAP measurement; patients with clinical criteria for IAP monitoring due to the risk of abdominal hypertension caused by the disease that justified their hospitalization; patients under invasive mechanical ventilation with tidal volume between 8 and 10 ml / kg of ideal weight and mean airway pressure between 8 and 12 cmH20; hemodinamically stable patients defined as age-appropriate heart rate and blood pressure (between the 10th and 90th percentiles); patients with respiratory stability defined as age-appropriate respiratory rate and arterial O2 saturation greater than 94% as measured by pulse oximetry; availability of the researcher responsible for performing the ultrasound exam.	Previous venous thrombosis in internal jugular veins; presence of collateral venous circulation in the cervical region in patients with a history of previous internal jugular vein catheterizations; Initial intra-abdominal pressure greater than 12 mmHg; peritoneal dialysis; skin lesions in the right upper quadrant of the abdomen; skin lesions in the cervical region; continuous dobutamine infusion at doses greater than 5 mcg / kg / min, adrenaline at doses greater than 0.1 mcg / kg / min, noradrenaline at doses greater than 0.1 mcg / kg / min, or milrinone at doses greater than 0.25 mcg / kg / min; intense psychomotor agitation impairing ultrasound examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8yxz44	Evaluation of condylar position, angulation and morphology in patients submitted to surgery orthognathic surgery	Data analysis completed	Intervention	2020-02-06	<NULL>	<NULL>	3452	Evaluation of position, angulation and morphological aspects of the condylar process in patients submitted to surgery	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-18	Faculdade de Odontologia de Araraquara - FoAr - Unesp	Clinica de Radiologia Odontologica Radio.com	https://ensaiosclinicos.gov.br/rg/RBR-8yxz44	<NULL>	patients older than sixteen years; second to second molars present in both arches; and in need of orthognathic surgery with previous orthodontic preparation.	patients with craniofacial anomalies; systemic arthritis; muscular diseases; history of facial trauma; previous TMJ surgery; facial asymmetry; severe condylar bone resorptions; immunological diseases; pathologies that can cause condylar hyperplasia and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-6zk87m	Brief Group Intervention to reduce alcohol use in men	Data analysis completed	Intervention	2020-02-09	<NULL>	<NULL>	3463	Brief group intervention to reduce alcohol use in men: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-25	Escola de Enfermagem Universidade de São Paulo	Escola de Enfermagem Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6zk87m	<NULL>	Men be over 18 years of age; who know how to read and write; and that they score AUDIT between 8 and 19.They should be classified as well risk use or harmful use of alcohol.	Being in treatment or attending a group related to the use of alcohol; be a carrier of cognitive disability that impedes the understanding of the terms of the research; being intoxicated or under the effect of some psychoactive substance; not have a telephone or home address.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7by76r	Effects of &quot; Anti-stress Therapy&quot; on behavior and stress hormones in infertile women and also on weight loss after diet and exercise guidance in those overweight	Data analysis completed	Intervention	2016-04-25	<NULL>	<NULL>	3472	Effects of &quot; Mind Body Therapy&quot; on behavioral and neuroendocrine markers of stress in infertile women and also on reducing the body mass index after diet and exercise guidance in those with overweight and obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-02	Hospital das Clínicas da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7by76r	<NULL>	Infertility; policystic ovarian syndrome; uterus, tube and/or ovarian disfuctions; overweight; obesity.	Refuse to sign the Informed Consent; give up the project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-6wnw9t	GRAU: Group-based therapy for anxiety reduction among university students	Data analysis completed	Intervention	2020-02-11	<NULL>	<NULL>	3473	GRAU: Group-based interventions for the treatment of anxiety among university students with Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-6wnw9t	<NULL>	Inclusion high anxiety. Moderate depression. No risk of suicide.	Exclusion Low level of anxiety.High level of depression. High risk of suicide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-5n9c8q	Evaluation of dental extraction made with the less traumatic instrument	Data analysis completed	Intervention	2020-02-11	<NULL>	<NULL>	3476	Evaluation of exodontic technique with minimally traumatic extractor	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-09	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5n9c8q	<NULL>	Presentation of at least one residual root or indication of extraction; teeth severely destroyed by caries or fracture to the point of rendering their restoration unfeasible; prosthetic, periodontal or orthodontic indication; teeth of the jaw or jaw; incisors, canines and premolars; agree to participate in the study by signing the TCLE.	Patients with any factor that contraindicated the surgical act; infection installed on site; uncontrolled systemic disorders; diabetes and hypertension; problems in the coagulation cascade; severe anemia; allergies; patients who used some medicine with interference in bone metabolism; pregnant patients; patients who used drugs that stimulated gingival augmentation; asthmatic patients without the opinion of the pulmonologist; patients who had recently had Chikungunya; patients who were not involved in the planning of surgical and anesthetic techniques; not return to data collection; give up participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-65d7cc	Prospective clinical study about gingival inflammation in teeth treated with dental contact lenses without cervical preparation. Evaluation by clinical parameters and inflammatory mediators present in the gingival fluid.	Data analysis completed	Intervention	2020-02-12	<NULL>	<NULL>	3481	Ceramic veneers cemented on no prep teeth. Prospective and longitudinal clinical study of marginal adaptation and evaluation of periodontal behavior using biomarkers of gingival crevicular fluid	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-05	Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-65d7cc	<NULL>	Healthy patients who needed ceramic lveneers in the region between teeth 15 to 25; with healthy teeth and in good condition of periodontal health attested by clinical and radiographic examination; with the need to close diastemas; elimination of black spaces; corrections of shape and dental contour with aesthetic and / or functional justification attested by diagnostic waxing.	Periodontal disease active at the time of screening; structural damage to gingival architecture; pregnancy; diabetes mellitus; autoimmune diseases; other uncontrolled systemic changes with a damaging effect on gingival tissues; continuous medication users; presence of hormonal or vitamin deficiency; patients with a history of recent use of anti-inflammatories or antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-2sm5nx	Prospective clinical study about the post-operative dental hypersensitivity of teeth restored with ceramic veneers	Data analysis completed	Intervention	2020-02-12	<NULL>	<NULL>	3483	Longitudinal clinical study of teeth restored with metal-free ceramic systems. Prospective study about the post-operative dental hypersensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-10	Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-2sm5nx	<NULL>	Individuals who required ceramic restorations in the region of the 2nd right premolar to the left 2nd premolar of the maxillary arch were selected, of both sexes and varied ages, with vital teeth and good condition of periodontal health attested by clinical examination.	Patients who made continuous use of analgesics and / or anti-inflammatory drugs were excluded, as such drugs could mask the results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-5n2x5v	The value of Gadoxetic Acid as a hepatobiliary-specific contrast agent in Magnetic Resonance Imaging in the assessment of focal liver lesions	Data analysis completed	Intervention	2020-02-13	<NULL>	<NULL>	3490	The value of Gadoxetic Acid as a hepatobiliary-specific contrast agent in Magnetic Resonance Imaging in the assessment of focal liver lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-03	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5n2x5v	<NULL>	Magnetic resonance imaging of the abdomen using gadoxetic acid as a contrast agent in the assessment of focal liver lesions that had already been identified in previous examinations (ultrasound, computed tomography or magnetic resonance with conventional gadolinium), but which still remained undetermined, requiring complementation diagnostics, performed at the HC of FCM / UNICAMP, from January 2015 to December 2018	Absence of definitive diagnostic criteria for focal liver lesions; radioablation and / or chemoembolization prior to the lesion to be analyzed; examination artifacts preventing adequate characterization of the lesion to be analyzed; absence of detection of the focal lesion in the MR examination; age under 18 and over 78	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-4qqbps	"Use of auriculotherapy in the treatment of problems arising from Chikungunya:
An approach to primary care"	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3491	Auriculotherapy in patients with sequelae of Chikungunya Fever: An approach in primary care	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Escola Multicampi de Ciências Médicas	Escola Multicampi de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-4qqbps	<NULL>	Seniors aged 60 and over; both sexes; proper locomotion; report pain; registered in health institutions.	Cognitive deficit; disabling neurological deficits; refuse to respond to the assessment tools; non-attendance at scheduled appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-2xdpsr	Body Composition and Renal Function in Kidney Transplant Recipients: comparison between combined training and usual care.	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3494	Quality of life, functional capacity, body composition and heart rate variability in Kidney Transplant recipients undergoing Physical Exercise Program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-2xdpsr	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7q63c4	Association between Low Level Laser Therapy and a protocol of Physical Exercises in pacients with knee Osteoarthritis	Data analysis completed	Intervention	2020-02-17	<NULL>	<NULL>	3495	Association between phototherapy and a protocol of Physical Exercises in pacients with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7q63c4	<NULL>	women aged 55 to 75 years; with knee osteoarthritis grades II or III on the Kellgren and Lawrence scale confirmed by radiological examination; with cognitive ability to understand the study according to the cut-off score of the Mini Mental State Examination; and classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version (IPAQ).	Presence of cardiovascular desease; presence of neurological desease; presence of musculoskeletal disease that makes it impossible to perform the exercise protocol; use of conventional treatment; use of unconventional treatment; use of alternative treatments that may interfere with the results of the study (physical therapy treatment and / or injections of intra-articular corticosteroids or hyaluronic acid during the last 3 months); absolute contraindication for photobiomodulation, such as the presence of neoplasia in the lower limbs region; and individuals who have malnutrition (BMI less than 18.5) or morbid obesity (BMI equal or more than 40).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-283byt	At-home bleaching with WhiteClass 10%, applied on the palatal face, is effective	Data analysis completed	Intervention	2020-02-19	<NULL>	<NULL>	3503	Effectiveness of at-home bleaching with 10% Hydrogen Peroxide applied on the palatal face. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-283byt	<NULL>	Volunteers between 18 and 40 years old; no systemic diseases; without caries; no periodontal diseases; having at least two central incisors or canines with a color C2 or darker; with the six upper anterior teeth free of restorations on the palatal and buccal surfaces; sound enamel; without pathological, physiological and drug alterations	Volunteers with orthodontic braces; severe crowding; presence of intrinsic spots; taking anti-inflammatory drugs; smoker; alcoholist; pregnant women; lactating women; patients who report severe sensitivity during treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-72cyh7	Analysis of the effectiveness of different root canal treatments in the reduction of bacteria and their products	Data analysis completed	Intervention	2019-02-25	<NULL>	<NULL>	3508	Analysis of the effectiveness of endodontic procedures in the reduction of microorganisms and their by-products	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2016-10-15	Faculdade de Odontologia de Araçatuba - Unesp	Fundação de Amparo à Pesquisa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72cyh7	<NULL>	A total of 24 patients who presented with primary endodontic infection were included in this study. The teeth selected should have a primary endodontic infection, with absence of spontaneous painful symptomatology, absence of periodontal pocket with a depth greater than 4 mm, and that could be isolated with a rubber dam.	Those who received antibiotic, anti-inflammatory or analgesic treatment in the last three months or who had any uncontrolled generalized disease were excluded from work.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-54g48y	Comparison between intravenous Methadone and Morphine on the quality of anesthesia recovery after stomach reduction surgery	Data analysis completed	Intervention	2019-02-01	<NULL>	<NULL>	3512	Effect of intravenous Methadone compared to Morphine on the quality of anesthesia recovery after laparoscopic gastroplasty surgery: prospective, randomized and controlled clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-01-21	Financiamento próprio.	Financiamento próprio.	https://ensaiosclinicos.gov.br/rg/RBR-54g48y	<NULL>	Patients included in the study protocol should meet the following criteria: age between 18 and 65 years; body mass index (BMI) &gt; 40 kg / m2 regardless of the presence of comorbidities or BMI between 35 and 40 kg / m2 in the presence of comorbidities; framed in the ASA (American Society of Anaesthesiologists) from I to III; submitted to videolaparoscopic gastroplasty surgery under general anestesia; expected hospital stay of up to 36 hours.	It will be excluded from the study protocol the patients who: refuse to participate of the proposed study; have history of adverse reactions to any drug included in the study protocol; have history of alcohol or illicit substances abuse; are chronic users of opioids for various reasons; have hepatic or renal failure; need for conversion from laparoscopic surgery to laparotomy; concomitant surgical approach on other surgical site; have the presence of coexisting diseases that impair cognitive ability; have the presence of poorly controlled psychiatric illnesses; and have retarded neuropsychomotor development.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-523n7r	Effect of simvastatin 20mg in bone formation after Removal of lower third molar teeth	Data analysis completed	Intervention	2020-02-20	<NULL>	<NULL>	3519	Efficacy of simvastatin 20mg on bone regeneration after lower third molar extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-08	Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-523n7r	<NULL>	The inclusion criteria were as follows: adult patients aged between 18-40 years old, of both genres, of any ethnicity, healthy, without allergy to the drugs used in the research or its components and who are not using any other medication. All patients must have both lower third molars, included, with the same inclusion pattern according to the Pell &amp; Gregory classification, healthy, with indication of extraction and without signs of pericoronitis or inflammation.	The exclusion criteria were: patients with an inability to open their mouth for surgery; exceed 40 minutes in any surgery; fracture or postoperative infection; recent history of chemotherapy and / or radiation to the head and neck; giving up participating in the research at some point; make use of medications that have a known interaction with any drugs used in the study; smokers, pregnant or lactating women; did not perform the tests requested in the postoperative period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-6gy3ss	Effects of acute supplementation with Whey Protein and Collagen on the appetite in humans	Data analysis completed	Intervention	2020-02-20	<NULL>	<NULL>	3521	Effects of acute supplementation with Whey Protein and Collagen on the appetite in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6gy3ss	<NULL>	The study population consisted of women with a Body Mass Index (BMI) above 18.5 kg / m2 and less than 25.5 kg / m2 and aged between 18 and 35 years.	Women diagnosed with autoimmune diseases or using immunosuppressive drugs were excluded from the research; with clinical diagnosis of diabetes, thyroid dysfunction, chronic kidney disease or liver disease; who underwent bariatric surgery prior to the research; chronic drinkers; using drugs that alter appetite or body weight (appetite suppressants) in the last twelve months; had attended food restriction programs or were using nutritional supplements in the last twelve months; manifested feverish state in the weeks of the research; failure to follow the protocol stipulated for data collection or refused to carry out any of the proposed evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-73s4x3	Efficacy of a physical therapy protocol of simultaneous tasks in the functions of elderly people who practice physical activity	Data analysis completed	Intervention	2020-02-26	<NULL>	<NULL>	3526	Effectiveness of a dual task physiotherapeutic protocol on the functionality of active elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal do Triângulo Mineiro	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-73s4x3	<NULL>	Volunteers aged 60 or over; with self-reported ability to walk at normal speed for 150 meters or more, without sitting or using support; physically active according to the International Physical Activity Questionnaire.	Sedentary volunteers; with severe cognitive impairment suggestive of dementia according to the Mini Mental State Examination; with significant or chronic orthopedic pain and joint deformities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-9mj2dt	Effects of probiotics consumption for teratment of arterial hypertension	Data analysis completed	Intervention	2020-02-27	<NULL>	<NULL>	3536	Effects of supplementation with Probiatop (mixture of probiotics) in the treatment of arterial hypertension	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2017-08-03	FarmoQuímica	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9mj2dt	<NULL>	women diagnosed with primary systemic arterial hypertension (SAH) and aged 20 to 50 years.	"Age &lt;20 and&gt; 50 years;
Smoking;
Patients with other associated morbidities with the exception of Diabetes Mellitus;
Patients with a history of angina, acute coronary syndrome, changes in
left ventricular ejection fraction;
Patients with changes in liver enzyme levels or kidney failure
(creatinine&gt; 1.5 mg / dL);
Use of medications other than antihypertensives or
hypoglycemics;
Patient undergoing steroid or anticoagulant treatment, using
food supplements, with infections or neoplasia or other chronic pathology
known;
Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-235jx7	Impact of Dietary Composition and Resistance Training on Cardiovascular Risk Indicators and Android Adipose Tissue in Elderly Women	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3541	Study of Randomized Nutritional Intervention in Overweight Elderly People with Strength Training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-235jx7	<NULL>	Overweight or obese elderly women (BMI&gt; 25kG / M²), elderly women who can eat high protein diets (without chronic kidney disease), elderly women without physical limitations (able to perform strength training) and elderly women without mental limitations or psychological (ensuring adequate understanding of nutritional guidelines), as well as elderly women who signed the consent form.	Elderly women with BMI &lt;25kG / M², elderly women who cannot eat high protein diets (chronic kidney disease patients), elderly women with physical limitations (unable to perform strength training) and elderly women with mental or psychological limitations ( ensure adequate understanding of nutritional guidelines), as well as older women who refused to sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4dbvt7	Effectiveness of bleaching using violet led light	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3544	Effectiveness of bleaching with led photobleaching: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal do Amazonas - Faculdade de Odontologia	Universidade Federal do Amazonas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-4dbvt7	<NULL>	Patients will be included in this clinical trial were men and women over 18 years; who were in good general and oral health; were required to have six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade C2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients will be excluded pregnant or lactating women; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); orthodontic appliance users; gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-8rs5kt	Myopia and Astigmatism Topography-guided Refractive Surgery by Contoura Method Versus Customized by Asphericity in Contralateral Eyes: A Prospective Double-blind Randomized Study	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3548	Femtolasik Topography-guided by Contoura Method Versus Customized by Asphericity in Contralateral Eyes: A Prospective Double-blind Randomized Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-05	Hospital de Olhos - Oftalmax	Hospital de Olhos - Oftalmax	https://ensaiosclinicos.gov.br/rg/RBR-8rs5kt	<NULL>	Patients of both sexes aged 20-35 years (avoiding possibly presbyopia patients), myopic with or without astigmatism, with stable refractive error for at least 1 year and visual acuity corrected away from 0.1 logMAR or better. The myopia may vary between -0.50 and -8.00 diopters (D) and the astigmatism between 0.00 and -3.00 cylindrical diopters (CD), with maximum spherical equivalent of 8.00D.	Patients with significant anisometropia, that is a refractive difference of 1 spherical diopter or 0.75 cylindrical diopters between the eyes, will be excluded from the study. Other exclusion criteria will be: presence of clinical signs of dry eye, abnormalities of the anterior segment - such as cataracts, scars or corneal neovascularization within 1.0 mm of the desired ablation zone, epithelial basement membrane disease, history of recurrent corneal erosions, progressive or unstable myopia, PAT (percentage of altered tissue) calculation above 35% of the corneal thickness at its finest point in the ablation calculation19,24, pachymetry below 500, suspected keratoconus in its subclinical or stablished form, macular or retinal disease, diagnosis of glaucoma or ocular hypertension, current use of systemic corticosteroids or immunosuppressive therapy, collagen diseases, vascular diseases, diabetes mellitus types I and II, pregnancy and breastfeeding. The patient who presents any type of intraoperative intercurrence will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-4hxs2g	Resistance exercise during hemodialysis session	Data analysis completed	Intervention	2020-03-02	<NULL>	<NULL>	3549	Effect of physical exercise on hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-20	Universidade Estadual Paulista &quot;Julio de Mesquita Filho&apos;	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-4hxs2g	<NULL>	Be over 18 years old; have been on hemodialysis for at least three months; patients without medical records of event, symptom or heart disease, such as acute myocardial infarction, coronary insufficiency with presence of ischemia and / or angina, arrhythmias and stroke; without medical contraindication to physical exercise.	Exclusion criteria: individuals with mobility difficulties; blind, amputated, change in hemodialysis shift, people who received kidney transplant and individuals in wheelchairs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-3sq5hv	Three-dimensional assessment of facial growth of severe upper airway obstruction children after adenoid and tonsills surgery	Data analysis completed	Observational	2020-03-03	<NULL>	<NULL>	3556	Three-dimensional assessment of facial growth of severe upper airway obstruction children after adenotonsillectomy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-09-15	Universidade Federal de Minas Gerais	Faculdade de Medicina Dentária de Lisboa	https://ensaiosclinicos.gov.br/rg/RBR-3sq5hv	<NULL>	"children with OSA diagnosed by polissonography;  
Brodsky&apos;s grade 3 or 4 palatine hypertrophy tonsils;adenoid hypertrophy above 75% confirmed by nasopharyngo-laryngoscopy;indication of adeno/-tonsillectomy"	Children with genetic syndromes and neuromuscular disease; children with a perforation of the nasal septum and/or craniofacial alterations; children diagnosed of pulmonary hypertension due to heart disease or with a previous history of adenotonsillectomy;children who could not be submitted to the examinations proposed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-7mn7yj	Effects of High Intensity Exercise Training in Patients with Chronic Obstructive Pulmonary Disease in a Pulmonary Rehabilitation Program	Data analysis completed	Intervention	2020-03-04	<NULL>	<NULL>	3566	Effects of High Intensity Exercise Training in Patients with Chronic Obstructive Pulmonary Disease in a Pulmonary Rehabilitation Program	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-09-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7mn7yj	<NULL>	with moderate to severe COPD, (post-bronchodilator FEV1&gt; 30% and predicted &lt;80%)	"Exclusion criteria were:
 indication and / or use of chronic home oxygen therapy, inability to perform physical tests, symptomatic coronary disease, musculoskeletal limitation and neurological disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-3r2kv9	Impact of the maternal diet and the supplementation of fibers on the breast milk bacteria	Data analysis completed	Intervention	2020-03-06	<NULL>	<NULL>	3569	Impact of the maternal diet and the intervention with fructooligosaccharides on the human milk microbiota	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-01	Universidade de São Paulo	Hospital Universitário da Universidade de Sâo Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3r2kv9	<NULL>	Healthy lactating women having term babies (born between 37 and 42 weeks), with adequate weight for gestational age; having normal bowel frequency (minimum once every 2 days, maximum 3 times per day).	"No chronic gastrointestinal disease; genetic disease; cardiac disease; kidney disease; hypertension; diabetes mellitus or immunodeficiency diseases; eclampsia or gestational diabetes during pregnancy; mastitis during the lactation period;
have taken proton pump inhibitors; H2 receptor antagonists; antidepressants; narcotics; anticholinergic medications; laxatives, or anti-diarrhea medications within 30 days prior to collection the milk samples; regular consumption of commercially available, prebiotic- or probiotic supplemented product."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-9s93d9	Is mindful breathing meditation worth it for obese patients under nutritional orientation? Evaluation of stress perception, anthropometry, and autonomous balance in a Brazilian sample.	Data analysis completed	Intervention	2020-03-08	<NULL>	<NULL>	3572	Association of guided meditation and nutritional orientation for obese patients.	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2017-04-04	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9s93d9	<NULL>	Female patients; with an age range between 21 and 59 years; BMI ? 30 kg/m²; who accepted to participate the study.	diagnosed Diabetes; diagnosis of any psychiatric disorder; being pregnant or suspicious of being pregnant; having a pacemaker or any other electronic devices inside of the body; having a metallic prosthesis inside of the body; or not agreeing to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-9rhyjn	Postoperative urinary retention in orthopedic patients	Data analysis completed	Intervention	2020-03-08	<NULL>	<NULL>	3573	Acute postoperative urinary retention in orthopedic patients undergoing Spinal Anesthesia with Morphine versus Spinal Anesthesia without opioid associated with Peripheral Nerve Block: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-23	Carolina Lourenzon Schiavo	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9rhyjn	<NULL>	Patients over 18 years of age; undergoing elective orthopedic surgeries of the lower limbs at the Hospital de Clinicas de Porto Alegre; with acceptance and signature of the free and informed consent term; with the possibility of performing the surgical procedure under spinal anesthesia; a minimum hospital stay forecast of 24 hours.	Patients with a history of urological problems; severe cognitive disorders;  patients who were unable to urinate spontaneously before surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-9xqcws	Traditional resistance training with no load on strength gains, hypertrophy and functionality	Data analysis completed	Intervention	2019-09-28	<NULL>	<NULL>	3593	Acute and chronic adaptations of different resistance and concurrent training protocols	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-9xqcws	<NULL>	The inclusion criterion was to be admitted to the ICU sector of two reference hospitals in Belém, from September to October 2017, to be admitted to the rehabilitation process in the Hospital wards, with a medical certificate allowing the accomplishment of kinesiotherapy	Death or do not complete intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-9wskdv	Power resistance training versus traditional on muscle adaptations and functionality in elderly woman	Data analysis completed	Intervention	2020-03-10	<NULL>	<NULL>	3598	Acute and chronic adaptations of different resistance and concurrent training protocols	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-9wskdv	<NULL>	The inclusion criteria were to be at least 60 years old; do not have any acute or chronic condition that would compromise the execution of tests and protocols, have a medical certificate and have not performed RT for at least 1 year before the study	Death or not completing the intervention protocol or withdrawal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-8p9fmn	Management of Gingival Smile using Botulinum Toxin	Data analysis completed	Intervention	2020-03-11	<NULL>	<NULL>	3604	Management of Gingival Smile using Botulinum Toxin Type A: pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8p9fmn	<NULL>	Patients aged between 18 and 40 years, who presented gingival exposure when smiling, greater than or equal to 3 mm, bilaterally.	patients with systemic impairment, a history of hypersensitivity to the toxin, immunodeficiencies or who had applied the toxin less than six months ago; patients who received treatment with aminoglycosides, anticholinergic drugs or other agents that could interfere with neuromuscular transmissions or muscle relaxants (as the effect of botulinum toxin can be enhanced); patients with neuropathic diseases of the peripheral system, sclerosis or any disorders of the neuromuscular junction due to the increased risk of clinically significant adverse reactions; patients with infection at the application site, psychologically unstable or pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-7qnxty	Effect of Self Massage on muscle strength in female soccer athletes	Data analysis completed	Intervention	2020-03-12	<NULL>	<NULL>	3612	Effect of Self-Myofascial Release on muscle strength in female soccer athletes: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Samuel Miranda Souza	Universidade Católica do Salvador	https://ensaiosclinicos.gov.br/rg/RBR-7qnxty	<NULL>	Being a female soccer athlete at Esporte Clube Vitória	Athletes who were in the process of recovering from lower limb injuries; athletes who underwent surgery in the last eight months prior to the collection period; athletes who presented some condition that would make them unable to perform the practices.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7qj2tf	Traditional resistance training and use of blood flow restriction in muscle hypertrophy and functionality gains	Data analysis completed	Intervention	2020-03-13	<NULL>	<NULL>	3613	Acute and chronic adaptations of different resistance and concurrent training protocols	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-10	Universidade Federal de Goiás	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7qj2tf	<NULL>	The inclusion criterion was to be admitted to the rehabilitation process in the hospital wards, with a medical certificate allowing the performance of kinesiotherapy in two reference hospitals in 2017. As well as been at least 50 years old	Death or do not complete intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-42nd7q	Medical Record Model Oriented to problems with the use of medications in patients with Heart Failure admitted to the Intensive Care Unit	Data analysis completed	Intervention	2020-03-13	<NULL>	<NULL>	3614	Medical Record Model Oriented to Pharmacotherapeutic Problems of Patients with Heart Failure Admitted to the Intensive Care Unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-16	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-42nd7q	<NULL>	Patients will be included: over 18 years old; who have not been transferred from the ICU to other hospitals; with an APACHE II score 20; with no current cancer diagnosis; absence of surgery in the last six months; and, who presented at least one PRM identified by the research pharmacists through the DAM medical record	We will exclude patients: with data collection beginning after the first 48 hours of hospitalization; with hospital stay less than 72 hours; who are admitted for palliative care; higher probability of early death (defined as death occurring between the 48th and 72nd hours of ICU admission); diagnosed with suspected or confirmed brain death; aware that they refuse to participate in either group after randomization; who refuse to participate in the study after recovering an adequate state of consciousness for decision-making, when their entry is made by the authorization of family members and / or guardian.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-4yq8n9	Evaluation of the use of medications in wisdom tooth extraction surgeries	Data analysis completed	Intervention	2020-03-16	<NULL>	<NULL>	3617	Drug evaluation in third molar surgeries. Blind, randomized clinical trial in divided mouth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Instituto de Ciência e Tecnologia - Câmpus de São José dos Campos	Instituto de Ciência e Tecnologia - Câmpus de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-4yq8n9	<NULL>	Patients in need of extraction of third molars, regardless of gender; presence of teeth in opposite hemiarchs with similar positions; patients aged between 15 and 40 years; patients who voluntarily agree to participate in the research, being aware of the risks and benefits, and signing the Informed Consent Form (ICF).	Patients with local or systemic changes that contraindicate the procedure; use of anti-inflammatory drugs in the last 15 days; presence of lower third molars in different position and classification of inclusion on both sides; erupted lower third molars; patients allergic to amoxicillin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-38x665	Analysis of biological blood markers after computer-based memory stimulation in adults over 45 years old attended at the memory clinic	Data analysis completed	Intervention	2020-03-16	<NULL>	<NULL>	3618	Analysis of serums neurobiomarkers  after cognitive stimulation using technology in adults over 45 years old at the Memory Clinic	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-24	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-38x665	<NULL>	Adults and elderly aged between 45 and 80 years old; assisted by the Unified Health System at the Memory Clinic at the UNISUL; Cognitive assessment performed by MoCA with a score above 12.	Individuals with dementia or with visual impairment or physical/mental condition that disallow to move at the University and attending an intervention using a desktop computer with internet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-23jx2s	Low doses of Midazolam to reduce Anxiety in Pregnant Women undergoing Cesarean Section	Data analysis completed	Intervention	2020-03-17	<NULL>	<NULL>	3622	Low doses of Midazolam to produce Anxiolysis in Pregnant Women undergoing Cesarean Section	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-06	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-23jx2s	<NULL>	Pregnant women indicated for cesarean section; aged between 18 And 40 years; physical status ASA II by the American Society of Anesthesiologists	Restriction of fetal development, fetal malformations, acute fetal distress, multiple pregnancy, acute pain, moderate to severe pneumopathies, psychopathologies that interfere with autonomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-2f8mtn	Ingestion of Cannabis oil in Fibromyalgic people	Data analysis completed	Intervention	2020-03-17	<NULL>	<NULL>	3624	Cannabis oil in Fibromyalgic people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-27	Escola de Saúde Pública de Florianópolis	Escola de Saúde Pública de Florianópolis	https://ensaiosclinicos.gov.br/rg/RBR-2f8mtn	<NULL>	Fibromyalgia diagnosis (ACR 2010 criteria); age over 18 years; ability to sign the informed consent form; presence of moderate to severe symptoms despite therapies in use; at least one medical or nursing consultation at Health Center on the last year.	Decompensated organic comorbidities and/or risk psychiatric conditions (schizophrenia, psychosis, severe personality disorder, current suicidal ideation); other well defined cause of chronic pain; current pregnancy/lactation; moderate or severe cognitive impairment; history of cannabinoids sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-54ngrx	The influence of physical activity for patients with liver cirrhosis	Data analysis completed	Intervention	2020-03-18	<NULL>	<NULL>	3627	Effect of physical exercise in cirrhotic patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-54ngrx	<NULL>	Age over 18 years; Carrier of liver cirrhosis.	Smoking; coronary disease; presence of hepatocellular carcinoma; use of vasoactive drugs (except propranolol); use of current interferon or in the last 3 months; use of corticosteroids; duration of the infectious condition; upper gastrointestinal bleeding in the last two weeks; pregnant; musculoskeletal injuries; upper digestive endoscopy with medium or large caliber esophageal varices without eradication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7mty35	Implementation Intention to reduce salt intake on Heart Failure	Data analysis completed	Intervention	2020-03-20	<NULL>	<NULL>	3635	Implementation Intention strategies to reduce sodium intake among Heart Failure patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-12	Faculdade de Enfermagem, Universidade Estadual de Campinas	Faculdade de Enfermagem, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7mty35	<NULL>	"There were included Heart Failure patients and their social referee.
For patiets the inclusion criteria were: Age over 18 years old and inferior to 85 years old; Being in clinical follow-up for at least 6 months.
For social referee: Wife/ husbund, daughters/ sons, parents, house workers or any other person who was reponsible to prepare the patients meal at home; Age over 18 years old and inferior to 85 years old; Available to go with patient to the health clinic in all phases of the study."	"Patients were excluded: With diagnosis of Hert Failure functional class IV; With recently history of being hospitalized (less than 01 month) before the study; With no condition of effective verbal communication; With diagnosis of mental disorders (described in medical report); Whose social referee who prepares meals at home could not be present at all consultations. 
For socials referee: With no condition of effective verbal communication; Wiht diagnosis of mental disorders (described in medical report); Who did not agree in participating of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-4kpbhp	Comparing three drugs for reducing heart rate and blood pressure during laryngoscopy and intubation	Data analysis completed	Intervention	2020-03-20	<NULL>	<NULL>	3639	Comparative study of iv esmolol,iv diltiazem, and iv lignocaine hydrochloride in attenuating pressure response to laryngoscopy and intubation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-12	Government medical college haldwani	Government medical college haldwani	https://ensaiosclinicos.gov.br/rg/RBR-4kpbhp	<NULL>	"Patients equal to or greater than 18 years  and equal or lesser than  60 years of age;Patients weighing equal to or greater than 40kg and equal or lesser than 90 kgs of either sex  and BMI equal to or greater than 18.5  and equal or lesser than 24.9 of either sex;Patients posted for elective Surgical Procedure belonging to ASA physical status – 
Grade I and II;Patients requiring general Anesthesia and Endotracheal Intubation."	Patient / guardian refusal for consent;ASA grade III and IV;Emergency surgeries;Patients between age greater than 60 years and Age lesser than 18 years;Patients weighing greater than 90kg and lesser than 40kg  and BMI lesser than 18.5 and  greater than 24.9;Patients suspected to have difficult tracheal intubation;Patients on beta-blockers or calcium channel blockers;Patients with significant renal (serum creatinine greater than 1.5mg/dl) ,hepatic (serum total bilirubin greater than 1.2 mg/dl, serum total protein lesser than 6g/dl &amp; greater than 8.5g/dl ,serum albumin lesser than 3.5g/dl &amp; greater than 5g/dl , serum SGPT greater than 40u/l , serum SGOT greater than 56u/l) disease;Hypertensive patients systolic blood pressure greater than 160 mmHg and or diastolic blood pressure greater than 95 mmHg;Patients with chronic obstructive lung diseases especially bronchial asthma;Diabetic patients on treatment;Patients with significant heart disease like past history of  angina or myocardial infarction , heart blocks , and congestive cardiac failure;Laryngoscopy and intubation exceeding 20 seconds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-228fsy	Evaluation of fractional CO2 laser in vaginal atrophy in menopausal women compared to topical estrogen therapy	Data analysis completed	Intervention	2020-03-25	<NULL>	<NULL>	3654	Study of vascular and cellular proliferation factor and mucous thickness in the vaginal epithelium in menopaused women submitted to vaginal rejuvenation by fractional co2 laser	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-02-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-228fsy	<NULL>	Age over 50 years;no menstruation 12 months ago;  presence of symptoms resulting from vulvovaginal atrophy, a conventional Pap smear examination of Frost consistent with atrophic status and who have not undergone hormone replacement in last 3 months	urogenital infection or inflammation of character acute or recurrent;pre-neoplastic lesions;pelvic prolapses; pregnant women; immunosuppressive patients, severe chronic diseases; previous pelvic surgery;use of hormone therapy for less than 3 months;previous pelvic radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-4r8cb9	Clinical simulation for teaching of sexuality of individuals with spinal cord injuries	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3661	Clinical simulation for teaching of sexuality of patients with spinal cord injuries	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-29	Faculdade de Enfermagem da Universidade Estadual de Campinas	Faculdade de Enfermagem da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4r8cb9	<NULL>	"Students regularly registered in undergraduate nursing courses who attended or are attending
semiology and semiotechnics / fundamentals and some discipline that contemplates the content of
Women&apos;s Health."	Students who are absent from any stage of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-2cp8t8	Evaluation of the temperature of the irrigant during root canal treatment in patients with the use of several irrigant agitation methods	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3663	In vivo evaluation of the irrigant agent temperature after shaking by easy clean, endo xp finisher and ultrasonic passive irrigation in the apical third	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-10	Geraldo Edson Freitas Athayde Moraes	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-2cp8t8	<NULL>	Health patients; both gender; no smokers; age between 19 and 58; diagnosed with pulp pathology	"Patients who did not agree with the study;
teeth with incomplete rhizogenesis;root with curvature greater than 5°; teeth with more than one root canal; teeth with previous root canal treatment; teeth with calcified root canal; teeth were it was not possible to perform the patency with K# 5 file"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-9mwft7	Social support of family caregivers of elderly people with high dependence: a quasi-experimental study	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3668	The results of an intervention on the social support of family caregivers of elderly with high dependence.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9mwft7	<NULL>	Be 18 years of age or older; Both sexes; Being a family caregiver for at least three months; Reside in the municipality of Ribeirão Preto; Own smartphone	Being a professional caregiver for the elderly; Elderly resident of LTI; Elderly not being followed up on an outpatient basis at GEAD	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-43k52n	Health education actions to improve the quality of life of adults affected by syndrome	Data analysis completed	Intervention	2020-03-26	<NULL>	<NULL>	3670	Repercussions of nursing actions with health education on the quality of life of adults affected by syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Estadual do Sudoeste da Bahia	Isleide Santana Cardoso Santos	https://ensaiosclinicos.gov.br/rg/RBR-43k52n	<NULL>	Having three clinical conditions for metabolic syndrome according to the criteria of the National Cholesterol Education Program’s Adult Treatment Panel III; being an adult aged 25 years or older up to 59 years 11 months and 29 days; not have cognitive and / or motor deficits that prevent you from responding to the instruments or taking the exams and accepting to participate in the study.	Adults with type I diabetes; adults with cognitive impairment; adult pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8x8v2r	Music in the pain of the term newborn undergoing venipuncture: Randomized Clinical Trial	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3678	Music in the pain of the term newborn undergoing venipuncture	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-09	Universidade Federal do Ceará - UFC	Hospital São Camilo Cura d'Ars	https://ensaiosclinicos.gov.br/rg/RBR-8x8v2r	<NULL>	Newborns with clinical indication of venipuncture for blood test collection; newborn with birth gestational age equal or greater than 37 and smaller 42 weeks, considering the time of amenorrhea or ultrasound performed in the first trimester of pregnancy.When the data was not available, the New Ballard evaluation methods were considered;Newborn with score on the APGAR index bulletin equal or greater than 7 in the 5th minute of life; newborn who underwent Neonatal Hearing Screening.	Newborn using drugs that interfere with pain perception (nociception), such as opioid analgesics and other types of sedatives;newborn whose mother may be breastfeeding using medications that interfere with pain perception (nociception), such as opioid analgesics; newborns undergoing surgical procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-5q4m7t	Acute effect of treadmill exercise on blood viscosity and IGF-1 protein in Alzheimer&apos;s disease	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3680	Acute effect of aerobic exercise on blood viscosity and IGF-1 in Alzheimer&apos;s disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-13	Unesp - Universidade estadual paulista	Ufabc - Universidade federal do ABC	https://ensaiosclinicos.gov.br/rg/RBR-5q4m7t	<NULL>	Older adults over 60 years of age, of both sexes; Older adults with clinical diagnosis of Alzheimer&apos;s disease, Level of mild dementia severity according to the Clinical Dementia Rating Score (CDR) (MORRIS, 1993; MONTAÑO; RAMOS, 2005). The adoption of this criterion is due to the nature of the specific procedures of the proposed physical exercise intervention protocol, which requires a certain level of understanding of the activities by the elderly. Availability to participate in the activities proposed by the researcher; Agree and sign the Free and Informed Consent Term based on Resolution 466/12 of the National Health Council.	Older adults with coronarian disease, cardiac arrhythmia, non-controlled hypertension and angina symptons or any restriction to physical activity; Older adults with visual, hearing, vertiginous syndrome non-corrected impairment impairment or another limitation that prejudices locomotion; Older adults with another neuropsychiatric condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8dxp8m	Effect of Arginine-containing toothpaste on mineral gain and bioquimic and microbian composition of the dental plaque formed in situ	Data analysis completed	Intervention	2020-03-30	<NULL>	<NULL>	3685	Effect of Arginine-containing dentifrice on remineralization and bioquimic and microbian composition of the biofilm formed in situ	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-04-03	Faculdade de Odontologia da UFRGS	Faculdade de Odontologia da UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-8dxp8m	<NULL>	undergradueted and gratueted students in Dentistry at UFRGS;both genders; a favorable systemic health condition; not having used antibiotics in the 2 months preceding the study.	have an unfavorable systemic health condition; have used antibiotics during the 2 months preceding the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-8d5gwq	Evaluation of the use of the Partial Wrapping of the Premature Body by a Sheet to perform Respiratory Physiotherapy	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3687	Effect of Modified Wrapping on Respiratory Physiotherapy Techniques in Premature - an intervention proposal	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-8d5gwq	<NULL>	The following inclusion criteria were considered: male and female preterm infants, gestational age of up to 37 weeks (&lt;259 days), postnatal age greater than 72 hours of life, weight ?2,500 grams, and medical prescription to perform chest physiotherapy with the need for nasotracheal/endotracheal aspiration.	"The following exclusion criteria were considered: infants under sedative effect, preterm infants with congenital malformations and/or external devices preventing modified swaddling, presence of convulsive seizures, use of surfactant, therapeutic hypothermia, and blood transfusion or any other conditions that presented contraindication for chest physiotherapy by the medical team.
In this study, discontinuity occurred for participants who freed from the swaddle during the intervention or who were transferred to another ventilatory assistance device during the study follow-up period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-6343y7	Effect of different types of physical exercise on cardiovascular risk factors in obese adolescents	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3691	Effect of high intensity interval training (HIIT) and aerobic training on cardiovascular and genetic risk in obese adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-16	Universidade Federal do Paraná	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-6343y7	<NULL>	Individuals of both sexes, aged between 10 and 17 years; Did not present any contraindication to the tests, including absence of cardiac, pulmonary and osteoarticular diseases that compromised muscular strength tests; Do not present contagious diseases of skin (chills, dermatitis, mycoses) that indicate the practice of activities in water; Not to perform other regular physical activity in the last six months, except school physical education (120 min / week); Not participating in any weight loss program; Do not use any medication that interferes with the results of the research.	Obese children and adolescents with infectious-contagious or dermatological diseases that impede participation in the group of aquatic physical exercises; Present musculoskeletal problems or physical disability that would make it impossible to participate in physical activities; Not participate in the second physical evaluation of the project; Participation in at least 75% of classes for exercise groups.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-7bvg7p	Effect of stretching duration for lumbar muscles on electrical activity and stability of multifidus and lumbar iliocostal muscles	Data analysis completed	Intervention	2020-03-31	<NULL>	<NULL>	3692	Acute effect of stretching the paravertebral muscles, and their maintenance time, on a myoelectric activity of the multifunctional and iliocostal lumbar muscles, and on the static skills and statistics of the lumbopelvic region	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade Estadual do Oeste do Paraná - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-7bvg7p	<NULL>	Volunteers with no history of spinal or lower limb disorders, whether acute or chronic, in the last 12 months; and who did not practice physical activity regularly and systematically for at least twice a week	Volunteers with a history of abdominal, hip and spine surgery, regardless of the time taken; pregnant women; that made use of muscle relaxants; that did not meet the entire collection schedule; or EMG signals with poor record quality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-66vrz8	Treatment of patients with severe periodontal disease by common periodontal cleaning or with surgery using an ultrasound device	Data analysis completed	Intervention	2020-04-03	<NULL>	<NULL>	3702	Surgical and non-surgical treatment of periodontitis with ultrasonic debridement: a controlled randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Federal de Goiás	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-66vrz8	<NULL>	Patients with diagnostic of chronic periodontitis, by presence of periodontal pockets with clinical attachment loss of 5 mm, with bleeding on probing, radiographic evidence of bilateral intrabony defect limited to two or three walls determined by periapical radiographs, and the absence of a medical condition that could affect the progression of periodontal disease.	Pregnant or lactating; smokers; Patients who required antibiotic premedication; patients who received antibiotic treatment in the previous 6 months; patients who received a course of periodontal treatment within the past 6 months; tooth with furcation involvements; tooth with endodontic treatment and non-vital tooth; tooth presenting mobility and/or traumatic occlusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-6h8xfn	Effects of grape juice consumption on muscle damage and pain in volleyball athletes	Data analysis completed	Intervention	2020-04-07	<NULL>	<NULL>	3712	Effects of grape juice consumption on oxidative stress and muscle fatigue in volleyball athletes: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-30	Centro Universitário Metodista IPA	Centro Universitário Metodista	https://ensaiosclinicos.gov.br/rg/RBR-6h8xfn	<NULL>	Starting players; male; aged between 14 and 20 years; have daily training routines.	Injured athletes who are out of training and / or competing in the past six months, athletes using anti-inflammatory drugs, and athletes who have an aversion or allergy to the components of grape juice will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-68mmbp	Pain relief strategies at the insertion of Mirena in young women	Data analysis completed	Intervention	2020-04-08	<NULL>	<NULL>	3719	Pain relief strategies at the insertion of the levonorgestrel releasing intrauterine system in young women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade de Medicina-Universidade Federal de Minas Gerais	Faculdade de Medicina-Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-68mmbp	<NULL>	The study included 100 healthy nulligravous women, aged 15-24 years, with indications for use of SIU-LNG (contraception, discontinuation of menstruation, control of menorrhagia, dysmenorrhea, etc.).	The study excluded patients with: hysterometry less than 5 cm; cytological changes in cytology of the last eighteen months; known distortion of the uterine cavity (e.g., by submucosal fibroids); contraindications to the use of progestins; recent history of pelvic inflammatory disease or untreated genitourinary tract infection; abnormal uterine bleeding of unknown cause; less than 6 weeks postpartum or postabortion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-67hbwn	Regular application of Fluoride Gel in the treatment of Incipient Carious Lesions	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	3723	Regular application of Fluoride Gel in the treatment of Incipient Carious Lesions: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Universidade Federal de Santa Maria/ Pró-Reitoria de Pós-Graduação	Universidade Federal de Santa Maria- UFSM	https://ensaiosclinicos.gov.br/rg/RBR-67hbwn	<NULL>	Healthy schoolchildren; age between 6 and 18 years, both genders; presence of at least one non-cavitated active lesion on any surface of any permanent tooth.	Students with fixed orthodontic appliances; schoolchildren with special needs; schoolchildren with cognitive difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4hyp7w	Comparison of respiratory, hemodynamic and metabolic effects between two surgical techniques for the treatment of excessive sweating	Data analysis completed	Intervention	2020-04-09	<NULL>	<NULL>	3726	Respiratory, hemodynamic and metabolic effects during thoracic sympathectomy comparing the surgical techniques apneic and carbon dioxide insufflation	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de SAão Paulo	Hospital Estadual de Diadema	https://ensaiosclinicos.gov.br/rg/RBR-4hyp7w	<NULL>	"Age between 18 and 40 years.
ASA 1 and 2.
Ability to understand the scales for assessing pain intensity and performing spirometry."	"Previous respiratory diseases (both obstructive and restrictive).
History of upper airway infection in the last 2 months prior to surgery.
Smoking.
Severe heart disease (NYHA class III or IV, acute coronary syndrome or tachyarrhythmias).
Insulin-dependent diabetes mellitus.
Obese morbid.
Use of illicit drugs.
Pregnancy.
Previous lung surgery.
Mechanical ventilation in the last 30 days.
Contraindication for total intravenous anesthesia.
Refusal of the patient to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-4v6h7b	Effect of different types of physical exercise on cardiometabolic factors in overweight adolescents	Data analysis completed	Intervention	2020-04-09	<NULL>	<NULL>	3732	Effect of aerobic training and high intensity interval training (HIIT) on cardiometabolic factors in overweight adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Prefeitura Municipal de Curitiba	Friends of the Clinical Hospital	https://ensaiosclinicos.gov.br/rg/RBR-4v6h7b	<NULL>	Overweight adolescents; of both sexes; aged between 10 and 17 years; stable weight over a period greater than or equal to 2 months; height greater than 1.45 m, depending on the height of the bicycle seat; not using anorectic drugs or others that could interfere with weight control and controlled hyperinsulinemia and hypothyroidism; be regularly enrolled in school; present the Free and Informed Consent Form signed by the parents or guardians	Present musculoskeletal problems or physical disability that would make it impossible to participate in physical activities; not participating in the second physical evaluation of the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-7w4cp9	Effectiveness of Osteopathy in Patients with Knee Pain	Data analysis completed	Intervention	2018-09-17	<NULL>	<NULL>	3733	Effects of Osteopathic Manipulative Treatment on Patellofemoral Pain Syndrome of Runners Athletes: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Ceilândia	Faculdade de Ceilândia	https://ensaiosclinicos.gov.br/rg/RBR-7w4cp9	<NULL>	Athlete practicing running; between 18 and 35 years.	Cognitive, musculoskeletal or psychiatric disorders; uncontrolled diabetes mellitus; history of recent infection (last 03 months); use of corticosteroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-946wmb	Effects of osteopathy on pulmonary function in healthy	Data analysis completed	Intervention	2018-09-03	<NULL>	<NULL>	3734	Effects of Osteopathic Manipulative Treatment on the cardiovascular and respiratory systems of healthy youngsters	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Fundação Universidade de Brasilia	Fundação Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-946wmb	<NULL>	Healthy subjects; adults; male	Previous respiratory disease; ribcage deformity; respiratory infection in the past three months; caffeine previous evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-6r7w8k	Study of the cost effectiveness of flour of passion fruit and turmeric on Diabetes	Data analysis completed	Intervention	2020-04-13	<NULL>	<NULL>	3736	Analysis of the effectiveness and cost-effectiveness of two interventions for the glycemic and lipemic control of people with Diabetes: intervention with the Flour of the Passion Fruit Peel and with the Turmeric	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-26	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6r7w8k	<NULL>	patients diagnosed with type 2 diabetes for at least one year; patients aged 18 years or older	patients using insulin; patients using medications such as glucocorticoids, psychotropic or antineoplastic agents; pregnant patients; patients with some type of immunosuppression; patients with complications of type 2 diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-23mbf7	Effects of detraining on the quality of life of elderly people practicing resistance training in water compared to traditional water aerobics training	Data analysis completed	Intervention	2020-04-13	<NULL>	<NULL>	3741	Effects of detraining on the quality of life of elderly people practicing resistance training in water	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23mbf7	<NULL>	"ge equal or superior to 60 years;
Do not present psychiatric and / or neurological disorder (apparent or diagnosed);
Be able to practice physical activity, proven by a medical certificate brought by the patient; have participated in the hydro gymnastics program in the last six months."	the elderly who were unable to visually recognize digits; were affected by any disabling illness that did not allow them to be physically active; having been injured during the program; have been absent from the Hydrogynas program for more than 5 consecutive days; and been participating in any other regular physical activity program in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-7kfwfv	Disinfection efficacy of diode laser in root canal retreatment: a clinical trial with follow up	Data analysis completed	Intervention	2020-04-14	<NULL>	<NULL>	3747	Antimicrobial efficacy of 980 nm diode laser in root canal indicated to retreatment: a randomized trial with clinical and radiographic follow up	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7kfwfv	<NULL>	unirradicular tooth with periapical lesion 2 years; healthy patients	Patients with fractured teeth; perforation; root resorption; pregnant women and have received antimicrobial treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-8mgdwm	Study of the effect of local Infiltration in comparison with intramuscular Infiltration in the treatment of Trigger finger	Data analysis completed	Intervention	2020-04-16	<NULL>	<NULL>	3749	&quot;Local versus systemic infiltration for the treatment of trigger finger: randomized clinical trial - PHASE 3 study&quot;	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-04-12	Hospital Alvorada Moema	Hospital Alvorada Moema	https://ensaiosclinicos.gov.br/rg/RBR-8mgdwm	<NULL>	"Patients over 18 years of age, with trigger finger grade II and grade III of the Green Classification will be submitted to clinical evaluation, in which we will consider three criteria for diagnosis:

Clinical history: pain at A1 pulley level, history of bounce and / or active or passive block, exacerbation of symptoms in the morning;

Physical examination: presence of pain in pulley A1, with or without shoulder or block;

USG: presence of tenosynovitis, with or without tendon nodule. The presence of two of the three criteria will be sufficient for diagnosis and inclusion. There will be no intervention by researchers with regard to the inclusion of patients, with the aim of controlling potential inclusion bias.
After reading, explaining the study proposal and accepting to participate, all research subjects will sign a Free and Informed Consent Form (ICF)"	"Anterior surgical treatment of trigger finger;
Hypersensitivity to the corticosteroid;
Refusal of the consent term"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-6g8n92	Evaluation of the effects of Respiratory Training in patients with Sickle Cell Disease	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3757	Evaluation of the effects of Inspiratory Muscle Training in patients Sickle Cell Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-03	Hemocentro - Universidade Estadual de Campinas	Hemocentro - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6g8n92	<NULL>	Have a diagnosis of sickle cell disease; of both genders; be between 18 and 70 years old; present a stable clinical condition of the disease.	Present neurological or traumatic sequelae that make it impossible to properly perform any of the assessment items; presenting neurological or traumatic sequelae that make it impossible to properly perform inspiratory muscle training; present any lung disease that is not related to sickle cell disease and that may alter the appropriate performance of any of the assessment items.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-52twgg	Effect of caffeine supplementation on physical performance and oxidative stress during high-intensity exercises	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3767	Effect of caffeine supplementation at physical performance and balance redox during a high-intensity interval training (HIIT) protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-20	Universidade Federal do Paraná	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-52twgg	<NULL>	Recreationally active adults; practicing strength training at least 150 minutes a week; male	Habitual caffeine users; individuals not used to strength training; be participating in another study during the analyzes; present an injury or physical impairment that prevented the tests from being performed; cardiovascular diseases; smoker; use of other supplements during testing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-2mht7h	Use of two chemical aids in the treatment of Chronic Periodontitis	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3768	Comparative evaluation of two chemical gel adjuvants in the treatment of Chronic periodontitis: chlorhexidine 1% x melaleuca 2.5%, a double blind randomized controlled clinical study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Centro de Estudos Superiores de Maceió	Centro de Estudos Superiores de Maceió	https://ensaiosclinicos.gov.br/rg/RBR-2mht7h	<NULL>	The sample consisted of systemically healthy patients; age range 18 to 60 years old; diagnosed with chronic periodontal disease.	The exclusion criteria consisted of patients presenting   any negatively tissue healing pathology (eg diabetes mellitus); pregnant and breastfeeding women; participants who were allergic to the study adjuvants; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-4hb9qs	"Efficacy of Auriculotherapy in treatment of chronic pain caused by
Chikungunya"	Data analysis completed	Intervention	2020-04-22	<NULL>	<NULL>	3769	"Efficacy of Auriculotherapy in Analgesia of chronic pain caused by
Chikungunya: randomized controlled clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4hb9qs	<NULL>	have a clinical and / or laboratory diagnosis of chikungunya; having been in pain for at least three months; be aged between 18 and 80 years; having preserved cognitive functions	"having a previous cancer diagnosis;
being on immunosuppressive drugs; have been hospitalized up to 30 days before the start of auriculotherapy sessions"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9ybbch	Effects of Manual Techniques versus an Exercise Program on Low Back Pain in Karate Fighters: experimental study	Data analysis completed	Intervention	2019-10-10	<NULL>	<NULL>	3770	Effects of Manual Therapy versus an Exercises Program on Low Back Pain in karate fighters: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	centro universitário unieuro	centro universitário unieuro	https://ensaiosclinicos.gov.br/rg/RBR-9ybbch	<NULL>	Individuals that presented with acute lower back pain; Karate practitioner for at least six months; That they agreed not to undergo any physiotherapeutic treatment or other rehabilitation procedure during the study period; Individuals who did not change their physical exercise habits during the study period.	"They had degenerative pathologies; Cardiovascular diseases,
Metabolic diseases; History of musculoskeletal injury in a period of six months prior to the survey; Cognitive deficit or non-collaborative patient; Illiterate or had difficulty understanding; Missed two consecutive appointments."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-952kfh	Evaluation of two  plastic bags to prevent admission hypothermia in preterm babies less than 34 weeks of gestational age	Data analysis completed	Intervention	2018-07-24	<NULL>	<NULL>	3777	Evaluation of two  polyethylene plastic bags to prevent admission hypothermia in preterm babies less than 34 weeks of gestational age	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-18	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-952kfh	<NULL>	Preterm inborn infants; with less than 34 weeks of gestational age; both gender.	No measurement of temperature at hospital admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-35szqq	Use of biological glue in the surgery of retained third molars	Data analysis completed	Intervention	2020-04-29	<NULL>	<NULL>	3779	Comparison of mucosal healing with the use of suture and biological glue in retained third molar surgery: a pilot project	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-26	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-35szqq	<NULL>	Healthy volunteers; both genders; age between 18 and 40 years; presence of two retained lower third molars.	Volunteers with systemic diseases that alter bone metabolism; diabetes mellitus; uncontrolled heart disease; blood clotting problems; healing problems; undergoing chemotherapy or radiation therapy; immunodepressed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-57yqwb	Effects of Intermittent Fasting and Low Calorie Diet on health parameters and body weight	Data analysis completed	Intervention	2020-04-29	<NULL>	<NULL>	3789	Metabolics effects and body composition of individuals submitted to Intermittent Fasting or Continuous Caloric Restriction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-57yqwb	<NULL>	"Be training regularly under professional supervision;
Be aged between 18 and 40 years;
Have a BMI equal to or greater than 24.99 kg / m2;
Agree to perform biochemical tests on your own"	subjects with kidney diseases; hormonal diseases and limiting joint diseases; heart disease and diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-5746z9	Impact of photobiomodulation in the salivary flow of patients treated with radiotherapy and chemotherapy for head and neck cancer: double blind and randomized  pilot study.	Data analysis completed	Intervention	2020-05-04	<NULL>	<NULL>	3799	Impact of photobiomodulation in the salivary flow of patients treated with radiotherapy and chemotherapy for head and neck cancer: double blind and randomized  pilot study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-23	Próprio pesquisador	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5746z9	<NULL>	Patients with cancer of the head and neck (oral cavity, pharynx, larynx and occult primary) with indication of treatment with radiotherapy; Patients that the irradiation field must include all major salivary glands.	"Patients younger than 18 years or incapacitated to answer questions; Initial tumors (T1 and T2) and limited to the larynx, other sites such as metastases and skin tumors; Indication of RT with palliative intent; Patients with Diabetes Melitus, autoimmune, infectious and collagen diseases.
Patients who use drugs that may interfere with the salivary flow; Patients with trismus or limitation of mouth opening due to surgical sequelae."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4t8q6z	Influence of genetic variants on health-related assessments and on the effect of Physical Training on the elderly	Data analysis completed	Intervention	2018-02-20	<NULL>	<NULL>	3801	Influence of genetic polymorphisms in physical fitness, functional capacity, incidence of falls and response to Physical Training in elderly	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-11	Escola de Educação Física e Esporte de Ribeirão Preto	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4t8q6z	<NULL>	Men and women with different levels of physical activity and aged between 50 and 80 years.	To present some medical, mental or musculoskeletal conditions that could prevent the performance of the motor tests and the physical training program; presenting a body mass index greater than 35 kg/m2, resting systolic blood pressure greater than 160 mmHg and resting diastolic blood pressure greater than 100 mmHg; have a frequency of less than 75% in the activities proposed by the intervention (in this case, it would not carry out the reassessment; only initial data used in the cross-sectional analysis).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4m6yr2	Evaluation of sensitivity after home bleaching by applying bleaching gel with and without desensitizing agent	Data analysis completed	Intervention	2017-03-28	<NULL>	<NULL>	3805	Evaluation of dental bleaching sensitivity at home applying bleaching gel with and without desensitizing agent - randomized, triple blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4m6yr2	<NULL>	Patients with good general health will be included in this study; Age between 18-50 years of age; Good oral hygiene; Absence of caries in the anterior and inferior teeth; Absence of palatal and vestibular restorations; Upper canine with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients who have undergone previous bleaching procedures will be excluded; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-83cd7j	Evaluation of dental sensitivity  after restoration in posterior teeth applying a dentin wet adhesive vs. dry	Data analysis completed	Intervention	2017-06-27	<NULL>	<NULL>	3806	Evaluation of post-operative sensitivity in posterior restorations with an adhesive system applied on moist vs. Dry dentin: a double-blind, randomized, clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-83cd7j	<NULL>	Patients with good general health will be included in this study; Age: between 18-50 years of age; Good oral hygiene; Present at least 20 teeth under occlusion; At least two carious lesions and / or indication of replacement restoration (fracture, secondary caries, temporary restoration), one in each hemiarco with a minimum depth of 3 mm.	Patients with extremely poor oral hygiene will be excluded; Severe or chronic periodontitis; Severe bruxism; Parafunctional habits; Continuous use of medication that may alter the perception of pain (analgesic, anti-inflammatory); Patient undergoing bleaching treatment; pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4tkys8	Evaluation of dental office bleaching sensitivity with bleaching gel with and without desensitizing agent	Data analysis completed	Intervention	2017-01-18	<NULL>	<NULL>	3809	Evaluation of tooth sensitivity after in office dental bleaching applying whitening gel with and without desensitizing agent - randomized clinical trial, triple blind	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4tkys8	<NULL>	Patients with good general health will be included; Age between 18-50 years of age; Good oral hygiene; Absence of caries in the anterior and inferior teeth; Absence of palatal and vestibular restorations; Upper canine with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients will be excluded: undergoing previous bleaching procedures; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-69d7cz	Evaluation of dental sensitivity after restoration in posterior teeth by applying a conventional adhesive with damp dentin. dry	Data analysis completed	Intervention	2018-05-04	<NULL>	<NULL>	3814	Evaluation of postoperative sensitivity in further restrictions applying a conventional adhesive in dentina ummida vs. dry: randomized, double-blind clinical test	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-69d7cz	<NULL>	Patients with good general health; Age: between 18-50 years of age; Good oral hygiene; Present at least 20 teeth under occlusion; At least two carious lesions and / or indication of replacement restoration (fracture, secondary caries, temporary restoration), one in each hemiarco with a minimum depth of 3 mm.	Hygiene will be excluded; Severe or chronic periodontitis; Severe bruxism; Parafunctional habits; Continuous use of medication that may alter the perception of pain (analgesic, anti-inflammatory); Patient undergoing bleaching treatment; pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-9jd7b7	Effects of the intensity of Interval Training on aerobic fitness, body composition and resting metabolic rate of women with Overweight or Obesity: a randomized controlled trial	Data analysis completed	Intervention	2020-05-06	<NULL>	<NULL>	3815	Effectiveness of two different Training approaches in body composition (cc) and cardiorespiratory resistance (rc) in an interdisciplinary program for adults with Overweight or Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Centro Universitário de Maringá	Centro Universitário de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-9jd7b7	<NULL>	Volunteer women; aged between 18 to 45 years; sedentary; body mass index equal or greater than 25 kg/m2; stable body weight in last three month.	Comorbidities or pathologies associated, except those of metabolic syndromes; use of medications and/or supplements to weight-loss; performing a restrictive diet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-44ys9m	Vocal training with tongue vibration exercise in women	Data analysis completed	Intervention	2020-05-08	<NULL>	<NULL>	3823	Periodized Vocal Training with sound tongue trills technique in women with vocal complaints: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-44ys9m	<NULL>	age between 18 and 45 years; without laryngeal lesions found by ENT examination; vocal or laryngeal complaints after using the voice	participants who were unable to perform the tongue vibration technique; who had a clinical history of neurological, endocrine, metabolic, syndromic and or psychiatric diseases; allergic and / or respiratory crises or hormonal changes; pregnancy; smokers; history of laryngeal and / or pulmonary surgery, who underwent speech and / or otorhinolaryngological treatment due to vocal problems; hearing complaints	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4jm343	Effect of Physical Exercise on blood levels of fat and Inflammation of young women using Contraceptives	Data analysis completed	Intervention	2019-12-11	<NULL>	<NULL>	3831	Effect of Physical Exercise on the lipid and inflammatory profiles of young women in continuous Oral Contraceptive use	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-10	Grupo Nobre de Ensino Ltda.	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-4jm343	<NULL>	Sedentary women; nulliparous; continued use of combined oral contraceptives for 6 months or more, aged 20 to 30 years.	Hepatic Impairment; diabetes; thyroid dysfunctions; kidney diseases; use of anabolics; alcoholism; smoking; corticoids; use of lipid lowering agents; diuretics; beta-blockers; obesity; polycystic ovary syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-282s2f	Sucess of endodontic treatment in baby teeth using Feapex paste in babies from 1 to 3 years old	Data analysis completed	Intervention	2020-05-14	<NULL>	<NULL>	3833	Effectiveness of pulpectomy in primary molars with Feapex paste containing calcium hydroxide and iodoform: prospective clinical study in babies from 1 to 3 years old	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Faculdade de Odontologia da Universidade de São Paulo	Fundação Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-282s2f	<NULL>	Only children aged 1 year to 3 years and 11 months of age; who presented with primary teeth diagnosed with pulp necrosis or with irreversible pulpitis were included; who completed at least 6 months of clinical and radiographic follow-up were included in the analyses.	The exclusion criteria were as children with systemic and/or neurological diseases; teeth that had dental anomalies, periapical cyst, advanced internal / external resorption (more than 1/3 of the root length), involvement of the permanent successor crypt and presence of less than 2/3 of the root formed in the radiographic examination 21, and teeth that could not be appropriately isolated with rubber dam.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-2spcx5	Evaluation of the bone formation in the midpalatal suture after low level laser irradiation	Data analysis completed	Intervention	2020-05-19	<NULL>	<NULL>	3846	“In vivo evaluation of the osteoinductive action of low-power laser on bone formation of the median palatal suture after rapid maxillary expansion	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-04-25	School of Dentistry of Ribeirão Preto	School of Dentistry of Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2spcx5	<NULL>	Age between 6 to 12 years old; both genders; patients in mixed dentition; skeletal maxillary hypoplasia; crossbite greater than 4 mm; intermolar distance smaller than 31mm; upper first permanent molars fully erupted	Patients with dark pigmentation on the palate region; patients with systemic abnormalities; patients with special needs; presence fo dental malformations; patients with high risk for dental caries; high dental caries activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-3jx5n7	Analysis of the Mobility of patients hospitalized in the ICU submitted to Physiotherapy in relation to Perme Escore	Data analysis completed	Intervention	2018-06-18	<NULL>	<NULL>	3849	Analysis of the Mobility of critical patients submitted to Physiotherapeutic Intervention in relation to Perme Escore	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3jx5n7	<NULL>	Patients hospitalized in the adult ICU of the HC-UFU; older than 18 years; with MRC (muscle strength rating scale) between 36 and 48 points; hemodynamically stable.	Patients younger than 18 years; hemodynamically unstable; without muscular weakness acquired in the ICU; MRC greater than 48 points.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-8mgc3h	Motivational Interview and text messaging post-discharge for support for smoking quit	Data analysis completed	Intervention	2019-03-11	<NULL>	<NULL>	3850	Motivational Interview and text messaging post-discharge for supporting tobacco use cessation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-29	Universidade Federal de Juiz de Fora	HOSPITAL UNIVERSITÁRIO - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-8mgc3h	<NULL>	Aged 18 years or older. Smoked cigarettes in the last 30 days (even a puff). Have own mobile phone. Have received at least one text message in the last year. Have no problem with the mobile phone signal.	Don’t have a mobile phone. Unstable cognitive or physical condition. Physical or breath contact restrictions. Intensive care units.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-5t399r	Single visit x multiple visit endodontic treatment: success after 1 year of treatment	Data analysis completed	Intervention	2018-03-27	<NULL>	<NULL>	3860	"Quantification of endotoxins and its relation with signs and symptoms: single  X
multiple-visits - one year follow-up by CBCT analysis"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-08	ICT Instituto de Ciência e Tecnologia - Unesp de São José dos Campos	FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5t399r	<NULL>	Unirradicular teeth with presence of pulp necrosis and periapical lesion and absence of previous endodontic treatment were included in the study in patients with favorable health conditions.	The authors excluded teeth with periodontal disease, root fracture, exposure of the pulp chamber, patients who used antifungals and antibiotics in the period of three months before the endodontic treatment, impossibility of absolute isolation and paper points insertion in the root canal  working length.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-7wx8fy	Evaluation of the use of Laser Therapy on the decrease of microorganisms on dental plaque	Data analysis completed	Intervention	2020-05-22	<NULL>	<NULL>	3865	"Use of Photodynamic Therapy in the Microbiological Remission of Supragingival
Biofilms adhered to dental surface"	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-02	Faculdade de Odontologia de Ribeirão Preto/Universidade de São Paulo - FORP/USP	Faculdade de Odontologia de Ribeirão Preto/Universidade de São Paulo - FORP/USP	https://ensaiosclinicos.gov.br/rg/RBR-7wx8fy	<NULL>	Healthy volunteers; both genders; non smokers; age 10 to 40 years old; presence of dental plaque on dental surface	Were excluded volunteers diagnosed with any systemic diseases; syndromes; pregnant and lactating women; or who made usage of medicines that alter the salivary flow	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-5kyg2r	Effectiveness of Betamethasone versus Triamcinolone injection in the treatment of Alopecia	Data analysis completed	Intervention	2020-05-25	<NULL>	<NULL>	3868	Effectiveness of intralesional Betametasone versus Triancinolone Acetonide in the treatment of Alopecia Areata	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-24	Universidade Federal do Ceará, Campus Sobral	Universidade Federal do Ceará, Campus Sobral	https://ensaiosclinicos.gov.br/rg/RBR-5kyg2r	<NULL>	both genders; age between 18 and 60 years; clinical diagnosis of localized alopecia areata, with less than 25% area of hair loss; presence of an alopecia patch with a larger diameter between 2 and 5 cm	any form of therapy for alopecia areata in the past 3 months; use of systemic corticosteroids or immunosuppressive drugs; illness or condition that causes immunosuppression; rapidly progressive disease; presence of another cause of alopecia; presence of an inflammatory process in the alopecia patch; history of allergy to corticosteroids; pregnancy or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-94pj2d	Effectiveness of computed tomography in face fracture diagnosis	Data analysis completed	Intervention	2020-05-25	<NULL>	<NULL>	3870	Effectiveness of computed tomography with three-dimensional reconstruction in the diagnosis of panfacial fractures	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-94pj2d	<NULL>	Suspected fractures of the middle third of the face requiring computed tomography for diagnostic purposes.	Patients referred with CT already performed in another hospital and patients with a past history of facial fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-2s29md	Effects of Non-Invasive Ventilation During Sleep in Patients with Chronic Obstructive Pulmonary Disease (COPD)	Data analysis completed	Observational	2020-05-25	<NULL>	<NULL>	3872	Acute effects of Noninvasive Ventilation on sleep physiology in patients with stable moderate to severe Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2s29md	<NULL>	Adult patients; over 40 years old; diagnosed with COPD by spirometric criteria, classified as moderate or severe; with stable disease characterized by the absence of exacerbation for more than 2 months; with absence of other pulmonary, cardiovascular, renal and neurological morbidities; and who signed the informed consent form	Patients who did not complete the study protocol; and who did not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-6mjqrf	Evaluation of chloroquine blood levels.	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3879	A comparative bioavailability study of two formulations of chloroquine in healthy volunteers	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2017-05-08	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6mjqrf	<NULL>	"Men,
Non-pregnant and non-breastfeeding women
Within the age range 18 to 50 years old
Body Mass index range 19 to 28,5 Kg/m2
Health volunteers
Signed Informed Consent"	"hypersensitivity to the drug (clhoroquine): Previous pathologies that could influence the absorption distribution or excretion of the drug; Positive G6PD deficiency quantitative or pregnancy test.  Use o concomitant medicines; Any clinical or laboratory exam abnormality;
Smokers; heavy coffee drinkers (&gt;5 cups/Day); Abusive alcohol use: use of any treatment within 2 weeks before the study;Any previous hospitalization with 8 weeks before the study: Any previous treatment with known drug interaction with the test drug within 03 months; Blood donation greater than 450ml 03 months prior the study, or 1500ml in the previous 12 months; Use of Cyp 450 Inductors medications 4 weeks prior; Consume of alcohol or grapefruit 48h prior hospitalization;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-563rmd	Effect of therapeutic laser on lip performance	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3881	Effect of low-level laser therapy on the performance of the orbicularis oris muscle	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-563rmd	<NULL>	Age between 18 and 35 years; sign the Informed Consent Form	use of myorelaxing and/or anti-inflammatory drugs; photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the application site; history of cancer; use of a pacemaker or other electronic implant; having undergone previous orofacial myology therapy; presence of a beard or mustache at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-6xfzht	Nutritional Assistance Study in Overweight Elderly submitted to Bodybuilding Training	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3882	Randomized Nutritional Intervention Study in Overweight Elderly submitted to Strength Training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6xfzht	<NULL>	Volunteers of both genders; age greater than or equal to 60 years; overweight (Body Mass Index greater than or equal to 25kg / m²) classified according to the world health organization or waist circumference (WC) classified as high risk for women (WC greater than or equal to 80cm) and men (WC greater than or equal to 94cm ); absence of mental or psychological illnesses; without physical limitations.	Age less than 60 years; absence of excess weight (Body Mass Index less than or equal to 25kg / m²) classified according to the world health organization or waist circumference without the presence of high risk for women (WC greater than or equal to 80cm) and men (WC greater than or equal to 94cm); mental or psychological illnesses; people with physical limitations; refusal to the informed consent term.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-7xx7g7	Evaluation of the effect of therapies to support facial disorders on physical, psychological, social and sleep-related aspects	Data analysis completed	Intervention	2020-03-30	<NULL>	<NULL>	3887	Evaluation of the effect of support therapies for Temporomandibular Disorders (TMD) about physical, psychosocial and related to sleep	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2018-12-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7xx7g7	<NULL>	Patients with a positive diagnosis for TMD obtained through axis I of the RDC / TMD were included; those who underwent last treatment for TMD with a minimum interval of 3 (three) months; individuals with reports of pain in the orofacial region in the last 3 (three) months; patients aged 18 to 65 years.	Individuals with impaired cognitive ability who were unable to understand the questions in the questionnaires were excluded; those with a history of head trauma that is related to the etiology of orofacial pain and that can confuse the diagnosis of TMD; those with headaches or intracranial disorders; individuals who have used medications in the past 3 months that interfere with sleep quality such as muscle relaxants, anticonvulsants, antidepressants and anxiolytics; patients using medication to treat TMD or muscle pain; those who had other causes of orofacial pain such as caries, periodontal diseases, neuropathies and fibromyalgia; who had an insurmountable fear of a needle or bleeding disorders (only for the craniopuncture group).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-4wt3h7	Comparative evaluation of two motivational methods performed during Periodontal Treatment in patients with Gingival Disease	Data analysis completed	Intervention	2020-05-28	<NULL>	<NULL>	3888	"Comparative evaluation of two motivation programs carried out during Therapy
Basic Periodontal disease in patients with Gingival and Periodontal Disease"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Centro de Estudos Superiores de Maceió	Centro de Estudos Superiores de Maceió	https://ensaiosclinicos.gov.br/rg/RBR-4wt3h7	<NULL>	"Systemically healthy patients; patients over 18 years of age and under 65
years; patients able to read and sign the IC; patients diagnosed with periodontal disease and in need of basic periodontal therapy; patients who have access to an instant messaging application (WhatsApp)."	"Patients with any pathology
that negatively influences tissue healing (eg diabetes melitus); patients using any drugs that negatively influence the oral environment; pregnant and nursing patients; patients with chronic renal failure; patients with advanced liver disease (eg, cirrhosis); patients with decompensated hypertension or an increased risk of cardiovascular disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-8tkmr7	Fluoride soluble in artificial gastric juice as an indicator of systemic bioavailability of toothpastes	Data analysis completed	Intervention	2020-06-01	<NULL>	<NULL>	3890	Fluoride soluble in HCl 0.01 N found in  MFP/CaCO3 - based toothpaste as indicator of fluoride systemically bioavailable	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-8tkmr7	<NULL>	participants in good general health; participants with normal salivary flow (unstimulated saliva equal to or greater than 0.3 to 0.4 mL per min)	participants with kidney disease; participants with gastrointestinal disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-4xktdc	Effect of Ondansetron on thermal pain levels (heat and cold), mechanical and pain control mechanisms in humans	Data analysis completed	Intervention	2020-03-27	<NULL>	<NULL>	3893	Effect of Ondansetron on the threshold of thermal and mechanical pain and conditioned modulation of pain in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4xktdc	<NULL>	Healthy individuals of both sexes, aged between 18 and 60 years, with classification of physical status by the American Society of Anesthesiologists - ASA I, were invited to participate in the project.	Individuals with chronic pain, defined as pain lasting more than 3 months, of any origin were not included. as well as those who used analgesics, antidepressants, benzodiazepines or any drug with psychoactive action in the last 14 days prior to the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-63c3gn	Histomorphometric and immunohistochemical evaluation of beta-tricalcium phosphate of different particles dimensions in maxillary sinus floor elevation: a randomized clinical study	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3898	Prospective, randomized clinical study for bone repair after grafting on human maxillary sinuses	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-63c3gn	<NULL>	Atrophic posterior maxillary region and residual bone height less than 5 mm requiring bone augmentation rehabilition with dental implants.	smokers, patients with uncontrolled systematic disease, maxillary sinus diseases, and patients with an inadequate amount of bone in the mandible symphysis where the autogenous bone graft was harvested.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-4pjmbb	Therapeutic Ultrasound associated with the application of copaiba and tea tree oil in the treatment of leg ulcers: a controlled and randomized clinical study	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3899	Low Frequency Ultrasound associated to application of Copaíba and Melaleuca Oil in process of healing of Venous Ulcers: Controlled and Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4pjmbb	<NULL>	"Individuals over 18 years of age;
To present venous ulcer;
To attend the outpatient clinic on pre-established days, for at least 10 days after the start of the intervention;
To present glycemic control, without the use of anti-inflammatory medication by any route of absorption."	"Present necrotic tissue with indication of limb amputation;
Under treatment by radiotherapy;
Wounds due to radiotherapy; Pregnant patients;
Patients with metallic implants in the region; Diagnosis of deep venous thrombosis; Hemophiliac patients or those at risk of hemorrhage;
Smoking patients; Patients on corticosteroids; Diabetic patients;
Use unna&apos;s boot as a treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-39srtp	Effects of vitamin D3 supplementation on oxidative and inflammatory stress markers in overweight or obese workers	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3905	Effects of vitamin D3 supplementation on inflammation and oxidative stress markers in overweight and obese women: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-39srtp	<NULL>	women aged between 18 and 59 years; have vitamin D deficiency or insufficiency; have a Body Mass index greater than 25 kg / m²; do not take any vitamin D supplementation; not taking anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; not having a diagnosis of Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; do not drink alcoholic beverages; do not smoke	Women with previous vitamin D use; women under 18 or over 59; women using anticonvulsants or medications to treat the human immunodeficiency virus or acquired immunodeficiency syndrome; women diagnosed with Type I Diabetes Mellitus, nephrotic syndrome, acute or chronic kidney disease, liver disease, hypothyroidism, hyperthyroidism, history of stroke or acute myocardial infarction in the last 6 months; Alcoholic women; smoking women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-76c257	Effects of different physical activity programs on women&apos;s health	Data analysis completed	Intervention	2020-06-03	<NULL>	<NULL>	3906	Effects of Long-Term Physical Activity Programs on Physical Capacity, Body Composition and Symptoms of Anxiety and Depression in Women	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-76c257	<NULL>	Being female; age between 18 years and 80 years; body mass index (BMI) greater than or equal to 25 kg / M2; use the public health service.	against medical indications to perform physical activity with moderate and vigorous intensity; have a cardiac pacemaker; pregnant women; already carry out physical activity programs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-88jff9	Evaluation of the prediction of soft tissues of the face with computed tomography of dental and bone deformities before and after surgery of retracted jaws	Data analysis completed	Intervention	2020-06-04	<NULL>	<NULL>	3912	Uncontrolled experimental study: pre and postoperative tissue evaluation, using computed tomography, of a series of cases with class II Dentoeskeletal deformity, surgically treated	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Instituto de Gestão Estratégica de Saúde do Distrito Federal	Instituto de Gestão Estratégica de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-88jff9	<NULL>	The present study included 16 clinically healthy patients, all classified as Angle class II, in whom control CT scans had been obtained at an interval of 6 to 72 months after surgery. All cases had undergone prior orthodontic preparation with a view to orthognathic surgery	Patients with syndromic dentofacial deformities; asymmetries;  postoperative follow-up of less than 6 months were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4j5g96	Characterization of the patient with painful click in the jaw joint.	Data analysis completed	Observational	2020-06-15	<NULL>	<NULL>	3921	Clinical, somatosensory and psychosocial characterization of patients with painful temporomandibular joint clicking: a cross-section study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	FACULDADE DE ODONTLOGIA DE BAURU	FACULDADE DE ODONTLOGIA DE BAURU	https://ensaiosclinicos.gov.br/rg/RBR-4j5g96	<NULL>	Volunteers with complaints of clicking and pain or just clicking on the temporomandibular joint; both genders; age between 18 and 70 years.	Volunteers with different clicking noises; individuals with complaints of non-articular pain; patients with a known diagnosis of degenerative joint diseases; patients who had undergone previous surgery of the temporomandibular joint; individuals under the influence of analgesic, anti-inflammatory, antidepressant, anticonvulsant and benzodiazepine medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-8q8c6n	Effect of laser on individuals with tinnitus.	Data analysis completed	Intervention	2020-06-15	<NULL>	<NULL>	3922	The use of low-level laser in patients with tinnitus and without hearing loss	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-18	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-8q8c6n	<NULL>	Consent to the Informed Consent Form. Normal bilateral audiometry with ISO mean up to 25dB. Complaint of continuous tinnitus for at least six months. Age 18 years or older.	Performing another treatment for tinnitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3jv46h	Effects of beta-alanine supplementation in muscle strength and mass.	Data analysis completed	Intervention	2020-06-19	<NULL>	<NULL>	3928	Effects of beta-alanine supplementation in neuromuscular parameters of resistance-trained young men.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3jv46h	<NULL>	individuals should have a minimum experience of 6 months with the regular practice of strength training; training frequency greater than or equal to three weekly sessions.	Those who might have clinical limitations that could compromise their health and safety would be excluded. Those who practice other types of strength training would also be excluded. During the period, the volunteer who was injured, regardless of the reason, or if he was absent from more than three consecutive training sessions, would be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-6xq95s	The Effectiveness of Associated Non-Pharmacological Measures in the prevention and redution the duration of Delirium subtypes in ICU patients	Data analysis completed	Intervention	2018-10-03	<NULL>	<NULL>	3931	The Effectiveness of Combined Non-Pharmacological Interventions in the prevention and redution the duration of Delirium subtypes in critically ill patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-14	Universidade do Estado da Bahia	Hospital Santa Izabel	https://ensaiosclinicos.gov.br/rg/RBR-6xq95s	<NULL>	Participants will be those over 18 years of age, with an expected length of stay in these units over 48 hours, who score in the E-PRE-DELIRIC score greater than or equal to 10% and who voluntarily agree to participate in the study	Patients who: are admitted to delirium; admitted to these ICUs, but who had had delirium in the previous hospitalization; are admitted in contact and / or respiratory precaution; receptive aphasia; Have severe hearing and / or visual disturbances that prevent adequate communication; To present psychiatric disorders, in acute phase, that cause cognitive alterations, like attention deficit and / or hallucinations; They are unable to understand Portuguese; Present scores on the Richmond Agitation-Sedation Scale (RASS) less than or equal to -3	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-7nqsm5	Visual Characteristics of Cholesterol Plaques in Patients with Myocardial Infarction: Contemporary Optical Coherence Tomography Findings	Data analysis completed	Observational	2020-06-22	<NULL>	<NULL>	3932	Morphology and Phenotype Characteristics of Atherosclerotic Plaque in Patients with Acute Coronary Syndrome: Contemporary Optical Coherence Tomography Findings	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-7nqsm5	<NULL>	Patients with Acute Coronary Syndrome;Optical Coherence Tomography pre-stent	Cases with poor image quality;imaging artifacts;in-stent restenosis;images from non-culprit lesions;pós-stent images.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-3fryp7	"Analgesic efficacy of codeine phosphate in combination with paracetamol after
wisdom tooth extractions"	Data analysis completed	Intervention	2020-06-22	<NULL>	<NULL>	3936	"Analgesic efficacy of codeine phosphate in combination with paracetamol after
extractions of impacted lower third molars"	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2013-11-11	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3fryp7	<NULL>	Age between 18 and 50 years; both sexes; no systemic disease or locoregional changes that may affect the tissue repair process or in post-operative sensitivity.	Contraindications of dexamethasone, paracetamol, codeine phosphate and mepivacaine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4cwps2	Effects of electrostimulation in patients with chronic pain from HIV	Data analysis completed	Intervention	2020-06-23	<NULL>	<NULL>	3938	Effects of Interferential Current upon HIV neuropathic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-02	Universidade La Salle	Universidade La Salle	https://ensaiosclinicos.gov.br/rg/RBR-4cwps2	<NULL>	Women with HIV/AIDS; aged between 18 and 65 years; in antiretroviral therapy; have neuropathic cervicalgia, confirmed by LANSS scale.	Active contagious infection (meningitis, pulmonary tuberculosis); history of chronic diseases associated with neuropathic pain (diabetes, lupus, rheumatoid arthritis, infection by Human T-cell Lymphotropic Virus); chronic renal or peripheral vascular insufficiency; oncologic disease; severe disease that limits the understanding of the informed consent or tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-5c3tb9	Bacterial adherence to silk and nylon suture	Data analysis completed	Intervention	2020-06-24	<NULL>	<NULL>	3948	"Efficacy of antiseptic ointment in preventing of
bacterial contamination on suture"	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-04-03	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5c3tb9	<NULL>	Moth genders. Older than 18 years. With indication of extractions of minimum of two teeth in both hemiarchs of the same dental arch.	Patients with systemic diseases. Patientes with  local changes sugestinf infecction. Patients allergic to the components of the ointment. Patients with reports of antimicrobial use in the last 15 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-5xbwjk	Transcranial stimulation applied to fibromyalgia	Data analysis completed	Intervention	2020-06-24	<NULL>	<NULL>	3949	Neuromodulation applied to fibromyalgia (neurofibro): double-blind, controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5xbwjk	<NULL>	Having a diagnosis of fibromyalgia, according to the criteria of the American College of Rheumatology; having been diagnosed at least three months ago; be female; be in the age group between 27 and 58 years old; and signing the Informed Consent Form.	Score below 24 on the Mini Mental State Examination; metal implants located on the head; cochlear implants and cardiac pacemaker; illiterate; pregnant women; history of seizure; and severe depression with a score greater than 35 in the Beck Depression Inventory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-7t6ycp	Physical Exercises Compared to Guidelines in Patients with Jaw Joint Dysfunction	Data analysis completed	Intervention	2020-06-26	<NULL>	<NULL>	3959	Physical Exercises X Orientations in Patients with Temporomandibular Joint Displacement: Randomized controlled blinded clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7t6ycp	<NULL>	Volunteers over the age of 18, with disc displacement with reduction, who sought the TMD clinic at the Federal University of Vales do Jequitinhonha and Mucuri and who agreed to participate in the study by signing the Free and Informed Consent Form Informed Consent Form.	Edentulous participants, patients who have previously been treated for TMD treatment and patients with systemic diseases that could cause joint and / or muscle changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-4pphkf	Effectiveness of prayer in chronic kidney patients	Data analysis completed	Intervention	2020-06-30	<NULL>	<NULL>	3964	Effectiveness of prayer on chronic kidney disease patients on hemodialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4pphkf	<NULL>	Age over 18 years, literate, clinically stable and oriented about time and space when reaching 24 or more points in the Mini Mental State Exam.	Presence of deafness, as it was decided to apply the prayer with the aid of headphones; present limitations that compromised speech; and who have used anxiolytics within 24 hours prior to the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-537s3c	Sensory analysis of functional cooking recipes designed for students from 09 to 15 years from Campinas / SP	Data analysis completed	Observational	2020-07-01	<NULL>	<NULL>	3967	Evaluation of the acceptance of healthy recipes developed for students between 09 and 15 years of Campinas / SP	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-09-17	Rosana Gomes Arruda Leite Bueno	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-537s3c	<NULL>	Be a student enrolled in a municipal school; have between 9 and 15 years old.	Not having signed the consent or agreement term; have sensitivities, allergies or intolerance to any of the ingredients used in the preparations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-9xmfyq	"Botulinum Toxin type A for the treatment of 
smile with gum exposure"	Data analysis completed	Intervention	2020-07-01	<NULL>	<NULL>	3968	Evaluation of different doses of botulinum toxin type A for the treatment of gingival smile	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-08	Centro Brasileiro de Estudos em Dermatologia	Centro Brasileiro de Estudos em Dermatologia	https://ensaiosclinicos.gov.br/rg/RBR-9xmfyq	<NULL>	"Individuals aged between 18 and 70 years;
Superior anterior gingival exposure: more than 4 mm, for subjects included in group A and 2 to 4 mm, for subjects included in group B;
Presence of at least one indication for cosmetic treatment with botulinum toxin in the upper face;
Medical history and physical examination that, in the opinion of the investigator, does not interfere with the progress of the study;
Women of childbearing potential should have a negative urinary pregnancy test at visit 1. These subjects should use a highly effective contraception method during the study: combined oral contraceptives [estrogen and progesterone] or implanted contraceptives (with a stable dose for at least 1 month prior to study entry), bilateral tubal ligation, hormonal intrauterine device (inserted at least 1 month prior to study entry), strict abstinence (at least 1 month prior to entry into the study and agree to continue for the duration of the study), or vasectomized partner (at least 3 months prior to study entry) or use of condom;
Women presenting for childbearing potential (e.g. before menstruation, post menopause (absence of menstrual bleeding for 1 year before entry into the study), hysterectomy, or bilateral ovariectomy, less than one year postmenopausal);
Willingness to comply with protocol requirements and study duration.
Understanding and signing the Informed Consent Term (ICF) at baseline, before any study procedure is performed."	"Pregnant and/or breastfeeding women, or women who wish to become pregnant during the study period;
Any surgical intervention that has affected the area evaluated in this study;
Any cosmetic procedures, including fillers, or scars that may interfere with the results of the study;
Previous treatment with botulinum toxin for gingival smile less than 6 months ago, or for other indications on the face less than 12 months ago;
Evident facial asymmetry;
Active inflammation or infections in the treated areas;
Neoplastic, muscle or neurological diseases (e.g. Myasthenia Gravis, Lambert-Eaton Myasthenic Syndrome and motor neuron disease);
Serious psychiatric disorders;
Any other disease or chronic or serious decompensated medical condition that, in the opinion of the investigator, may interfere with the assessments or participation in the study or put subject at significant risk;
History of sensitivity to the formula components;
Current use of aminoglycoside antibiotics or penicillamines, quinines or calcium channel blockers or use at any time during the study;
Coagulation disorders or use of anticoagulants; 
Vulnerable subjects (such as those deprived of their liberty) as defined in Section 1.61 of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) for Good Clinical Practice (GCP);
Subjects with history of non-adherence to medications or showing difficulties to adhere to the study protocol;
Current participation in another drug or device clinical study OR participation within 30 days prior to Day 1 OR in a period of exclusion from a previous clinical study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-888t7r	Comparation between Elixir Sanative® and Chlorexidine mouthwash in cicatrization after tooth extractions	Data analysis completed	Intervention	2020-07-02	<NULL>	<NULL>	3970	Comparative study of Elixir Sanative® and Chlorexidine in alveolar cicatrization	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-888t7r	<NULL>	healthy patients; with an indication for tooth extraction contralateral without the requirement for osteotomy or odontosection.	"patients with pathologies
systemic diseases; smokers; alcoholics;pregnant women; patients allergic to one or more drugs used and patients who used anti-inflammatory
or antibiotic in the last 07 days."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-3h5394	Walking program for elderly women with high blood pressure	Data analysis completed	Intervention	2018-11-06	<NULL>	<NULL>	3971	Walking program for elderly hypertensive women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-05	Hospital Universitario Onofre Lopes	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3h5394	<NULL>	Age between 60 and 75 years; women; body mass index lower than 35 kg/m2; physically inactive; previous diagnosis of hypertension; absence of any other cardiometabolic disorder or disease; no severe musculoskeletal problem that limits walking practice; signed consent form; medical clearing after physical exercise test	Change in medication during the study period; withdrawal the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-86ksrj	Effects of Aromatherapy on labor: A triple blind randomized clinical trial	Data analysis completed	Intervention	2020-07-03	<NULL>	<NULL>	3973	The use of aromatherapy in humanized labor	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2018-12-05	universidade federal do piaui	universidade federal do piaui	https://ensaiosclinicos.gov.br/rg/RBR-86ksrj	<NULL>	Pregnant women in active labor; of age; term pregnancy; In spontaneous labor; live fetus, fetus with cephalic apex presentation, fetus with good vitality conditions.	Pregnant women in latent labor; pregnant women who had an indication for cesarean delivery at admission; pregnant women who had clinical complications; pregnant women with changes in amniotic fluid and presence of fetal malformation; pregnant women in labor induction or with indication for uterotonic use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-3bt9sb	Ankle range of motion assessment in professional soccer players	Data analysis completed	Observational	2020-07-03	<NULL>	<NULL>	3974	Ankle Test application in the assessment of ankle range of motion in professional soccer players	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	universidade federal de sergipe	universidade federal de sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3bt9sb	<NULL>	SUB-19 football players who are enrolled in the 2019 Sergipe championship	Not being entered in the competition or having an injury on the day of the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-584pt5	The effects of participants&apos; engagement on the efficacy of actions to practice Mindfulness meditation	Data analysis completed	Intervention	2020-07-07	<NULL>	<NULL>	3983	The effects of beneficiary&apos;s engagement on the efficacy of social interventions to practice Mindfulness	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-09	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	Centro de Pós Graduação e Pesquisa em Administração - CEPEAD - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-584pt5	<NULL>	Students regularly enrolled at Federal University of Minas Gerais	Subjects presenting acute episodes of major depression disorder; anxiety disorder; dissociative disorder; schizophrenia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7rmtzg	Effect of lipids associated with toothbrushing regarding teeth color alteration, surface roughness and microhardness - an in vitro and in situ study.	Data analysis completed	Intervention	2019-01-16	<NULL>	<NULL>	3984	Effect of phytosphingosine associated with toothbrushing regarding color alteration, surface roughness and microhardness of dental enamel - an in vitro and in situ study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7rmtzg	<NULL>	Both genders; overall health status; with no oral pathologies; age between 20 and 35 years.	Use of removable prosthesis; use of orthodontic device;fluoride compounds use in the last two months; pregnant women; breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-7k4wgt	Pilates applied to control nonspecific low back pain in university students	Data analysis completed	Intervention	2020-07-08	<NULL>	<NULL>	3985	Influence of a hybrid pilates exercise program in the treatment of chronic non-specific low back pain and quality of life in medical students.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-15	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7k4wgt	<NULL>	Medical school students were included in the study, who had low back pain, who had no history of spine surgery; history of spine fracture; inflammatory, rheumatic or neurological disorders; systemic metabolic disease; nerve root involvement; tumor; infection; osteoporosis; severe structural deformity; who did not undergo any type of physical rehabilitation through exercise in the last 3 months and who did not take pilates classes; who undertake to perform the exercises in person and at home, as established in the project.	Participants who would not participate in the study after signing the informed consent form would be excluded from the study; to develop or worsen the pain process as a result of the exercises; pregnancy; diagnosis of diseases listed in the inclusion criteria, after agreeing to participate, that contraindicated the performance of exercises; that initiated any type of exercise modality in the period destined for the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-4n7j6h	The effect of Bee Honey With and Without Propolis in reducing the occurrence of Respiratory Problems in malnourished children treated at CREN	Data analysis completed	Intervention	2020-07-09	<NULL>	<NULL>	3993	Efficacy of Honey Abelha With and Without Propolis in Respiratory Events in Malnourished Children treated at CREN	<NULL>	2-3, non-randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2010-09-01	Telma Maria de Menezes Toledo Florêncio	Centro de Recuperação e Educação Nutricional - CREN	https://ensaiosclinicos.gov.br/rg/RBR-4n7j6h	<NULL>	Children with primary malnutrition (&lt;-1.5 Z-score stature/age) in monitoring semi-boarding school in the Center for Recovery and Nutrition Education.	Children without malnutrition and 72 months or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-93rvm9	Evaluation of dental extraction technique with minimally traumatic extractor	Data analysis completed	Intervention	2020-07-09	<NULL>	<NULL>	3995	Evaluation of surgical technique with minimally traumatic extractor	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-24	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-93rvm9	<NULL>	The criterion for inclusion of patients in the study was the presentation of at least one residual root or indication of exodontia (teeth severely destroyed to the point of rendering their restoration unfeasible, or by prosthetic indication). These teeth could be of the maxilla or jaw (excepting the molars), that is, incisors, canines and premolars. In addition, the individual should agree to participate in the study by signing the TCLE.	The exclusion criteria consisted basically of patients with some factor that contraindicated the surgical procedure, such as: infection installed at the site; uncontrolled systemic disorders, such as diabetes and hypertension; problems in the coagulation cascade; severe anemia; allergies; patients who used some medicine with interference in bone metabolism; pregnant patients; and patients who used drugs that stimulated gingival augmentation (antihypertensives, anticonvulsants, calcium channel blockers, among others), asthmatic patients without the opinion of the penumatologist and patients who had recently had Chikuncunha.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-28yb2g	Evaluation of postoperative pain from TMJ surgery and dexamethasone infiltration	Data analysis completed	Intervention	2020-05-27	<NULL>	<NULL>	3998	"Evaluation of postoperative pain in patients undergoing joint arthroscopy
mandibular temporalis with infiltration of dexamethasone disodium phosphate in
different isolates"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-10	Sociedade Beneficente de Senhoras Hospital Sírio-Libanês	Sociedade Beneficente de Senhoras Hospital Sírio-Libanês	https://ensaiosclinicos.gov.br/rg/RBR-28yb2g	<NULL>	patients needing surgery; arthroscopic TMJ, temporomandibular disorders with Wilkes stages III and IV (Wilkes 1989) caused any of these pathologies: degenerative joint disease; synovitis; painful hypermobility; recurrent dislocation of disc cause; hypomobility caused by intra- articular; inflammatory arthropathies	skin or joint infection tumors ankylosis diabetic neuropathies; fibromyalgia and / or neuromuscular diseases; multiple sclerosis; also patients allergic to dexamethasone; unilateral TMJ surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-23sqxz	Impact of cream vaginal use on complications in women using vaginal ring  in treatment of genital prolapse: a randomized clinical trial	Data analysis completed	Intervention	2018-08-24	<NULL>	<NULL>	4009	Impact of estrogen use on complications in women using vaginal pessaries with genital prolapse: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-25	Uiversidade Estadual de Campinas (Unicamp)	Uiversidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-23sqxz	<NULL>	Women with genital prolapse; Stage two, three and four prolap; to be using vaginal pessary	"hormone dependent neoplasms;
Not accepting to participate in the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-7g48v7	respiratory muscle training in healthy subjects	Data analysis completed	Intervention	2020-07-17	<NULL>	<NULL>	4016	Respiratory muscle strength in healthy university	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-18	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-7g48v7	<NULL>	"Are within the age limit ( 18 to 30 ) ;
Not present chronic or acute diseases ;
Who accept participate in the study after signing the Informed Consent and Informed ( WIC)."	"Individuals under 18 and / or greater than 30 years old ;
show any acute or chronic disease;
Do not agree to participate in the collection;
Individuals who fail to answer the research instruments ;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-4mtyr5	Comparison between two different materials for making aesthetic orthodontic bandages in terms of color stability and elastic properties	Data analysis completed	Intervention	2020-07-21	<NULL>	<NULL>	4025	"Aesthetic orthodontic bandages: evaluation of elastic properties and alteration of
color"	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP/USP)	Faculdade de Odontologia de Ribeirão Preto - Universidade de São Paulo (FORP/USP)	https://ensaiosclinicos.gov.br/rg/RBR-4mtyr5	<NULL>	Patients with complete permanent dentition (except third molars); between 12 to 20 years old, undergoing orthodontic treatment; good general and oral health; who have not used mouthwash and systemic medication in the last 3 months.	Patients in the transitory phase of dentition, still with the presence of deciduous teeth, presenting poor oral hygiene and consequent oral health, patients with systemic problems and who have used mouthwash and systemic medication for continuous use in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-7tmpdb	Nutritional and Metabolic Profile of Adolescents with Obesity who will undergo Counseling Sessions on Behaviors related to Changes in Lifestyle	Data analysis completed	Intervention	2020-07-22	<NULL>	<NULL>	4028	Nutritional and Metabolic Profile of Adolescents with Obesity submitted to a Behavioral Counseling Program: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-26	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tmpdb	<NULL>	Adolescents; both sexes; age between 13 and 18 years; obese	Body mass above 120 kg; Positive PAR-Q; self-reported diseases; electrocardiographic changes at rest; chronic alcohol consumption; previous drug use; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-4jbw4s	Use of Botulinum Toxin for Treatment of Idiopathic Rhinitis	Data analysis completed	Intervention	2020-07-23	<NULL>	<NULL>	4033	Use of Botulinum Toxin Type A for Treatment of Idiopathic Rhinitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4jbw4s	<NULL>	Criteria for inclusion in the study: Patients older than 18 years who signed the informed consent form and understood the explanation of the study, carried out by the researcher himself. Patients of both sexes, without distinction of race. Patients diagnosed for idiopathic rhinitis for at least one year, ie patients in whom the other etiologies of rhinitis (allergic rhinitis, non-allergic, drug, hormonal, drug and occupational eosinophilic rhinitis) were excluded from the clinical history , physical examination, nasal cytology examination with eosinophils below 2%, and immediate hypersensitivity skin test for negative inhalants.	Exclusion criteria in the study: Patients with other nasal anatomical abnormalities, such as nasosinusal polyposis or obstructive nasal septum deviation. Patients with acute or chronic rhinosinusitis. Patients with severe systemic diseases, glaucoma or prostatic hypertrophy that may be aggravated by anticholinergic therapy. Patients with immediate hypersensitivity skin test for positive inhalants, nasal cytological examination with eosinophilia greater than 2%.Patients who received rhinitis medications prior to the immediate inhalant hypersensitivity skin test. Patients pregnant or likely to be pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-8s56by	Effect of musical stimulation associated with Physiotherapy on the movement of sedentary elderly	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4039	Effect of Rhythmic Auditory Stimulation associated with Physiotherapy on the functional mobility of sedentary elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-04	Camila Maria Mendes Nascimento	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8s56by	<NULL>	"Patients aged 60 years or older; sedentary;
with the ability to move independently; lack of medical contraindications for physical exercise; ability to understand instructions and active participation in tasks, considering the scores of the Mini Mental State Examination (MMSE) corresponding to their schooling; visual acuity confirming through the Snellen Signal Scale; hearing acuity verified through the whisper test"	Patients with neurological diseases; orthopedic, rheumatic and  or vascular pathology, with moderate or severe functional restriction in one or both lower limbs;history of fracture in the last year; hypertension and or uncontrolled heart disease; limiting visual and or auditory compromises for the execution of the protocol; amputee, prosthesis and lower limb orthosis users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-5s8fy4	Evaluation of the effects of Occlusal Splints and Hypnosis in the treatment of bruxism: A randomized controlled trial	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4041	Electromyography and analysis of quality of life in patients with Bruxism before and after treatment with Occlusal Splints, Hypnosis and Restoration of Canine Guidance - randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-05	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-5s8fy4	<NULL>	elderly patients, presenting reports of waking up with muscle fatigue and / or pain in the TMJ area, with tooth wear and / or edentulous line in the cheek mucosa, reports of noise (teeth grinding) at night evidenced by a partner, being orthognathic, without missing teeth and as few restorations as possible, from a pre-existing database	underage patients, with dental problems with occlusal instability, prognosis and compensation, alcohol, patients with removable prostheses, large amounts of indirect restorations, use of bite plates, neurological or psychiatric disorders, who use drugs that act on the central nervous system, as antidepressant inhibitors of serotonin reuptake, diseases with muscle and / or motor impairment, cognitive impairments and use of illicit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-32rp22	Effect of therapeutic laser on the lips fatigue	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4045	"Effect of low-level laser on the 
electromyographic fatigue of the orbicularis oris muscle"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Centro Universitário Metodista Izabela Hendrix	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-32rp22	<NULL>	"Age between 18 and 60 years; sign the
Informed Consent Form"	"Craniofacial anomaly or disease with neuromuscular involvement; use of myorelaxing and/or anti-inflammatory drugs; 
photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the
application site; history of cancer; use of a pacemaker or other electronic implant; having undergone previous orofacial myology therapy; presence of a beard or mustache at the time of data collection."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-4wr8mz	Evaluation of the effect of deep water running for the treatment of  back pain	Data analysis completed	Intervention	2020-07-27	<NULL>	<NULL>	4052	Evaluation of the effect of deep water running for the treatment of back pain	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2014-11-27	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4wr8mz	<NULL>	Patients diagnosed with low back pain participated in the study; comprised between the last rib and the gluteal fold; mechanical in character; lasting more than 3 months on most days; with pain assessed by the visual analogue pain scale (VAS) between 3 to 8 cm, and who agreed to participate in the study and signed the free and informed consent form.	"Patients with the following items were excluded from the study:

Fibromyalgia;
Contraindication to the use of non-hormonal anti-inflammatory drugs (NSAIDs)
Pregnancy;
Litigation;
Obesity (BMI&gt; 30);
Secondary causes of low back pain; as spondyloarthropathies; infections; neoplasms; fractures;
Previous spine surgery;
Complete sciatica (irradiated to lower limb below the knee);
Uncontrolled arterial hypertension;
History of coronary insufficiency or history of cardiac revascularization; history of syncopes or arrhythmias induced by physical exercise;
Decompensated diabetes mellitus;
Serious psychiatric illnesses;
History of regular physical exercise (at least 30 minutes twice a week) in the last 3 months;
Hip and / or knee arthroplasty; and any other condition that makes it impossible for the patient to walk and
Dermatological diseases that contraindicate the use of a swimming pool."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5j2w34	Use of the walking diary after Cardiac Surgery	Data analysis completed	Intervention	2020-07-28	<NULL>	<NULL>	4059	Walking diary in the Cardiac Rehabilitation Phase 1	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-31	Hospital Santa Izabel	Hospital Santa Izabel	https://ensaiosclinicos.gov.br/rg/RBR-5j2w34	<NULL>	Individuals in pre operative of elective cardiac surgery of myocardial revascularization and / or valve surgery; with age equal to or greater than 18 years; of both sexes.	Those with difficulty understanding the procedures performed in the research; that present motor impairment that makes it impossible to perform gait without assistance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-7k79kd	Effect of betaine supplementation on the athlete&apos;s ability to perform multiple repetitions on the bench press	Data analysis completed	Intervention	2020-07-28	<NULL>	<NULL>	4062	Effect of betaine supplementation on athletes&apos; physical capacity	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-12-27	CAPES	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7k79kd	<NULL>	Men; Healthy; age between 18 and 30 years; strength training practitioners; no history of use of nutritional supplementation; no history of injury.	Perform training sessions 24 hours before the experimental protocol, present with late-onset muscle pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-78dh5d	Comparison between skin closure with single and intradermal points on the knee prosthesis	Data analysis completed	Intervention	2020-07-29	<NULL>	<NULL>	4065	Comparative analysis between single and intradermal skin cloruse in total knee arthroplasty	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Hospital Universitario Ciencias Medicas	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-78dh5d	<NULL>	Patients with primary or secondary gonarthrosis; with indication of total knee arthroplasty; aged 45 to 85 years; both sexes.	Patients with a previous history of knee surgery; with inflammatory diseases of the joints; smokers, i.e. at least 1 cigarette a day; alcoholics with consumption equal to or greater than 15 doses per week for men and 10 doses per week for women; with hypoalbuminemia, i.e. albumin level below 3.5 mg per dl and anemia with hemoglobin less than 10 mg per dl.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5bzbvs	Analysis of 2 drug protocol of dexamethasone in the removal of wisdom tooth	Data analysis completed	Intervention	2020-07-30	<NULL>	<NULL>	4072	Analysis of 2 preemptive periods of dexamethasone in the removal of the third molars. A controlled, randomized, split-mouth, and triple-blind clinical study	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Estudal Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5bzbvs	<NULL>	Young adult patient (18-30 years); Third bilateral molars (upper and lower) with similar positions and angulations evaluated in panoramic; Need for osteotomy and odontostomy for exodontia.	Smolker; Decompensated Metabolic Diseases; Use of medicines that interfere with healing; Periodontal Disease; Inflammation or pathologies associated with third molars.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-76r3t7	Effect of Vocal Therapy associated with Electrical Stimulation in women with Voice Changes	Data analysis completed	Intervention	2020-08-03	<NULL>	<NULL>	4078	Effect of Electrostimulation associated with Semi-occluded Vocal Tract Exercises in patients with Behavioral Dysphonia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-76r3t7	<NULL>	Women; aged 18 to 60; behavioral dysphonia	Patients with organic changes of congenital origin; diagnosis of head and neck cancer; history of previous surgery in the head and neck region with impact on the voice; patients with neurological diseases; history of speech therapy in the last six months; history of electrical stimulation in the last six months; thyroid changes; severe heart disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-544pfq	Telephone Monitoring of Blood Cancer Patients in outpatient Chemotherapy: proposal for an assistance protocol	Data analysis completed	Intervention	2020-08-05	<NULL>	<NULL>	4086	Telephone monitoring of onco-hematological patients undergoing outpatient chemotherapy: proposal for an assistance protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Universidade Federal Fluminense	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-544pfq	<NULL>	Medical diagnosis of Lymphoma that would initiate first-line outpatient chemotherapy treatment regimen: International Disease Code (ICD-10) for Non-Hodgkin&apos;s Lymphoma and its classifications (C82 to C85) and Hodgkin&apos;s Lymphoma and its classifications (C81), absence of previous chemotherapy treatment and who had Karnofsky Perfomance Status (KPS) or Zubrod Scale (ECOG) between 70% to 100% or 0-1 (Appendix A) (90-1), respectively, assessed by the doctor and the nurse at the first consultation turn; patients aged 18 to 64 years and have a fixed or mobile phone.	Presence of cognitive deficit and / or change in physical conditions that make participation in the research and hearing deficit unfeasible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-8j2r7d	Study on Resisted Exercise in improving Fatigue in Patients with Primary Sjogren&apos;s Syndrome: Blind Randomized Clinical Trial	Data analysis completed	Intervention	2020-08-05	<NULL>	<NULL>	4087	Effectiveness of Resisted Exercise in improving Fatigue in Patients with Primary Sjogren&apos;s Syndrome: Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8j2r7d	<NULL>	"Be diagnosed with Sjogren&apos;s syndrome according 
the American-European Consensus criteria, having fatigue complaint, age above 18 years, woman."	Patients with cognitive difficulties, secondary Sjogren&apos;s Syndrome; regular physical activity practitioner or who had been practicing physical activity regularly for up to 8 weeks prior to initiation of the protocol; patients who did not accept the study norms; those with clinical conditions that precluded the practice of exercise program according to previous medical evaluation( such as decompensated diabetes mellitus, decompensated thyroid diseases, cardiorespiratory diseases); systemic diseases such as renal failure, liver failure, anemia and muscle inflammation; use of hypnotic or immunotherapeutic medications such as rituximab; age below 18 years or above 100 years;  men	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-8mqt4m	Effects of a multi-component training program on physical fitness and risk of falls in the elderly	Data analysis completed	Intervention	2020-08-05	<NULL>	<NULL>	4089	Effects of a multilateral training program on pjysical fitness and parameters related to the risk of falls in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-21	Universidade Federal do Paraná	Gleber Pereira	https://ensaiosclinicos.gov.br/rg/RBR-8mqt4m	<NULL>	Older adults; both genders; able to perform standardized exercises; present a medical certificate proving that they are clinically able to perform physical exercises; accept to participate voluntarily by signing a free and informed consent form	Older adults who participated in less than 70% of sessions; older adults who had some type of injury severe in the last six months prior to the study, which prevented them from performing all scheduled exercises and assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-6jmwc8	Meditation effect on blood pressure of adults with high blood pressure	Data analysis completed	Intervention	2020-08-06	<NULL>	<NULL>	4091	Meditation acute effect on hypertensive adults blood pressure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal do Estado de São Paulo	Universidade Federal do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6jmwc8	<NULL>	Hypertensive adults aged between 30 to 50 years of age	Absence in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-4vynk5	Effect of the Increase of daily steps in Urinary symptoms and Cardiac function in men aged 50 to 59 years	Data analysis completed	Intervention	2020-08-07	<NULL>	<NULL>	4099	Effect of the Increase of daily steps in Lower urinary tract symptoms, Autonomic cardiac function and Maximum oxygen consupmtion in men aged 50 to 59 years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-27	Hospital Universitàrio da Faculdade de Medicina da Universidade Federal de Juiz de Fora	Hospital Universitàrio da Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4vynk5	<NULL>	men, aged 50 to 59 years, complain of lower urinary tract symptoms with a result greater than or equal to eight in the application of the International Prostate Symptom Score instrument	Tobacco use, conditions that make physical exercise unfeasible, chronic or prostatic diseases, previous history of bladder or prostatic surgery, neurological dysfunction of the bladder, bladder neck or urethral stenosis, as well as lithiasis, carcinoma or bladder polyposis, recurrent UTI, concomitant use or in the month prior to inclusion of any drug or condition affecting urinary function, cardiological and neurological diseases and use of any drug or substance that had action in the autonomic nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-35mxys	Lack of a chiral pharmacokinetic interaction between venlafaxine and nifedipine in healthy subjects phenotyped as normal CYP2D6, CYP2C19 and CYP3A metabolizers.	Data analysis completed	Intervention	2020-08-07	<NULL>	<NULL>	4102	Lack of a chiral pharmacokinetic interaction between venlafaxine and nifedipine in healthy subjects phenotyped as normal CYP2D6, CYP2C19 and CYP3A metabolizers.	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2010-01-30	CAPES	CNPQ	https://ensaiosclinicos.gov.br/rg/RBR-35mxys	<NULL>	Healthy volunteers; male; adults (23-33 years old); self-reported as white, body mass index (BMI) of less than 25 kg/m2; biochemical and hematological parameters within healthy range;	Smoking volunteers; volunteer using drugs; volunteers with biochemical and hematological parameters registered abnormality;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-6h9wqy	The Effect of a Respiratory Physiotherapy Procedure on Microcephaly	Data analysis completed	Intervention	2020-08-11	<NULL>	<NULL>	4107	Impact of a Respiratory Physiotherapy Protocol on Patients with Mirocephaly	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Centro Universitário Braz Cubas	Centro Universitário Braz Cubas	https://ensaiosclinicos.gov.br/rg/RBR-6h9wqy	<NULL>	Confirmed diagnosis of Microcephaly; Both sexes, aged up to six years; Whose parents and / or guardians have signed an informed consent form (ICF); Follow up at Centro Universitário Brazcubas; Patients with at least 75% attendance.	Whose parents and / or guardians have not signed the Free and Informed Consent Form (ICF); Tracheostomized patients and / or dependent on invasive mechanical ventilation; Patients with less than 75% frequency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-5wqr2j	Pain education and exercise program supported by mobile phone for patients with chronic low back pain	Data analysis completed	Intervention	2020-08-13	<NULL>	<NULL>	4129	Pain education and exercise program supported by mobile technology for patients with chronic low back pain: a pilot study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-27	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5wqr2j	<NULL>	Patients with low back pain as their primary musculoskeletal complaint (pain between the 12th thoracic vertebra to the gluteal fold) for three or more months; with or without irradiation of symptoms to lower limbs; aged 18 and over; both sexes; residents of the of Fortaleza, CE.	Patients with severe hearing or cognitive deficits that would prevent them from answering the questionnaires; those who present complaints of pain in the lumbar region with specific diagnosed origin (fracture, tumor, vertebral stenosis); severe associated systemic or neurological disease; history of spine surgery; in physical therapy treatments for DLC or who do not have a cell phone. Those who use medications with analgesic action were not excluded from the project, however the amount and type of medication used were recorded in the pre and post intervention periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-3nqhfy	Quality of life assessment after dental sensitivity treatment with ozone oil	Data analysis completed	Intervention	2020-08-17	<NULL>	<NULL>	4130	Quality of life assessment after dentin hypersensitivity treatment with ozone oil - triple blind randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	UFVJM	UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-3nqhfy	<NULL>	Patients complaining of dentin hypersensitivity with cold, sweets, acidic foods and brushing, and with clinical diagnosis of dentin hypersensitivity; both sexes; without distinction of color or socioeconomic condition; age between 18 to 60 years; with good general and oral health.	Patients presenting restorations and carious lesions in the exposed dentin of hypersensitive teeth; who used painkillers, anti-inflammatories and antidepressants frequently; and, presence of gingival inflammation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-262j28	Endoscopy Removal of Polyps from the Large Intestine and Rectum by the Water Immersion Technique	Data analysis completed	Intervention	2020-08-17	<NULL>	<NULL>	4132	Colorectal Mucosectomy of Adenomas and Serrated Lesions by the Water Immersion Technique (Underwater): A Prospective Clinical Study	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-01-22	Hospital Madre Teresa	Hospital Madre Teresa	https://ensaiosclinicos.gov.br/rg/RBR-262j28	<NULL>	Patients with lesions without endoscopic stigmata of deep submucosal invasion, equal to or greater than 5 mm in length and considered suitable to endoscopic resection. Lesions not previously detected but which were identified during the study&apos;s procedure and fulfilled these criteria were also included.	Exclusion criteria were lesions that showed signs of malignant degeneration or deep submucosal invasion (depression, ulceration, friability, bleeding, induration, Kudo pit pattern V); pedunculated polyps; patients with familial polyposis syndromes; those with contraindications (e.g. coagulation disorders and other comorbidities) for endoscopic resection by any technique and patients who did not agree to participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6tnm7d	Nutritional response and clinical complications in patients with enteral tube	Data analysis completed	Intervention	2020-08-18	<NULL>	<NULL>	4133	Enteral nutritional therapy in hospitalized patients: enteral tube usage in post-pyloric and gastric positions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6tnm7d	<NULL>	Adults hospitalized patients with risk for malnutrition	Patients were excluded when transfered to other hospitals or when another route of diet provision was suggested	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6pf78g	Effect of selfintention practice on eating behaviour, body measures and body image in overweight women	Data analysis completed	Intervention	2020-08-18	<NULL>	<NULL>	4136	The impact of self-intention on food intake, anthropometry and body image of overweight women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-10	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6pf78g	<NULL>	Women with BMI &gt; 25Kg/m²; have access on internet; have smartphone with WhatsApp	Be in treatment for weight loss in the last three months, whether by use of medications or diets; have a BMI of less than 25 kg/m²; being in use of hormone replacement therapy; presenting some physical deficiency that prevents the accomplishment of the anthropometric measures; presenting some level of cognitive deficit that prevents the eating record register	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-58pgs4	The influence of Pain Neuroscience Education associated with Meditation on sleep and functional capacity of adults with Fibromyalgia	Data analysis completed	Intervention	2020-08-19	<NULL>	<NULL>	4140	Influence of Pain Neuroscience Education associated with Meditation on quality of life, sleep and functional capacity of elderly people with Fibromyalgia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-58pgs4	<NULL>	Being 40 years of age or older, having a medical diagnosis of fibromyalgia, with pain intensity classified as moderate or severe by the Numerical Pain Rating Scale, 0 being considered painless, 1 to 3 mild pain, 4 to 6 moderate pain and 6 to 10 severe pain.	Individuals who showed signs of cognitive decline when scoring below the cut-off point in the Mini Mental State Examination (MMSE) were excluded - in the case of elderly participants; have hip or knee limitations, or difficulties in performing movements at ground level; practice physical activity regularly, corresponding to more than 150 minutes of physical activity weekly; have some acute emotional involvement (an event in the last 5 months that leaves you emotionally vulnerable, such as deaths, accidents and other personal and emotional issues); self-reported obsessive compulsive disorder (OCD); being under fibromyalgia treatment or having undergone it in less than 3 months; having more than 25% of absences in the interventions (equivalent to 3.25 absences).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-85yygn	Nutritional assessment of severe pediatric patients using muscle ultrasound	Data analysis completed	Observational	2020-08-20	<NULL>	<NULL>	4146	Nutritional assessment of severe pediatric patients using ultrasonography of the quadriceps femoris	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Tiago Henrique de Souza	Tiago Henrique de Souza	https://ensaiosclinicos.gov.br/rg/RBR-85yygn	<NULL>	Patients between 28 days and 14 years of age admitted to the pediatric intensive care unit.	Patients with a hospital stay of less than 48 hours; patients with neurodegenerative muscle diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-9fb24p	Stretching effects on elderly with high blood pressure	Data analysis completed	Intervention	2020-08-20	<NULL>	<NULL>	4147	Muscle stretching exercise effects on hypertensive elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal do Estado de São Paulo	Universidade Federal do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9fb24p	<NULL>	Hypertensive aged between 60 and 80 years of age	Have chronic obstructive pulmonary disease, limited locomotion and mobility and absence on the sessions over than 25%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-8h6qxv	The warm compress in the care of febrile children: Randomized Clinical Trial.	Data analysis completed	Intervention	2020-08-21	<NULL>	<NULL>	4148	Effectiveness of tepid sponging intervention in reducing temperature of children with fever: a pilot randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-11	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitario da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8h6qxv	<NULL>	"Will be included in the study children from 1 month to 11 years 11 months and 29 days, who meet the following criteria:Present axillary temperature 37.8ºC; Interval between the administration of the antipyretic and the beginning of the treatment application, application of warm compresses, up to 10 minutes; Have permission from parents or guardians and agree to participate in the study.
In addition to these criteria, it will also be allowed to include the same patient within 12 hours of the last inclusion in the study and not be under the effect of antipyretic, it is necessary to have a minimum of 6 hours of the last antipyretic."	Patients with the diagnosis of malignant hyperthermia; neurological dysfunction; patients to undergo a procedure for up to 3 hours after administration of the antipyretic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-84j48n	Fascial manipulation (Stecco method)to reduce orofacial pain, masticatory muscles and TMJ	Data analysis completed	Intervention	2020-08-24	<NULL>	<NULL>	4152	Efficacy of myofascial manipulation - Stecco method - to reduce Orofacial pain and TMD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Florence Mitsue Sekito	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-84j48n	<NULL>	Subjects; of both sexes; aged 18 to 65 years old; presenting muscle and/ or joint disorders associated with temporomandibular disorders. Presence of orofacial pain; and presence of pain in the regions: cervical; cervical-brachial; scapular-humeral; thoracic; musculature of the stomatognathic system; verbal rating scale greater than or equal to 6;  chronic pain lasting more than 4 months; signature of the free and informed consent form  agreeing to become the subject of the research.	Patients with syndromes that could affect the musculoskeletal system in any instance; psychiatric alteration acessed by  BELL axis two; associated fibromyalgia, with previous diagnosis performed by the doctor; associated rheumatological diseases, with prior diagnosis made by the doctor; chemical dependency; neurological disorders and patients with neuropathies; coagulopathies with International Normalized Ratio(INR) index less than two; polytraumatized; edentulous patients without prostheses and / or patients with prostheses without conditions of use; severe arthrosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-72386w	Responsiveness to induced stress in students of the Health Sciences at the University of Brasilia	Data analysis completed	Intervention	2020-08-25	<NULL>	<NULL>	4162	Assessment of physiological responses to induced stress in undergraduate students of the health sciences at the University of Brasilia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-72386w	<NULL>	Healthy volunteers. Both sexes. Undergraduate students of the health sciences at the University of Brasilia Campus of Ceilandia. Age between 18 and 30 years.	Use of controlled medication. Severa arrhythmia. Serious neurological conditions. Use of pacemaker. Allergy to any of the materials used in the experiments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-6rc23h	Effect of violet light on in-office dental bleachings: 12 months follow-up	Data analysis completed	Intervention	2020-08-25	<NULL>	<NULL>	4164	Dental bleaching using violet LED associated or not with 37% carbamide peroxide: a randomized double-blinded clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-21	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-6rc23h	<NULL>	Sign the consent form; availability to attend all sessions; age between 18 and 35 years; good health, controlled blood pressure, and adequate oral hygiene; pulp vitality in the teeth to be bleached (1st PM on one side to 1st PM on the opposite side in the upper and lower arches); color of teeth above A2 on the VITA scale, visually identified.	Smoker; pregnant or lactating; heart problems; history of known reaction to peroxides; individual or family history of neoplasia in the oropharynx region and surroundings; history of diabetes or other systemic diseases, which can interfere with the access of tissues from the oral cavity; need antibiotic therapy before dental prophylaxis; presence of oral pathologies, xerostomia, caries lesions, extensive restorations of composite resin, fractures or splinters in the teeth, gingivitis/periodontitis, bruxism, which in the professional&apos;s opinion may compromise the participant&apos;s health or the results of the study; presence of surface irregularities, tetracycline stain, discoloration due to trauma, fluorosis, hypoplasia, dental implant, prosthesis and/or endodontic treatment in upper or lower anterior teeth, or other parameters that may make it difficult to measure tooth color; have made use of bleaching agents in the office or at home in the last year (does not include toothpaste or bleaching mouthwash); spontaneous tooth sensitivity; intention to put a fixed orthodontic appliance during the bleaching assessment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-99j3h4	Neurosensory Posturotherapy in individuals after Stroke	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4167	Comparison between the effect of the Neurosensory Posturotherapy and Mulligan technique on the quality of life and respiratory function of individuals after a Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Norte do Paraná, UENP	Universidade Estadual do Norte do Paraná, UENP	https://ensaiosclinicos.gov.br/rg/RBR-99j3h4	<NULL>	Volunteers affected by Stroke; both genders; age between 18 and 90 years; hemodynamically stable; members of a conventional physiotherapy program	Undisciplined or uncooperative volunteers; absence of medical clearance for the intervention; ; bone disease with risk of fracture; recent fracture; joint effusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-6bzfrn	Effect of a calming medication on reducing anxiety before wisdom tooth removal	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4170	Effectiveness of sublingual alprazolam in reducing anxiety in impacted third molar surgery - controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Hospital Universitário da Universidade Federal de Sergipe	Hospital Universitário da Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6bzfrn	<NULL>	Patients over 18 years; Systemically healthy patients;Presence of asymptomatic impacted third molars; third molars classified as IIB by Pell and Gregory Classification.	Pregnancy or lactation; History of Allergies to drugs or substances used in this experiment; Patients on therapeutic use of psychiatric drugs; menstrual period women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9sy4bz	Effects of two Heating Protocols on Surface Temperature and Functional Performance in Amateur and Recreational Soccer players.	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4175	Evaluation of the Acute Effects of Two Heating Protocols on Surface Temperature and Functional Performance of Lower Limbs of Amateur and Recreational Soccer players.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-14	Fapemig	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-9sy4bz	<NULL>	Male players; Age between 18 and 30 years; Trainings up to 3 times a week; Participating in championships; Without lower limb dominance restriction; Without restriction of operating position.	"History of kidney problems; Physiotherapy in the last two days; Consume any diuretic or antipyretic and any food supplement: such as creatine that may interfere with water or homeostasis body temperature in the last two weeks;
Smoker; Burns on the skin; With topical treatments creams, ointments or lotions; Pain symptoms in any region of the body; Fever in the last seven days; Sleep disorders; Comply with the criteria for musculoskeletal injuries of the Research and Medical Evaluation Center of the International Football Federation;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-44rxxt	Effect of visceral physiotherapy in patients with low back pain	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4176	Effect of visceral physiotherapy in patients with low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Grupo de Pesquisa em Fisioterapia Avaliativa e Terapêuticas - GPFAT	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-44rxxt	<NULL>	30 individuals with chronic low back pain; regardless of gender; aged between 18 and 50 years; participating in the Clinic	volunteers with depression; anxiety; Brain stroke; Parkinson&apos;s; Alzheimer&apos;s; in addition to menstrual changes such as metrorrhagia; they must not have a history of digestive cancer; appendicitis; peritonitis; polyps; diverticulum; intestinal occlusion and malabsorption syndrome; use of analgesic and contraceptive medication for more than six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-8n8csf	Effect of Mesenchymal stem cells in patients with decompensated cirrhosis	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	4177	Bone marrow mesenchymal stem cells in acute-on-chronic liver failure grades 2 and 3: a phase I-II randomized clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2018-09-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8n8csf	<NULL>	fulfilling ACLF diagnostic criteria and ACLF grade 2 or 3	patient’s or family member’s refusal; (b) hepatocellular carcinoma (HCC); (c) formal contraindicationfor liver transplantation (e.g. advanced heart or pulmonary disease); (d) pregnancy and lactation; (e) previous liver transplantation; (f) HIV co-infection; (g) ACLF grade 1; (h) patients admitted for elective procedures; (i) renal chronic disease requiring dialysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-2mt78b	Interference of Methotrexate Tuberculosis Latent Screening Tests and its relation with the clinical, immunological and inflammatory activity of Psoriasis	Data analysis completed	Intervention	2018-06-05	<NULL>	<NULL>	4186	"Interference of Methotrexate on QuantiFERON TB-Gold in Tuberculosis Screening
Latent and its relation to the clinical, immunological and inflammatory activity of Psoriasis"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2mt78b	<NULL>	Moderate to severe psoriasis; referred by dermatologists with indication of methotrexato use; aged over 18 years; living in the northeast region.	Abscence of BCG vaccination scar; pregnant women; women breastfeeding; previous use of immunosuppressant treatment; Topical use of medication for less than 6 months; lithium use; personal history; signs or symptoms of tuberculosis; chest X-ray compatible with lung disease; previous malignancy; positive serology for HIV, hepatitis B or C; liver enzyme elevation 3-fold above baseline; renal clearance less than 60 ml / min; lymphopenia below 1500 lymphocytes; platelet count below 100,000; or leukopenia below 3500 leukocytes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-53s3rk	Functional and strength training in parkinsonians	Data analysis completed	Intervention	2013-09-05	<NULL>	<NULL>	4189	Influence of functional and strength training on neuromuscular adaptations, functionality quality of life, and intracellular mechanisms associated with the muscle weakness in elderly with parkinson&apos;s disease	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2013-03-01	Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-53s3rk	<NULL>	"All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional.
All patients must present the clinical diagnosis of Parkinson&apos;s disease obtained by a neurologist, to present between 50 and 80 years of age, to present Parkinson&apos;s disease between stages 2 and 3, do not perform regular exercise weights six months before starting the training intervention."	Patients who present symptoms of dementia, depression, joint problems, hypertension and stroke will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-6ft5yb	Risk factors in orthopedic prosthesis surgeries	Data analysis completed	Observational	2020-08-31	<NULL>	<NULL>	4192	Multiresistant gram-negative bacteria infections&apos; risk factors in orthopedic prosthesis surgeries	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Fundação Hospitalar São Francisco de Assis	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6ft5yb	<NULL>	Have more than 18 years old; Have prosthesis of hip or knee joint replacements with primary arthroplasty surgery performed from January 2014 to December 2017 at the Hospital; Evolve from January 2014 to December 2017 with prosthesis infection defined by the following Muscolosketal Infection Society (MIS) criteria; In order to be considered a representative sample, the sample sent for culture should meet the following criteria: Collection of bone fragment or Deep tissue such as muscle tissue and fascia or Periprosthetic tissue or capsule or Aseptically collected synovial fluid; Identification of Gram-negative bacteria: Negative agents are identified by conventional biochemical and metabolic tests carried out in the agreed laboratory and in accordance with international norms.	Be under 18 years; Possessing prosthesis of hip or knee joint replacements with primary arthroplasty surgery performed in another institution; Evolution of infection outside the period from 2014 to 2017.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-5pckyr	Capsaicin supplementation combined with aerobic exercise on food intake in young adults	Data analysis completed	Intervention	2020-07-24	<NULL>	<NULL>	4193	"Influence of acute capsaicin supplementation combined with aerobic exercise
dietary intake of physically active young people"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-19	Fábio Santos Lira	Priscila Almeida Queiroz	https://ensaiosclinicos.gov.br/rg/RBR-5pckyr	<NULL>	Healthy volunteers; male gender; age between 18 to 35 years; eutrophic; physically active; non smokers; stable weight in the last six months; without any types of cardiorespiratory impairments and orthopedic limitations that could compromise the participation of this intervention.	Presence of planned surgeries during the study period; any use of medication or psychoactive substances; use of any type of dietary supplement or use of nutritional strategies such as the use of ergogenics; reluctance to sign the informed consent form; participation in another study; alcohol or drug abuse; frequency below 75% in interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-9nt4gj	Effect of chest compression techniques on the diaphragm of healthy children from zero to two years	Data analysis completed	Intervention	2020-09-01	<NULL>	<NULL>	4198	Effect of different chest compression techniques on the diaphragm in healthy infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-18	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9nt4gj	<NULL>	The study included 22 healthy infants born at term (37 to 41 weeks) of both sexes, with at least 72 hours of life, this time was used respecting the safety criteria recommended by the I Brazilian Recommendation of Respiratory Therapy in Unit Pediatric and Neonatal Intensive Care	Infants born preterm, with congenital syndromes, upper or pulmonary airway malformations and central nervous system malformations, grade III or IV perintraventricular hemorrhage, peripheral nervous system injuries that interfere with the movement of the chest and the maintenance of the chest were excluded. airway opening, progressive neuromuscular disease, severe heart disease, congenital infectious disease, gastroesophageal reflux disease, chest or recent face trauma, respiratory disease with or without secretion up to two weeks prior to evaluation and incessant crying.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4jvybh	Effect of electric and magnetic brain stimulation on physical performance	Data analysis completed	Intervention	2020-09-01	<NULL>	<NULL>	4199	Effect of transcranial direct current stimulation and transcranial magnetic stimulation on physical performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-23	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4jvybh	<NULL>	Aged from 18 to 50 years; take part in physical training with competitive purposes during the last six months; participate in endurance competitions; free from any cardiovascular, musculoskeletal, neurological or psychiatric disease; not taking any medication that could affect the central nervous system (citalopram, amphetamines, L-dopa, sulpiride, pergolide, lorazepam, rivastigmine, flunarizine and carbamazepine); not having contraindications for tDCS (not having metal implanted in the head, pacemaker, medical bumps, seizures, lesions on the scalp or head)	Impossibility to analyze the data due to data loss; injury; voluntary abandonment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-7yspdx	Effect of different low-level laser therapy wavelengths on peripheral blood flow, endothelial function and skeletal muscle fatigue	Data analysis completed	Intervention	2020-08-13	<NULL>	<NULL>	4201	Effect of different low-level laser therapy wavelengths on peripheral blood flow, endothelial function and skeletal muscle fatigue: A randomized crossover trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-08	Centro Universitário Euro-Americano	Centro Universitário Euro-Americano	https://ensaiosclinicos.gov.br/rg/RBR-7yspdx	<NULL>	Healthy young individuals aged 20 - 30 years selected from an existing database in our Extension Program.	History of recent infection (in the past 3 months), use of systemic cortiesteroids (in the last 3 months).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-54d3t3	Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Adjunctive Therapies	Data analysis completed	Intervention	2019-10-20	<NULL>	<NULL>	4204	Effects of Photobiomodulation and Antimicrobial Photodynamic Therapy Associated With Subepithelial Connective Tissue Graft on the Root Coverage of Multiple Gingival Recessions: A Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Odontologia de Bauru-Universidade de São Paulo	Faculdade de Odontologia de Bauru-Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-54d3t3	<NULL>	gingival recession in two or more adjacent teeth (multiple recession type defects); teeth witout root canal treatment; Patients without signals of periodontal disease and with plaque and gingival index in all mouth lesser than 20%; And patients that agree to the free and informed consent terms	Patients with systemic diseases that contraindicate surgical procedures or affect the course of healing; Patients who use medication that interferes with the healing process or who use anticonvulsant, antihypertensive or cyclosporine medications, or who have systemic diseases that pose a risk when performing surgical procedures; Smokers, pregnant women; Patients who have previously undergone periodontal surgery in the area of interest. And patients with orthodontic therapy in progression;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-9h4tp3	The impact on the quality of the ECG exam when performed outside the recommended standards	Data analysis completed	Intervention	2020-07-09	<NULL>	<NULL>	4209	Impact on ECG quality when electrodes are applied to incorrect intercostal spaces	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-26	Instituto Nacional de Cardiologia	Lorena Xavier Rocha Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-9h4tp3	<NULL>	"literate who can read and write; is that
hospitalized at the time of carrying out the research in the specific ward for treatment of coronary diseases of that institution; in pre and post-myocardial revascularization surgery operatives; with medical diagnosis of unstable angina; or acute myocardial infarction."	All patients with abnormalities of cardiac cavities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-3s7g4t	Effect of cupping therapy on pain and function in persistent inespecific low back pain: a randomized controlled trial	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	4210	Effect of cupping therapy on pain and function in persistent inespecific low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3s7g4t	<NULL>	Age between 18 and 59 years old, Present persistent nonspecific low back pain	Pregnant women; Women in the postpartum period; Patients who use anticoagulant; Patients who have donated blood in the last 3 months; Anemia; Red flag patients (vertebral fracture; vertebral tumor; vertebral infection; equine tail syndrome; progressive neurological impairment); Systemic diseases (autoimmune; infectious; vascular insufficiency; renal insufficiency; hepatic insufficiency; neoplasia); Fibromyalgia; Lumbar disc herniation; Symptomatic irradiated pain (positive Laségue test); Anterior spine surgery; People with open and poorly healed wounds; Inflamed skin; Alteration of skin integrity; Open fractures; Previous experience of physical therapy treatment in the last 3 months; People who have had previous wind therapy treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-68xbth	Pulse oximeter evaluation in  the reading of tooth oxygenation	Data analysis completed	Intervention	2020-09-04	<NULL>	<NULL>	4220	Pulse oximeter evaluation in oxygen saturation reading of the dental pulp	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-18	Universidade Federal de Santa Catarina	Programa de Pós-Graduação em Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-68xbth	<NULL>	Healthy volunteers; non smokers; both genders; intact permanent teeth without cavities or restorations; teeth with pulp vitality without internal resorption or calcification; teeth with complete root apex without signs of periodontal or periapical lesions	Smoking patients; patients who suffered external tooth whitening; patients with parafunctional habits; patients with a history of dental trauma; pregnant women; lactating women; patients using orthodontic appliances; patients with previous dental pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-5rb2ps	Effects of intensities of exercise combined on type 2 diabetic women in menopause	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	4228	Effects of exercise intensity on metabolic, respiratory and cardiovascular parameters in type 2 diabetic women - a clinical randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de Lavras	Financiamento Próprio	https://ensaiosclinicos.gov.br/rg/RBR-5rb2ps	<NULL>	Being a carrier of DM2; being in amenorrhea for at least 12 consecutive months; be able to exercise by Par-Q; being sedentary or not engaging in regular physical activity (not practicing a minimum of 150 minutes of physical exercise per week according to WHO criteria).	Use of hormone replacement therapy; smoking; presence of coronary artery disease or debilitating diseases; hysterectomized women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-6wghcx	Comparison of Pilates and Bodybuilding in Physical Fitness and Quality of Life in the Elderly of Brasília-DF	Data analysis completed	Intervention	2020-09-09	<NULL>	<NULL>	4230	Comparative Analysis of the Pilates Method and Resistance Training in Physical Fitness and Quality of Life of Elderly in Brasília-DF	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Centro Universitário Euro Americano	Centro Universitário Euro Americano	https://ensaiosclinicos.gov.br/rg/RBR-6wghcx	<NULL>	Elderly women aged 60 years or more, who had not been exercising regularly for at least 3 months.	Elderly women who practiced physical exercise regularly, who had some orthopedic condition that would disable the practice of the activities and elderly women with uncontrolled chronic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4pyjkq	Patient and ventilator mismatch in Noninvasive Ventilation during sleep in patients with Chronic Obstructive Pulmonary Disease	Data analysis completed	Observational	2020-09-10	<NULL>	<NULL>	4234	Patient ventilator asynchrony in sleep stages during Noninvasive Ventilation in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-05	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4pyjkq	<NULL>	Adult patients; over 40 years old; diagnosed with COPD by spirometric criteria, classified as moderate or severe; with stable disease characterized by the absence of exacerbation for more than 2 months; with absence of other pulmonary, cardiovascular, renal and neurological morbidities; and who signed the informed consent form.	Patients who did not complete the study protocol; and who did not sign the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-3cbjq9	Effectiveness of Photobiomodulation in Sensitivity to tooth Whitening in adults: randomized clinical trial.	Data analysis completed	Intervention	2020-09-10	<NULL>	<NULL>	4237	Laser therapy applied for Sensitivity after tooth Whitening	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-07	Universidade Federal do Amazonas - UFAM	Universidade Federal do Amazonas - UFAM	https://ensaiosclinicos.gov.br/rg/RBR-3cbjq9	<NULL>	At least canines with A2 or darker color and six superior anterior teeth free of restorations on the palatine and vestibular faces, healthy enamel and without pathological, physiological and drug alterations.	Volunteers with systemic diseases (metabolic, heart disease and immunological), oral condition with periodontal diseases. with orthodontic appliance, severe crowding, presence of intrinsic stains, using anti-inflammatory drugs, smokers, alcoholics, pregnant women or lactating women. Patients who reported strong or very strong sensitivity (scores from 3 to 4) of the 5-point Numerical Scale (NRS: 0 - no sensitivity, 1 - mild, 2 - moderate, 3 - strong and 4 - very strong) were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5yjyr7	Effects of a dual-task aquatic and terrestrial physical exercise program on motor and cognitive functions of individuals with Parkinson&apos;s Disease - AquaDualPark study	Data analysis completed	Intervention	2020-09-11	<NULL>	<NULL>	4239	Parkinson&apos;s Disease and Physiotherapy: Analysis of the impact of intervention programs with terrestrial and aquatic physical activities - FisioPark	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Paraná	Prefeitura Municipal de Curitiba - Secretaria da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-5yjyr7	<NULL>	Diagnosis of idiopathic Parkinson&apos;s disease; Be between stages 2 to 4 of the Hoehn &amp; Yahr scale; Agree to the Free and Informed Consent Form; Present medical certificate clearing to practice physical activity; Present medical certificate clearing to practice aquatic physical activity; Present independent march; Present visual, auditory and cognitive skills to follow verbal instructions during evaluations and interventions	Present changes in the dosage of Levodopa or other Parkinson-related medication during the research; Do not agree with the Informed Consent Form; Do not present a medical certificate clearing to participate in physical activity or for aquatic activity; Present physical or cognitive changes that prevent participation in evaluations and interventions; Do not carry out initial, intermediate and / or final evaluations; Present more than 75% of absences in the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5xg4pk	"Influence of Motivational Interviewing on body measurements and consumption
diet of women with obesity"	Data analysis completed	Intervention	2020-09-11	<NULL>	<NULL>	4241	"Influence of Motivational Interviewing on anthropometric parameters and consumption
diet of women with obesity"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5xg4pk	<NULL>	Adult women aged between 18 and 61 years, all races, with a BMI between 30 and 40 kg/m²	Pregnancy, breastfeeding, inability  to read and interpret dietary prescription or fill food record,  use  of medications for weight reduction, antidepressants, antipsychotics, corticosteroids, lithium, previous diagnosed diabetes, uncontrolled psychiatric diseases, major psychiatric disorders, generalized anxiety, major depression, uncontrolled thyroid diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-4dr59v	Risk factors for caries lesion development and progressionin adolescents	Data analysis completed	Intervention	2020-09-14	<NULL>	<NULL>	4244	Incidence and Progression of Occlusal Caries in Adolescents - Risk Factors	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-07	Faculdade de Ciências da Saúde	Faculdade de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4dr59v	<NULL>	Students (10 to 16 years-old) with at least one permanent second molar partially erupted; students with permanent second molars erupted and in occlusion	Students with the permanent second molars partially erupted with sealants, fillings or cavities; students with the permanent second molars in occlusion with sealants, fillings or cavities;students with cronical diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-973w9d	Effects of cranial sacral therapy associated with mobilization of the uterus to relieve menstrual cramps	Data analysis completed	Intervention	2020-09-18	<NULL>	<NULL>	4254	Skull sacral and uterine mobilization to relieve primary dysmenorrhea	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-03-11	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-973w9d	<NULL>	Women enrolled in the higher education institution - FIS; Age between 20 and 28 years; Clinical diagnosis of dysmenorrhea in her pre-menstrual and menstrual period.	Amenorrhea; Alcoholism; Smoking; Pregnancy; Hysterectomy; Endometriosis; Polycystic ovary syndrome; Myoma; Ovarian cysts; Congenital malformations of the urinary tract; Cervical stenosis; Gynecological consultation for over a year; Make use of Intrauterine Device - IUD; Women using analgesic drugs or muscle relaxants; Women using any other therapy to treat primary dysmenorrhea and associated symptoms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-4ng2m8	Lumbar massage for pain reduction during labor in women from Serra Talhada / PE	Data analysis completed	Intervention	2020-09-18	<NULL>	<NULL>	4255	Efficacy of lumbar massage for pain reduction during the first period of labor in parturients in Serra Talhada / PE	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-4ng2m8	<NULL>	Primiparae and multiparae in active dilation phase; with a single, full-term fetus; aged 15 to 30 years; without usual risk pregnancy: abnormal presentation, diabetes, hypertension, twin pregnancy.	Parturients with indication for cesarean section; all parturients who do not fit the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-554pws	Use of the Healthy Lifestyle Deck of cards in Therapy for Adults with Obesity	Data analysis completed	Intervention	2020-09-18	<NULL>	<NULL>	4263	Healthy lifestyle deck of cards as a tool of Cognitive-behavioral group therapy of Obese adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	UNIFESP	UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-554pws	<NULL>	volunteers between 30 and 60 years old; both genders; BMI between 30 and 39.99	bariatric surgery; participation in previous research by the Obesity Study Group (UNIFESP)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-3gzsnn	Acute effect of Whole-body electrostimulation on cardiovascular and oxygen responses during exercise in obese individuals	Data analysis completed	Intervention	2020-09-20	<NULL>	<NULL>	4265	Acute effect oh Whole-body electromyostimulation on autonomic heart modulation and capacity cardiopulmonary in individuals with obesity	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3gzsnn	<NULL>	Male volunteers; aged between 18 and 40 years; body mass index (BMI) higher than 30 kg/m² were considered obese; BMI between 18.5 to 24.9 kg/m² were considered eutrophic	Smoking volunteers; users of illicit drugs that influence the autonomic nervous system; hypertensive; diabetics; or other cardiorespiratory diseases; history of alcoholism; medication users who could alter the autonomic nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-8c7267	Benefits of functional training in women with knee pain.	Data analysis completed	Intervention	2017-09-15	<NULL>	<NULL>	4268	Effect of neuromuscular training and strengthening of the lower limbs musculature in women with Patellofemoral Pain Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-28	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8c7267	<NULL>	"Subjects must sign the Free and Informed Consent Form before starting the study activities; Aged between 18 and 30 years; 
Active womens, who perform any physical activity up to twice a week; Presence of anterior or retropatellar pain in the knee for at least the last 3 months in two or more of the following activities: running, walking, jumping, climbing and/or descending stairs while remaining seated or kneeling for an extended period of time, Squatting position during the isometric extension of the knee with 60º of flexion, and/or during palpation of the medial or lateral facet of the patella; Presence of dynamic valgus during the unipodal squatting."	Will be excluded, individuals submitted to recent physiotherapeutic treatment; With history of knee surgery; Patellar instability; Ankle or hip injuries; Meniscal or ligament injury; Joint swelling of the knee, or any other specific knee change; Tendinitis in the lower extremity; Low back pain; Pain in the sacroiliac joints; pregnancy; Presence of any neurological disorders / disorders that compromise the understanding of the procedure, or that affect motor control; Any cardiovascular changes and rheumatic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-23r5mc	"The use of gabapentin in the treatment of
keratoconus"	Data analysis completed	Intervention	2020-09-22	<NULL>	<NULL>	4274	The use of gabapentin in the management of postoperative pain in Crosslinking	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade do Oeste de Santa Catarina	Universidade do Oeste de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-23r5mc	<NULL>	Twelve participants with progressive keratoconus who underwent Crosslinking were selected, of both sexes, aged 10 to 40 years.	"Intellectual inability to answer the questionnaire applied in the postoperative period.
Allergy to the drug Gabapentin."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-7cz4sf	Effect of motor and cognitive training of the elderly in relation to the ability to perform daily tasks	Data analysis completed	Intervention	2020-09-23	<NULL>	<NULL>	4278	Effect of Motor-cognitive training (dual task) on the functionality of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7cz4sf	<NULL>	Independent participants in the execution of the march; classified in stages 2 and 3 on the Hoehn and Yahr&apos;s Disability Scale; have preserved capacity for recognizing shapes and numbers; be able to sequence shapes and numbers proposed by the intervention	Participants who needed any kind of assistance to carry out the march; carriers of diseases that would prevent testing; those who were undergoing physiotherapeutic treatment or who were in a long-term institution	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-8h7dmq	Study of the analgesic effect of the medication Allopurinol compared to placebo in patients with Fibromyalgia	Data analysis completed	Intervention	2020-09-23	<NULL>	<NULL>	4284	Study of the analgesic effect of Allopurinol versus Placebo in patients with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-14	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8h7dmq	<NULL>	Female gender; age between 18 and 65 years; functional status class I or II according to the American Society of Anesthesiologists (ASA); patients with fibromyalgia	Previous diagnosis of schizophrenia and other psychotic disorders; history of bipolar disorder; diagnosis of delirium; history of stroke; previous diagnosis of CNS neoplasia; deficit in cognitive or motor development; patients with dialysis renal failure; patients with gout or lithiasic kidney disease; patients who do not understand the Portuguese language or who are illiterate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-6mk8r3	A Program of Health Promotion and Prevention of Damage on Pelvic Floor in Public Workers	Data analysis completed	Observational	2020-09-24	<NULL>	<NULL>	4287	A Program of Health Promotion and Prevention of damage on pelvic floor  in public workers of a brazilian public University	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-02-20	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6mk8r3	<NULL>	The inclusion criteria (IC) will be women between 20 and 60 years old; public workers of university and who aim to participate.	The exclusion criteria (EC) will be women who have some deslocation issue that interfere from going and / or carrying out the activities of the interventions; women who are already doing medical treatment, physical therapy or any other treatment directed to the pelvic floor dysfunctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-8rvrb5	Chlorella supplementation produces anti-inflammatory activity and improves quality of life in pre-diabetic and diabetic patients	Data analysis completed	Intervention	2020-09-24	<NULL>	<NULL>	4288	Modulating activity of the alga Chlorella in glucose intolerant and type-2 diabetic patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Hemocentro Universidade Estadual de Campinas	Hemocentro Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8rvrb5	<NULL>	Healthy, pre-diabetic or diabetic volunteers, attended at CECOM of UNICAMP; both genders; age between 18 and 75 years; continue with their therapeutic treatment; signed informed consent form.	History of drug or alcohol abuse; diagnosis of type 1 diabetes; decompensated blood pressure; diagnoses of severe psychiatric, renal, cardiac, pulmonary, autoimmune diseases, cancer and immunodeficiencies; pregnancy and lactation; hypersensitivity to iodine; use of immunosuppressants and warfarin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-7h7f93	Evaluation of electromyographic activity and cutaneous temperature of the rectus abdominis muscle on exercises on the vibrating platform	Data analysis completed	Intervention	2020-09-24	<NULL>	<NULL>	4291	Evaluation of electromyography and thermography of the rectus abdominis muscle on exercises on the vibrating platform	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-03	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7h7f93	<NULL>	Healthy volunteers; both genders; age between 18 and 30 years; Normal BMI; sedentary; able to perform training on a vibrating platform.	Be performing aesthetic treatment in the abdominal region; practice physical activity regularly; presenting musculoskeletal injuries; have cardiovascular problems; pregnancy; acute low back pain; epilepsy; labyrinthitis; having had abdominal surgery recently; presenting umbilical hernia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-993xf7	Effect of educational booklet on sleep quality of the elderly	Data analysis completed	Intervention	2020-09-25	<NULL>	<NULL>	4292	Effect of printed Educational Technology on the sleep quality of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-993xf7	<NULL>	Being 60 years old or older, living in the urban area, being assisted by the FHS, having good cognitive status, according to the Mini Mental State Examination, according to schooling criteria and sleep quality index greater than or equal to five points on the Pittsburgh Sleep Quality Index PSQI (which corresponds to poor sleep quality or presence of sleep disorder).	present auditory, visual or speech problems, which prevented the application of the instruments; plan to move to another city, have a surgical procedure scheduled, have a medical diagnosis regarding some type of mental illness and anxiety disorder (to obtain information about this criterion, there was questioning the CHWs and triangulation of data, by checking the medical records of the elderly, in the health unit); identification of risk for depression (obtained from the application of the geriatric depression scale); use antidepressant, sedative and psychotropic medications in general, in addition to chronic use of alcohol, cocaine, crack and amphetamines, for directly interfering in the outcome variable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-7xzhkn	Effects of a physical exercise program and health advice on the sedentary behavior of adolescents	Data analysis completed	Intervention	2020-09-29	<NULL>	<NULL>	4306	Stand up: for a healthier life	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7xzhkn	<NULL>	Belong to the seventh, eighth or ninth grade of elementary school; belong to the first year of high school; healthy volunteers; both genders; age between 13 and 16 years.	Age under 13 years; age 17 years or older; physical or mental condition that made it impossible to participate in the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-3h78kz	Topical formulation containing chamomile microparticles with chitosan: study to assess safety and efficacy.	Data analysis completed	Intervention	2016-10-21	<NULL>	<NULL>	4328	Topical formulation containing microparticles Chamomilla recutita (L.) Rauschert coated with chitosan: Phase I clinical study	<NULL>	1, non-randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2015-08-10	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3h78kz	<NULL>	Healthy volunteers; older than 18 years; with integrity skin in sites for the application of products; no history of allergic reactions to shrimp, fish or seafood; no history of allergic reactions to any component of chamomile; no history of allergic reactions to components of the formulations.	Volunteers in current treatment with heparin, oral anticoagulants and antiplatelet agents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-6x6qy2	Comparative study between three types of mouthguards used to prevent lesions in the mouth and influence on mouth functions.	Data analysis completed	Intervention	2020-10-08	<NULL>	<NULL>	4331	"Comparative study of 3 types of mouthguards used in trauma prevention
maxillomandibular and its effects on the function of the oral cavity"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6x6qy2	<NULL>	American football players, from the Bulls Potiguares club, male and registered in the North American League of American football.	Those who used full dentures, removable partial dentures, orthodontic appliances, as well as those who complained of recurrent ulcerations were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-9pw58p	Study on the use of Allopurinol or Placebo on Pain and Anxiety in patients undergoing Abdominal Surgery to remove the Uterus	Data analysis completed	Intervention	2020-10-08	<NULL>	<NULL>	4336	Study on the pre-anesthetic administration of Allopurinol versus Placebo on Pain and Anxiety in patients undergoing Total Abdominal Hysterectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-13	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9pw58p	<NULL>	Female gender; functional status of the American Society of Anesthesiologists (ASA) classes I or II; candidates for total abdominal hysterectomy	Illiterate patients or those who do not understand the Portuguese language; history of psychiatric or neurological symptoms; contraindication for spinal anesthesia; who refuse to participate in the study or who already participate in other studies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-2mf6qg	Monitoring the use of cellular applications for the influence on the behavior of individuals during sun exposure	Data analysis completed	Observational	2020-10-09	<NULL>	<NULL>	4339	EN19-0771-01- Clinical study aiming to monitor the use of mobile applications for their potential of impacting an individual’s sun exposure behavior, by assessing vitamin D synthesis and production of erythema after sun exposure	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-04	Medcin Instituto da Pele Ltda	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2mf6qg	<NULL>	Aged 18 to 50; Phototypes I to III, as per Fitzpatrick classification (Population makeup: Phototype I = 20%; Phototype II= 40%; Phototype III= 40%); Intact facial and body skin; Not taking restrictive diet (or having completed diet at least 6 months before assessment); Have a smartphone (iOS or Android) - minimum requirement iOS 9.0 (or later) or Android 5.0 (or later); In the investigator’s opinion, they are able and willing to comply with all study requirements; Understand, agree and sign the Informed Consent Form.	Pregnancy/breastfeeding or intention to become pregnant; Use of the following topical or systemic drugs: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to 30 days prior to screening or, in the case of immunosuppressants, the interval must be 3 months prior to screening; Use of vitamin D supplements up to 03 months prior to assessment; Planned elective surgery or other procedures that require hospitalization and/or general anesthesia during the study; Use of topical or systemic photosensitizing medication up to 01 month prior to screening; History of phototoxic or photoallergic reactions; Photoinduced pathologies, such as solar urticaria, lupus erythematosus, polymorphic light eruption, simple recidivating herpes; Vitiligo; Atopical or allergic histories to cosmetics; Pathologies and/or active skin lesions (local and/or spread) on the assessment site; Skin marks on the experimental site that interfere with the assessment of possible skin reactions (vascular malformations, scars, increased pilosity, big amount of nevus, sunburns); Immunosuppression by drugs or active diseases; Subjects bearers of known congenital or acquired immunodeficiency; Relevant clinical history or current evidence of abuse of alcohol or other drugs; Known history or suspected intolerance to sunscreens; Moderate/intense solar exposure up to 03 months prior to assessment; Aesthetic or dermatological treatment on the assessment site up to 04 months prior to screening; Other conditions considered by the assessing physician as reasonable to disqualify the clinical study subject. If so, it must be written under observation in the clinical record.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-48c9xt	Effect of ibuprofen + caffeine administration on the reduction of dental sensitivity from in-office bleaching	Data analysis completed	Intervention	2018-08-28	<NULL>	<NULL>	4344	Effect of anti-inflammatory administration on the reduction of dental sensitivity from in-office bleaching	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-48c9xt	<NULL>	Patients will be included who are older than 18 years of age with good oral and general health; have their maxillary anterior teeth free from restorations and carious lesions; with color A2 or darker according to the Classical Vita scale (Vita Zahnfabrik, BadSäckingen, Germany); and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; severe browning (staining by tetracycline; fluorosis or endodontics); people with dental prostheses and orthodontic appliances and any other oral pathology. Patients will be excluded that present changes stomach; heart; kidney and liver problems; diabetes; hypertension or are making continual use of drugs with analgesic and anti-inflammatory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-2hjj7g	Effects of different types of physical exercise programs on the physical and mental health of the elderly	Data analysis completed	Intervention	2020-10-27	<NULL>	<NULL>	4349	Effects of different types of physical exercise programs on physiological, functional, cognitive and emotional variables in elderly individuals	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual de Londrina	Ministério da Educação	https://ensaiosclinicos.gov.br/rg/RBR-2hjj7g	<NULL>	Elderly aged 60 or over; physically independent; normal mental state; non-participants in guided physical exercise programs in the last three months at the beginning of the study.	Orthopedic problems; diseases that make physical training impossible to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-386rm8	Effects of Electro-stimulation combined with Blood Flow Restriction affected by spinal injury muscles	Data analysis completed	Intervention	2020-10-31	<NULL>	<NULL>	4358	Effect of Neuromuscular Electrostimulation combined with Blood Flow Restriction on muscle thickness and reflex responses in people with spinal cord injury	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-386rm8	<NULL>	Men volunteers with complete spinal cord injury (ASIA A) and eligible for quadriceps responsiveness.	Cauda equina injury; spinal shock; venous thrombosis; autonomic dysreflexia; vascular complications; pressure ulcers; osteoporosis; recent fracture; implants and femur metal pins and two consecutive absences to the training sessions as well.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-5mhdrh	Therapeutic effects of Andiroba oil on oral Wounds induced in children with Cancer under Chemotherapy	Data analysis completed	Intervention	2020-11-03	<NULL>	<NULL>	4361	Evaluation of the therapeutic effects of Andiroba - carapa guianensis aubl (meliceae) - in induced Oral Mucositis in children with Cancer undergoing Chemotherapy	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal do Pará	Hospital Ophir Loyola	https://ensaiosclinicos.gov.br/rg/RBR-5mhdrh	<NULL>	Both genders; volunteers with leukemia; age between four and twelve years; chemotherapy with methotrexate	Recent oral surgery; HIV positive patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-5vkzjt	Nutritional assessment in hospitalized patients	Data analysis completed	Observational	2020-11-03	<NULL>	<NULL>	4363	Nutritional assessment in hospitalized patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Franciscana	Universidade Franciscana	https://ensaiosclinicos.gov.br/rg/RBR-5vkzjt	<NULL>	Adult and elderly hospitalized patients; of both genders; patients admitted to any medical clinic; enteral nutrition; oral nutrition.	Anasarca patients; sepsis patients; intensive care unit patients; parenteral nutrition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-8rfwnq	Evaluation of the preventive effect of anti-inflammatory drugs in extractions of third molars.	Data analysis completed	Intervention	2019-09-20	<NULL>	<NULL>	4365	Comparative evaluation of the anti-inflammatory effect of Ibuprofen, Etodolac, Loxoprofen, and Dexamethasone  associated with preemptive analgesia, in lower third molar Surgeries	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2014-01-01	Faculdade de Odontologia campus de Araçatuba unesp	Faculdade de Odontologia campus de Araçatuba unesp	https://ensaiosclinicos.gov.br/rg/RBR-8rfwnq	<NULL>	Participants met the inclusion criteria determined by means of anamnesis, clinical, and radiographic examinations. Included patients comprised those in good systemic and general health condition, between 16 and 35 years of age, and those with an indication of lower third molar (#38 or 48) removal, with at least 2/3 of the root formed, according to the radiographic evaluation (Class I or II; Position A/B from Pell &amp; Gregory, 1942).	Participant exclusion criteria was also obtained by means of anamnesis, clinical, and radiographic examinations 6- 8- 9- 11- 14- 23- 24; they included all the opposite questions regarding the inclusion criteria plus the individuals who used any drug in the 30 days prior to the surgical procedure, and female patients during menstrual, gestational, or lactation periods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-6wrjqr	Electrical stimulation and exercises to reduce abdominal subcutaneous fat	Data analysis completed	Intervention	2020-11-10	<NULL>	<NULL>	4368	Electrolipolysis and exercises to reduce abdominal subcutaneous fat	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-04	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-6wrjqr	<NULL>	Female; aged between 20 and 35 years; sedentary; overweight; abdominal plicometry and supra iliac equal to or greater than 2 cm; healthy subjects	Do not attend two sessions in a row; not completing the assessment procedures; change eating habits for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-74hgdr	University teachers&apos; attitudes towards suicidal behavior	Data analysis completed	Intervention	2020-10-29	<NULL>	<NULL>	4372	"Attitudes and reactions of university professors, exposed to training, in the face of suicidal behavior after validation and adaptation of the Eskin&apos;s Attitudes Towards Suicide Scale (E-ATSS) and
Eskin&apos;s Social Reactions to Suicidal Persons Scale (E-SRSPS)"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-02	Hugo Gedeon Barros dos Santos	Universidade Federal de Mato Grosso UFMT	https://ensaiosclinicos.gov.br/rg/RBR-74hgdr	<NULL>	Being a professor at UFMT - campus Cuiabá	All professors belonging to the Psychology course were excluded from the study, and those who in the Nursing and Medicine courses taught disciplines in the area of mental health / psychiatry. This exclusion occurred in order to avoid a selection bias, as studies show that health professionals who are close to aspects of the psi area tend to have more positive attitudes towards suicidal behavior.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-5tf7ss	Body Perception treatment for women with eating disorders	Data analysis completed	Intervention	2020-11-11	<NULL>	<NULL>	4373	The Body Perception Therapy in women with Eating Disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-05	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-5tf7ss	<NULL>	To have clinical diagnosis of anorexia nervosa and bulimia nervosa; overestimation or underestimation in the Body Perception Index;age between 18 and 45 years; in the case of patients with anorexia nervosa, BMI below 18	Psychotic patients with severe depression	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-9y7j6g	Evaluation of the use of Magnesium to prevent Hearing Loss caused by loud sounds	Data analysis completed	Intervention	2020-11-13	<NULL>	<NULL>	4374	Analysis of Magnesium as otoprotector in Noise-Induced Hearing loss	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-12	Setor de saúde auditiva do Hospital Universitário de Brasília	Setor de saúde auditiva do Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9y7j6g	<NULL>	Students aged 17 to 30 years; presenting no self-reported comorbidities; had no previous history of using ototoxic drugs; no amplified music exposure in the past 24 hours before the investigation; no history of middle ear infection; no auditory complaints; and a normal serum magnesium level evaluated at a maximum of 1 month before the investigation	Comorbidities; previous history of using ototoxic drugs; previous exposure to music in the last 24 hours;auditory complaints; no normal serum magnesium level evaluated at a maximum of 1 month before the investigation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-5d4xkm	"Auriculotherapy in the adult chemotherapy clinic: a complementary proposal
combined with nursing care to relieve nausea and vomiting"	Data analysis completed	Intervention	2020-11-17	<NULL>	<NULL>	4377	"Auriculotherapy in the adult chemotherapy clinic: a complementary proposal
combined with nursing care to relieve nausea and vomiting"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-27	Universidade Federal Fluminense	Instituto Nacional de Câncer José Alencar Gomes da Silva	https://ensaiosclinicos.gov.br/rg/RBR-5d4xkm	<NULL>	Adult men aged 18 to 59 years diagnosed with cancer, undergoing chemotherapy from the second cycle with protocols with the following drugs with a high degree of emetogenicity: Combination AC (Doxorubicin + Cyclophosphamide), Carboplatin (AUC greater than or equal to 4mg / m²), Cisplatin, Cyclophosphamide (greater than or equal to 1500mg / m²), Dacarbazine, Doxorubicin (greater than or equal to 60mg / m²), Epirubicin (greater than 90mg / m²) and Ifosfamide (greater than or equal to 2g / m²). In addition, patients with previous experience of nausea and vomiting regarding previous chemotherapy and presentation of the KPS (Karnofsky Performance Status) scale above 70%.	Adult men with cognitive deficit described in medical records; with previous gastrointestinal diseases or previous anti-ulcer treatment; cancer located in the stomach, due to the interference of the disease in the control of nausea and vomiting; neoplasms located in the Central Nervous System (CNS), as they can interfere in the center of vomiting; previous history of allergy to antiallergic micropose patch or any other patch currently available; patients who started outpatient chemotherapy but were hospitalized, for some reason, and continued inpatient chemotherapy, as they receive intravenous antiemetic medication every 8 hours and prolonged venous hydration, which could be a bias for the research. And previous history of use of antiemetics that are not standardized by the hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-464nctz	Integrative medicine Pranic Healing as adjuvant and effective treatment therapy: reduce the Chronic Pain	Data analysis completed	Observational	2020-11-25	<NULL>	<NULL>	4384	Effect of Pranic Healing on the quality of life of young adults	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Ruth Nobuko Nakabayashi	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-464nctz	<NULL>	"534 subjects between 10 and 90 years. 203 subjects filled the inclusion criteria, 177 subjects reported pain symptoms: 32 subjects with medium pain and 145 subjects with high chronic pain

The Confidential Treatment Form of the Institute for Inner Studies, Inc (IIS) Pranic Healing Certification (FTC-CPH) program is completed and signed, before and after receiving PH care. For the assessment of pain, the Visual Analog Scale – EVA was used, on an intensity scale from 0 to 10, where zero is the total absence of pain and 10 is the maximum pain limit."	331 individuals who did not complete the Pranic Healing Certification Program (FTC-CPH) Confidential Treatment Form (FTC-CPH) of the Institute for Inner Studies, Inc (IIS) correctly, or did not sign and did not report after receiving treatment with Pranic Healing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-2nhqjnn	Effectiveness of a Quality of Life Program in reducing stress in parents of Autistic Children	Data analysis completed	Intervention	2020-11-30	<NULL>	<NULL>	4391	Effectiveness of a Quality of Life Program in reducing stress in parents of Autistic Children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-31	Daniele Leite de Barros Carvalho	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2nhqjnn	<NULL>	Caregiver of a person diagnosed with Autism Spectrum Disorder; Aged 18 or over; no acute mental disorder.	"Not being able to attend the 8 weekly meetings;
Cognitive impairment; having participated in a Mindfulness-based program before."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-5fx9cvc	Use of animal derived bone substitutes in oral reahabilitation	Data analysis completed	Intervention	2020-11-30	<NULL>	<NULL>	4392	Xenogenous bone grafts	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-02	Universidade Estadual Paulista, Faculdade de Odontologia de Araraquara	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5fx9cvc	<NULL>	"adult (over 18 years old);
any sex;
with totally edentulous maxillary ridge;
remaining alveolar bone width between 2 and 10mm;
remaining alveolar height of at least 10mm."	"Smokers;
chronic unstable systemic illnesses;
pregnant or nursing women;
under chemotherapy or radiotherapy;
with active sites of infection;
who take medications which affects the bone metabolism;
with recent extraction socket in the area of interest;
patients with bad oral habits that could affect the bone repair."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-5mfy5tx	Use of Metamizole in a Brazilian population	Data analysis completed	Observational	2020-12-02	<NULL>	<NULL>	4395	Characteristics of the use of metamizole for pain and fever in a Brazilian population: Real-world analysis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Sanofi-Aventis Farmacêutica Ltda.	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5mfy5tx	<NULL>	"Cohort 1: metamizole-based cohort
Any patient active in the system with at least one record of metamizole prescription during the study period.

Cohort 2: symptoms-based cohort
-Any active patient in the system with at least one record of headache, migraine or fever between December 1, 2016 and March 31, 2017 or between May 1, 2017 and August 31, 2017."	"Cancer (oncology patients under treatment during the period of the study);
Rheumatic and autoimmune disorders (Rheumatoid arthritis, Ankylosing spondylitis, Crohn’s disease, Ulcerative colitis, Psoriasis or psoriatic arthritis, Lupus, Fibromyalgia, Osteoarthritis);
Pregnancy (during the period of the study, not including c-section post-operative use, i.e., metamizole use post-delivery will be included);
History of metamizole allergy, including anaphylactic reactions;
Haematological history: bone marrow dysfunction;
Deficiency of glucose-6-phosphate dehydrogenase (G6PD);
Had an invalid Amil member identification;
Denied having used the drug."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-5yd3yym	Physiology of Facemask Exercising	Data analysis completed	Intervention	2020-12-07	<NULL>	<NULL>	4401	Physiological effects of physical activity with the use of cotton facemask and TNT	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-25	Laboratorio de Performance Humana	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5yd3yym	<NULL>	The inclusion criteria were men or women aged&gt; 18 years old who had a normal health screening within the last 12 months and no chronic comorbidities and were currently cycling at least 3 times a week either for sport or recreationally.	Not finish at least 50% of facemask exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-7rgyfvs	Effects of Yoga practice on the health of schoolchildren	Data analysis completed	Intervention	2020-12-08	<NULL>	<NULL>	4403	Effects of Yoga practice on the health of schoolchildren with a focus on elementary school I: randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-16	Escola de Artes, Ciências e Humanidades - EACH/USP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7rgyfvs	<NULL>	Children from 7 to 11 years old; students of public school; belonging to Elementary School I; living in the periphery of the city and of both sexes.	Children with a psychiatric disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-8c57nsb	Evaluation of the effectiveness of using an experimental positioner to dissociate root canals in endodontic treatments	Data analysis completed	Intervention	2020-12-09	<NULL>	<NULL>	4405	Experimental positioner to assist the clark technique in radiographs for endodontics	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de odontologia UFPA	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-8c57nsb	<NULL>	Both genders; Patients in need of endodontic treatment, in multiradicular teeth, with root overlapping initial periapical radiographs; Ages from 18 years old; Absence of severe pathologies and syndromes that interfere with treatment; Accept to participate in the research and sign the informed consent form TCLE	Patients who do not require endodontic treatment in multi-dental;Absence of root overlap in the multidental tooth to be treated;Patients who do not agree to participate in the research TCLE; Patients with presence of severe pathologies and syndromes that interfere in the treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-7wqfmsk	In vivo evaluation of the efficacy of teeth whitening treatments using bleaching gel, light treatment and the combination of both	Data analysis completed	Intervention	2020-12-11	<NULL>	<NULL>	4414	Teeth whitening using bleaching gel and light	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-19	Instituto de Fisica de São Carlos - Universidade de São Paulo	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7wqfmsk	<NULL>	Normal health condition; older than 18 years old; males or females; with complete dentition, ie, presence of all anterior teeth plus the permanent superior and inferior pre-molars and first molars	Individuals of 18 years old or younger; uncontrolled systemic diseases; pregnant women; smokers; volunteers that reported previous reaction to peroxides and presence of staining caused by tetracycline or fluorosis; volunteers who did not agree with the specified teeth whitening protocol (patients were oriented to avoid the following foods and beverages in the 48 hours following the end of the dental bleaching treatment: black tea, coffee, red wine, sodas, dark green vegetables, tomato sauces, sauces containing dyes, grape juice and beetroot).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-9yt2g83	Verification of the functioning and undesirable effects of the use of Tranexamic Acid (Transamin) to control bleeding in tonsill surgery	Data analysis completed	Intervention	2020-12-14	<NULL>	<NULL>	4416	Effectiveness and adverse effcts of Tranexamic Acid use in control of bleeding inherent to Tonsillectomy surgeries with Adenoidectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-14	Associação Paranaense de Cultura	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-9yt2g83	<NULL>	Be under 12 years old; tonsillectomy indication due to recurrent infections or adenotonsillar hypertrophy.	Suspected von Willebrand type 1 disease; operation in the last two months; with a history of infectious processes in the last month; altered coagulogram; other coagulation disorders; use of drugs that can interfere with blood coagulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-32nyht	Fluoride varnish and resin-modified glass ionomer cement sealant to arrest active occlusal carious lesions in erupting permanent molars: a randomized clinical trial	Data analysis completed	Intervention	2020-04-16	<NULL>	<NULL>	4422	Non-invasive treatment of enamel Caries Lesion on occlusal surfaces of permanent molars at different eruption stages	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-02	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-32nyht	<NULL>	Children presenting good general health with cooperative behavior that did not refuse with the completion of clinical procedure with at least one erupting permanent molar with active enamel carious lesion on the occlusal surface were included in this study.	Childern without caries lesions or with teeth with occlusal surfaces totally covered by gingival tissue, presenting hypoplastic defects, restorations, or sealants were not included in the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-4pgktym	Dentoskeletal and upper airway changes after micro-implant-assisted palatal expansion (MARPE) in patients in the final stages of suture fusion: a randomized controlled clinical trial	Data analysis completed	Intervention	2020-12-17	<NULL>	<NULL>	4431	"Analysis of the anteroposterior and vertical effects in the final stages of suture fusion
intermaxillary after using the Palatino Rapid Expander assisted by Mini-Implants"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Centro Universitário da Fundação Hermínio Ometto	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4pgktym	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 60 years; presence of maxillary atresia; ossification level of the complete palatal suture.	Syndromic volunteers; history of orthodontic treatment; history of craniofacial bone fractures; diagnoses of bone or metabolic pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:11
RBR-45zfr4b	Benefits of innovative treatment for women with fibromyalgia: a procedure to follow	Data analysis completed	Intervention	2020-12-18	<NULL>	<NULL>	4436	Benefits of repetitive intravenous lidocaine infusions in patients with fibromyalgia syndrome and the relationship with inflammatory biomarkers: a procedure to follow	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-05-07	Universidade Federal de Sergipe	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-45zfr4b	<NULL>	Female; between 35 and 65 years old, previously diagnosed with fibromyalgia by an experienced anesthesiologist according to the criteria of the American College of Rheumatology, in the chronic pain outpatient clinic of the University Hospital of the Federal University of Sergipe.	Hypersensitivity to the tested drugs; Recent injury or trauma; diagnosis of epilepsy, psychiatric disorders,rheumatic disorders, moderate or severe neuromuscular disorders, hypothyroidism or hyperthyroidism, arthropathy, infectious disease, another chronic pain syndrome, neoplasms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-10m379hg	Comparison of trunk and leg muscle activities in hippotherapy and walking in healthy individuals	Data analysis completed	Intervention	2020-12-23	<NULL>	<NULL>	4438	Electromyographic analysis of muscle activation of the trunk and lower limbs in hippotherapy compared to the gait of healthy individuals	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Triângulo Mineiro	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-10m379hg	<NULL>	independent walking; both genders; age between 19 and 24 years old; the signature of the term of responsibility for the practice of hippotherapy; signed free and informed consent term; sedentary lifestyle; assessed using the IPAQ; irregular activity Was defined as a physical activity performed at a frequency of up to 5 days/week or a maximum duration of 150min/week; although sedentary; all the participants were healthy and in good general condition.	Abandonment;  absence on the day of collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-8pbydg	Effect of irradiation with violet light on the clinical performance of dental bleaching of low concentration bleaching agents.	Data analysis completed	Intervention	2017-08-29	<NULL>	<NULL>	4446	Effect of irradiation with violet light on the clinical performance of dental office whitening performed with 6% hydrogen peroxide containing TIO2_N nanoparticles and their impact on quality of life - Randomized Clinical Study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade de Odontologia de Araraquara	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-8pbydg	<NULL>	"Young adult patients from Araraquara and surrounding regions; over 18 years of age; of both genders; with good general health condition; who
Have teeth from 14 to 24 and from 34 to 44 healthy and aligned; without lesions of caries; hypoplasia of the enamel; staining by tetracycline or fluorosis &gt; TF2."	"Infants; Pregnant women; Smokers; Patients with parafunctional habits (bruxism and / or tightening); Gingival recession; Incisal wear; injuries
Of erosion; Abrasion or abfraction; Chronic analgesic / anti-inflammatory users and desensitizing toothpaste."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-34r4dz	Clinical performance of whitening toothpaste	Data analysis completed	Intervention	2017-08-24	<NULL>	<NULL>	4447	Clínical performance of a new Whitening Dentifrice containing optimized abrasive particles, desensitizing agent and dyes for optical whitening effect - Clínical Randomized Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Faculdade de Odontologia de Araraquara	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-34r4dz	<NULL>	"Volunteers of both genders; over 18 years of age; who have at least 20 natural teeth in the oral cavity; and at least 6 incisors and
Superior canines without caries; restorations or prostheses."	Pregnant women and infants will be excluded from the study; and volunteers with systemic diseases;  xerostomia; acid erosion; bruxism; touth breathing; dental crowding and orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-426n79	Clinical Performance of Antiseptic Anti-stain	Data analysis completed	Intervention	2017-09-21	<NULL>	<NULL>	4448	Clinical Performance of Antiseptic Copolymer Whitening - Clinical Study Randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Faculdade de Odontologia de Araraquara	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-426n79	<NULL>	Volunteers of both genders; older than 18 years; that have at least 20 natural teeth in the oral cavity, being incisors and the superior canines without caries, restorations or prostheses.	Pregnant and lactating;patients with systemic diseases; xerostomia; acid erosion; bruxism; mouth breathing; dental crowding; patients undergoing orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-64f7rct	A comparative study between Cryosurgery and Conventional Surgery in Oral Lesion Blister treatments A comparative study between cryosurgery and conventional surgery in oral mucoceles treatments	Data analysis completed	Intervention	2020-12-29	<NULL>	<NULL>	4450	A comparative study between Cryosurgery and Conventional Surgery in Oral Mucoceles treatments	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2017-02-06	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-64f7rct	<NULL>	Patients of both sexes; with oral lesions clinically compatible with mucoceles; round well-circumscribed; bluish or transparent and with a history of local trauma	Patients treated with antimicrobials; analgesics or anti-inflammatories; with a history of any type of oral surgery for less than thirty days or with symptomatic oral lesions of any nature	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-9zqkvbs	Noninvasive brain stimulation in children and adolescents with attention deficit hyperactivity disorder	Data analysis completed	Intervention	2021-01-05	<NULL>	<NULL>	4457	Transcranial direct current stimulation in children and adolescents with attention deficit hyperactivity disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-30	Universidade Federal de São Paulo - Unifesp	Universidade Federal de São Paulo - Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-9zqkvbs	<NULL>	Having a diagnosis of attention deficit hyperactivity disorder; age between 7 and 12 years; inserted in a regular school environment; have a degree of understanding and collaboration compatible with the performance of activities tenders; the guardians agree to their participation in the study by signing the Free and Informed Consent Form.	Children with epilepsy; metal implant in the brain or hearing aids; intellectual, sensory or motor disabilities that limit the performance of the neuropsychological procedures proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-4mjz3wj	Perception of vocal complaint and self-assessment of the impact of a voice problem on theater actors	Data analysis completed	Observational	2021-01-05	<NULL>	<NULL>	4461	Vocal symptoms, vocal tract discomfort and vocal handicap perceived in professional theater actors	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-08-01	Centro de Estudos da Voz (CEV)	Centro de Estudos da Voz (CEV)	https://ensaiosclinicos.gov.br/rg/RBR-4mjz3wj	<NULL>	Age between 18 and 64 years;Registration at the Regional Labor Office;of both genders; with or without vocal complaints;professional performance in theater plays for at least one year; be on display during the data collection period; self-assessment questionnaires on the impact of dysphonia answered in a complete way	Acting exclusively on television; musical theater	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-9tqpsvy	Acute effect of core stability and sensory-motor exercises on postural control during sitting and standing positions in young adults	Data analysis completed	Intervention	2021-01-07	<NULL>	<NULL>	4466	Analysis of the impact of motor sensory exercises and lumbar stabilization in neuromuscular responses during sitting and standing position in adults and elderly.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9tqpsvy	<NULL>	Both sexes; be healthy; did not participate in physical exercise programs	Present low back pain; absence of any musculoskeletal, joint or overall health conditions that limit implementation of the study protocol or not able to perform the proposed exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-6hyt5g7	Relationship between pain and sleep and the effects of physiotherapy on these parameters in individuals with CMT disease	Data analysis completed	Intervention	2021-01-07	<NULL>	<NULL>	4467	Relationship between pain and sleep quality and the effects of the physiotherapy on sleep pattern and pain parameters in individuals with CMT type 1 and 2 disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Associação Fundo de Incentivo à Pesquisa - AFIP	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-6hyt5g7	<NULL>	Clinical and electromyographic diagnosis of CMT disease; both sexes; age between 16 and 65 years	Acute or chronic lung disease; cognitive or psychiatric alterations; severe or non controlled hypertension; heart failure; chronic renal disease; severe systemic disease; diabetes mellitus; pregnant women; obesity; active smokers; alcoholics; refused to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-5m53mhb	Studies on body posture, low back pain and neck pain and their associated factors	Data analysis completed	Observational	2021-01-13	<NULL>	<NULL>	4471	Studies on body posture, low back pain and cervical pain and their associated factors	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-02-15	Escola de Educação Física, Fisioterapia e Dança da Universidade Federal do Rio Grande do Sul (UFRGS)	Escola de Educação Física, Fisioterapia e Dança da Universidade Federal do Rio Grande do Sul (UFRGS)	https://ensaiosclinicos.gov.br/rg/RBR-5m53mhb	<NULL>	Presence of chronic low back pain in the last 3 month; occurrence of monthly or weekly episodes of low back pain; completion of all information of three questionnaires (Back Pain and Body Posture Evaluation Instrument, BackPEI-A, Oswestry Disability Index, ODI, and Fear-avoidance Beliefs Questionnaire, FABQ-Brazil); age between 18 and 59 years; and both genders.	Previous spinal surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-2qyrrns	Effect of the photostimulation to improve muscle performance of lower limbs in functional test	Data analysis completed	Intervention	2021-01-14	<NULL>	<NULL>	4473	Temporal effect of a single session of cluster phototherapy on lower limb muscle fatigue in sedentary young adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2qyrrns	<NULL>	Volunteers sedentary; healthy; aged between 18 and 18 years; both sexes	Volunteers with neurological and cognitive impairments; cardiorespiratory diseases; the history of orthopedic and traumatological disorders in the lower limbs or trunk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-2x56pw8	Angiotensin-(1-7) oral formulation improves physical performance in mountain bike athletes	Data analysis completed	Intervention	2021-01-11	<NULL>	<NULL>	4474	Effect of the oral formulation Hpbcd / Angiotensin- (1-7) in the treatment of muscle microlesion induced by sports practice	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-03	Grupo de pesquisa em Mecanofisiologia	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-2x56pw8	<NULL>	healthy volunteers; of both genders; older than 18 years; impeded in their cycling training programs for at least 12 months; conduct at least four MTB training schools per week.	make use of supplements with a potential stimulating effect on the cardiovascular system (such as caffeine and guarana powder); history of current injuries or in the last six months; not willing to abstain from intense exercise 24 hours before the test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-42sg8j2	Anxiety and Depression Diagnosis and Treatment	Data analysis completed	Intervention	2021-01-26	<NULL>	<NULL>	4489	Depression and Anxiety Ambulatory: Study about Clinical Profile, diagnosis and mental health therapy short-course.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal do Pará	Hospital Universitário Bettina Ferro de Souza	https://ensaiosclinicos.gov.br/rg/RBR-42sg8j2	<NULL>	Volunteer patients,aged between 18 and 30 years old, of both sexes, who reported having depressive symptoms, but were not undergoing psychotherapeutic or psychopharmacological treatment; who were interested in knowing, studying and practicing the art of clowning; that they did not have physical limitations that would prevent them from practicing the exercises proposed during the workshop; and who agreed to participate in the study by signing the Informed Consent Form (ICF).	Patients under 18 years old or over 75 years old, who had physical dissipation that prevented them from practicing the exercises proposed during the workshop	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-3n5ckxn	Cosmetic product for treating cellulite with caffeine associated with ionic liquid	Data analysis completed	Intervention	2021-02-03	<NULL>	<NULL>	4500	Cosmetic Product for Treatment of Ginoid Hydrolipodystrophy with Caffeine Associated with Ionic Liquid	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-20	Universidade de Sorocaba	Universidade de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-3n5ckxn	<NULL>	being a healthy female, aged between 18 to 55 years old; without any skin problem, such as the presence of dermatitis or wounds.	the manifestation of any type of allergy or skin irritation by the applied product; history of allergic manifestations and lack of availability to attend the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-5nj644k	The effects of electrical stimulation of the entire body after stomach reduction surgery.	Data analysis completed	Intervention	2021-02-05	<NULL>	<NULL>	4516	Functional, clinical, and systemic effects of Whole-body electromyostimulation in the postoperative period of bariatric surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5nj644k	<NULL>	Bariatric Bypass Surgery Candidates between 20 and 50 years.	Volunteers with orthopedic or neurological impairments; myocardial infarction within the six-month period from the beginning of the study; implanted pacemaker or any metallic synthesis; unstable angina; chronic heart rhythm disorders; moderate or severe valvular heart disease; history consistent with heart disease; uncontrolled arterial hypertension; uncontrolled and or insulin-dependent diabetes mellitus; use of beta-blockers; postmenopausal women; participation in a regular exercise program at the beginning of the study; respiratory diseases; contraindication to the ergospirometric test; condition that could compromise the performance of functional tests such as distal arteriopathies; inflammatory diseases; kidney disease; liver diseases with diabetic neuropathy; cognitive deficit; difficulty understanding or adhering to the study procedures; declared users of illicit drugs and pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:19
RBR-65hhc4n	Effects of radiofrequency associated with manual lymphatic drainage and vibrating platform to reduce cellulite	Data analysis completed	Intervention	2021-02-08	<NULL>	<NULL>	4519	Effects of radiofrequency associated with manual lymphatic drainage and vibrating platform on the improvement of fibroid edema	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Integração do Sertão	Faculdade de Integração do Sertão	https://ensaiosclinicos.gov.br/rg/RBR-65hhc4n	<NULL>	Age between 20 and 25 years, Ginoid Hydrolipodystrophy in grades I or II, availability to participate in the interventions (twice a week), phototype II, III and IV according to the Fitzpatrick classification and body mass index (BMI) between 18, 5 and 24.9	Having obesity, smoking, cardiovascular and metabolic diseases, difficulties in understanding simple verbal command, performing physical activity frequently, having a diagnosis of some neurological sequel and some level of lower limb amputation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-2h745w	Clinical and radiographic comparison of dental implants placed by conventional surgery and guided surgery with virtual planning	Data analysis completed	Intervention	2018-07-23	<NULL>	<NULL>	4525	Clinical and radiographic comparison of dental implants placed by conventional surgery and guided virtual surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2h745w	<NULL>	Sufficient bone structure for conventional length implants insertion, verified by CBCT; suitable mouth opening for surgical and tomographic guides, as well drill guides and drills for GVS technique; presence of both teeth adjacent to the dental element that was rehabilitated, for stabilization of the guides.	Anatomical limitation for dental implants placement or the need of bone grafting prior to implantation; patients with inflammatory alterations at the surgical site; limited prosthetic space that can preclude the restauration; pregnant or lactating women; presence of metabolic, hemorrhagic and relevant systemic disorders that could alter the tissues reparation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-2ybrb4d	Use of laser in the treatment of injuries caused by Radiotherapy	Data analysis completed	Intervention	2021-02-09	<NULL>	<NULL>	4527	Prevention of Oral mucositis induced by Radiotherapy of head and neck: effect of the combination of red and infrared lasers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade de Passo Fundo	Associação Hospitalar Beneficente São Vicente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2ybrb4d	<NULL>	Be over 18 years old; having an indication for outpatient radiotherapy treatment for head and neck cancer with or without adjuvant chemotherapy; present physical and psychological conditions to receive the treatments proposed in the methodology of this research; having signed the free and informed consent form.s	Patients undergoing clinical complications that prevent the study, such as interruption of radiotherapy for more than a week or limited mobility, will be excluded from the research; patients who refuse to apply the therapy within the proposed treatment logistics or who do not adhere to the requested oral hygiene protocol.s	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-52j6gmg	Efficacy of At-Home Dental Bleaching in Patients with Aesthetic Restorations	Data analysis completed	Intervention	2021-02-05	<NULL>	<NULL>	4540	Efficacy and Safety of At-home Detal Bleaching in Individuals with Aesthetic Restorations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-52j6gmg	<NULL>	"To have all six anterosuperior teeth with tooth color mean A2 or darker;
At least 18 years of age;
To have good oral health condition (absence of active caries or periodontal disease in the anterosuperior elements);
The patient reports having a good general health condition (absence of heart problems, hypertension or decompensated diabetes)."	"Pregnant or lactating women;
Individuals with evident malocclusion or undergoing orthodontic treatment;
Individuals with endodontic treatment in any of the anterior teeth;
Individuals who had undergone some whitening treatment in the previous three years;
Smokers;
Loss or fracture of an anterior superior tooth;
Presence of teeth with abrasion, erosion or abrasion injuries;
History of previous hypersensitivity;
Presence of structural defects on the enamel surface;
Presence of parafunctional habits (bruxism, tightening)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-63rn74y	Teacrine supplementation and motor performance of amateur athletes	Data analysis completed	Intervention	2021-02-12	<NULL>	<NULL>	4546	Effects of teacrine supplementation on motor performance and IGF system in amateur athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-63rn74y	<NULL>	Males aged 18 and 25 years with at least one year of experience in the sport	Use any type of supplementation, use or have used anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-49q54wg	Anti-inflammatory activity of Physalis-based cream after laser application in the treatment of spots on the hands	Data analysis completed	Intervention	2021-02-12	<NULL>	<NULL>	4550	Anti-inflammatory activity of the cream based on Physalis angulata L. extract after application of intense pulsed light in the treatment of solar melanosis of the hands	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-49q54wg	<NULL>	Healthy volunteers; both genders; ages between 26 and 76 years; non smokers; weight within the range of 15% of the weight considered normal for men and women taking into account height and physical structure; similar involvement by melanosis in both hands; negative dermoscopy for premalignant lesions; phototype between I to IV.	Volunteers with autoimmune diseases; hives; photosensitivity; previous history of skin cancer; pre-malignant lesions on the skin; signs of loss of skin barrier in the treated region; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-10j7gj5w	Impact of pharmaceutical care on the health outcomes in patients with systemic arterial hypertension and different care needs: a randomized controlled trial	Data analysis completed	Intervention	2021-03-01	<NULL>	<NULL>	4561	Validation of patient selection indicators for insertion in a pharmaceutical care service focused on primary care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-15	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-10j7gj5w	<NULL>	Individuals attended by the Basic Health Unit pharmacy; age 18 years or older; diagnosis of Systemic Arterial Hypertension; use of at least one antihypertensive medication	Individuals who did not attend the first consultation; individuals who did not attend the monthly meetings for more than four consecutive months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-4jzzh5p	Study of microcirculation in children with Severe Generalized Infection admitted to the IFF-Fiocruz unit of severe patients	Data analysis completed	Observational	2021-03-02	<NULL>	<NULL>	4563	Microhemodynamic evaluation in children with Severe Sepsis and / or Septic Shock admitted to the IFF-Fiocruz unit of severe patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2010-07-12	Instituto Fernandes Figueira	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4jzzh5p	<NULL>	Children admitted to the unidadae de pacientes graves (UPG) of Instituto Fernandes Figueira (IFF) Fiocruz;  ages between one month and 18 years; diagnosis of severe sepsis or septic shock;  indication of mechanical ventilation; in the case of control patients children hospitalized for elective minor surgery.	Children with body mass below 3kg;contraindications to dark field sidestream device (SDF) assessment as severe bleeding in the sublingual mucosa or malformation of the face that prevented the opening of the mouth;contraindications to indirect calorimetry monitoring or factors that decrease the accuracy of the method  such as need for mechanical ventilation with inspired oxygen fraction (FiO2) greater than 85%, need for mechanical ventilation with expiratory pressure at the end of expiration (PEEP) greater than 12 cm H2O; escape around the orotracheal tube expressed by the difference between the inspired tidal volume and the expired tidal volume greater than 10%; presence of bronchopleural fistula; need to use other gases in the mixture such as nitric oxide and heliox; use of respirators with continuous flow; continuous hemodialysis and patients with pulmonary disease with chronic hypercapnia; presence of congenital heart disease; shock from other etiologies; liver cirrhosis, cancer; type I diabetes mellitus and autoimmune rheumatological diseases;  conditions that cause  microvascular derangements which may confound data analysis; indeterminate or unknown diagnosis time of septic shock; children whose parents or legal guardians did not agree or refused to sign the written informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-8xm896	Effect of a propolis tablet on the saliva and the amount of adolescent dental plaque microbes comparing with the use of another tablet without propolis	Data analysis completed	Intervention	2017-11-22	<NULL>	<NULL>	4568	Effect of a propolis-containing tablet on the acidity of saliva and the amount of adolescent dental plaque microbes: a randomized clinical study comparing with the use of another tablet without propolis, and without knowing who will ingest and supply the tablet	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8xm896	<NULL>	Individuals aged 10-19 years; both genders; individuals without cavitary caries lesions; healthy individuals without any systemic diseases.	Individuals intolerant to some component of the propolis-containing tablet; subjects undergoing antimicrobial treatment during the course of the study or for a period of 30 days prior to the study; individuals who used products containing xylitol up to 30 days before the start of study or during the course of the study; individuals who used products containing propolis up to 30 days before the start of the study or during the course of the study; individuals with orthodontic appliances; individuals who are using oral mouthwashes during the period of study; individuals with a history of intraoral surgery within the last 6 months; individuals who are making use of products rich in polyphenols: coffee, mate, acai, in the previous period (30 days) and during the research; individuals who consume alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-7n8y9ky	Effects of HIIT and Conventional Resistance Training on Maximal Strength and Muscle Hypertrophy	Data analysis completed	Intervention	2021-03-09	<NULL>	<NULL>	4570	Comparison effects of High Intensity Interval Training and Resistance Training on Maximal Strength and Muscle Hypertrophy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Centro Universitário da Serra Gaúcha	Centro Universitário da Serra Gaúcha	https://ensaiosclinicos.gov.br/rg/RBR-7n8y9ky	<NULL>	Healthy men; age between 18 and 35 years; Minimum experience of six months in strength training or running on a treadmill	Men with lower limb injuries; diagnosis of heart disease; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-4x9smr9	Estudo sobre a imagem corporal em jovens brasileiras	Data analysis completed	Intervention	2021-03-29	<NULL>	<NULL>	4589	Body Image among Brazilian adolescents: diagnosis and intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal de Juiz de Fora	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais - Campus Barbacena	https://ensaiosclinicos.gov.br/rg/RBR-4x9smr9	<NULL>	Young women, who are enrolled in technical and higher courses at the Federal Institute of Education, Science, and Technology of the Southeast of Minas Gerais - Campus Barbacena (IF Sudeste MG) and have no mental or eating disorders diagnosed and wish to participate voluntarily in the research.	Young people who report the presence of a diagnosed Mental or Eating Disorder will be excluded. Do not respond to the instruments in the follow-up period. Request the termination of your participation, through an express, free and clarified statement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-47kkgyk	Effect of 16 weeks of different training strategies on health status in individuals with Heart Failure	Data analysis completed	Intervention	2021-03-31	<NULL>	<NULL>	4593	"Analysis of the impact of different types of Physical Exercise on exercise tolerance and
quality of life in individuals with heart failure"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Instituto Estadual de Cardiologia Aloysio de Castro	Instituto Estadual de Cardiologia Aloysio de Castro	https://ensaiosclinicos.gov.br/rg/RBR-47kkgyk	<NULL>	Diagnosed with HF 1 year ago; any etiology; both sexes; older than 18 years; presenting an ejection fraction of less than 50%; clinically stable; no change in medications in the last 3 months.	Pregnancy and breastfeeding; presenting an injury that impairs the performance of the exercises; show signs of ischemia or major ECG abnormality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-10t84b5s	Clinical outcomes and costs of the use of Fibrin Glue in Pancreatic Surgery	Data analysis completed	Intervention	2021-04-05	<NULL>	<NULL>	4603	Impact of the use of Fibrin biological glue sealant on the reinforcement of Pancreatic anastomosis after Duodenopancreatectomy	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Hospital das Clínicas Faculdade de Medicina Ribeirão Preto	Hospital das Clínicas Faculdade de Medicina Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-10t84b5s	<NULL>	both sexes; any age; undergoing duodenopancreatectomy	There is not	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-46xb4bm	Polymer used in the Treatment of Stress Incontinence in Women.	Data analysis completed	Intervention	2021-04-05	<NULL>	<NULL>	4604	Polysacaride Gel for Treating Stress Urinary Incontinece in Women.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-46xb4bm	<NULL>	Female volunteers; diagnosis of stress urinary incontinence; no history of previous surgery.	Volunteers with previous diagnosis of infravesical obstruction of a mechanical nature; previous diagnosis of neurogenic bladder, presence of urethral hypermobility.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-6ybk8kr	Evaluation of two strategies for volume replacement in patients undergoing abdominal surgery	Data analysis completed	Intervention	2021-05-04	<NULL>	<NULL>	4616	Comparison between two strategies for perioperative volume replacement in abdominal surgeries: continuous infusion versus bolus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-05-31	Faculdade de Medicina de Botucatu UNESP	Faculdade de Medicina de Botucatu UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6ybk8kr	<NULL>	ASA I, II or III patients; Adults; Both sexes; Undergoing open abdominal surgeries; Minimum surgical duration of 120 minutes; Supine position during surgery; Undergoing general anesthesia	BMI greater than 35kg.m2; Gestation, chronic obstructive pulmonary disease or bronchial infection; Coagulopathies; Changes in preoperative renal function; Sepsis or SIRS; Hepatic insufficiency; Emergency or emergency surgeries; Refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-9cb3n9	Effect of consumption of juçara and açaí fruits on free radicals,total cholesterol, LDL, HDL, and triglycerides	Data analysis completed	Intervention	2019-06-07	<NULL>	<NULL>	4618	Effect of acute and long term consumption of juçara fruit (euterpe edulis) and açaí (euterpe oleracea) in antioxidant capacity, oxidative stress and metabolic parameters in healthy subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-9cb3n9	<NULL>	Age between 19 e 59 anos years; Body Mass Index (BMI) between 18.5 e 24.9 kg/m².	Not smoke; not drink alcohol regularly (maximum allowed 1 drink/week, e.g. 1 beer can or 150 mL of wine or 45 mL of distilled beverage); not use medicines or dietary supplements; not pregnant; no clinical condition as cardiovascular, endocrine, gastrointestinal, renal or hepatic diseases; no infections or inflammatory processes visible or, known three months prior to the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-54wq2nb	Effects of long jack suplementation on strength in weightlifing men	Data analysis completed	Intervention	2021-05-07	<NULL>	<NULL>	4626	Effects of Long Jack supplementation on strength in resistance trained man	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal de São Paulo campus Baixada Santista	Universidade Federal de São Paulo campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-54wq2nb	<NULL>	Healthy male individuals; 20-40 years old; practiced resistance training for at least 3 months non-interuptly.	participants will be excluded if they take some medication; sterois and supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-6jkg8s	At-home bleaching using prefilled whitening trays compared with fabricated trays	Data analysis completed	Intervention	2018-04-13	<NULL>	<NULL>	4628	At-home bleaching using prefilled whitening trays compared with fabricated trays: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista &quot;Julio de Mesquita Filho&quot;	"Instituto de Ciência e Tecnologia, Universidade Estadual Paulista ""Julio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-6jkg8s	<NULL>	Ages from 18 until 30 years old; good general health; do not present enamel erosion, dental abfraction, caries, periodontal disease or fluorosis ; do not use orthodontic appliance or removable prostheses; present all teeth - first molar to first molar (Upper and Lower); Avaiability of recurring returns; absence of gingival recession; teeth with A2 or darker color.	Chemically dependent patients, nonsmokers and alcoholic ; medical condition that may interefere in patients&apos; security during the study: use of drug therapy to chronic disease or allergic reaction to substances that will be used; pregnancy; participate of another study in the same time; pressenting restorations in the six anterior teeth of each arch; frequent use of fluoride supplementation or desensitization substances; bruxism; periapical lesions; tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-10nbmqm8	Tomographic and histological analysis of different approaches for closing the tooth extraction space: a study in humans	Data analysis completed	Intervention	2021-05-07	<NULL>	<NULL>	4631	Clinical and histological analysis of the socket sealing with Bio-Gide® versus Mucograft® of post-extraction sockets filled with Bio-Oss® Collagen: a study in humans	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2015-09-14	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10nbmqm8	<NULL>	18 years-old or above; at least 20 teeth in mouth; satisfactory oral hygiene (plaque index ≤ 25%); tooth with extraction indication in maxillary aesthetic zone (non-molar region); both adjacent teeth for interproximal bone crest maintenance; integrity of the alveolar bone around the tooth (no bone loss in any socket wall) assessed by cone beam computed tomography (CBCT) and confirmed by post-extraction clinical examination.	Smokers; patients with self-reported systemic conditions such as uncontrolled diabetes and pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-47n33tv	Treatment of knee osteoarthritis with electroacupuncture	Data analysis completed	Intervention	2021-05-10	<NULL>	<NULL>	4633	Eletroacupuncure in knee osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-15	Universidade Brasil	Centro de Especialidades e Reabilitação (CER) da Praia Grande- SP	https://ensaiosclinicos.gov.br/rg/RBR-47n33tv	<NULL>	The individuals included in study must have a diagnosis of bilateral knee Osteoarthritis documented, with or without indication of total knee prosthesis but who have not yet been prosthetic; aged 60 years or over and equal to or less than 80 years deity. Participating individuals must be able to walk (gait), with or without support, so that it is possible to carry out the physical tests relevant to the study.	Subjects who underwent acupuncture or physiotherapy treatment for the condition in question within less than 6 months;  undergoing drug treatment with steroidal or non-steroidal anti-inflammatory drugs. Patients with communication and comprehension disorders; insulin-dependent or non-insulin-dependent diabetics; illiterate individuals will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-67wxdw8	Effects of metformin during swimmer training performance	Data analysis completed	Intervention	2021-05-11	<NULL>	<NULL>	4638	Effects of metformin on training quality, performance and metabolic participation of swimmers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-15	Escola de Educação Física e Esporte de Ribeirão Preto	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-67wxdw8	<NULL>	The inclusion criteria include that the participant have experience in the sport for three years or more, participate regularly in competitions at the state or national level, have been training regularly for the past 2 years and present a medical certificate	Participants will be excluded who have type I or II diabetes mellitus, have some physical limitation, have kidney and / or liver problems or have pre-availability for such and have gastric discomfort after ingestion of the capsule.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-6m69fc	Therapeutic Pulmonary Telerehabilitation Protocol in patients affected by COVID-19, confined in their homes	Data analysis completed	Intervention	2020-04-02	<NULL>	<NULL>	4639	Therapeutic Pulmonary Telerehabilitation Protocol in patients affected by COVID-19, confined in their homes: Randomized Control Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-6m69fc	<NULL>	Patients between 18-75 years who are affected by coronavirus (COVID-19), and are in home confinement.	Patients with chronic lung conditions; Patients with chronic kidney disease; Patients affected with chronic neurological disorders; Patients suffering from hypertension and cardiovascular conditions without medical treatment; Patients affected with grade III osteoporosis; Patients affected with acute outbreaks of rheumatologic disorders; Patients affected with acute outbreaks disc abnormalities; Patients who have had respiratory conditions in the last 12 months; Patients who have recent musculoskeletal disorders, and who are not fully recovered from their injuries; Patients who have received physical therapy treatment in the last 3 months; Patients affected with chronic mental and / or psychological disturbances; Red Flags (Night pain, severe muscle spasm, loss of involuntary weight, symptom mismatch)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-668c8v	Comparison between High Intensity Interval Training and Strenght Training on Blood Vessel Health and Exercise Tolerance in Heart Failure	Data analysis completed	Intervention	2018-05-21	<NULL>	<NULL>	4640	Comparison  of High Intensity Interval Training versus Circuit Resistance Training on Endothelial Function and Oxygen Uptake Kinects in Heart Failure: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de Ceilândia da Universidade de Brasília	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-668c8v	<NULL>	Heart failure with reduced and preserved ejection fraction; both sexes; age greater than or equal to 35 years; sedentary in the last 6 months; non smokers. The regular medications accepted will only be used to control cardiovascular factors required by a cardiologist	Joint problems; respiratory diseases; inflammatory or infectious process; tendon or osteoarticular muscle injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-9458v9	Knee Osteoarthritis: Comparison between sensory motor training with sensory information and no additional sensory information	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	4642	Effect of sensory motor training with additional sensory information in women with knee osteoarthritis: A randomized blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-03	UFRN- FACISA	UFRN- FACISA	https://ensaiosclinicos.gov.br/rg/RBR-9458v9	<NULL>	Female individuals, BMI above 18.5; diagnosis of knee OA according to the American College of Rheumatology criteria; Mild or moderate OAJ according to the Lequèsne Algofunctional Questionnaire; Age over 60 years; knee stiffness for at least 6 months prior to screening; rigidity during the start of activities; individuals with no history of associated joint disease or systemic rheumatic disease and / or history of surgery on the affected lower limb; sedentary individuals; individuals without neurological, vestibular, visual or auditory deficits that make evaluations impossible.	Individuals with a bandage allergy or skin lesion in the region where the bandage will be applied; who have not completed the treatment period or who are unable to carry out the evaluation procedures correctly; volunteers who are absent more than twice during interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-6p32m3	Application of high frequency and microcurrent in the healing process of skin wounds	Data analysis completed	Intervention	2020-01-29	<NULL>	<NULL>	4647	High frequency and microcurrent efficacy in ulcer healing process: an experimental clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-10	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-6p32m3	<NULL>	carriers of ulcers; of both sexes; age between 18 and 90 years; residents in the municipality of Patos de Minas-MG; available for application of the procedures at the Physiotherapy Clinic of the University Center of Patos de Minas	pacemaker carriers, uncontrolled hypertension, osteomyelitis; pregnant women; individuals with necrosis or infected ulcers, using oral and topical healing drugs, mentally disabled; patients with a history of cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-6d88tdq	Study of effects of Laser on microorganisms and on success of canal treatment	Data analysis completed	Intervention	2021-05-21	<NULL>	<NULL>	4666	Study of effects of Laser on microorganisms and on success of canal treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Universidade Federal do Rio de Janeiro - Instituto de microbiologia Paulo de Góes	Universidade Federal do Rio de Janeiro - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-6d88tdq	<NULL>	First and second mandibular molars; diagnosis of necrosis with periapical lesion; completely closed apices; in need of endodontic treatment; patient between 18 and 80 years old; patients with painful symptoms.	Patients who used antibiotics, immunosuppressive and anti-inflammatory drugs in the last three months; teeth with root fractures, previous endodontic treatment, periodontal pocket, anatomical complexities, coronary fracture or very extensive cavities; pregnant and lactating patients; patients with systemic and oral cavity diseases that could influence the natural course or treatment of the disease; patients with systemic conditions that need prophylactic antibiotic coverage; patients who did not agree to participate or sign the IC.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-32jjn36	Impact of physical exercise on obesity and overweight among adolescents living in rural areas	Data analysis completed	Intervention	2021-05-25	<NULL>	<NULL>	4669	Effects of a physical exercise program on obesity and overweight in rural schoolchildren	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-11	Escola Paulista de Enfermagem/ Universidade Federal de São Paulo	Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq	https://ensaiosclinicos.gov.br/rg/RBR-32jjn36	<NULL>	Students aged between 14 and 18 years; overweight or obese; who were authorized by the doctor to perform physical activity; and who did not have physical mobility problems and/or cognitive alterations	Adolescents who did not perform outcome assessments before and after the intervention; or those who did not attend physical exercise sessions for a week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-2v2mwkz	The influence of twin pregnancy on the kinetic disposition and crossing of the placental barrier of betamethasone	Data analysis completed	Observational	2021-02-10	<NULL>	<NULL>	4670	Pharmacokinetics and placental transfer studies of betamethasone in twin pregnancies	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2018-03-31	Faculdade de Medicina de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2v2mwkz	<NULL>	Adult women (&gt; 18 years) with single or multiple pregnancies of morphologically normal fetuses, with gestational age between 24 - 34 weeks; risk of imminent prematurity and therefore, with an indication of antenatal administration of betamethasone to stimulate fetal maturity; normal biochemical and hematological parameters.	Smoking, alcoholism, and/or use of illegal substances; maternal diseases that develop vasculopathy and influence uteroplacental flow, such as hypertension, uncontrolled diabetes, heart disease, kidney disease, or thrombophilia; fetuses with congenital anomaly; injury identification in target organs by laboratory examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-2ksw7mc	Mindfulness-complementary intervention in assisting the elderly with depressive symptoms	Data analysis completed	Intervention	2021-05-27	<NULL>	<NULL>	4681	Mindfulness-complementary intervention in assisting the elderly with depressive symptoms	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-23	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2ksw7mc	<NULL>	"Elderly aged 60 and over
Seniors of both sexes UNAMI students;
Elderly men and women who participate in CRAS activities.
Elderly men and women interested in the study after disclosure of UEMS;"	"Elderly people with inability to communicate and / or autonomy to respond;
With cognitive deficit, mental illnesses mainly schizophrenia, epilepsy;
Elderly people who use antidepressants (for directly interfering with the outcome of interventions)
Elderly people who are already practicing (at least once a week) yoga and meditation.
3 or more absences in mindfulness practices"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-6c4c6hk	Adverse events evaluation of vaccine against diphtheria, tetanus and whooping cough in children in the city of Goiania - Goias	Data analysis completed	Intervention	2021-05-28	<NULL>	<NULL>	4693	Evaluation of reactogenicity of vaccine in infants tetravalent Goiânia - Go	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-12	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6c4c6hk	<NULL>	Child must be a resident of the city of Goiânia, Goiás; A legal guardian must be present; Belonging to the age group between 2-12 months; There have been exposed to some intramuscular injection in the last 3 days; It is only vaccinated with the vaccine Serum laboratory.	Weight less than three kilograms; Ggestation than 37 weeks; children vaccinated with the vaccine laboratory Bern.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-6dshhhp	Use of photobiomodulation, with laser and LED, in people with knee pain due to patellofemoral syndrome	Data analysis completed	Intervention	2021-05-29	<NULL>	<NULL>	4698	Analysis of trunk muscle activity and hip and knee proprioception in women with Femoropatellar Pain.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-6dshhhp	<NULL>	Pain in the anterior region of the knee with a score higher than 3 on the Visual Analogue Pain Scale (VAS). Positive result on the McConnel test and a Clarke&apos;s sign.	Other dysfunctions related to the knee joint. Undergoing treatment for the syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:34
RBR-22p3nn2	Mindful Eating in the treatment of Obesity	Data analysis completed	Intervention	2021-05-31	<NULL>	<NULL>	4703	Mindful Eating in the treatment of Obesity - ATENTO study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-11	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-22p3nn2	<NULL>	Women between the ages of 18 and 50 with a BMI between 30 and 39.9kg/m2.	Male gender; age over 50 or under 18; pregnancy; lactation; menopause; iliterate individuals; individuals not adhering to the project proposal; undergoing bariatric surgery or already on a weight loss program; endocrine diseases; genetic diseases; heart disease; nephropathy; liver disease; use of medications that cause weight gain; cognitive deficit; active psychiatric illness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:34
RBR-88z25c5	Heart Analysis of the Individuals with Super Mobility	Data analysis completed	Intervention	2021-05-31	<NULL>	<NULL>	4704	Analysis of Heart Rate Variability by the Wavelet method in individuals with Joint Hypermobility submitted to the use of Eicmer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade do Vale do Paraíba	Universidade do Vale do Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-88z25c5	<NULL>	Women with myofascial trigger point in the upper trapezius muscles; non history of cardiovascular disease (congenital or acquired in order); patients with general joint hypermobility in the Beighton’s criteria; patients with joint hypermobility syndrome in the Brighton’s criteria; women during the luteal phase of menstrual cycle.	Patients with central nervous system deficits; patients with cognitive deficits; patients receiving treatment by other methods like vapocoolants, dry needling, acupuncture injections etc; patients with myofascial trigger points in muscles other than muscle trapezius; history of cardiovascular disease (congenital or acquired), diabetes, respiratory disorders or metabolic diseases; users of hormonal medication; diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-10ntyj94	Analgesic blockade of the nerves responsible for  innervation of the hip for analgesia in the elderly with hip fracture before spinal anesthesia	Data analysis completed	Intervention	2021-06-01	<NULL>	<NULL>	4715	Pericapsular nerve group block preceding spinal anesthesia in elderly people with hip fractures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-16	Insttituto DR José Frota	Insttituto DR José Frota	https://ensaiosclinicos.gov.br/rg/RBR-10ntyj94	<NULL>	over 60 years old age; both genders; physical status ASA II and ASA III; with transtrochanteric;  subtrochanteric;  acetabular and femoral fractures	Hypersensitivity  to any of the drugs used in the study; need to use vasoactive drugs; ventilatory support; decompensated diabetes mellitus; severe arterial hypertension; previous or current coronary artery disease; previous or current stroke; blockade advanced cardiac; severe left ventricular dysfunction; renal or hepatic failure; intracranial hypertension; severe head trauma; glaucoma; psychiatric illness;  illicit drugs users; patients who could not collaborate with the postoperative evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-9wzwv5	Comparison of Costoclavicular block with Supraclavicular and Axillary block for Upper Limb Surgery: A Randomized Trial	Data analysis completed	Intervention	2019-10-21	<NULL>	<NULL>	4721	Efficacy of surgical analgesia of Costoclavicular block in comparison to Supraclavicular and Axillary blockade, guided by ultrasonography, for procedures distal to the elbow: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Hospital das Clínicas da Universidade Federal de Uberlândia	Hospital das Clínicas da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9wzwv5	<NULL>	Participants undergoing elective and urgent elbow, forearm, wrist and hand surgeries; both genres; aged 18 to 70 years; ASA I to III classification; BMI between 18 and 30	participant&apos;s refusal; classification of physical status ASA greater than III; inability to consent; coagulopathy; sepsis; pregnancy; neuromuscular disease; allergy to local anesthetics; neuropathy or previous deficit of musculocutaneous / radial / ulnar / median; previous surgery in the infraclavicular fossa; infection at the needle insertion site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-94qz3ym	Study of infected hip and knee joint prostheses using the sonication technique	Data analysis completed	Observational	2021-02-12	<NULL>	<NULL>	4728	Epidemiological and microbiological study of hip and knee infected arthroplasties using the sonication technique	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-09-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94qz3ym	<NULL>	All patients who underwent total and partial hip and knee arthroplasties, with the implant removed for sonication.	Absence of collection of peri-prosthetic tissue in the intraoperative moment; Obvious contamination of orthopedic implants during their removal and/ or transport; Patients whose arthroplasties were not submitted to sonication due to the unavailability of suitable containers for transporting the implant at the time of removal or the absence of containers in the institution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-8y3mrwg	Blood Pressure Reduction after Blood Flow Restriction Training	Data analysis completed	Intervention	2021-06-07	<NULL>	<NULL>	4729	Acute Effect of Blood Flow Restriction Strength Exercise on Blood Pressure in Women with Type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Ciências Sociais Aplicadas	Faculdade de Ciências Sociais Aplicadas	https://ensaiosclinicos.gov.br/rg/RBR-8y3mrwg	<NULL>	Female volunteers; age between 18 and 60 years; medical diagnosis of type II diabetes; not participating in systematic physical training programs.	Use of insulin, metformin and beta blockers during the study period; Lesão osteomioarticular que impossibilite a realização das condições de exercício propostas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-5w39snn	Effectiveness of Pilates exercises in the treatment of chronic low back pain	Data analysis completed	Intervention	2021-06-08	<NULL>	<NULL>	4734	Effectiveness of Pilates method in the treatment of nonspecific chronic low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Pontifícia Universidade Católica de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5w39snn	<NULL>	Individuals aged between 18 and 60 years who had NSCLBP lasting for more than 3 months.	Autoimmune rheumatic and inflammatory diseases, lower extremity radiating pain, fibromyalgia, thyroid disease, pregnancy, neurological or cognitive diseases, morbid obesity, lower limb amputees, patients with uncontrolled disease (e.g. hypertension or heart disease)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-3yfhyby	Manual therapy for headache in university students	Data analysis completed	Intervention	2021-06-08	<NULL>	<NULL>	4735	Manual therapy in episodic tension headache in university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Fundação Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3yfhyby	<NULL>	University students aged between 18 and 30 years; with headache for more than 3 months; with episodic tension headache confirmed by responses to questionnaire 1; not using painkillers; agree to participate in the research through the Informed Consent Form.	Impossibility of carrying out the care protocol; using analgesic drugs during the study period and applying the protocol; missing more than 2 visits; and, withdrawing consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-105nyj86	A study of a new primaquine 5 mg formulation in healthy volunteers	Data analysis completed	Intervention	2021-06-09	<NULL>	<NULL>	4736	Bioavailability study of two formulations of Primaquine	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-07-21	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-105nyj86	<NULL>	"Men,
Non-pregnant and non-breastfeeding women
Within the age range 18 to 50 years old
Body Mass index range 19 to 28,5 Kg/m2
Health volunteers
Signed Informed Consent"	"Hypersensibility to the drug (primaquine): Previous pathologies that could influence the absorption distribution or excretion of the drug; Positive G6PD deficiency quantitative or pregnancy test.  Use o concomitant medicines; Any clinical or laboratory exam abnormality;
Smokers; heavy coffee drinkers (&gt;5 cups/Day); Abusive alcohol use: use of any treatment within 2 weeks before the study;Any previous hospitalization with 8 weeks before the study: Any previous treatment with known drug interaction with the test drug within 03 months; Blood donation greater than 450ml 03 months prior the study, or 1500ml in the previous 12 months; Use of Cyp 450 Inductors medications 4 weeks prior; Consume of alcohol or grapefruit 48h prior hospitalization;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-6vmmhfp	Attention training to improve school performance in autism	Data analysis completed	Intervention	2021-06-09	<NULL>	<NULL>	4740	"Evaluation of a Computerized Attention Training program to improve
academic performance in children with Autism Spectrum Disorder"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Centro de Atenção Integrada à Saúde Mental (CAISM) da Santa Casa de São Paulo	Universidade Presbiteriana Mackenzie	https://ensaiosclinicos.gov.br/rg/RBR-6vmmhfp	<NULL>	A diagnosis of Autism Spectrum Disorder; between 8 and 14 years old; both genders; patients from the reference unit for autism from Santa Casa of São Paulo; no severe behavioral problems	Severe behavior problems that make data collection unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-7hsjfjk	Changes in body fat and muscle mass in overweight adolescents and genetic predisposition to obesity, submitted to different physical exercise programs	Data analysis completed	Intervention	2021-06-17	<NULL>	<NULL>	4753	"Body composition and Genetic assessments in Overweight adolescents and young people
and Obese, submitted to different Physical Activity Programs"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal de São João del Rei	Universidade Federal de São João del Rei	https://ensaiosclinicos.gov.br/rg/RBR-7hsjfjk	<NULL>	Adolescents characterized as overweight and obese, aged between 15 to 19 years old, enrolled in the state public school system, in morning, afternoon or night shifts; agree to participate in the study, by presenting a Free and Informed Consent Form (TCLE) signed by parents and / or guardians (when minors) or by the volunteer (when over 18); underage individuals should sign the Informed Consent Form.	Unavailability to participate in evaluations or unable to attend School Physical Education classes; presentation of an injury picture (before or during the intervention program) that would permanently disable them to practice the exercises; maximum limit of 20% of consecutive absences in the intervention program; unavailability to participate in the stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-9m3jy47	Test of the effect of Pulsed Light in the treatment of Dry eye	Data analysis completed	Intervention	2021-06-22	<NULL>	<NULL>	4760	Evaluation of the effectiveness of Pulsed Light in the treatment of Evaporative dry eye	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-28	Bernardo Reichert	Hospital de Olhos do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9m3jy47	<NULL>	To be literate (to be able to read and sign the informed consent form); to be of legal age; to be able to follow the treatment schedule and to follow their requirements; to have a BUT equal to or less than 7.	Those who did not completed all treatment; they did not want to participate in the study anymore; they had an infection during treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-107hzdqt	Educational practice to encourage teenagers to vaccinate against HPV	Data analysis completed	Intervention	2021-06-23	<NULL>	<NULL>	4761	Educational intervention for adherence of adolescents to vaccination against Human Papilloma Virus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-107hzdqt	<NULL>	School girls aged nine to 14 years who did not have doses of HPV vaccine, as evidenced by the vaccination card.	Physical condition that made it impossible to respond directly to the data collection instrument.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-87kphy	Evaluation of a new substance (isobutylamido thiazolyl resorcinolcream) compared to the use of hydroquinone 4% cream to treat facial blemishes	Data analysis completed	Intervention	2020-10-09	<NULL>	<NULL>	4783	Efficacy and safety of topical 0,2% Thiamidol versus 4% Hydroquinone in the treatment of facial Melasma in women: a randomized and evaluator blinded clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-13	Faculdade de Medicina de Botucatu (FMB - Unesp)	Escola Paulista de Medicina (EPM/UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-87kphy	<NULL>	Women with facial melasma 18 to 50 years old, Fitzpatrick&apos;s phototypes II to V.	Pregnant and lactating women; women with vitiligo or photosensitizing diseases; individuals who are using other whitening substances and those who refuse to be photographed; photoexposed women and menopausal women (after 50 years).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:40
RBR-7mwjzwb	Effects of Muscle Trigger Point Dry Needling Therapy in Patients with Jaw Pain	Data analysis completed	Intervention	2021-07-14	<NULL>	<NULL>	4788	Effects of Myofascial Trigger Point Dry Needling Therapy in Patients with Temporomandibular Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7mwjzwb	<NULL>	Temporomandibular disorder; myofascial trigger point in the masseter muscle; age between 18 and 40 years; both genders.	Pregnant women; vascular diseases; blood dyscrasias; trigeminal neuralgia; fibromyalgia; history of odontogenic infection in the last 30 days; current or past history of neoplasia or radiotherapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:40
RBR-8jyhxh	Clinical trial for the treatment of COVID-19 with Chloroquine and Colchicine	Data analysis completed	Intervention	2020-07-30	<NULL>	<NULL>	4807	Randomized clinical trial for the treatment of moderate to severe cases of COVID-19 with Chloroquine and Colchicine	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-04-11	Hospital das Clínicas de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8jyhxh	<NULL>	Moderate or severe forms of COVID-19; 18 years or older; body weight of 50 kg or more; serum Ca2+ and K+ normal; QT interval lower than 450 ms at 12 derivations electrocardiogram; beta-HCG (serum or urine) negative (if woman under 50).	Mild and critical forms of COVID-19; allergy to any of the medications under study; diagnosis of porphyria, myasthenia gravis or uncontrolled arrhythmia at admission; pregnancy; use of digoxin, amiodarone, verapamil or metoprolol; use of protease inhibitors; history of chronic liver disease with liver dysfunction; unable to understand the information contained in the Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-99tc3s2	Impact of social distance measures from COVID-19 pandemic on elderly dental assistance and mental health.	Data analysis completed	Observational	2021-07-31	<NULL>	<NULL>	4808	Impact of social distancing measures resulting from the severe acute respiratory syndrome coronavirus 2 (SARS COV-2) pandemic on the mental health, sleep quality, and dental needs of elderly individuals.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	Faculdade de Odontologia de Piracicaba (Fop/Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-99tc3s2	<NULL>	Aged 60 years or older. Being Brazilian. Having internet access.	Elderly without internet access. Elderly unable to fully respond to survey instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-5ch9crp	Effect of Magnesium Sulfate added to local anesthetic in the anesthesia for the arm	Data analysis completed	Intervention	2021-08-04	<NULL>	<NULL>	4813	Magnesium Sulfate as adjunvant to Bupivacaine in Supraclavicular Brachial Plexus Block: is it effective? - a randomized double-blind clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-12-21	Fundacao do ABC	Fundacao do ABC	https://ensaiosclinicos.gov.br/rg/RBR-5ch9crp	<NULL>	Patients with ASA classification PS1 and PS2; over 18 years of age; submitted to upper limb surgery with indication of supraclavicular brachial plexus block	presença de lesão de nervo periférico; doença cardíaca, hepática ou renal; vigência de tratamento com bloqueador de canal de cálcio; presença de distúrbios de coagulação ou uso de anticoagulantes; presença de infecção no local de punção; uso prévio de opioides; dificuldade para compreender a EVA (Escala Visual Analógica); alergia a anestésicos locais ou sulfato de magnésio; gestação;  peso corporal inferior a 40kg; falha total ou parcial do bloqueio sensitivo 35 minutos após a injeção; pósoperatório em unidade de terapia intensiva; necessidade intraoperatória de mudança da técnica anestésica devido a falha do plano anestésico	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-4pdt45s	Oral health, bite force and chewing ability in people with complete dentures e and with implants of the diferent attachments	Data analysis completed	Intervention	2021-08-05	<NULL>	<NULL>	4818	"Effect of rehabilitation with mandibular overdenture on self-perceived health
mouthwash, masticatory efficiency and maximum bite force in users of complete dentures"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-15	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4pdt45s	<NULL>	Age over 60 years old; Class I intermaxillary relationship; little or moderate alveolar bone resorption; edentulous; normal neuromuscular control; edges of medium size and resilience.	Class II or III types intermaxillary relationship; neuromuscular dysfunction; psychic problems; xerostomia; the presence of oral pathologies; severe bone resorption.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-439f77	Behavioral intervention about adherence to oral antidiabetic to treatment of diabetes mellitus	Data analysis completed	Intervention	2016-01-12	<NULL>	<NULL>	4826	Effect of strategies &quot;action planning and coping planning&quot; about adherence to oral antidiabetic agents: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-11	Faculdade de Enfermagem da Universidade Estadual de Campinas - Unicamp	Faculdade de Enfermagem da Universidade Estadual de Campinas - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-439f77	<NULL>	Patients of both genders with diabetes mellitus,type 2; adults over 18 years; continuous use for at least six months of oral antidiabetic agents; show an average score intention greater than or equal to 4.	Drug administration by a caregiver; use insulin to treat diabetes mellitus; make diabetes monitoring in other health service.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-8d9hxj	Effect of carbohydrate-rich solutions on gastric emptying in children	Data analysis completed	Intervention	2019-11-13	<NULL>	<NULL>	4828	"Mother project: &quot;Effect of administering different carbohydrate-rich solutions on gastric emptying in pediatric patients: Randomized controlled trial&quot;

Subproject I: &quot;Ultrasound evaluation of gastric volume in children undergoing upper digestive endoscopy after ingestion of different carbohydrate-enriched solutions compared with fasting pediatric patients: a randomized controlled trial&quot;

Subproject II: &quot;Effects of the administration of different carbohydrate-rich solutions on ga"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-29	Faculdade de Medicina de Botucatu da Universidade Estadual Júlio de Mesquita Filho	Faculdade de Medicina de Botucatu da Universidade Estadual Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-8d9hxj	<NULL>	Age between 3 and 15 years; elective upper digestive endoscopy; written authorization from parents or legal representatives through the Free and Informed Consent Form, in the case of children aged 3 to 12 years; over 12 years old, authorization by an Informed Consent Form.	Use of nasoenteric tube; Unstable clinical situation; Presence of encephalopathies; History of gastroparesis; History of recent upper gastrointestinal bleeding (more than 1 month); Previous surgery of distal stomach or esophagus; Vomiting after solution consumption; Children whose parents or legal guardians do not agree to participate; Non-aspirable intra-gastric content	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-7dq3v7b	Effects of maternal obesity on the kinetic disposition of misoprostol during labor induction	Data analysis completed	Observational	2021-08-13	<NULL>	<NULL>	4834	Effects of maternal obesity on the pharmacokinetics of misoprostol during labor induction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2015-05-25	Faculdade de Medicina de Ribeirão Preto	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7dq3v7b	<NULL>	Parturients (&gt; 18 years old); single pregnancy; BMI characterized as: not obese, obese grade 1, obese grade 2 and morbid obesity; without fetal complications; hospitalized for induction of labor with misoprostol 25ug vaginally.	patients with renal failure and chronic liver diseases (identified by laboratory tests); congestive heart failure; patients who suffered a heart attack or stroke less than six months ago; patients with a history of severe chronic obstructive pulmonary disease; parturients who used inducers or inhibitors CYP; previous cesarean section	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-62qgf6	Use of methods to avoid pregnancy in women with sickle cell disease	Data analysis completed	Intervention	2018-03-15	<NULL>	<NULL>	4839	Contraception in women with Sicle Cell Disease: a cohort study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-03	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-62qgf6	<NULL>	Women with Sicle Cell Disease; Age between fifteen and forty years; Woman with sexual activity; Desire for contraception	Women with difficulty understanding the questions included in the questionnaire at the initial moment of the research; Women who have the HbSC genotype; Women using prophylactic continuous blood transfusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-677rt3	Identification of frail elderly people through an algorithm and mobile application by physical therapists	Data analysis completed	Observational	2019-09-20	<NULL>	<NULL>	4844	Safety practices for physical therapists in the guidance of the elderly: mobile app	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-21	Universidade do Vale do Sapucaí - UNIVAS	Universidade do Vale do Sapucaí - UNIVAS	https://ensaiosclinicos.gov.br/rg/RBR-677rt3	<NULL>	Senior citizens aged 60 years or over; all genres; cooperative; who wander even with the help of orthoses and prostheses; who agree to participate in the study; and sign the TCLE (elderly or responsible)	"Elderly people with severe cognitive impairment that impedes the understanding of the tests to be performed; with immobility syndrome; is that
conditions which make it impossible for them to the performance of the proposed procedures; and those who desist from continuing in the study after signing the TCLE"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-5m5qg83	Effect of nursing consultation based on the supported self-care technique on treatment adherence of patients with high blood pressure	Data analysis completed	Intervention	2021-08-20	<NULL>	<NULL>	4845	Effect of nursing consultation based on self-supported care on therapeutic adherence of hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Universidade de Pernambuco	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5m5qg83	<NULL>	Age 18 years or older; confirmed medical diagnosis of arterial hypertension; antihypertensive treatment for at least six months; monitoring with a professional nurse in the ESF, residing in the coverage area of ​​the selected health units.	People with cognitive impairment to answer questionnaires about aspects of memory, attention and communication skills; pregnant women with hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-2b2vvf5	Caries prevention around the orthodontic appliance	Data analysis completed	Intervention	2021-08-23	<NULL>	<NULL>	4847	Effect of using low-viscosity resinous infiltrant (Icon®) to prevent carious lesions around orthodontic brackets: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	São Leopoldo Mandic	São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-2b2vvf5	<NULL>	Age between 12 and 20 years; incisors, canines and premolars present in the arch, all with a healthy buccal surface at the beginning of orthodontic treatment; ICDAS greater than 2; no history of previous orthodontic treatment.	Abuse of any type of medication, alcohol, nicotine or other types of drugs; systemic, metabolic or mental illness; craniofacial syndrome, cleft lip and / or palate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-9hnftg	Effect of a chitosan-chamomilla microparticle formulation in the prevention of radiation dermatitis	Data analysis completed	Intervention	2019-08-26	<NULL>	<NULL>	4848	Effect of a chitosan-chamomilla microparticle formulation in the prevention of radiation dermatitis: a randomized controlled phase II clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2019-01-23	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9hnftg	<NULL>	18 years older; confirmed diagnosis of breast cancer; indication of radiotherapy treatment; Not having started radiation therapy; non-history of allergic reactions to any other component of chamomile or lanolin; non-history of allergic reactions to fish, shrimp or seafood; Kanofsky greater than 70; No use of systemic corticosteroids. do not use heparin, oral anticoagulants and antiplatelet agents.	Present any injury at the treatment site; present skin involvement by the tumor;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-3fv39rm	Study of the Effectiveness of Preoperative Gabapentin in the Control of Postoperative Pain in Patients Undergoing Inguinal Hernia under Spinal Anesthesia	Data analysis completed	Intervention	2021-08-24	<NULL>	<NULL>	4849	Study of the Effectiveness of Preoperative Gabapentin in the Control of Postoperative Pain in Patients Undergoing Inguinal Hernia under Spinal Anesthesia	<NULL>	1, non-randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-09-10	santa casa de misericordia	santa casa de misericordia	https://ensaiosclinicos.gov.br/rg/RBR-3fv39rm	<NULL>	Both genders; age between 18 and 60 years; Maximum BMI of 30; scheduled for inguinal hernioplasty at Hospital São José do Avaí.	Patients with chronic opioid use; patients with chronic pain; history of chemical dependency; or those allergic to any of the medications used in the study; cardiac respiratory renal or hepatic pathology; BMI above 30 kg /m2; relapsed hernias and inguino-scrotal hernias.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-8dfz66h	Evaluation of the effects after using different mouthwashes	Data analysis completed	Intervention	2021-09-03	<NULL>	<NULL>	4861	Evaluation of the effects of 0.12% chlorexidine and blue®m mouthwash in patients with gingivitis	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2019-03-01	Fundação de Assistência e Educação - FAESA	Fundação de Assistência e Educação - FAESA	https://ensaiosclinicos.gov.br/rg/RBR-8dfz66h	<NULL>	Present more than 24 teeth and generalized gingivitis; Absence of periodontal pockets with depth greater than 4mm; No interproximal loss greater than 2mm.	Use of orthodontic appliance; Treatment of antibiotics in the last 3 months; Smokers, pregnant and nursing women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-4t22trj	Pharmacotherapeutic follow-up of patients using anticoagulant medication in primary care.	Data analysis completed	Intervention	2021-09-06	<NULL>	<NULL>	4862	Evaluation of the effectiveness of a protocol for Anticoagulated patients in the public health system in the city of Ijuí / RS	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-4t22trj	<NULL>	patients using warfarin for chronic diseases, residing in the urban area of ??the city of Ijuí / RS, having consulted in a Health Unit in the city.	patients residing in the rural area of ??the municipality (due to the logistics for monitoring), those who stopped using warfarin before the first interview, and who did not agree to sign the informed consent form and participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-4bcp54k	Effect of treatment with whole Grape Juice along with traditional treatment in patients hospitalized with covid19	Data analysis completed	Intervention	2021-09-06	<NULL>	<NULL>	4863	Evaluation of Grape Juice treatment on Systemic Inflammation, Oxidative Stress, Autonomic Neuromodulation and the impacts of these variables on the severity of progression of Covid19 (2019 coronavirus disease) in hospitalized patients	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-10-20	Empresa Brasileira de Serviços Hospitalares	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4bcp54k	<NULL>	Volunteers of both sexes over 18 years of age who had confirmed COVID-19 disease between October 20, 2020 and February 28, 2021, and who were functionally able to ingest food, in addition to agreeing to participate in the study by signing the Informed Consent Form	Patients who had difficulties in ingesting food during the study, died and/or did not undergo the final tests at hospital discharge, in addition to medical recommendations not to ingest the drink, were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-9h9c32b	Comparison of different approaches for wisdom tooth extraction	Data analysis completed	Intervention	2021-09-09	<NULL>	<NULL>	4875	Comparison of different approaches - flap designs - in the postoperative of impacted third molar surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9h9c32b	<NULL>	The patient must be aged between 18 and 40 years, have both impacted mandibular third molars with similar positions and angulation, present periodontal health and have the availability of a preoperative panoramic radiograph.	Patients with systemic desabilitation, smokers or using medications that could influence the surgical procedure or postoperative healing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-10cdw3ph	Influence of prosthesis types on mastication quality and oral health-related quality of life	Data analysis completed	Observational	2021-09-13	<NULL>	<NULL>	4880	Influence of prosthesis types on masticatory efficiency and oral health-related quality of life	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2015-05-09	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10cdw3ph	<NULL>	Present over 18 and under 80 years; use total prosthesis in both arches; use partial removable prosthesis in at least one arch; have at least 20 working teeth	Xerostomia; periodontal disease; motor or psychological or cognitive disorders; communication difficulties; malnutrition; disorders of the temporomandibular joint; orthodontic appliance users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-7jh3jpw	Nutritional status of vitamins and minerals in individuals with Severe Obesity undergoing Stomach Reduction Surgery	Data analysis completed	Intervention	2021-09-13	<NULL>	<NULL>	4882	Nutritional status of micronutrients in individuals with Morbid Obesity undergoing Roux-and-Y Gastric Bypass Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-18	Universidade Federal do Rio de Janeiro	Centro Multidisciplinar de Cirurgia Bariátrica e Metabólica	https://ensaiosclinicos.gov.br/rg/RBR-7jh3jpw	<NULL>	Patients who underwent bariatric surgery using Roux-en-Y gastric bypass (RYGB); BMI higher or equal to 35 kg/m2; aged between 20 and 60 years and serum biochemistry outcomes collected before their scheduled RYGB.	Previous bariatric, disabsortive or restrictive gastrointestinal surgeries; immunosuppressive therapy use; pregnant or planning a pregnancy in the next 6 months; lactation; smoking; cancer and intestinal disabsortive syndromes diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-54sttfk	The effectiveness of tele-rehabilitation for individuals with Parkinson&apos;s disease	Data analysis completed	Observational	2021-09-14	<NULL>	<NULL>	4886	The impact of tele-rehabilitation on motor signs, freezing of gait and quality of life of individuals with Parkinson&apos;s disease during the social distancing due to pandemic	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade de São Paulo	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-54sttfk	<NULL>	"Have a clinical diagnosis of Parkinson&apos;s Disease; be between 35 and 90 years of age;
be doing social distancing during the COVID-19 pandemic since March 24, 2020, where the COVID cases started; not having dementia; not having severe depression; not having severe hearing and visual problems that make it impossible to perform the telerehabilitation; having started telerehabilitation in April 2020 at Associação Brasil Parkinson; agree with the Informed Consent Form"	Not being a member of the Brasil Parkinson Association; be under 35 years of age and over 90 years of age; failure to socialize during the COVID-19 pandemic; have severe dementia and depression; not having started telerehabilitation in April at Associação Brasil Parkinson	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-9cht5w7	Nutrition intervention based on behavior change theories in overweight non-dialysis dependent chronic kidney disease women	Data analysis completed	Intervention	2021-09-15	<NULL>	<NULL>	4888	Nutrition intervention based on behavior change theories in overweight non-dialysis dependent chronic kidney disease women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade Federal de São Paulo	Fundação Oswaldo Ramos/Hospital do Rim	https://ensaiosclinicos.gov.br/rg/RBR-9cht5w7	<NULL>	Women aged 25 to 75 years  body mass index greater than or equal to 27 kg / m²; Estimated Glomerular Filtration Rate between 15 to 45 ml / min / 1.73m²; who have had at least three previous medical appointments and at least two previous dietitian appointments.	Illiterate patients with cognitive or visual impairment, terminal cancer, acquired immunodeficiency syndrome (AIDS), on steroids, pregnant women, severe psychiatric disorders and autoimmune diseases will be considered ineligible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-3vn9c5q	Autogenous Bone Block versus Collagenated Xenogeneic Bone Block to evaluate treatment concept for reconstruction of atrophic alveolar ridge: a non-inferiority randomized clinical trial	Data analysis completed	Intervention	2021-09-16	<NULL>	<NULL>	4894	Randomized controlled clinical trial to evaluate the concept of treatment for atrophied alveolar ridge reconstruction using Collaged Xenogenic Bone Block (CXBB) versus Autogenous Bone Block (ABB) treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Faculdade de Odontologia da Universidade de São Paulo	Geistlich Pharma AG	https://ensaiosclinicos.gov.br/rg/RBR-3vn9c5q	<NULL>	Written informed consent; Age 18 years or older; Partial edentulism (up to 4 missing adjacent teeth); Atrophied alveolar ridge with one or more adjacent missing teeth; Atrophied alveolar ridge with residual ridge width of ≤ 4 mm; Sufficient bone height at the surgical site for implant placement	General contraindications for dental and/or surgical treatments; Periodontitis or Peri-implantitis; Probing depth &gt; 4mm at the adjacent teeth; Inadequate oral hygiene (PI&gt;1); Knife-edge morphology of the alveolar ridge; Implants adjacent to the surgical site; Inflammatory disease of oral cavity; Immunological impairment; Allergy to collagen; Diabetes; History of myeloma, respiratory tract cancer, breast cancer, prostate cancer or kidney cancer requiring chemotherapy or radiotherapy within the past five years; Previous, concurrent or planned radiotherapy of head area; Concurrent or previous immunosuppressant, bisphosphonate, high-dose or long-term corticosteroid therapy; Smokers or subjects who did not quit smoking at least 3 months prior to the surgery; Pregnant or lactating women; Women of childbearing age, who are not using a highly effective method of birth control; Participation in an investigational device, drug or biologics study within the last 26 weeks prior to the study start; Participation in any other clinical investigation during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-5yrjrr4	Effect of zinc supplementation in patients with ulcerative colitis	Data analysis completed	Intervention	2021-09-17	<NULL>	<NULL>	4898	Effect of zinc supplementation on inflammatory markers in ulcerative colitis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	REGINA MÁRCIA SOARES CAVALCANTE	UNIVERSIDADE FEDERAL DO PIAUÍ	https://ensaiosclinicos.gov.br/rg/RBR-5yrjrr4	<NULL>	Patients diagnosed with ulcerative colitis (with at least 6 months of diagnosis time);non-smokers; without coexisting pathologies such as diabetes; hypertension and kidney disease;cardiovascular diseases; rheumatic diseases and any other diseases involving an inflammatory process; without the use of a vitamin-mineral supplement;  who voluntarily agreed to participate in the research, with the consent materialized by signing the Informed Consent Term.	Patients who changed city and/or state; who did not have telephone contact;who discontinued use of the supplement; who did not attend the collection of biological material	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-10jyygyg	Evaluation of the Effectiveness of the Application of Argon Gas and / or Metal Clip for the treatment of patients who Regained Weight in the postoperative period of Stomach Reduction Surgery	Data analysis completed	Intervention	2021-09-22	<NULL>	<NULL>	4911	Endoscopic Profile and Application of Argon Plasma and / or Metal Clip in patients undergoing Gastric Bypass after Weight Regain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de Medicina de São Jose do Rio Preto	Faculdade de Medicina de São Jose do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-10jyygyg	<NULL>	The study will include patients undergoing Roux-en-Y gastric bypass and who, after 24 months of the procedure, presented weight relapse&gt; 10% of the weight lost. In addition, participants must be over 18, of both sexes and of any ethnicity.	Exclusion criteria will be considered for patients under 18; those who do not accept or are not able to perform the endoscopy exam (s) and follow-up during the study; who abandon the study during its realization; with a history of liver disease with cirrhosis or chronic active hepatitis; anticoagulated or with known clotting disorders; pregnant women who became pregnant during the study period, or intend to become pregnant during the study; patients who are participating in other similar studies; severe malnourished, anemic, chronic alcohol users or drug users; patients allergic to sedatives used during the endoscopic procedure; with a history of recent neoplasia (after reduction surgery); HIV-positive; reoperated with bariatric surgeries or for similar purposes performed before or after the study surgery; with immediate or late postoperative complications that required further surgery; patients who underwent a surgical technique other than gastric bypass with Roux-en-Y reconstruction without placing the Silastic ring.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-1028cy7j	Passion fruit intake :metabolomic approach	Data analysis completed	Intervention	2021-10-01	<NULL>	<NULL>	4936	Metabolomomic Investigation of passion fruit intake (Passiflora tenuifila)	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-15	Instituto Dante Pazzanese	Faculdade de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-1028cy7j	<NULL>	eutrophic and obese adults; both gender; no restriction to intake passion fruit.	cardiovascular disease; gastrointestinal disease; hepatic and renal disease; alcoholic; diabetes; smoker; pregnant and lactating; hormonal therapy fro menopause; use os vitamin and mineral suplements; use of antibiotics; gastrointetsinal infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-10266kdp	Comparison of the effects of High Intensity Functional Training carried out online and the same training carried out in person on risk factors for the health of physically inactive women over 50 years old	Data analysis completed	Intervention	2021-10-07	<NULL>	<NULL>	4949	Effects of High-Intensity Functional Training conducted at home via web classes and face-to-face training on cardiometabolic risk factors in sedentary women over 50 years old	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10266kdp	<NULL>	Sedentary women; non smokers; Age between 50 and 65 years old; not being a carrier of incapacitating clinical conditions or heart problems that make it impossible to practice physical exercise; agree to participate in 36 training sessions during the 12 weeks	Show changes in cardiological examinations; diagnosis of chronic obstructive pulmonary disease; angina; uncontrolled cardiac arrhythmias; severe congestive heart failure; chronic kidney disease; liver failure; severe orthopedic problems; neurological diseases; being a chronic tobacco and/or alcohol user; change in the use of medications during the study period; failure to meet the inclusion criteria;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-5t3c4tx	Evaluation of different social, clinical and functional groups of Children and Adolescents in a Multiprofessional Intensive Therapy program	Data analysis completed	Intervention	2021-10-09	<NULL>	<NULL>	4954	Assessment of sociodemographic, clinical and functional variables of children and adolescents in a Neuro Multiprofessional Intensive Therapy program	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-08	Universidade Paulista	Clinica ser especial- Centro de terapia neuromotora intensiva	https://ensaiosclinicos.gov.br/rg/RBR-5t3c4tx	<NULL>	"1 Patient with type III SMA. Informed consent form
(TCLE), term of free and informed consent (TALE) and term of use of
duly signed image."	Loss to follow-up or appearance of other comorbidities that alter the results of the applied protocol was considered as an exclusion criterion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-62w7twc	The effect of meditation on stress among university students	Data analysis completed	Intervention	2021-10-11	<NULL>	<NULL>	4963	Evaluation of a meditation program on stress symptoms among undergraduate students: a randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-08	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-62w7twc	<NULL>	Students enrolled in medical and dental courses of the Centro Universitário CESMAC, that are over 18 years old, from both genders, for phase one. In phases two and three were included students enrolled in medical and dental courses of the Centro Universitário CESMAC, that are over 18 years old, from both genders, that have presented symptoms of Stress and/or anxiety measured by the STAI and LSSI.	To be enrolled in more than 1 graduation course besides medicine or odontology; having recieved a diagnosis or being in treatment for psychotic or dissociative disorders; have been exposed to any emotionally traumatic event such as accidents, physical or sexual violence, or death threats; do not show in one of the 2 schedulled encounters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-5s6mnrf	Comparison between two techniques for correction of abdominal hernia in cancer patients	Data analysis completed	Intervention	2021-10-12	<NULL>	<NULL>	4977	Comparison between robot-assisted video laparoscopic Rives-Stoppa techniques in ventral incisional hernia repair in cancer patients: a prospective and randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5s6mnrf	<NULL>	Adult patients (18-65 years) with any abdominal or pelvic incisional hernia following oncologic surgery	Patients that were pregnant, were under systemic chemotherapy, or presented any contraindication to general anesthesia or laparoscopy intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-8kmydzj	Impact of topical testosterone on lipid profile in women with decreased sexual desire: A randomized controlled double-blind study.	Data analysis completed	Intervention	2021-11-03	<NULL>	<NULL>	5016	The impact of transdermal Testosterone Nanoemulsion on lipid profile in women with Hypoactive Sexual Desire: A double-blind randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-05	universidade federal de sao paulo	universidade federal de sao paulo	https://ensaiosclinicos.gov.br/rg/RBR-8kmydzj	<NULL>	Inclusion criteria:Women over 18 years old; maximum age 45 years; Decreased sexual desire; Present sexual activity, with at least one sexual event per month, with current partner; Be in good general health; Women over 40 should have a clinically acceptable mammogram within the last 2 years; Be on contraceptive method.	Exclusion Criteria:Sexual dysfunction caused by another medical condition;Body mass index (BMI) below 18 kg / m2 or above 35 kg / m2; undiagnosed genital bleeding;Use of androgen therapy in the last 6 months (testosterone implant, testosterone transdermal cream, tibolone, oral testosterone or injectable testosterone); Antiandrogenic therapy for acne or hirsutism in the last 5 years; Hyperandrogenism Syndrome, such as Polycystic Ovary Syndrome; Moderate or severe acne, hirsutism, and androgenetic alopecia; Any serious clinical or psychiatric illness, active cancer, or treatment of malignancy within the last six months; Decompensated clinical disease; Any clinically significant skin abnormalities in the study medication application area; Consumption of more than three standard alcoholic drinks per day; pregnancy or lactation; Do not attend our center for follow-up study visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-2pbbrvg	Evaluation of histological measurement of different graft associations in maxillary sinus after surgery for sinus cavity elevation in antral cavities	Data analysis completed	Intervention	2021-11-08	<NULL>	<NULL>	5025	Histomorphometric evaluation of different graft associations for maxillary sinus elevation in antral cavities	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-13	Faculdade São Leopoldo Mandic	Associação Brasileira de Odontologia - MT	https://ensaiosclinicos.gov.br/rg/RBR-2pbbrvg	<NULL>	The study included patients older than 18 years, without pathologies of the maxillary sinus, with maxillary sinuses classified as wide (Chan et al. 2014), and with a posterior bone height below 3 mm in the 2nd premolar and 1st molar region.	The exclusion criteria applied were patients with a chronic disease that would contraindicate the surgical procedure, such as uncontrolled diabetes, hypertension and head/neck radiation, smokers (more than 5 cigarettes per day), and patients with habits that could interfere with the treatment, such as alcoholism and drug use, use of prolonged bisphosphonate therapy, and/or a history of previous surgical procedure for maxillary sinus graft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-4d9dmqz	Influence of polymorphisms on the sod3, pparα genes on physical performance and redox balacing of runners supplemented with a single dose of grape juice	Data analysis completed	Intervention	2021-11-12	<NULL>	<NULL>	5036	Influence of polymorphisms on the sod3, pparα and actn3 genes on oxidative stress, dna methilation and performance in corridors supplemented with red grape juice	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Ufpb - Universidade Federal da Paraiba	Ufpb - Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-4d9dmqz	<NULL>	Inclusion criteria were defined as: athletes should have been training for at least one year with a frequency of at least four weekly sessions and for at least two months without interruption and taking part in competitions regularly. They also should not have any chronic condition or degenerative diseases, did not smoke, and were not using any long-term medication.	Participants should not consume purple grapes or their derivatives often; and/or dietary supplements, vitamins or bioactive substances present in the grape (polyphenols). Athletes who suffered from skeletal muscle injuries, altered dietary habits or had inconsistent training patterns, started using medication or did not perform some of the study experimental procedures were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-98tx28b	Effect of different foods on blood glucose in Type 2 Diabetes patients	Data analysis completed	Intervention	2021-11-12	<NULL>	<NULL>	5047	Acute glycemic response after adding different foods to breakfast of Type 2 Diabetics	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade de Brasília - Faculdade de Ceilândia	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-98tx28b	<NULL>	Eligibility criteria included the following: male, type 2 diabetic (American Diabetes Association, 2019), age 30–60 years, regular breakfast consumer (≥100 kcal ingested within 2 h of waking on ≥4 d/ week), willingness to eat all test foods, no self-reported allergy to the foods provided in the study, and no self-reported sleep disorders.	Were excluded the participants in use of exogenous insulin, with diabetes health complications, with reported gastrointestinal disorders or irregular intestinal rhythm, and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-2fr526n	Effects of cell therapy with mesenchymal stem cells and platelet-rich plasma in the treatment of knee osteoarthritis	Data analysis completed	Intervention	2021-11-16	<NULL>	<NULL>	5050	Effects of cell therapy with mesenchymal stem cells from adipose tissue and platelet-rich plasma in the treatment of osteoartrite that was not responsive to drug treatment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-29	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2fr526n	<NULL>	Volunteer individuals were included; diagnosed through physical assessment; be classified by imaging with osteoarthritis grade II to IV; who already had an indication for knee surgery; patients unresponsive to conservative treatment (physical and drug) commonly used in the Unified Health System (SUS) for at least 6 months.	Individuals with extreme deformities of the knee joint were excluded; who reported having hemophilia, anemia, gastrointestinal diseases, cancer, thyroid, liver, and previous nephrological disorders and HIV; patients who were chronically using immunosuppressive and anticoagulant drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-9tk9pwz	Study comparing the efficacy of fosfomycin and ciprofloxacin antibiotics in the antibiotic prophylaxis of transrectal prostate biopsy	Data analysis completed	Intervention	2021-11-23	<NULL>	<NULL>	5058	Comparative study between fosfomycin and ciprofloxacin in transrectal prostate biopsy prophylaxis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-08	Universidade Federal do Paraná - Campus Toledo	Universidade Federal do Paraná - Campus Toledo	https://ensaiosclinicos.gov.br/rg/RBR-9tk9pwz	<NULL>	male gender; have a formal indication for prostate biopsy; aged between 18 and 100 years.	patients who for some reason cannot take the proposed medications; patients with a history of severe bleeding complications during the biopsy procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-34tv3fz	Assessment of Locked Nose Improvement in patients who received a Nasal Implant	Data analysis completed	Observational	2021-12-06	<NULL>	<NULL>	5076	"Evaluation of the improvement rate of Nasal Obstruction by the NOSE Scale in patients
submitted to Poly(ε-caprolactone) Absorbable Nasal Implant (PCL)"	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-34tv3fz	<NULL>	Patients aged between 50 and 79 years; with insufficiency of the nasal lateral wall confirmed through the positive Modified Cottle maneuver; with severe or extreme nasal obstruction in the evaluation by the NOSE Scale (Nasal Obstruction Symptom Evaluation Scale) (score ≥ 55); impossibility or refusal to perform functional rhinoplasty; and lack of significant improvement after clinical treatment for at least four continuous months.	Smoking patients; with decompensated chronic rhinitis; with nasosinusal polyposis; with nasal granulomatous diseases; with any inflammatory or infectious diseases or conditions in the nasal or facial region; with a history of nasal implants or some type of nasal filling; with immunosuppressive disease; with healing disorders; with uncontrolled systemic diseases such as diabetes or heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-9wkvm5b	Benefits of non-invasive pulmonary ventilation soon after tube removal in the postoperative period of heart surgery	Data analysis completed	Intervention	2021-12-07	<NULL>	<NULL>	5083	Benefits of Non-Invasive Ventilation immediately after extubation in the Postoperative period of Cardiac Surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Faculdade Nobre de Feira de Santana	Faculdade Nobre de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-9wkvm5b	<NULL>	This study included patients of both sexes; aged 18 years or older; who underwent to coronary artery bypass grafting with median sternotomy and cardiopulmonary bypass.	Patients with hemodynamic instability before noninvasive ventilation; who were not cooperative or who had contraindications for the use of noninvasive ventilation; chronic pulmonary disease; absence of blood gas analysis in some of the study phases; physical limitations that compromised the performance of functional tests were excluded; difficulty understanding to perform the applied tests; surgical reintervention; more than 24 hours in invasive mechanical ventilation; patients who refused to sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-9x5whvf	Effect of tomato supplementation on oxidative stress and cardiac function in hemodialysis patients	Data analysis completed	Intervention	2021-12-08	<NULL>	<NULL>	5085	Effect of tomato (Lycopersicon esculentum) supplementation on oxidative stress markers and cardiovascular function in patients with chronic kidney disease treated by hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Faculdade de Medicina de Botucatu UNESP	Faculdade de Medicina de Botucatu UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9x5whvf	<NULL>	Patients older than 18 years old and prevalent in chronic HD for at least three months were included;	Patients with cancer, HIV-positive undergoing antiretroviral therapy, end-stage liver disease, heart failure disease with ejection fraction less than 30%, clinical diagnosis of acute infection, (or using antibiotics), chronic inflammatory diseases, such as systemic lupus erythematosus and chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-87g6ny8	Effect of resveratrol combined on Exercise program on health-related outcomes of breast cancer survivors: randomized, double-blind clinical trial	Data analysis completed	Intervention	2021-12-08	<NULL>	<NULL>	5087	Effect of resveratrol combined on Exercise program on health-related outcomes of breast cancer survivors: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Pernambuco	Fundação de apoio à Ciência e Tecnologia de Pernambuco - FACEPE	https://ensaiosclinicos.gov.br/rg/RBR-87g6ny8	<NULL>	"Postmenopause; 
high BMI; 
sedentary lifestyle (mild physical activity, less than 150 minutes per week, American College of Sports Medicine 2014)"	"Recurrence of breast cancer;
 bone metastasis; 
bone fractures; 
severe anemia; 
platelet count less than 50x109ml; 
participation in other physical exercise programs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-8q96hsh	Comparison between two types of ergonomic adjustments in cycling	Data analysis completed	Intervention	2021-12-09	<NULL>	<NULL>	5093	Comparison Between 3D Kinematic Bikefitting and Traditional Bicycle Adjustment Recommendations: A Double-Blind Randomized Controlled Trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-09-07	Universidade Cidade de Sao Paulo	Universidade Cidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8q96hsh	<NULL>	amateur ciclists	continuous use of painkillers; ride with proposed bike setup	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-87pc5z9	Effects of auriculotherapy on musculoskeletal pain in elementary school teachers	Data analysis completed	Intervention	2021-12-10	<NULL>	<NULL>	5095	Effects of auriculotherapy on musculoskeletal disorders in elementary school teachers	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Tiago Veloso Neves	Fundação Escola de Saúde Pública de Palmas	https://ensaiosclinicos.gov.br/rg/RBR-87pc5z9	<NULL>	The study included teachers of all ages and genders, who had musculoskeletal disorders and who agreed to participate in the study by signing the Informed Consent Form (FICF).	Teachers who did not have musculoskeletal disorders, who were on sick leave, maternity leave, vacation, medical certificate, and/or refused to participate in the research, and people who had an allergy to adhesive tape were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-6wy5y4t	Effects of Trunk-Specific Exercise on Pain, Inflammation, and Hormonal Release in Women with Back Pain	Data analysis completed	Intervention	2021-12-13	<NULL>	<NULL>	5099	Acute neuroimunoendocrin effects of high and low volume core training in women with unspecific chronic low back pain: a crossover study	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6wy5y4t	<NULL>	Women will be included in the research with a clinical diagnosis of nonspecific chronic low back pain, between 18 and 40 years old, who have complained of low back pain for more than 3 months, with a pain level between 3 and 6 on the Numeric Pain Rating Scale (NRS) (COSTA, et al. 2008). The volunteers will need to present a body mass index (BMI &lt;30 kg/cm2); not being pregnant; not having given birth for less than three months; not having undergone any surgery on the spine; not having performed any type of exercise in the last three months; not being undergoing any type of pain treatment; and without the use of analgesic, anti-inflammatory, opioid or immunosuppressive medication.	Participants who miss one of the days of the tests or who have any psychiatric or cognitive impairment, hearing, visual or communication disorders that make it impossible to carry out the protocol will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-10cr49dr	Analysis of foraminal patency attainment rates by undergraduate students - An &quot;in vivo&quot; Study	Data analysis completed	Intervention	2021-12-13	<NULL>	<NULL>	5100	Analysis of foraminal patency attainment rates by undergraduate students - An &quot;in vivo&quot; Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-10cr49dr	<NULL>	Patients with one or more dental elements indicated for radical endodontic treatment; complete rhizogenesis	Dental elements with previously performed endodontic treatments; root curvatures; root resorption processes; anatomical complexities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-24z8q24	The influence of Pilates on the strength and functionality of the elderly	Data analysis completed	Intervention	2021-12-14	<NULL>	<NULL>	5109	Biological, behavioral and sociocultural analysis in adults and elderly individuals who practice physical exercises	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-24z8q24	<NULL>	Being between 60 and 79 years of age; not having been practicing physical exercises for at least six months; presenting a medical certificate claiming to be fit for Pilates, presenting a score less or equal 14 points in the Clinical-Functional Vulnerability Index-20 classified as elderly with moderate risk of clinical-functional vulnerability	Neurological; cardiovascular; respiratory and orthopedic diseases that prevent Pilates exercises; smoking habits; wheelchair use; frequency of less than 75% in classes during the time proposed for the established training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-9jwcykc	Effects of Pilates with and without elastic resistance on health variables in postmenopausal women with low back pain	Data analysis completed	Intervention	2021-12-23	<NULL>	<NULL>	5128	Effects of the Pilates method on balance, gait, falls and IGF-1 related to activities of daily living in elderly women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9jwcykc	<NULL>	"postmenopausal woman; present non specific chronic low back pain; low back pain for more than three months;  
no history of engagement in physical exercise during the previous three months"	be on hormone replacement therapy or analgesics; practice other types of exercises or treatments during the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-8dzrvjg	Biperiden effect to reduce the desire to use cocaine/crack	Data analysis completed	Intervention	2022-01-06	<NULL>	<NULL>	5135	Effects of biperiden (muscarinic antagonist) on cocaine/crack dependence	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-06-09	Universidade Federal de São Paulo	Secretaria Nacional de Cuidados e Prevenção às Drogas - SENAPRED	https://ensaiosclinicos.gov.br/rg/RBR-8dzrvjg	<NULL>	male; age between 18 and 70 years; severe disorder related to the use of cocaine or crack according to the Diagnostic and Statistical Manual of Mental Disorders criteria, 5th edition (DSM-5 criteria) (published by  American Psychiatric Association, 2013)	other severe psychiatric disorders severe, such as schizophrenia and bipolar mood disorder; severe dependence criteria for other drugs (except tobacco); severe cognitive impairment; Illiteracy; compulsory hospitalization; hearing deficiency; transference to other health service with no partnership with the project; hospitalization discharge due to agressive issues or at the request of the participant; previous use of biperiden	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-8t9bqkg	Children with Developmental Coordination Disorder: relationships and predictors of motor deficits and the current and longitudinal interventional impact	Data analysis completed	Intervention	2022-01-10	<NULL>	<NULL>	5140	Children with Developmental Coordinating Disorder: relationships and predictors of motor deficits and the current and longitudinal interventional impact	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8t9bqkg	<NULL>	Children from low-income families (criterion defined from the economic classification questionnaire of the Brazilian Association of Research Companies); age between 6 and 7 years; overweight or obese (defined by Body Mass Index); proper weight (defined by Body Mass Index); with motor delay.	Children under 6 and over 7 years old; children from middle and upper socioeconomic classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7jx2byj	Treatment of Endometriosis using the drug methotrexate associated with lipid substances that facilitate the action of medication at the site of the disease	Data analysis completed	Intervention	2022-01-11	<NULL>	<NULL>	5141	Treatment of Deeply infiltrative endometriosis with intravenous methotrexate carried in lipid core nanoparticles (LDE-ddMtx): a prospective pilot study	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2019-06-20	Faculdade de Medicina da Universidade de São Paulo - USP	Centro de Estudo e Pesquisa do Hospital Perola Byington	https://ensaiosclinicos.gov.br/rg/RBR-7jx2byj	<NULL>	We included women in the reproductive period between 30 and 50 years, with no future intention of pregnancy; DIE affecting at least the inner muscular intestinal layer; with at least one pelvic pain symptom (dysmenorrhea, deep dyspareunia, chronic pelvic pain, dyschezia and/or dysuria during the menstrual period) with a score of 7 or higher on the visual analogue scale (VAS) (Maxwell et al., 1978), with no current use of hormone therapy including gonadotropin-releasing hormone (GnRH) analogs or progestogens for at least six months prior to the beginning of the study or no use of combined hormonal contraceptives for three months prior to medication of the present study or still use of any hormonal therapy and maintain complaints of significative pain (VAS equal or higher than 7); and no pregnancy.	Breastfeeding, any immunodeficiency, alcoholism, peptic ulcer, hepatic, renal or hematological disorders, active lung disease and known sensitivity to methotrexate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-6wpdvjk	Effects of radiofrequency and microneedling on the quality of life in women with white marks	Data analysis completed	Intervention	2022-01-13	<NULL>	<NULL>	5145	Effects of radiofrequency and microneedling on the quality of life in women with alba stretches	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6wpdvjk	<NULL>	Volunteers in good health; who did not have severe circulatory or healing problems; who had not undergone any treatment for the dysfunction in the past 6 months	Volunteers who were being treated with photosensitive drugs, anti-inflammatory drugs, antibiotics, immunosuppressive drugs; with suspicion or pregnancy plans; who have used retinoids in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-3f8dm6q	Olfactory training with essential oils in patients with olfaction sequelae after COVID-19	Data analysis completed	Intervention	2022-01-23	<NULL>	<NULL>	5160	Advanced olfactory training in post-COVID patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3f8dm6q	<NULL>	Patients who complain of anosmia or hyposmia after SARS-CoV-2 infection less than 3 months after symptom onset; convalescing from her COVID-19 disease, with onset of disease symptoms for at least 4 weeks; Patients who underwent RT-PCR test at symptom onset, with detection of SARS-CoV-2; Patients who can give valid written informed consent; Patients motivated to participate in the study; Adult patients aged 18-60 years.	Patients who cannot give valid written informed consent; Patients with a previous history of more than one SARS-CoV-2 infection Patients with nasosinusal diseases such as chronic rhinosinusitis or nasal masses; History of previous traumatic brain injury with olfactory sequelae; History of olfaction disorder prior to SARS CoV-2 infection; Patients with any diagnosed neurological disease known to affect olfactory function; Patients unable to read Portuguese; Patients who are already using an oral glucocorticoid; Patients who have already started some form of therapy for the olfactory disorder caused by COVID-19; Known hypersensitivity to any item used in any of the proposed olfactory training;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7wfrs6k	Determination of Anatomic Diameters in Different Dental Groups - An &quot;In Vivo&quot; Study	Data analysis completed	Intervention	2022-01-25	<NULL>	<NULL>	5165	Determination of Anatomic Diameters in Different Dental Groups - An &quot;In Vivo&quot; Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-7wfrs6k	<NULL>	Patients with one or more dental elements indicated for radical endodontic treatment; that have complete root formation	Dental elements with previously performed endodontic treatments; root curvatures; root resorption processes; anatomical complexity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-66n5c5r	Effects of Cognitive Behavioral Couple Therapy combined with Mindfulness on mindful attention, depressive symptoms and dyadic adjustment: A randomized clinical trial	Data analysis completed	Intervention	2022-01-25	<NULL>	<NULL>	5166	Cognitive Behavioral Couple Therapy Combined with Mindfulness	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Universidade Metodista de São Paulo	Universidade Metodista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66n5c5r	<NULL>	age between 18 and 60 years; being in a heterosexual relationship; Portuguese as their mother tongue; literate and having education level up to complete higher education; having one or more year of marriage or cohabitation; to present conflict in the relationship related to communication difficulties (we used the Romantic Partner Conflict Scale adapted); naive practitioner in the Mindfulness meditation exercise; monthly income per family up to R$6,000,00; having consent of both spouses to participate in the study.	Having any severe clinical psychological disorder; being drug addict or taking psychiatric medication (we used the interview, the Alcohol, Smoking, and Substance Involvement Screening Test - ASSIST, and the General Health Questionnaire - GHQ-12).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-5x9ry6s	Association of botox with microsurgery of the nasal septum depressor muscle in the treatment of gingival smile.	Data analysis completed	Intervention	2022-01-26	<NULL>	<NULL>	5172	The influence of microsurgery of the nasal septum depressor muscle associated with botulinum toxin in the treatment of gingival smile.	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-01-30	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5x9ry6s	<NULL>	Gummy smile above 2mm	Gingival exposure excess (skeletal); use of antibiotics and muscle relaxant: pregnancy and pregnancy; under 18	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7gcggcm	Influence of compensating curves on the masticatory performance and swallowing threshold of complete denture wearers: Randomized clinical trial	Data analysis completed	Intervention	2022-01-28	<NULL>	<NULL>	5188	Influence of compensating curve on the masticatory function of complete denture wearers (Randomized clinical trial)	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7gcggcm	<NULL>	Totally edentulous in the upper and lower arches; age between 40 and 70 years; good general health; having alveolar ridges classified as horizontal or distal ascending in the mesio-distal direction; and normal in the buccolingual direction, with mandibular-symphysis bone height grater than 16 mm	Presence of clinically detected parafunctional habits; history of symptoms in the temporomandibular joints and masticatory muscles; have osteoporosis; having Type I and II Diabetes Mellitus; to be a smoker; apparent xerostomia; patients with uncontrolled systemic diseases; individuals who underwent radiotherapy in the head and neck	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-8k2vpx	Comparison of two types of procedures used to prevent venous thrombosis after total knee prosthesis surgery: with medication or mechanical device	Data analysis completed	Intervention	2019-06-04	<NULL>	<NULL>	5193	Comparison of the effect of the type of Thromboprophylaxis (Mechanical or Pharmacological) on blood loss and postoperative edema in total knee arthroplasty	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-05	Hospital Maradei	Faculdade de Medicina da Universidade de São Paulo (FMUSP)	https://ensaiosclinicos.gov.br/rg/RBR-8k2vpx	<NULL>	Adult patients submitted to total knee arthroplasty	Personal history of venous thromboembolism (deep vein thrombosis or pulmonary embolism); coagulation disorders; peptic ulcer disease; liver disease; enoxaparin allergy; malignant tumors;  patients undergoing any surgery in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-9x99fg8	Assessment of the degree of muscle injury and impairment of strength and movement in Knee Replacement Surgery using a pneumatic tourniquet in an optimized way	Data analysis completed	Intervention	2022-02-11	<NULL>	<NULL>	5207	Assessment of the degree of muscle injury and impairment of quadriceps motor function with the use of an optimized tourniquet in Total  Knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Instituto Nacional de Traumatologia e Ortopedia INTO	Instituto Nacional de Traumatologia e Ortopedia INTO	https://ensaiosclinicos.gov.br/rg/RBR-9x99fg8	<NULL>	The study will include patients with knee osteoarthritis glued to the cemented TKA and who agreed to participate in the research by signing the Informed Consent Form (ICF).	Patients with uncontrolled sitemic arterial hypertension and chronic heart disease, smokers, patients with a history of previous surgery on the same joint, patients with evidence of joint infection, patients with congenital or acquired coagulopathies, patients on chronic use of oral and anticoagulants will be excluded from the study.  corticosteroids, patients with malignant neoplasms and autoimmune diseases, patients with indication for revision surgery and patients with severe axis deviation of the lower limbs (varus&gt; 10 ° and varus&gt; 15 °).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-6d4qyr3	Evaluation of educational actions for nurses in intensive care units about the passing of patients&apos; cases	Data analysis completed	Intervention	2022-02-15	<NULL>	<NULL>	5217	"Effectiveness of educational actions for intensive care nurses on transfer
of care"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Faculdade de Enfermagem - Universidade do Estado do Rio de Janeiro	Faculdade de Enfermagem - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6d4qyr3	<NULL>	nurses; nursing residents of the first year; nursing residents of the second year	professionals who are on sick leave, vacation or other types of leave during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-10kpkctx	Evaluation of the influence of saline solution temperature on the level of pain and comfort in patients with long-term Wounds	Data analysis completed	Intervention	2022-02-16	<NULL>	<NULL>	5221	Evaluation of the influence of the saline solution temperature on the level of pain and comfort in patients with Chronic Wounds	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-09-17	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10kpkctx	<NULL>	Patients over 18 years of age; both genders; with chronic wounds lasting at least 8 weeks	Individuals under the influence of psychoactive drugs; patients diagnosed with neuropathic wounds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-8556fzp	Comparison of the accuracy of guided and conventional surgery for implant placement	Data analysis completed	Intervention	2022-02-17	<NULL>	<NULL>	5222	Guided and conventional surgery for implant placement: clinical, radiographic, microbiological, imunoenzimatic and patient-centered evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-06	Universidade Paulista	Universidade Santa Úrsula	https://ensaiosclinicos.gov.br/rg/RBR-8556fzp	<NULL>	Total edentulous maxillary patients; minimum bone thickness of 5.5 mm for implant placement; minimum bone height of 9 mm for placement of 6 implants.	Pregnancy; lactation; antibiotic therapy in the last 6 months, long-term use of medications that could alter osseointegration, such as anti-inflammatory drugs, bisphosphates or immunosuppressive drugs; graft needs before or during surgery; history of previous regenerative procedures in the area designated for implant installation;Patients with severe complications associated with type 2 diabetes, cardiovascular disease; peripheral vascular diseases  such as ulcers, gangrene or amputation; neuropathies; nephropathies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-8mj8c63	Jumps and muscle microdamages	Data analysis completed	Observational	2022-02-21	<NULL>	<NULL>	5231	Eccentric utilization rate and muscle microinjuries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-8mj8c63	<NULL>	Be between 18 and 40 years of age; not be obese; practice more than 150 minutes of daily physical activity; Answer yes to all PAR-Q questions; do not use drugs or nutritional supplements.	Have presented osteomyoarticular lesion in the last and months; be using nutritional supplements; be an athlete in any sport; having a lower limb prosthesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-5c2qxsr	The effect of the physiotherapy technique: Hyperinflation maneuver with the Peep valve on lung compliance in children operated on for congenital heart disease	Data analysis completed	Intervention	2022-03-02	<NULL>	<NULL>	5249	Effect of Manual Hyperinsuflation Maneuver Associated with Peep valve on pulmonary compliance in post-operative of congenital cardiopathy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Jéssica Câmara Guimarães	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5c2qxsr	<NULL>	Pediatric patients of both genders will be eligible for the study; from 0 to 14 years of age; admitted to the Pediatric Intensive Care Center of the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto, University of São Paulo; in the postoperative period of cardiac surgery for correction of congenital heart disease; submitted to mechanical ventilation; with chest X-ray without signs of pneumothorax.	Exclusion criteria in the study will be patients diagnosed with metabolic and or genetic disease that course with muscle weakness and chest abnormalities; preoperative mechanical ventilation; postoperative hemodynamic instability; request of parents or guardians for the child not to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-7hc7ty5	The occurrence of auditory and vestibular symptoms in people with fibromyalgia	Data analysis completed	Observational	2022-02-18	<NULL>	<NULL>	5253	The incidence of hearing and vestibular changes in people with fibromyalgia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	Débora Pereira Fernandes	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7hc7ty5	<NULL>	People with a medical diagnosis of Fibromyalgia. Over 18 years of age. Residents of the Federative Republic of Brazil	People who denied having a medical diagnosis of fibromyalgia. People who denied having any type of auditory or vestibular symptoms. People without internet access and interest to answer the question form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-7vd7yry	Influence of manual therapy techniques on cardiovascular modulation and cerebral circulation in healthy subjects	Data analysis completed	Intervention	2022-03-03	<NULL>	<NULL>	5254	Influence of manual therapy techniques on autonomic cardiovascular modulation and cerebral blood flow compared to placebo in young healthy subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7vd7yry	<NULL>	"voluntary participation;
understanding of the questions in the assessment;
Age greater than 18 years."	"Pain; Diseases that affect the SNA;
Changes in the ECG; Medications that affect the cardiovascular system;
Use of stimulant drinks 24 hours before."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-977fm24	The effect of laser application and desensitizing gel in the treatment of dentinal hypersensitivity	Data analysis completed	Intervention	2022-03-03	<NULL>	<NULL>	5255	Protocols for the treatment of Dentinal Hypersensitivity with Low-level Laser and Potassium Nitrate in a risk group: a longitudinal clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia  da Universidade de São Paulo	Faculdade de Odontologia  da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-977fm24	<NULL>	Both genders, aged between 18 and 45 years old; have good general health; agree to participate in accordance with the Informed Consent Form (TCLE); present at least one tooth with Hypersensitivity reported in the cervical region, which will have to have a graded sensitivity equal to or greater than 4 on the VAS scale	Present active carious lesions or with defective restorations in the tooth to be analyzed; have enough dentin loss that requires restorative treatment; having undergone any professional desensitizing treatment in the past 6 months; use of desensitizing pastes within 3 months; use of anti-inflammatory drugs or analgesics at the time of recruitment; volunteers who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-2tz9dky	Safety and tolerability study to evaluate of Pentosan Polysulfate Sodium in treating subjects with Mucopolysaccharidosis type VI	Data analysis completed	Intervention	2021-11-22	<NULL>	<NULL>	5267	A phase 2, randomized, double blind, placebo-controlled study to evaluate the safety and tolerability of Pentosan Polysulfate Sodium in treating subjects with Mucopolysaccharidosis (MPS) type VI (Maroteaux-Lamy Syndrome)	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2021-06-22	Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2tz9dky	<NULL>	Male and female subjects greater than or equal to 5 years of age; confirmed diagnosis by genetic testing and/or enzyme activity of  Mucopolysaccharidosis (MPS) Type VI (N-acetylgalactosamine-4-sulfatase deficiency and a second normal sulfatase enzyme); must be on enzyme replacement therapy (ERT) for greater than or equal to 1 year; must be on at stable dose of enzyme replacement therapy (ERT) for 3 months prior to baseline; must have a mean pain score of a minimum of 3 and a maximum of 9 on the Faces Pain Scale-Revised (FPS-R) taken from the first 5 consecutive measurements at screening; able to walk 30 metres with or without use of an assistive device; 6MWT less than or equal to 70% (percent) predicted of normative mean value for age; participant demonstrates an impairment of ROM in at least one shoulder; participant or parent, or legally acceptable representative sufficiently able to understand the purposes and risks of the study and able to provide written informed consent or in the case of participants age less then 18 years, provide written assent (if required) and written informed consent by a legally authorized representative after the nature of the study has been explained, and prior to any research-related procedures or study assessment; if applicable, participants must be willing to comply with the medically acceptable contraceptive requirements of the study from screening to at least 28 days after the last investigational product (IP) administration; participants should not be pregnant or breastfeeding at the time of study entry; participants must be willing and able to comply with all scheduled visits, treatment plan, laboratory tests, and other study procedures	Documented or reported history of increased bleeding tendency in the presence or absence of anticoagulant or antiplatelet drugs; history of heparin induced thrombocytopenia; current treatment with anticoagulants or antiplatelet drugs, excluding aspirin less than or equal to 100 mg per day; absence of limitation in upper extremity fine motor skills; absence of shoulder joint Range of Motion (ROM) limitations; participant taking opioids within 2 weeks of Day 1 or unwilling to stop the treatment opioids throughout the study; parenteral iloprost from 12 weeks before Day 1 and throughout the study; parenteral bisphosphonates from 12 months before Day 1 and throughout the study; currently active or recent history (within preceding 12 months) of a gastric or duodenal ulcer, or suspicion of gastrointestinal (GI) tract bleeding; coagulation parameters or platelets outside laboratory reference range, liver function tests greater than or equal to 1.5 × upper limit of normal (ULN), or estimated glomerular filtration rate (eGFR) less then 30 mL per min at Screening; hepatic synthetic insufficiency (including Gilbert’s Syndrome); history of bone marrow transplant or haematopoietic stem cell transplant; history or evidence of chondrocalcinosis or fibromyalgia; history or evidence of HIV, hepatitis B or hepatitis C; major surgery within 12 weeks preceding Day 1 or anticipated surgery in the study period; medical history or evidence of any clinically significant active or chronic condition involving the musculoskeletal system, which in the opinion of the Investigator may impact assessment of safety or efficacy parameters or the validity of study results; current or recent immunosuppressive or immunomodulatory systemic therapy; currently hospitalised; any acute illness within 2 weeks of baseline; a history of drug or alcohol abuse and/or dependence as documented by participant/caregiver reporting within the 12 months preceding screening; participation in another clinical trial or administration of any investigational product or experimental product within 12 weeks or five half-lives (whichever is longer) preceding Day 1; history of significant hypersensitivity to pentosan polysulfate sodium (PPS) or drugs of a similar chemical or pharmacological class; any clinically significant abnormalities as judged by the Investigator at screening; history of or current clinically significant gastrointestinal (GI), hepatic, renal, cardiovascular, respiratory, endocrine, oncological, immunological, neurological, ophthalmological (including existing pigmentary maculopathy), haematological or psychiatric disorder or any other condition (with the exception of signs and symptoms relating to MPS VI), which in the opinion of the Investigator or Sponsor would jeopardize the safety of the subject or the validity of the study results; an employee of the Sponsor or research site personnel directly affiliated with this study or their immediate family members defined as a spouse, parent, sibling, or child, whether biological or legally adopted	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:01
RBR-5ydbctk	Study of a Device for Bone Augmentation in maxilla	Data analysis completed	Intervention	2022-03-24	<NULL>	<NULL>	5298	Evaluation of a New Device for Horizontal Bidirecional Bone Augmentation in maxila: a clinical and tomographic analysis	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2019-10-10	Luís Guilherme Scavone de Macedo	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5ydbctk	<NULL>	Ages between 18 and 65 years, who have bidirectional horizontal maxilla atrophy and who intend to have oral rehabilitation with the use of osseointegrated implants.	Pregnant, diabetics, immunocompromised patients, smokers, who are using medications that may interfere with the study results. Patients who present fracture of the bone walls during the procedure make it impossible to fix the device.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-4m5pdbf	Anesthesia without Narcotic Analgesic for Obesity Surgery: is there a benefit?	Data analysis completed	Intervention	2022-03-25	<NULL>	<NULL>	5300	Opioid-free Anesthesia for Laparoscopic Gastroplasty: is there a benefit?	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-01-13	Universidade Federal do Paraná	Hospital Nossa Senhora das Graças	https://ensaiosclinicos.gov.br/rg/RBR-4m5pdbf	<NULL>	Body mass index major or equal to 35; indication for gastroplasty surgery; age over 18 yers old	Refusal to participate in the study; chronic pain or chronic use of analgesics; any condition or pathology that could change the perception of pain; heart blockages or major arrhythmias; patients anesthetized differently from the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-10qfrrgh	Can the size of the wear near the gingiva affect pain intensity and imaging findings?	Data analysis completed	Observational	2022-03-27	<NULL>	<NULL>	5305	Analysis of dental pain and pulp status in teeth with non-carious cervical lesions and dental hypersensitivity- clinical, radiographic and tomographic diagnosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-13	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10qfrrgh	<NULL>	Participants included in this study, should be at least 18 years old, in good general and oral health and were required to have NCCL (Non-carious cervical lesions).	Teeth with presence of dental caries and restorations or fractures were excluded. Participants who underwent recent periodontal surgery or desensitizing treatment in the last three months and those with dental prostheses and orthodontics apparatus, teeth with or under endodontic treatment. In addition, pregnant and lactating women, individuals with bruxism or any systemic/psychological diseases, anti-inflammatory or analgesic drug users, smokers or patients undergoing tooth-whitening procedures were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-5q6x56k	Monitoring heart disease patients via WhatsApp during the COVID-19 pandemic	Data analysis completed	Intervention	2022-03-28	<NULL>	<NULL>	5310	Follow up of outpatients with heart failure with reduced ejection fraction via WhatsApp during the COVID-19 pandemic	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2020-06-01	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-5q6x56k	<NULL>	Patients were eligible for inclusion if they were 18 years of age or older, had heart failure with an ejection fraction less than or equal to 40%, regardless of etiology, assessed by an echocardiogram performed within a maximum of six months before randomization, functional class I- III (New York Heart Association), optimized drug therapy, cell phone with access to the Whatsapp® application.	Patients with any non-cardiac condition that, in the investigator&apos;s opinion, leads to a life expectancy of less than 12 months, functional class IV (NYHA), cardiogenic shock, cardiac surgery within the previous 8 weeks, heart transplant waiting list, failure chronic kidney disease, uncontrolled high blood pressure, inability to understand or interact with text messages due to illiteracy, cognitive impairment or social problems, severe depression and uncontrolled arrhythmia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-89mvgbm	Effects of dual task training and tDCS in children with spastic cerebral palsy	Data analysis completed	Intervention	2022-04-01	<NULL>	<NULL>	5324	Motor-cognitive dual task associated with anodic Transcranial Direct Current Stimulation in children with Spastic Cerebral Palsy: controlled, randomized and double bling clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-89mvgbm	<NULL>	Diagnosis of spastic cerebral palsy; functional classification on Levels I, II or III of the Gross Motor Function Classification System (GMFCS); ability to walk independently in at least the previous 12 months, even if requiring a gait-assistance device; age between six and 12 years (age corresponding to the period of concrete operations and logical thinking); degree of understanding and cooperation compatible with the execution of the proposed activities; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant.	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-46vhrkj	Neuromodulation in patients undergoing hemodialysis	Data analysis completed	Intervention	2022-04-04	<NULL>	<NULL>	5326	Transcranial Direct Current Stimulation for pain and functionality in patients undergoing Hemodialysis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-46vhrkj	<NULL>	Age between 18 and 75 years; previous medical evaluation with clinical diagnosis of depression, anxiety, chronic pain and pressure lability and being on hemodialysis treatment	Evidence of any cognitive deficit (senile dementia, Alzheimer&apos;s); presence of physical and / or organic difficulties; individuals with severe cardiovascular risk or hemodynamically unstable; history of seizures or epileptic disease; pregnancy; metallic implants in the head or neck and cardiac pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-8cz9kfq	Capsiate supplementation plus resistance training in adults	Data analysis completed	Intervention	2022-04-06	<NULL>	<NULL>	5331	Changes on performance, body composition and biochemical parameters in young adults after acute and chronic pre-workout supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8cz9kfq	<NULL>	Men aged between 18 and 35 years; healthy; untrained for resistance training and without chronic diseases; do not make use of food supplements and steroids	Participants who miss more than three training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-7qwsyny	Understanding of individuals with Parkinson´s Disease about social isolation and ways of prevention, monitor, and Treatment Remotely to face the COVID-19 pandemic.	Data analysis completed	Intervention	2022-04-11	<NULL>	<NULL>	5337	Perception of individuals with Parkinson´s Disease about social isolation and strategies of prevention, monitoring, and treatment through Telehealth to face the COVID-19 pandemic	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-21	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7qwsyny	<NULL>	Diagnosis of idiopathic Parkinson´s disease confirmed by a movement disorders specialist in accordance with Parkinson’s Disease Society Brain Bank diagnostic criteria; both genders; age over 50 years; disease staging between 1.5 and 3 according to the modified Hoehn and Yahr scale; undergoing regular and stable pharmacological treatment; Mini-Mental State Examination score major ou equal to 24; no other associated neurological, musculoskeletal and/or cardiorespiratory diseases and the ability to walk independently; having a smartphone or computer and access to internet; knowledge about or available assistance on how to make video calls; and the ability to participate and provide written informed consent	Diagnosis of atypical Parkinson´s disease; neuropsychiatric comorbidities; inability to walk 10 meters; presence of severe dyskinesia that prevents the participant from sitting in a chair; not understanding any of the training protocol stages and experiencing severe pain and/or discomfort that precludes performing the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-2wcyvss	Plasticity in corticomotor pathways following a tooth-clenching task and masseter sensitization is impaired in bruxers compared to matched control individuals	Data analysis completed	Intervention	2022-04-20	<NULL>	<NULL>	5355	Could sensorimotor cortical excitability be modulated by simulated jaw function activity and hyperalgesia induced by intramuscular NGF administration	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-16	Aarhus University	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-2wcyvss	<NULL>	The volunteers participating in the study were in good general health; of both gender, aged less than 18 years; and with no orofacial pain complaints in the last 30 days or chronic pain disorders.	Presence of dental or medical illness; regular intake of medication such as antidepressants; anticonvulsants; or nonsteroidal anti‐inflammatories; any diagnosis of psychiatric or personality disorders; and the presence of contraindications to transcranial magnetic stimulation (i.e., metal implants in the head; implanted electronic devices; history of epilepsy and if they were pregnant) were defined as exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-102ydhjs	Homeopathy as an adjuvant treatment for patients with COVID-19 Associated Pneumonia	Data analysis completed	Intervention	2022-05-06	<NULL>	<NULL>	5383	Homeopathy as an adjuvant treatment for patients with COVID-19 - HU/UFSC	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-07-13	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani de São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-102ydhjs	<NULL>	Both genders; age between 20 and 70 years; positive test for SARS-CoV-2 by reverse transcription polymerase chain reaction or rapid antigen test; pneumonia, diagnosed according to clinical criteria, with or without imaging confirmation (plain radiographs, computed tomography angiography); Indication of hospital admission; no clinical condition that impairs verbal communication; homeopathy interview within 24 hours of admission.	Pregnancy, or women who had given birth up to 45 days earlier; hospital admission for palliative care; lower oxygen saturation 93 percent through an oxygen reservoir mask (criterion for admission to intensive care unit)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-3ydggrz	Development of a measure to help predict intubation difficulty Distance from skin to epiglottis	Data analysis completed	Observational	2022-06-08	<NULL>	<NULL>	5418	Development of a new measure to predict difficult airway obtained by ultrasound: cutaneous-epiglottic distance. observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-02	Universidade Estadual Paulista - UNESP	Fundação Centro Médico de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3ydggrz	<NULL>	Adult patients of both sexes who will undergo general anesthesia under tracheal intubation	Obese patients with a BMI greater than 35kg/m2, with obstructive sleep apnea, with a previous history of difficult tracheal intubation or who have any predictive sign of difficult intubation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-9ydn4bn	Influence of actn3 and ppar alpha gene variations on recovery from oxidative stress, muscle wastage and post-exercise physical performance in response to beetroot juice supplementation	Data analysis completed	Intervention	2022-06-09	<NULL>	<NULL>	5421	Influence of actn3 and ppar alpha gene polymorphisms on recovery from oxidative stress, muscle wasting and post-exercise physical performance in response to beetroot juice supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9ydn4bn	<NULL>	Runners for at least one year; be performing uninterrupted training for at least three months; train with the aim of participating in long-term running competitions.	Volunteers who had some chronic degenerative disease; smokers; who made continuous use of any medication; did not participate in all experimental procedures; presented gastrointestinal discomfort to beet juice or control drink.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-84r7q6r	Evaluation of blood glucose concentration and its effect on appetite and food consumption in healthy individuals	Data analysis completed	Intervention	2022-06-10	<NULL>	<NULL>	5424	Determination of the glycemic index and glycemic response of foods and their effect on appetite and food intake in eutrophic and euglycemic individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-84r7q6r	<NULL>	Normal-weight individuals (body mass index ranging from 18.5 to 24.9 kg/m² and body fat percentage from 12 to 20% for males and 20 to 30% for females) (Sociedad Española para el Estudio de la Obesidad, 2000); non-smokers; non-pregnant women or lactating women; and who present fasting glucose ranging from 70 to 99 mg/dl.	Type 1 or 2 diabetes; family history of first-degree diabetes mellitus; recent digestive, liver, kidney, cardiovascular, thyroid, or inflammatory diseases; alcohol intake greater than two doses (greater than 20 ml) per day; weight instability (gain or loss of more than 3 kg in the last 3 months); being on a diet to control weight; use medications that affect metabolism and have an allergy or aversion to the tested foods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-65zd2v4	Profile of patients with fecal leakage and suggestion of physiotherapeutic treatment for patients with bowel complaints and leakage of feces	Data analysis completed	Observational	2022-06-10	<NULL>	<NULL>	5427	"Constipation and Fecal Incontinence:
Phase I - Profile of patients complaining of constipation and fecal incontinence
Phase II - Elaboration and implementation of a physiotherapeutic treatment protocol in patients with constipation complaints"	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-05	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-65zd2v4	<NULL>	Study group: patients with complaints of constipation and patients with fecal incontinence; in the control group und without pelvic dysfunctions; everyone over 18 years old; who signed the Free and Informed Consent Term (ICF).	Individuals with cognitive impairment; individuals without constipation and fecal incontinence in the study group; in the control group individuals who had pelvic complaints. In both groups, individuals with: untreated respiratory diseases, visual alteration (without correction), acute vestibular and orthopedic alterations, practice of intense physical exercise (athletes).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-9ngb95	Effects of calcium supplementation in the prevention of preeclampsia in hypertensive pregnant women.	Data analysis completed	Intervention	2018-11-07	<NULL>	<NULL>	5448	Effects of calcium use to evaluate efficacy and safety in the treatment of pregnant women with gestational hypertension: randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-29	Universidade Federal de São Paulo	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-9ngb95	<NULL>	Pregnant women over 18 years of age; single fetus; primigravidae; diagnosis of gestational hypertension; overweight and/or obesity; be at least 20 weeks pregnant; low socioeconomic factor; low dietary calcium intake (less than 800mg/day); non-use of drugs that interfere with calcium absorption (corticosteroids; thiazides; thyroid hormones)	Pregnant women with polyhydramnios; severe anemia; fetal death; severe preeclampsia; history of hypertension before pregnancy; placental abruption; premature rupture of membranes; abnormal umbilical artery doppler; uteroplacental insufficiency; other pre-existing medical condition; any contraindication to calcium supplementation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-289hz3v	Effect of Brazil nut consumption as a source of selenium on the production of free radicals, inflammation and its relationship with a genetic polymorphism of glutathione peroxidase 1 in women with rheumatoid arthritis.	Data analysis completed	Intervention	2022-06-28	<NULL>	<NULL>	5453	Effect of Brazil nut supplementation (Bertholletia excelsa H.B.K.) as a source of selenium on oxidative stress markers, inflammatory cytokines, and their relationship with Pro198Leu polymorphism in the glutathione peroxidase 1 gene in patients with rheumatoid arthritis.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-07	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-289hz3v	<NULL>	Patients diagnosed with rheumatoid arthritis (criteria established by the American College of Rheumatology); pharmacological stability of at least 3 months; Healthy individuals with no diagnosis of rheumatologic and autoimmune diseases.	Not pregnant; not be in lactating period; not participating in another clinical trial; not using vitamin-mineral supplements (except calcium and vitamin D); not smoking; not abusing alcohol; not have diagnostic of cancer, thyroid, kidney diseases; not consuming Brazil nuts regularly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-2gj78z9	Comparative clinical study between treatment with papain gel 2% and 10% in patients with lower limb ulcers.	Data analysis completed	Intervention	2022-07-06	<NULL>	<NULL>	5467	Randomized double blind clinical trial, comparing treatment with papain gel 2% and 10% in patients with lower limb ulcers.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-08-29	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2gj78z9	<NULL>	Patients with lower limb ulcers; aged 18 or over; male or female; who agreed to participate voluntarily in the research	Patients under 18 years old; with ulcers with malignant transformation (cancer); arterial disease; osteomyelitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-5f426rx	Effects of using Colchicine for the prevention of inflammatory complications, arrhythmias and pain control in the postoperative period of cardiac surgery.	Data analysis completed	Intervention	2022-07-06	<NULL>	<NULL>	5470	Effects of Colchicine in the prevention of Post-pericardiotomy syndrome, pain control and occurrence of Atrial Fibrillation in the postoperative period of Cardiac Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de Santa Cruz do Sul	Universidade de Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5f426rx	<NULL>	Patients in post operative of cardiac surgery; both sexes; age 18 to 85 years.	Patients undergoing emergency cardiac surgery; presence of atrial fibrillation in the preoperative period; use of pacemakers; patients with chronic renal failure; patients undergoing treatment for endocarditis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-2sypq9j	Impact of daily energy shortage announcements on ICU calorie supply: a pragmatic trial	Data analysis completed	Intervention	2022-07-07	<NULL>	<NULL>	5471	Impact of daily enunciation of energy deficit on ICU heat supply: a pragmatic trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-23	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-2sypq9j	<NULL>	Adults and seniors, aged 18 years or over; both sexes; being on mechanical ventilation or being intubated within 48 hours of admission; being receiving or starting to receive enteral nutritional therapy within 48 hours of admission; present a diagnosis that possibly requires enteral nutritional therapy for more than 7 days	Subjected to supplemental or total parenteral nutritional therapy in the initial 7 days; submitted to major digestive surgeries; history of short bowel syndrome, inflammatory bowel disease, previous recurrent record of diarrhea; admitted with major digestive bleeds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-7kqqqxn	Evaluations in intellectual disabled in the pre-sport program of Hippotherapy	Data analysis completed	Intervention	2022-07-08	<NULL>	<NULL>	5472	Impact of the pre-sporting program for hipppotherapy on posture, strength, balance and electrical activity in individuals with intellectual disabilities	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-29	Universidade Federal do Triângulo Mineiro	Associação de Pais e Amigos dos Excepcionais de Uberaba - APAE	https://ensaiosclinicos.gov.br/rg/RBR-7kqqqxn	<NULL>	Individuals with fifteen years old and maximum twenty years old; both genders; be regularly enrolled at APAE/Uberaba-MG; ability to understand verbal commands and medical diagnosis of intellectual disability; informed Consent Form signed by parents and/or guardians	uncontrolled seizures; spinal instability; herniated disc; shoulder and/or hip dislocations; scoliosis above 30 degrees; acute rheumatic processes; acute heart disease; hydrocephalus with valve or associated syndromes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-2fkzb2s	Effect of acupuncture with electrical stimuli and therapy with games in elderly with knee arthrosis	Data analysis completed	Intervention	2022-07-12	<NULL>	<NULL>	5481	Effect of Electroacupuncture and Wii therapy on functional performance and inflammatory parameters in elderly with knee osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2fkzb2s	<NULL>	Be 60 years of age or older;Have a diagnosis of osteoarthritis in at least one knee, based on the American College of Rheumatology clinical and radiographic criteria (Hinton, et al. 2002); with classification II, III or IV in the classification grades of Kelgreen and Lawrence (Kelgreen &amp; Lawrence, 1657);Have symptoms for knee osteoarthritis with scores equal to or greater than two on the visual analogue pain scale (VAS);Not having undergone any surgical procedure on the lower limbs;Not having had recent trauma to the knees;Not having undergone physical therapy treatment or any other rehabilitation procedure in the last three months;Present minimal clinical and cognitive conditions to perform physical activities;Not using glucocorticoids for at least two months.	Elderly people with knee or hip arthroplasty; Acute orthopedic, neurological, respiratory or cardiac diseases that prevent them from performing the proposed exercise; Cognitive deficit suggested by a lower score than those compatible with their education when performing the Mini Mental State Examination (for illiterate people the score is 13; for schooling between one to three years, 18; for schooling between four to seven years, 23; for schooling over seven years, 26) (BERTOLUCCI et al., 1994); Vestibular disorders; Immunosuppressed or immunodeficient .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-5yhsrrz	Physiotherapy with biofeedback after knee surgery	Data analysis completed	Intervention	2022-07-14	<NULL>	<NULL>	5484	Knee rehabilitation after meniscectomy: The influence of electromyographic biofeedback in a physiotherapy program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-22	Escola Superior de Saúde do Alcoitão	Escola Superior de Saúde do Alcoitão	https://ensaiosclinicos.gov.br/rg/RBR-5yhsrrz	<NULL>	Both genders; Age between 18 and 55; underwent arthroscopic partial meniscectomy less than two weeks before beginning physiotherapy	Concomitant anterior cruciate ligament injury; osteoarthritis greater than grade II; previous surgeries in the ipsilateral knee; unconsolidated fractures; partial or total amputation in upper or lower limbs; permanent or temporary dysfunctions of the central or peripheral nerve system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-268y2t4	Treatment of dental implant disease	Data analysis completed	Intervention	2022-07-21	<NULL>	<NULL>	5502	Comparative Study of Different Techniques for the treatment of periimplantitis disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-268y2t4	<NULL>	Included patients must have gingival bleeding around the implant, bone loss around the implant and the implant must have been in masticatory function for more than 01 year, patient of both sexes aged between 18 and 80 years, non-smokers, not using of systemic medication and patients should not be pregnant or lactating.	Excluded patients must not present: gingival bleeding around the implant, bone loss around the implant and the implant must not have been in mastication for more than 01 year, aged below 18 years or above 80 years, smokers, with use of systemic medication and pregnant and lactating patients, history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-97ndkq7	Effect of caffeine on weight and physical performance	Data analysis completed	Intervention	2022-07-25	<NULL>	<NULL>	5507	Effect of mouthwash with nutritional products containing caffeine on the immunometabolic profile and physical performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-97ndkq7	<NULL>	Man; physically active; experience with resistance training for at least 2 months; equal or greater than 18 years; availability of time and transportation	Smoker; Illnesses; Inflammatory process; Injury to lower or upper limbs; caffeine allergy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-8mb3ws4	Dental care of critical patients and its influence on the modulation of the oral bacterial microbioma	Data analysis completed	Intervention	2022-07-25	<NULL>	<NULL>	5508	Analysis of the salivary microbiome of critically ill patients and its relationship with nutritional status and antibiotic resistance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-07	Universidade do Oeste de Santa Catarina	Hospital Unimed de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-8mb3ws4	<NULL>	patients admitted to the Intensive Care Unit; on mechanical ventilation; older than 18 years	patients who had a current diagnosis and/or salivary gland disorders (Sjogren&apos;s syndrome, salivary gland tumor, parotitis); cancer patients regardless of the stage of the disease, psychiatric patients,; postoperative discharge within the first 24 hours; patients admitted from other institutions already on mechanical ventilation and oral and maxillofacial trauma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-8js7t83	Ingestion of probiotics (a Lactobacillus rhamnosus formula) as complementary therapy in the treatment of patients with plaque psoriasis (an inflammatory disease of the skin)	Data analysis completed	Intervention	2022-08-02	<NULL>	<NULL>	5528	Use of a Lactobacillus rhamnosus formula as adjuvant in the treatment of plaque psoriasis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-20	Enrico Stefano Suriano	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8js7t83	<NULL>	Being over 18 years old; having plaque psoriasis.	Being pregnant; having other skin diseases, neoplasms or systemic inflammatory diseases (such as Crohn’s disease, inflammatory bowel disease, vasculitis and sarcoidosis).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-9h2kdm9	Comparison of pain levels in nasopalatine nerve blocks using two different techniques	Data analysis completed	Intervention	2022-08-15	<NULL>	<NULL>	5550	Comparison of pain levels in nasopalatine nerve blocks using two different techniques	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9h2kdm9	<NULL>	Both genders; age between 18 and 30 years; any ethnicity; any marital status; any nationality; any place of birth; with previous experience of local anesthesia without intercurrences; not having undergone infiltrative anesthesia in the region in the two weeks prior to the study; and not having used any medication capable of altering pain perception in the two weeks prior to the study	Age lower than 18 years or higher than 30 years old; pregnant or lactating women; history of hypersensitivity to the drugs used in the study; alcohol abuse or drug dependence; psychiatric disorders or systemic diseases; being under treatment with CNS-acting drugs; use of drugs capable of altering pain perception in the two weeks preceding the study; and moderate anxiety or higher (over 9), based on Corah&apos;s Dental Anxiety Scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-36qz3p	Evaluation of the efficacy of simvastatin use in Systemic Sclerosis patients: A Randomized Clinical Trial	Data analysis completed	Intervention	2019-09-30	<NULL>	<NULL>	5552	Evaluation of the Effectiveness of Simvastatin Use in Systemic Sclerosis Patients: A Pragmatic Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Sociedade Brasileira de Reumatologia	Hospital das Cllinicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-36qz3p	<NULL>	Diagnosis of Systemic Sclerosis according to the American College of Rheumatology; minimum and maximum age between eighteen and seventy years of age; serum total cholesterol levels up to 200mg/dl; written consent to participate in the study	Pregnant women; intolerance or allergy to simvastatin or its derivatives; being in use or having used it for less than 30 days; diabetes mellitus; heart failure; renal failure; hypertension; myopathies; hypothyroidism; smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7f4jy8j	Effects of Manual Techniques applied to the cervical spine on the nervous system of the elderly	Data analysis completed	Intervention	2022-08-22	<NULL>	<NULL>	5566	Effects of Osteopathic Manipulative Treatment (OMT) on the functionality of patients with Congestive Heart Failure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7f4jy8j	<NULL>	Age equal to or greater than 60 years; physically active; normotensive	Subjects unable to remain in the stand up position for at least 10 minutes; patients with rheumatological diseases; subjects with acute and/or chronic joint pain; subjects with cardiovascular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-6zw2fnb	Determination of glycemic response to the consumption of two specialized formulas for glycemic control	Data analysis completed	Intervention	2022-08-31	<NULL>	<NULL>	5586	Glycemic response of individuals to the consumption of formula for enteral nutrition	<NULL>	1, n/a, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-16	Prodiet Medical Nutrition	Food Research Center (Fundação de Amparo à Pesquisa do Estado de São Paulo) / Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6zw2fnb	<NULL>	Healthy volunteers; aged between 18 and 49 years; both genders; with good health conditions according to a report of absence of diabetes, renal and gastrointestinal diseases and hyperthyroidism; having a Body Mass Index (BMI) within the normal range of 18.5 to 24.9 kg/m²; with normal glucose tolerance (between 70 and 99 mg/100 mL in the morning, after fasting for 10 hours) and maximum postprandial blood glucose of 140 mg/100 mL and close to fasting after 2 hours	Volunteers using any type of medication that could affect digestion and absorption of food (antibiotics, medications for diarrhea and constipation) during the study period; hormone therapy; presence of pregnancy or breastfeeding; family history of diabetes; significant glycemic variations in the glycemic response test to the reference food	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-4jk8mk7	Evaluation of the metabolic profile of saliva and plasma associated with Periodontitis in obese and normal weight pregnant women and of proteins differentially expressed in the saliva of these women before and after delivery	Data analysis completed	Observational	2022-09-20	<NULL>	<NULL>	5617	Evaluation of the metabolic profile of saliva and plasma associated with Periodontitis in obese and eutrophic pregnant women and of proteins differentially expressed in the saliva of these women in pre and post term	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-09	Faculdade de Odontologia de Bauru - Universidade de São Paulo	King's College London	https://ensaiosclinicos.gov.br/rg/RBR-4jk8mk7	<NULL>	Be between 18 and 40 years old; during the 3rd trimester of pregnancy, between the 27th and 39th gestational week; with regular follow-up with the obstetrician; with adequate cognitive function during pregnancy; with no problem that required absolute rest	Twin pregnancies; individuals with neuromotor impairments; arterial hypertension during pregnancy; Gestational Diabetes Mellitus; malnutrition; overweight, therefore, body mass index between 25.00 and 29.99 kg/m2; confirmed or suspected diagnosis of SARS-CoV-2 infection; hyposalivation; subjects who were using or who used at some point in pregnancy antibiotics or any medication that could interfere with periodontal status or salivary flow, e.g. immunosuppressive drugs, anticonvulsants or calcium channel blockers; who were under orthodontic treatment or any dental treatment with another professional; with multiple tooth loss, so more than two teeth per hemiarch; self-reported systemic disease besides obesity; and users of alcohol, tobacco, and illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-2xwgc74	Evaluation of saliva and plasma metabolites associated with Periodontitis in obese and normal weight pregnant women and saliva proteins of these women during pregnancy and after delivery	Data analysis completed	Observational	2022-09-23	<NULL>	<NULL>	5633	Evaluation of the metabolic profile of saliva and plasma associated with Periodontitis in obese and eutrophic pregnant women and of proteins differentially expressed in the saliva of these women in pre and post term	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-07	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xwgc74	<NULL>	Pregnant women aged 18–40 years; who were in the 3rd trimester of pregnancy, between 27th and 39th gestational weeks; with regular follow-up with the obstetrician; and who had adequate cognitive function during pregnancy, without impairments that required absolute rest	Twin pregnancy; individuals with neuromotor impairment; arterial hypertension during pregnancy; Gestational Diabetes Mellitus; malnutrition; overweight, therefore, BMI between 25.00 and 29.99 kg/m2; confirmed or suspected diagnosis of SARS-CoV-2 infection; with hyposalivation; subjects who were using or who used at some point in pregnancy antibiotics or any medication that could interfere with periodontal status and/or salivary flow, e.g., immunosuppressive, anticonvulsant or calcium channel-blocking drugs, such as cyclosporine, phenytoin or nifedipine, respectively; who were under orthodontic treatment or any dental treatment with another professional; participants with cavitated caries lesions; with severe dental wear; with diagnosis of stages I and IV of periodontitis; with multiple tooth loss, being more than two teeth per hemiarch; with self-reported systemic disease besides obesity; and users of alcohol, tobacco, or illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-6x8bx3y	Management of minor illness: impact of pharmaceutical training based on clinical guidelines	Data analysis completed	Intervention	2022-10-11	<NULL>	<NULL>	5658	Pharmacy-based: elaboration, updating and implementation of clinical pharmaceutical care guidelines for self-limiting health problems	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-30	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6x8bx3y	<NULL>	Participants of the expert panel of the validation stage: minimum score of 5 points in multi-criteria evaluation; Pharmacists in the stages of training and use of clinical guidelines: graduation in Pharmacy; Work in Community Pharmacy; Patients who evaluated pharmaceutical care: having a self-limiting health problem in one of the themes of the clinical guidelines; Be over 18 years old	Participants who are not available to participate will be excluded from the project; Be under 18 years of age; Fail to respond to contacts established by researchers after 3 consecutive attempts, made 3 business days apart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3vh8zgj	Creatine supplementation plus resistance training in adults	Data analysis completed	Intervention	2022-10-14	<NULL>	<NULL>	5663	Effect of Creatine Monohydrate Supplementation in association with Strength Training with Blood Flow Restriction on strength and muscle mass gain in untrained men	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3vh8zgj	<NULL>	Male participants between eighteen and thirty years of age	Volunteers who have a body mass index below eighteen and above twenty-four; or those who, of their own free will, no longer want to participate in the study; do not attend training and collection sites on scheduled days; Have participated in strength training in the past six months; having used a food supplement or ergogenic medication for at least two years before the study; smoking or drinking alcohol at least a week before tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-4z9fcn7	Study to Evaluate Nutritional Counseling to Prevent Excessive Weight Gain During pregnancy in Pregnant Women at Instituto Fernandes Figueira Fiocruz Rio de Janeiro between 2020 and 2021	Data analysis completed	Intervention	2022-10-19	<NULL>	<NULL>	5670	A Clinical Trial to Evaluate Nutritional Counseling in Preventing Excessive Gestational Weight Gain in Pregnancy at Antenatal Care of Instituto Fernandes Figueira Rio de Janeiro between 2020 e 2021	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-29	Lizanka Paola Figueiredo Marinheiro	Instituto Fernandes Figueira- IFF Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-4z9fcn7	<NULL>	Patients over 18 years of age (complete by the day of study entry); gestational age less than or equal than 20 weeks (defined by ultrasound); Patients with BMI &gt; 18.5kg/m² singleton pregnancy	fertility assisted  pregnancy; uncontrolled hypertension; recently diagnosed thyroid disease (&lt; 30 days); history of eating disorder; bariatric surgery; mental illness;  drug or alcohol use disorder; severe gastrointestinal disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-92q4qqw	Effects of Tissue Flossing and Neural Mobilization Techniques on Ankle of Adolescent Basketball Athletes	Data analysis completed	Intervention	2022-10-25	<NULL>	<NULL>	5680	The Effects of Tissue Flossing Techniques and Neural Mobilization on Ankle Range of Motion and Performance of Adolescent Basketball Athletes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-12	Universidade de Estado de Santa Catarina	Universidade de Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-92q4qqw	<NULL>	Male subjects; adolescent athletes of the Florianópolis basketball team; healthy; aged between 13 and 17 years; and with at least 6 hours of basketball training per week	Lower limb injury in the last 3 months; history of neurological or orthopedic disease that has affected lower limbs and makes them unable to perform the proposed tests; history of chronic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-8hcg2c	Does the method of tooth isolation influence the longevity of restorations?	Data analysis completed	Intervention	2020-01-06	<NULL>	<NULL>	5698	Does ruber dam isolation increases the longevity of restorations of primary molars? A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8hcg2c	<NULL>	Patients aged 3 to 9 years old who have at least one class I or II caries lesion in deciduous molars; 198 teeth; who radiographically have at least two thirds root, and lesions D1 and D2, where restorative treatment is indicated. E1 Radiolucidity in the outer half of enamel; E2 Radiolucidity in the inner half of enamel; D1 Radiolucidity in the external third of dentin; D2 Radiolucidity in the middle third of dentin; D3 Radiolucidity in the internal third of dentin.	spontaneous pain; fistula; mobility not compatible with the period of root resorption; advanced rhizolysis more than 2/3 of root resorption; participants who were included in the course were not included in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-93x9vcb	Clinical study of two root filling materials in treating a vital pulp of deciduous tooth	Data analysis completed	Intervention	2022-11-03	<NULL>	<NULL>	5699	Double-blind randomized clinical trial of the performance of two root filling materials in biopulpectmies of primay molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-04	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-93x9vcb	<NULL>	First or second deciduous lower molar with deep caries and pulp vitality; provoked or spontaneous pain that does not relieve with the use of medication; in case of teeth with provoked pain, absence of hemostasis in adequate time up to 5 minutes, after attempted pulpotomy; absence of fistula or abscess; absence of bone rarefaction on radiographic examination; absence of internal or external resorption of more than two thirds of the root; tooth restorative possibility	Children with difficult behavior and who do not cooperate with the treatment; children who have systemic health problems; teeth with periapical lesion or interradicular bone rarefaction; internal and or external resorption involving more than one thirds of the root length; teeth with less than two thirds of the root remainder; rupture of the pericoronary sac; restorative impossibility; teeth that have had some kind of previous pulp treatment; patients using antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-8qby2wt	Effects of a remotely supervised Home-based Program, during the Covid-19 pandemic, on the Functional Capacity and Cognitive Function of community-dwelling elderly: a randomized clinical trial	Data analysis completed	Intervention	2021-05-08	<NULL>	<NULL>	5779	Effects of a remotely supervised Home-based Program, during the Covid-19 pandemic, on the Functional Capacity and Cognitive Function of community-dwelling elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal Rural de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8qby2wt	<NULL>	Volunteers with self-sufficient visual and auditory capacity; at least one electronic device that has a front camera; Internet access; relative or guardian available to assist in interventions	Decompensated health diagnoses, high-risk cardiovascular diseases, grade four or five knee osteoarthritis, taking medication that may compromise mobility, functionality and cognition; neurodegenerative diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-10vtd55m	Assessment of pain caused by respiratory therapy in children after heart surgery	Data analysis completed	Intervention	2022-12-29	<NULL>	<NULL>	5786	Assessment of pain caused by respiratory therapy in children with congenital heart disease after surgery	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-01-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10vtd55m	<NULL>	Children with congenital heart disease; both genders; age between 0 and 18 years; undergoing heart surgery	Parental request; intraoperative death; hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-7vyw8p	Effectiveness of a Novel Multicomponent Treatment in patients with Fibromyalgia: Clinical study	Data analysis completed	Intervention	2019-06-05	<NULL>	<NULL>	5799	Effectiveness of a Novel Multicomponent Treatment versus Conventional Treatment in patients with Fibromyalgia: Randomized clinical trial, single blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Universidad Gabriela Mistral	Universidad de las Americas	https://ensaiosclinicos.gov.br/rg/RBR-7vyw8p	<NULL>	Women subjects whose age range from 18 to 60 years derived to the rehabilitate foundation with medical diagnosis of fibromyalgia based on the criteria of the American College of Rheumatology; subjects reporting moderate pain of at least 4/10 EVA; subjects who can read, write and follow basic instructions in Spanish; subjects that accept and sign the informed consent.	Women in stages of pregnancy and / or lactation; women with chronic oncological pain; women with metabolic disorder and / or uncontrolled comorbidities and who present some psychiatric or cognitive alteration that prevents them from participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-9n4sn5m	Effects of 12-hour overnight fasting on metabolism and quality of life in overweight middle-aged women	Data analysis completed	Intervention	2023-01-05	<NULL>	<NULL>	5801	Metabolic responses of overweight/obesity climacteric women according to feeding times	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE	Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-9n4sn5m	<NULL>	Female individuals; aged between 40 and 59 years; body mass index (BMI) between 25 kg/m2 and 39.9 kg/m2; waist circumference above 88 centimeters	Women with previous diagnosis of changes in the thyroid gland; impaired liver function; impaired kidney function; cardiovascular diseases; cancer; serious illness; using medication that alters weight; diagnosed with psychiatric illnesses. In addition, they will also be deleted; gastrointestinal problems; using drugs that may interfere with body composition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-5398927	Effect of online brief intervention to reduce alcohol use during the COVID-19 pandemic: a non-randomized clinical trial	Data analysis completed	Intervention	2023-01-05	<NULL>	<NULL>	5802	Feasibility and effectiveness of brief online interventions to reduce alcohol use among youth and adults during the COVID-19 pandemic: a randomized clinical trial	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5398927	<NULL>	Be 18 years of age or older; both sexes; and agree to participate in all stages of the research	Pregnant women; people with difficulty accessing the internet or mobile phone; incomplete questionnaires; and participants in the pilot study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-98v2y84	Effectiveness of technology&apos;s use for the management and control of type 2 Diabetes Mellitus. Study in a population residing in Complexo do Alemão, Rio de Janeiro	Data analysis completed	Intervention	2023-01-10	<NULL>	<NULL>	5810	Effectiveness of an Educational System and Remote Data Collection of patient information by Mobile Devices and the Internet in the metabolic control of type 2 Diabetes Mellitus A controlled study in a population residing in Complexo do Alemão, Rio de Janeiro	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-05	Hospital Universitário Pedro Ernesto	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-98v2y84	<NULL>	The study selected participants with a previous diagnosis of type 2 diabetes according to the American Diabetes Association criteria. Adults aged between 18 and 75 years; with a previous diagnosis of type 2 diabetes or fasting blood glucose &gt;126 mg/dL and/or random blood glucose &gt;200 mg/dL; under non-pharmacological treatment; oral antihyperglycemic agents or insulin use were included. All the participants received free internet access during the study. Thus, it was considered inclusion criteria to live in areas with available cabling for the establishment of an internet connection, which was provided by the study group	Patients with type 1 diabetes; other types of diabetes; and pregnant women were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-98nzfnq	Effects of Lower Limb Resistance Training with different planning models on Strength and Lean Mass of military personnel	Data analysis completed	Intervention	2023-01-13	<NULL>	<NULL>	5818	Comparison between the effects of Periodized Strength Training Programs, Machine versus Free Weight, on parameters of neuromuscular fitness in Brazilian Army militaries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Instituto de Pesquisa da Capacitação Física do Exército - IPCFEx	Escola de Educação Física e Desportos da Universidade Federal do Rio de Janeiro - EEFD/UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-98nzfnq	<NULL>	have answered negatively to all the sentences of the Physical Activity Readiness Questionnaire (PARQ); be a member of the Brazilian Army;  be between 18 and 26 years old; not having had any type of musculoskeletal injury for at least the last six months; male individuals	not being able to fully implement the predicted protocols; not being able to participate in the intervention due to medical recommendations; missing 3 (three) training sessions; make use of medications and/or supplements that may interfere with the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-5p8nzk6	Treatment of COVID-19 sequelae with Physical Exercises	Data analysis completed	Intervention	2020-11-25	<NULL>	<NULL>	5819	Respiratory Rehabilitation in survivors of COVID-19 - a clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-26	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5p8nzk6	<NULL>	Subjects over 18 years of age diagnosed with COVID-19 in the last six months; with at least one of the following symptoms, shortness of breath, tiredness, muscle pain, joint pain and cough.	Patients with previous respiratory diseases such as asthma, chronic obstructive pulmonary disease, or pulmonary fibrosis; Patients with NYHA III or IV heart disease; Patients with neurological or osteoarticular diseases that limit participation in the study; Patients with difficulty understanding to perform the study tests; Patients with symptoms and cardiac alterations that contraindicate physical exertion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-2rgxbdv	Effect of Immunological Reactions of Dexmedetomidine when used in patients undergoing Video-Assisted Gallbladder Removal	Data analysis completed	Intervention	2022-03-28	<NULL>	<NULL>	5833	Immunomodulatory effect of Dexmedetomidine as an adjuvant drug in patients undergoing laparoscopic Cholecystectomy	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2022-04-01	Gustavo Nascimento Silva	Hospital Universitário Gaffree e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-2rgxbdv	<NULL>	Patients classified as physical health status 1 and 2; Laparoscopic Cholecystectomy Surgery; Patients who signed the Free and Informed Consent Form	Patients classified as physical health status more than 2 ;Conversion to open surgery;Emergency Surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-97kx5jv	An Alksite Composite material to Restore Endodontically Treated Teeth: A randomized control trial study	Data analysis completed	Intervention	2023-01-19	<NULL>	<NULL>	5835	Evaluation of a Bioactive Composite for the Restoration of Endodontically Treated Teeth: A Prospective Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo - FORP USP	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo - FORP USP	https://ensaiosclinicos.gov.br/rg/RBR-97kx5jv	<NULL>	Both genders; Presence of 1 lower molar (First or Second) treated endodontically requiring direct restoration; Endodontic treatment performed for a maximum of 6 months; Presence of antagonist tooth in the dental arch; No parafunctional habits; No temporomandibular disorder; age 18 to 40 years	Teeth with extensive loss with indication of indirect restorations were excluded from the study; teeth with root involvement such as fractures or cracks, patients with poor oral hygiene, patients with chronic or aggressive periodontitis, teeth that were endodontically treated for more than 6 months and teeth without provisional cavity sealing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-58q5y2m	Methylpredniprednisolone on ICU patients with COVID-19 on mechanical ventilation	Data analysis completed	Intervention	2023-01-24	<NULL>	<NULL>	5840	Evaluation of Methylprednisone use in patients with Acute Respiratory Syndrome by COVID-19	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-07-07	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-58q5y2m	<NULL>	over 18 years old ; COVID-19 ; mechanical ventilation within 24 hours; Acute Respiratory Distress Syndrome	pregnancy; active lactation; history of methylprednisolone allergy; corticosteroid use in the past 15 days; informed consent refusal; expected death in the next 24 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-4n6rqyj	Device Development for a Diagnostic Procedure in Liver Diseases	Data analysis completed	Intervention	2023-02-02	<NULL>	<NULL>	5858	Development of a Device for Performing Biopsy Video-Assisted Liver	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Instituto para O Desenvolvimento da Educação Ltda.	Instituto para O Desenvolvimento da Educação Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4n6rqyj	<NULL>	Patients with moderate to severe hepatic steatosis, submitted to abdominal laparoscopic surgery for another underlying disease; Patients who needed a liver biopsy for etiological confirmation or staging of disease activity	Refusal to participate in the study: Patients diagnosed with hepatocellular carcinoma (HCC) AND The following risk factors: Patients with INR &gt; 1.8 and/or platelets &lt; 70,000/mm3; Patients diagnosed with hepatocellular carcinoma (HCC); Patients with coagulopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-103yt9mm	Facelift surgery in post-bariatric surgery patients	Data analysis completed	Intervention	2023-02-03	<NULL>	<NULL>	5861	Rhytidectomy with and without SMAS plicature in post-bariatric surgery patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Escola Paulista de Medicina	Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-103yt9mm	<NULL>	Female patients; aged between 40 and 70 years-old; post-bariatric surgery; with stable weight for at least 3 months; presenting with complaints of rhytidosis and skin sagging in the face.	Patients previously submitted to facial surgery; implants or cosmetic procedures (either physical or chemical in the last 12 months); recent or uncontrolled clinical conditions (such as diabetes and hypertension); disorders of wound healing; autoimmune or collagen disorders; psychiatric conditions, smokers; patients in use of anticoagulant medications; corticosteroids; history of hypersensitivity to anesthesia; illiteracy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-2t7pt25	Effects of different Physical Exercise interventions performed at home on physical conditioning, physical activity level and aspects related to the quality of life of the elderly	Data analysis completed	Intervention	2023-02-13	<NULL>	<NULL>	5901	Effects of different Physical Exercise interventions performed remotely on physical fitness, physical activity level and aspects related to the quality of life of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-26	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2t7pt25	<NULL>	Participants must be men and women between the ages of 60 and 70; not practicing physical exercises regularly and systematically for at least twelve months; be a resident of the State of Rio Grande do Sul; have internet access and device for video calling	Smokers; uncontrolled cardiovascular disease; no internet access; any musculoskeletal problems that prevent physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-5spbfz7	Online Group Therapy for weight regain patients after Stomach Reduction Surgery	Data analysis completed	Intervention	2023-02-22	<NULL>	<NULL>	5915	Cognitive Behavioral Intervention in patients who experience weight regain after Bariatric Surgery: a group and online Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-05	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5spbfz7	<NULL>	volunteers of both genders; having performed bariatric surgery more than 2 years ago; age between 18 and 65 years; with a 15% increase in total weight from the lowest weight achieved (nadir)	inability to access the internet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-2qbpczv	Evaluation of a Rapid Salivary Test in Patients with Periodontitis with and without Sistemic Diseases	Data analysis completed	Intervention	2023-02-23	<NULL>	<NULL>	5921	Evaluation of a Rapid Test for Total Saliva Protein in Periodontal Patients with and without Comorbidities	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-20	Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto	Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2qbpczv	<NULL>	Minimum of 14 natural teeth (at least 10 posterior); periodontitis diagnosis; Systemically healthy patients; patients diagnosed with diabetes or rheumatoid artrhitis	Smoking, pregnancy; total edentulism; recent periodontal treatment; recent use of antibiotics; patients who refused to sign the Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8pjzmsp	Effect of Electrical Brain Stimulation on Pressure, Volume and Brain Activity in Stroke Patients	Data analysis completed	Intervention	2023-03-06	<NULL>	<NULL>	5936	Effect of Transcranial Direct Current Stimulation on Intracranial Pressure and Brain Electrical Activity in the Acute Phase of Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-18	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8pjzmsp	<NULL>	Individuals over 18 years of age; diagnosed with first stroke confirmed by computed tomography or magnetic resonance imaging; ischemic or hemorrhagic; with up to 72 hours of admission; individuals with severe impairment of motor skills, speech or affectivity, the family member/caregiver must express consent as the person legally responsible for the participant by signing the Free and Informed Consent Form.	Individuals with more than 72 hours of admission; clinically unstable; individuals with any metal in the cranial cavity; pacemakers or implanted defibrillators; individuals with lesions in the electrode placement area; without conditions or refusal by the participant or family member to provide informed consent by signing the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-9wwp8kp	Effect of Physical Exercise in older adults with Pulmonary Disease from Manizales	Data analysis completed	Intervention	2023-03-22	<NULL>	<NULL>	5955	Effect of Physical Training Intervention on the muscular function of elderly adults with Chronic Obstructive Pulmonary Disease from Manizales	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Universidad Autónoma de Manizales	Alcaldía de Manizales	https://ensaiosclinicos.gov.br/rg/RBR-9wwp8kp	<NULL>	Residents of Manizales, Colombia; aged over 50 years; diagnosis of Chronic obstructive pulmonary disease (COPD) (GOLD I-IV) confirmed by spirometry; evidence of a Forced Expiratory Volume in the first second (FEV1) / Forced Vital Capacity (FVC) ratio less than 70	Diagnosis of known respiratory disorders other than Chronic Obstructive Pulmonary Disease (COPD); history of significant inflammatory disease; malignancy; coronary disease; carrier of osteosynthetic material; partial or total limb amputation; neuromuscular, orthopedic and/or medical disease that impedes or physical exercise; CPOD exacerbation in the four weeks prior to inclusion; recent surgery and participation in pulmonary rehabilitation programs or physical exercises in the last year	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-5vzynf3	Homeopathic medicine and covid-19 pandemic: a prospective cohort study in Rio de Janeiro	Data analysis completed	Intervention	2023-03-29	<NULL>	<NULL>	5970	Use of homeopathic therapy during the covid-19 pandemic in health units in Rio de Janeiro	<NULL>	1-2, n/a, open	1-2	<NULL>	<NULL>	<NULL>	2020-05-01	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	Faculdade de Farmácia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5vzynf3	<NULL>	Women and men aged 18 years or older with or not COVID-19 influenza-like symptoms were included in this study	The exclusion criterion was a severe acute respiratory syndrome that leads to hospitalization by primary care teams	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-2ft3bxw	Thermal monitoring of the Achilles tendon during static and dynamic exercise associated with the application of light therapy	Data analysis completed	Intervention	2023-03-30	<NULL>	<NULL>	5977	Thermomonitoring of the Achilles tendon during Isometric and Eccentric exercise associated with Photobiomodulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-15	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2ft3bxw	<NULL>	Subjects of both genders; healthy; aged between 18 and 35 years; physically active according to the International Physical Activity Questionnaire classification; who do not have cardiorespiratory, osteomioarticular or neurological diseases that affect the ability to exercise; do not have tendinopathies, ruptures or history of Calcaneal Tendon surgeries; not be diabetic, hypertensive or have varicose veins or arterial and vascular diseases in the calf region	Volunteers who in the evaluation report pain on palpation of the calcaneal tension; those who were unable to complete the exercise protocol; those who during the intervention period present some systemic disease; not perform any of the pre-established assessments in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-4mx6m8z	Use of an educational program for the care of elderly people at risk of frailty	Data analysis completed	Intervention	2023-04-03	<NULL>	<NULL>	5980	Educational Program for elderly at risk of Fragility	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4mx6m8z	<NULL>	Elderly; be between 60 and 74 years old; assisted in the selected Basic Health Units; with preserved cognitive ability according to the Mini-Mental State Examination.	Elderly people with hearing, visual or speech deficits that prevented the application of the instruments; vulnerable elderly people who had sequelae that influenced daily life activities; history of lower extremity and/or spinal fractures in the last six months; closed medical diagnosis of mental disorder; elderly people participating in another educational health intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-7k2hpj4	Use of Mobile App for vaginal area exercises for women who lose urine during the Coronavirus pandemic	Data analysis completed	Intervention	2023-04-11	<NULL>	<NULL>	5993	Use of Mobile App for pelvic floor muscle training in women with Urinary Incontinence during the Coronavirus pandemic	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Estadual de Campinas	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-7k2hpj4	<NULL>	Women with urinary incontinence; age above 18 years; women who have a cell phone with an Android operating system; know how to read and write	Neurological problems that compromise understanding for the practice of exercises, or suggestive of neurogenic bladder; proven or suspected pregnancy; prior treatment for urinary incontinence; pelvic radiotherapy; up to one year after giving birth; three or more lower urinary tract infections in the last 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-104827wm	Influence of Color Application on Elementary School Students-3rd to 5th grade	Data analysis completed	Intervention	2023-04-18	<NULL>	<NULL>	6022	Influence of Chromatic Stimuli on Elementary School students-Cycle I	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-04	Harumi Falanga Duque	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-104827wm	<NULL>	Healthy volunteers; normal acuity or corrected visual acuity	Volunteers with moderate chromatic alterations (protanomaly or deuteranomaly), strong (protanopia or deuteranopia) and achromatopsia; carriers of diseases or administering medication that could alter color vision; volunteers with a compromised emotional history; with a recent ocular surgical history; volunteers in which those responsible authorized them, however, they did not feel free to participate.In this sense, in addition to the authorization of those responsible for the volunteers, the children&apos;s choice to participate or not was also considered and respected	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-38hjyt3	Auriculotherapy in Stress reduction in primary care health professionals	Data analysis completed	Intervention	2021-03-23	<NULL>	<NULL>	6030	Auriculotherapy to reduce occupational stress in primary care health professionals during the COVID-19 pandemic: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade do Estado da Bahia, Departamento de Ciências da Vida	Universidade do Estado da Bahia, Departamento de Ciências da Vida	https://ensaiosclinicos.gov.br/rg/RBR-38hjyt3	<NULL>	Volunteers with a stress level above the cutoff point; both genders; have completed the proposed questionnaires and scales; age between 18 and 70 years.	Participants on vacation or leave during the survey period; pregnant women; medical diagnosis of depression; medical prescription of antidepressants; having undergone auriculotherapy treatment in the last three months; have done some training in auriculotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-6fgnsqr	Electrical Brain Stimulation and its benefits for Chronic Kidney Patients on Hemodialysis	Data analysis completed	Intervention	2022-10-04	<NULL>	<NULL>	6034	Transcranial Direct Current Stimulation and its therapeutic potential in patients with Chronic Kidney Disease in Hemodialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6fgnsqr	<NULL>	Age between 18 and 75 years; previous medical evaluation with clinical diagnosis of depression; anxiety; chronic pain and pressure lability and being on hemodialysis treatment	Evidence of any cognitive deficit (senile dementia, Alzheimer&apos;s); presence of physical and / or organic difficulties; individuals with severe cardiovascular risk or hemodynamically unstable; history of seizures or epileptic disease; pregnancy; metallic implants in the head or neck and cardiac pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-10h5gd44	Use of Scintigraphy in the evaluation of the response to Renal Denervation in patients with treatment-resistant hypertension	Data analysis completed	Intervention	2023-05-05	<NULL>	<NULL>	6055	Use of Metaiodobenzylguanidine-123 Scintigraphy in the evaluation of the response to Renal Sympathetic Denervation in patients with treatment-resistant hypertension	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-03-01	Instituto Dante Pazzanese de Cardiologia	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-10h5gd44	<NULL>	treatment resistant hypertension; age between 18 and 75 years old	Secondary hypertension; advanced chronic renal failure (creatinine clearance &lt; 30 ml/min); abnormal renal vascular anatomy (diameter less than 3 mm; extent less than 20 mm; or stenosis greater than 30%); allergic reaction to the iodine contrast; pregnant women; unable to understand the study or sign the consent form; patients with decompensated heart failure; hemorrhagic diathesis; consumptive diseases; severe peripheral arterial obstructive disease; acute diseases such as coronary and cerebrovascular syndromes were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-83tdxm4	Impact of Parental Coaching on the development of early childhood children with warning signs for Autism Spectrum Disorder	Data analysis completed	Intervention	2023-05-11	<NULL>	<NULL>	6069	Effectiveness of parental coaching model on the development of social communication and behavior patterns of early childhood children at risk for Autism Spectrum Disorder: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-83tdxm4	<NULL>	Children with warning signs for Autism Spectrum Disorder with scores greater than 7 on the M-CHAT-R/F; both genders; age range from 16 to 30 months; parents/caregivers willing to participate in the study	Children with extreme prematurity and low birth weight; presence of motor, physical alteration and/or identification of genetic syndrome in the child	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-105p888f	Preventive correction of fibrinolysis with Epsilon Aminocaproic Acid detected by Thromboelastometry during Liver Transplant	Data analysis completed	Intervention	2023-05-12	<NULL>	<NULL>	6070	Prophylactic correction of fibrinolysis with Epsilon Aminocaproic Acid diagnosed by Thromboelastometry during Orthotopic liver transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	José Carlos Rodrigues Nascimento	José Carlos Rodrigues Nascimento	https://ensaiosclinicos.gov.br/rg/RBR-105p888f	<NULL>	Patients undergoing liver transplantation; both sexes; age from 18 years	Patients with contraindications to antifibrinolytic therapy; such as disseminated intravascular coagulation; bacteremia; portal thrombosis; Budd-Chiari syndrome; neoplasia; autoimmune hepatitis; acute or chronic renal failure; those who refused to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-33qh2sy	Bodybuilding and Auriculotherapy as auxiliary treatments during Hemodialysis in patients with Kidney Disease	Data analysis completed	Intervention	2023-05-15	<NULL>	<NULL>	6077	Resistance Physical Exercise and Auricular Acupuncture as treatment tools non-pharmacological in Chronic Renal patients undergoing Hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-33qh2sy	<NULL>	Included in the study were patients of both genders; aged 18 years or older; who were under medical follow-up due to a diagnosis of chronic kidney disease; on hemodialysis for at least 6 months;	Patients who did not agree to participate in the research; those who died or dropped out; as well as those who were already doing auricular acupuncture and physical exercise outside the research will be excluded; Patients who had less than 75% adherence to the total number of sessions;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-10gqsbsm	Comparison of the effects of two breathing aids, the high-flow nasal cannula and the venturi mask, on exercise tolerance in lung transplant candidates	Data analysis completed	Intervention	2023-05-24	<NULL>	<NULL>	6102	Comparison of the effects of high-flow nasal cannula and venturi mask on exercise tolerance in lung transplant candidates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-22	Hospital de Messejana Dr Carlos Alberto Studart Gomes	Hospital de Messejana Dr Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-10gqsbsm	<NULL>	Lung transplant candidates; both genders; older than 18 years; in initial evaluation for inclusion in a pulmonary rehabilitation program; with oxygen dependency or need for oxygen supplementation during the symptom-limited incremental load test performed before inclusion in the study	Candidates who did not comply with the protocol, because they were absent on the assessment day; candidates who did not present clinical conditions on the day of the test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-5fc7f77	Evaluation of the potential of Ozone to whiten teeth without sensitivity	Data analysis completed	Intervention	2023-05-25	<NULL>	<NULL>	6107	Evaluation of the Application of Ozonized Gas in the reduction of post-office bleaching sensitivity - Clinical, randomized and blinded study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5fc7f77	<NULL>	Patients of both sexes, aged between 18 and 35 years; Patients with the presence of all vital anterior teeth, never bleached or restored; Patient with periodontal health; Patients without a history of spontaneous dental pain; Patients who do not use toothpaste with desensitizing properties; Patients willing to return for future evaluations during the research period	Patients with missing anterior teeth, affected by carious lesions, with the presence of recession, with some type of restorative or prosthetic treatment or who use fixed orthodontic appliances; Patient with bruxism or visible enamel cracks; Patients with a history of periodontal disease or active periodontal disease; Patients with a history of dental hypersensitivity; Patients with tooth discoloration due to fluorosis or tetracycline; Patients who use many medications; Pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7rk26hj	Discussion of the evaluation of the treatment of Partial Rupture of the Supraspinatus Tendon with the Needling technique associated with Platelet Rich Plasma	Data analysis completed	Intervention	2023-05-29	<NULL>	<NULL>	6117	Evaluation of the treatment of Partial Rupture of the Supraspinatus Tendon with the Dry Needling technique associated with Platelet Rich Plasma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-30	Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP	Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-7rk26hj	<NULL>	Patients of both sexes, aged over 25 years, with partial rupture of the supraspinatus less than or equal to 1 cm in the longitudinal axis evaluated by ultrasound.	Patients who underwent any ultrasound-guided needling procedure in the affected tendon, use of infiltration with corticosteroids in the affected shoulder in the last 6 months, presence of another pathology of the shoulder to be treated (fracture or arthritis of rheumatic origin), cervical spine radiculopathy, pregnancy, neoplasm, severe liver disease or nephropathy, autoimmune, inflammatory or infectious diseases, acute or chronic, hypersensitivity to lidocaine, use of anti-inflammatory drugs or corticosteroids in any form before 6 weeks of application of platelet-rich plasma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-96n5x69	Analysis of osseointegration of implants with different macrogeometries: a randomized clinical trial	Data analysis completed	Intervention	2023-06-19	<NULL>	<NULL>	6158	Analysis of osseointegration of implants with a new macrogeometry: randomized clinical trial in split mouth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-07	pontifícia universidade católica do paraná	pontifícia universidade católica do paraná	https://ensaiosclinicos.gov.br/rg/RBR-96n5x69	<NULL>	partial edentulous patients in the posterior region of the mandible requiring one implant in each half-arch or two implants in each half-arch;minimum bone height of 11 mm and minimum bone thickness of 5 mm in the posterior region of the bilateral mandible evaluated by means of cone beam computed tomography; sufficient prosthetic space for subsequent prosthetic rehabilitation	the need for some type of bone reconstruction or advanced surgery to allow the installation of the implant; patients who did not accept to be part of the study; patients with uncontrolled diabetes, considering glycated hemoglobin above 7.5%; smokers more than 10 cigarettes a day; use of oral or injectable bisphosphonates; immunodeficient patients; patients who underwent radiotherapy in the head and neck region for a period of less than five years before the beginning of the research; patients with another systemic condition that contraindicated performing oral surgery at the time or who had conditions that could interfere with the osseointegration process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-85qq6jc	The effect of a new Pleural Drainage System in thoracic surgery	Data analysis completed	Intervention	2023-06-22	<NULL>	<NULL>	6171	Evaluation of the effectiveness of the Sinapi Pleural Drainage System in thoracic surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-02	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-85qq6jc	<NULL>	Both genders; aged between 18 and 90 years; undergoing some type of partial lung resection	Pneumonectmy; joint wall resection; empyema on the same side of the surgery; VEF1 ppo (forced expiratory volume in one second predicted for the postoperative period) less than 40%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3vymq2j	The practice of Virtual physical exercise to work on physical, cognitive and psychological conditions in the elderly	Data analysis completed	Intervention	2023-06-22	<NULL>	<NULL>	6172	Intervention by Virtual physical exercise in physical, cognitive and psychological capacities in the elderly	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-11	Faculdade de Ciências Medicas - UNICAMP	Faculdade de Ciências Medicas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-3vymq2j	<NULL>	Be aged 70 years or older;  both genders; practitioners of physical exercise; obtain a score higher than the 25-point cutoff point of the Mini Mental State Examination	The individual cannot have previous diagnoses of diseases or serious physical and mental deficits which prevent participation in the research stages	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-7mzjqv4	Aerobic exercise and mood states	Data analysis completed	Intervention	2023-06-29	<NULL>	<NULL>	6187	Effects of different intensities of physical exercise on the quinurenine pathway and mood states	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7mzjqv4	<NULL>	Male gender. Aged between 20 and 35 years. Have a training routine with a minimum frequency of 3x/week, for a minimum period of one year. Be considered physically active by the International Physical Activity Questionnaire - IPAQ. Not present any type of psychological or eating disorder. Not chronically on medication. Need to be considered in good health after cardiological evaluation. Cannot have undergone surgery in the last 6 months. Cannot have any physical, muscular and/or joint problems	Inability to comply with the entire experimental protocol for any reason. Non-attendance at the stipulated times between tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-8x8pf6d	3D digital analysis of dental arches before and after surgery in patients with unilateral and bilateral cleft lip and palate	Data analysis completed	Observational	2023-06-30	<NULL>	<NULL>	6192	Use of 3D Sterephotogrammetry for volumetric analysis and image superimposition of the dental arches before and after surgeries in patients with unilateral and bilateral cleft lip and palate	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8x8pf6d	<NULL>	Participants with non-syndromic unilateral cleft lip and palate; all surgical procedures were performed by a single plastic surgeon; male and female genders	Poor quality dental models	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-942kk6s	Effect of strengthening the inspiratory muscles in patients after cardiac surgery	Data analysis completed	Intervention	2023-07-04	<NULL>	<NULL>	6200	Inspiratory muscle training in the postoperative period of cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Medicina do ABC	Hospital do Coração do Cariri - HCC	https://ensaiosclinicos.gov.br/rg/RBR-942kk6s	<NULL>	Patients in the postoperative period of elective cardiac surgery via sternotomy and using cardiopulmonary bypass; left ventricular ejection fraction above 40%; body mass index lower than 30 kg/m2.	Patients who required additional surgery during the postoperative period; as well as those who had complications such as cardiorespiratory arrest;  prolonged sedation; mechanical ventilation time greater than twenty-four hours;  neurological complications; patients who could not understand or collaborate with the procedures were also excluded since the conducts applied in the  inspiratory muscle training are volitional.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-79h2ppx	Analysis of intestinal mucosa and fat nearby the intestine in patients with Crohn&apos;s disease	Data analysis completed	Observational	2023-07-05	<NULL>	<NULL>	6203	Transcriptional analysis of intestinal mucosa and mesenteric adipose tissue of patients with Crohn&apos;s disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-10-25	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-79h2ppx	<NULL>	Patients with endoscopic and histological diagnosis of ileocecal Crohn&apos;s disease undergoing surgical procedure. For the control group of distal ileum, patients who underwent colonoscopy for other reasons, whose examination comes without endoscopic changes. For the control group of mesenteric adipose tissue (intestinal fat), patients with non inflammatory diseases of the left colon undergoing surgery, with normal terminal ileum. All survey participants are over 18 years of age	The patients participating in the control groups without the use of medication. And Crohn&apos;s patients with disease locations other than the small intestine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-8ygjpqm	Evolution of patients who underwent surgery for cancer treatment in Brazil during the COVID-19 pandemic	Data analysis completed	Observational	2023-07-11	<NULL>	<NULL>	6226	Prognosis of surgical oncology patients during the COVID-19 pandemic in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-03-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital do Câncer de Barretos - Fundação Pio XII	https://ensaiosclinicos.gov.br/rg/RBR-8ygjpqm	<NULL>	All patients undergoing surgeries for cancer treatment performed between March and June 2019 and between March and June 2020, who underwent postoperative care in the intensive care unit; with a minimum age of 18 years; both genders	Advanced cancer with no prospective of treatment, severe hepatic failure (Child C); hospital stay less than 12 hours; patients who undergo reoperation before inclusion in the study; readmission to intensive care unit during the same hospital stay of study inclusion; previously included patients; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-37f4x5p	Results of Physical Exercise in women with Breast Cancer undergoing Chemotherapy	Data analysis completed	Intervention	2023-07-13	<NULL>	<NULL>	6235	Effect of Physical Exercise on Functionality and Tumor Size in women with Breast Cancer undergoing Neoadjuvant Chemotherapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-18	Universidade Federal de Minas Gerais	Instituto de Previdência dos Servidores do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-37f4x5p	<NULL>	women diagnosed with breast cancer; aged between 18 and 69 years old; undergoing neoadjuvant chemotherapy	women with breast cancer; undergoing neoadjuvant chemotherapy who present some comorbidity such as cardiac dysfunctions that contraindicate the practice of physical exercise or present some inability to answer the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-3bbwwjz	Clinical performance of two glass ionomer cements used as restorative materials in Atraumatic Restorative Treatment (dental restorations)	Data analysis completed	Intervention	2023-07-24	<NULL>	<NULL>	6264	Clinical evaluation of glass ionomer cements used in Atraumatic Restorative Treatment (ART)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3bbwwjz	<NULL>	Children and adolescents in good general health; aged between 10 and 15 years; both sexes; residents of the municipality of Sobral; present a collaborative behavior to carry out the clinical procedure; present at least one of the upper and/or lower permanent molars with cavitated dentin occlusal caries lesion accessible to manual instruments with a minimum opening of 0.9 mm; present the Informed Consent Term signed by the parents/guardians	Permanent molars with pulp exposure; fistula; abscess; pathological mobility; spontaneous pain; carious dentin lesion not accessible to hand instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-857nczs	Nursing intervention for reducing anxiety in individuals undergoing unscheduled cardiac catheterism	Data analysis completed	Intervention	2023-07-24	<NULL>	<NULL>	6265	Nursing intervention for reducing anxiety in individuals undergoing unscheduled cardiac catheterism: pilot study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-19	Escola de Enfermagem da Universidade de São Paulo	Instituto do Coração	https://ensaiosclinicos.gov.br/rg/RBR-857nczs	<NULL>	People with acute coronary syndrome awaiting unscheduled catheterization, diagnostic or therapeutic, were included. Unscheduled catheterization was understood in this study as a percutaneous procedure not scheduled on an outpatient basis and performed due to the diagnosis of ACS after the individual&apos;s admission to the emergency unit. Individuals aged 18 years or older; literate; hemodynamically stable with or without the use of vasoactive drugs; and who were performing cardiac catheterization for the first time or for more than a year were included. Individuals with a diagnosis of psychiatric disorder and use of mood modulators, prescribed or not, were not included.	Individuals with hearing loss that prevented them from listening to music within the established parameters, who presented hemodynamic instability during data collection, were excluded; those whose therapeutic plan was modified and did not undergo the procedure and those who were interrupted for any reason while offering the musical component of the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-8wqqmk8	Comparison of clinical simulation and deliberate practice in rapid cycles for clinical competence development: a randomized clinical trial	Data analysis completed	Intervention	2023-07-28	<NULL>	<NULL>	6281	Evaluation of clinical simulation and deliberate practice in rapid cycles for the development of clinical competence: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8wqqmk8	<NULL>	The student must be enrolled in the fourth year of nursing at the Federal University of São Paulo; have participated in the lecture dialogued in the remote modality on Nursing Assistance to the patient with Cerebral Vascular Accident in the Emergency Service lasting 40 minutes; both genders	Graduates not enrolled in the fourth year of nursing at the Federal University of São Paulo; those who do not participate in the lecture dialogued in the remote modality on Nursing care for patients with stroke in the Emergency Service lasting 40 minutes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-6brhz73	Effects of Transcranial Electrical Stimulation associated with Electrical Stimulation in the leg on gait recovery in individuals after chronic Stroke: a randomized controlled clinical trial	Data analysis completed	Intervention	2023-08-07	<NULL>	<NULL>	6313	Effects of Transcranial Direct Current Stimulation associated with Peripheral Electrical Stimulation on the functional recovery of individuals after chronic Stroke: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Federal do Ceará	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6brhz73	<NULL>	Volunteer of both sexes; single case of stroke for at least 6 months; ischemic or hemorrhagic brain injury; age above 18 years; presence of motor sequelae in one hemibody; ability to walk approximately 10 meters on the ground with or without a walking aid; minimum score of 24 points (for individuals with schooling) or 18 points (for individuals with no schooling) on ​​the mini-mental state exam	Epilepsy episodes; undiagnosed headache; intracranial metal implant; cardiac pacemaker; pregnancy (or suspected); depression; other clinical conditions of orthopedic, neurological or cardiac origin that do not allow participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-8xvwgf7	Evaluation of pain and the amount of medication used after root canal treatment in molars with and without enlargement of the final root area: a clinical study	Data analysis completed	Intervention	2023-08-08	<NULL>	<NULL>	6318	Evaluation of post-operative pain and analgesic use after Endodontic Treatment in molars with and without forminal enlargment: prospective randomized clinical test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-15	Fabiana Menezes Galdino de Aragao	Centro de Pesquisas Odontologicas São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-8xvwgf7	<NULL>	Healthy volunteers; both sexes; age above 18 years	Pregnancy; diabetics; immunosuppressed patients; under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-8fsspyy	Effects of Botulinum Toxin Type A in patients with chronic orofacial pain	Data analysis completed	Intervention	2020-12-15	<NULL>	<NULL>	6357	Comparison of the efficacy of Botulinum Toxin Type A in patients with refractory chronic orofacial pain according to different somatosensory profiles	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8fsspyy	<NULL>	Volunteers of both genders; aged between 20 and 50 years; with myofascial Temporomandiibular Disorders; in pain for more than three months; refractory to conventional therapies	Volunteers with facial and Temporomanbular Joint trauma; using full dentures or removable partial dentures; ongoing orthodontic treatment; blood dyscrasia patients; with presence of arthritis; arthrosis; diabetes; neurological pathologies; fibromyalgia; who received tetanus vaccine or botulinum toxin injections in the three months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3n7pzqt	Analysis of the Effectiveness of the Anti-motion Sickness Glasses for Reading in Vehicles	Data analysis completed	Intervention	2023-08-17	<NULL>	<NULL>	6358	Validation of Antikinetosis Sickness Glasses for Reading in Vehicles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-03	APEC - Sociedade Potiguar de Educação e Cultura S.A	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3n7pzqt	<NULL>	Being a student at the Universidade Potiguar; having signs or symptoms of motion sickness while reading in vehicles; not being under the use of antikinetosis medication; be at least 18 years old.	The exclusion criterion is not meeting all the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3jpnxqw	Use of Citicoline in Children with Attention Deficit Hyperactivity Disorder	Data analysis completed	Intervention	2023-08-21	<NULL>	<NULL>	6364	Use of Citicoline in Attention Deficit Hyperactivity Disorder - randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade do Vale do Taquari  - Univates	Universidade do Vale do Taquari  - Univates	https://ensaiosclinicos.gov.br/rg/RBR-3jpnxqw	<NULL>	Diagnosis of Attention Deficit Hyperactivity Disorder according to DSM-5 criteria, confirmed by the investigator&apos;s judgment. Age between 7 and 12 years old.  Both genders. Subjects using psychopharmacological treatment considered adequate by the investigator, in a stable dose for at least 4 weeks before inclusion, with no need to adjust the dose throughout the study	Other comorbidities that influence the neuropsychological assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-6xkzrfy	Effectiveness of tea made from Cissampelos sympodialis leaves in the treatment of anxiety and depression: a controlled clinical trial	Data analysis completed	Intervention	2023-08-22	<NULL>	<NULL>	6368	Infusion of the leaves of Cissampelos sympodialis Eichl. and auriculotherapy: modulation of anxiety and depressed mood	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-25	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-6xkzrfy	<NULL>	Adults aged at least 18 years old; physically and psychologically able to talk to the interviewers; intellectual and cognitive capacity to complete the questionnaires. They must attend the CRAS.	Pregnant women; nursing mothers; kidney disease patients; liver disease patients; use of psychotropic drugs; do not have the ability to understand and answer the questionnaires; sleeping during the intervention; refuse to receive the interventions; refuse to answer questions; refuse to sign the Term of Free and Clarified Consent (TCLE); Individuals whose external ear presents anatomical variations that make it difficult to locate the auricular points.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-78gvj3g	Early refeeding after cesarean section: assessing the return of gastrointestinal function	Data analysis completed	Intervention	2023-08-24	<NULL>	<NULL>	6385	Early refeeding after cesarean section in a private hospital in Maceió: impact on the health of the maternal-fetal binomial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-06	Faculdade de Medicina da Universidade Federal de Alagoas	Unimed Maceio Cooperativa de Trabalho Medico (Hospital UNIMED)	https://ensaiosclinicos.gov.br/rg/RBR-78gvj3g	<NULL>	Parturients undergoing cesarean section; aged between 18 and 45 years; who were submitted to spinal anesthesia, under aseptic technique, followed by median puncture in the vertebral space between the third and fourth lumbar vertebrae with a 27G Whitacre needle, flowing clear cerebrospinal fluid and intrathecal injection of heavy bupivacaine 12.5mg plus morphine 60mcg	Patients with twin pregnancies; those with comorbidities resulting from pregnancy; patients with any type of perioperative intercurrence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-8xh2j23	Association between delta anion gap/delta bicarbonate and patient outcome in surgical patients admitted to intensive care	Data analysis completed	Observational	2023-08-28	<NULL>	<NULL>	6393	Evaluation of the delta anion gap / delta bicarbonate correlation in the outcome in the ICU of patients undergoing major surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2012-09-03	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HC- FMUSP	Hospital do servidor Público Estadual de São Paulo - HSPE/IAMSPE	https://ensaiosclinicos.gov.br/rg/RBR-8xh2j23	<NULL>	Surgical patients (age ≥ 18 years) admitted to the ICU consecutively during the study period and at least one of the following criteria: severe cardiorespiratory disease (presence of coronary artery disease, aortic surgery, chronic obstructive pulmonary disease, or stroke); cancer surgery with extensive resection (esophagectomy, total gastrectomy, liver resection, pancreatectomy, cystectomy or total colectomy); surgical time greater than 6 hours; severe polytrauma; Massive intraoperative blood loss (hematocrit &lt; 20%); intraoperative circulatory shock (mean arterial pressure &lt; 60 mmHg) requiring vasopressors; previous nutritional disorder; body mass index &lt; 20; patients over 65 years of age with evidence of physiological limitation in at least one vital organ	"Patients who stayed less than 24 hours in the intensive therapy ; patients with low life expectancy (cancer with no prospect of treatment); patients with liver failure - (child B or C); patients with renal insufficiency (creatinine clearance &lt; 50mL/min or prior hemodialysis); diagnosis of previous diabetes or two blood glucose levels &gt; 126 mg/dL after
perioperative 8-hour fasting"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-9hdpq5	Efficacy of Acupuncture in improving pain, function and quality of life in patients with Masticatory Myofascial Pain	Data analysis completed	Intervention	2018-10-05	<NULL>	<NULL>	6395	Efficacy of Acupuncture in pain, Mandibular function and quality of life in patients with Myofascial Masticatory Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9hdpq5	<NULL>	Adults aged 18 to 60 years with a diagnosis of temporomandibular muscle dysfunction, masticatory myofascial pain, according to the Research Diagnostic Criteria for Temporomandibular Disorders; pain of intensity 4 or higher measured by visual analogue scale; pain for at least 3 months; possibility of attending appointments during the treatment and evaluation period	History of facial trauma; pregnancy; acuphobia; continuous use of nonsteroidal anti-inflammatory drugs, analgesics, antidepressants or muscle relaxants; intracranial, neurological and other major causes of headache disorders; other causes of orofacial pain; temporomandibular joint arthralgia; being submitted to another type of treatment for temporomandibular disorders; diagnosis of fibromyalgia; edentulism; use of complete denture; non-acceptance to voluntarily participate in the research or refusal to sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-437fmbz	Evaluation of the genital mucosa of a topical product under normal conditions	Data analysis completed	Intervention	2022-06-23	<NULL>	<NULL>	6409	Assessment of cutaneous and genital mucosa acceptability of a topical product under normal conditions of use	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2022-08-15	Allergisa  Pesquisa dermato-cosmética  ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-437fmbz	<NULL>	Healthy research participants; intact skin in the test region; agreement to adhere to the study procedures and requirements and to attend the institute on the day(s) and time(s) determined for the assessments; ability to consent to their participation in the study; age from 18 to 70 years; female survey participants	"Pregnancy or breastfeeding, having a menstrual period at the time of the study visits, skin pathology in the area of ​​application of the product, type 1 diabetes Mellitus, insulin-dependent diabetes, presence of complications due to diabetes (retinopathies, nephropathy, neuropathy); presence of diabetes-related dermatoses (plantar ulcer, necrobiosis lipoidica, granuloma annulare, opportunistic infections);
history of episodes of hypoglycemia, diabetic ketoacidosis and/or hyperosmolar coma, immune failure, Current use of the following topical or systemic medications: corticosteroids, immunosuppressants and antihistamines, skin diseases: vitiligo, psoriasis, atopic dermatitis, history of reaction to the category of product tested, other diseases or medications that may directly interfere with the study or put the health of the research participant at risk"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-10nwcpsx	The effect of Activated Carbon-Based Toothpastes: Randomized clinical study	Data analysis completed	Intervention	2021-05-31	<NULL>	<NULL>	6418	Efficacy of Activated Carbon-Based Whitening Dentifrices: Randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade do Norte do Paraná	Universidade do Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10nwcpsx	<NULL>	18 to 40 years old and in good general health; six upper teeth fully erupted; without oral disease or dental restorations; at least one upper tooth showing A3 or darker shade, as measured with Vita Easyshade Advance 4.0 (Vita Zahnfabrik, Bad Säckingen, Germany) (ordered by brightness).	Systemic diseases or disorders of the oral mucosa; pre-lightening treatments; current orthodontic treatment or with parafunctional habits; pregnancy or lactating; known allergies to the product&apos;s ingredients; smoke; alcohol abuse; gingival recession; with structural enamel defect or with a history of dentin hypersensitivity; with one of the six anterior teeth with caries or a non-carious cervical lesion; with one of the six anterior teeth with more than 1/6 of its buccal surface restored; with one of the six anterior teeth with a medium shade lighter than A2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-4s4kt2r	Non-Invasive Stimulation in individuals with Chronic Stress	Data analysis completed	Intervention	2023-09-14	<NULL>	<NULL>	6430	Effects of Transcranial Direct Current Electrical Stimulation on right and left dorsolateral prefrontal cortex or Noninvasive Vagus Nerve Stimulation in Chronically Stressed adults	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4s4kt2r	<NULL>	Individuals diagnosed with stress; Lipp Adult Stress Symptom Inventory (ISSL) score greater than 4; cognitive ability to read and interpret the purpose of the research and answer the assessment instruments; and acknowledgment and approval of the informed consent form; male or female volunteers aged between 20 and 50 years	Smokers; with a history of dizziness or seizure; pregnancy; signs of severity and/or indications for hospitalization or psychotherapy; use of anxiolytics; use of antidepressants; adverse effects detected in the group treated with tDCS and taVNS, including itching, tingling, headache, burning sensation and discomfort; diagnosis of depression; anxiety diagnosis; mood disorder bipolar with depressive, manic or hypomanic symptoms in the last year; schizophrenia or other psychotic disorders; autism; dependency of substances; diagnosis of epilepsy or use of anticonvulsants; contraindications for TDCS (metallic implants, tumor, brain surgeries previous, important cranioencephalic anatomical alteration); contraindications for non-invasive vagus nerve stimulation (cochlear implant, ear plastic surgery, ear malformation); starting and/or changing the dose of psychopharmaceuticals in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-10r8cr8y	Relationship between baseline dental pulp response to stimulations and skin pressure sensitivity	Data analysis completed	Observational	2023-09-14	<NULL>	<NULL>	6432	Relationship between baseline pulpal response to electrical stimulation and skin pressure sensitivity	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-09-12	Faculdade de Odontologia da Universidade Estadual de Campinas	Faculdade de Odontologia da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10r8cr8y	<NULL>	aged between 18 and 35 years, classified as healthy through anamnesis, caries-free central incisors and upper canines and extensive restorations, trauma or endodontic treatment and responsive to electrical stimulation (pulp tester)	pregnant women, smokers, people undergoing tooth whitening in the past three months, evidence of organic dysfunction or clinically significant deviation from normal, history of psychiatric illness that could compromise the ability to provide written consent, history of drug addiction or drug abuse alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-2g9k29z	Non-Invasive Brain Stimulation performed during a donation task can modulate parts of the brain and emotional experience	Data analysis completed	Intervention	2023-09-20	<NULL>	<NULL>	6453	Exploring the neural correlates of charitable giving - a Non-Invasive Brain Stimulation Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Instituto D&apos;Or de Pesquisa e Ensino	FAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2g9k29z	<NULL>	Healthy volunteers; both genders; nonsmokers; age between 18 and 50 years; undergraduate students or holders of a college degree	Personal history of epilepsy; cardiac pacemaker; previous intracranial surgery; pregnancy; regular psychotropics intake; inability to give informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-108zwbzy	Use of Acupuncture in the health center of the Federal University of Ouro Preto/basic health unit Bauxita-Ouro Preto-MG like model for the treatment: evaluation of pain and inflammation in temporomandibular disorders in human	Data analysis completed	Intervention	2023-09-26	<NULL>	<NULL>	6463	Implementation of Acupuncture in the health center of the Federal University of Ouro Preto/basic health unit Bauxita-Ouro Preto-MG with proposal of guidelines for the treatment: subjective, biochemical and physical evaluation of pain and inflammation in temporomandibular disorders in human model	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-108zwbzy	<NULL>	female; age range 20 to 59 years; orofacial pain; being more than 3 months without receiving treatment with acupuncture or for temporomandibular dysfunction	pregnant women; active cancer; fear of needles; undergoing acupuncture treatment; taking pain medication; pain from trauma; wearing an orthodontic appliance; wearing an occlusal plate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-8yq5b8h	Treatment of dentin hypersensitivity with 5% sodium fluoride varnish, low level laser therapy and associated application: randomized split-mouth clinical study	Data analysis completed	Intervention	2023-09-26	<NULL>	<NULL>	6464	Treatment of dentin hypersensitivity with 5% sodium fluoride varnish, low level laser therapy and associated application: a clinical, controlled, randomized, split-mouth study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-10	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8yq5b8h	<NULL>	Healthy volunteers; male or female aged between 20 and 65 years; with healthy periodontium; no periodontitis or gingivitis; presenting teeth without the presence of caries, cracks, fractures or extensive restorations; presenting teeth without premature contact; volunteers who have understood the study design; volunteers who have at least four sensitive teeth in their mouths, one in each oral quadrant; volunteers who have signed and agreed to the Informed Consent Form	Pregnant or breastfeeding women; subjects registered in another clinical trial; individuals who underwent professional treatment for hypersensitivity, or who used desensitizing products in the 3 months preceding the research period; history of maxillofacial cancer in the last 5 years; need for systemic treatment due to infection; patients who make chronic use of anti-inflammatory drugs, analgesics or psychotropic drugs; individuals who have allergies or who have some idiosyncratic response to any component of the product used in the research; patients who present parafunctional habits, eating disorders, gastric or emotional illness that is predisposed to dentin sensitivity; advanced medical or psychological illness; alcohol consumption or drug intoxication; hemorrhagic disease; systemic condition that is an etiological or predisposing factor for dentin sensitivity; diet with excessive exposure to acidic foods; individuals who underwent periodontal surgery or orthodontic treatment in the preceding 3 months; dental or periodontal pathologies, or defects that cause pain, such as caries, “brackets”, and extensive fillings; teeth that serve as &quot;abutments&quot; or support for fixed or removable dentures, or that have crowns; teeth with restorations that extend to the test area (cervical); teeth with irreversible pulp inflammation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-10tgxp8n	The influence of elastic bandage on knee pain and function in women with Patellofemoral pain syndrome	Data analysis completed	Intervention	2023-09-26	<NULL>	<NULL>	6465	Analysis of the influence of elastic bandage on quadriceps muscle performance in women with Patellofemoral pain syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10tgxp8n	<NULL>	Be between 18 and 35 years old, be female. Present pain in the anterior region of the knee for at least three months and refer pain in three of the functional activities such as squatting, jumping, climbing and descending stairs, kneeling, running or sitting for a long time. (McConnel, 1996), pain on palpation in the medial or lateral region of the patella, pain level on the Visual Analog Scale is greater than or equal to three, as suggested by Mostamand et al. (2011), BMI less than 29.9kg/m²	Physical or mental disability, use of assistive walking devices, history of orthopedic surgery or use of orthosis/prosthesis, allergy to elastic bandage, history of severe knee injury (ligaments, menisci or tendon tears), neurological, rheumatic or cardiovascular diseases that make it impossible to carry out the proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-245rh7	Neuromodulation and its therapeutic potentiality in different populations	Data analysis completed	Intervention	2019-09-12	<NULL>	<NULL>	6486	Transcranial Direct Current Stimulation (TDCS) and its therapeutic potentiality in different populations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-245rh7	<NULL>	Man or woman aged 18 to 65 years; be in chronic phase of chikungunya fever (least 3 month of the initial infection) and show laboratory tests or clinical diagnostic confirmation of chikungunya virus; pain related with more than 4 in a numeric rating scale; to have physical capacity to do physical evaluation and be capable of consenting to treatment and understanding study explanations and questionnaires; having provided informed consent	Electrical implants in the body; a history of epilepsy; people who are clinically contraindicated to receive tDCS such as having metal embedded in their scalp or brain; psychiatric illness, and history of drug abuse; pregnant women; signs of severity and/or indication of hospitalization; presence of previous rheumatic disease including gout, rheumatoid arthritis, fibromyalgia, lupus and others chronic pain syndromes with diagnosis prior to chikungunya	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-3vmy6sq	Effectiveness of Routine Outcome Monitoring in Psychotherapy in the period of the COVID-19 pandemic	Data analysis completed	Intervention	2023-10-06	<NULL>	<NULL>	6487	Evaluation of the effectiveness of Psychotherapy in the period of the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	APHETO - Laboratório de Psicopatologia e Clínica Humanista Fenomenológica	Serviço de Psicologia Aplicada (SPA)	https://ensaiosclinicos.gov.br/rg/RBR-3vmy6sq	<NULL>	Persons over 18 years of age; Be registered with the Unified Health System (SUS); Be regulated in the SPA-NAMI system (study site); Present emotional distress in the COVID-19 pandemic period, through self-report in screening; Have availability for weekly psychotherapeutic care, with an average duration of 50 minutes, for six months remote or in person; Possess cognitive ability that allows the understanding and completion of the OQ®-45.2 and OQ®-ASC research instruments	Participants who were experiencing a severe emotional crisis related to a moderate or severe psychiatric disorder, which made systematic psychotherapeutic follow-up impossible; Patients who were already undergoing psychotherapeutic follow-up with another professional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-48wwhsw	Evaluation of the effect of venous anesthesia during Gallbladder Removal Surgery on pain intensity and acute inflammatory response	Data analysis completed	Intervention	2023-10-10	<NULL>	<NULL>	6496	Evaluation of the effect of intraoperative venous Lidocaine on pain intensity and plasma interleukin-6 (IL-6) concentration in patients undergoing Laparoscopic Cholecystectomy	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-12-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-48wwhsw	<NULL>	Patients over 18 years of age, ASA I-III, of both genders, who underwent videolaparoscopic cholecystectomies were included in the study.	Patients who had cardiac arrhythmias, dilated cardiomyopathy, cardiac conduction disorders, electrolyte disorders, acid-base disorders, hypersensitivity to lidocaine, psychiatric, liver, respiratory or oncological diseases, who had been receiving any type of analgesic in the previous week were excluded from the study, surgery and those who received blood products during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-103yr8h9	Acute effect of Electrical Stimulation applied to the scalp on pelvic floor muscle contraction function in healthy women	Data analysis completed	Intervention	2023-10-12	<NULL>	<NULL>	6502	Acute effect of Transcranial Direct Current Stimulation (electrical stimulation applied to the scalp) on the function of contraction (as if holding urine and then relaxing) of pelvic floor muscles (muscles that control urine and stool) in healthy women	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-09-05	Angela Cristina Ledur	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-103yr8h9	<NULL>	Healthy women; Nulliparous;18 and 45 years; sexually active in the last four weeks.	Participants who present any type of symptom or conditions that are linked to any change in the bladder, bowel and vagina/pelvis evaluated by the sample characterization form and applied questionnaire; chronic degenerative diseases; neurological disease; psychiatric disease; women who have undergone previous pelvic floor reeducation programs and/or pelvic floor surgeries for treatment of urinary infection or other conditions in the pelvic region; pregnant women; women with pacemaker or present any contraindications to the use of transcranial direct current stimulation; or present anesthesia or hyperesthesia at the transcranial direct current stimulation application site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-4292nhn	Telerehabilitation in the postoperative period of Breast Cancer	Data analysis completed	Intervention	2023-10-18	<NULL>	<NULL>	6519	Effects of Telerehabilitation in patients submitted to surgical treatment of Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Hospital Universitário João de Barros Barreto	Hospital Universitário João de Barros Barreto	https://ensaiosclinicos.gov.br/rg/RBR-4292nhn	<NULL>	"Patients with age above 18 years. be male and female. having a diagnosis of breast cancer in
all of its clinical stages. having undergone surgery for the treatment of breast cancer
mom. be in a period of 15 days after surgery. show ability to preserved verbal communication. being accompanied at the João de Barros Barretos University Hospital"	Having an associated disease that may generate some other type of functional impairment. have high-intensity pain. not have access to a cell phone. do not accept to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-5g75r5s	Encouraging healthy eating among elementary school pupils by making changes in the school environment	Data analysis completed	Intervention	2023-11-03	<NULL>	<NULL>	6562	Promoting healthy eating in elementary school children using Architecture of Choices and Cooking Workshop strategies	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5g75r5s	<NULL>	Literate students; age between 7 and 12 years; students with signature of the Informed Consent Form by the guardians; signature of the Consent Form by the student.	Non-literate students; students under the age of 7; students with specific educational needs that result in difficulty or hindrance to the development of interpersonal relationships and/or academic development (for example: autistic spectrum disorder); students whose guardians have not signed the Informed Consent Form; students who have not signed the Consent Form; students with specific physical needs that make anthropometric evaluation difficult or impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-3cb6qtz	Acute Cajuína (Anacardium occidentale L.) intake does not improve Leukocyte count, Lipid peroxidation, and Physical performance in Runners: a double-blind, crossover, randomized, placebo-controlled clinical trial.	Data analysis completed	Intervention	2023-11-17	<NULL>	<NULL>	6586	Effects of Cajuína on biochemical, physiological, and cognitive markers in Runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-12	Universidade Estadual Vale do Acaraú	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3cb6qtz	<NULL>	absence of any health-related conditions; no use of nutritional supplements for at least three months, including the duration of the study; non-smokers or drinkers; participation in national and state competitions in recent months; ability to complete a 10-km run in less than 60 minutes	consumers of cashew juice, cajuína, or any other product containing polyphenols such as grape, red wine, and cocoa; myotendinous injury during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-2ww2ts8	Effects of Electrical Stimulation in the head or ear region in adults with chronic stress	Data analysis completed	Intervention	2023-11-22	<NULL>	<NULL>	6602	Effects of Transcranial Direct Current Stimulation on the right and left dorsolateral prefrontal cortex or Non-Invasive Vagus Nerve Stimulation in adults with Chronic Stress	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2ww2ts8	<NULL>	Inclusion criteria consider individuals diagnosed with stress; Lipp adult stress symptom inventory score above 4; cognitive ability to read and interpret the purpose of the research and to respond to assessment instruments; and knowledge and consent of the free and informed consent form; Male or female volunteers aged between 20 and 50 will be recruited	Os critérios de exclusão são indivíduos fumantes; com história de tontura ou convulsão; gravidez; sinais de gravidade e/ou indicações de internação ou psicoterapia; uso de ansiolíticos; uso de antidepressivos; efeitos adversos detectados no grupo tratado com tDCS e taVNS, entre os quais coceira, formigamento, dor de cabeça, ardor, sensação e desconforto; diagnóstico de depressão; diagnóstico de ansiedade; transtorno de humor bipolar com sintomas depressivos, maníacos ou hipomaníacos no último ano; esquizofrenia ou outros transtornos psicóticos; autismo; dependência de substâncias; diagnóstico de epilepsia ou uso de anticonvulsivantes; contraindicações para a TDCS (implantes metálicos, tumor, cirurgias cerebral prévia, alteração anatômica cranioencefálica importante); contraindicações para a estimulação não invasiva do nervo vago (implante coclear, cirurgia plástica na orelha, má formação na orelha); iniciar e/ou intensidade de estimulação (mA), a largura de pulso (duração do pulso elétrico, ms), a frequência de pulso (Hz), e a relação on/off do ciclo de estímulo (medido em segundos ou minutos) são ajustados para otimizar a eficácia e tolerabilidade, porém ainda são um assunto a ser debatido.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-462vwq5	An oral inflammatory disease and the relationship in the development of nosocomial pneumonia	Data analysis completed	Observational	2023-11-28	<NULL>	<NULL>	6615	Periodontitis in the development of ventilator-associated Pneumonia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-01	Centro de Ciências Biológicas e da Saúde CCBS - UNIOESTE	Centro de Ciências Biológicas e da Saúde CCBS - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-462vwq5	<NULL>	Individuals over 18 years of age; both genders; admitted to the General ICU of Hospital Universitário do Oeste do Paraná; patients on mechanical ventilation for the first 72 hours; with at least six teeth	Patients with severe maxillofacial trauma that made examination difficult; using complete dentures (upper and lower); pregnant women; immunosuppressed; using any anti-inflammatory and antibiotic for more than three days; serious medical or surgical complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-10gjvcyt	May geometric modifications of implants influence implant repair in smokers?	Data analysis completed	Intervention	2023-12-06	<NULL>	<NULL>	6633	Clinical study of the influence of different macrogeometries and surface treatments of dental implants inserted in smoking patients. Clinical aspects and immunological	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-15	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-10gjvcyt	<NULL>	Smokers who smoke more than 10 cigarettes/day; aged between 18 and 65 years; both genders; with the presence of at least 20 teeth in the oral cavity; bilateral and homologous unitary prosthetic space	Presence of systemic diseases that could interfere with bone regeneration, such as diabetes, arthritis, hypothyroidism, hyperparathyroidism, and osteoporosis; pregnancy or breastfeeding; use of medications that counter-indicated the performance of surgical procedures or that could alter bone regeneration around implants (e.g., anti-inflammatory and bisphosphonate drugs); absence of keratinized tissue at the implant insertion sites (may interfere with hygiene around the implants); need for bone or tissue grafts	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-3rnskcj	Deferoxamine to treat Iron Overload in patients on Dialysis: effect on bone, myocardial and liver	Data analysis completed	Intervention	2023-12-11	<NULL>	<NULL>	6646	Use of Deferoxamine in the treatment of Iron Overload in patients on Dialysis: impact on bone remodeling, myocardial function and liver storage	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Hospital das Clinicas da Universidade de Sao Paulo	Hospital das Clinicas da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3rnskcj	<NULL>	Adult patient on maintenance hemodialysisl; serum ferritin higher than 1000 ng/ml	Active smoking; Active use of alcohol; Previous use of desferoxamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-4ttmrg6	Children&apos;s activities and social participation	Data analysis completed	Observational	2023-12-11	<NULL>	<NULL>	6650	Activities and social participation of children with atypical Motor Development	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-22	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4ttmrg6	<NULL>	Adults with 18 years of age or older; both genders; legal guardians of children aged up to 11 years and 11 months with motor disability in Physio-therapeutic care at the School Clinic on the Realengo, campus of the Federal Institute of Education, Science and Technology of Rio de Janeiro	Guardians of children with a health condition associated with the Nervous System without motor limitations;  guardians of children with other health conditions; guardians under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-107wh2sv	Mindfulness to improve the Quality of Life of individuals with Chronic Diseases accompanied by the SUS in the State of São Paulo- Brazil	Data analysis completed	Intervention	2023-12-12	<NULL>	<NULL>	6651	Mindfulness to improve the Quality of Life of individuals with Chronic Conditions Primary Health Care in the State of São Paulo- Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de São Paulo	Universidade Federal de Pernambuco- Acadêmico de Vitória	https://ensaiosclinicos.gov.br/rg/RBR-107wh2sv	<NULL>	Volunteers diagnosed with cardiovascular disease - systemic arterial hypertension; Diabetes Mellitus; chronic respiratory diseases; chronic kidney disease; chronic liver diseases; bone and joint diseases; psychiatric illnesses, adults and elderly people, of both sexes, with a minimum age of 18 and a maximum of 70 years	Volunteers who are unable to read and/or write and/or understand the assessment questionnaires; moderate to severe cognitive impairment; individuals with decompensation or exacerbation of other Chronic Non-Communicable Diseases; pregnant women; individuals who have some serious psychopathology (for example, psychotic disorder, deep depression or substance use disorder) and/or who practice meditation at the time of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5g4g9bq	Effects of walking training in individuals with stroke	Data analysis completed	Intervention	2023-12-12	<NULL>	<NULL>	6652	Effect of total walking volume on functional mobility, gait, and cardiovascular risk in individuals with chronic stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Associação das Pioneiras Sociais	Associação das Pioneiras Sociais	https://ensaiosclinicos.gov.br/rg/RBR-5g4g9bq	<NULL>	Medical diagnosis of a stroke that occurred at least 6 months ago and no participation in physical training or rehabilitation programs during the study period.	Inability to walk at least 10 meters without assistance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-6874vff	Effects of High Intensity Training in patients who underwent Angioplasty	Data analysis completed	Intervention	2023-12-13	<NULL>	<NULL>	6655	Effects of High Intensity Interval Training in patients undergoing Primary Angioplasty	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Hospital Ilha do Leite (Hapvida)	Instituto de Cardiologia o Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6874vff	<NULL>	The main inclusion criteria to participate in the present study are participants between 40 and 65 years old; who underwent myocardial revascularization through angioplasty with occlusion ≥ 50%; must have preserved ejection function with an ejection fraction ≥ 40%; no signs of moderate or severe myocardial ischemia detected by perfusion scintigraphy; do not present with angina; do not present ischemia caused by physical exercise; not participate in any type of systematic physical activity; and be classified among those irregularly active	Those patients who present the following symptoms during the study will be excluded from the study. unstable angina; decompensated systemic arterial hypertension with SBP≥180 mmHg or DBP≥110 mmHg; drop in orthostatic pressure of 20 mm Hg with symptoms, significant aortic stenosis with aortic valve area of 1.0 cm2; uncontrolled ventricular or atrial arrhythmia; sinus tachycardia ≥120 bpm; third-degree atrioventricular block without a pacemaker; active pericarditis or myocarditis; recent embolism; acute thrombophlebitis; uncontrolled diabetes mellitus; have orthopedic limitations or any physical or mental limitation that prevents the performance of physical exercises; not attending at least 85% of physical training sessions or missing an entire week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-7h5qzf	Cerebral Stimulation with Electric Current in children and adolescents with Attention-Deficit Hyperactivity Disorder	Data analysis completed	Intervention	2018-09-13	<NULL>	<NULL>	6695	Transcranial Direct Current Stimulation in children and adolescents with Attention Deficit Hyperactivity Disorder	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-14	Faculdade de Medicina da Bahia	Faculdade de Medicina da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7h5qzf	<NULL>	right-handed; literate and inserted in regular schools; residing in Salvador or metropolitan region; without pharmacological treatment during the stimulation period; electroencephalogram without epileptogenic activity; consent of those responsible	sensory deficit; other neuropsychiatric disorders; epileptogenic discharges on the electroencephalogram	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-106bhfwy	Structured Respiratory Physiotherapy Protocol for Atelectasis in Pediatrics	Data analysis completed	Intervention	2024-01-02	<NULL>	<NULL>	6698	Structured Respiratory Physiotherapy protocol for resolution of Atelectasis in pediatric intensive care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-106bhfwy	<NULL>	Infants with 28 days to 24 months of age; both genders; on invasive mechanical ventilation for a period greater than or equal to 12 hours through an orotracheal cannula; diagnosed with Atelectasis by a pediatric intensive care physician through clinical and imaging examination (chest x-ray and lung ultrasound); whose legal guardians have authorized the child&apos;s participation in the study through the Free and Informed Consent Form	Patients with bilateral atelectasis; any type of air leak syndrome (such as: subcutaneous emphysema, pneumothorax, pneumatocele, pneumomediastinum); pulmonary hemorrhage; diseases that cause bone fragility (costal osteoporosis and osteomyelitis); chest and/or lung bruises; subcutaneous pacemaker; treatment with anticoagulants for more than 72 continuous hours; hemodynamic instability; thrombocytopenia (&lt;50,000 platelets); using a chest tube; with underlying neuromuscular or cardiac diseases and spinal deformities (kyphoscoliosis)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4995qng	Breathing Exercises in Healthy Children	Data analysis completed	Intervention	2024-01-09	<NULL>	<NULL>	6713	Expiratory Muscle Training in Healthy Children: Randomized Clinical Trial	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2022-08-12	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4995qng	<NULL>	Healthy subjects, aged between 3 and 12 years old, who do not have comorbidities, will be included in the study.	Subjects with any type of comorbidity and who are younger than 2 years and 11 months or older than 12 years and one month will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-7zz3b6p	Qualitative somatosensory clinical evaluation of recipient and donor sites of subepithelial connective tissue Grafts	Data analysis completed	Intervention	2024-01-12	<NULL>	<NULL>	6723	Somatosensory profile in recipient areas of connective tissue Graft and donor palate: retrospective qualitative sensory evaluation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zz3b6p	<NULL>	Patients of both genders; age between 18 - 70 years; normal and healthy palatal area; multiple gingival recessions (RT1) with at least one gingival recession ≥ 2 mm, including canines and premolars; systemically healthy patients with no contraindication to periodontal surgical procedures	Patients with prostheses with palatal coverage; palatal areas previously submitted to graft removal; teeth Mobility; smokers; pregnant and lactating women; history of periodontal disease or recurrent abscess formation; previously root coverage surgical procedures; use of medications (anticonvulsants, antihypertensives, contraceptives, or immunosuppressants) or drugs that influence wound healing; and a low level of oral hygiene (plaque index and bleeding index &gt;20%)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8462fhs	Dry Needling and temporomandibular dysfunction	Data analysis completed	Intervention	2024-01-14	<NULL>	<NULL>	6726	Evaluation of the effects of Dry Needling and Manual Therapy on pain in patients with Temporomandibular Disorder and its relationship with fear of Covid-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-04	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-8462fhs	<NULL>	Adults between 18 and 40 years old; both genders; diagnosed with Temporomandibular Disorders (TMD)	People under 18 and over 40; people undergoing orofacial treatment; people using psychotropic medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-4z7bc6	Contraceptive implant in adolescent postpartum	Data analysis completed	Intervention	2018-11-19	<NULL>	<NULL>	6735	Subdermal implant in adolescent postpartum: non-randomized clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-25	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4z7bc6	<NULL>	Adolescent postpartum until 19 years	Adolescent postpartum who do not wish to use any contraceptive method; who present absolute contraindication to the use of the contraceptive method chosen according to WHO or who are not able to attend childbirth review appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-6gs4bdh	Clinical study of the use of electrical stimulation on leg circulation and coagulation	Data analysis completed	Intervention	2024-01-29	<NULL>	<NULL>	6754	Study of the application of neuromuscular electrical stimulation on lower limb hemodynamics and systemic fibrinolytic activity	<NULL>	2-3, single-arm-study, single-blind	2-3	<NULL>	<NULL>	<NULL>	2019-11-06	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6gs4bdh	<NULL>	Being between 18 and 40 years old. Both genders. Sign the Free and Informed Consent Form.  Have a Body Mass Index (BMI) between 18 and 34 kg/m2	Use of illicit drugs in the last 12 months. Use of the following medications in the last 24 hours: medicines for headache with vascular effect, such as sumatriptan, ergot derivatives, isomeptene, etc, analgesics such as dipyrone and paracetamol, non-steroidal anti-inflammatory drugs such as ibuprofen, naproxen, diclofenac, etc.  Consumption of foods in the last 24 hours with a known effect on vascular reactivity, according to the list: coffee, folic acid, vitamin C, high doses of fish oil, vitamin supplements, fruits and vegetables in large quantities such as cranberries (also known as cranberries) and grapefruit (also known as grapefruit), beets and black currants, wine, tea, cocoa and derivatives, chocolate and hazelnuts, natural grape and orange juice, cheese, probiotics (foods with this effect), capsaicin, like pepper, energy drinks, beer. Any significant illness within the last 4 weeks of exposure. Pregnancy or lactation. Use of hormonal contraceptive method, including IUD etc., in the last 3 months. Active smoker or ex-smoker in the last 12 months. History of peripheral arterial obstructive disease. Ankle-brachial index less than 0.9, defined in anamnesis and physical examination. History of chronic venous insufficiency in the lower limbs. Ulcer on lower limbs. History of venous thromboembolism. History of fracture or presence of metallic implants in lower limbs. Have an infection at the electrode implantation site. Have participated in a drug or medical device study up to 4 weeks previously. Use of any neuro-modulating device. Surgery 3 months before the study (such as abdominal, gynecological, etc.). Trauma to the lower limbs that may prevent correct electrical stimulation of the common peroneal nerve. Use of a pacemaker or implantable cardioverter-defibrillator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-3n49nsj	Use of self-care supportedcin the management of diabetes mellitus in primary attention	Data analysis completed	Intervention	2024-01-30	<NULL>	<NULL>	6756	Self-care supported in the management of Diabetes Mellitus in primary care: intervention and assessment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3n49nsj	<NULL>	Be registered in the Family Health Units (USF) included in the study with a diagnosis of Type 2 Diabetes Mellitus; of both sexes; older than 18 years	Have a health problem that makes verbal communication difficult/impossible and/or traveling to the Family Health Units; not have telephone contact; change of coverage area of ​​the Family Health Units during data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7fvcjkz	Comparison between two treatments for Burning Mouth	Data analysis completed	Intervention	2022-03-30	<NULL>	<NULL>	6794	Comparative analysis of Burning Mouth Syndrome Treatment using Low Power Laser (LTTP) and Transcutaneous Electrical Nerve Stimulation System: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Departamento de Odontologia - Universidade Federal do Rio grande do Norte	Departamento de Odontologia - Universidade Federal do Rio grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7fvcjkz	<NULL>	Individuals of both sexes, over 18 years of age; subjects who had recurrent intraoral or dysesthetic burning sensation daily for more than 2 hours a day for more than 3 months without clinically evident causal lesions; individuals who presented a sensation of pain, burning or burning in the oral mucosa and who presented some local or systemic factor that justified such symptoms; individuals who were physically and emotionally able to participate in the study tests	Subjects who did not complete the study treatment protocol; individuals who presented clinical alterations in the oral mucosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-5q5z486	Knowledge, attitudes and practices of primary care professionals on sexual behavior and sexually transmitted infections in the elderly: a quasi-experimental study	Data analysis completed	Intervention	2024-02-23	<NULL>	<NULL>	6800	Knowledge, attitudes and practices of primary health care professionals about sexuality and sexually transmitted infections in the elderly: a quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade do Estado de Mato Grosso	Universidade do Estado de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-5q5z486	<NULL>	Volunteer Nurses; both sexes; unlimited minimum age; working in the municipality&apos;s Primary Care	Nurses on vacation; nurses on leave;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-9q7kvg	Osteopathic Manipulative Treatment in pregnant women	Data analysis completed	Intervention	2020-08-26	<NULL>	<NULL>	6811	Effects of Osteopathic Manipulative Treatment on the hemodynamics of pregnant women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Instituto Fernandes Figueira- IFF/Fiocruz	Instituto Fernandes Figueira- IFF/Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-9q7kvg	<NULL>	Normotensive and hypertensive pregnant women in the third trimester; over 18 years old; accepted at IFF/Fiocruz to carry out prenatal care in the outpatient clinic and in the pregnancy ward between July 2021 and September 2022	Pregnant women with bleeding; with clear signs of premature birth (contraction, dilation); with twin pregnancy; with fetal malformation; signs of eclampsia (based on blood and urine tests and BP measurement); and HELLP syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-7m7ct53	Influence of spirituality on blood pressure control	Data analysis completed	Intervention	2024-02-28	<NULL>	<NULL>	6816	Influence of spiritual well-being training on blood pressure control	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-27	Liga de Hipertensão Arterial da Universidade Federal de Goiás	Liga de Hipertensão Arterial da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7m7ct53	<NULL>	Hypertensive adults (stage 1 or 2) with low and moderate cardiovascular risk, on stable use of antihypertensive medication for more than thirty days, evaluated by pressure measurements of the last visit.	Stage 3 patient hypertensive	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-483ndsd	Effectiveness of immersive Virtual Reality on pain perception in children associated with vaccination: randomized pilot study	Data analysis completed	Intervention	2024-03-05	<NULL>	<NULL>	6829	Effect of Virtual Reality on children&apos;s pain perception during vaccination: pilot study of a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-483ndsd	<NULL>	Children between four and six years, 11 months and 29 days; any ethnicity; both sexes; accompanied by parents or legal guardian; received at least one of the five vaccines recommended for the age group; presented cognitive and emotional conditions that enabled the application of the data collection instrument	Child with visual impairment or significant reduction in visual acuity; epilepsy/seizure; pre-existing migraines; changes in sensitivity (decrease or increase) that generated discomfort during the use of virtual reality glasses (labyrinthitis); children with psychiatric illnesses; mood changes diagnosed in an acute state (anxiety and phobias); children with infections; burns or injuries to the face or head that interfered with putting on the immersive virtual reality glasses; strabismus; change in bone shape that made it difficult to adapt virtual reality glasses; having undergone an invasive procedure on the same day as vaccination, withdrawal of participation by the child or parents/legal guardian; presence of nausea; vomiting or other discomfort during the intervention with the immersive virtual reality glasses that did not allow the continued use of the virtual reality glasses; children who used oral, intramuscular or topical (at the site of the intramuscular procedure) analgesics (in less than 12 hours); wished not to use the immersive virtual reality glasses during the intramuscular vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-10sxrcrs	The use of needles or tuning forks to reduce stress in nursing professionals	Data analysis completed	Intervention	2021-10-15	<NULL>	<NULL>	6836	Acupuncture and acutone for stress reduction in nursing professionals: pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10sxrcrs	<NULL>	Nursing professionals of both genders, whose scores on the Perceived Stress Scale (≥ 25); who are not using other integrative or complementary health practices; and who are not in psychotherapy or psychiatric treatment	Participants who are not comfortable with needle sticks or tuning forks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-9v9gx9s	Effect of using Toothpastes with Desensitizers on reducing Tooth Sensitivity and Quality of Life in adults with previous sensitivity after dental bleaching	Data analysis completed	Intervention	2024-03-12	<NULL>	<NULL>	6851	Effect of using Toothpastes with Desensitizers on reducing Tooth Sensitivity and Quality of Life in adults with previous sensitivity after in-office dental bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9v9gx9s	<NULL>	Individuals dissatisfied with the color of their teeth and with good oral health;  anterosuperior teeth with vitality, free of cavities and restorations on the vestibular surface; upper central incisors with coloration equal to or darker than A2, according to the Vita Classical color scale; stimulated or provoked dentin sensitivity in any superior superior premolar, canine and incisive	Severe intrinsic stains on the teeth (such as tetracycline or fluorosis); active periodontal disease;  use of any anti-inflammatory, analgesic and antioxidant action drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-82rpdv9	Effects of food supplementation with vegetable oils containing Medium Chain Triglycerides on the nutritional status and development of inflammation in patients with elephantiasis	Data analysis completed	Intervention	2024-03-13	<NULL>	<NULL>	6852	Effects of dietary supplementation with different levels of Medium-chain Triglycerides on the nutritional status and inflammatory response of patients with Lymphatic Filariasis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal de Pernambuco	Instituto Aggeu Magalhães - Fiocruz Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-82rpdv9	<NULL>	Patients registered at the National Reference Service for Filariasis (Fiocruz-PE); residents in an endemic area for lymphatic filariasis; of both genders; aged between 18 and 85 years old, who had lymphedema of the lower limbs	Patients with edema or lymphedema due to liver diseases, neoplasms, congenital lymphatic alterations, cardiac and/or vascular insufficiencies, who, after medical screening, have no indication for follow-up at the Serviço de Referência Nacional em Filarioses (Fiocruz Pernambuco); patients who were already undergoing nutritional monitoring outside Fiocruz Pernambuco, or who had neurological and/or psychiatric diseases that could make it difficult to understand dietary guidelines; pregnant and/or lactating patients; patients who reported rejections, intolerances or allergies to the use of medium chain triglyceride oil as well as coconut oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-62kckb2	Study of Micrografting with a device for bone augmentation	Data analysis completed	Intervention	2024-03-15	<NULL>	<NULL>	6856	Use of bone and periosteal micrograft, associated to the xenograft, in vertical bone reconstruction with Barbell Technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-07	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	https://ensaiosclinicos.gov.br/rg/RBR-62kckb2	<NULL>	Patients of both genders; partially edentulous for more than 1 year; with absence of two teeth at least and at most five at the posterior maxilla (unilateral or bilateral); requiring implants in the posterior maxillary region with no more than 4 mm of remaining alveolar ridge; with need for maxillary sinus floor augmentation combined with onlay vertical bone augmentation in one or both sides; all patients should have between 18 and 65 years of age, with adequate oral health	Patients with a history of neoplastic disease treated with radiotherapy or chemotherapy; pregnant or breastfeeding; receiving treatment or affected by an illness that could influence on bone homeostasis; sinus pathologies; smokers; alcoholics; drug addicts	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-4ckch8	Comparative study between Laser therapy versus Pelvic Muscle Training in women with Stress Urinary Incontinence	Data analysis completed	Intervention	2020-01-07	<NULL>	<NULL>	6860	CO2 Laser Therapy versus Urogynecology  Physiotherapy  in SUI :  prospective randomized non inferiority study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-08	Faculdade de Ciência Médicas da Universidade Estadual de Campinas	Clínica Condé	https://ensaiosclinicos.gov.br/rg/RBR-4ckch8	<NULL>	Women with 18 years old or over; with sintoms of Stress Urinary Incontinence - SUI; with positive effort test or valsalva manouver and/or urodynamics findings of Stress Urinary Incontinence - SUI and residual volume less than 100 ml or 20 % of voided volume superior 300ml; in case of women with a negative stress test with anamnesis suggesting Stress Urinary Incontinence , women with a positive urodynamic study for Stress Urinary Incontinence will be included	Women with overactive bladder; or urodynamic finding of detrusor overactivity; women with repetitive  Urinary Tract Infection; woman with previous urogynecology surgeries; with previous treatment of radioterapy or Pelvic Organ Prolapse (POP) more than 2 years; women  with previous and recently history of bladder stone; urinary fistula  or divertíiculum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-8n3nxg8	Healthcare for Individuals with Leg Wounds related to circulatory problems: a study testing a treatment with various possibilities	Data analysis completed	Observational	2024-03-20	<NULL>	<NULL>	6877	Health care of people with Venous Ulcer: proposal for evaluation and multidimensional intervention	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8n3nxg8	<NULL>	Age equal to or greater than 18 years; be registered at any Primary Health Care unit covered by the service; present at least one active venous ulcer	Individuals with venous ulcers completely healed before the start of the study; those who did not attend appointments for more than one month; those who died or moved to a region outside the coverage area after the first collection; patients with mixed or non-venous leg lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-8gj3fkt	The effect of Electrical Stimulation on muscles in patients with Chronic Kidney Disease	Data analysis completed	Intervention	2024-04-01	<NULL>	<NULL>	6905	Neuromuscular Electrical Stimulation in patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal do Pará	Fundação Pública Estadual Hospital das Clínicas Gaspar Vianna	https://ensaiosclinicos.gov.br/rg/RBR-8gj3fkt	<NULL>	Volunteers diagnosed with Chronic Kidney Disease (CKD); performing hemodialysis on an outpatient basis; age greater than or equal to 18 years; both sexes; level of functioning with a score greater than or equal to 4 on the Johns Hopkins Highest Level of Mobility Scale (ability to transfer from a bed to an armchair); ability to understand study procedures	Volunteers with a pacemaker or implantable cardioverter-defibrillator; neuromuscular diseases; epilepsy; allergic reactions to electrodes; peripheral edema; ischemia in lower extremities; obesity with a body mass index greater than 35; symptomatic ischemic heart disease; history of myocardial ischemia and angina in the last 6 months; significant valvular heart disease or dysrhythmia; unstable medical condition due to acute or chronic illness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-2xxcvqj	Mild ovarian stimulation: lowest cost in vitro fertilization protocol to serve couples with difficulty to get pregnant at Hospital das Clínicas da USP	Data analysis completed	Intervention	2024-04-03	<NULL>	<NULL>	6916	Minimal Ovarian Stimulation: Low Cost In Vitro Fertilization Protocol for Infertile Couples at a University Center for Human Reproduction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-26	Hospital das Clínicas da Universidade Federal de São Paulo	Hospital das Clínicas da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xxcvqj	<NULL>	women aged up to 38 years; body mass index (BMI) up to 30 kg/m²; FSH dosage less than 10 mUI/ml; antral follicle count in the initial follicular phase higher than 5 follicles	sperm collection performed by any method other than masturbation, such as epididymal or testicular puncture; couples who did not agree with the Informed Consent Form (TCLE)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-3xdbk9q	Evaluation of the effect of Low Intensity Laser after Gingival Correction Surgeries	Data analysis completed	Intervention	2023-05-01	<NULL>	<NULL>	6918	Postoperative clinical evaluations of Low Intensity Laser in Gingival Smile Corrective Surgeries	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-28	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3xdbk9q	<NULL>	Patients of both sexes; over eighteen years of age; diagnosis of periodontal health on clinical examination; gingival exposure of three millimeter or more when smiling and surgical indication of at least two teeth in each hemiarch; patients without occlusal discrepancies and or premature contacts; individuals who underwent periodontal surgery or orthodontic treatment more than three months ago	Smokers and or alcohol drinkers; women who are pregnant or breastfeeding; patients requiring additional surgical, restorative and rehabilitative procedures that could influence the measurements performed in the study; patients with a history of maxillofacial cancer in the last five years; patients with uncontrolled systemic conditions; need for treatment due to infection; patients who make chronic use of antiinflammatories, analgesics or psychotropic drugs; patients who are allergic or have some idiosyncrasy to any component of the drugs used in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-377gqvx	Evaluation of the efficiency of a device for cramps resulting from oncological treatments	Data analysis completed	Intervention	2024-04-08	<NULL>	<NULL>	6926	Evaluation of the efficiency of an ionic load reduction device for Cramps arising from Chemotherapy-induced Peripheral Neuropathy (CIPN) and/or treatments inducing muscle ion overload and abrupt pH changes: a double-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-22	Associação de Combate ao Câncer de Goiás - ACCG	Associação de Combate ao Câncer de Goiás - ACCG	https://ensaiosclinicos.gov.br/rg/RBR-377gqvx	<NULL>	Patients of both genders; with Chemotherapy-Induced Peripheral Neuropathy (CIPN); and/or treatments causing an excess of ions in the muscles and abrupt changes in pH	Cramps related to the sciatic nerve; or a previous history of cramps; or weak and intermittent cramps	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-5r9xzbq	An Exergames or PhysicalEducation bouts benefits subsequent inhibitory control in Autism Spectrum Disorder children	Data analysis completed	Intervention	2024-04-15	<NULL>	<NULL>	6938	Acute effects of Exergames on the executive function of children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Católica de Brasília	Escola Classe 10 de Taguatinga	https://ensaiosclinicos.gov.br/rg/RBR-5r9xzbq	<NULL>	Those enrolled at Escola Classe 10 in Taguatinga/DF who were diagnosed with Autism Spectrum Disorder (ASD) according to the Diagnostic and Statistical Manual of Mental Disorders - DSM-5 (APA, 2014). No history of diseases such as physical, pulmonary or cardiac malformations. Boys and girls aged between 6 and 12	Non-verbalized Autism Spectrum Disorder (ASD); with intellectual impairment (IQ below 70); ages below 6 and above 12 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-6wjfmm7	Melatonin and how the body uses and transforms energy from food in Autism Spectrum Disorder	Data analysis completed	Intervention	2024-04-16	<NULL>	<NULL>	6943	Melatonin and energy metabolism in Autism Spectrum Disorder	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade Federal de São Paulo UNIFESP	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6wjfmm7	<NULL>	Patients with Autism Spectrum Disorder diagnosed according to the diagnostic criteria defined in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders; male gender; aged between ten and sixteen years and eleven months; patients using antipsychotic medication for at least one month; patients with mild intellectual disability with a global intelligence quotient between sixty nine and fifty or moderate intellectual disability with a global intelligence quotient between forty nine and thirty five	Patients who modified or discontinued psychotropic medication during the study; patients currently using melatonin or having used it within the last month; patients currently using medications from the beta blocker class and or currently using any benzodiazepine; patients diagnosed with amaurosis; patients diagnosed with early puberty; patients diagnosed with type one diabetes and or hypothyroidism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-83hc4bw	Effects of mate tea ingestion (Ilex paraguariensis) before aerobic exercise on metabolic, muscle damage and oxidative stress indicators	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6944	Effect of ingesting mate tea (Ilex paraguariensis) before exercise on energy metabolism and metabolic indicators	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-22	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-83hc4bw	<NULL>	Male; age between 18 and 35 years; regular practitioner of aerobic exercise; absence of metabolic diseases; no aversion or intolerance to study foods; not a user of tobacco, alcohol, supplements, or medications	Negative response to all questions in the Pre-activity Readiness Questionnaire (PAR-Q); below-average coronary risk; body fat percentage less than 25%; and Body Mass Index between 18.5 and 24.9 kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-2ymnqrr	Pain during filling using Tagger&apos;s Hybrid Technique in Endodontic Treatments	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6945	Pain during filling using Tagger&apos;s Hybrid Technique in Endodontic Treatments of necroses teeth in a single session, considering in association demographic data, dental group, periradicular status, treatment time and extravasation of filling cement	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-10	Associação Paranaense de Cultura - APC	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2ymnqrr	<NULL>	Patients with asymptomatic necrotic teeth with or without periapical lesions visualized radiographically, referred for endodontic treatments at the Dental Specialties Center of the Municipality of Navegantes – CEO/Navegantes – between the months of May 2023 to August 2023, after coronary access carried out in Basic Health Units (UBSs) through the use of spherical drills. 1014 or 1016, later using Tricresolformalin as an indwelling dressing. Age equal to or greater than 18 years old. Both genders	Patients with coronary and/or root perforations; periodontal involvement; spontaneous and/or acute or moderate painful symptoms upon percussion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-38c5f2h	Effectiveness of using a Customizable Healing Device for dental Implants: a Clinical Trial	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6947	Effectiveness of using a Customizable Healing Device for Immediate Implants in the posterior region: a Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-05-14	Fundação Universidade de Passo Fundo	Fundação Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-38c5f2h	<NULL>	Being indicated and extraction of posterior teeth and installation of dental implants; participants agree and sign the consent form; being in satisfactory health conditions to undergo treatment	Participants do not agree or do not sign the consent form; not being in systemic health conditions to carry out the treatment; failure to meet technical conditions for immediate dental implant installation after extraction. Teeth with furcation lesion or loss of gingival papillae will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-4xrx2g3	Reversal of muscle relaxation used in anesthesia: comparison of different doses of the reverser in children	Data analysis completed	Intervention	2024-04-25	<NULL>	<NULL>	6967	Comparison of the Effect of Different Doses of Neostigmine on Reversal of Rocuronium-Induced Neuromuscular Blockade in Children Undergoing General Anesthesia: Prospective Randomized Clinical Trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4xrx2g3	<NULL>	children aged 2 to 10; classified as American Society of Anesthesiologists (ASA) physical status I and II; undergoing general anesthesia for tonsillectomy with or without adenoidectomy	refusal to participate in the study; presence of renal disease; presence of hepatic disease; presence of neuromuscular disease; contraindication to the use of any of the drugs used in the study; body mass index equal to or greater than 30; acute clinical illnesses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-32c43kw	Impact of abreviation of preoperative fasting on cost-effectiveness in surgical patients	Data analysis completed	Observational	2024-04-29	<NULL>	<NULL>	6977	Impact of ACERTO Protocol in cost-effetiveness in surgical patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-32c43kw	<NULL>	This is a retrospective study; collecting data from patients admitted to the surgical clinic ward at the Julio Muller University Hospital (HUJM) in the city of Cuiabá – MT; of both sexes; during the period from January 2019 to December 2019	Pregnant women; and children under 18 years of age; and those whose medical records did not have sufficient information	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-7cf5tmv	Laser effects in women with vocal disorders	Data analysis completed	Intervention	2024-05-07	<NULL>	<NULL>	6988	Immediate effects of low-intensity Laser Photobiomodulation in women without vocal complaints and in dysphonic women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-24	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7cf5tmv	<NULL>	Vocally healthy participants - women aged 18 to 45; no vocal complaints or laryngeal injuries; neutral vocal quality. Dysphonic participants - women aged 18 to 45; with complaints or altered vocal quality or diagnosis of benign lesions of the larynx	Pregnant women; women in the premenstrual period; with an allergic reaction, and/or respiratory condition on the day of the assessment; with a systemic, neurological, and/or neoplastic disease; smokers; women who had been previously submitted to speech-language-hearing and/or surgical treatment due to voice changes; who were photosensitive or had a skin disease/lesion; who had a tattoo in the region where light would be applied; and those who reported taking skin treatment medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-104gykws	Reduction in sedentary lifestyle after stroke	Data analysis completed	Intervention	2024-05-07	<NULL>	<NULL>	6990	Reducing sedentary behavior after stroke	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Hospital Municipal São José	Hospital Municipal São José	https://ensaiosclinicos.gov.br/rg/RBR-104gykws	<NULL>	Individuals aged 18 years or over; of both sexes; capable of walking independently or with supervision able to use an assistive device; diagnosed with a stroke; clinically stable and accepting to participate in the research by signing the Free Consent Form and Clarified TCLE	Individuals with severe cognitive impairment; severe aphasia; walking dependent on assistance from another person or unable to walk; severe heart disease; and impossibility of telephone contact after hospital discharge	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-4nkyrct	Impact of not removing bubbles generated during in-office bleaching in adult patients: Single-blind, split-mouth, randomized clinical trial	Data analysis completed	Intervention	2024-05-08	<NULL>	<NULL>	6995	Impact of not removing bubbles generated during in-office bleaching in adult patients: Single-blind, split-mouth, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Elder Jossué Romero López	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4nkyrct	<NULL>	Age from 18 years old; regardless of sex; have good general and dental health conditions; upper teeth free of cavities and upper front teeth free of restorations on the buccal surface; in addition to central incisors showing C2 or darker color; evaluated in comparison with a visual color scale guided by the value of the teeth	Pregnant or breastfeeding women; users of fixed orthodontic appliances; with pre-existing previous restorations; presence of severe intrinsic stains on the teeth; participants with a previous history of tooth sensitivity or any associated pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-9gzgpb	Evaluation of the Efficacy of Dipyrone, administered before the surgical incision, in postoperative Pain after Tonsil and Adenoid surgeries in children	Data analysis completed	Intervention	2019-10-14	<NULL>	<NULL>	7004	Evaluation of the efficacy of Dipirone in Preemptive Analgesia through decreasing pain after Adenotonsylectomy operation in children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-27	Hospital da Criança Santo Antônio	Hospital da Criança Santo Antônio	https://ensaiosclinicos.gov.br/rg/RBR-9gzgpb	<NULL>	Children between 4 and 14 years old, ASA (American Society of Anesthesiology) physical status I (healthy patient) and II (patient with mild illnesses); with scheduling of first tonsillectomy surgery with or without adenoidectomy; who had a consent form signed by the responsible person and the consent form, when necessary.	Those patients who had already undergone adenoidectomy surgery; with any chronic illness that requires daily fixed analgesia; with developmental delay; who did not understand the Portuguese language, who did not have parents living with them and those who perhaps they did not accept participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-2zz8cg8	Shock waves in knee extension of individuals with Cerebral Palsy	Data analysis completed	Intervention	2024-05-15	<NULL>	<NULL>	7005	Effect of shock waves on knee range in individuals with Cerebral Palsy: case study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Centro de Estudos da Educação e Saúde - CER II - Universidade Estadual Paulista	Centro de Estudos da Educação e Saúde - CER II - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2zz8cg8	<NULL>	Ter idade entre 3 e 12 anos, com diagnostico de Paralisia Cerebral diparética espástica; não ter recebido tratamento prévio de toxina botulínica ou cirúrgico nos seis meses que antecederam a primeira coleta; apresentar grau três ou quatro de espasticidade classificada pela Escala Modificada de Ashworth; apresentar classificação II, III ou IV no Sistema de Classificação da Função Motora Grossa - GMFCS	Two absences during the protocol application period; presenting pain in the lower limbs that makes shock wave therapy unfeasible and assessment protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-6rzh4h2	Effectiveness of Dry needling as a treatment for long lasting Tinnitus	Data analysis completed	Intervention	2024-05-22	<NULL>	<NULL>	7018	Effectiveness of Dry needling as a treatment for Chronic tinnitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Hospital Edmundo Vasconcelos / Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	Hospital Edmundo Vasconcelos / Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	https://ensaiosclinicos.gov.br/rg/RBR-6rzh4h2	<NULL>	Patients over 18 years old; tinnitus for at least 3 months; trigger points on physical examination	Pulsatile tinnitus; coagulopathy or anticoagulant use; dermatological lesion at the needling site; pregnancy; needle phobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4ttb63q	Clinical study of nuclear alterations in patients undergoing in-office tooth whitening	Data analysis completed	Intervention	2024-05-24	<NULL>	<NULL>	7022	Evaluation of the genotoxic potential of dental whitening in patients with different age groups: clinical study	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade de Odontologia - Universidade Federal do Amazonas	Faculdade de Odontologia - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4ttb63q	<NULL>	Both sexes; age between 14 and 18 years old and 31 and 50 years old; no systemic diseases (metabolic, immunological and heart diseases); with oral condition free from carious lesions or periodontal diseases; central incisor or canine color A2 or darker; six upper anterior teeth free of restorations on the buccal surface; healthy enamel; dissatisfaction with the color of your teeth; no pathological changes; physiological and medicinal	Dentin hypersensitivity; smoker; alcoholic; pregnant or breastfeeding; orthodontic appliance; severe crowding, presence of intrinsic spots and ages between 19 and 30 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-39szpm6	Effect of several pre-exercise interventions on physical performance	Data analysis completed	Intervention	2024-05-27	<NULL>	<NULL>	7028	Different pre-exercise strategies on physical performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-03	Instituto de Ciências Biológicas da Universidade Federal de Juiz de Fora	Instituto de Ciências Biológicas da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-39szpm6	<NULL>	Healthy subjects; Age between 18 and 40 years old; male; experience with resistance exercise of at least one year	Smoking history; presence of any metabolic or cardiovascular disease; arterial hypertension (≥140/90 mmHg or use of antihypertensive medications); use of anabolic steroids, drugs or medications with potential impact on physical performance; recent musculoskeletal injury; previous experience with pneumatic occlusion intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-6d3mxjw	Effects over time of arm therapy for children with cerebral palsy	Data analysis completed	Intervention	2024-06-03	<NULL>	<NULL>	7039	Long-term effects of constraint-induced movement therapy in the hemiparetic upper limb use in children with cerebral palsy between two and ten years of age	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Departamento de Fisioterapia da Universidade Federal de São Carlos	Departamento de Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6d3mxjw	<NULL>	Have a diagnosis of hemiplegic cerebral palsy; gross motor function level one to three; manual function level one to three; score on the pediatric manual upper limb scale with an average score less than two and a half	Have cognitive or visual impairment; be allergic to the cast material; have behavioral problems that compromise the application of therapy; be undertaking other intensive training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-4t2hqqt	Effect of Calcium Hypochlorite in Endodontic Treatment	Data analysis completed	Intervention	2024-06-03	<NULL>	<NULL>	7040	Effect of Calcium Hypochlorite as an irrigating solution in Endodontic Treatment: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4t2hqqt	<NULL>	Healthy patients; both genders; age between 18 and 60 years;need for endodontic treatment; asymptomatic	Use of antibiotics, anti-inflammatories or analgesics for at least 7 days before the procedures; preoperative pain; teeth with incompletely formed apices; calcified root canals; periodontal probing greater than 3 mm; persistent exudate at the time of filling; immunosuppression or immunocompromised	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-38gcwz9	Collagen Matrix vs. Connective Tissue Graft for peri-implant soft tissue augmentation	Data analysis completed	Intervention	2024-06-24	<NULL>	<NULL>	7091	Stability of subepithelial Connective Tissue Graft or volumetrically stable Collagen Matrix for ridge volume augmentation: split-mouth randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	FAESA-Centro Universitário Espíritosantense	FAESA-Centro Universitário Espíritosantense	https://ensaiosclinicos.gov.br/rg/RBR-38gcwz9	<NULL>	Good oral hygiene with visible plaque index less than 20%; age higher or equal to 18 years; both genders; sufficient tissue availability to harvest an autogenous soft tissue graft from the palate with 12 mm width, 8 mm height, and 2 mm of thickness; soft tissue at the implant site with a thickness inferior to 2 mm; an implant installed for at least 3 months in both sides of the posterior mandible; need for reopening procedure in the implants	Systemic alterations; presence of inflammation or infection involving the regions where the surgical procedures were performed; bone pathology in the implant site; smoking; excessive use of alcohol; drug addiction; diabetes; pregnancy or desire to become pregnant in the next year; history of radiotherapy treatment in the head and neck region, and people who take medications that may interfere with bone remodeling or who have pathologies that affect bone metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-8dz9zvq	Tooth sensitivity in different dental arches after in-office dental whitening	Data analysis completed	Intervention	2024-06-24	<NULL>	<NULL>	7092	Tooth sensitivity of in-office dental whitening in different arches: a randomized clinical trial	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8dz9zvq	<NULL>	Patients at least 18 years old; both genders; with good oral and general health; have their maxillary anterior teeth free from restorations, carious lesions, gingival recessions or periodontal disease; canines with color A2 or darker according to the Classical Vita scale (Vita Zahnfabrik, BadSäckingen, Germany); to agree with the free and informed consent form	Previous dental whitening; previous tooth sensitivity; pregnant or breastfeeding women; severe tooth darkening (tetracycline staining; fluorosis or endodontics); previous dental restorations; previous endodontic treatment; visible cracks; dentures or orthodontic appliances; oral pathologies; bruxism; smokers; patients with gastric, cardiac, renal or hepatic problems; diabetics; hypertensive patients; continuous use of analgesic and anti-inflammatory medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4dh99pj	Transcranial direct current stimulation associated with physical exercise in smokers on craving	Data analysis completed	Intervention	2024-06-26	<NULL>	<NULL>	7104	Effects of transcranial direct current stimulation on craving in the cortex prefrontal associated with physical exercise in smokers.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-14	Universidade Federal de Alagoas	Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL	https://ensaiosclinicos.gov.br/rg/RBR-4dh99pj	<NULL>	Being male or female; being addicted to nicotine for more than 2 years; be between 25 and 55 years old	Substance abuse or dependence other than nicotine dependence; diagnosis of mental disorder, epilepsy, seizures, delirium tremens, chronic obstructive pulmonary disease; use of psychotropic medication; being in treatment to stop smoking; have any contraindication to electrical brain stimulation procedures, such as electronic implants or metal implants in the head; being in a gestational state; present physical and/or physiological problems that interfere with participation in a moderate-intensity physical exercise program; present moderate or high risk for physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-2q4ht7r	Bicalutamide associated with oral Minoxidil for the treatment of female baldness	Data analysis completed	Intervention	2024-07-01	<NULL>	<NULL>	7114	Efficacy and safety of Bicalutamide 25 mg associated with Minoxidil 1 mg oral versus Minoxidil 1 mg oral for treating female pattern Alopecia: double-blind and randomized clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-09-12	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2q4ht7r	<NULL>	Patients diagnosed with Female Pattern Alopecia (stages II, III, IV and V of the Sinclair Scale); patients with a minimum age of 18 years and a maximum age of 60 years; female patients	Any type of previous alopecia treatment in the past 4 months; patients with diagnosis of Systemic Arterial Hypertension; cardiopaths patients; hepatophats patients; nephropats patients; patients with any other cause of hair loss besides Female Pattern Hair Loss; patients with pregnancy intention in the next 12 months; patients in fertile age that wont agree in the use of secure contraceptive methods; patients who, during the clinical trial, present an increase in liver enzymes greater than two and a half times the upper limit of normality	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-2p4mz5	Effects of a training protocol for breathing musculature in patients undergoing coronary artery bypass grafting	Data analysis completed	Intervention	2018-05-02	<NULL>	<NULL>	7121	Effects of a respiratory muscle training protocol with POWERBreathe® in patients undergoing coronary artery bypass grafting with with extracorporeal circulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Alfenas - UNIFAL MG	Hospital e Maternidade Santa Lúcia - Hospital do Coração	https://ensaiosclinicos.gov.br/rg/RBR-2p4mz5	<NULL>	Individuals with coronary artery disease with elective indication for myocardial revascularization with extracorporeal circulation; age 18 and over,with a maximum limit of 80 years;of both sexes; who are able to perform physical and respiratory tests; in addition to having signed the consent form	Individuals presenting a diagnosis of neurological and / or cognitive impairment, neuromuscular diseases, history of previous pulmonary surgery; associated heart surgery; presence of aneurysm; in use of muscle relaxants in the preoperative period and present cardiovascular instability during the preoperative evaluation period and during the postoperative protocol; individuals who can not perform the necessary procedures; quit participating in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-9sfj4rz	Evaluation of Photobiomodulation in topical anesthetic absorption and pain reduction during Local Infiltrative Anesthesia	Data analysis completed	Intervention	2024-07-09	<NULL>	<NULL>	7126	Use of Photobiomodulation to help in the absorption of topical anesthetics and reduction of pain during Local Infiltrative Anesthesia in the dental clinic	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2022-10-30	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9sfj4rz	<NULL>	Patients who require at least 2 infiltrative anesthesias to carry out their dental treatment plan. Anterior teeth or premolars. Patients without systemic impairment. Patients aged between 18 and 50 years. Both genders	Patients who are undergoing antidepressant or antipsychotic drug treatments. Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-3mywq86	Effect of Non-Invasive Neuromodulation in improving balance and gait of individuals with Parkinson´s disease	Data analysis completed	Intervention	2022-08-26	<NULL>	<NULL>	7129	Effectiveness of Transcranial Direct Current Stimulation associated with Physiotherapy in improving balance and gait of individuals with Parkinson´s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-30	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-3mywq86	<NULL>	Medical diagnosis of Parkinson&apos;s disease according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria); age range between 50 and 85 years; not institutionalized; mini-mental score that does not characterize cognitive impairment; Hoehn&amp;Yahr scale between 1.5 and 3.0; which accept to participate of the project and sign the consent term according to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (National Health Council)	Individuals who perform another therapeutic treatment beyond medication; that has change in medication during the study; or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive or understanding deficits. Change in the stabilization of the antiparkinsonian medication doses throughout the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-8hcb95v	Effect of Coconut Oil on Vaginal Hydration after Exposure to Cancer Treatment	Data analysis completed	Intervention	2024-07-24	<NULL>	<NULL>	7150	Evaluation of the effect of coconut oil as a vaginal restructuring agent for patients undergoing chemotherapy and radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-26	Centro Universitário CESMAC	Centro Universitário CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-8hcb95v	<NULL>	Women with a confirmed diagnosis of cancer (all types) undergoing chemotherapy or radiotherapy; between 18-50 years old; with an active sexual life; who agree to the Informed Consent Form of this research	Women with secondary amenorrhea or menopause will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6x32np2	Evaluation of the applicability of membranes of poly ɛ- caprolactone charged with drugs in the treatment of wounds	Data analysis completed	Intervention	2024-07-24	<NULL>	<NULL>	7152	Effectiveness of the controlled release of poly ɛ-caprolactone membranes obtained by electrospinning in treating complex wounds, free from infection, in patients with vascular diseases with or without surgical treatment: randomized, comparative study and control	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2019-07-26	Universidade Federal do Amazonas	Hospital Pronto Socorro 28 de Agosto	https://ensaiosclinicos.gov.br/rg/RBR-6x32np2	<NULL>	Patients aged 18 or older; legally responsible; presenting clean wounds in the granulation phase; admitted to the Emergency Hospital; assisted by the Hospital Infection Control Committee unit of the facility	Patients with the need of surgical treatment; those undergoing antibiotic therapy; presenting difficult-to-control hyperglycemia above 300 mm/dL; peripheral arterial obstructive disease; venous hypertension; chronic venous insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-34h937k	General, systemic and cerebral ffects of Photobiomodulation	Data analysis completed	Observational	2024-07-29	<NULL>	<NULL>	7163	Systemic, integral and integrated effects in Transcranial Photobiomodulation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-10	Universidade Anhembi Morumbi	Universidade Anhembi Morumbi	https://ensaiosclinicos.gov.br/rg/RBR-34h937k	<NULL>	Healthy women; age between 18 and 60 years old; teachers, taking into account the complaint of vocal fatigue reported and identified in a previous vocal screening exam carried out by the author	Male teachers and those who were unable to perform the voice emission collection due to difficulties in understanding and/or inherent to the practice of the exam were exclude	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-7h672c9	Effect of Pilates on strength and movement in Crossfit practitioners	Data analysis completed	Intervention	2024-07-29	<NULL>	<NULL>	7165	Effect of Pilates on strength and range of movement in extreme conditioning practitioners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal do Triangulo Mineiro	Universidade federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7h672c9	<NULL>	Individuals of both sexes; Age 18 or over years; Healthy; Practicing extreme conditioning program (ECP) for at least month; Who are enrolled and present at these academies on the day of the assessment; Agree to participate in the research and sign the Informed Consent Form	Beginners who do not attend the reevaluation; Beginners who stop practicing the activity during the study; Volunteers who experience discomfort or restrictions when performing any of the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8c5cjmg	Effects of a Brain Reprocessing Psychotherapy in treating Obesity in adolescents: a quali-quantitative approach	Data analysis completed	Intervention	2022-08-03	<NULL>	<NULL>	7174	Effects of Brainspotting in treating Obesity in adolescents: a quali-quantitative approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8c5cjmg	<NULL>	Adolescents with exogenous obesity; Body Mass Index (BMI) z score &gt;2; both genders; aged between 10 and 19 years old; followed up by obesity ambulatory at Nutrology Discipline of São Paulo Federal University’s pediatrich department	Adolescents with pathology that causes difficulties of comprehension, difficulties of reasoning and cognitive deficit; cardiac, neurologichal and psychiatric patologies diagnosis in wich is not recommended the intervation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-2n5b5y3	Comparison between Femoral Nerve Anesthesia and Adductor Canal Anesthesia in analgesia and mobility in patients undergoing Revision knee prosthesis surgery randomized controlled clinical trial	Data analysis completed	Intervention	2024-08-08	<NULL>	<NULL>	7189	Comparison between Femoral Nerve Block and Adductor Canal Block in analgesia and mobility in patients undergoing Revision total knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-25	Ministério da Saúde	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-2n5b5y3	<NULL>	Patients undergoing total knee arthroplasty revision surgery; both sexes; older than 18 years; classified by the American Society of Anesthesiology (ASA) as physical status I to III	Patients with daily consumption of opioids and/or antidepressants; patients in whom it was necessary to perform general anesthesia; patients with neurological and muscular diseases; patients allergic to dipyrone, tramadol and local anesthetics; bedridden and amputated patients; and patients with grade III obesity (BMI &gt; 40)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8stsfvp	Assessment of dental stabilizing devices at the dental trauma clinic: a clinical study within the unified health system	Data analysis completed	Observational	2024-08-09	<NULL>	<NULL>	7197	Evaluation of dental splints at the dental trauma clinic: a clinical study in the SUS environment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-30	Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8stsfvp	<NULL>	Patient referred to the Dental Trauma Clinic at the Dental Hospital of the Federal University of Uberlândia; patient with permanent traumatized tooth; both gender;  patient with dental splint; patient aged 6 years and above	Patients with traumatized primary teeth; patients under 6 years old; patients who can not attend follow-ups	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:19
RBR-10ths4s7	Open, randomized clinical trial: the efficacy of mindfulness intervention on the mental well-being of patients had COVID-19	Data analysis completed	Intervention	2024-08-13	<NULL>	<NULL>	7213	Open, randomized clinical trial: the efficacy of mindfulness intervention on the mental well-being of post-COVID 19 patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-27	Instituto Nacional de Infectologia Evandro Chagas - INI / FIOCRUZ	Instituto Nacional de Infectologia Evandro Chagas - INI / FIOCRUZ	https://ensaiosclinicos.gov.br/rg/RBR-10ths4s7	<NULL>	Over 18 years old and of both sexes; Provide signed free and informed consent for yourself if legally capable, or by your legal representatives for those who do not have legal capacity; Agree to participate in all study visits, procedures and contacts; Post-COVID-19 symptoms (14 days to 12 months from the date of onset of symptoms, with positive antigen PCR or RT-PCR naso/oropharyngeal swab) directly related to Mental Health	Patients with hearing restrictions, with technological restrictions and without post-COVID-19 sequelae	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3t2rmfs	Evaluation of different anesthetic techniques during the aesthetic application of botulinum toxin in the upper third of the face: randomized clinical trial	Data analysis completed	Intervention	2024-08-13	<NULL>	<NULL>	7214	Evaluation of different Anesthetic Techniques in Orofacial harmonization procedures: randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-01-06	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3t2rmfs	<NULL>	Female patients, aged over 18 years, systemically healthy, with no previous history of botulinum toxin application in the upper third of the face and who presented dynamic wrinkles in the upper third of the face.	Patients with abusive use of alcohol or illicit drugs, moderate smokers (&gt; 10 cigarettes/day), history of facial surgery, pregnant or breastfeeding, pre-existing disorders that affect neuromuscular function (such as myasthenia gravis, motor neurone disease), infections locals, undergoing remote or recent (&lt; 2 years) laser, radiotherapy or chemotherapy treatment in the orofacial region, who continuously take medications that may affect the metabolism of inflammatory mediators, and who are hypersensitive or allergic to botulinum toxin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:59
RBR-2dbpbjf	Comparative study of ways of positioning the head for computer planning of surgeries to correct facial deformities	Data analysis completed	Observational	2024-08-20	<NULL>	<NULL>	7237	Comparative study of head orientation methods using different software for virtual planning of orthognathic surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do RIo Grande do Norte	Universidade Federal do RIo Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2dbpbjf	<NULL>	Inclusion criteria were patients who were candidates for orthognathic surgery, including patients who underwent one- or multi-piece Le Fort one osteotomy, bilateral sagittal split osteotomy, and genioplasty, without significant asymmetries.	Exclusion criteria were patients undergoing temporomandibular joint (TMJ) reconstruction surgery, patients with TMJ pain, limited mouth opening and condylar resorptions, patients with any syndromic disorder, and patients with any lip and palate or facial cleft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-458mtdb	Effect of reiki on the subjective well-being of nursing professionals in an emergency: randomized clinical trial	Data analysis completed	Intervention	2024-08-21	<NULL>	<NULL>	7244	Evaluation of the effect of reiki on the subjective well-being of nursing professionals in emergency services: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-458mtdb	<NULL>	Both genders; minimum age of 18; nursing professionals with at least three months work in the unit	Nursing professionals who are away for various reasons (vacation, leave, health, pregnancy); those who are merely replacing another professional in the unit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-89w7hc2	Cortical activity assessment and the use of Virtual Reality for rehabilitation and cortical activity assessment in patients who had stroke episodes	Data analysis completed	Intervention	2024-08-26	<NULL>	<NULL>	7276	Cortical connectivity assessment and Virtual Reality intervention for rehabilitation of stroke patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Instituto de Física Gleb Whatagin	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-89w7hc2	<NULL>	Patients who suffered a stroke (type 1); patients who have hemeparesis as a consequence of the stroke; both female and male gender patients; patients above 18 years old	Patients who are confused and disoriented; patients who have comprehension aphasia; patients without any motor deficit; patients who have claustrophobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-2w5gczv	Cardiopulmonary resuscitation training: how practice in simulations can contribute improve cardiopulmonary arrest care	Data analysis completed	Intervention	2024-08-28	<NULL>	<NULL>	7286	Learning, satisfaction and self-confidence of nursing professionals submitted to different teaching methods (traditional or realistic simulation) of cardiopulmonary resuscitation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Fundação Cristiano Varella	Fundação Cristiano Varella	https://ensaiosclinicos.gov.br/rg/RBR-2w5gczv	<NULL>	Nursing professionals recently hired by the institution, within up to 90 days of admission; both genders; aged between 19 and 47 years	Incomplete filling out of assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-10gbvjyb	Effect of creatine supplementation on physical performance in physically active women	Data analysis completed	Intervention	2024-08-28	<NULL>	<NULL>	7291	Effects of Creatine Supplementation on Muscle Strength during a Session of Concurrent Training on active women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10gbvjyb	<NULL>	Being female. Have a normoprotein or hyperprotein diet; Be a practitioner of physical exercise (at least three times/week strength training and at least once/week aerobic exercise); recent strength and aerobic training experience of at least six months; age between 19 and 59 years old	Use of a creatine supplement in the last six months; being using anabolic steroids or steroids; being taking medications that can affect muscle biology (corticosteroids); have kidney disease; have liver disease; be allergic to milk; eggs and/or soy (according to the creatine marketer&apos;s instructions); perform some additional physical exercise that is not part of your daily routine before the protocol; take anti-inflammatories (medication) during the current study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-6s332z3	Malignant Hyperthermia and Kidney Transplantation	Data analysis completed	Observational	2024-08-28	<NULL>	<NULL>	7292	Anesthesia for Malignant Hyperthermia in the context of Kidney Transplantation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-10-05	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6s332z3	<NULL>	Patients scheduled for living donor kidney transplantation; living patients scheduled for total nephrectomy for donation; both sexes	Patients with a previous history of intraoperative awakening; family or personal history of susceptibility to malignant hyperthermia (MH); contraindications to the use of halogenated inhaled anesthetics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-23t5jbh	Modification of Frailty status in older adults: effect of Bodyweight Interval Exercise	Data analysis completed	Intervention	2024-09-04	<NULL>	<NULL>	7311	Modification of Frailty status in older adults: efficacy of Bodyweight Interval Training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23t5jbh	<NULL>	Older people aged sixty years or older; scoring on one or more components of the self-reported frailty screening tool; preserved mobility; availability to engage in training three times a week; signing the informed consent form	Present a medical diagnosis of dementia; psychiatric disorders; mental disability; medical diagnosis of stroke with severe impairment; physical impairment that prevents mobility; unavailability to attend training sessions three times a week; not scoring on at least one component of the self-reported frailty screening tool	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-787ykrm	Body responses to Exercises of three different Intensities, acute and chronic	Data analysis completed	Intervention	2024-09-04	<NULL>	<NULL>	7314	Physiological, Biochemical, and Immunological responses to High, Moderate, and Low Intensity Exercises acutely and chronically	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade do Extremo Sul Catarinense	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-787ykrm	<NULL>	Present the signed Informed Consent Form (TCLE); be available to perform exercises three times a week; suit the age for each group between 20 and 40 years old; present a medical certificate authorizing participation; masculine gender	Give up before the intervention is due to complete; have a problem (physical) that makes it impossible to continue activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-9j49xsg	Effect of anesthesia on abdominal wall during video surgery in patients undergoing intestinal resection: a double-blind, randomized clinical study	Data analysis completed	Intervention	2024-09-06	<NULL>	<NULL>	7321	Analgesic effect of laparoscopic-guided transversus abdominis plane block (TAP block) in laparoscopic colorectal surgery: a randomized, double-blinded trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2021-08-09	Hospital Governador Israel Pinheiro	Hospital Felício Rocho	https://ensaiosclinicos.gov.br/rg/RBR-9j49xsg	<NULL>	Volunteers with an indication for segmental colon resection; aged 18 years or older; elective surgical proposal; laparoscopic surgery proposal; both sexes	Volunteers with pre-anesthetic assessment ASA IV-V; a history of allergic reactions to local anesthetics; complaints of chronic pain, chronic opioid use, or opioid tolerance; the need for resection of organs other than the colon, rectum, and/or cecal appendix; preoperative signs of intestinal obstruction; surgical indication for laparotomy access; signs of inflammation or infection at the TAP block puncture sites; surgeries for the treatment of neoplastic recurrence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-104qh4qd	Effect of Abdominal Massage in People with Anxiety and Stress	Data analysis completed	Intervention	2024-09-12	<NULL>	<NULL>	7338	Effect of Visceral Mobilization in patients with Anxiety and Stress Symptoms: a double-blind, randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-16	Colégio Brasileiro de Osteopatia	Universidade de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-104qh4qd	<NULL>	Self-reported symptoms of anxiety and/or stress; age between 18 and 60 years; regardless of sex	Presence of incision or tumor in the abdominal region; presence of fractures, rheumatic pathologies or infection in the acute phase; impossibility of understanding the proposed assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-4r4fync	Quality of recovery and postoperative pain in patients undergoing gallbladder removal laparoscopic surgery under low pneumoperitoneum pressure versus standard pressure with moderate or deep neuromuscular block. Randomized controlled study	Data analysis completed	Intervention	2024-09-16	<NULL>	<NULL>	7347	Quality of recovery and postoperative pain in patients undergoing laparoscopic cholecystectomy under low pneumoperitoneum pressure versus standard pressure with moderate or deep neuromuscular block. Randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina de Jundiaí	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-4r4fync	<NULL>	Patients aged between 18 and 65 years; both genders; physical status by the American Society of Anesthesiology I or II;  who will undergo Laparoscopic Cholecystectomy at the Regional Hospital of Jundiaí (Jundiaí-SP) performed on an elective basis	Patient refusal; altered level of consciousness or inability to communicate; presence of contraindication to the use of any agent described in the project; history of alcohol or drug abuse; Body Mass Index greater than or equal to 40; presence of chronic pain or opioid use; presence of neuromuscular disease; history of complicated cholelithiasis such as acute cholecystitis, cholangitis, or pancreatitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-3vkjyvy	Efficiency of weight loss support for patients with excess body weight and other diseases that pose a risk to heart health	Data analysis completed	Intervention	2024-09-19	<NULL>	<NULL>	7358	Effectiveness of a weight loss program for obese patients with cardiovascular risk factors	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Instituto Dante Pazzanese de Cardiologia do Estado de São Paulo	Instituto Dante Pazzanese de Cardiologia do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3vkjyvy	<NULL>	Being a patient at the Dante Pazzanese Institute of Cardiology-SP; of both genders; be aged ≥ 19 years; agree to participate in the study and have consented and signed the informed consent form	Pregnant patients; patients with liver disease; in the pre-transplant period; diagnosed with chronic kidney disease; oncology, diagnosed with heart failure; atrial fibrillation; with pacemakers and with bundle branch block	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-4bv89x8	Effect of a prenatal program on child development among babies exposed to Covid-19 in utero	Data analysis completed	Intervention	2024-09-21	<NULL>	<NULL>	7364	Exposure to SARS-Cov-2 and child development in the first year of life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-15	Instituto de Ensino e Pesquisa Alberto Santos Dumont	Universidade Estadual de Campinas -UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-4bv89x8	<NULL>	Inclusion criteria for both groups included singleton pregnancies followed at the Anita Garibaldi Health Center; minimum age 18 years; absence of confirmed or suspected fetal congenital infection or chromosomal anomalies; no serious illness or complications during pregnancy; and no substance use disorder	Failure to complete the follow-up during the first year after birth at the clinic; neonatal death; and extremely preterm (less than 28 weeks) or very preterm (less than 32 weeks) infants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6rgr4gp	Chest physiotherapy in infants with Acute Viral Bronchiolitis	Data analysis completed	Intervention	2024-09-23	<NULL>	<NULL>	7366	Phydiotherapeutic intervention in infants with Viral Bronchiolits moderate acute	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-19	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6rgr4gp	<NULL>	Infant patients; of both sexes; from 1 day of life to 12 months of age; admitted to the pediatric wards at the Hospital de Clínicas do Complexo Hospital de Clínicas; with no history of hospitalizations; with a clinical diagnosis and classified as moderate in the Acute Viral Bronchioitis score; which guardians agree to adhere to the Informed Consent Form	Infants who present hemodynamic instability; classified as mild or severe in bronchiolitis scores; prematurity; lung malformation; bronchopneumonia; congenital heart defects; with a history of hospitalizations for other pathologies; refusal of family members or guardians and failure to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-8mj25hx	Nanotechnology eye drops for the treatment of dry eye: a multicenter and prospective study	Data analysis completed	Intervention	2024-09-24	<NULL>	<NULL>	7371	Phospholipid nanoemulsion-based ocular lubricant for the treatment of dry eye subtypes: a multicenter and prospective study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-30	Cetos, Pesquisa Diagnóstico e Tratamento Oftalmológico LTDA	Cetos, Pesquisa Diagnóstico e Tratamento Oftalmológico LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8mj25hx	<NULL>	Participants 18 years of age or older of both sexes; Ability to understand and analyze the free and informed consent form; Able and willing to attend all study visits; Present a TFBUT bigger than 5 seconds in at least one eye; Dry eye symptoms with Ocular Surface Disease Index questionnaire bigger than 13 points; Present at least one of the 3 criteria below in at least one of the eyes: Schirmer test score I less than 9 mm; Meibomian transparency quality score bigger than 1 (on a scale of 0 to 3) or meibomian gland expressibility score bigger than 1 (on a scale of 0 to 3); Patients who completed the competitions mentioned in the first 2 items; Best corrected visual acuity bigger than 20/80 in both eyes; Have mild to moderate dry eye; Be willing to discontinue use of all artificial tear supplements and only use the study product as directed throughout the entire duration of the study	Patients who meet any of the criteria listed below during the screening visit will be excluded from participation in this study: History of hypersensitivity to the study drug or any component related to the study product; Use of any topical ocular medication preserved with benzalkonium chloride or other product known to be toxic to the tear lipid layer one month prior to the study screening visit; Start of eye hygiene 4 weeks before the screening visit; History of malignancy in any organ treated or not within an interval of less than 5 years; Eye abnormalities that may compromise the safety and effectiveness of treatment, such as: Eyelid abnormalities that compromise blinking and complete eyelid closure; Corneal diseases such as ulcers, abrasions, keratoconus or dystrophies, which may be active or affect vision; Metaplasia of the ocular surface; history of recurrent corneal erosion; evidence of corneal neovascularization; history of herpes simplex keratitis or zoster; uncontrolled systemic disease; eye infection; participation in any clinical study less than 30 days prior to the screening visit; tear punctum plug insertion or any procedure 30 days prior to the screening visit; initiation of use or change in dose of systemic medications (antihistamines, anti-depressants, anti-psychotics and benzodiazepines) that may cause dry eye 30 days before the screening visit; use of contact lenses within one week of the screening visit; history of ocular surgeries within 6 months prior to the screening visit; start of any topical ocular medications 2 weeks prior to treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-3dbxrc2	Prevention of Child Obesity in Primary Health Care of the metropolitan region of Vitória/ES	Data analysis completed	Intervention	2024-10-02	<NULL>	<NULL>	7393	Prevention of Child Obesity in Primary Health Care: a community essay in the metropolitan region of Vitória/ES	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-17	Centro de Ciências da Saúde - Universidade Federal do Espírito	Centro de Ciências da Saúde - Universidade Federal do Espírito	https://ensaiosclinicos.gov.br/rg/RBR-3dbxrc2	<NULL>	Families with children aged 7 to 10 years; both genders; registered in the Family Health Units of the four participating municipalities	Children with cognitive disabilities that make it impossible to answer the questionnaires and/or participate in educational activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-8rwyp5g	Effects of an educational intervention aimed at Community Health Agents (CHA) about rights in maternal and child health	Data analysis completed	Intervention	2024-10-03	<NULL>	<NULL>	7400	Involving Users to Improve the Quality of Services and Guarantee Rights: strengthening the maternal and child health care system in the first 1000 days in Brazil (I WANT)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-11	Hospital Universitário da Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8rwyp5g	<NULL>	Healthy volunteers. Both genders. At least 18 years old. Be a Primary Health Care professional in the municipalities of selection. Be a support network for pregnant women, women who have recently given birth and/or mothers of 2-year-old children. Be pregnant, have recently given birth and/or the mother of a 2-year-old child	Primary Health Care professionals who were on vacation, on leave and/or away for any reason. Pregnant women, puerperal women and/or mothers of children up to two years old who refused to participate voluntarily	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-9jkkvbb	Effect of purple grape juice on performance and muscle recovery in male runners	Data analysis completed	Intervention	2023-07-26	<NULL>	<NULL>	7409	Effect of purple grape juice (Vitis labrusca) consumption on parameters related to sports performance and exercise-induced muscle damage in runners	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9jkkvbb	<NULL>	Male; age between 18 and 45 years; trained runners with a history of participating in competitions at least once a year; run at least 5 hours a week	Smokers; carriers of any diseases, infectious or inflammatory processes; history of recent musculoskeletal injuries; users (the last 30 days will be considered) of vitamin supplements, minerals, ergogenic aids (such as carnitine, arginine, citrulline, taurine, creatine and caffeine, nitrate, beta-alanine and sodium bicarbonate) or chronic use medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-6r9jw7c	Effects of detraining and retraining on the health of the elderly	Data analysis completed	Intervention	2024-10-08	<NULL>	<NULL>	7411	Physical Exercise for promoting the health of older women	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6r9jw7c	<NULL>	Be over 60 years old; woman; active; participate in the university extension project	Be under 60 years old; sedentary; not participate in the university extension project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-8rp76n4	Use of Virtual Reality to relieve anxiety and fear before medical consultation in Pediatric Oncology: a randomized clinical trial	Data analysis completed	Intervention	2024-10-11	<NULL>	<NULL>	7426	Evaluation of the usability of a Virtual Reality Tool in the distraction of children and adolescents with Cancer during venous puncture	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-01-01	Hospital de Amor Infantojuvenil de Barretos	Hospital de Amor Infantojuvenil de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-8rp76n4	<NULL>	Patients between 7 and 16 years old; both sexes; who had their first appointment scheduled on an outpatient basis	Patients with visual and/or hearing deficits; patients with sensitivity to light; children with clinical conditions of nausea or vomiting when visually stimulated or very exacerbated at the time; patients with external shunts that prevent the use of the tool; patients with tumors in the head and neck region that are obstructive; patient diagnosed with epilepsy; patient or companion with cognitive impairment clinically assessed by the research team (impediment to completing the questionnaires and using the tool); patients who express anticipatory conditional generalized anxiety or untreated panic attacks; patients with clinical diagnoses of mental changes without pharmacological treatment assessed as impediment by the researcher; patients with a clinical diagnosis of Organic Brain Syndrome due to neurotoxicity (already treated or with some impeding deficit); Furthermore, if the researcher, when inviting the patient to the research, noticed that he was in intense pain and in need of medication intervention, she excluded the patient from the research and referred him to the Outpatient Intercurrence Center so that he could receive medical intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-6wf5hpt	Effects of Mirror Therapy on motor function of the paretic upper limb in chronic stroke	Data analysis completed	Intervention	2024-10-15	<NULL>	<NULL>	7432	Effects of Mirror Therapy on the motor function of the paretic upper limb of individuals affected by Stroke in the chronic phase	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Centro Educacional de Lavras	Centro Educacional de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-6wf5hpt	<NULL>	Age 18 years or older; clinical diagnosis of unilateral ischemic or hemorrhagic stroke;at least six months post-stroke; presenting with upper limb hemiparesis; no severe spasticity in the paretic upper limb (Modified Ashworth Scale score less than 4); no significant cognitive impairments (Mini-Mental State Examination score of 24 or higher for those with formal education, and 14 or higher for illiterate individuals);individuals with no visual impairments that would hinder their ability to observe movements in the mirror	Participants who missed more than 30% of Mirror Therapy sessions were excluded; individuals already receiving physiotherapy for their paretic upper limb were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3ms5dgd	Effect of the Supported Self-Care technique on adequate follow-up of Warfarin treatment	Data analysis completed	Intervention	2024-10-19	<NULL>	<NULL>	7442	Effect of Supported Self-Care on adherence to oral anticoagulants	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3ms5dgd	<NULL>	Age 18 or older; both genders; Being treated with warfarin; Being under outpatient follow-up for blood clotting control; Presenting an unsatisfactory adherence score (&lt;6) on the Morisky Medication Adherence (MMAS-8); Having a landline or cell phone for teleconsultation; Presenting a satisfactory cognitive evaluation according to the application of the Mini-Cog© test	Participating in another study simultaneously; Pregnant women; Having any communication barriers that limit the implementation of the intervention and/or interviews. More than ten successive and unsuccessful attempts at telephone contact; Failure to show up for blood sample collection for INR assessment purposes for more than 2 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-487ggmz	Evaluation of two materials in maxillary sinus grafting	Data analysis completed	Intervention	2024-10-22	<NULL>	<NULL>	7450	Histomorphometric comparative analysis of two different bovine-derived biomaterials in human maxillary sinus augmentation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-20	Universidade do Grande Rio	Universidade do Grande Rio	https://ensaiosclinicos.gov.br/rg/RBR-487ggmz	<NULL>	Inclusion criteria consisted of volunteers with minimum of 18 years-old requiring reconstruction of the posterior maxillary bone height; with residual bone height in the maxillary sinus floor of less than 5 mm as determined by prior cone-beam computed tomography	Patients will be excluded if present with uncontrolled periodontal disease; uncontrolled systemic diseases; sinus pathologies; smoking habits; residual roots in the maxillary sinus; and those who had undergone head and neck radiation therapy for cancer treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-9gzqp3v	Effect of Probiotic Mixture Supplementation on Constipation	Data analysis completed	Intervention	2024-10-31	<NULL>	<NULL>	7470	Effect of Probiotic Mix Therapy on Intestinal Constipation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-19	Faculdade de Nutrição - Universidade Federal de Goiás	Faculdade de Nutrição - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9gzqp3v	<NULL>	Women; age between 20 and 59; self-reported stool types two to four on the Bristol Stool Scale; who had at least two of the criteria on the Rome IV Index	Women undergoing bariatric surgery; history of persistent diarrhea or inflammatory bowel disease; irritable bowel syndrome; vegetarian or on a diet; regular alcohol consumption (&gt; 7 drinks/week); smokers; moderate or vigorous exercise &gt; 3 h/week; use of antibiotics, laxatives, immunosuppressants, diuretics and antacids within one month before the start of the intervention; use of probiotic, prebiotic or symbiotic supplements; use of fermented foods during this same period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-557mbvy	Intervention with access information via cell phone to increase the use of the HPV vaccine in people living with HIV/AIDS	Data analysis completed	Intervention	2024-10-31	<NULL>	<NULL>	7472	Mobile device intervention to increase HPV vaccine coverage in people living with HIV/AIDS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-06	Centro de Pesquisas Gonçalo Moniz - FIOCRUZ/ BA	Centro de Pesquisas Gonçalo Moniz - FIOCRUZ/ BA	https://ensaiosclinicos.gov.br/rg/RBR-557mbvy	<NULL>	Women and men between the ages of 18–45 years; living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS); and who provided informed consent to participate	Women and men who had received any dose of human papillomavirus (HPV) vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-4m2qhhv	Immediate effect of Weight Training, Vascular Occlusion and Jumping on performance in the 50-meter freestyle	Data analysis completed	Intervention	2024-11-01	<NULL>	<NULL>	7475	Immediate effect of Strength Training, Blood Flow Restriction and Plyometrics on swimming&apos;s 50-meter sprint performance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Departamento de Educação Física - Universidade Federal do Rio Grande do Norte	Departamento de Educação Física - Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4m2qhhv	<NULL>	Participants aged between 14 and 40 years old; both genders; who had no musculoskeletal injuries; who provided a signed Free and Informed Consent Form (FICF); who practiced swimming at least three times a week	Participants who reported using any substance that could increase sports performance during the tests; who are at risk of pulmonary thromboembolism; venous thrombosis; varicose veins; heart failure; who have not been training regularly; who did not participate in any phase of the study or dropped out for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-368fdb3	Treatment of female pattern baldness using microneedling techniques: a scalp analysis	Data analysis completed	Intervention	2024-11-04	<NULL>	<NULL>	7478	Treatment of female pattern alopecia using microneedling techniques: clinical, dermatoscopic and  histopathological analysis of the scalp	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-30	Hospital das Clínicas da Universidade Federal do Paraná	Hospital das Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-368fdb3	<NULL>	Age greater than 18 years old and less than 65 years old; clinical and dermoscopic diagnosis of female pattern alopecia under regular treatment for at least 12 months with the same dosage of medications, and limited response to treatment	Clinical, dermoscopic or histological signs of scarring alopecia; non-compliance with any study procedures; triggers for telogen effluvium in the last three months before inclusion in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-3yrrhns	Virtual Reality Therapy for patients admitted to Intensive Care Units	Data analysis completed	Intervention	2024-11-04	<NULL>	<NULL>	7479	Comparison between three physiotherapeutic protocols in patients admitted to the Intensive Care Unit: Conventional Physiotherapy, Non-Immersive Virtual Reality Therapy and Combined Therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-14	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3yrrhns	<NULL>	Patients who had been hospitalized since the day before the start of the protocol; with hemodynamic stability; age between 18 and 60 years; both sexes; with preserved sensitivity and cognitive abilities	Patients belonging to the group of vulnerable people, such as: pregnant women, institutionalized or indigenous people; patients who received systemic corticosteroids or neuromuscular blockers for more than 5 days were not included due to neuromuscular weakness caused by the medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-38mm3wn	Study on the efficiency of removing blood from the drain after heart surgery to avoid blockages	Data analysis completed	Intervention	2024-11-08	<NULL>	<NULL>	7494	Scientific evidence of the efficacy of mediastinal drainage milking in postoperative cardiac surgery as prevention of hematic occlusion: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-22	Faculdade de Medicina da Universidade Federal do Amazonas	Faculdade de Medicina da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-38mm3wn	<NULL>	Patients over 18 years old; being in the immediate postoperative period of any cardiac surgery by Median Sternotomy with mediastinal drain inserted; both sexes	Patients with mediastinal drainage inserted after surgical re-approach for any cause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-74ffv8	Acute effect of different modalities of electric current therapy for the control of pain and temperature in people with Knee Osteoarthritis	Data analysis completed	Intervention	2018-10-25	<NULL>	<NULL>	7500	Immediate effects of different electrotherapy modalities in the control of pain and temperature of individuals with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade de Ceilândia da Universidade de Brasília	Fundação de Ensino e Pesquisa em Ciências da Saúde da Secretaria de Estado da Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-74ffv8	<NULL>	Aged 60 years or older; engage in a minimum of 45 minutes per week of accumulated physical activity at a moderate intensity level; report a pain intensity equal to or exceeding 4 cm on a 10-cm visual analogue scale	Individuals who had undergone physiotherapy in the previous 3 months; received knee injections in the previous 6 months; had medical constraints, such as cardiorespiratory, neurological, or rheumatological dysfunctions; had undergone prior hip, knee, or ankle surgery; had chronic conditions leading to knee pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-8hhw3s2	The effects of Auriculotherapy in the stress of physiotherapy students	Data analysis completed	Intervention	2024-11-14	<NULL>	<NULL>	7513	Early and late effects of Auricular Acupunture on students with Burnout Syndrome in the physiotherapy course at UFPR	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-19	Curso de Fisioterapia da Universidade Federal do Paraná	Setor de Ciências da Saúde da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8hhw3s2	<NULL>	Individuals between 18 and 25 years old; of both sexes; students actively enrolled in the Physiotheraphy course at the Universade Federal do Paraná	Lack of integrity of the ear; non-acceptance of voluntarily participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3tq63qk	Use of Radiofrequency Energy in the vulvovaginal region for the treatment of women with Urogenital symptoms present in Menopause and who have previously undergone radiotherapy	Data analysis completed	Intervention	2024-11-14	<NULL>	<NULL>	7514	Evaluation of the use of vulvovaginal Microablative Fractional Radiofrequency (MAFRF) in women with Genitourinary Syndrome of Menopause and previously submitted to pelvic radiotherapy and or brachytherapy	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2017-08-17	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tq63qk	<NULL>	Menopausal patients who had undergone pelvic radiotherapy or brachytherapy, complaining of menopausal urogenital syndrome; Pap smear test negative for neoplasia, within the routine deadline recommended by the Ministry of Health/INCA; without active genital hormone therapy	Use of estrogenic and or androgenic hormone therapy in the last sixty days; adverse anatomical conditions; users of pacemakers or internal defibrillators or any other active electrical implant; permanent implant in the treated area, such as polypropylene meshes; severe decompensated clinical conditions (such as cardiac dysfunctions; active systemic collagenoses; confirmed or presumed immunodeficiencies)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-104qgt7b	The offer of Yacon Syrup to overweight and obese women with Polycystic Ovary Syndrome and glycemic control	Data analysis completed	Intervention	2024-11-21	<NULL>	<NULL>	7529	Offering Yacon Syrup to women with Polycystic Ovary Syndrome, and overweight/obesity: impacts on postprandial glycemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-24	Centro de Saúde Escola da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Centro de Saúde Escola da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104qgt7b	<NULL>	Women; in reproductive age between 18 and 40 years; with Body Mass Index (BMI) indicating overweight, obesity I, and 2 (greater than or equal to 25 kg/m²  or lower than or equal to 39,9 kg/m²)	Women who are smokers; alcoholics; pregnant or breastfeeding; volunteers diagnosed with kidney, liver, or thyroid diseases, diabetes mellitus, Cushing syndrome, ovarian insufficiency, presence of ovarian or uterine tumors, congenital adrenal hyperplasia; or those who did not comply with all the protocols established for the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-4fc33kz	Determination of the glycemic response to the consumption of specialized oral nutritional supplement and specialized high-protein enteral formula for glycemic control	Data analysis completed	Intervention	2024-11-28	<NULL>	<NULL>	7544	Glycemic response of individuals to the consumption of enteral nutrition formula	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-06	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fc33kz	<NULL>	Healthy volunteers; aged between 18 and 45 years; both genders; with good health conditions according to a report of absence of diabetes, renal and gastrointestinal diseases and hyperthyroidism; having a Body Mass Index (BMI) within the normal range of 18.5 to 24.9 kg/m²; with normal glucose tolerance (between 70 and 99 mg/100 mL in the morning, after fasting for 10 hours) and maximum postprandial blood glucose of 140 mg/100 mL and close to fasting after 2 hours	Volunteers using any type of medication that could affect digestion and absorption of food (antibiotics, medications for diarrhea and constipation) during the study period; hormone therapy; presence of pregnancy or breastfeeding; family history of diabetes; significant glycemic variations in the glycemic response test to the reference food	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-59j57vj	Effect of Magnesium Chloride supplementation on Depression	Data analysis completed	Intervention	2024-12-04	<NULL>	<NULL>	7567	Effect of magnesium chloride supplementation on brain electrical activity in individuals with depression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-59j57vj	<NULL>	Volunteers diagnosed with depression, both sexes, between 18 and 60 years old, both sexes, with stable use of antidepressants and no change in the treatment plan in the last 2 months, with weight within the limit of variation of 15% of the weight considered normal for men and women.	Individuals with associated psychiatric clinical conditions or other clinically unstable pathologies, alcohol and/or illicit substance abuse, gastrointestinal disease, pregnant or trying to get pregnant and individuals with surgery planned within the next 6 months were excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-438qrmr	Footcore Exercises on variables of running	Data analysis completed	Intervention	2024-12-06	<NULL>	<NULL>	7578	The influence of Footcore Exercises on the biomechanical variables of running, stability and functionality of lower limbs in street runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade de Caxias do Sul	Universidade de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-438qrmr	<NULL>	Long-distance runners of both sexes; aged 18 to 45 years; trained running on the street regularly at least three times a week, totaling between 20 km to 100 km per week; had been practicing the modality for at least one year; agreed to participate in the study voluntarily and presented a signed Informed Consent Form	Had any cardiorespiratory, neuromuscular, or metabolic disease preventing participation; had cognitive or motor deficits and musculoskeletal diseases; presented the following absolute contraindications: soft tissue healing; severe pain; severe joint effusion; acute injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-4w622cw	Physical exercise program for elderly people with physical fragility	Data analysis completed	Intervention	2024-12-14	<NULL>	<NULL>	7591	Geti: biopsychosocial and environmental study of individuals in third age	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Fundação Universidade do Estado de Santa Catarina	Fundação Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4w622cw	<NULL>	Be 80 years of age or older; both sexes; preserved cognitive function and physical frailty	Those who present a contraindication to the practice of physical activity or any other type of activity will be excluded. Other activity proposed by GETI, have a declared or confirmed physical disability and sequelae of pathologies neurological	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9jv6nh4	Experimental dentifrice based on Red Propolis on orthodontic patients	Data analysis completed	Intervention	2024-12-16	<NULL>	<NULL>	7594	Analysis of Volatile Sulfur Compounds (VSC) pre and post therapy with Red Propolis toothpaste. Comparative periodontal and microbiological evaluation in patients using self-ligating orthodontic appliances and patients not undergoing orthodontic treatment	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Centro Universitário Hermínio Ometto	Centro Universitário Hermínio Ometto	https://ensaiosclinicos.gov.br/rg/RBR-9jv6nh4	<NULL>	Patients had good systemic health; age between 14 and 30 years old; both sexes	Use of antibiotic therapy in the last six months; use of anti-inflammatories in the last three months; smoking; pregnancy; fixed prosthesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-8w7d8np	The impact of math tasks on volleyball players&apos; performance: a randomized crossover study	Data analysis completed	Intervention	2025-01-02	<NULL>	<NULL>	7626	Effect of Math-related cognitive activities on Volleyball performance: a randomized crossover study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8w7d8np	<NULL>	Train volleyball for at least two years; compete at the school level; be between 12 and 17 years old; female	Withdraw from the research; absence on one of the data collection days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-55gksmb	The effect of mental fatigue on cognitive and physical aspects in young athletes and non-athletes	Data analysis completed	Intervention	2025-01-02	<NULL>	<NULL>	7627	The effect of mental fatigue on cognitive and physical aspects in young athletes and non-athletes	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-02-27	Departamento de Educação Física - Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-55gksmb	<NULL>	The inclusion criteria that will be adopted are: 1) to practice a systematized team sport at least twice a week with a previous history of at least 6 months; 2) to be male; 3) to be between the ages of 13 and 16; 4) to present the free and informed consent form (TCLE) and the free and informed assent form (TALE); 5) to have no physical limitations that would prevent the physical test from being carried out and no cognitive limitations that would prevent the psychological tests from being carried out cleanly.	The inclusion criteria that will be adopted are: 1) to practice a systematized team sport at least twice a week with a previous history of at least 6 months; 2) to be male; 3) to be between the ages of 13 and 16; 4) to present the free and informed consent form (TCLE) and the free and informed assent form (TALE); 5) to have no physical limitations that would prevent the physical test from being carried out and no cognitive limitations that would prevent the psychological tests from being carried out cleanly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-54wxgxv	The effect of a new program to improve the general and oral health of students at a municipal school in Bauru, São Paulo, Brazil	Data analysis completed	Intervention	2025-01-06	<NULL>	<NULL>	7636	Effectiveness of a new program to improve the general and oral health of schoolchildren in Bauru, São Paulo, Brazil	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-54wxgxv	<NULL>	Schoolchildren aged 6-9 years; feminine and masculine gender; children with cooperative behavior and in good physical and medical health; children who presented a signed consent form; the presence of first permanent molars without gingival tissue covering all the occlusal surface; and permanent first molars that present an occlusal surface of pits and fissures with a carious lesion in the enamel or with a high-caries-risk (presence of a tooth with a carious lesion, lost or restored, which is not a developmental defect of the enamel)	Children with orthodontic braces; paranormal occlusion; severe bruxism; allergy to resinous materials or any other material used in the study; and poor behavior	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-3nvq79h	Effects of Guarana on physical performance: a clinical study on anaerobic fitness	Data analysis completed	Intervention	2025-01-06	<NULL>	<NULL>	7637	Effects of Guarana (Paullinia cupana) supplementation on Heart Rate Variability and Anaerobic Fitness: a randomized, crossover, placebo-controlled, triple-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3nvq79h	<NULL>	Healthy and physically active men; age between 18 and 30 years; non-smokers; no history of cardiovascular or musculoskeletal diseases; not using any medication or ergogenic substances	Individuals who do not meet the inclusion criteria; are unable to perform the jump protocol or withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-10yj9xdv	Rehabilitation of shoulder dysfunctions using the Pilates method in patients with head and neck cancer undergoing neck dissection	Data analysis completed	Intervention	2025-01-07	<NULL>	<NULL>	7644	Rehabilitation of shoulder dysfunctions using the Pilates method in patients with head and neck cancer undergoing neck dissection with preservation of the accessory nerve: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-31	Fundação Cristiano Varella	Unifaminas	https://ensaiosclinicos.gov.br/rg/RBR-10yj9xdv	<NULL>	Patients of both sexes; over 18 years old; with a primary diagnosis of head and neck cancer; who underwent neck dissection with preservation of the accessory nerve; whether or not they have undergone radiotherapy and/or chemotherapy treatment; who have limited range of motion of the shoulder on the surgery side ranging from 50° to 149° for flexion and abduction movements; that are in the acute phase, that is, evaluated within a maximum period of up to 45 days from the date of surgery	Patients undergoing neck dissection where there is a need to perform complete resection of the accessory nerve; who have had previous surgery and/or radiotherapy for head and neck cancer; with shoulder dysfunction already established before the surgical procedure; who have received any physiotherapeutic care with the aim of restoring range of movement; who have a range of motion limited to less than or equal to 49° for shoulder flexion and abduction movements or greater than 149°; who have cognitive impairment or any other impairment that prevents them from performing and understanding the proposed exercises; who underwent bilateral surgery and as a result have a range of movement for flexion and abduction of less than 150° in both upper limbs; those who refused to participate in the study; those who refused to sign the Free and Informed Consent Form after being informed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-6bcnbpq	Impact of the use of Flebon in the treatment of patients with Lipedema	Data analysis completed	Intervention	2025-01-10	<NULL>	<NULL>	7652	Impact of the use of Pycnogenol in the treatment of patients with Lipedema	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2024-02-23	B2 Medicos Associados	Farmoquimica	https://ensaiosclinicos.gov.br/rg/RBR-6bcnbpq	<NULL>	Women between 18-40 yeras old;with lipedema	Pregnant women;patients usig anorexigens;patients using anabolic medicines;patients on restrictive diets;patients with a proven adverse reaction to Pycnogenol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-3bgs2m2	Comparison between two Threads for Facial Suspension through the temple	Data analysis completed	Observational	2025-01-21	<NULL>	<NULL>	7671	Comparison between two Suture Threads in Temporal Endoscopic Facial Suspension	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-20	Universidade Palista - UNIP	Universidade Palista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-3bgs2m2	<NULL>	Women. Age 49 to 69 years. Not have performed any aesthetic procedure involving the use of botulinum toxin, injectable fillers of any nature and facial threads and/or sutures in the last 48 months. The result of the FACE-Q Questionnaire - Satisfaction with Facial Appearance should be a final value between 10 and 20 points. Have a medical release form. Absence of systemic, uncontrolled comorbidities. Ability to join the visiting scheme. Commit not to receive any other aesthetic procedure on the face during the study period (18 months)	Indication of rehabilitative dental treatment. Underlying disease or clinical condition that impairs the sequence of study procedures. Have some neuropathic disease. Have bruxism or clenching. Being pregnant. Allergy to any medication used. History of an eating disorder or any other condition and/or disorder related to image or physical appearance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-10mdc4h7	Effects of taurine consumption on the physical performance of professional soccer players	Data analysis completed	Intervention	2025-01-23	<NULL>	<NULL>	7678	Effects of acute Taurine consumption on physical performance parameters in professional soccer athletes: a triple-blind, randomized, crossover clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-23	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10mdc4h7	<NULL>	To be a football (soccer) athlete; participate in the Under-20 category (ages 17 to 20); be involved in football competitions; have at least two years of formal and systematic experience in the sport prior to the start of the study	Presence of bone and/or muscle injury; history of recent musculoskeletal injuries; use of anti-inflammatory medication; use of taurine or caffeine-based supplements 24 hours before the protocols; presence of any disease in the central nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-5q2w7zt	Evaluation of Laser Snoring Treatment	Data analysis completed	Intervention	2023-01-13	<NULL>	<NULL>	7687	Clinical Evaluation of the Use of Er:YAG Laser in Snoring Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-28	Faculdade de Odontologia da Universidade de São Paulo	Instituto de Pesquisas Energéticas e Nucleares - IPEN	https://ensaiosclinicos.gov.br/rg/RBR-5q2w7zt	<NULL>	Patients who present a clinical picture compatible with primary snoring; mild or moderate obstructive sleep apnea with polysomnography (of any type); age group from 25 to 65 years; both sexes and regardless of color or social class; agreement and signing the free informed consent term	Have significant physical obstruction of the nostrils and/or throat observed by the physician with strict indication of surgery and those with laryngeal obstruction; having previously performed surgery in the oropharynx region; patients using more than two antihypertensive drugs or with a previous diagnosis of heart problems; patients using photosensitive medication; presence of lesion in the oropharynx; history of alcohol and/or drug abuse; smoking patients; patients with untreated neurological or psychiatric disorders; patients with craniofacial malformations; pregnant or lactating patients; patients with a BMI above 40kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4jwm3zw	Intervention program with working memory and reading for students with learning difficulties: development and pilot study	Data analysis completed	Intervention	2025-01-29	<NULL>	<NULL>	7693	Elaboration and verification of the therapeutic efficacy of an intervention program with the phonological and visuospatial working memory for schoolchildren with learning difficulties	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-03	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-4jwm3zw	<NULL>	Voluntary consent by signing the Free and Informed Consent Form; Female and male schoolchildren aged between 9 years and 10 years and 11 months; Presence of learning difficulties confirmed by standardised assessment procedures (lower performance of schoolchildren in tests of metalinguistic skills and reading - PROHMELE).	Previous participation in speech therapy, pedagogical or psycho-pedagogical intervention programs; Presence of genetic syndromes, intellectual disability and attention deficit hyperactivity disorder, described in school records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-8qkmmb4	Evaluation of Motor Learning and Its Relationship with Quality of Life, Participation, and Functionality in Adolescents with Cerebral Palsy	Data analysis completed	Observational	2025-01-29	<NULL>	<NULL>	7695	Assessment of the Motor Learning Process Using a Mobile Device and Its Relationship with Quality of Life, Participation, and Functionality in Adolescents with Cerebral Palsy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-10	Universidade Federal de Alfenas -UNIFAL	Universidade Federal de Alfenas -UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-8qkmmb4	<NULL>	Age between 12 and 17 years. Both sexes. Classified at levels I, II, III, or IV of the Gross Motor Function Classification System. At levels I, II, or III of the Manual Ability Classification System. Participants with expected performance for their educational level, as assessed by the Nonverbal General Intelligence Test BETA III, in the subtests Matrix Reasoning – Nonverbal Intelligence and Processing Speed. Those scoring above the 10th percentile and with basic knowledge of numbers from 1 to 30 as a supplementary criterion. Adolescents regularly enrolled at Dr. José Vargas de Souza Municipal School.	Those classified at level V of the Gross Motor Function Classification System, at levels IV and V of the Manual Ability Classification System. Those with severe cognitive impairment that hindered the execution of activities. Adolescents with any evident or diagnosed sensory, motor, or cognitive deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4x9j9hq	Effect of Caffeine on respiratory muscle in premature newborns	Data analysis completed	Observational	2025-01-30	<NULL>	<NULL>	7699	Effect of Caffeine Citrate on diaphragmatic electrical activity in pre-term newborns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-07-19	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-4x9j9hq	<NULL>	Newborns; of both genders; preterm newborns with gestational age equal to or less than 28 weeks; newborns between 28 and 32 weeks of gestational age under  invasive or non-invasive ventilatory support; newborns with clinical diagnosis of apnea with gestacional age less than 37 weeks	Patients with major congenital malformations; anomalies of the upper digestive tract; primary neurological or drug-related abnormalities; newborns under high-frequency mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-2why5rd	Effects of laser therapy associated or not with mirror therapy on the functionality of the upper limbs and cognition of individuals who have suffered a Stroke	Data analysis completed	Intervention	2025-01-30	<NULL>	<NULL>	7700	Effects of Transcranial Laser Therapy associated or not with mirror therapy on the functionality of upper limbs and cognition in individuals affected by Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2why5rd	<NULL>	Both sexes; older than 18 years; clinical diagnosis of stroke in the chronic phase (more than six months); up to grade 2 on the Ashworth scale; ability to respond to simple commands using the least affected limb in pre-defined tasks; signed the Free and Informed Consent Form	Not having resources to travel to the study location; diagnosis of Transient Ischemic Attack; plegia; history of seizures and/or use of medication to control them; diagnosis of other associated neurological diseases; pregnancy; do not present motor sequelae in the upper limbs resulting from the stroke	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-9cdr2yx	Telerehabilitation on patients undergoing Surgical Treatment for Breast Cancer	Data analysis completed	Intervention	2025-02-05	<NULL>	<NULL>	7709	Analysis of the influence of Telerehabilitation on the Functional Capacity and Pulmonary Function of patients undergoing Surgical Treatment for Breast Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-9cdr2yx	<NULL>	women over 18; breast cancer diagnosis; Internet access; undergoing surgical treatment for breast cancer; agree to participate in the research	women with some myoskeletal, orthopedic, neurological dysfunction; cognitive and/or communication impairment; volunteers who refuse to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-5g9j7k	Comparison between dry land and aquatic physical therapy effects on physical activity and other clinical variables in asthmatic children	Data analysis completed	Intervention	2020-11-05	<NULL>	<NULL>	7715	Comparison between aquatic and dry land physical training on exercise capacity and other clinical outcomes in asthmatic children: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-09	Universidade Norte do Paraná - UNOPAR	Universidade Estadual de Londrina - UEL	https://ensaiosclinicos.gov.br/rg/RBR-5g9j7k	<NULL>	Asthmatic children between 7 and 11 years old; both genders; clinically medicated and stable; recruited through active search in schools; able to perform all of the study procedures	Presence of comorbidities that could prevent performance assessment and intervention procedures; history hospitalization and/or pneumonia 3 months before and during the study; have previous participation in any complementary pulmonary rehabilitation treatment in the last 6 months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-3p6t9pm	Ultrasonographic effect of Shoulder and Surgical Table Rotation maneuvers on the lumbar and thoracic vertebral spaces of Elderly	Data analysis completed	Intervention	2024-10-21	<NULL>	<NULL>	7729	Impact of Shoulder Rotation and Table Tilt Maneuvers on the lumbar and thoracic acoustic window of elderly individuals	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-19	Universidade Federal de Pernambuco	Hospital da Restauração	https://ensaiosclinicos.gov.br/rg/RBR-3p6t9pm	<NULL>	Both genders; 65 years or older; agree to participate and sign the free and informed consent form	Allergy to ultrasound gel; patients who are unable to perform adequate positioning to capture images; low quality image or with questionable measurement of the posterior longitudinal ligament; who have a history of trauma, surgery or abnormality (congenital or acquired) of the spine or shoulders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-6fxhwqw	Evaluation of the use of membranes obtained from blood centrifugation for gingival retraction repair surgeries in smoker patients	Data analysis completed	Intervention	2025-02-11	<NULL>	<NULL>	7732	Evaluation of the use of Platelet Rich Fibrin for root coverage of Cairo Type I gingival recession in smoker patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-09	UNIOESTE - Universidade Estadual do Oeste do Paraná	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6fxhwqw	<NULL>	Smoking patients; with Cairo Type I gingival recession; bilateral; aged between 20 and 50 years; both genders; without comorbidities seeking treatment at the Unioeste Dentistry Clinic	Exclusion criteria include; individuals who do not meet the criteria of cigarette consumption &gt; 10 cigarettes/day; positive history of antibiotic therapy in the last six months and anti-inflammatories; steroids or non-steroids; in the three months preceding the study; positive history of pregnancy; positive history of any systemic problem that contraindicates the surgical procedure; endodontic treatment or pulp pathology in the involved tooth; pathogenic occlusal interferences and previous surgery at the site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-10t8m6m2	High versus low dose Vitamin D3 in severe Systemic Lupus Erythematosus on Pulse Methylprednisolone: a randomized, double blind, placebo controlled clinical trial	Data analysis completed	Intervention	2025-02-12	<NULL>	<NULL>	7739	Assessment of Vitamin D supplementation in patients with Systemic Lupus Erythematosus admitted to the rheumatology ward	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10t8m6m2	<NULL>	Patients with Systemic Lupus Erythematosus (according to the classification criteria defined by the Systemic Lupus International Collaborating Clinics of 2012). Age greater than or equal to 18 years. High disease activity (SLEDAI-2K greater than 11) requiring hospitalization for administration of intravenous pulse therapy with methylprednisolone. Patients with Systemic Lupus Erythematosus and concomitant infection were also eligible, provided they presented active disease after clinical evaluation. Both sexes	Concomitant diagnosis of another autoimmune disease; Body Mass Index - BMI greater than or equal to 35 kg/m2; severe renal failure - estimated glomerular filtration rate below 30 ml/min; history of nephrolithiasis, hypercalciuria (greater than or equal to 4 mg/kg/24 hours); hypercalcemia (total calcium corrected by albumin greater than 10.2 mg/dl); intestinal malabsorption; chronic liver disease; pregnancy, lactation; refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-7bb6mhc	Effect of Vaginal Laser in menopause: a comparative study on Genitourinary Symptoms	Data analysis completed	Intervention	2025-02-14	<NULL>	<NULL>	7750	Genitourinary Syndrome of menopause in patients treated with Vaginal CO2 Laser: a randomized clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7bb6mhc	<NULL>	Healthy postmenopausal women (at least 12 months since their last menstrual period, or with bilateral oophorectomy, or hysterectomized with follicle-stimulating hormone higher than 40 U/L; estradiol lower than 25 pg/mL); negative oncotic colpocytology within the last year; who agree to participate in the study and sign the informed consent form (ICF)	Active or recent (&lt;15 days) vaginal lesions; use of hormone replacement therapy in the last 6 months; untreated genitourinary tract infections; abnormal uterine bleeding; history of photosensitivity disorder or use of photosensitizing drugs; grade II-III genital prolapse (according to the Pelvic Organ Prolapse Quantification system, POP-Q); bacterial or viral vaginal infection (HPV, Herpes); immunosuppression; chronic corticosteroid use; scleroderma; extensive prior radiotherapy; burns in the area; collagen disorders; pregnancy and breastfeeding; genital neoplasia; anticoagulant therapy; patients with sling/mesh; uncontrolled diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-8zmxfnp	Modification of Hand Strength induced by opposite Wrist Strength and Acupuncture	Data analysis completed	Intervention	2023-01-19	<NULL>	<NULL>	7762	Modification of Palmar Grip Strength induced by Overflow of non-homologous muscles and Acupuncture at points HT3 (ShaoHai) and HT7 (ShenMen)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-30	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8zmxfnp	<NULL>	Healthy volunteers; both genders; age between 18 and 30 years; right motor preference	Diagnosis of orthopedic pathologies; pain in upper limbs; fear of needles; pregnant women; women with delay in menstrual cycle longer than 28 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6bn7y6z	Evaluation of Colchicine Peeling for the treatment of premalignant skin lesions	Data analysis completed	Intervention	2025-02-21	<NULL>	<NULL>	7776	Colchicine peeling versus placebo for actinic keratoses	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-08-16	Sociedade Brasileira de Dermatologia Regional São Paulo - FUNADERSP	Sociedade Brasileira de Dermatologia Regional São Paulo - FUNADERSP	https://ensaiosclinicos.gov.br/rg/RBR-6bn7y6z	<NULL>	Sign the Free and Informed Consent Form; Age over 18 years of age for both sexes; Present at least three and no more than ten lesions clinically compatible with actinic keratosis on each forearm, bilaterally	Less than three or more than ten lesions on each forearm; Use of any specific treatment for AKs and/or cutaneous cancerization in the last 6 months; Selected treatment area with an atypical clinical appearance or other extensive dermatoses on the forearms; Current and previous clinical diagnosis or evidence of any medical comorbidity that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; Present hypersensitivity or allergy to any of the substances under study; Patients using any systemic or topical immunosuppressive substance, oral retinoid, in addition to other local treatments (e.g. corticosteroids, anti-inflammatories, retinoids); Immunocompromised individuals; Coagulation disorders; Suspected or confirmed pregnancy; Women who are breastfeeding; Refusal to undergo dermatological ultrasound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-7nh566t	Effects of Omega-3 and Aspirin, with or without Antibiotics, in the treatment of Severe Gum Disease	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7786	Clinical and microbiological effects of Immune modulation, with or without Systemic Antibiotics, in the treatment of Periodontitis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Guarulhos	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-7nh566t	<NULL>	Severe periodontitis; at least 15 teeth; aged over 29 years; males and females	Smokers; former smokers for at least 5 years; pregnant or lactating women; history of periodontal treatment in last 6 months; continuous use of oral antiseptics; use of systemic antibiotics, corticosteroids, non-steroidal anti-inflammatory drugs, immunosuppressants, estrogen, and estrogen receptor modulators; medicines that may influence bone metabolism, such as alendronate, calcitonin, and others, in the last 6 months; continuous use of medications; a systemic disease that may alter the response to periodontal or requiring prophylactic medication for dental treatment; report of allergy to metronidazole or amoxicillin, aspirin or fish and seafood; use of orthodontic appliances; prostheses; blood dyscrasias, gastritis or gastric ulcer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-5dt62k4	Serious game associated with Cycling for the treatment of Stroke patients	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7788	Serious Game associated with Cycle Ergometry for rehabilitation of hemiparetic patients due to Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Faculdade Guilherme Guimbala	Faculdade Guilherme Guimbala	https://ensaiosclinicos.gov.br/rg/RBR-5dt62k4	<NULL>	Hemiparetic stroke patients volunteers; 18 years or older; clinically stable and in the chronic phase of the disease; able to walk independently, the use of a walking aid device was permitted; signing the Free and Informed Consent Form (FICF), expressing interest in participating in the project	Patients with hemiparesis resulting from pathologies other than stroke, as well as hemiplegic patients; patients who do not have lower limb impairment; patients who have bilateral motor impairment, which prevents characterization as hemiparetic; patients with severe visual and/or auditory impairment; uncooperative patients and/or with cognitive deficit (assessed with the Mini Mental State Examination); patients who are undergoing any other type of rehabilitation for the lower limbs or for the respiratory system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8hhwzbj	The Effect of Physical Exercise on Long COVID	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7790	Effect of Different Types of Physical Exercise on the Rehabilitation of Long COVID	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Instituto Federal de Educação, Ciência e Tecnologia de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8hhwzbj	<NULL>	Physically inactive for at least 3 months. aged 18 years or older. A positive COVID-19 test conducted at least 6 months ago. Both sexes	Younger than 18 years old. Active smoker. Never had COVID-19	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-6zhmt6r	Uterine removal with vaginal suspension using Splentis for women with uterine prolapse	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7791	Evaluation of the efficacy and safety of Prophylactic Vaginal Dome Fixation using the Splentis™ device during Vaginal Hysterectomy in patients with Uterine Prolapse	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-06-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-6zhmt6r	<NULL>	Women at least 18 years old; with uterine prolapse grades III or IV; women wanting hysterectomy	History of thrombosis or thromboembolic disorders; chronic kidney or liver disease; cerebrovascular accident or transient ischemic attack; endometrial hyperplasia; rheumatological diseases; low- or high-grade squamous intraepithelial lesions of the cervix, vagina, or vulva; untreated genitourinary infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8gb3sfj	Effect of Rapid and Repeated Practice compared to Traditional Simulation on learning Cardiopulmonary Resuscitation by nursing students	Data analysis completed	Intervention	2025-02-26	<NULL>	<NULL>	7803	Effectiveness of simulation strategies in theoretical-practical learning about Cardiopulmonary Resuscitation for nursing students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-14	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8gb3sfj	<NULL>	Being regularly enrolled in the first year of the Bachelor of Nursing course at the School of Nursing at the University of São Paulo (EEUSP); be available to participate in the three stages of the study, the first being distance learning and the others in person; be at least 18 years old; both sexes	Having physical limitations that would prevent participation in the simulated practical activity; having participated in a Basic Life Support (BLS) course within the past two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8xz3t35	How macronutrients affect Skin Temperature in para-athletes: a crossover study with Infrared Thermography	Data analysis completed	Intervention	2025-03-10	<NULL>	<NULL>	7827	Effect of the influence of meals with different macronutrient compositions on the thermographic response at rest and post-exertion in paralympic athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Escola de Educação Física da Universidade Federal de Minas Gerais	Escola de Educação Física da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8xz3t35	<NULL>	Athletes from the competitive teams of the Paralympic sports of para-taekwondo, powerlifting, swimming, and athletics at the Brazilian Paralympic Reference Center of Universidade Federal de Minas Gerais; individuals aged between 18 and 50 years; athletes who have participated in state, national, or international competitions in the past year; and those who have an eligible impairment to compete in the mentioned Paralympic sports; both sexes	Individuals under 18 years of age or over 50 years; those who have not participated in state, national, or international competitions in the past year; athletes with food allergies or intolerances that prevent participation in the proposed nutritional interventions; individuals with inflammatory processes or muscle injuries in the last two months; participants with a history of severe and disabling injuries that prevent them from regular training; and athletes who do not have an eligible impairment to compete in Paralympic sports	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-44cvfnq	Effects of a meditation and mindfulness program on the mental health of medical students	Data analysis completed	Intervention	2025-02-26	<NULL>	<NULL>	7836	Impact of a Mindfulness-Based Stress Reduction Program on medical students: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-29	Universidade do Grande Rio Professor José de Souza Herdy	Escola de Medicina e Cirurgia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO)	https://ensaiosclinicos.gov.br/rg/RBR-44cvfnq	<NULL>	Medical students from Universidade do Grande Rio Professor José de Souza Herdy (UNIGRANRIO); both genders; own a smartphone with WhatsApp® and internet access; aged 18 years or older; provide written informed consent	Previous diagnosis of decompensated psychiatric disorders; inability to attend in-person sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-7pghdmt	Postprandial effect of whole or ground flaxseed in people with type 2 Diabetes	Data analysis completed	Intervention	2025-03-24	<NULL>	<NULL>	7860	Acute effect of consumption of ground or whole flaxseed on blood glucose levels in people with type 2 diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Franciscana	Universidade Franciscana	https://ensaiosclinicos.gov.br/rg/RBR-7pghdmt	<NULL>	People diagnosed with type 2 Diabetes; both genders; adults aged 18 and over and elderly people without risk of dysphagia; who eats breakfast regularly (4 days a week, with an intake of 100 kcal within two hours of waking up); who like and commit to consuming the foods proposed in the study; and who have time available for the days planned for the research	Individuals diagnosed with another type of Diabetes mellitus; use of exogenous insulin; with decompensated Diabetes (capillary blood glucose 180 mg/dl on the day of the test); pregnant and breastfeeding women; depressive; smokers; alcoholics; with gastrointestinal disease; neurological; history of alcohol or drug abuse; that report the last bowel frequency according to the Bristol scale 1, 2, 5, 6 and 7; and allergic to the foods used in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-3hsj6g6	Effects of Tamsulosin on semen parameters	Data analysis completed	Intervention	2021-09-20	<NULL>	<NULL>	7868	Effects of Tamsulosin on ejaculation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-20	Faculdade de Medicina do ABC	Instituto Ideia Fértil de Saúde Reprodutiva	https://ensaiosclinicos.gov.br/rg/RBR-3hsj6g6	<NULL>	Men aged 18 to 45 years; with the ability to perform sperm collection; who accept to participate as volunteers in the research	History of neurological changes even if treated; history of liver disease; history of kidney disease; history of use of exogenous testosterone or anabolic or androgen; history of diabetes mellitus; history of pelvic or genital surgery; concomitant use of specific medications (ketoconazole  erythromycin   other alpha blockers  warfarin and diclofenac); inability to collect sperm by masturbation; sperm changed according to WHO standards; negative to sign a free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-98yskk7	Effect of prior knowledge about a Caries-arresting product on caregivers&apos; opinion and acceptance regarding the appearance of children&apos;s primary teeth after use	Data analysis completed	Intervention	2025-04-02	<NULL>	<NULL>	7877	Influence of prior knowledge about a substance that arrests Caries on caregivers&apos; acceptance and impression regarding the appearance of its use on children&apos;s primary teeth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-98yskk7	<NULL>	Guardians and caregivers of children aged between 1 and 5 years; who are treated at the Clinic for Babies and Children in Early Childhood of the School of Dentistry of the Federal University of Rio de Janeiro; both sexes; who agree to participate in the study	Guardians and caregivers of children involved in clinical studies in which silver diamine fluoride was one of the investigated interventions; who had already been treated with silver diamine fluoride; those with visual impairments; who do not own smartphones	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-62f6qwh	The effects os the Dental Treatment for the patients with Head and Neck Cancer	Data analysis completed	Intervention	2022-10-03	<NULL>	<NULL>	7892	The Odontological Treatment on the Head and Neck Cancer patient	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-62f6qwh	<NULL>	Presence of tumors in the oral cavity that needed radiotherapy, with or without chemotherapy; age higher than 18 years old; and presence of at least 6 natural teeth, excluding third molars	Patients previously submitted to radiotherapy or chemotherapy; patients on non-oral feeding ways; patients using antiresorptive drugs; and patients that received dental treatment in the past 6 months before the first observational period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-7wt6hzm	Evaluation of Medical and Nutritional Treatment of Obesity through Online Care compared to In-Person Care in patients using Brazil&apos;s Public Health System	Data analysis completed	Intervention	2025-04-07	<NULL>	<NULL>	7899	Evaluation of Medical and Nutritional Treatment of Obesity through Telehealth compared to Conventional Treatment in a sample of patients of Brazil&apos;s Public Health System	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-7wt6hzm	<NULL>	Patients who are already being monitored at the Obesity Outpatient Clinic of the Federal University of São Paulo - UNIFESP (not treatment-naïve). Patients who have already been seen by a doctor in the last 6 months or less at this clinic. Men or women. Over 18 years of age. Agree to and sign a Free and Informed Consent Form (FICF). Agree to attend remotely. Have access to the internet and the possibility of having their blood pressure and weight measured before the remote consultation	Presence of diseases that cause difficulties in understanding and reasoning that indicate cognitive deficits (e.g. intellectual disability, senile dementia, neurological and genetic syndromes, limiting heart diseases, autistic spectrum disorder and psychotic disorders). Presence of Bulimia Nervosa Eating Disorder. Being pregnant or breastfeeding or planning a pregnancy (female patients). History of cancer in the last 5 years. Obesity of secondary cause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-6nzzhqk	Assessment of oxidative stress, damage to the membrane lining the cells of blood vessels, phase angle and clinical evolution in Heart Infarction	Data analysis completed	Observational	2025-04-15	<NULL>	<NULL>	7923	Evaluation of oxidative stress, endothelial glycocalyx injury, phase angle and clinical outcome in Acute Myocardial Infarction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-24	Unidade de Emergência do Hospital das Clínicas de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)	https://ensaiosclinicos.gov.br/rg/RBR-6nzzhqk	<NULL>	Patients diagnosed with acute myocardial infarction with ST segment elevation; male and female; of different races; aged 18 years or older within 72 hours of hospital admission	Patients with diagnosis of renal or hepatic disease; cancer; age over 80 years; use of external orthopedic or cardiac devices; mechanical ventilation; pregnancy; cardiorespiratory arrest or cardiogenic shock at admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-67qxnt9	Photobiomodulation in the prevention of induced Trissum by head and neck Radiotherapy	Data analysis completed	Intervention	2025-04-16	<NULL>	<NULL>	7925	Influence of Photobiomodulation in the prevention of induced Trissum by head and neck Radiotherapy: triple blind clinical test, randomized and controlled placebo	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2022-07-13	Instituto do Câncer do Ceará	Instituto do Câncer do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-67qxnt9	<NULL>	Patients over 18 years of age will be included; both sexes; with head and neck cancer in the nasopharynx, maxillary sinuses, oropharynx, mouth and salivary glands; stages I, II, III or IV in which head and neck radiotherapy has been indicated	Patients who underwent previous surgery for tumor resection and/or neck dissection, patients Patients who have undergone previous tumor resection and/or cervical dissection surgery will be excluded; patients with tumor recurrence or recurrence; previous history of head and neck radiotherapy; patients whose radiotherapy dose is less than 40G; patients who withdraw from treatment or the study; who required a change in the therapeutic protocol; who develop extreme toxicity or evolve to death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7qtvbh3	Study of the effects of Biperiden drug on reducing the desire to quit smoking	Data analysis completed	Intervention	2025-04-17	<NULL>	<NULL>	7934	Study of the acute effects of Biperiden on nicotine cravings: double-blind, placebo-controlled study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-10-20	Escola Paulista de Medicina	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qtvbh3	<NULL>	Patients with nicotine use disorder, according to DSM-5 criteria; who have intense compulsion, according to the Questionnaire of Smoking Urges-Brief (43 or more points); aged between 18 and 60 years; male and literate (with the ability to write and read Portuguese)	Present other psychiatric disorders (serious such as schizophrenia and bipolar mood disorder); severe disorder criteria when using other drugs or severe cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-3xqdph2	Respiratory muscle training combined with physiotherapy in hemodialysis patients	Data analysis completed	Intervention	2025-04-23	<NULL>	<NULL>	7948	The effectiveness of respiratory muscle training combined with physiotherapy in hemodialysis patients: a randomized study.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-05	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-3xqdph2	<NULL>	Individuals with chronic renal failure undergoing hemodialysis in the Nephrology Department of the Hospital for at least three months of hemodialysis; of both sexes; between 18 and 70 years old; in stable clinical conditions	Patients who will undergo kidney transplantation during the intervention period; who are unable to understand and follow the research protocols; people in wheelchairs; who have medical contraindications to performing physical and/or breathing exercises; those who do not agree to sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:17
RBR-9rsrk6h	How laser treatment can relieve knee pain caused by arthritis	Data analysis completed	Intervention	2025-04-28	<NULL>	<NULL>	7961	Effect of Low-Level Laser Therapy in Patients Diagnosed with Knee Osteoarthritis	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-03-13	Universidade Federal do Amazonas	Instituto de Saúde e Biotecnologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9rsrk6h	<NULL>	Individuals of both sexes. Age between 50 and 74 years old. Diagnosis of symptomatic knee osteoarthritis. Minimum pain intensity of 3 on the Visual Analog Scale (VAS). Meet the classification criteria of the American College of Rheumatology, including: joint pain; functional changes; presence of crepitus in the knee; joint stiffness lasting an average of 30 minutes; presence of osteophytes identified by imaging studies. Pain and functional disability in the knee for at least 3 months. Radiographic classification between grades 2 and 4 on the Kellgren–Lawrence scale	Individuals with the following complications: neoplasms; dementia; neurological deficits (sensory or motor); uncontrolled systemic arterial hypertension; patients using antidepressants; or who had acute infections; vascular complications; epilepsy; gravid uterus; burns as well as patients using pacemakers and patients using anti-inflammatory or analgesic medications; symptomatic hip OA; acute diseases; other rheumatic diseases; systemic or orthopedic that could interfere with the results and the performance of the tests; all these cases were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-6khstfv	Breastfeeding and Buzzy® in reducing pain during childhood vaccination: randomized clinical trial	Data analysis completed	Intervention	2025-04-28	<NULL>	<NULL>	7964	Pain management and the use of technologies in nursing care during childhood vaccinations	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-12	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6khstfv	<NULL>	Infants of both genders; aged two to twelve months; breastfed; who attended the sector to receive the pentavalent vaccine, at the time of data collection, accompanied by a legal representative, over 18 years old and who demonstrated consent for the infant&apos;s participation in the investigation	Infants who have not received the pentavalent vaccine for any reason; infants with a history of treatment with prophylactic analgesics within a period of up to eight hours prior to the administration of the vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-2dx9m4h	Change in grip strength induced by overflow contralateral to hip flexion	Data analysis completed	Intervention	2025-05-03	<NULL>	<NULL>	7980	Change in grip strength induced by overflow contralateral to hip flexion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2dx9m4h	<NULL>	They were aged between 18 and 30 and had a motor preference for the right upper limb.	Volunteers with orthopaedic alterations, pain, difficulty in performing the palmar grasp and hip flexion movements, and failure to achieve at least 70 per cent of the maximum hip flexion force.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-9x6yxbv	Characterization of patients and evaluation of drug treatment for Multiple Sclerosis	Data analysis completed	Observational	2021-12-29	<NULL>	<NULL>	7986	Epidemiology and oral disease-modifying therapies for Multiple Sclerosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9x6yxbv	<NULL>	Individuals over 18 years of age; of both sexes; diagnosed with Multiple Sclerosis represented by the G-35 code, which encompasses the group of diseases of the nervous system in the 10th edition of the International Statistical Classification of Diseases and Related Health Problems (ICD 10); assisted by the Specialized component of the Pharmaceutical Assistance of Mato Grosso do Sul; undergoing treatment, for at least three months, with one of the following oral administration medications: Teriflunomide 14mg, Dimethyl fumarate 240mg or Fingolimod 0.5mg; with at least one result of the Expanded Disability Status Scale (EDSS) prior to and one subsequent to the initiation of treatment with the oral medications described above	Individuals with cognitive alterations that make it difficult to remember facts related to their illness; individuals with cognitive alterations that make it difficult to understand the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-55swq5	Evaluation of Dental Bleaching with 35% Hydrogen Peroxide compared with LED application	Data analysis completed	Intervention	2019-09-20	<NULL>	<NULL>	8006	Clinical evaluation of Dental Bleaching with 35% Hydrogen Peroxide compared with LED violet application - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Norte do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-55swq5	<NULL>	Patients with good general health will be included; age between 18-50 years of age; good oral hygiene; absence of caries in the anterior and inferior teeth; absence of palatal and vestibular restorations; upper canine with A2 or darker shading, which will be evaluated with Vita Classical scale (VITA Classical Shade, Vita Zahnfabrik, Bad Säckingen, Germany).	Patients will be excluded: undergoing previous bleaching procedures; That have restorations on the anterior superior teeth; Who have canal treatment in the anterior teeth; Pregnant and / or breastfeeding; With severe internal discoloration (tetracycline, spots, fluorosis, non-vital teeth); Parafunctional habits such as bruxism; Or any other pathology that may cause sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-3q9vgk9	Effects of dietary restriction of ultra-processed foods on the health of individuals with excess weight	Data analysis completed	Intervention	2023-04-18	<NULL>	<NULL>	8012	Effectiveness and metabolic impacts of restricting the consumption of ultra-processed foods on metabolic adaptation and weight regain in individuals with excess weight submitted to caloric restriction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Univerisidade Federal de Alagoas	Univerisidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3q9vgk9	<NULL>	Adult individuals (19-60 years old); with the wish to lose weight; with a stable weight for at least 1 month; with obesity defined by two of the following three criteria: body mass index between 25 and 40 kg/m2, waist circumference bigger or equal to 88 cm for women and bigger or equal to  102 cm for men, body fat percentage of 35% for women and 25% for men determined by bioelectrical impedance	Individuals using chronic medications (anti-diabetics, anti-retrovirals, immunosuppressants, anti-depressants) or on hormone replacement; those with a condition that makes it impossible to carry out anthropometry or measure the components of energy expenditure; menopause, pregnant or lactating women; those who have already undergone any surgical intervention for weight loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-104n8kqh	Comparison between Sodium Fluoride Varnish and Titanium Tetrafluoride Varnish to prevent White Spots in Orthodontics	Data analysis completed	Intervention	2021-07-14	<NULL>	<NULL>	8021	Prevention and Remineralization of White Spot Lesions in Orthodontics: comparison of the efficacy of Sodium Fluoride Varnish and Titanium Tetrafluoride (TiF4) Varnish	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104n8kqh	<NULL>	Age between 11-18 years; both sexes; complete permanent dentition; having at least one active white spot lesion on the smooth surfaces of the permanent dentition (Nyvad index score 1); being under orthodontic treatment with a fixed appliance initiated between 6-18 months	Patients with cavitated caries lesions; who have undergone topical fluoride application in the past 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-56nsh92	Effects of meals rich in ultra-processed foods on the metabolism of overweight individuals	Data analysis completed	Intervention	2023-07-11	<NULL>	<NULL>	8028	Effects of meals rich in ultra-processed foods compared to meals without ultra-processed foods on energy metabolism, satiety hormones, and autonomic function in individuals with excess weight	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Univerisidade Federal de Alagoas	Univerisidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-56nsh92	<NULL>	Individuals aged between 19 and 60, with obesity defined by 2 of the 3 following criteria: body mass index between 25 and 40 kg/m2; waist circumference greater than or equal to 88 cm for women and greater than or equal to 102 cm for men; body fat percentage greater than or equal to 35% for women and greater than or equal to 25% for men, determined by bioelectrical impedance; who want to lose weight, but who have had a stable weight for at least 1 month at the time of inclusion	Individuals using chronic medications (antidiabetics, antiretrovirals, immunosuppressants, antidepressants); celiac or gluten-sensitive individuals; vegetarians or vegans; who have a condition that makes it impossible to perform anthropometry or measure the components of energy expenditure; menopausal women; pregnant women or nursing mothers; or who have already undergone any surgical intervention for weight loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-8s8tz32	Risperidone and Clonazepam combined by oral solution with intramuscular Haloperidol Agitation by Psychosis	Data analysis completed	Intervention	2023-08-16	<NULL>	<NULL>	8038	Comparison of Risperidone and Clonazepam combined by oral solution with intramuscular Haloperidol as monotherapy in psychomotor agitation of psychotic patients	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Federal do Tocantins	Universidade Federal do Tocantins	https://ensaiosclinicos.gov.br/rg/RBR-8s8tz32	<NULL>	Patients in psychomotor agitation scored by the Behavioral Activity Rating Scale (BARS)=6; who did not use any psychoactive drugs in the last 7 days; with mental illness; patients with psychotic disorder or bipolar disorder; age between 18 and 50 years old; both sexes	Acute intoxication states; delirium;  withdrawal syndrome; mental disorder of organic origin; refusal to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-25k53m	Comparing two doses of Botulinum toxin A in the treatment of urinary symptoms	Data analysis completed	Intervention	2017-01-25	<NULL>	<NULL>	8080	A prospective randomized clinical trial comparing different doses of Abobotulinum toxin A in the treatment of Idiopathic Detrusor Overactivity	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2013-07-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-25k53m	<NULL>	Female partients; aged 18 years or older; diagnosis of idiopathic overactive bladder; refractoriness to treatment with behavioral measures and pharmacological therapy; or contraindication to the use of anticholinergics	Patients with cognitive deficit; extensive fibroids; tumors; grade III and IV prolapses; changes in bladder emptying, with high residue (above 150mL) or use of catheterization previously or repeat UTIs; predominant stress urinary incontinence; prior treatment with the toxin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-2m7w87r	Effect of Protein and Carbohydrate Supplementation Associated with Resistance Exercise as a Treatment for Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2025-06-30	<NULL>	<NULL>	8087	Effect of Protein and Carbohydrate Supplementation Associated with Resistance Exercise as an Adjunct in the Treatment of Type 2 Diabetes Mellitus: A Randomized, Triple-Blind Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-19	Universidade São Judas Tadeu	Faculdade de Medicina da  Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2m7w87r	<NULL>	Diabetes Mellitus type 2 (DMT2)  with a stable medication dose (oral antidiabetics, insulin, or a combination of both) for three or more months; glycated hemoglobin between 6% and 9.0%; renal function assessed by the Modification of Diet in Renal Disease (MDRD) above 60 ml/h; no untreated or decompensated chronic non-communicable disease; male sex; age between 65 and 79 years	Inability to undergo assessments and reassessments; having more than three absences during the training period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-8y6j7w3	Evaluation of a brain stimulation technique for the treatment of people with cocaine dependence	Data analysis completed	Intervention	2025-07-01	<NULL>	<NULL>	8088	Transcranial Magnetic Stimulation in the treatment of Cocaine Dependence: evaluation of efficacy in a clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2024-10-01	Santa Casa de Misericórdia de Belo Horizonte	Santa Casa de Misericórdia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-8y6j7w3	<NULL>	Being diagnosed with cocaine dependence according to the Diagnostic and Statistical Manual of Mental Disorders DSM-5 criteria. Age between 18 and 70 years. Undergoing treatment at the Psychosocial Care Center for Alcohol and Drugs CAPS AD for at least six months. Having stable use of psychotropic medications if applicable for at least three months prior to the start of the study. Both sexes	Have a history of electroconvulsive therapy (ECT). Brain implants. Stroke or traumatic brain injury in the last 12 months. Diagnosis of epilepsy. Diagnosis of brain malformations. Diagnosis of schizophrenia. Use of medications that interfere with cortical excitability. Hypersensitivity to magnetic stimuli	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-9r7yhzk	Biopsychosocial perspective of the home environment of children born with Gastroschisis: observational study	Data analysis completed	Observational	2025-07-11	<NULL>	<NULL>	8119	Evaluation of physical growth, body composition, and neuropsychomotor development of patients with Gastroschisis over the first two years of life: cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Instituto Fernandes Figueira - IFF/ FIOCRUZ	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9r7yhzk	<NULL>	Children born with simple or complex gastroschisis; both sexes; between 3 and 4 months of corrected chronological age	Children with genetic syndromes; other congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-2wbrh3t	Multicenter Clinical Trial  for the Treatment of Dry Eye and Meibomian Gland Dysfunction whit iLUX	Data analysis completed	Intervention	2022-07-08	<NULL>	<NULL>	8125	Evaluate the effect of heat application by light emission and compression under direct observation with the iLUX device for the treatment of Dry Eye and Meibomian Gland Dysfunction	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-02-01	Clínica Oftalmológica Pereira Gomes	Clínica Oftalmológica de Antioquia	https://ensaiosclinicos.gov.br/rg/RBR-2wbrh3t	<NULL>	Age over 18 years; Patients who signed the consent form; Availability to attend all study visits; Positive history of dry eye symptoms prior to the study, using ocular surface disease index  greater than or equal to 13 at patient&apos;s first visit; Evidence of Meibomian gland disfunction, diagnosed by a clinician not involved in the study and defined as a Meibomian gland secretion score less than 12 in 15 glands assessed in the lower eyelid; Non-invasive tear film break-up time (NIBUT) less than 10 seconds using the Keratograph 5M; Consent/ability to abstain from other dry eye/Meibomiun gland disfunction medications during the time between the screening visit and the end of the study;	Ocular surgery in the last 6 months; Cicatricial lid margin disease (symblepharon) identified by slit-lamp examination; Active ocular infection or active ocular inflammation or history of chronic, recurrent ocular inflammation within the prior 3 months; Treatment with LIpiFlow or Intense Pulsed Light Therapy in the previous 12 months; Treatment with omega-3; Use of topical cyclosporine; Use of topical steroids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-4x7w9kj	How patients perceive the preoperative use of Passiflora Incarnata in wisdom tooth extraction	Data analysis completed	Intervention	2025-07-14	<NULL>	<NULL>	8126	The patient&apos;s perception of the preemptive use of Passiflora Incarnata in third molar extraction	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Pró Reitoria de Pesquisa da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4x7w9kj	<NULL>	Be between 18 and 40 years old; both genders; have two asymptomatic homologous third molars (upper or lower); same classification as Pell and Gregory and Winter for homologous teeth; same angulation of the third molars in relation to the second molars	Pregnant; lactating; American Society of Anesthesiologists (ASA) classification as patient III or IV; history of use of medication for pain or anxiety in the 15 days prior to the study; history of hypersensitivity to substances or materials used in the experiment; patients unable to undergo surgical procedures with local anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-2qvhp8w	Frailty Assessment, Telomere Length, and Postoperative Outcomes in Cardiac Surgery Patients	Data analysis completed	Observational	2025-07-17	<NULL>	<NULL>	8137	Funtionality Assessment and Telomere Length to predict surgical complications in patients undergoing Cardiac Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2qvhp8w	<NULL>	Volunteers undergoing elective cardiac surgery for myocardial revascularization or to correct heart valve diseases with cardiopulmonary bypass; over 18 years old; all genders; all ethnicities	Emergency surgery; other associated cardiovascular procedure; acute myocardial infarction  less than 30 days before operation; unstable angina;  orthopedic or neurologic disorders that prevented or made it difficult to perform the functional tests; functional class IV of the NYHA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-10yk36ht	Study to evaluate hydration in the prevention of blemishes after varicose vein treatment	Data analysis completed	Intervention	2025-07-29	<NULL>	<NULL>	8163	Prospective study of the impact of skin hydration on the incidence of post-sclerotherapy hyperpigmentation	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-02-10	Universidade Federal do Rio Grande	Irmandade Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10yk36ht	<NULL>	women. fitzpatrick III to IV. formal indication to sclerotherapy	Men. Patients &lt; 18 years old. patients with any contraindication to the sclerotherapy procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-9qzb5r6	Impact of a Modality of Integrative and Complementary Health Practices in Primary Care: results from a mixed-methods study	Data analysis completed	Intervention	2025-07-30	<NULL>	<NULL>	8166	Assessment of a modality of Integrative and Complementary Health Practices in Primary Health Care: a mixed-methods study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Faculdade de Saúde Pública da USP	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9qzb5r6	<NULL>	Age 18 years or older; of both sexes; complaint of musculoskeletal pain symptoms in any part of the body for more than 3 months	Age below 18 years; with no musculoskeletal pain for more than 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-10mcrfkq	Home monitoring of possible complications using the Meu PICC app in people with a central catheter inserted in the arm and treated in a day hospital	Data analysis completed	Intervention	2025-07-30	<NULL>	<NULL>	8170	Extra-hospital monitoring of complications by application Meu PICC in patients using peripherally inserted central catheter attended in a day hospital: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-27	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10mcrfkq	<NULL>	Age equal to or greater than 18 years; have a smartphone with camera and internet access with proficiency in its use; home use of peripherally inserted central catheter PICC for medication administration; follow-up at the day hospital of the referring institution; both genders	Referred or perceived psychiatric illness; reported or perceived cognitive or sensory impairment without caregiver; terminal illnesses (such as cancer with metastases); difficulty in communication; without a caregiver; patients without return to the day hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-7jsmd3j	Study of efficacy and safety of a new Reusable Device used in Adrenal Gland Videosurgery	Data analysis completed	Intervention	2025-08-01	<NULL>	<NULL>	8179	Clinical validation of a new Reusable Balloon Trocar for dissection in Retroperitoneoscopic Adrenalectomy	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2020-11-26	Hospital Nossa Senhora da Conceição	Hospital Militar de Área de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7jsmd3j	<NULL>	Patients aged 18 or over; male and female; with adrenal tumors with indication for surgical removal after functional and imaging analysis; treated at the Clinical and Surgical Endocrinology outpatient clinic of Hospital Nossa Senhora da Conceição in Porto Alegre; and discussed in a monthly multidisciplinary Tumor Board meeting	Patients with a Body Mass Index (BMI) greater than 35; patients with a history of pyelonephritis ipsilateral to the adrenal tumor; tumors larger than 6 cm; tumors smaller than 4 cm and non-hypersecretory; tumors with invasion of adjacent structures (vena cava, kidney, duodenum) suggestive of adrenal carcinoma on imaging (Computed Tomography); patients with previous retroperitoneal surgery ipsilateral to the adrenal tumor or history of trauma; patients with contraindications or high risk for general anesthesia; malfunction of the Sonicision ultrasonic coagulator forceps in which it cannot be replaced or is not available	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-2ch5z38	Effect of reading an e-book by dentistry students to gain knowledge about early loss of anterior deciduous teeth and creation of a support and guidance tool for parents about dental trauma to baby teeth	Data analysis completed	Intervention	2025-08-05	<NULL>	<NULL>	8183	The use of a book in digital format by undergraduate students to acquire knowledge about the early loss of deciduous anterior teeth	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-11	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro UFRJ	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-2ch5z38	<NULL>	Students over 18 years of age; regularly enrolled in any period of the Undergraduate Dentistry course at the Federal University of Rio de Janeiro (UFRJ) in the second semester of 2023; both genders	Students under 18 years of age; who are not enrolled in any period of the Undergraduate Dentistry course at the Federal University of Rio de Janeiro (UFRJ) in the second semester of 2023	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-9pzj4vz	Breast diagnostic study by Magnetic Spectroresonance	Data analysis completed	Observational	2025-08-05	<NULL>	<NULL>	8185	Accuracy assessment of Breast Spectroscopy by Magnetic Resonance	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-09-20	Hospital da Clínicas da Universidade Federal de Goiás	Centro Avançado de Diagnóstico da Mama (CORA)	https://ensaiosclinicos.gov.br/rg/RBR-9pzj4vz	<NULL>	Women over 18; who agreed to participate in the study and signed the Free and Informed Consent Form; Health Unique System (SUS) users as BI-RADS 4 and 5 with breast anomaly or diagnosed by mammography and/or ultrasound and who have already received a recent diagnosis of breast cancer and who will be referred for incisional, excisional or reexcisional biopsy	Patients who present a high level of claustrophobia as we understand that the patient&apos;s non-cooperation could compromise the exam; pacemaker; surgical clips for aneurysms; bearers of neurostimulators; pregnant patients; and patients suffering from gunshot wounds with a projectile lodged and not removed; in addition to a previous history of reaction to gadolinium; women who were not the minimum age required for the study; did not agree to participate in the study or refused to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-858cd68	Efficacy of Bromelain in controlling pain, edema and trismus after third molar extractions	Data analysis completed	Intervention	2025-08-05	<NULL>	<NULL>	8188	Comparative analysis of the effectiveness of Bromelain versus Ibuprofen in the control of pain, edema and trismus after toohth extractions	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2023-09-15	Universidade de Pernambuco - Multicampi Garanhuns	Universidade de Pernambuco - Reitoria	https://ensaiosclinicos.gov.br/rg/RBR-858cd68	<NULL>	Indication of complicated extractions or bilateral lower third molars; teeth indicated for extraction must present the same degree of difficulty for removal; participants of both sexes; participants must be between 18 and 35 years old; healthy participants (ASA I) and with controlled systemic diseases (ASA II); absence of infectious process at the surgical site; not having used antimicrobials, anti-inflammatories or analgesics in the last two weeks	Participants allergic to nonsteroidal anti-inflammatory drugs, bromelain derivatives, and dipyrone; patients with missing upper and lower incisors or prostheses due to the impossibility of measuring mouth opening; patients with a history of blood dyscrasias or chronic pain; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-7jhxrv9	Influence of age on reported sensitivity after bleaching treatment	Data analysis completed	Intervention	2025-08-08	<NULL>	<NULL>	8191	Influence of age on sensitivity to dental clarification of consulting: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-03	Universidade Federal do Amazonas	Faculdade de Odontologia - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-7jhxrv9	<NULL>	Volunteers between 14 and 18 years old and between 31 and 50 years old; of both genders; dissatisfied with the color of their teeth; no systemic diseases (metabolic, heart and immunological diseases); oral condition without periodontal disease; selected after publication on posters and guidelines within the scope of the Dentistry faculty clinic; at least two central incisors or canines with color A2 or darker; the six upper front teeth free of restorations on the palatal and buccal surfaces; healthy enamel and without pathological, physiological and medicinal changes	Use of orthodontic braces; severe crowding; presence of intrinsic stains (tetracycline staining, fluorosis, pulped teeth); using anti-inflammatory drugs and antioxidant analgesics, which may mask sensitivity; smokers; alcoholics; pregnant or breastfeeding women; participants who have already undergone a whitening procedure; participants with bruxism, or significant oral pathologies; participants with exposed dentin in the incisal portion of the anterior teeth; with non-carious cervical lesions; patients who reported previous sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-8s839dj	Selfcervix: Self-collection strategy for cervical Cancer screening	Data analysis completed	Intervention	2025-08-11	<NULL>	<NULL>	8201	Analysis of alternative methods for cervical Cancer screening	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-24	Hospital Universitário da Universidade de São Paulo	Ziel Biosciences Pesquisa, Desenvolvimento e Diagnóstico LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8s839dj	<NULL>	Women between 25 and 65 years old referred for colposcopy due to Pap smear with suspicious changes of neoplastic cervical lesions and/or positive HPV (Human Pappiloma Virus) PCR (Polymerase Chain Reaction).  All must agree to participate and sign the Free and Informed Consent Form in advance.	"Pregnant women; immunocompromised women; women who have not yet started
sexual activity; or those who have already undergone chemotherapy or
radiotherapy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-67jkxsj	Effect of Topical Melatonin Gel on the healing of post-extraction sites	Data analysis completed	Intervention	2025-08-12	<NULL>	<NULL>	8202	Evaluation of the effect of Melatonin Gel on post-extraction Dental Socket preservation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Comando da Aeronáutica	Programa de Pós Graducação em Odontologia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-67jkxsj	<NULL>	Healthy volunteers over 18 years of age; of either gender; with an indication for the extraction of premolar or molar teeth from any dental arch who have adjacent teeth present; and are willing to cooperate with the study	Volunteers presenting with teeth affected by acute periapical or periodontal infections (abscesses); those with severe systemic diseases or under medications such as chemotherapy, anticoagulants, corticosteroids, antiresorptive drugs, or immunosuppressive agents; patients using systemic melatonin; individuals with decompensated chronic diseases; metabolic bone disorders; any motor dysfunction that impairs or prevents proper oral hygiene; smokers (former smokers must have ceased smoking for at least 6 months); pregnant women; and patients who have undergone radiotherapy within the past 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-29fjs5r	Clinical study of two biomaterials used to control bleeding after extraction of mandibular third molars	Data analysis completed	Intervention	2025-08-18	<NULL>	<NULL>	8213	Randomized clinical study of two hemostatic agents in dental socket of mandibular third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Programa de Pós-Graduação em odontologia da Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-29fjs5r	<NULL>	The physical criteria included research participants with bilateral third molars indicated for extraction; aged between 18 and 40 at the time of recruitment; both genders; the psychological criteria for participation in the project comprised patients with no history of anxiety; mood; eating; or psychotic disorders that could compromise their participation and collaboration in the study; these were evaluated by completing an anamnesis form	All research participants who smoked; were dependent on alcohol; had systemic diseases (eg, diabetes, blood dyscrasias) were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-35478mr	Herbal tea as a preoperative tranquilizer: clinical trial	Data analysis completed	Intervention	2025-09-04	<NULL>	<NULL>	8254	Tea composed of herbs as a pre-operative anxiolytic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Regional Integrada do Alto do Uruguai e das Missões - URI - Campus	Universidade Regional Integrada do Alto do Uruguai e das Missões - URI - Campus	https://ensaiosclinicos.gov.br/rg/RBR-35478mr	<NULL>	Volunteers aged between 18 and 65; both sexes; who will perform elective surgery	Individuals with psychiatric disorders; gastroesophageal reflux; diabetics;pregnant women; and those with gastropathies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-7t6d8z5	Microneedling to improve the appearance of skin scars	Data analysis completed	Intervention	2025-09-05	<NULL>	<NULL>	8256	Treatment of Atrophic Scars with Microneedling	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Centro de Pós Graduação da Faculdade Ciências Médicas de Minas Gerais	Centro de Pós Graduação da Faculdade Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7t6d8z5	<NULL>	Patients aged between 18 and 70 years.Diagnosis of atrophic scars.Patients who provide their informed consent to participate in the study.Of both sexes	Patients who do not wish to have their data used in the study.Patients with malignant tumors.Patients who do not wish to have their data used in the study.Pregnant and breastfeeding women.Patients who are not taking contraception and have an active sex life at the time of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-96hpf7j	How Exercise and a Low-Calorie Diet can improve breathing during effort in people with Metabolic Syndrome	Data analysis completed	Intervention	2025-09-09	<NULL>	<NULL>	8266	Effect of Physical Training and Hypocaloric Diet on ventilatory efficiency during progressive exercise in patients with Metabolic Syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-15	Universidade Federal de São Paulo	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-96hpf7j	<NULL>	Sedentary women; between 18 and 50 years old; with Metabolic Syndrome, according to the National Cholesterol Education Program, Adult Treatment Panel III criteria.	Women enrolled in other physical training programs; undergoing dietary treatment; smokers; with a history of alcohol consumption; with cardiovascular disease or a metabolic condition beyond those already included in Metabolic Syndrome; with less than 75% participation in physical training sessions; who experience changes in medication during the experimental protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9xyvcyn	Comparation between Passiflora Incarnata X Valeriana Officinalis for conscious sedation in extration of the wisdom teeth surgery	Data analysis completed	Intervention	2025-09-11	<NULL>	<NULL>	8272	Evaluation of the actions of Passiflora Incarnata X Valeriana Officinalis for conscious sedation in anxious patients subjected to mandibular third molar extraction - a prospective, double-blind, split-mouth, and randomized study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-07-01	Centro de Ciências da Saúde da Universidade Estadual de Maringá	Departamento de Odontologia da Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-9xyvcyn	<NULL>	ASA I and II physical classification from the American Society of Anesthesiologists; individuals aged 17 years or older; both sexes; asymptomatic bilateral impacted mandibular third molars in similar surgical positions; patients anxious about undergoing the procedure	Patients taking antidepressant and anxiolytic drugs; History of severe respiratory deficiency, obstructive sleep apnea, alcoholism, narrow-angle glaucoma, myasthenia gravis, congestive heart failure, liver and/or kidney problems, and the use of other depressant drugs; Pregnancy and/or lactation; History of local infections, such as pericoronitis; Hypersensitivity to any component of medications, substances, or materials used in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-8djspm4	Influence of surgical position on head pressure during general anesthesia	Data analysis completed	Observational	2025-09-12	<NULL>	<NULL>	8274	Influence of body position on intracranial pressure during general anesthesia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-20	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital Nove de Julho - Rede Ímpar	https://ensaiosclinicos.gov.br/rg/RBR-8djspm4	<NULL>	Patients over 40 years of age; undergoing elective gastrointestinal, urological or gynecological surgeries; without previous cognitive alterations; Signature of the consent form	Patient refusal to participate in the clinical trial; previous cognitive alterations; history of ischemic stroke or other previous neurological pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-3vcjrq5	How do individuals with HIV feel when performing Intense Exercise?	Data analysis completed	Intervention	2025-09-12	<NULL>	<NULL>	8275	Acute effect of High-Intensity Interval Training on immunological parameters, cardiac autonomic control and psychophysiological responses of people living with HIV: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Departamento de Educação Física da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	https://ensaiosclinicos.gov.br/rg/RBR-3vcjrq5	<NULL>	men with HIV; between 18 and 45 years of age; who have been on ART for at least 6 months; medical authorization to practice physical exercise; physically active for at least 1 month	Individuals with any musculoskeletal limitation that prevents exercise; history of cardiovascular disease; use of illicit drugs; smokers; alcoholics; those who did not follow the evaluation recommendations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2t3s88z	Comparison of cost and quality of life in the treatment of varicose veins by normal surgery and by radiofrequency treatment at Hospital de Américo Brasiliense (SUS)	Data analysis completed	Intervention	2025-09-15	<NULL>	<NULL>	8278	Cost-Effectiveness and Quality of Life Study of Safena Magna Treatment by Radiofrequency Ablation and Conventional Surgery at Hospital Estadual de Américo Brasiliense (SUS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2t3s88z	<NULL>	Symptomatic lower limb varicose veins; age over 18 and under 80; presence of total or partial reflux of the great saphenous vein of one or both or limbs, detected on duplex ultrasound with indication for surgical treatment	Significant underlying diseases in activity such as cancer, lupus, tuberculosis; infectious disease (infected ulcers); history of clotting disorders (thrombophilia); history of thromboembolic events (deep vein thrombosis); use of anticoagulant or antiplatelet medication; pregnancy; high cardiovascular risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-4bcwft2	Evaluation of the cardiovascular response to resistance training in individuals with stroke	Data analysis completed	Intervention	2025-09-17	<NULL>	<NULL>	8286	Evaluation of the cardiac autonomic response to resistance training in individuals with stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-4bcwft2	<NULL>	Women; 40 years or older; diagnosis of hemorrhagic or ischemic stroke for at least 3 months	History of acute trauma-orthopedic changes (equal to or less than 3 months) on the side not affected by the stroke; uncontrolled diseases that alter the functional capacity to carry out the training program; cognitive, visual and hearing changes that interfere with understanding commands, explanations and completing questionnaires; and attendance of less than 75% in training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9yfmhcx	Comparative study before and after speech therapy in patients with  Apnea	Data analysis completed	Intervention	2025-09-22	<NULL>	<NULL>	8295	Comparative pre- and post-study of an orofacial myofunctional therapy program in patients with Obstructive Sleep Apnea	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-26	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9yfmhcx	<NULL>	Adult patients; men and women; aged between 19 and 65 years; literate; diagnosed with obstructive sleep apnea confirmed by polysomnography regardless of the degree of apnea; with a body mass index less than 35 kg/m²; who participated in the 12 session therapeutic program lasting an average of 3 months; who underwent polysomnography again at the end of the program and signed the informed consent form	Male and female patients with other sleep disorders; previous apnea treatment; use of continuous positive airway pressure; intraoral appliances and surgery; use of alcohol; stimulants or sedatives; major craniofacial alterations; failure to comply with the therapeutic program; no polysomnography examination before or after the therapeutic program; or not accept the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-5n7cg2n	The effect of the Vivifrail exercise program on improving functional Capacity in elderly people living in a geriatric home	Data analysis completed	Intervention	2025-09-22	<NULL>	<NULL>	8302	Efficacy of the Vivifrail program in improving Functionality in institucionalized elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5n7cg2n	<NULL>	Elderly people of both sexes; aged 60 or over; be available to participate in functional tests; capable of understanding and carrying out the proposed activities	Elderly individuals who have cognitive deficits; musculoskeletal or joint injuries that prevent them from participating; who have decompensated heart; respiratory or metabolic disease; or any health condition that could significantly compromise the elderly individual&apos;s performance in the assessment tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-767cyvb	Effects of Florals on anxiety, quality of sleep and quality of life of medicine students	Data analysis completed	Intervention	2025-09-23	<NULL>	<NULL>	8305	Evaluation of the effects of Floral Essences on anxiety, quality of sleep and quality of life of medicine students from a university in south Brazil: a clinical trial randomized and controlled	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-08	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-767cyvb	<NULL>	Healthy medical students; from UNISUL; who do not have any diagnosed disease and/or are not undergoing treatment; both genders	Students with immunosuppressive diseases; oncological diseases; infectious diseases; or in a febrile state; epilepsy; diagnosed with depression; pregnant and/or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-43q97jm	The role of inflammatory substances and cell stress in Inflammatory Bowel Disease	Data analysis completed	Intervention	2025-09-23	<NULL>	<NULL>	8306	Oxidative stress and cytokine activity in Inflammatory Bowel Disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-13	Fundação de Amparo à Pesquisa do Estado do Piauí - FAPEPI	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-43q97jm	<NULL>	Both sexes. Aged between 20 and 59. Clinical diagnosis of ulcerative colitis. Non-smokers. No comorbidities such as diabetes, hypertension, kidney failure, cardiovascular disease, rheumatic diseases or other diseases with inflammatory processes. Not using a vitamin-mineral supplement that interferes with zinc metabolism. Not be currently using monoclonal antibody therapy. Participants linked to the Association of Crohn&apos;s Disease Patients of the North and Northeast of Brazil (ACROHNN). Follow-up at the University Hospital of the Federal University of Piauí (HU-UFPI)	Start of monoclonal antibody therapy during the study. Change of city or state. Lack of telephone contact. Inability to continue using the supplement. Absence from biological material collection. Age group outside the 20-59 age range. No relationship with ACROHNN. No follow-up by HU-UFPI. Diagnosis of an intestinal disease other than Ulcerative Retocolitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8h45h43	Altitude-simulated Training applied to team sport athletes	Data analysis completed	Intervention	2025-09-26	<NULL>	<NULL>	8316	Acute and chronic responses to Inter-effort Recovery Hypoxia associated with Small-sided Games and Sprint Interval Training in team sport athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Escola de Educação Física e Esporte de Ribeirão Preto, Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8h45h43	<NULL>	Male handball athletes aged between 18 and 35 years	Failure to complete two or more sessions of the chronic protocol; failure to complete one session of the acute protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-2h5rwgb	Embolization of the knee arteries to relief Chronic Pain using Imipenen/Cilastatin versus Microspheres	Data analysis completed	Intervention	2021-07-20	<NULL>	<NULL>	8319	Randomized clinical trial of Genicular Artery Embolization using Imipenem/Cilasatin versus Microspheres for the treatment of Chronic Knee Pain	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-02-01	Invasc - Instituto Vascular de Passo Fundo	Hospital de Clínicas de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2h5rwgb	<NULL>	Diagnosis of knee ostheoartritis; Knee pain for more than 6 month; Refractory to conservative treatment - at least 3 months of physical therapy and/or parenteral pain medication and/or corticosteroid knee infiltration with no clinical improvement; Kellgreen-Lawrence classification I to III in the knee X-ray; Comproved sinovitis in the magnetic resonance; Wiling to participate and to sign the consentment term; Willing to follow up; It has to be in hospital due to refractory knee pain.	Indication to total knee replacement, Kellgreen-Lawrence grade IV; No conservative measure performed before enrollment; Previous knee arthroplasty; Patients with Rheumatoid arthritis or infectious arthritis; Patients with fybromialgia; Deposit corticosteroid 30 days prior to embolization; Patients with no cognitive conditions to participate to the procedure, informing where are the pain areas; Comproved allergy to iodine ou to any of the embolization agents; Comproved coagulopathy; Prothrombin activity time &lt;50%; INR &gt;1,5; Platelet count &lt;50.000/mm3; Serum creatinin  &gt; 2,0mg/dl; Not to sign consentment term or not to willing to participate of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-287z2nh	Inflammatory components of saliva and gingiva of teeth that will receive prosthetic crowns at different clinical stages and the influence of a treatment to control blood pressure on these components	Data analysis completed	Intervention	2025-09-29	<NULL>	<NULL>	8320	Inflammatory components in saliva and gingival crevicular fluid of teeth receiving metal-ceramic crowns at different clinical stages and the influence of the renin-angiotensin system on treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-287z2nh	<NULL>	Patients must not present with any form of periodontitis (e.g., aggressive, chronic, necrotizing); They must be between 30 and 60 years of age; without gender distinction; without race distinction; Participants must present with premolars indicated for restoration with metal-ceramic crowns, regardless of pulpal vitality; The teeth adjacent to those receiving crowns must exhibit the following characteristics: probing depth less than or equal to 3 mm, absence of bleeding on probing and attachment loss, and the presence of contralateral natural premolars; For inclusion in the experimental groups (under treatment with Angiotensin II Type 1 Receptor Blockers or Angiotensin Converting Enzime inhibitors), patients must have been undergoing such treatment for at least six months;	Presence of periodontitis; diagnosis of diabetes mellitus; smoking; pregnancy; lactation; iodine allergy; current orthodontic treatment; use of immunosuppressants; use of anticonvulsants; use of antibiotics; use of anti-inflammatory drugs; use of other classes of antihypertensive medications such as calcium channel blockers and beta-blockers;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-5p2xqqr	Diabetic neuropathy and recurrent laryngeal nerve involvement in patients undergoing thyroid surgery: evaluation of 50 cases	Data analysis completed	Observational	2025-09-29	<NULL>	<NULL>	8325	Comparative study between the values of recurrent laryngeal nerve latency in diabetic and non-diabetic patients undergoing thyroidectomy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-5p2xqqr	<NULL>	Volunteers of both sexes; age between 18 and 80 years; with or without a diagnosis of Diabetes; undergoing Elective Thyroidectomy Surgeries; laboratory tests collected within 90 days of the date of Surgery; signing of the informed consent form	Volunteers with comorbidities that could interfere with glycated hemoglobin values, such as Sickle Cell Anemia or Iron Deficiency; Blood Transfusion in the last year; Dialysis in the 90 days prior to the Surgical Procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-6jhtvfy	Use of Natalizumab in patients with Multiple Sclerosis	Data analysis completed	Observational	2022-05-02	<NULL>	<NULL>	8326	Impact of Natalizumab use in patients with Multiple Sclerosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-01	Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição da Universidade Federal de Mato Grosso do Sul	Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição da Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6jhtvfy	<NULL>	Patients diagnosed with Multiple Sclerosis, according to the 10th edition of the International Code of Diseases (ICD 10), classified as G35, diagnosed according to revised and adapted McDonalds criteria will be included in the research; of both sexes; aged over 18 years; who have been on natalizumab treatment for at least 3 months, presenting at least one Expanded Disability Status Scale (EDSS) assessment prior to the use of natalizumab and a subsequent assessment	Individuals with cognitive alterations that make it difficult to remember facts related to their disease and to understand the research will be excluded, as well as those who do not meet the inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-6zfzs4j	Comparison of the effect of three Benznidazole formulations for the treatment of Chagas Disease	Data analysis completed	Intervention	2025-09-30	<NULL>	<NULL>	8327	Comparative bioavailability study of three Benznidazole formulations after ingestion of a specific meal - STPh 02/22	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2022-10-01	Scentryphar Pesquisa Clínica Ltda	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6zfzs4j	<NULL>	Healthy volunteers; both genders; aged 18 to 50 years; body mass index between 19 and 30 kg/m²; willing to use condoms during the study and up to 7 days after the last dose of the medication; able to understand the nature and purpose of the study, including risks and adverse events	Pregnancy; breastfeeding; smoking; history of alcohol or drug abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-35hyxxv	Effectiveness of a remote-guided physical activity program	Data analysis completed	Intervention	2025-09-30	<NULL>	<NULL>	8331	Effectiveness of a remote-guided Physical Activity Program on the health of adolescents with Severe Obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-08	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35hyxxv	<NULL>	Adolescents aged 12 to 17 years with obesity (BMI z-score ≥ 2 for sex and age, according to WHO standards)	Disabling orthopedic or neurological conditions; inability to engage in regular physical activity; diagnosed mental disorders limiting adherence; participation in other structured weight loss or exercise programs (except school Physical Education); or lack of access to an internet-connected device with a camera.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-2n395mz	Physical Exercise during hemodialysis: the benefits for blood pressure, blood pressure, and mental health	Data analysis completed	Intervention	2025-10-02	<NULL>	<NULL>	8345	Effect of different types of Physical Exercises on dialysis efficiency, cognitive and physical aspects: a randomized controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	UNIVERSIDADE SÃO JUDAS TADEU - AMC SERVIÇOS EDUCACIONAIS S/C LTDA	UNIVERSIDADE SÃO JUDAS TADEU - AMC SERVIÇOS EDUCACIONAIS S/C LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2n395mz	<NULL>	Having Chronic Kidney Disease; of either sex; aged 18 or over; undergoing stable hemodialysis for at least three months	Possess any psychological disorders that make it impossible to understand the proposed study; present amputation and/or disability of lower limbs; pregnant women; high cardiovascular risk; changes in hemodialysis access; musculoskeletal complications; be a carrier of the human immunodeficiency virus (HIV); have any other relevant factor identified by the researchers that affects physical activity; have participated in any physical exercise program in the last three months, such as weight training and gymnastics, systematically	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-2vbfbh9	Animated infographic to guide hospital discharge of elderly patients with urinary catheters: a quasi-experimental study	Data analysis completed	Intervention	2025-10-06	<NULL>	<NULL>	8362	Animated infographic for hospital discharge of elderly people with indwelling urinary catheter: a quasi-experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-13	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2vbfbh9	<NULL>	Be 60 years of age or older, undergo urological surgery and keep the urinary catheter after hospital discharge	Elderly individuals who have used a urinary catheter at some point, as it is assumed they already know how to take care of themselves. Also, elderly individuals who are not cognitively capable of answering the questions in the data collection instrument	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-10dxtj89	Short-term Garlic Supplementation Enhances Salivary Antioxidant Enzyme Activity Following Exhaustive Exercise in Physically Active Middle-aged Men	Data analysis completed	Intervention	2025-10-06	<NULL>	<NULL>	8372	Investigation the Effect of Garlic Supplementation on Salivary Antioxidants Changes After an Exhaustive Exercise in Middle-aged Athlete Men	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-07	University of non-governmental Qadir	University of non-governmental Qadir	https://ensaiosclinicos.gov.br/rg/RBR-10dxtj89	<NULL>	Physically active men playing soccer 2 to 3 sessions per week; non-smokers; free from supplement use, chronic illness, injury, or oral infections	Inability or unwillingness to perform the exercise protocol to exhaustion; failure to complete the full supplementation period; engagement in vigorous or unaccustomed physical activity within 48 hours prior to testing sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-8mn88b2	Pollutant gas emissions in the treatment of Kidney Stones by External Shock Wave therapy compared to Laser Stone Fragmentation	Data analysis completed	Intervention	2025-10-06	<NULL>	<NULL>	8374	Carbon emission in the treatment of Ureteral Stones by Extracorporeal Shock Wave Lithotripsy compared to Transureteroscopic Ureterolithotripsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-06	University of São Paulo	University of Pittsburgh	https://ensaiosclinicos.gov.br/rg/RBR-8mn88b2	<NULL>	Consecutive patients aged over 18 years with symptomatic ureterolithiasis; who underwent primary lithotripsy at the Endourology Unit or the Emergency Department of the Hospital das Clínicas, Faculty of Medicine, University of São Paulo	Patients undergoing retreatment; pregnant women; those unable to continue treatment at the Institution; patients with ureteral stones smaller than 5 mm or larger than 15 mm; patients with active urinary tract infection or with coagulopathies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-66mcspw	Acupuncture and Cognitive-Behavioral Psychotherapy for the treatment of Anxiety in women	Data analysis completed	Intervention	2025-10-11	<NULL>	<NULL>	8391	The use of Integrative and Complementary Practices in the Brazilian Unified Health System for the treatment of Anxiety in women of reproductive age	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Organização Mogiana de Educação e Cultura Sociedade Simples Ltda	Organização Mogiana de Educação e Cultura Sociedade Simples Ltda	https://ensaiosclinicos.gov.br/rg/RBR-66mcspw	<NULL>	Women; aged between 18 and 49 years; with a clinical diagnosis of anxiety according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); presenting moderate to severe symptoms measured by the Hamilton Anxiety Rating Scale (HAM-A)	Pregnant women; women using anxiolytic or antidepressant medication; those undergoing other forms of psychotherapy or acupuncture; women with severe psychiatric or neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-63nvb2x	Speech therapy as an ally in the care of stubborn chronic cough	Data analysis completed	Intervention	2025-10-13	<NULL>	<NULL>	8394	Contributions of Speech-Language Pathology to the Treatment of Chronic Cough	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-12	Escola Paulista de Medicina da Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-63nvb2x	<NULL>	People over 18 years old; regardless of gender; diagnosed with Refractory chronic cough	Illiterate individuals; individuals without autonomy to provide assent to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-102wbfbj	Helping people with depression using positive mental imagery to change how they interpret situations	Data analysis completed	Intervention	2025-10-14	<NULL>	<NULL>	8412	The role of interpretation bias in depressive disorder and efficacy of positive imagery based interpretation bias modification on depressive disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	University of Social Welfare and Rehabilitation Sciences	University of Social Welfare and Rehabilitation Sciences	https://ensaiosclinicos.gov.br/rg/RBR-102wbfbj	<NULL>	Individuals aged 18 years or older. Both genders. Diagnosis of Major Depressive Disorder based on DSM-5. Mild to moderate depression severity based on BDI-II score. Ability to use a smartphone and internet. Consent to participate in the study	History of bipolar disorder or psychotic disorders. Active suicidal ideation. Substance abuse in the past six months. Participation in another psychological intervention during the study period. Cognitive impairment or neurological disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-86zkxm3	Foot Reflexology to Promote Women&apos;s Health During Menopause: An Holistic Approach	Data analysis completed	Intervention	2025-10-22	<NULL>	<NULL>	8443	Application of Foot Reflexology in promoting women&apos;s during the Climacteric: A holistic approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Cesumar	Universidade Cesumar	https://ensaiosclinicos.gov.br/rg/RBR-86zkxm3	<NULL>	Participants who reported being in the climacteric period regardless of having reached menopause; presenting complaints related to this phase such as headaches, night sweats, hot flashes, insomnia, fatigue, anxiety, irritability, vaginal dryness, and mental exhaustion; willing to answer all questions in the assessment instruments; signed the Free and Informed Consent Form; agreed with the study selection method based on simple random allocation; open to receiving the intervention protocol if allocated to the intervention group	Mulheres que apresentaram sintomas severos de saúde mental autoreferidos como transtornos de personalidade ou depressão profunda; incapacidades físicas ou cognitivas que impedissem a locomoção até o local de atendimento ou a resposta aos questionários; condições médicas pré-existentes nas quais a técnica aplicada fosse contraindicada como trombose venosa, epilepsia, gestação, infecções, lesões ou feridas abertas nos pés ou histórico de tuberculose; participantes que faltassem em duas sessões consecutivas também foram excluídas do estudo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-6gs2ss2	Non-Surgical Periodontal Treatment associated with Oral Hygiene in ICU patients	Data analysis completed	Intervention	2025-10-23	<NULL>	<NULL>	8446	Non-Invasive Periodontal Treatment Protocol associated with Mechanical Control and Oral  Biofilm Chemistry in ICU patients	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2022-02-08	Christiane Mazurek Moraes	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6gs2ss2	<NULL>	Patients aged ≥18  who reported the presence of teeth;  Patients hospitalized in the ICUs of the Pedro Ernesto University Hospital; and  with the possibility of performing the periodontal examination and supragingival scaling in the first 48 hours in the intervention group	Edentulous patients;  Pregnant or breastfeeding patients;  Intubated patients (orotracheal tube); Patients with orthodontic;  Patients allergic to chlorhexidine; Patients with lung images that could interfere with the diagnosis of pneumonia;  Patients with suspected or diagnosed pneumonia; Patients with cardiac pacemakers; Patients undergoing interventions by Oral and Maxillofacial Surgery and/or Head and Neck Surgery which would make periodontal examination impossible and Patients with coagulation problems and others contraindicated by the medical team	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-9qb8wsx	The effectiveness of Educational Initiatives on sexual abuse awareness among adolescents in public schools	Data analysis completed	Intervention	2025-10-31	<NULL>	<NULL>	8476	The impact of Educational Actions on knowledge of sexual abuse among adolescents in public schools	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Medicina de Jundiaí	<NULL>	<NULL>	<NULL>	Adolescents aged 15 to 19 years; students from the selected school; male and female	Not being a student in the second year at school	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:27
RBR-63jtrzs	Impact of macro-geometry on the initial bone repair process and primary stability of dental implants	Data analysis completed	Intervention	2025-11-03	<NULL>	<NULL>	8503	Impact of macro-geometry on the initial bone repair process and primary stability of dental implants: A prospective, controlled, randomized, split-mouth clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-02-04	Associação Unificada Paulista de Ensino Renovado Objetivo	<NULL>	<NULL>	<NULL>	Patient aged between 18 and 75 years, of both sexs, with total edentulism of the mandible and/or maxilla; patients with sufficient bone volume and height for implant placement	Use of antibiotics; continuous-use anti-inflammatories; phenytoin; cyclosporine; bisphosphonates in the 6 months prior to the study; presence of systemic changes or active infectious disease (diabetes, heart disease, hepatitis, etc.); smoking; pregnancy; breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:23
RBR-10nq323c	Study on the effect of Laser Light in relieving Muscle Pain in the pelvic floor of women with Chronic Pelvic Pain	Data analysis completed	Intervention	2025-11-10	<NULL>	<NULL>	8534	Study of the effect of Photobiomodulation on relieving Myofascial pain in the Pelvic floor of women with Chronic Pelvic Pain	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-07-13	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women; pelvic pain or genito-pelvic/penetration pain (GPPPD) for more than six months will be included; with a trigger point in the pelvic floor; aged between 18 and 45 years; sexually active with penetration (at least once a month); experiencing pelvic pain and pain during intercourse, with a score equal to or greater than four on the Numerical Rating Scale (NRS)	Women with obesity (body mass index [BMI] &gt;30); current urinary tract infection; leukorrhea (such as candidiasis or bacterial vaginosis); acute vulvar or vaginal lesions (e.g., Human papillomavirus, herpes, fissures); pregnant women; women with suspected pelvic cancer; pelvic organ prolapse beyond the hymenal ring during Valsalva maneuver; hypertrophic scars; vulvodynia; vaginismus; moderate to heavy menstrual leakage or increased and irregular uterine bleeding. During the study, patients who did not attend at least 70% of the sessions were excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:55
RBR-103bky8r	Activity of carvacrol and thymol in controlling bacterial accumulation on teeth and gum bleeding	Data analysis completed	Intervention	2025-11-19	<NULL>	<NULL>	8543	Activity of carvacrol combined with thymol in the control of supragingival dental biofilm and gingival bleeding: a longitudinal randomized clinical study	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-12-10	Departamento de Clínica Odontológica	<NULL>	<NULL>	<NULL>	Healthy volunteers; both genders which does not constitute a bias for this study; non-smokers; absence of dental caries; age between 18 and 60 years as they are adults; having 20 or more teeth in the oral cavity; presence of supragingival dental biofilm; presence of bleeding on probing; signing a free and informed consent form	Smoker volunteers; those who have used antibiotics in the last 3 months; those who present clinically detected periodontitis by periodontal probing and radiographic examination (serial imaging); presence of soft tissue lesions in the oral cavity; patients who present sites with &gt;=4mm probing depth; those who present teeth with extensive caries involving at least 10 teeth; holders of orthodontic devices; holders of ceramic or acrylic prostheses at least 10 dental crowns; patients who showed difficulties attending the clinic for periodic evaluations until the end of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:02
RBR-2mxrcjw	Comparative effects of Viscosupplementation and Triamcinolone on quality of life in patients with Knee Osteoarthritis	Data analysis completed	Intervention	2025-11-17	<NULL>	<NULL>	8561	Viscosupplementation and Triancinolone: impact on the quality of life of patients with Knee Osteoarthritis	<NULL>	4, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Faculdade Ingá - UNINGÁ	<NULL>	<NULL>	<NULL>	Patients of both sexes aged 45 or older. Diagnosis of symptomatic osteoarthritis (OA) of the knee. Diagnosis confirmed by radiological examination. Must have sought outpatient care between January and March 2023	History of knee surgery or trauma. Use of oral chondroprotectors in the past year. Having received corticosteroid injections in the past year. Having undergone viscosupplementation in the past year	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:21
RBR-109zgrk9	How intra-workout Caffeine Gel Supplementation impacts cycling performance	Data analysis completed	Intervention	2025-11-24	<NULL>	<NULL>	8571	Effects of intra-workout Gel Caffeine Supplementation on the modulation of the autonomic nervous system autonomic nervous system and intermittent sprint performance in cyclists	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-02	Universidade Federal do Rio de Janeiro (UFRJ)	<NULL>	<NULL>	<NULL>	Male sex; age between 25 and 45 years; at least four years of regular cycling practice; no current use of medications that interact with caffeine; and absence of medical conditions, including cardiovascular, gastrointestinal, musculoskeletal or metabolic disorders in the previous three months	Individuals diagnosed with gastritis; hypertension; allergy to supplement components such as flavorings or sweeteners; use of antidepressants or beta blockers; participants who did not correctly follow the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:50
RBR-85tmk64	Effect of homeopathic medicines for the treatment of Smoking	Data analysis completed	Intervention	2025-12-01	<NULL>	<NULL>	8601	Effect of Hetero-isotherapics for the treatment of Smoking	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2017-07-26	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Smoking participants; at least 18 years old; both sexes; who wish to give up the habit of smoking; participant must be a current smoker, which is someone who smokes daily or occasionally	Not be a smoker. Just be a passive smoker. Be an ex-smoker. Be under 18 years old. Participants who are included in the research, but refuse to adequately respond to the Follow-up questionnaire or do not attend monthly evaluation meetings with the team. People who have not smoked for at least 1 month (ex-smokers) or who do not smoke or who are passive smokers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-42nwshv	Auditory skills in schoolchildren and their impact on learning	Data analysis completed	Intervention	2025-12-03	<NULL>	<NULL>	8611	Effects of Neuroauditory Stimulation (SENA), Visuomotor Stimulation, and Acoustically Controlled Auditory Training on Central Auditory and Visual Processing in schoolchildren	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade Federal de São Paulo, UNIFESP	<NULL>	<NULL>	<NULL>	Present the signed informed consent and assent forms; Be between 8 years and 11 years and 11 months of age, male or female; Report complaints of learning difficulties; Have hearing thresholds up to 15 dB HL; Show alterations in Auditory Processing and visual perception assessments	Evidence of neuropsychiatric conditions that prevent the performance of the selected procedures; Lack of availability to attend the intervention sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3337xv9	Effect of Hippotherapy on biopsychomotor and functional skills in children and adolescents with Autism Spectrum Disorder: a cohort study	Data analysis completed	Observational	2025-12-04	<NULL>	<NULL>	8618	Equine therapy in Brazil: an epidemiological survey and its contributions to Autism Spectrum Disorder.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Campina Grande (UFCG), Centro de Tecnologia e Saúde Rural, Programa de Pós-Graduação em Ciência e Saúde Animal (PPGCSA).	<NULL>	<NULL>	<NULL>	Children and adolescents with a primary diagnosis or clinical history of ASD (Autism Spectrum Disorder); aged between 2 and 18 years; able to understand simple instructions; available to participate in the equine therapy program once a week.	Participation in other research related to horses; prior experience with equine therapy; presence of other neurological, psychiatric, or genetic diagnoses, such as comorbidities or disorders secondary to ASD (Down syndrome with ASD, bipolar disorder or schizophrenia associated with ASD and/or cerebral palsy with clinical signs of ASD); and lack of authorization from the medical or multidisciplinary team to perform equine therapy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-9bqqpc8	Effects of Erbium Laser on Facial Rejuvenation	Data analysis completed	Intervention	2025-12-05	<NULL>	<NULL>	8622	Effect of Er:YAG laser on labial and buccal mucosa	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	<NULL>	<NULL>	<NULL>	Males and females aged 35 to 70 years; in good general health; willing to adhere to the study protocol; presenting a chief complaint of aesthetic dissatisfaction with their lips; and pronounced nasolabial folds	Previous application of fillers or botulinum toxin in the region at any given moment; the possibility and/or presence of pregnancy; active oncologic treatment; and other conditions that lead to alterations in circulatory and or metabolic systems	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-2bmnfbn	The use of aromatherapy to manage anxiety in the nursing staff	Data analysis completed	Intervention	2025-12-09	<NULL>	<NULL>	8633	Aromatherapy in the management of anxiety in nursing professionals in a specialized service	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-02	Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	The study participants were nursing professionals who work with adolescents and who wished to participate voluntarily, with time available to participate in the sessions	Those who present with allergies or hypersensitivity to the materials used, who discontinue therapy, and/or who fail to attend sessions will not be considered for sampling purposes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-2h2pmbd	Supplementation with beneficial bacteria (Lactobacillus casei) to control blood sugar in people with obesity.	Data analysis completed	Intervention	2025-12-18	<NULL>	<NULL>	8665	Effect of Lactobacillus casei supplementation on the glycemic profile of obese patients: a randomized, double-blind, placebo-controlled clinical trial.	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-09	Fundação Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Adult patients up to 59 years of age, of both sexes, will be included; obese with a Body Mass Index (BMI) greater than or equal to 30 kilograms per square meter (kg/m²); followed by the Nutrition Clinic of the University Hospital of Aracaju/Sergipe	Patients who are pregnant; using corticosteroids, antimicrobials and/or prebiotic, probiotic or synbiotic supplements during the study; and who have a diagnosis of inflammatory bowel disease, celiac disease, lactose intolerance, or intestinal resections will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-6kj2h9d	Motivation and physical activity during ageing	Data analysis completed	Intervention	2025-12-18	<NULL>	<NULL>	8668	Motivational aspects for physical activity in the ageing process	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade do Oeste de Santa Catarina	<NULL>	<NULL>	<NULL>	Female sex; age equal to or older than sixty years; no prior participation in a structured exercise program; clinical fitness to participate in physical exercise as confirmed by medical clearance; understanding of and agreement with the study procedures; signing of the informed consent form	Failure to complete pre- or post-intervention assessments; lack of medical clearance for participation in physical exercise; presence of medical conditions that preclude participation in physical exercise; significant changes in dietary habits during the study period; withdrawal from the intervention program during the follow-up period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-66tbzr4	How teriparatide works in alveolar bone healing	Data analysis completed	Intervention	2025-12-23	<NULL>	<NULL>	8677	Understanding the effects of teriparatide on alveolar bone repair	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-05-04	Universidade Federal Fluminense	<NULL>	<NULL>	<NULL>	Individuals aged18 years or older; clinically healthy; with an indication for bilateral extraction of premolars and/or molars (from the same or different arches); with the presence of teeth adjacent to the teeth to be extracted and who agreed to participate in the study by signing the Informed Consent Form; Teeth with an indication for extraction without viability of rehabilitation	Presence of acute periapical or periodontal infection; serious systemic diseases; current use of medications such as chemotherapeutic agents, anticoagulants, corticosteroids, anti-resorptive agents (such as bisphosphonates and RANKL modulators) or immunosuppressants; decompensated chronic diseases (including hypertension, diabetes, rheumatological, renal or hepatic diseases); metabolic bone diseases (such as osteomalacia, hypocalcemia or hypercalcemia); motor limitations that compromise oral hygiene; active smoking (or ex-smokers with less than six months of cessation); pregnancy or history of radiotherapy in the last five years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10d8nkrv	Effects of Cryofrequency on Facial Rejuvenation	Data analysis completed	Intervention	2025-12-23	<NULL>	<NULL>	8680	Effects of Cryofrequency on the Treatment of Facial Skin Aging Signs	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-07	Universidade Estadual de Goiás	<NULL>	<NULL>	<NULL>	Women over 35 years of age; who present facial characteristics of aging such as fine dynamic and static wrinkles; sagging and loss of facial tone; who seek the services and aesthetics of the Aesthetics and Cosmetology course at the State University of Goiás and agree to participate in the study	Women who have undergone recent cosmetic treatment (within the previous 6 months); those with a history of abnormal scarring (keloid or hypertrophic scar); inflammatory skin disease; cardiovascular disease; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-29x7rhy	A comparative study between a modified traditional transscleral cyclophotocoagulation technique and the current standard technique in eyes with refractory glaucoma	Data analysis completed	Intervention	2025-12-24	<NULL>	<NULL>	8682	A prospective, randomized, comparative, examiner-masked study comparing a modification of the traditional transscleral cyclophotocoagulation technique with slow coagulation in eyes with refractory glaucoma	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; patients of any gender; patients who have undergone previous surgical interventions for glaucoma or not (excluding cyclodestructive procedures); patients previously operated on for glaucoma who experienced failure of such procedure(s) and did not achieve target intraocular pressure under maximally tolerated medication at medical discretion; patients with other subtypes of glaucoma classified as refractory glaucoma, such as neovascular glaucoma, glaucoma in aphakic eyes, inflammatory glaucoma, glaucoma associated with corneal transplant, post-vitreoretinal surgery glaucoma (with or without silicone oil implant), post-traumatic glaucoma; patients with glaucoma in eyes with conjunctiva unsuitable for filtering surgeries; patients with absolute glaucoma and a history of pain associated with marked ocular hypertension	Pregnant patients; lactating patients; patients with unknown or non-glaucoma related vision loss/deficit in any eye; history of previous cyclodestructive surgery; patients with a history of corneal refractive surgery; glaucoma with active uveitis; patient&apos;s inability to return on scheduled dates; patient&apos;s refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-6vtvdgy	Retrospective observational study of restorations supported by implants produced using 3D-printing technology	Data analysis completed	Observational	2026-01-05	<NULL>	<NULL>	8689	Retrospective observational study of implant-supported restorations using additively manufactured dental implants	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-03-13	Universidade de Guarulhos	<NULL>	<NULL>	<NULL>	Titanium implants manufactured by additive manufacturing (AM) by Plenum Bioengineering will be included in the study.	No exclusion criteria were applied for this study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-8ypr4kj	Acute neuromuscular fatigue responses to russian current in paralympic powerlifting athletes	Data analysis completed	Intervention	2026-01-05	<NULL>	<NULL>	8695	Analysis of training based on biochemical, hormonal, immunological, blood, hemodynamic, muscle architecture, and neuromuscular indicators in Paralympic powerlifting	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Departamento de Educação Física da Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Minimum of 18 months of experience in the sport; participation in at least one official competition of the Brazilian Paralympic Committee; ranking among the top 10 in their respective body weight categories	Volunteer with pain and/or injury; intolerance to electrostimulation; use of analgesics, tranquilizers, antidepressants or any centrally acting medication	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-857zyyw	Brain Stimulation with Light for Chronic Migraine	Data analysis completed	Intervention	2026-01-07	<NULL>	<NULL>	8704	Photobiomodulation by Transcranial Infrared Light Stimulation (FBM) in Chronic Common Migraine (CCM)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-23	Município Do Cabo de Santo Agostinho	<NULL>	<NULL>	<NULL>	Volunteers of both sexes aged between 18 and 90 years; with more than 15 migraine days per month; using migraine prophylaxis medication in the last three months	Patients under 18 years of age; pregnant women; epileptics; patients with sequelae of acute or subacute stroke; patients who abuse analgesic medications for headaches; patients with catamenial headache; patients with less than 15 days of pain per month	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-8n5ndqj	The effect of Cajuína consumption in untrained individuals	Data analysis completed	Intervention	2026-01-07	<NULL>	<NULL>	8707	The effects of Cajuína supplementation in individuals untrained subjects submitted to an Acute session of high intensity exercise: a randomized, double-blind follow-up of 72 hours	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-06	Universidade federal do ceará	<NULL>	<NULL>	<NULL>	Male individuals; age between 18 and 40 years; physically untrained; body mass between 60 and 100 kilograms; body mass index between 18.5 and 29.9 kilograms per square meter; absence of regular structured physical exercise in the last six months; Clinically healthy; no regular use of antioxidant supplements; no continuous use of medications; fit for intense physical exercise	Current smoking; regular consumption of alcoholic beverages; use of illicit drugs; prior diagnosis of cardiovascular metabolic neurologic musculoskeletal liver renal, hematological or respiratory diseases; history of food intolerance to the components of the intervention; use of drugs or supplements with potential antioxidant effect in the last three months; presence of musculoskeletal injuries that prevent intense physical exercise	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-6qvh3sf	Implementation of the sepsis protocol: a quasi-experimental study	Data analysis completed	Intervention	2026-01-13	<NULL>	<NULL>	8747	Implementation of the sepsis care pathway: an interventional pilot study.	<NULL>	n/a, single-arm-study, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-27	Hospital Universitário Gaffree e Guinle/HUGG/UNIRIO	<NULL>	<NULL>	<NULL>	Multidisciplinary healthcare professionals working in the medical clinic, of both sexes; nursing undergraduate students enrolled in the internship program (9th and 10th semesters); nursing and medical residents linked to the university hospital, who carry out their activities under the supervision of their respective preceptors and are able to initiate the protocol under supervision; protocols of patients aged 18 years or older, of both sexes, hospitalized in the medical clinic wards	Professionals who were on leave or vacation during the data collection period; professionals who did not attend the training day; protocols of patients admitted to the medical clinic with a previous diagnosis of sepsis; protocols previously opened in another hospital sector prior to admission to the medical clinic	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-43p8yst	Association between pain and inflammation after orthodontic elastomeric separation treated with Low-Level Laser Therapy and Cold Atmospheric Plasma: a randomized clinical trial	Data analysis completed	Intervention	2026-01-16	<NULL>	<NULL>	8768	Evaluation of pain parameters in orthodontic treatment under Cold Atmospheric Plasma application compared to Low-Level Laser Therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Centro Universitário da Fundação Herminio Ometto	<NULL>	<NULL>	<NULL>	Participants aged 18 to 25 years; in good general and oral health; with no previous orthodontic treatment; with no history of antibiotic, anti-inflammatory, or analgesic use in the month prior to or during the study; with complete permanent dentition; presenting malocclusions requiring orthodontic treatment; and with mesial and distal contact between the molars	Participants who report previous orthodontic treatment; who use a prosthesis or implant; who present any physical or intellectual condition that prevents subjective pain assessment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-10bg4v7f	Home blood pressure monitoring in individuals with difficult-to-control Hypertension: a randomized clinical trial	Data analysis completed	Intervention	2026-01-21	<NULL>	<NULL>	8785	Residential blood pressure monitoring in patients with uncontrolled Hypertension: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-12-12	Departamento de Enfermagem da Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Patients diagnosed with hypertension associated or not with Diabetes Mellitus; Coronary Artery Disease or Chronic Renal Failure; aged over 18 years; diagnosis time greater than 6 months; blood pressure greater than or equal to 140/90 mm Hg obtained during initial clinical consultation; be following the same antihypertensive medication treatment for at least 4 weeks; present mobility conditions to attend follow-up appointments at the health unit	Pregnant women; women actively seeking to become pregnant; those with physical and/or cognitive disabilities; those who have undergone surgical procedures, suffered accidents and/or amputations; those undergoing oncological treatment that makes it impossible to self-monitor blood pressure; inability to maintain the monitor at home represented by the participant&apos;s refusal to receive and keep the device; acute cardiovascular event in the last three months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-596mnj6	Retrospective cohort study for the validation of a predictive index of successful Hemodialysis discontinuation in patients with Acute Kidney Injury based on clinical variables	Data analysis completed	Observational	2026-01-26	<NULL>	<NULL>	8795	Clinical variables predicting successful discontinuation of Renal Replacement Therapy in hospitalized patients with Acute Kidney Injury – a retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Impar Serviços Hospitalares S/A	<NULL>	<NULL>	<NULL>	Patients with acute kidney injury requiring kidney replacement therapy	Pregnancy; kidney transplant; interruption of kidney replacement therapy due to hemodynamic instability, death or exclusive palliative care.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-10c878rd	Using an electric current in the brain to rehabilitate a patient with speech difficulties	Data analysis completed	Intervention	2026-01-27	<NULL>	<NULL>	8803	Use of Transcranial Direct Current Stimulation in the rehabilitation of patients with Aphasia	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Departamento de Fonoaudiologia - UFMG	<NULL>	<NULL>	<NULL>	Men and women; aged over 18. Native speakers of Brazilian Portuguese. Diagnosis of non-fluent aphasia resulting from a single episode of stroke in the left hemisphere. Premorbidly right-handed. Chronic phase of the lesion (&gt; 6 months). Performance below 70% in the task of oral naming of nouns and verbs	Previous diagnosis of communication, speech or language disorders prior to the current condition. Comorbidities involving the spinal cord. Psychiatric disorders. Uncontrolled seizures. Epilepsy. Increased intracranial pressure. Pregnancy. Use of a cochlear implant or implanted metallic material. Uncontrolled clinical comorbidities. Dependence on alcohol or chemical substances	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-9zmnvn6	Evaluation of the benefit of treating repetitive motion disorders in moderate to advanced dementia with the combined use of pramipexole and transcranial magnetic stimulation in elderly individuals	Data analysis completed	Intervention	2026-01-28	<NULL>	<NULL>	8809	Evaluation of the new applicability of the combined use of Pramipexole and Transcranial Magnetic Stimulation in Aberrant Motor Behavior in elderly people with moderate to advanced Dementia	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Elderly individuals; probable diagnosis of Alzheimer&apos;s disease; with aberrant motor behavior refractory to non-pharmacological measures	Use of implanted ferromagnetic devices; recent stroke; history of seizures; use of neuroleptics in the last 2 weeks; electrolyte disturbances; immobile; frail	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-9kjkfmf	Evaluation of the lowest effective dose of Anesthetic in a Nerve Block for pain control after Breast Surgery	Data analysis completed	Intervention	2026-01-30	<NULL>	<NULL>	8818	Evaluation of the minimum effective dose of Levobupivacaine in Serratus Anterior Plane Block for analgesia in patients undergoing Breast Surgery	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-10	Hospital do Câncer da Fundação Cristiano Varella	<NULL>	<NULL>	<NULL>	Female patients aged 18 to 75 years; American Society of Anesthesiologists (ASA) physical status I or II; indication for breast surgery (e.g., sectorectomy, quadrantectomy), with or without axillary approach; procedure performed under general anesthesia; eligible for ultrasound-guided serratus anterior plane block; ability to understand and respond to the numeric pain rating scale; and provision of written informed consent	Infection and/or local pain at the block site; allergy to any medication used during anesthesia; renal dysfunction; coagulopathy; body mass index (BMI) greater than 40 kg/m²; severe heart disease; inability or lack of understanding of the assessment tool; or refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-9qwz6r4	Study comparing the effectiveness of Tea Tree Oil and Chlorhexidine in reducing dental biofilm	Data analysis completed	Intervention	2026-02-05	<NULL>	<NULL>	8830	Comparative study of the effectiveness of Tea Tree Oil and Chlorhexidine in dental biofilm control: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Age equal to or over 18 years old; gingival bleeding within ten seconds after removing the probe from the gingival sulcus; presence of dental biofilm; tooth loss due to extraction for orthodontic treatment; both sexes	Smokers; alcoholics; diabetes mellitus; allergic to one of the study substances; use of orthodontic appliances; use of mouthwash or antimicrobial substance for at least two weeks before the start of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-23wvcfk	Effect of consuming foods with health-promoting properties on satiety, blood sugar and lipid levels	Data analysis completed	Intervention	2026-02-05	<NULL>	<NULL>	8833	Effect of functional foods and nutraceuticals on satiety, glycemic control, and lipid profile	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Individuals aged 20 to 50 years; both sexes; diagnosed with type 2 diabetes mellitus; under medical supervision and using a stable dose of oral hypoglycemic agents for at least six months	Pregnant women; individuals with dietary restrictions or participants in dietary restriction programs; individuals with autoimmune diseases, hepatic or renal diseases, or infectious diseases; individuals with food allergies; use of anti-inflammatory drugs, antibiotics, immunosuppressive agents, or nutritional supplements; chronic alcohol users; failure to complete all study assessments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-8d2kp7r	How home-based physical exercises can improve the health and quality of life of frail older adults in Belo Horizonte	Data analysis completed	Intervention	2026-02-09	<NULL>	<NULL>	8842	Effects of Physical Exercise on the experience of older adults in Belo Horizonte at risk and in a situation of Frailty	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Secretaria Municipal de Saúde de Belo Horizonte (SMSA-BH)	<NULL>	<NULL>	<NULL>	Age 60 years or older; the presence of established clinical frailty, as determined by a multidimensional assessment conducted by the research team.	Severe or decompensated clinical comorbidities; advanced cognitive impairment that would prevent them from understanding or performing the proposed intervention; immobility, defined as complete dependence on assistance for ambulation; or absence of a minimum level of family support necessary for participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-489jwz6	Simulation-based skills training through deliberate practice for medical students: a comparison between student instructor and expert instructor	Data analysis completed	Intervention	2026-02-10	<NULL>	<NULL>	8853	Skills simulated through deliberate practice among medical students: peer-assisted learning vs. learning with experts	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-07	Universidade de São Paulo - Faculdade de Odontologia de Bauru	<NULL>	<NULL>	<NULL>	men and women; second and third year undergraduate medical students; over 18 years old; had not previously received theoretical or practical training in urinary catheterization	had prior training in urinary catheter insertion; under 18 years old; were already serving as monitors at the Simulation &amp; Skills Laboratory	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5rysw9w	Cerebral versus muscles adaptations promoted by two respiratory training programs in endurance–trained individuals	Data analysis completed	Intervention	2026-02-10	<NULL>	<NULL>	8855	Cerebral versus muscles adaptations promoted by two respiratory training programs in endurance–trained individuals	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Pontificia Universidad Católica do Chile	<NULL>	<NULL>	<NULL>	Age 19 to 45 years; body mass index less than 25;  absence of chronic disease or musculoskeletal injuries within the previous three months prior to enrollment; engagement in regular endurance training (at least 3 sessions per week, 30min or more per session) for at least six months prior to enrollment	Use of any legal or illegal performance–enhancing substances; acute infections or inflammatory processes within two weeks prior to initial testing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-23pfcg5	Use of Zolpidem to help patients with fear of magnetic resonance imaging compared to traditional sedation	Data analysis completed	Intervention	2026-02-11	<NULL>	<NULL>	8863	Zolpidem in the management of claustrophobia during magnetic resonance imaging: a non-inferiority study compared to conventional sedation	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-03	Universidade de Sorocaba	<NULL>	<NULL>	<NULL>	Individuals referred to the IDS group for magnetic resonance imaging studies under sedation between July 3, 2023, and August 3, 2024; individuals who report claustrophobia at the time of exam scheduling; age older than 18 years and younger than 70 years.	Individuals who do not provide written informed consent; individuals who do not meet the inclusion criteria; individuals with absolute contraindications to zolpidem use, including hepatic impairment, renal impairment, severe pulmonary diseases, pregnancy, or breastfeeding; age younger than 18 years or older than 70 years; current or chronic use of Zolpidem.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-23chpws	Comparison between two types of medications for pain and swelling control after wisdom teeth removal	Data analysis completed	Intervention	2026-02-11	<NULL>	<NULL>	8864	Evaluation of two drug regimens in the levels of PGE2 after surgical extraction of third molars	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Odontologia de Piracicaba – Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18 and 30 years; ASA I (American Society of Anesthesiologists physical status classification I); Presence of mandibular third molars in similar positions; Not using any medication routinely or within the week prior to the study; No known allergy to the drugs used in the study; Surgical site without current signs or symptoms of infection.	Patients with a history of pregnancy or lactation; History of gastrointestinal bleeding or peptic ulcer; Allergy to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs); Patients under continuous use of psychoactive drugs, analgesics, or steroidal and nonsteroidal anti-inflammatory agents; Smokers; Presence of postoperative infection signs or symptoms.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-9vr6jyf	Effects of an accessible, low-cost, and individualized physical exercise program on the mobility of people with Mucopolysaccharidosis	Data analysis completed	Intervention	2026-02-26	<NULL>	<NULL>	8899	Impact of an accessible, low-cost, and individualized fhysical rehabilitation program on the functional capacity of patients with Mucopolysaccharidosis	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-05	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Individuals with a confirmed diagnosis of Mucopolysaccharidosis (any type) by enzyme assay and/or genotyping; of both sexes; over six years of age; whose guardians signed the informed consent form; under follow-up at the Reference Center for Inborn Errors of Metabolism; and without participation in physical rehabilitation or regular aerobic exercise (greater than 150 minutes/week) in the last six months	Patients unable to walk; with tracheostomies and/or dependent on invasive mechanical ventilation; hospitalized for acute respiratory infection less than 30 days prior to assessment; with severe heart disease; with cognitive impairment, unable to understand verbal instructions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:56
RBR-6jgjygt	Use of ozone and laser to reduce pain after root canal treatment: a clinical study.	Data analysis completed	Intervention	2026-02-25	<NULL>	<NULL>	8904	Effect of ozone therapy and laser therapy on postoperative discomfort in endodontic treatment: a clinical study.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-10	centro de pesquisa odontologica são leopoldo mandic	<NULL>	<NULL>	<NULL>	Adult participants over 18 years of age, of both sexes and regardless of origin or social class, who attend an endodontic clinic requiring endodontic treatment or retreatment and who have agreed to participate in the research will be included. All participants will sign the informed consent form	Participants will be excluded if they have systemic problems; periodontal problems; are wearing orthodontic appliances; have psychiatric disorders; have serious heart problems; are using topical or systemic; medications and muscle relaxants; anti-inflammatories and,or analgesics; and are pregnant	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-6g5ys67	Effects of consuming orange juice with a high-fat meal on metabolism	Data analysis completed	Intervention	2026-02-25	<NULL>	<NULL>	8906	Effects of orange flavonoid intake associated with a high-fat meal and their impact on advanced glycation end products (AGEs) concentrations	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18 and 30 years; no diagnosed illnesses; not using any medication; not vegan or vegetarian; and no smoking habits.	Smokers; individuals with chronic non-communicable diseases; obese individuals (BMI greater than or equal to 30 kg/m2); individuals with cardiovascular disease and kidney disease; vegetarians/vegans; and breastfeeding mothers.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-8h8hbtx	Muscle strength and an immediate energy boost with coffee	Data analysis completed	Intervention	2026-02-25	<NULL>	<NULL>	8907	Muscle strength and acute caffeine supplementation	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade de Brasilia	<NULL>	<NULL>	<NULL>	Young men (18 to 30 years old); At least six months of experience in strength training; Be healthy, especially considering cardiovascular and metabolic aspects; Not have any type of injury or joint, muscle, or bone problem that affects the knee extension exercise; Not report increased sensitivity or allergy to caffeine; Not be using anabolic steroids; Not be using supplements containing caffeine for at least one week; Be familiar with the squat exercise; Not be a smoker	Failure to complete all scheduled sessions; Performing resistance exercises, cyclic exercises, or any other type of exercise for the lower limbs during the experimental period that may affect the participant&apos;s performance during the tests; Using ergogenic substances other than those prescribed during the study period; Consuming additional caffeine not planned during the experimental period that may affect the test results	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-5mcym7y	Subcutaneous irrigation with 2% aqueous chlorhexidine vs. 0.9% saline solution in open bariatric surgery: randomized controlled trial.	Data analysis completed	Intervention	2026-02-27	<NULL>	<NULL>	8924	Intraoperative subcutaneous irrigation with 2% aqueous chlorhexidine vs. 0.9% saline solution and surgical wound infection rate in open bariatric bypass surgery: a prospective randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Irmandade da Santa Casa de Misericordia de Curitiba	<NULL>	<NULL>	<NULL>	Paciente who have undergone open bariatric bypass surgery; patients &gt;= 18 years old and &lt;=65 years old; both sexes (female and male)	Patients allergic to chlorhexidine; videolaparoscopic bariatric surgery; sleeve gastrectomy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-8qf7srs	Oral use of Oats in humans	Data analysis completed	Intervention	2026-03-03	<NULL>	<NULL>	8931	The use of oat Beta-Glucan as a bioactive agent in the treatment of Dyslipidemias	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Collaborating individuals from the Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ); who are between 18 and 50 years old; both sexes; those with dyslipidemia	Pregnant women; use cholesterol medications; who do not accept to participate in the research; who do not sign the Free and Informed Consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-5svckjw	Evaluation of the effects of Essential Oils on the reduction of Stress, Anxiety, and Insomnia and on Smoking Reduction among healthcare professionals	Data analysis completed	Intervention	2026-03-03	<NULL>	<NULL>	8935	Evaluation of the effectiveness of Aromatherapy in reducing levels of Stress, Anxiety, and Tobacco Use and in improving Sleep Quality among healthcare workers	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-15	Escola de Enfermagem da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Workers aged 18 years or older; of both sexes and different genders; who reported daily tobacco consumption for at least one year and who voluntarily agreed to participate in the study by providing written informed consent	Exclusion criteria comprised concurrent participation in another smoking cessation treatment; pregnancy; participants who entered medical leave or vacation during the study period and individuals with a diagnosis of asthma or severe allergic rhinitis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-37fzkwz	Probiotic supplementation improves gastrointestinal and psychological symptoms in stressed university students	Data analysis completed	Intervention	2026-03-05	<NULL>	<NULL>	8943	Intestinal modulation and its effects on gastrointestinal symptoms, the neuroendocrine system, and metabolic parameters in university students	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-10	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Undergraduate student ; self-reported stress; presence of gastrointestinal symptoms.	Current treatment for gastrointestinal symptoms (medications or probiotic supplements) or for anxiety/depression (antidepressants, anxiolytics, or antibiotics) within the past three months; any physical limitation or disability.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-32m7jn9	Development of Virtual Environment for Learning about Syphilis in Primary Care: Teaching Tool with Health Science Student	Data analysis completed	Intervention	2026-03-05	<NULL>	<NULL>	8947	Construction and validation of a Clinical Simulation scenario for teaching syphilis management in Primary Health Care: a teaching tool for undergraduate health students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Potiguar	<NULL>	<NULL>	<NULL>	To be a regularly enrolled nursing student between the 5th and 7th semester; have at least 75% attendance in the course	Absence from any stage of the intervention or from the application of the instruments; being a scholarship holder or a collaborator of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-4z5ndwm	Effects of breathing exercises and vocal training on the voices of amateur evangelical singers	Data analysis completed	Intervention	2026-03-12	<NULL>	<NULL>	8972	Effects of Vocal Training using voiced oral high-frequency oscillation with a respiratory device and Vocal Function Exercises in amateur evangelical singers	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Departamento de Fonoaudiologia da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Be between 18 and 45 years of age; have been singing in an evangelical church for at least one year; report good general health; both sexes.	Individuals with vocal complaints or vocal alterations identified during prior vocal screening; singers with cardiac or pulmonary conditions; smokers; self-reported hearing loss; neurological or psychiatric disorders; and scores higher than five on the Vocal Disorder Screening Index protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-4xz3q8w	Laser surgery or extracorporeal lithotripsy: which is the best for quality of life?	Data analysis completed	Intervention	2026-03-12	<NULL>	<NULL>	8973	Assessment of the impact on the quality of life of patients undergoing Ureteroscopy with Holmium laser compared to Extracorporeal shock wave lithotripsy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-11	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Symptomatic adults; over 18 years of age; ureterolithiasis confirmed by CT scan; stone`s maximum diameter between 5 and 20 millimeters	other urological conditions; pelvic pain syndrome; using anticholinergics; alpha-blockers; calcium channel antagonists; phosphodiesterase type 5 inhibitors; under 18 years of age; illiterate people; psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3jdsxsw	Transcranial Eectrical Stimulation, physical exercise, and craving in smokers	Data analysis completed	Intervention	2026-03-13	<NULL>	<NULL>	8974	Effects of Transcranial Direct Current Stimulation on craving in the prefrontal cortex before, during, and after physical exercise in smokers	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-03-14	Instituto de Ciências Biológicas e da Saúde da Universidade Federal de Alagoas	<NULL>	<NULL>	<NULL>	Age between 18 and 60 years; both sexes; being in stable clinical condition, without chronic obstructive pulmonary disease and without the need for hospital care; being on a waiting list for smoking cessation treatment centers in the city of Maceió, Brazil; intention to quit smoking; not participating in any type of smoking cessation treatment	Presence of chronic obstructive pulmonary disease; need for hospital care; unstable clinical conditions that prevent safe participation in aerobic exercise or transcranial direct current stimulation; current participation in any smoking cessation treatment; inability to understand or sign the Informed Consent Form; refusal to participate in the study or to continue at any stage of the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-6m954m4	From San Francisco to Rio: new approaches to HIV prevention for young men who have sex with men (Conectad@s Study)	Data analysis completed	Intervention	2026-03-13	<NULL>	<NULL>	8976	Collaborative research between San Francisco and Rio de Janeiro on HIV prevalence, risk, and biomedical prevention interventions among young men who have sex with men	<NULL>	4, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	Instituto Nacional de Infectologia Evandro Chagas - INI / FIOCRUZ	<NULL>	<NULL>	<NULL>	Male sex assigned at birth and male or non-binary gender identity or female sex assigned at birth and male gender identity; sex with men; age between 18 and 24 years; resident of the metropolitan region of Rio de Janeiro; with the intention of remaining in the region during the study; possession of a referral coupon (physical or electronic) from an eligible partner	Not agreeing to receive text messages; not owning a cell phone	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-7smyv87	Comparison of muscle strength and discomfort during electrical stimulation in healthy individuals, using self-adhesive electrodes and carbon–silicone electrodes.	Data analysis completed	Intervention	2026-03-21	<NULL>	<NULL>	8980	Comparison of peak torque and discomfort during neuromuscular electrical stimulation in healthy individuals using self-adhesive and carbon-silicone electrodes.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-24	Universidade São Francisco - USF	<NULL>	<NULL>	<NULL>	Women; healthy; aged between 18 and 30; with no history of nerve injury and/or musculoskeletal disorders in the limbs to be tested, which could interfere with the results.	Individuals using continuous pain-inhibiting medication; individuals with cardiac pacemakers; women who are pregnant, in the postpartum period, or menstruating; volunteers who, during the familiarization stimulation, cannot tolerate at least one contraction induced at 50% of their maximum voluntary isometric contraction force	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:23
RBR-742f68t	Electrical Stimulation and Voice: Immediate Effects in Women with Voice Disorders	Data analysis completed	Intervention	2026-03-19	<NULL>	<NULL>	9002	Comparison of the immediate effects of low-frequency and modulated medium-frequency TENS electrical currents on the self-perception and vocal quality of dysphonic women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Women with an otorhinolaryngological diagnosis of behavioral dysphonia, aged between 18 and 50 years. For the non-dysphonic group, women with self-reported good health, without vocal complaints or alterations, aged between 18 and 50 years, will be included.	For both groups: pregnant women; individuals with self-reported health conditions such as cardiac, pulmonary, hearing, neurological, or psychiatric disorders, or a diagnosis of organic dysphonia; those who have previously undergone speech-language therapy for voice; and those who have previously received electrotherapy for any type of treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-9rhyqy4	How can a jump training program in Pilates benefit elderly people?	Data analysis completed	Intervention	2026-03-26	<NULL>	<NULL>	9015	Analysis of the Jump Exercise on the Pilates Reformer Apparatus	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade do Estado de Santa Catarina	<NULL>	<NULL>	<NULL>	Adults aged 60 years or older; Both sexes; Previous participation in Pilates classes for at least six months with a frequency of two or more sessions per week; availability to attend the 12 intervention sessions during the study period; signed informed consent form	Severe cognitive impairment; cardiovascular or respiratory disorders; hypertension; history of musculoskeletal or joint injuries and/or bone fractures in the lower limbs in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-9syxzh3	Effect of Transcranial Electrical Stimulation and Intensive Physical Therapy in Cerebral Palsy	Data analysis completed	Intervention	2026-03-27	<NULL>	<NULL>	9024	Effect of Transcranial Direct Current Stimulation and Intensive Physical Therapy in Spastic Diparetic Cerebral Palsy	<NULL>	n/a, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-10	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Adolescent diagnosed with spastic diparetic cerebral palsy; ability to understand and follow simple instructions; availability to participate in all intervention and assessment sessions; absence of medical contraindications for undergoing transcranial direct current stimulation.	Presence of other neurological conditions that may affect the evaluation of results; presence of metallic implants or electrical devices in the skull that may interfere with the use of tDCS; history of uncontrolled seizures.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-976s5yy	The effect of vitamin C and D supplementation on immunity and performance in marathon runners	Data analysis completed	Intervention	2026-03-31	<NULL>	<NULL>	9044	The effect of vitamin C and D supplementation on the immunity and performance of amateur marathon runners	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-14	Programa de pós-graduação em Educação Física	<NULL>	<NULL>	<NULL>	Runners; male gender; marathon or ultramarathon runners for at least 3 years; aged between 20 and 45 years; training frequency of 3 days per week; average pace of 5:00 to 5:50 km/min in the last half marathon completed; no reported injuries in the last 6 months	Participants who are taking any other vitamin C and D supplements; have not completed a nutritional recall; or have completed a run longer than 5 km in the two days preceding the 42 km race will not be eligible	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-786s55w	Impact of herbal blend on amateur runners: hidden clinical study	Data analysis completed	Intervention	2026-04-02	<NULL>	<NULL>	9052	Effects of acute supplementation with Alpinia galanga and maca root on markers of athletic performance in amateur runners: a randomized, double-blind, crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-07	União Brasileira de Educação e Assistência	<NULL>	<NULL>	<NULL>	amateur runners of both sexes; aged between eighteen and fortyfive years; who have been training for running for at least six months; and who engage in at least one hundred and fifty minutes of physical activity per week	individuals diagnosed with any chronic disease or condition such as hypertension; type one or type two diabetes mellitus; as well as those using dietary supplements or medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-10vpw4bv	Physical therapy exercises to improve pain, quality of life, and physical capacity in Cancer patients receiving Palliative Care	Data analysis completed	Intervention	2026-04-09	<NULL>	<NULL>	9078	Analysis of the influence of Physiotherapy Exercise on pain, quality of life, and functional capacity of Cancer patients undergoing Palliative Care	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Fundação Doutor Amaral Carvalho	<NULL>	<NULL>	<NULL>	Patients aged 60 or older with a diagnosis requiring exclusive Palliative Care, meaning those who will no longer receive any invasive or life-prolonging interventions; Patients with intact neurological function who are able to respond to commands and answer requested questionnaires; Patients who score between 1, 2, or 3 on the ECOG scale (where 1 – presents symptoms of the disease but is ambulatory and leads a normal day; 2 – Out of bed more than 50% of the time; and 3 – In bed more than 50% of the time) and score between 30% (Very disabled; requires hospitalization and active supportive treatment) and 70% (Able to care for oneself; unable to carry out normal activities or perform active work) on the Karnofsky Scale (performs transfers to a chair) to 7 (static gait with or without assistance); Patients with a score of 3 (performs transfers to a chair) to 7 (static gait with or without assistance) on the ICU Mobility Scale; Patients with a score on the Visual Analogue Scale. (EVA) from 3 (mild moderate pain) to 7 (intense moderate pain); Patients who report a score of 0 to 7 on the Borg Scale; 8. Patients who remain hospitalized for at least 7 days.	Patients who remain hospitalized for less than 7 days; Patients who develop a need for palliative sedation during the evaluation, intervention, or re-evaluation period; Medical advice for absolute bed rest; Intense ventilatory discomfort that makes it impossible to carry out the exercise program; 5. Death during the 7-day period in which the evaluation and intervention will be carried out.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-2jyc55x	Effect of combined Training with Noninvasive Brain Stimulation on physical and motor performance in Athletes, Adults, and Older People with and without Parkinson Disease	Data analysis completed	Intervention	2026-04-10	<NULL>	<NULL>	9083	Effects of Mixed-Mode Training associated with Transcranial Direct Current Stimulation on physical and motor performance in Athletes, Healthy Adults, and Older Adults with and without Parkinson’s Disease	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-11	Universidade Anhembi Morumbi	<NULL>	<NULL>	<NULL>	Healthy adults and Olympic weightlifting athletes; older adults aged 50 years or older; older adults diagnosed with Parkinson’s disease by a specialist physician in a non-advanced stage and in the ON phase of medication; participants of both sexes	Individuals with orthopedic deformities; other neurological diseases; presence of metal in the head, surgical clips or metallic plates; implanted devices such as pacemakers, deep brain stimulation or cochlear implants; need for assistive devices for locomotion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-2ttqd58	Evaluating Knee Function and Recovery in Patients After Anterior Cruciate LigamentL Reconstruction	Data analysis completed	Intervention	2026-04-14	<NULL>	<NULL>	9099	Functional Analysis of Patients Undergoing Anterior Cruciate Ligament Reconstruction	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Age between 16 and 40 years; both sexes; patients from the Knee Surgery outpatient clinic at Hospital Universitário da Universidade Federal de Juiz de Fora; indication for elective knee surgeries (ligament or meniscal repair).	Presence of concomitant pathologies (previous muscle alterations, morbid obesity, or autoimmune diseases); cardiovascular or metabolic diseases; smoking; use of illicit drugs or anabolic steroids; use of supplements that accelerate metabolism or affect vascular dilation; indication for total or partial knee arthroplasty.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-10dxkjkr	Remote workshops for cognitive stimulation in the elderly.	Data analysis completed	Intervention	2026-04-24	<NULL>	<NULL>	9134	Teleworkshops for cognitive stimulation in the elderly: an experimental study	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-06	Hospital Universitário Gaffree e Guinle - Universidade Federal do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Seniors aged 60 or older; both sexes; registered in the Renascer program; with access to and basic proficiency in the use of Information and Communication Technologies (ICT); with preserved functional and cognitive capacity to moderate cognitive impairment; capable of performing instrumental activities of daily living with a minimum of 2 points on the Telephone item in the Instrumental Activities of Daily Living (IADL) scale; and capable of viewing and responding to text messages and interacting with the group	Elderly individuals with hearing loss or uncompensated visual impairment; a score of 7 or lower on the Instrumental Activities of Daily Living (IADL) scale; with progressive cognitive impairment, such as a medical diagnosis of dementia; for discontinuation criteria, a minimum participation of 50% in activities, both online and by performing activities individually at a time convenient for the participant	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-32q9fnd	Therapeutic effect of an adhesive on oral ulcers: a randomized clinical trial	Data analysis completed	Intervention	2026-05-05	<NULL>	<NULL>	9167	Efficacy of a therapeutic adhesive in traumatic oral ulcers: a randomized clinical trial	<NULL>	3, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	CCS - Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Patients aged 5 years, any genders or older treated at the State University of Maringá dental clinic; walk in patients or those from partner private clinics; individuals presenting painful symptoms associated with oral ulcers; clinical diagnosis confirmed by the principal investigator; patients willing and able to comply with all aspects of the study protocol; voluntary signing of the informed consent form, and for patients under 18 years of age, the form must be signed by a legal guardian	Patients with systemic diseases presenting oral manifestations in the form of ulcers; diabetic patients; pregnant women; children under 5 years of age; patients with oral infections of fungal, viral, or bacterial origin; individuals allergic to any component of the products used; patients using medications for the treatment of ulcers at the time of inclusion; patients using ill-fitting prostheses; presence of restorations with sharp edges; orthodontic appliance users; presence of any local interfering factor capable of causing chronic lesions; participants who used analgesics during the study were also excluded at a later stage	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-94bknr7	Using Puppet Theater to encourage preschool children to eat more fruits and vegetables	Data analysis completed	Intervention	2026-05-07	<NULL>	<NULL>	9177	The influence of Audiovisual stimuli on children’s eating habits	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade Federal de Lavras (UFLA)	<NULL>	<NULL>	<NULL>	The study included children aged 2 to 6 years; of pre-school age; of both sexes; with the requirement that their legal guardians sign a consent form authorising the child’s participation in the study	Children outside the 2–6 age group; and where participation was not authorised by the child’s legal guardians	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-4y59tq	Effect of the Informative Paper on patients and families in a Oncogenetic Ambulatory :evaluation of information and perception of coercion.	not yet recruiting	Intervention	2011-06-30	<NULL>	<NULL>	9	Randomized, double-blind study on the effect of the Informative Paper on patients and families in the Oncogenetic Ambulatory of universitary hospital: evaluation of information and perception of coercion.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital de Clínicas de Porto Alegre	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4y59tq	<NULL>	Will be included all adult patients who receive a positive diagnosis at the Ambulatory of Oncogenetics/Medical Genetics Service of the hospital for six months and agree to participate in the research, documented by the Consent Term. Also included are all adult family members who seek care at the same ambulatory for a fixed period and accept to participate in the research, documenting the acceptance by Consent Term.	Will be excluded under 18 years old,those who do not accept and  those familiaries who attend the institution after the deadline.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-3ypm3f	Effects of mild versus moderate training in patients with heart failure.	not yet recruiting	Intervention	2011-07-18	<NULL>	<NULL>	17	Comparison of the effects of mild versus moderate aerobic training on the inflammatory markers, on oxidative stress and quality of life, in patients with chronic heart failure – a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-09-01	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG	Ambulatório de Insuficiência Cardíaca - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-3ypm3f	<NULL>	"Patients with diagnosis of heart failure for at least six months, clinically stable for at least two months before this study. 
Left ventricular ejection fraction &lt; 45%.
Aging between 25 and 59 years old.
Body mass index (BMI) &lt; 30 kg/m2.
Stage C of the guidelines from the American College of Cardiology and American Heart Association (2005).
Classes I to III from the New York Heart Association (NYHA).
Sedentary, as defined by American College of Sports Medicine (2007)."	"User of cardiac pacemaker.
Inflammatory diseases in acute phase;
Renal insufficiency.
Orthopedic or neurological impairments which limit the exercise performance.
History of respiratory disease, unstable angina, uncontrolled arrhythmias or peripheral obstructive arterial disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-6c3bvm	Physical therapy protocol on normal birth puerperium	not yet recruiting	Intervention	2011-09-01	<NULL>	<NULL>	21	Physical therapy protocol on normal birth puerperium	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6c3bvm	<NULL>	Being resident in the city of Ribeirao Preto,  housewife for at least six months, being between 20 and 35 years old, weight between 60 and 70 pounds in the puerperium, height between 146 and 160 centimeters, having had an adequate weight gain during pregnancy (7 to 12 pounds), primigravida, vaginal delivery without episiotomy with laceration until 1 degree, having at least 6 hours after delivery and a maximum of 24 hours on the first visit, present abdominal diastasis larger than 2 centimeters (in caliper) and want to participate in the research	Perineal laceration greater than or equal to grade 2, forceps delivery, episiotomy, cesarean birth, abdominal diastasis under two centimeters or any pathology that would contraindicate a physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2c236v	Lower third molar removal with 2% articaine.	not yet recruiting	Intervention	2011-09-01	<NULL>	<NULL>	22	"Evaluation of the anesthetic efficacy and
hemodynamic effects in the use of 2% and
4% articaine associated with 1:200,000
epinephrine in lower third molar removals."	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2c236v	<NULL>	"Precise indication of removal of the two
lower third molars in similar positions in the same volunteer, as observed on panoramic radiograph;
All patients will provide written informed
consent during the pretreatment screening period before any study procedures are performed. The patients will be randomly selected regarding gender. The minimum age for inclusion in the study will be 18 years old and the maximum 45 years old."	"Presence of systemic diseases;
Presence of local inflammation and/or
infection;
Any history of allergic reaction to local
anesthetics, gastrointestinal bleeding or
ulceration;
Cardiovascular and kidney diseases;
Asthma and allergy to aspirin, piroxicam or
any other non-steroidal antiinflammatory
drug;
Regular use of any non-steroidal
antiinflammatory drug, pregnancy or breast feeding."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2wjrp4	Evaluation of four types of therapies for the treatment of urogenital atrophy in postmenopausal women	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	45	Randomized controlled clinical trial, with topical use of estrogen,testosterone, polyacryli cacid and placebo in the treatment of urogenital atrophy in postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-02	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM Unicamp	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-2wjrp4	<NULL>	"Physiological menopause with amenorrhea over three years

FSH&gt; 30 IU

Aged over 40 years and less than 75 years.

Women are not on medication for hormonal treatment of menopausal symptoms in the last 6 months

Women who have mammography and Pap smear in the last 12 months with appropriate result

Women with symptoms of urogenital atrophy."	"The patient&apos;s explicit refusal to participate

Patient with bilateral oophorectomy

Patients with a BMI less than 18.5 kg / m² or greater than 30 kg / m²

Women who present contraindication  to the use of topical estrogen, as follows: Absolute (recent myocardial infarction, severe hypertension, diabetes mellitus is difficult to control, history of thromboembolic disease, recent Liver failure, or severe, or activity, prior breast cancer , Cancer of the endometrium prior mammary dysplasia with atypical hyperplasia, genital bleeding of unknown origin) or relative (family history of breast cancer, endometrial hyperplasia prior Cholelithiasis)

Women who have ulcerative colitis, Crohn&apos;s disease or diarrhea due to intestinal disease

Women who have positive serology for HIV, Hepatitis B and C

Patients on medication for depression or other psychiatric disorders"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-7gt9pb	Effects of electric stimulation cutaneous and vaginal in women with stress urinary lost	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	49	Comparison of the effects of intravaginal electrical stimulation and surface electrical stimulation in women with stress urinary incontinence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-20	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-7gt9pb	<NULL>	Women older than 50 years of age; Complaint of stress urinary incontinence; Never have undergone physical therapy for UI treatment.	Levels 3 or 4 pelvic prolapse; Urinary and vaginal infection; Cardiac pacemaker; Metallic implant in pelvis and femur;  Pelvic radiotherapy; Pregnancy; Surgery for urinary incontinence; Cognitive dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2g27zn	Effect of the physical training in community-dwelling older women: randomized clinical assay	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	51	Effectiveness of the training with isolated load, training with load associated with the aerobic and isolated aerobic training on the functional and muscular performance, on the plasmáticas concentrations of inflammatory mediators and on the satisfaction with the life in community-dwelling older women	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Centro Universitário de Belo Horizonte - Uni-BH	Centro Universitário de Belo Horizonte - Uni-BH	https://ensaiosclinicos.gov.br/rg/RBR-2g27zn	<NULL>	Aging, community-dwelderly women, without distinction of race and/or social class, with equal age or above of 65 years old.	Previously submitted the orthopeadic surgeries of the inferiors members and/or with history of fracture it less has of one year; those that will not be capable to walking without aid; carrying of neurological illnesses; that to present some type of inflammatory illness in the acute phase that they can intervene with the tests; neoplasia in the five previous years; that to use drugs with ample action on the immunological system; that to present detectable cognitivas alterations by means of Mini-Examination of the Mental State; that to carry through physical activity of regular form for more than two times in the week;  to make use of some type of canal choke of calciun (Ca++), inhibitors of the Converting Converting Enzyme of Angiotensina II (ECA) and use of estatinas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-9fwv27	Study of gait and balance of subjects suffering from diabetic foot complications.	not yet recruiting	Intervention	2012-01-04	<NULL>	<NULL>	58	Gait parameters, plantar pressures and body balance of diabetics with neuropathy and vasculopathy that use insoles	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-11-10	Faculdade de Ciência e Tecnologia - Universidade Estadual Paulista	Faculdade de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9fwv27	<NULL>	In the diabetic group, will need medical confirmation of diabetes mellitus, changes in the circulation and peripheral perfusion, detected respectively by the ankle/ brachial index and pulse oximetry, and diabetic neuropathy confirmed by insensitivity to the Semmes-Weinstein monofilament 10g and the scale for the diagnosis of diabetic distal polyneuropathy. For the control group, it is mandatory sensitivity to monofilament 2g, confirming the normality of somatosensory sensitivity of the feet.	Will be excluded from the study who were diagnosed with other neurological disease or neuropathic; to have visual impairment or vestibular important and uncorrected, inability to understand for testing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-32sctf	Effect of elastic bandage on swelling after ankle sprain	not yet recruiting	Intervention	2012-01-26	<NULL>	<NULL>	63	Effect of Kinesio Taping on swelling after ankle sprain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-32sctf	<NULL>	People aged 15 to 45 years with acute ankle sprain.	People who have vestibular disorders or previous neurological or musculoskeletal any change that interferes with or contra-indicate the measurement procedures of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7yxnmv	Effects of a technique applied by the hands of the therapist in the thoracic spine in patients with temporomandibular joint and cervical disorders	not yet recruiting	Intervention	2012-02-13	<NULL>	<NULL>	88	Effects of high thoracic spine manipulation on temporomandibular and cervical disorders	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-26	Universidade Metodista de Piracicaba	Delaine Rodrigues Bigaton	https://ensaiosclinicos.gov.br/rg/RBR-7yxnmv	<NULL>	"All volunteers must have:
Diagnosis of temporomandibular disorders (TMD) according to the RDC / TMD (Ia, Ib, IIa, IIb, IIc and IIIa);
Pain and / or fatigue in the masticatory muscles during functional activities for a minimum period of 3 months;
Neck pain for at least 3 months;
Diagnosed with cervical dysfunction according to the neck Disability Index (NDI);
Body Mass Index (BMI) less than 25;
Scores of pain in the masticatory muscles and cervical greater than 3 cm according to the VAS."	"Missing teeth;
Open bite;
Cross bite;
Complete dentures;
Partial systemic neuromuscular diseases;
History of trauma to the face and / or TMJ;
Joint dislocation;
In orthodontic treatment and / or medication actually affecting the musculoskeletal system (pain relievers anti-inflammatories and muscle relaxants);
Red flag as a sign of malignant, infectious or inflammatory disease that contraindicate the use of manual therapy;
Occurrence of cervical whiplash;
Previous surgery of the cervical spine;
Diagnosis of fibromyalgia;
Previous experience with management over the past two months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-42gkzt	Action of low power laser on pain and quality of life and sleep in patients with fibromyalgia	not yet recruiting	Intervention	2012-02-14	<NULL>	<NULL>	90	Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-42gkzt	<NULL>	"A clinical diagnosis of fibromyalgia based on American College of Rheumatology criteria;  
Cognitive level sufficient for understanding the procedures and following the instructions; 
Agreement to participate in the study and the signing of a statement of informed consent after receiving clarifications regarding the objectives of the study."	"Psychiatric disorders, history of drug abuse or other behaviors that require intervention psychiatric medication;
 Development of uncontrolled clinical situations that prevent participation in aerobic activities, for efforts or group activities;
 History of epilepsy, seizures, heart disease and arrhythmias;
 A pacemaker;
 Presence of undiagnosed pain;
 Pregnant women;
 Patients with malignant tumors."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8m444q	Evaluation of anesthesia in cardiac surgery patients	not yet recruiting	Intervention	2012-03-09	<NULL>	<NULL>	91	Evaluation of the analgesic efficacy of general  and spinal anesthesia with morphine associated ropivacaine in patients who underwent surgery type coronary artery bypass grafting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-15	Universidade Federal do Rio Grande do Norte	Promater Hospital Geral	https://ensaiosclinicos.gov.br/rg/RBR-8m444q	<NULL>	"Assessment of the physical status;
Anesthetic risk classification according to the American Society of Anesthesiologists (ASA) ASA II and III;
The indication of coronary artery bypass grafting;
Verbal skills and understanding appropriate to participate in the interview; - No pain preoperatively."	"Manifestation of the patient and / or guardian&apos;s desire not to continue in the study;
Present severe postoperative complications such as respiratory and heart failure, valvular heart disease associated procedures and emergencies, reoperation;
Other disorders pre-operative treatment with heparin, since it may affect patients&apos; responses to questions about pain."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6d342s	Insoles for use of assistance for everyday tasks in children with cerebral palsy.	not yet recruiting	Intervention	2012-05-08	<NULL>	<NULL>	93	Insoles postural functionality of children with cerebral palsy randomized controlled trial.	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-05-15	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6d342s	<NULL>	To participate in the study, the children will be diagnosed with cerebral palsy, ranked among the levels of the GMFCS I and II and have to walk independently without the need for auxiliary resources (walker or crutches).	Children with CP who have undergone surgical procedures or the application of phenol in the last 12 months or neurolytic blocks in the last six months, children with cognitive and visual disabilities that may interfere with the performance of tasks, children with deformities of the ankle is not reducible to neutral and obese children.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-3wwt53	Effect of neural mobilization on the vertical jump and balance in healthy subjects	not yet recruiting	Intervention	2012-06-05	<NULL>	<NULL>	119	Effect of neural mobilization in the lower limbs on the vertical jump and balance in healthy subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-20	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3wwt53	<NULL>	Men and women, aged between 18 and 45 years, that do not have previous neurological or vestibular disorders, musculoskeletal or any change that interferes with or contra-indicate the measurement procedures of this study	Underage individuals and individuals with vestibular disorders, neurological or musculoskeletal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7yhr4w	Study of lung function, and sleep, and daytime sleepiness, and the behavior of the autonomic nervous system, and anxiety, depression, and stress in  chronic renal failure patients.	not yet recruiting	Intervention	2012-06-15	<NULL>	<NULL>	122	Study of lung function, and maximal ventilatory pressures, and sleep, and daytime sleepiness, and nocturnal periodic legs moviments, and autonomic nervous system activity, and ansiety, and depression, and stress vulnerability, in chronic kidney disease patients.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-02	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7yhr4w	<NULL>	"Patients with chronic renal failure candidates to  renal transplant with an indication of hemodialysis, that agree to participate in the study; 
Both gender;
Aged between 18 and 70 years;
Cognitive level sufficient for understanding the prodedures and fllowing the instructions."	Abuse of alcohol and or drugs;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-9vpm9c	Cooling as an adjuntive therapy to angioplasty in patients with myocardial infarction.	not yet recruiting	Intervention	2012-05-21	<NULL>	<NULL>	130	Cooling as an adjuntive therapy to percutaneous intervention in patients with acute myocardial infarction - &quot;cool-mi incor&quot; - version 2.0, february 2011.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	ZOLL CIRCULATION INC	ZOLL CIRCULATION INC	https://ensaiosclinicos.gov.br/rg/RBR-9vpm9c	<NULL>	Patients aged&gt; 18 years; The patient must have symptoms consistent with acute myocardial infarction (chest pain, or arm pain, etc.) and no improvement with nitroglycerin with onset of symptoms more than 30 minutes but less than six hours before its entry in the emergency room; Anterior wall AMI or less with ST segment elevation&gt; 1 mm in two or more contiguous leads; The patient must be eligible for the PCI; The expected time until the patients undergoing PCI should allow at least 30 minutes of cooling before PCI; The patient or legal guardian of the patient agrees and is willing to sign the informed consent to participate in the clinical study.	The patient had a previous myocardial infarction within one month; The patient has cardiogenic shock (systolic blood pressure (SBP) &lt;80 mmHg and unresponsive to volume or SBP &lt;100 mmHg with vasopressors, or need for an intra-aortic balloon - BIA); The patient has known hypersensitivity to hypothermia, including a history of Raynaud&apos;s disease; The patient has known hypersensitivity or contraindication to aspirin, heparin, or hypersensitivity to contrast that can not be adequately premedicated; The patient has known history of blood diathesis, coagulopathy, cryoglobulinemia or sickle cell anemia, or refuse a blood transfusion; The patient has a height &lt;1.5 m (4 feet 11 inches); The patient is known to be pregnant or expect to become pregnant before 1 month of follow-up; The patient has known hypersensitivity to buspirone or meperidine hydrochloride and / or treated with a monoamine oxidase inhibitor in the last 14 days; The patient has known history of hepatic or renal impairment, untreated hypothyroidism, Addison&apos;s disease, benign prostatic hypertrophy or urethral stricture, which in the opinion of the physician, would be incompatible with the administration of meperidine; To prevent nephrotoxicity gadolinium, patients with renal failure known as a set Glomerular Filtration Rate of less than 30 cubic centimeters per minute; Patients with vena cava filter; The patient has a life expectancy of pre-MI &lt;1 year due to underlying medical conditions or pre-existing comorbidities; The patient has known history of drug or alcohol addiction, or is unable to understand or follow the instructions; The patient is currently enrolled in the study COOL-MI or other drug research or study device that has not completed the primary endpoint or that clinically interferes with the outcomes of the COOL-MI study INCOR.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-44xmsx	Effects of the ultrasound therapy on venous ulcer healing	not yet recruiting	Intervention	2012-05-07	<NULL>	<NULL>	137	Effects of ultrasonic waves application on morphometric parameters and metalloproteases gene expression in venous ulcers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-07	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-44xmsx	<NULL>	"Unhealed venous ulcer with at least eight weeks of duration
Ankle-brachial index equal or higher than 0,8
Without signs of venous ulcer infecction
Without previous diagnosis of connective tissue disease that may interfere in the healing process
Without contraindication for ultrasound use"	"Wound infecction
Exclusion by patient request"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-6kvx74	Effect of drug therapy in the treatment of migraine	not yet recruiting	Observational	2012-04-26	<NULL>	<NULL>	138	Additional effect of physical therapy to drug treatment in reducing the intensity and frequency of migraine - a randomized controlled trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2011-11-01	Faculdade de Medicina de Ribeirão preto da Universidade de São Paulo	Departamento de Biomecânica Medicina e Reabilitação do Aparelho Locomotor.	https://ensaiosclinicos.gov.br/rg/RBR-6kvx74	<NULL>	Will be included 50 individuals with migraine, female, aged between 18 and 55. Will be considered only patients with at least two attacks and a maximum of 12 days of pain per month, with disease duration longer than one year, they are only in ambulatory treatment with amitriptyline up to 25 mg for at least 3 months.	Will be excluded women with diagnoses of other concurrent headache diagnosis of migraine, history of cervical trauma and face, with uncontrolled systemic diseases affecting the musculoskeletal system, peripheral nervous system diseases, which have physical therapy in the last one year specific to region or craniocervical posture and have some clinical contraindication to the use of amitriptyline as cardiac arrhythmias, glaucoma and epilepsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-55t5v9	Treatment of severe stroke guided by parameters regarding brain protection and neurological recovery	not yet recruiting	Observational	2012-05-01	<NULL>	<NULL>	140	Multimodal monitoring, inflammation and neuroregeneration in subarchnoid hemorrhage	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-55t5v9	<NULL>	Patients of 18 to 65 years of age; have been hospitalized at Clinical Hospital, University of São Paulo Medical School within the first 72 h after the first hemorrhage; presenting Hunt and Hess grade IV or V; presenting anterior circulation aneurysm.	Having undergone some neurosurgical procedure at another facility (e.g. placement of an external ventricular drain) before admission at Clinical Hospital, University of São Paulo Medical School; presenting severe systemic disease; presenting either a Glasgow coma scale score of 3 or pathological posture accompanied by bilateral mydriasis with fixed pupils; unavailable information regarding level of consciousness previously to sedation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-795k8m	Oral splint and counselling for the treatment of chronic facial pain	not yet recruiting	Intervention	2012-03-31	<NULL>	<NULL>	150	The efficacy of occlusal stabilization appliance associated to counselling in the management of myofascial pain chronic and in the improvement of the quality of life of patients with temporomandibular disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-05	Universidade Federal de Juiz de Fora	Patrícia Rocha Coelho	https://ensaiosclinicos.gov.br/rg/RBR-795k8m	<NULL>	"All subjects participated in this study volunteers by signing the consent form. Inclusion criteria are as follows:
female subjects;
aged 20 to 55 years;
irrespective of race, social status or religion;
presence of pain intensity of at least moderate (at least 4.0 on VAS), shown in the first clinical assessment;
diagnosis of myofascial pain persisting for a minimum period of six months."	"history of psychiatric disorders or treatment for neurological or psychological disorders;
volunteers with severe intellectual or physical disability that would hinder the collection of data;
history of systemic diseases that generate joint symptoms, muscle or rheumatologic, such as rheumatoid arthritis and fibromyalgia;
pain attributed to a well-defined local cause, such as pulpitis, trigeminal neuralgia and cancer pain;
attributable to migraine pain or infection;
report of any previous treatment for TMD;
treatment with drugs affecting the central nervous system (muscle relaxants, anticonvulsants, opioids, and antidepressants) and treatment with analgesics and anti-inflammatory drugs, with or without prescription, concomitant therapies to be instituted in this research;
report of facial trauma as a possible etiology of TMD;
subject denture wearers an upper or lower;
volunteers aged under 20 or over 55 years;
male individuals."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-2k3kbq	Comparison of the effectiveness of the use of pads in adult patients admitted to the Intensive Care Unit	not yet recruiting	Intervention	2012-03-07	<NULL>	<NULL>	156	Comparison of the effectiveness of the use of pads in adult patients with diagnoses of hyperthermia admitted to the Intensive Care Unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-01	Escola de Enfermagem Universidade Federal de Minas Gerais	Hospital Municipal Odilon Behrens	https://ensaiosclinicos.gov.br/rg/RBR-2k3kbq	<NULL>	"For inclusion of patients in this study will be established the following criteria: 
be over 18 years;
body temperature 38.3 ° C;
to consent to participate in the survey or have authorized their participation by signing the Statement of responsibility Consent"	"Exclusion criteria are: 
patient or guardian does not agree to sign the Instrument of Consent;
patients with severe heart disease, traumatic brain injury, malignant hyperthermia, pregnant women, which has a history of adverse reactions following the use of physical methods (hot or cold) in the reduction of body temperature and do not tolerate treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-3hkqg9	Reduction in blood pressure after cycle ergometer exercise and its physiological regulators: influence of time and association with hormone variation.	not yet recruiting	Intervention	2012-02-13	<NULL>	<NULL>	161	Post-Aerobic Exercise Hypotension and its Hemodynamic and Neural Mechanisms in Pre-Hypertensives: influence of time and association with circadian endocrine regulation.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-06-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratóio de Rins e Hormônios da Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3hkqg9	<NULL>	"Men
Aged between 20 and 40 years 
Systolic blood pressure between 120-139 mmHg and/or diastolic 80-89 mmHg
No diabetes
Sedentary or insufficiently active (did not perform physical activity more than twice a week)
Non smokers
Do not take any medicine that affects the cardiovascular system"	"Body Mass Index of equal to or greater than 30kg/m2
Subjects with cardiac diseases (previous diganosis or elatered rest or exercise ECG)
Individuals that are experiencing poor quality sleep (score greater than 5 at Pitsburg Sleep Quality Index)
- Not having chronotype intermediary, or be morning or evening"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-9k7s9j	Changes in Heart Rate and Benefits of an  Exercise Training Carried Out During Hemodialysis in Intensive Care Unit Patients (ICU)	Not yet recruiting	Intervention	2013-04-19	<NULL>	<NULL>	181	Hemodynamic Effects of Physical Activity in Critically Ill Patients During Hemodialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-05-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9k7s9j	<NULL>	Hemodynamical stability, hemoglobin &gt; 6 g/dl and lower limb problems that precluded exercise (for example leg bone tumor, deep vein thrombosis).	Catheter positioned in arterial femoral site.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-8jnxtm	Effects of music on cardiovascular system	Not yet recruiting	Intervention	2013-07-08	<NULL>	<NULL>	207	Effect of different hearing stimuli on cardiac autonomic regulation	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-30	Faculdade de Filosofia e Ciências, UNESP/Marília	Faculdade de Ciências e Tecnologia, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8jnxtm	<NULL>	Healthy subjects with no experience with classical dance and musical instrument lessons.	Disorders of auditory sensitivity, cardiorespiratory disorders, neurological and other impairments that prevent the subject known to perform procedures, treatment with drugs that influence cardiac autonomic regulation, practice-classical dance for at least one year, participation in classes of any musical instrument for at least one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-29gj42	Diabetes Management from Information Transmitted by Phone Calls	Not yet recruiting	Intervention	2013-07-17	<NULL>	<NULL>	216	Control of Type 2 Diabetes Mellitus: Analysis of an Intervention Program with Information about the Disease Via Phone Calls	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2013-09-09	Universidade Federal do Ceará - Departamento de Enfermagem	Universidade Federal do Ceará - Departamento de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-29gj42	<NULL>	Having type 2 diabetes for at least one year;Having more than 18 years old;Owning telephone contact;Being able to come to the unit for blood collection;Being able to self-monitoring of blood glucose and self-administration of medicines;Being able to understand the goals, methods and treatment procedures.	Owning hemoglonina glycated less than 7%;Have complications from the disease: kidney failure, blindness and amputation of limbs;Submit severe cardiovascular disease, high blood pressure or mental illness;Be participating in research with similar goals, made by other researchers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-7j5xyf	Adherence to physiotherapeutic orientation to practice pelvic floor muscle exercises in women with urinary incontinence	Not yet recruiting	Intervention	2013-08-07	<NULL>	<NULL>	222	Adherence to physiotherapeutic orientation to practice pelvic floor muscle exercises in women with urinary incontinence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7j5xyf	<NULL>	Women with symptoms consistent with urinary incontinence (stress, urge or mixed) and older than 18 years and less than 80 years old.	Exclusion criteria are: virginity, pregnancy, women with gynecological cancer or bladder cancer, women diagnosed with neurological diseases (stroke, multiple sclerosis, parkinsonism, epilepsy, tumor or spinal cord trauma), observed cognitive deficits  (minimental &lt;14), difficulties in performing activities of daily life, not agreeing to participate in the study by signing the consent of the ethics committee,those who can not contract adequately pelvic floor during pelvic floor muscle assessment and women who previously held treatment with  pelvic floor exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-4x2957	Study of the therapies for dentin hypersensitivity.	Not yet recruiting	Intervention	2013-08-13	<NULL>	<NULL>	227	Comparative study of therapies for the treatment of non-carious cervical lesions with dentinal hypersensitivity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-03-20	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4x2957	<NULL>	"The volunteers: they will be included with age 18 years or older,  enrolled in the clinics of dentistry UFPI having at least 20 dental elements.
Non-carious lesions: at least four lesions whose sensitivity is classified by the patient for moderate to severe after administration of a air, and tooth wear between 2 and 4. These teeth must have an antagonist tooth."	"The patient: will be excluded  people who have made periodontal treatment and/or hypersensitivity treatment in the last six months, patients with bruxism in the active phase.
Non-carious lesions: teeth with very deep lesions, when a ruber dam isolation is not possible and those that have been previously restored."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-7ddb5s	Evaluation of hormonal acne in adult women and its treatment with two different therapies.	Not yet recruiting	Intervention	2013-08-13	<NULL>	<NULL>	228	Contribution to the study of acne in adult women: analysis of the correlation between peripheral androgen conversion and its influence on the expression of toll-like receptors 2 and CD1d in areas with and without inflammatory acne lesions and its modulation by treatment with oral contraceptive or topical cream with anti-androgen activity.	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2012-03-01	UNIFESP-EPM	fleury laboratório	https://ensaiosclinicos.gov.br/rg/RBR-7ddb5s	<NULL>	"To all:

Signing the consent form before any study procedures;
women aged 26-44 years, not pregnant and in good health;
no topical treatment for acne in the last three months, except sanitizers;
Lack of use of oral antibiotics in the last 3 months;
Absence of the use of isotretinoin in the last two years;
Absence of oral contraceptive use in the last 3 months;
Absence of clinical evidence of immunosuppression and
accordance with the conditions of study, ability to understand and strictly follow the instructions received.

For the group treated with oral contraceptives:
Absence of contraindications to the use of hormonal contraceptives.

For the group treated with azelaic acid:
Absence of skin hypersensitivity to azelaic acid."	"Women who do not agree with the conditions of the study or without the ability to understand and strictly follow the advice they had received no willingness to attend the revaluations or refuse to sign the Informed Consent;
Pregnant or lactating women; 
Use the following oral medications: cortisone derivatives, lithium, anticonvulsants, isoniazid, oral contraceptives, androgens, danazol, iodides, bromides, disulfiram, cyclosporine, azathioprine, tiuréias, vitamins B2, B6 and B12;
Treatment of facial skin with topical retinoids (tretinoin and adapalene), azelaic acid, benzoyl peroxide, clindamycin, erythromycin, nicotinamina, singly or in combination, in the last 3 months;
Treatment with oral antibiotics in the last 3 months;
Use of cosmetics acnogênicos;
Presence of contraindications to oral contraceptive use (smoker over 35 years;
history of deep venous thrombosis, history of stroke, history of breast cancer, presence of jaundice, and severe active liver disease or biliary disease;
diabetes mellitus for more than 20 years or eye injury, neurological or renal arterial pressure greater than or equal to 160 to 100 for systolic and diastolic;
cardiovascular disease and the presence of severe headache associated with blurred vision often) for the group treated with oral contraceptive;
Presence of allergic symptoms and / or irritating to the use of azelaic acid for the group treated with azelaic acid;
History, clinical signs and / or laboratory hyperandrogenism prior to a control group;
Presence of inflammatory acne on the face for the control group 2."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-6jbpxc	Influence of education and home care in chronic muscle pain in the face	Not yet recruiting	Intervention	2013-10-16	<NULL>	<NULL>	257	Influence of education and self-care on pain and function related to chronic temporomandibular disorders: a randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-10	UNESP - Universidade Estadual Paulista / Faculdade de Odontologia de Araraquara	UNESP - Universidade Estadual Paulista / Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-6jbpxc	<NULL>	"Female gender
Aged between 18 and 70 years old
Chronic pain related to temporomandibular disorder
Do not be in treatment for this painful condition
Do not be starting any treatment for any other painful condition fibromyalgia, back pain, neck pain or rheumatic changes. If a medication has been using for 3 months or more, may be included in the sample.
Be able to read and write.
Do not present  problems in cognitive abilities or communication."	"Presence of acute TMD.
If the individual is starting treatment for any painful condition as fibromyalgia, back pain, neck pain, or rheumatic diseases.
Presence of cognitive or communication difficulties."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-7ckpdd	Study of sleep quality, the strength of the lungs, the strength of the muscles of breathing, closing of the throat, nervous system and quality of life in patients with Myasthenia Gravis	Not yet recruiting	Observational	2013-10-30	<NULL>	<NULL>	262	Evaluation of sleep, lung function, respiratory muscle strength, respiratory mechanics, collapsibility of the upper airway, autonomic nervous activity, and quality of life in patients with Myasthenia Gravis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7ckpdd	<NULL>	Patients diagnosed with Myasthenia Gravis, clinically stable, of both genders, aged between 18 and 65 years, who agree to participate in this study by signing the Instrument of Consent.	Patients who making use of abusive alcohol and or drugs and which is not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-8mf5x2	Clinical Trial comparative with and without use of Nimotuzumab for the treatment of Cervical Cancer with radiotherapy and Cisplatin	Not yet recruiting	Intervention	2014-01-15	<NULL>	<NULL>	270	A Phase III, Multicenter, Randomized, Two-arm Clinical Study: An Investigational Arm Containing Nimotuzumab in Combination with Radiation Therapy and Cisplatin, and A Control Arm with Radiation Therapy and Cisplatin for the Treatment of Stages IIb to IVa Uterine Cervical Carcinoma	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2014-01-02	Eurofarma Laboratórios S.A.	Eurofarma Laboratórios S.A.	https://ensaiosclinicos.gov.br/rg/RBR-8mf5x2	<NULL>	Be 18 years of age or older; have a histologically confirmed diagnosis of stage IIB to IVA squamous cell carcinoma, or adenocarcinoma, or cervical adenosquamous carcinoma, according to the IFGO system; life expectancy longer than 12 weeks; have measurable disease, according to the RECIST 1.1 criteria, or at least assessable by imaging and/or gynecological examination (imaging from up to six weeks prior to randomization will be accepted); indication for definitive treatment with chemotherapy and radiation therapy, according to the investigator’s opinion; performance status ? 2, according to the ECOG criteria; adequate bodily functions; have signed the informed consent form.	Involvement of para-aortic lymph nodes, by radiological and/or surgical staging, according to the investigator’s opinion; presence of severe co-morbidities, which –  according to the opinion of the investigator – will put the patient at a significantly higher risk or will impair compliance with the protocol; presence of neurological or psychiatric diseases or other significant conditions compromising compliance; known hypersensitivity or allergy to the study treatments; non-controlled hypercalcemia (&gt; 11.5 mg/dL, i.e., grade &gt; 1 according to CTCAE v4.02, of the American National Cancer Institute); known seropositivity to HIV; known and active hepatitis B or C; pregnant or lactating patients; patients – and their partners – refusing to use a proper contraceptive method during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-8kqqxh	Evaluation Forms of Anestesia for Human Reproduction	Not yet recruiting	Intervention	2014-02-10	<NULL>	<NULL>	276	Comparative Study Between Two Anesthetic Techniques For Follicular Puncture Guided By Transvaginal Ultrasound	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Faculdade de Medicina do ABC	Centro de Reprodução Humana e Genética da Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8kqqxh	<NULL>	Women with the presence of at least one follicle bigger than 14 millimeters, to be punctured; Aged between 20 to 40 years old; with a diagnosis of infertility patients who attempted to spontaneous pregnancy for at least 12 months with regular sexual activity and without the use of contraceptives, however, failed to achieve pregnancy; Body Mass Index (BMI) between 20 and 30; Surgical risk by American Society of Anesthesiologists (ASA) 1 or 2.	Incomplete medical records; Carriers of chromosomal diseases; donor oocytes; Pathologies associeted with surgical risk ASA III, IV, V and VI; Presence of known allergy to anesthethic drugs used in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-6tnw2b	Evaluation of G-CSF treatment of patients with chagasic cardiomyopathy.	Not yet recruiting	Intervention	2014-05-28	<NULL>	<NULL>	298	Phase II clinical trial, prospective, double-blind, randomized, placebo-controlled trial for the evaluation of G-CSF in patients with chronic Chagas cardiomyopathy	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-01-02	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6tnw2b	<NULL>	Diagnosis of Chagas&apos; disease confirmed by two serological tests with different methodologies; Diagnosis of Chagas&apos; cardiomyopathy in functional classes II, III and NYHA IV heart failure; Availability and willingness to participate, given the schedule of the study; Agreement and signing the consent form.	"-Acute systemic infections; Solid Malignancies, myelodysplasia, acute myeloid leukemia or chronic, confirmed by imaging studies or past medical history; Valvular with hemodynamic consequences; 
Autoimmune, pulmonary, or degenerative diseases, confirmed by imaging studies or past medical history; Renal dysfunction, severe liver or thyroid, confirmed by imaging studies or past medical history; 
Pregnancy (confirmed by examination of ? HCG) or lactation; Known hypersensitivity to G-CSF or to other components of the formula and / or hypersensitivity to proteins derived from E. coli."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-4w6v2c	Evaluation of the Impact of neuromodulators on urinary, intestinal and sexual functions and on spasticity in spinal cord injured individuals	Not yet recruiting	Intervention	2014-07-14	<NULL>	<NULL>	316	Impact of lumbosacral plexus stimulation by means of laparoscopically implanted eletrodes on urinary, intestinal and vasomotor functions and on lower limb and pelvic floor spasticity and sleep quality in spinal cord injured individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Hospital São Paulo - Hospital Universitário da Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4w6v2c	<NULL>	Individuals aging 18 to 60 years, with partial or complete spinal cord injury ASIA (American Spinal Injury Association) score A or B, in clean intermitent self-catheterization and/or with urinary incontinence and neurologically stable for more than one year.	"Subjects with the following characteristics will be excluded:  urodynamic bladder atonia; suspicion of vesicoureteral reflux prior to the spinal cord injury;	Diabetes Mellitus, compensated or not;	congenital or acquired immunodeficiency; known or suspected malignancy; history of rectossigmoidectomy, colectomy, or other gastrointestinal surgeries that can cause changes in bowel habits, stool anal continence or function; history of surgical treatment of uterovaginal prolapse, urinary incontinence, bladder augmentation procedures or other procedures associated with dysfunctional voiding (urethrotomy etc.); history of prostatectomy, transurethral resection of the prostate or prostatic other invasive procedures except biopsy; history of central or peripheral procedures neuroablative as rizotomy, cordotomy etc.;	uterovaginal prolapse, rectal or urethral;	cystostomy; anal or urethral stenosis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-9mtnvr	Influence of gymnastics classes on the development of balance control in elderly	Not yet recruiting	Intervention	2014-08-13	<NULL>	<NULL>	324	Gymnastics for All in postural balance in noninstitutionalized elderly: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-09-18	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9mtnvr	<NULL>	60-year and older age for both men and women, noninstitucionalized. 10 m of free walking without any auxiliary device. Low cardiovascular risk. Medical permission for participation in the study	Diagnosed psychiatric disease. Gait and balance dysfuntioc (Parkinson, Multiple Sclerosis,  stroke sequel, etc.). Use of meclizine hydrochloride. Severe respiratory insufficiency. Severe coronar arterial disease. Severe renal insufficiency. Severe hepatic insufficiency. Severe osteoporosis. With articular prosthesis and osteosynthesis material. Arterial pressure imbalance.  Dyslipidemc patients. Visual deficiency.  Uncontrolled diabetes. Labyrinthitis.  Minimental  score smaller than 24 points. Regular participation in an exercise program in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-459y54	Use of TENS for reducing pain after cesarean	Not yet recruiting	Intervention	2014-09-15	<NULL>	<NULL>	334	Effect of TENS in pain after cesarean	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-05	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-459y54	<NULL>	Women undergoing cesarean delivery with incisional pain intensity greater than three on a numeric scale with 15 years or more. Mothers who are in the period between eight and 12 hours postpartum. Physical status I or II, according to the American Society Anesthesiology. Absence of hearing impairment or visual communication, or even have no cognitive disorder / psychiatric impairment. These women should be admitted to the maternity João Firpo Hospital Santa Isabel (Aracaju / Se).	Women with some post-cesarean complications. Mothers with their newborns in the intensive care unit neonatal. Women who had prior use of Transcutaneous Electrical Nerve Stimulation. Those with contraindications to the use of Transcutaneous Electrical Nerve Stimulation. Mothers with an inability to understand the instructions or consent for the study. Women with hepatic impairment, renal or cardiovascular. Neurological disorders or lung disease. Heart disease. Women taking antidepressants. Use of psychoactive drugs or glucocorticosteroids in the week prior to the study. Use of pacemakers. Postpartum women with morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-4wkr8y	Influence of the practice of Pilates in the strength of the pelvic floor muscles on the loss of urine and back pain in the last trimester of pregnancy	Not yet recruiting	Intervention	2014-09-18	<NULL>	<NULL>	336	Clinical trial: influence of the practice of Pilates on the incidence of urinary incontinence, perineal strength low back pain in the third trimester	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Mariana Mara Buen	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4wkr8y	<NULL>	First pregnancy. Greater than 18. There have reports of urinary incontinence pre pregnancy and low back pain. Gestational age of 20 to 25 weeks. Pregnancy single fetus.	Women with neurological antecedents that caused cognitive deficit or lower limb motor. Women with physical and / or mental limitations for running exercises. Restrictive lung diseases. Heart Disease. Having performed regular physical exercise or Pilates in the past six months. Pre pregnancy Body Mass Index (BMI) &gt; or equal to 30.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-2sgtn2	Effectiveness of Pilates and ingestion of Green Tea in elderly patients who have Metabolic Syndrome	Not yet recruiting	Intervention	2015-01-12	<NULL>	<NULL>	368	Effectiveness of the Pilates method and the supplementation with Green Tea (Camelia Sinensis) in the biochemical, oxidative markers, antioxidant status levels and in gene expression in elderly patients with Metabolic Syndrome - clinical trial randomized double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-04-07	Pontifícia Universidade Católica do Rio Grande do Sul	Programa de Pós-Graduação em Gerontologia Biomédica do Instituto de Geriatria e Gerontologia da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-2sgtn2	<NULL>	Aged over 60 years; female; have metabolic syndrome.	Have cardiovascular disease; have liver disease; gastric disease; thyroid problems; memory problems; anxiety and sleep disorders;have physical problems that preclude training with pilates;have done in the past or is doing pilates or other form of physical exercise on a regular way; intake green tea by regular or habitual way.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5d98rs	Use of the device Magic Touch for the Treatment of Coronary Lesions	Not yet recruiting	Intervention	2015-02-03	<NULL>	<NULL>	381	Magic Touch	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Instituto Dante Pazzanese de Cardiologia	Hospital Bandeirantes	https://ensaiosclinicos.gov.br/rg/RBR-5d98rs	<NULL>	The patient must be more or equal 18 or less or equal 80 years of age; Symptomatic ischemic heart disease; Acceptable candidate for coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty ; The Patient is willing to comply with specified follow-up evaluations;  The Patient or legally authorized epresentative has been informed of the nature of the study, agrees to its provisions and has been provided written informed consent, approved by the appropriate Medical Ethics Committee (MEC), Institutional Review Board (IRB), or Human Research Ethics Committee (HREC);Patients with restenosis of native coronary artery previously stenting (BMS) (Cohort A) and patients with single de novo lesion not treated with stent in the target vessel (Cohort B); Patients with multivessel coronary artery disease may have been undergoing treatment successfully vessel with non-target devices approved up to and including the index procedure, but before the index treatment of the target vessel. Any vessel or target lesion not to be treated during the index procedure, can not be located in unprotected left main trunk, ostium, bifurcation or venous grafts or with chronic total occlusion (CTO), severe calcification or angiographic evidence of thrombus from somehow requires performing atherectomy or thrombectomy pretreatment techniques other than balloon angioplasty; Target lesion located in a native coronary artery; Target lesion 15mm in length by visual estimate (cohort A); The target lesion (maximum length of 20 mm by visual estimation) is covered by a single stent Cronus at most 23 mm long (Cohort B); The reference vessel diameter must be more or equal 3.0 or and less or equal 3.5 mm according to visual estimation. The vessel diameter should be measured after the procedure predilatation and after intracoronary administration of nitroglycerin on suspicion of spasm; Stenosis of the target lesion more or equal 50% and less than 100% according to visual estimation.	"Pregnant or lactating patients and are planning to become pregnant in the period of 1 year after the index procedure. Women of childbearing potential should have a negative result on a pregnancy test performed within 7 days before the 
index procedure; Patient with known diagnosis of acute myocardial infarction (AMI) within 72 hours prior to the index procedure (increased concentration of troponin or CKMB more or equal 2 times the upper limit of normal) or more than 72 hours prior to the index procedure and the absence of return of CK and CKMB to within normal limits at the time of the procedure; The patient has clinical symptoms consistent with new AMI, as prolonged chest pain not responsive to the administration of nitrate; Impaired renal function or patients on dialysis; Platelet count less than 100,000 cells/mm3 or more than 700,000 cells/mm3 or a WBC count less than 3,000 cells/mm3; 
Patient with a history of bleeding diathesis or coagulopathy or in which antiplatelet therapy and / or anticoagulant is contraindicated; Any patient undergoing organ transplant waiting list or to perform organ transplant; Patient with another disease or known substance abuse. History that can impair adherence to protocol, confound the interpretation of data or is associated with limited life expectancy; Patients with known hypersensitivity or contraindication aspirin, heparin / bivalirudin, clopidogrel / ticlopidine, prasugrel, cobalt and chromium, sirolimus and / or sensitivity to contrast that can not be adequately premedicated; Patient with cardiogenic shock; Patients with unstable cardiac arrhythmias causing hemodynamic instability; Patient with extensive peripheral vascular disease that prevents the insertion of 6 Fr sheath safely; Any significant disease that in the opinion of the investigator, may interfere with the patient&apos;s participation in the study; Current participation in another study of a drug or device or inclusion in another study of a drug or device during follow up; 

Angiographic exclusion criteria: 
Coronary artery disease in the left main trunk unprotected stenosis &gt; or =  50%; Ostial lesion; Total occlusion of the target vessel (TIMI flow 0); Lesion (s) calcified target (s) that can not (m) be submitted (s) to the pre-dilatation with success; Target lesion is inadequate to release excessive tortuosity and stenting; Angiographic evidence of thrombus in the target lesion; Target bifurcation lesion with lateral branch diameter &gt; or = 2.0 mm (either stenosis in the main vessel and the side branch greater or just the latter) that requires intervention on the affected side branch; Significant stenosis (&gt; 50%) proximal or distal to the target lesion can not be covered by the same stent; Diffuse disease distal to the target lesion with loss of flow; Ejection fraction of the left ventricle (LVEF) &lt; or = 30% (LVEF should be measured one month before the index procedure); Pretreatment with devices other than the balloon; Previous stent 10mm target lesion; Intervention (PCI or surgical) of another lesion performed within 6 months before or planned within 30 days after the index procedure."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5q5nz4	Effects of running technique modification	Not yet recruiting	Intervention	2015-02-23	<NULL>	<NULL>	400	Effects of Running Technique Modification on lower limb kinematics and muscle activation in runners with and without Patellofemoral Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-10	Universidade Federal de São Carlos/UFSCar	Universidade Federal de São Carlos/UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-5q5nz4	<NULL>	"Rearfoot strikers, familiar with treadmillrunning and run a minimum of 20 km/wk at least 3 months prior to study enrollment
All must have previous anterior or retropatellar pain in at least three of these activities: up/down stairs, squatting, running, kneeling, jumping and after seated for long periods; insidious onset of symptoms unrelated to traumatic incident and persistent for at least three months during the running activity; presence of pain after patellar compression and usual pain in the last week of at least 3 cm on the visual analog scale of 10 cm."	Signs or symptoms of: meniscal or intra-articular pathology; previous knee joint ligament injuries; ligamentous laxity; sign of patellar apprehension; Osgood-Schlatter or Sinding-Larsen-Johansson syndrome; lumbar spine,  hip or ankle pain; prior patellar dislocation; evidence of knee joint effusion; lower limb surgery; cardiovascular or neurological  diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-39z9pb	study to the evaluate non-inferiority Compared two local anesthetic for orthopedic procedures on the lower limbs	Not yet recruiting	Intervention	2015-02-25	<NULL>	<NULL>	405	Phase III study to evaluate the noninferiority of levobupivacaine with excess 50% (levobupivacaine S75: R25) heavy compared to racemic bupivacaine (bupivacaine S50: R50) heavy in spinal anesthesia for lower limb orthopedic procedures	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-07-01	Faculdade de Medicina do ABC	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-39z9pb	<NULL>	Patients who agree to participate in the study and signed the consent form, both sexes, aged between 18 and 80 years inclusive, ASA I or ASA II with indication for spinal anesthesia for orthopedic surgery of the lower limbs	Absolute or relative contraindications to spinal anesthesia ; intolerance or hypersensitivity to local anesthetics or components of the formula , spinal cord injuries , peripheral neuropathy or other neurological disorders that lead to disturbances of sensation and / or motor function , dementia , mental retardation and other important cognitive changes ; obesity with body mass index ? 35 or difficulty in executing the puncture ; anatomical difficulty column in the Investigator&apos;s opinion , previous surgery of the spine ; polytrauma ; tattoo at the puncture site , alcoholism , substance abuse , history severe Stevens- Johnson anaphylactic reactions, changes in safety tests ( INR &gt; 1.4 , platelet count &lt; 100,000 mm3 , blood glucose &gt; 200mg/dl , bradyarrhythmias , heart block , frequent premature ventricular beats or saved evident on ECG ) ; participation in any clinical trial within the 12 months preceding their inclusion , pregnancy or lactation, any other condition that , in the Investigator&apos;s opinion , may lead to increased risk to the patient.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-6hmfk8	Study to evaluate the safety and efficacy of TAVR device.	Not yet recruiting	Intervention	2015-02-17	<NULL>	<NULL>	414	The TAVR feasibility Study_a pilot non-randomised single-arm clinical study to evaluate the feasibility and safety of the valve medical TAVR product in patients with severe symptomatic aortic stenosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Instituto Dante Pazzanese	Instituto Dante Pazzanese	https://ensaiosclinicos.gov.br/rg/RBR-6hmfk8	<NULL>	"Age &gt; or = 18 years; Understand the implications of participating in the study and provide informed consent; Be suitable candidate for surgical aortic valve replacement; Comply with specified follow-up evaluation and be contacted by telephone; Present severe aortic stenosis: AVA &lt; or =  0.8 cm2 (or AVA index &lt; or = 0.5cm2/m2) AND PV &gt; 4 m/sec or mean
gradient &gt; 40 mmHg; Present cardiac symptoms: &gt; or =  NYHA Class II; Have co-morbidities associated with an increased surgical risk profile: (1) EuroSCORE &gt; or = 20% or STS &gt; or = 8% or (2) other high surgical risk factors as determined by the Heart Team (e.g. porcelain aorta, extreme frailty, liver disease, etc.); Have aortic annulus diameter &gt; or = 22 mm and &lt; 26 mm, assessed by both trans-thoracic echocardiography and by CTA; Have peripheral vessels (common femoral and iliac arteries) of acceptable size, tortuosity, and calcification to accommodate the 12Fr catheter system"	"Congenital unicuspid or bicuspid valve, or noncalcified aortic valve; Mixed aortic valve disease (aortic stenosis and aortic regurgitation with predominant aortic regurgitation &gt; or = 3+); Active or recent (within 6 months) endocarditis;  Other active infections; Recent MI (&lt; or = 1 month); Any therapeutic invasive cardiac procedure (except BAV) performed within 30 days of the index procedure; Prosthetic heart valve in any position;  Severe (&gt; 3+) mitral regurgitation; Blood dyscrasias as defined: leukopenia (WBC&lt;3000/mm3), acute anemia (Hb &lt;8mg%),
thrombocytopenia (platelet count &lt;50,000 cells/mm&apos;), history of bleeding diathesis or coagulopathy; Untreated clinically significant coronary artery disease requiring revascularization; Hemodynamic instability requiring inotropic support or mechanical support devices; Hypertrophic cardiomyopathy with or without obstruction (HCM); Severe ventricular dysfunction with left ventricular ejection fraction (LVEF) &lt;20%; Echocardiographic evidence of intracardiac mass, thrombus or vegetation; Active peptic ulcer or upper GI bleeding within the prior 3 months; Known hypersensitivity or contraindication to aspirin, heparin, or clopidogrel, or sensitivity to contrast media (which cannot be adequately premedicated); Recent (&lt;6 months) cerebrovascular accident (CVA) or transient ischemic attack (TIA); Renal insufficiency (creatinine &gt; 3.0) and/or end stage renal disease requiring chronic dialysis; Severe aortic disease, including abdominal aortic or thoracic aneurysm (lumen diameter &gt; 5cm), marked tortuosity, or severe aortic arch atheroma; Aortic annulus diameter &lt;22 mm and &gt; or = 26 mm, assessed by trans-thoracic echocardiography and CTA; Peripheral vessels (common femoral and iliac arteries) NOT of acceptable size, tortuosity, and calcification to accommodate the 12Fr catheter system (&gt; or = 4mm diameter); Life expectancy &lt; 12 months due to non-cardiac co-morbid conditions; Currently participating in an investigational drug or another device study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-2ht76k	Comparison of methods for masticatory function evaluation	Not yet recruiting	Intervention	2015-03-18	<NULL>	<NULL>	424	Comparison of methodologies applied to masticatory function evaluation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Odontologia de Piracicaba UNICAMP	Faculdade de Odontologia de Piracicaba UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-2ht76k	<NULL>	Health subjects; both gender; aged from 25 to 70 years; complete natural dentition or total edentulism wearing a conventional complete denture or a implant supported mandibular dentures.	Diagnostic of caries; periodontal disease; facial malformations; severe malocclusion; posterior crossbite; anterior open bite; parafunctional habits; temporomandibular disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-338wd8	Nonablative radiofrequency and phototherapy in facial wrinkles	Not yet recruiting	Intervention	2015-03-23	<NULL>	<NULL>	427	Effects of nonablative radiofrequency and phototherapy in reduction of periorbital and nasolabial wrinkles in young adult women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-23	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-338wd8	<NULL>	Healthy volunteers; female; aged between 30 and 50 years old; white to light brown skin phototype according to Fitzpatrick	Volunteers with skin sensitivity; who have performed facial cosmetic procedures or surgeries recently (for example: rhytidectomy and / or blepharoplasty, and chemical or physical ablative peeling in the last 12 months and who have made the past 6 months botulinum toxin or fills with collagen implants)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-3pyzt5	Efficacy and tolerability of Meclin® (meclizine hydrochloride) in Acute vertigo (a type of dizziness) and other types of dizzy spells identified by Otorhinolaryngologist	Not yet recruiting	Intervention	2015-03-10	<NULL>	<NULL>	428	Eficacy and tolerability of Meclin®(Meclizine Chlorhydrate) in acute vertigo	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-23	Universidade Federal de São Paulo - UNIFESP/EPM	Apsen Farmacêutica S/A	https://ensaiosclinicos.gov.br/rg/RBR-3pyzt5	<NULL>	Men and Woman aged above 18 years with presence of dizziness / vertigo of vestibular origin symptons , due to peripheral vestibular disorders, with dizziness / vertigo of vestibular origin symptoms, show  moderate intensity on in  5-points Likert  scale of: absent, mild , moderate , severe and very severe, if woman, negative Beta hcg and who present normal or controlled blood pressure;	Used meclizine or dimenidrynate in 15 days; Used alcohol in 48 hours; Pregnancy or breastfeeding; Presence of vomiting which prevent the ingestion of tablets; Presence of clinical condition that determines contraindication to the active substances : convulsions , suspected intracranial compressive processes , closed-angle glaucoma , prostatic adenoma with urinary disorders , liver diseases , endocrine , renal, and / or uncontrolled cardiovascular , Parkinson&apos;s disease; Participants with bladder neck obstruction or symptomatic prostatic hyperplasia : anticholinergic effects of Meclizine may precipitate urinary retention; a known sensitivity to hydrochloride, meclizine or dimenhydrinate; Presence of malignant carcinomas or not remitted for more than 5 years;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-6w25zv	The Effectiveness of Acupuncture for patients with Tinnitus	Not yet recruiting	Intervention	2015-04-06	<NULL>	<NULL>	436	The Effectiveness of Acupuncture for patients with Tinnitus in relation to vitamin D and the amount of protein of IL6 and TNF Alpha activity: randomized crossover trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-11	Universidade Norte do Paraná - UNOPAR	Universidade Norte do Paraná - UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-6w25zv	<NULL>	Elderly individuals complaining of tinnitus of sensorineural origin; Men and women; Age 60 years or more.	Subjects presenting active cardiovascular disease;Cardiac pacemaker; Metallic prostheses or implants; Complaint of origin buzz for auditory; Working in a noisy environment or have a history of noise-induced hearing loss; Submit THI Questionnaire total score in less than thirty-six (36); Submit scores on the visual analog scale (VAS) less than five (5).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-2cnzk7	Assessment the Effect of Combined Treatment of diuretic 1.5mg/angiotensin receptor antagonists 50mg and diuretic 1.5mg/angiotensin receptor antagonists 100mg, Compared With 1.5 mg diuretic Monotherapy in the Treatment of Hypertension	Not yet recruiting	Intervention	2015-04-07	<NULL>	<NULL>	441	"Randomized, phase III, multicenter, double-blind, double-dummy trial to assess the effect of combined treatment of Indapamide 1.5mg / Losartan 50 mg and 
Indapamide 1.5mg / Losartan 100mg, compared to monotherapy Indapamide 
1.5 mg in the treatment of essential hypertension"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-12-20	Hospital do Coração/Associação do Sanatorio Sírio	Dr. Celso Amodeo	https://ensaiosclinicos.gov.br/rg/RBR-2cnzk7	<NULL>	"Patients of both sexes, aged &lt;18 years; Patients with systemic hypertension (defined by medical researcher) alone (not by thiazide diuretic) and have at least two blood pressure measurements &lt;140/90, in sitting position, with 5 minutes interval; Patients with laboratory test results, in a period of up to 6 months before, within normal values ??(chemistry, hematology and urinalysis) or that the researcher considers them not clinically significant;
Patient who is willing to continue treatment for hypertension with medications the study. In this case, the patient will be randomized to drug or the combined use of thiazide diuretic, which would be internationally recommended drug for treating essential hypertension. If the patient is using other drug class, to include it in the study and perform the exchange of medication thiazide diuretic, it will be getting the best treatment available and recommended by national and international guidelines for its pathology."	Patients with blood pressure , 180/100 mmHg;Presence of concomitant coronary artery disease, congestive heart failure, diabetes and renal failure (creatinine&gt; 1.5 mg / dL);Patients with hypo or hyperkalemia (serum potassium outside normal range); Patients with alanine aminotransferase greater than 2.5 the upper limit of normal or active liver disease; Pregnant women, or women in childbearing age who are not in use effective contraception or intending to become pregnant during the study period; Patients on drug or alcohol abuse in the last two years; Patients with secondary hypertension (renovascular disease, pheochromocytoma, Cushing&apos;s syndrome); Patients with allergic reactions or hypersensitivity to ACE inhibitors, diuretics or medications containing sulfa and / or any excipients of formulation; Refusal or inability to provide the Informed Consent Term.; Refusal to discontinue the anti-hypertensive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-6hp2gq	Use of games in the treatment of postural deviations of schoolchildren aged 10 to 15 years	Not yet recruiting	Intervention	2015-04-10	<NULL>	<NULL>	442	Game therapy in the treatment of postural deviations of schoolchildren aged 10 to 15 years	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-05	Universidade Estadual do Centro-Oestre	Universidade Estadual do Centro-Oestre	https://ensaiosclinicos.gov.br/rg/RBR-6hp2gq	<NULL>	Children and adolescents with postural desviations; aged 10 and 15. The sample size will be 24 participants.	People with physical or mental disabilities; orthopedic injury , trauma or rheumatic ; having undergone surgery on the spine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-4f6sh5	A study for evaluation of efficacy and safety of medicine for adult obesity treatment	Not yet recruiting	Intervention	2015-04-14	<NULL>	<NULL>	445	Prospective study, parallel, double-blind, multicenter, for evaluation of efficacy and safety of Orlistat 60mg for adult obesity treatment compared to Orlistat 120mg	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-01-15	Marcio Antonio Pereira Clinica Médica de Endocrinologia LTDA	Marcio Antonio Pereira Clinica Médica de Endocrinologia LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4f6sh5	<NULL>	Signed Informed Consent; Adults Male and Female over 18 years old; Obesity (body mass index equal or greater 25kg/m2);	Pregnancy and Lactation or women without effective contraception;Patients with Relevant chronic degenerative diseases;Obesity associated to genetic syndrome or other diseases;Patients with a history of hospitalization for decompensated diabetes in the last 6 months;Psychiatric disorders;Alcoholism: consumption of more than 3 doses of distillate, or any alcoholic drink daily; History of alimentary disorders, for example: bulimia; Use of anorectics, herbal and / or any drug (s) with or without approved indication for weight loss in the last 30 days; Use of drugs or laxatives for constipation in the last 30 days; Any history of Inflammatory Bowel Disease; History of acute diarrhea (viral or bacterial) in the last 30 days or chronic diarrhea; Patients using cyclosporine, amiodarone, dicumarinic; Prior bariatric surgery; History of anemia; Hemoglobinopathies and coagulopathy; History of cancer in the past five years; Use of corticosteroids, oral or injectable, in the last 30 days; People Related to investigators, family, employees of the sponsor or linked to the study center; Have participated in another study in the last two months; Patients who have no ability to observe / record the occurrence of gastrointestinal events.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-62qfc8	Octreoscan - kits production of tumor diagnosis neuroendocrine	Not yet recruiting	Intervention	2015-04-25	<NULL>	<NULL>	457	Octreoscan - kits production of tumor diagnosis neuroendocrine	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UBEA - União Brasileira de Assistência e Saúde	Grupo Radiopharmacus - RPH	https://ensaiosclinicos.gov.br/rg/RBR-62qfc8	<NULL>	Patients with histologically proven TNE; Which have been referred for the exam with 111In for staging disease and / or response to treatment; Any stage of the disease; 18 years old; Both sexes; Without receiving medication with somatostatin analogues for at least one month prior to taking pictures.	"Pregnant women;
Patients with previous resection of primary tumor without metastatic disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5kd6sn	The clinical effect of physical therapy and osteopathy in chronic low back pain patients	Not yet recruiting	Intervention	2015-05-08	<NULL>	<NULL>	465	The clinical effectiveness of conventional therapy versus osteopathic manipulative treatment in patients with chronic nonspecific low back pain: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	Hospital Universitário Gaffrée e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-5kd6sn	<NULL>	Pacients in the physiotherapy sector at the Gaffrée and Guinle University Hospital (HUGG); which have low back pain for more than three months; which have not undergone physiotherapy treatment in the last three months.	Patients who have a history of abdominal and lumbar surgery; infection; vertebral fracture; ankylosing spondylitis; cauda equine syndrome; cancer; radiculopathy in lumbar levels; lumbar stenosis; rheumatic syndromes and patients who receive some benefit labor.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5jbxsf	Effects of protein supplementation in patients with low energy diet for the treatment of weight regain in the late postoperative surgical reduction of the stomach	Not yet recruiting	Intervention	2015-05-11	<NULL>	<NULL>	466	Efects of Metabolic and nutritional protein supplement diet in patients with low energy diet for treatment of weight regain in the late postoperative bariatric surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-07	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5jbxsf	<NULL>	60 patients 18-55 years old, female, undergoing surgery for gastric bypass with surgery in Roux-Y for more than 24 months and who had regained weight of at least 5% of the lowest weight achieved during treatment.	Patients with decompensated diabetes on hormone treatment, with renal or hepatic disease or using any medication for loss weight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-7z358j	Effects of different oils consumption associated with diet on weight loss	Not yet recruiting	Intervention	2015-05-13	<NULL>	<NULL>	471	Effect of different fat sources consumption associated with low-calorie diet in controlling excess body weight	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade Federal de Viçosa - UFV	Faculdade de Ciências Aplicadas da UNICAMP - Limeira	https://ensaiosclinicos.gov.br/rg/RBR-7z358j	<NULL>	women; with 20 to 40 years old; overweight and with high body fat; basal energy requirements between 1200 to 1500kcal/day	presence of chronic diseases; weight and physical activity instability; use medication that affects some parameter assessed in the survey; smokers; pregnant or lactating; presence of eating disorders; presence of intestinal disorders; alcoholic.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-34677v	Use of videogames as physical training for children and adolescents with cystic fibrosis during hospitalization	Not yet recruiting	Intervention	2015-06-09	<NULL>	<NULL>	508	Use of interactive games as aerobic training for children and adolescents with Cystic Fibrosis during hospitalization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-34677v	<NULL>	17 individuals diagnosed with cystic fibrosis; both sgenders; aged from six years; hospitalized at São Lucas Hospital (PUCRS).	Children and adolescents with arm/leg problems that could interfere in the exercise performance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4phm6k	Eficacy and safety study of drug that contains Pycnogenol which is used to treat spot on the skin	Not yet recruiting	Intervention	2015-06-09	<NULL>	<NULL>	509	Randomized, double-blind clinical study in order to assess the tolerability and dermatological efficacy of a drug that contains Pycnogenol, which is used to treat Melasma	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-10-01	Medcin Instituto da Pele	Farmoquimica	https://ensaiosclinicos.gov.br/rg/RBR-4phm6k	<NULL>	"100 participants; age range 25-65 years old; female; fitzpatrick skin types II and III;
patients with facial melasma; without any other cutaneous disease; without previous reaction to topical product; the patient should agree with the study-related procedures and the determinated days and time of  appointments; Reading; understanding; agreement and signature of patient on the written informed free consent form."	Pregnancy; lactation; hormonal therapy within the last 4 weeks; use of photosensitizing  drug; any melasma treatment in the same time;intensive solar exposure within the last 15 days and during the study; cutaneous marks on the experimental area that might  interfere with cutaneous reaction evaluation; use of corticoide until 30 days before the selection and during the study;endocrine dysfunction; use of cosmetic products that might cause any facial irritation , even if it is mild such as exfoliating and antiaging products; other conditions that may  be considered by doctors as a reason for disqualification of patient’s participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6qbztf	Biomaterials for preventing sensibility after home bleaching	Not yet recruiting	Intervention	2015-07-09	<NULL>	<NULL>	540	"Randomized clinical trial of the nano-hydroxyapatite and arginine effect for the 
dentin sensibility prevention after bleaching home treatment"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de odontologia da Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6qbztf	<NULL>	"60 people aged between 18 and 26 years;
any genders; good health; non-moking;
pH and salivary flow within normal limits;
healthy teeth and initial color A2 or darker
according to the Vita scale."	"Having received previous dental bleaching;
restorations on the anterior teeth; pregnant
or nursing women; having teeth darkened by
tetracycline, fluorosis or endodontic 
treatment; patients with teeth grinding;
having noncarious
cervical lesion; and
dentin hypersensitivity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-69t579	Study of heart and breath during the prosthesis hip setting about raquianesthesia	Not yet recruiting	Observational	2015-07-14	<NULL>	<NULL>	545	Study of haemodynamic repercussion across the cardioimpedance during the use of methylmethacrylate in total Hip Arthroplasty about Raquianesthesia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-69t579	<NULL>	Volunteers with Hip ostheoarthrosis diagnosis; above 65 years old;both gender	Anemia; diagnosis of asthma or pulmonary disease, cardiac	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-7jyccp	"Biomaterials for preventing sensibility after
home bleaching"	Not yet recruiting	Intervention	2015-07-19	<NULL>	<NULL>	551	Randomized clinical trial study of effect of potassium nitrate and strontium chloride  associated to the bleaching home treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de odontologia da Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7jyccp	<NULL>	"60 people aged between 18 and 26 years;
any genders? good health; no-snmoking;
pH and salivary flow within normal limits;
healthy teeth and initial color A2 or darker
according to the Vita scale."	"Having received previous dental bleaching;
restorations on the anterior teeth; pregnant
or nursing women; having teeth darkened by
tetracycline, fluorosis or endodontic
treatment; patients with teeth grinding;
having noncarious
cervical lesion; and
dentin hypersensitivity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-55kzbn	Biomechanical analysis in individuals with anterior knee pain and its treatment	Not yet recruiting	Intervention	2015-07-27	<NULL>	<NULL>	558	Morphological, neurofunctional, kinetics and kinematics analysis in individuals with patellofemoral pain syndrome and its treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-55kzbn	<NULL>	It will be included 40 participants with unilateral or bilateral patellofemoral pain; aged between 18 and 35 years; report onset of symptoms insidiously not related to a traumatic event; should have pain (at least 3 of 10 points according visual analogue scale) in retropatellar or peripatellar region at least three of the following functional activities: up or down stairs; run; kneeling; squat; stand for long periods sitting; jumping; isometric contraction of the quadriceps and palpation of the lateral and / or medial side of the patella; and the presence of pain for at least two months. Also; it will be included 40 participants without pain; aged between 18 and 35 years and they should present any history of injury or pain in the knees.	Both groups should not have history of surgery on knees; history of injury or pain in the hip; patellar instability; pain on palpation of the patellar tendon; iliotibial band or tendons of goose foot; signs or symptoms of meniscal or ligament injuries of the knee; presence of Osgood-Schlatter disease or Sinding-Larsen-Johansson syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-95xwc7	Evaluation of effects of differents montages of non invasive brain eletrical stimulation in funcionality of children with cerebral palsy of type spastic hemiparesis	Not yet recruiting	Intervention	2015-07-27	<NULL>	<NULL>	559	Effects of differents montages of tDCS in functionality of children with Cerebral Palsy of type Spastic Hemiparesis: clinical trial randomized, placebo-controlled and double blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-10	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-95xwc7	<NULL>	Inclusion criteria will be thirty children who: a) have the diagnosis of CP spastic hemiparesis; functionally classified as levels I and II by GMFCS (Palisano et al, 1997;. Hiratuka et al, 2010).; have independent walking at least 12 months; the age group of six and ten years of life; have degrees of understanding and consistent collaboration with the completion of the proposed activities; The parents agree with their participation in the study by signing the Informed Consent	Children who will be excluded have undergone surgical procedures or neurolytic blocks in the last 12 months before the start of the training sessions; presenting structured orthopedic deformities with surgical indications; have epilepsy; having metal implant in the brain or hearing aids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-7s6ymc	Effect of low-level laser and exercise improving balance and functionality in people with knee osteoarthritis	Not yet recruiting	Intervention	2015-07-28	<NULL>	<NULL>	563	Effect of Low-level Laser Therapy associated or not to exercise in subjects with knee osteoarthritis: randomized study on the impact of physical therapy clinical trial on postural control and functionality	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7s6ymc	<NULL>	Individuals of both genders, with ages between 40 and 70 years, with or without knee osteoarthritis.	Cardiovascular disease; neurological or musculoskeletal that disables the volunteer to perform exercises; evidence of secondary disease, inflammatory or metabolic; osteonecrosis and previous intra-articular injection; surgery in the previous three months to inclusion in the study or use of drug treatment that could potentially have an effect on the results of study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-7m2756	Effect of an exercise program on cardiopulmonary function and quality of life in patients after gastric bypass surgery	Not yet recruiting	Intervention	2015-07-30	<NULL>	<NULL>	568	Impact of an exercise program on cardiopulmonary function, functional capacity and quality of life in patients undergoing Bariatric Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7m2756	<NULL>	Obese patients who are part of the Surgery of Obesity and Related Disorders (SCODE) of HUOL and UFRN; target sample of 24 subjects; having a BMI above 30 kg / m2; both genders; aged between 18 and 50 years; presented FVC and FEV1 values above 80% of the predicted age obtained in spirometry; signed an informed consent form.	Cognitive and / or neurological disorders; orthopedic impairments; diagnosis of chronic obstructive pulmonary disease (COPD) and / or severe cardiovascular disorders such as unstable angina, valvular heart disease, acute arrhythmias, acute myocardial infarction in the last month, high blood pressure and / or uncontrolled diabetes mellitus; presence of cardiac pacemakers; patients who present contraindications to perform the Cardiopulmonary Exercise Test III Guidelines established by the Brazilian Society of Cardiology About Exercise Stress Test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-2kpz5j	Analysis of microorganisms existing in denture wearers before and after the use of two adhesives	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	587	Oral microbiota analysis of conventional complete dentures wearers before and after the use of two adhesives	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Estadual Paulista - UNESP	CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-2kpz5j	<NULL>	Adult individuals; receptive and mentally agile; good understanding of spoken Portuguese; with availability to attend evaluations during the experimental phase; alveolar ridges with normal resilience and volume	Systemic debilitations; use of antibiotics at the moment of inclusion in the study and for 3 months prior to the first assessment or sample collection; previous use of denture adhesives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-9msy3t	Effects of the elastic bandage on the symptoms of medial tibial stress syndrome in runners	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	588	Effects of the elastic bandage on the symptoms of medial tibial stress syndrome in runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9msy3t	<NULL>	Sixty athletes that run during their training; the run training occurs at least three times a week; presence of the medial tibial stress syndrome induced by sports practice for at least six weeks and pain on palpation in the distal posteromedial border of the tibia.	Suspicion of tibial stress fracture or compartment syndrome; history of surgery in lower limbs or tibia fracture; paresthesia; other conditions that cause pain in the leg or presence concurrent pain; such as pain in the knee or ankle sprains.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-3j6rdg	Intravenous infusion of a single solution with with midazolam and fentanyl versus intravenous infusion of midazolam and fentanyl in separate solutions	Not yet recruiting	Intervention	2015-08-17	<NULL>	<NULL>	591	Intravenous infusion of  a combined solution of midazolam and fentanyl solution vs separated midazolam and fentanyl	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-01-01	Hospital do Servidor Público Municipal	Hospital do Servidor Público Municipal	https://ensaiosclinicos.gov.br/rg/RBR-3j6rdg	<NULL>	A total of 40 consecutive patients will be included; aged between 1 month and 16 years and requiring mechanical ventilation; with an expected mechanical ventilation duration of at least 48 h and requiring sedative/analgesic drugs infusion.	Patients under 1 month old; patients over 16 years old; presenting severe neurological injury or central nervous system impairment that could affect the assessment of the sedation level. Also; patients will be excluded if they receive any neuromuscular blocking agent or another sedative drug (e.g.; ketamine; dexmedetomedine; clonidine; thiopental; thionembutal; chloral hydrate) during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-6cf4xh	A preliminary study for testing a new drug to kidney stones treatment	Not yet recruiting	Intervention	2015-08-18	<NULL>	<NULL>	592	A Phase I/II clinical trial for evaluating safety and efficacy of an innovative medicine to nephrolithiasis treatment	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2016-01-04	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Apis Flora industrial e comercial limitada	https://ensaiosclinicos.gov.br/rg/RBR-6cf4xh	<NULL>	18 to 55 years old; male; any race, healthy volunteers; non-smoking; without drug addiction, use of alcohol or medicines.	Female; elderly (age&gt;55years); any clinically detectable disease, found on clinical history or physical examination; abnormal ECG (except unspecific ventricular repolarization changes, sinus brady/tachycardia); abnormal laboratory tests in blood cells count, kidney, reproductive, metabolic or hepatic function; participation in clinical trials in the last year; history of allergic reaction to medicines; use of any drug one week before the beginning or during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-85bbp4	Clinical study to compare recombinant human growth hormone Cristália (r-hGH Cristália) versus Genotropin® pre puberty in children with failure to thrive due to deficiency of growth hormone.	Not yet recruiting	Intervention	2015-09-09	<NULL>	<NULL>	608	Clinical study to compare recombinant human growth hormone Cristália (r-hGH Cristália) versus Genotropin® in prepubertal children with growth deficiency due to deficiency of growth hormone.	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2015-10-01	ICF - Instituto de Ciências Farmaceuticas de Estudos e Pesquisas LTDA	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-85bbp4	<NULL>	Children aged 4 years and 13 years (for girls) and 14 years (for boys); Children prepubertal (Tanner stage 1); Bone age less than 11 years (for boys) and 9 years (for girls), documented by radiographs of the hand and wrist (will accept a radiograph performed within 6 months prior to enrollment in the study); Naïve children with growth hormone; Children diagnosed with disturbance in growth due to deficiency of growth hormone documented before initial treatment with r-hGH through: The height z score &lt;-2.0 SD for age and sex; A response to a test stimulus GH release with peak blood 7 ng / ml in the presence of abnormalities morphostructural hypothalamic-pituitary region shown by Nuclear Magnetic Resonance (NMR) or; response to stimulus two tests of GH release with peak  7 ng / ml in the presence of a normal NMR (stimulating agents are acceptable insulin, clonidine, glucagon, arginine and L-dopa). Historical values of GH in blood up to 12 months prior to enrollment in the study will be acceptable. An MRI performed up to 2 years before inclusion in the study is acceptable; History of growth velocity below the mean for the normal population for at least 6 months prior to inclusion in the study, according to the table of VC Tanner (must be historical height data with a minimum of 6 months and maximum of 18 months. Researcher must ensure that the measurements were performed in a standardized way in standard stadiometer (rigid deck and rigid ruler); Baseline IGF-I -0.5 SD for age and sex (results provided by the central laboratory).	"Children aged &lt;4 years; Children with clinical signs of puberty (breast / genitalia and pubic hair Tanner stage 2); Note: Children who enter puberty during treatment (breast development Tanner 2 / or testicles 4 ml or 2.5 cm in greatest diameter) shall be excluded; Other causes of disorder in children including growth in stature for gestational age (SGA), Turner syndrome, Prader-Willi syndrome, other causes; Children with closed epiphyses bone; Children with physical changes that prevent accurate measurement of height; Children with comorbidities that prevent normal growth. Patients with central hypothyroidism may be included, if well controlled with l-thyroxine, evidenced by normal free T4 dosages; dysmorphic syndrome; Presence of signs of skeletal dysplasia; Evidence of active malignancy or with less than two years of treatment considered curative; uncontrolled growth of benign intracranial tumors; Children with benign intracranial hypertension; Children with clinical evidence of malnutrition considered relevant to the discretion of the investigator; Children with Diabetes mellitus type 1 or 2; severe acute disease, including complications after heart surgery by thoracotomy, abdominal surgery, multiple accidental trauma or acute respiratory failure; concomitant chronic disease which may interfere with the analysis of the study (eg, hyperthyroidism / uncontrolled hypothyroidism, gastrointestinal diseases, cardio-respiratory diseases, liver failure, kidney failure, bone pathologies that can affect the growth, chronic inflammatory diseases and inborn errors of metabolism); Patients with hormone deficiency related diseases by panhypopituitarism may be included if properly controlled; MRI findings that may interfere with the study drug (examples: intracranial hypertension, tumors in the hypothalamic-pituitary region); Children with anti-GH antibodies;
Children undergoing treatment for the disorder or attention deficit hyperactivity disorder deficit hyperactivity disorder; Concomitant medication that could influence the secretion of growth (eg, estrogen, androgen, anabolic steroids, steroids, aromatase inhibitors) hormone. Physiological doses of corticosteroids for the treatment of pituitary deficiency are allowed as well as low-dose inhaled and / or nasal steroids for the treatment of asthma or chronic rhinitis (500mcg or less / day beclomethasone or equivalent); or known allergy to the study medications, or any of the excipients or thinner / solvent hypersensitivity; Participation in another clinical study within 3 months before study entry; Statement of legal limitation disability or parent / legal representative"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-9py4kd	Use of misoprostol before hyteroscopy exam to evaluate intrauterine in postmenopausal women.	Not yet recruiting	Intervention	2015-09-17	<NULL>	<NULL>	616	Use of misoprostol prior to hysteroscopy in postmenopausal women: a randomised, placebo-controlled clinical trial.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-9py4kd	<NULL>	182 Menopausal women with minimum age of 50 and maximum of 80 referred for endometrial assessment by hysteroscopy.	"Women with lower genital tract infection.
Women who have had intrauterine diseases that were previously treated by endoscopy.
Women who have never had sexual relations; with uterine malformation; with mental disabilities or undergoing pelvic radiotherapy.Women who refused to participate in the study.Women who had metrorrhagia during the exam."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-843tnq	Treatment of HIV/AIDS patients with Glutamine Dipeptide	Not yet recruiting	Intervention	2015-09-21	<NULL>	<NULL>	622	Impact of Glutamine Dipeptide Supplementation in HIV/AIDS patients treated with antiretroviral therapy.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	UEM-Universidade Estadual de Maringá	UEM-Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-843tnq	<NULL>	HIV positive; both genders; between 18 and 60 years; regular use of antiretroviral therapy; good adherence to therapy; HIV viral load stable in the last 6 months	pregnant women; psychiatric patients; more than 60 years old; chronic kidney disease;  swallowing difficulty.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-8d26mf	Effect of the Mediterranean diet on state inflammatory, lung function and quality of life of patients with cystic fibrosis: randomized controlled trial	Not yet recruiting	Intervention	2015-09-30	<NULL>	<NULL>	623	Effect of the Mediterranean diet on state inflammatory, lung function and quality of life of patients with cystic fibrosis: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal do Rio Grande do Sul	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8d26mf	<NULL>	Patients diagnosed with cystic fibrosis (n=40) confirmed by two tests dosage Na and Cl in the identification or sweat 2 mutations known to be related to illness and aged 6-18 years.	"Patients with advanced lung disease (FEV1 &lt; 40%); Patients using oral corticosteroids in the last two months and inability to
perform pulmonary function tests."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-9y73dr	evaluation of 2% chlorexidine in root canal treatment in primary teeth	Not yet recruiting	Intervention	2015-12-02	<NULL>	<NULL>	654	Evaluation of chlorhexidine 2% in pulp therapy for primary teeth with pulp necrosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-19	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Centro Universitário Franciscano	https://ensaiosclinicos.gov.br/rg/RBR-9y73dr	<NULL>	Children 5 to 10 years who have at least one primary molar with pulp necrosis and indication pulpectomy.	indication for extraction during the endodontic procedure; impossibility of collecting the microbiological root canal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-5sj53s	Multicenter Study of the Accuracy and Feasibility of the Xpert Ultra Test	Not yet recruiting	Observational	2015-12-16	<NULL>	<NULL>	657	Multicenter Study of the Accuracy and Feasibility of the Xpert Ultra Test	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	National Institute of Allergy and Infectious Diseases (NIAID)	Núcleo de Doenças Infecciosas	https://ensaiosclinicos.gov.br/rg/RBR-5sj53s	<NULL>	"Inclusion Criteria for Case Detection Group
• Age 18 years or above;
• Provision of informed consent;
• Willingness to provide up to 4 sputum specimens at enrollment;
• Willingness to have a study follow-up visit 42 to 70 days after enrollment;
• Clinical suspicion of pulmonary TB (including cough ?2 weeks and at least 1 other symptom typical of TB.

Inclusion Criteria for Drug Resistant TB Group
• Age 18 years or above;
• Provision of informed consent;
• Willingness to provide 3 sputum specimens at enrollment;
• Clinical suspicion of pulmonary TB (including cough ?2 weeks and at least 1 other symptom typical of TB);
• Meets at least one of the following criteria: 
A) microbiologically-confirmed pulmonary TB with documented rifampin resistance who has received anti-tuberculosis therapy for 31 days or less; 
B) known pulmonary TB with suspected treatment failure;
C) history of drug-resistant TB AND off anti-TB therapy for ? 3 months"	"Exclusion Criteria for Case Detection Group
• Receipt of more than two doses (two days) of TB treatment within 6 months prior to enrollment;
• Participants for whom, at the time of enrollment, the follow-up visit is judged to be poorly feasible (e.g. individuals planning to relocate).

Exclusion Criteria for Drug Resistant TB Group
• No exclusion criteria"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-9gh46r	Effects of different modalities and different intensities of physical rehabilitation on the Elimination of protein in the urine in patients with chronic kidney disease not requiring dialysis hypertensive origin	Not yet recruiting	Intervention	2016-01-12	<NULL>	<NULL>	680	Action of different modalities and intensities of physical rehabilitation on albuminuria of patients with non-dialysis dependent hypertensive nephrosclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Faculdade de Medicina de Botucatu	Prefeitura Municipal de Itaí	https://ensaiosclinicos.gov.br/rg/RBR-9gh46r	<NULL>	Minimum age of 18 years; patients with chronic kidney disease in hypertensive origin; with elimination of the protein albumin in the urine with more than 30 milligrams per gram of creatinine, family history of hypertension, hypertension preceding the elimination of prteína; the presence of ventricular hypertrophy on electrocardiogram signals.	Patients who are on dialysis; Albuminuria greater than or equal to 2,000 milligrams per gram of creatinine; History or evidence of angina or myocardial infarction; Treadmill exercise test positive for coronary heart disease; Cardiac arrhythmias; Musculoskeletal restrictions that preclude participation; Hemodynamic instability; Diabetic patients; Exposure to nephrotoxins; Evidence glomerular diseases; Presence of systemic diseases that can affect the kidneys.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-2qfjpv	The effectiveness of HIV preventive methods in Brazilian health service	Not yet recruiting	Intervention	2016-01-13	<NULL>	<NULL>	681	Pre- and post-exposure prophylaxes and the combination HIV prevention methods: protocol for a pragmatic clinical trial at public healthcare clinics in Brazil	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2015-09-01	Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo	SAE Vila dos Comerciários - SMS de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2qfjpv	<NULL>	"Seek care in service for the use of PEPsexual or report sexual exposure to HIV in a consensual relationship in the last 30 days in accordance to the criteria defined by the Health Ministry for use of prophylaxis;
16 years of age or over; 
Negative anti-HIV test at the time when the clinic is sought, or positive anti-HIV serological test with negative/indeterminate western blot;
Having started PEPsexual at the clinic or having been referred for clinical follow-up soon after the initial attendance at an emergency service, provided that information on serological status, sexual exposure and prescribed therapy is available;
Having signed the free and informed consent statement."	Having sought PEPsexual for the purpose of assisted reproduction or due to occupational exposure or sexual violence;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-8w369s	The effect of medications to combat the generated sensitivity after the tooth whitening office	Not yet recruiting	Intervention	2016-01-19	<NULL>	<NULL>	688	Effectiveness of two drugs in controlling sensitivity generated by office tooth whitening: A clinical, randomized, blinded trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-09	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8w369s	<NULL>	Individuals must be at least 18 years old, doesn&apos;t have hipersenssibilidade to ibuprofen and codeine; be nonsmoking; have teeth with greater color A2; possess good oral and general health; have front teeth upper and lower vital; free of cavities or restorations without cervical lesions and without periodontal disease.	Pregnant women will be excluded or breastfeeding; people with discolored teeth caused by tetracycline; with fluorosis; hyperplasia; endodontic treatment or needing root canal treatment; and parafunctional habits. People who have any condition that may cause sensitivity such as recession or exposure of dentin are excluded from this study to minimize confusion of experimental variables or side effects of bleaching. Participants who report a health problem history in the stomach; heart; kidney; or liver or participants using any continuous drug with anti inflammatory action are also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-2qpsxw	Comparative analysis of the single photon diagnostic  tecnology (Spect/CT), with radiopharmaceutical application of Ecdg-99mTc , and computed tomography (CT)- in patients with Lung Cancer.	Not yet recruiting	Intervention	2016-01-28	<NULL>	<NULL>	696	A phase III study comparing the accuracy of Ecdg 99mTc SPECT/CT against CT for the diagnosis and staging of subjects with clinical and radiological  evidence  consistent with a diagnosis of lung cancer	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2015-10-15	Esho Empresa de serviços hospitalares S.A. – Hospital Pasteur	CCTECH Tecnologia em Imagem Molecular Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2qpsxw	<NULL>	Male or female subject with at least 18 years of age.  Women may not be pregnant or breast-feeding, and, for those in post-menopausal, the minimum period shall be 12 months for natural process, or 6 months in surgical cases. Agree to adhere to one of the birth control methods (contraceptives) as proposed protocol. Have evidence of lung cancer or CT study results consistent with a diagnosis of lung cancer. Not be receiving cancer treatment (surgery, radiotherapy and / or chemotherapy) or if the person has had lung cancer in the past, all previous therapy should have completed at least 3 months prior to the inclusion in the study. Must have a score in the instrument Eastern Cooperative Oncology Group (ECOG) less than or equal to 2. Present satisfactory laboratory values (l alanine aminotransferase less than or equal to 2.5 x ULN,  aspartate aminotransferase less than or equal  to 2.5 x ULN; less than or equal  to 2.5 x ULN; bilirubin less than or equal to 2.0 x ULN)	If there are any clinically relevant safety concerns (laboratory, ECG, physical examination, other) which, in the opinion of the investigator, put the subject in unnecessary risk if the subject were to participate. If, in the last 3 months, the patient has been submitted to any treatment for Cancer (radiation therapy, surgery or chemotherapy). Diabetic patient with insulin dependency. Weight limit higher than recommended by SPECT / CT and CT table. Known hypersensitivity to ECDG or contrast, or other compound, including any of the inactive ingredients. Pregnancy or suspected pregnancy, lactation, or planned pregnancy (male and female partners). Clinically significant mental illness that compromises the conduct of the study (which should be determined by the investigator).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-39247h	Validation for the portuguese fatigue assessment questionnaire in patients with cancer: Cancer Fatigue Scale (CFS)	Not yet recruiting	Observational	2016-03-01	<NULL>	<NULL>	728	Brazilian version of the Cancer Fatigue Scale (CFS): study of the validity and reproducibility	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal do Paraná	Liga Paranaense de Combate ao Câncer	https://ensaiosclinicos.gov.br/rg/RBR-39247h	<NULL>	Physical therapy patients 18-65 years of age; in outpatient treatment for primary breast cancer; individuals with communication skills and understanding preserved.	Pregnant women will be excluded; patients with psychiatric disorders and / or neurological; patients with decompensated heart disease; patients with chronic lung disease; individuals unable to answer the evaluation questionnaires (such as illiterate and speech/writing disorders).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-4hm9bf	A clinical trial investigating the anti-virus effects, kinetics and safety of GS-5806 in adults with RSV (respiratory syncytial virus) infection	Not yet recruiting	Intervention	2016-03-10	<NULL>	<NULL>	744	A phase 2b, randomized, double-blind, placebo controlled multi-center study evaluating antiviral effects, pharmacokinetics, safety, and tolerability of GS-5806 in hematopoietic cell transplant (HCT) recipients with respiratory syncytial virus (RSV) infection of the upper respiratory tract	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2015-07-01	Fundação Doutor Amaral Carvalho	Pharmaceutical Research Associates Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4hm9bf	<NULL>	Received an autologous or allogeneic hematopoietic cell transplantation (HCT) using any conditioning regimen; Documented to be RSV-positive (respiratory syncytial virus) as determined by local testing for example, PCR (polymerase chain reaction), DFA (direct fluorescent antibody), RVP (respiratory virus pannel) assay, or culture using an upper respiratory tract sample collected 6 days or less prior to Day 1; New onset of at least 1 of the following respiratory symptoms for 7 days or less prior to Day 1: nasal congestion, runny nose, cough, or sore throat, or worsening of one of these chronic respiratory symptoms 7 days or less prior to Day 1; No evidence of new abnormalities consistent with LRTI on a chest X-ray relative to the most recent chest X-ray, as determined by the local radiologist. If a chest X-ray is not available or was not obtained during standard care 48 hours or less prior to Screening, a chest X-ray must be obtained for Screening; O2 saturation equal or higher than 92% on room air; An informed consent document signed and dated by the subject or a legal guardian of the subject and the investigator or his or her designee; A negative urine or serum pregnancy test is required for female subjects, unless surgically sterile or greater than two years post-menopausal; Male and female subjects of childbearing potential must agree to contraceptive requirements as described in Appendix 5; Willingness to complete necessary study procedures and have available a working telephone or email.	Related to concomitant or previous medication use: Use of non-marketed according to region investigational agents within 30 days, OR use of any monoclonal anti-RSV antibodies within 4 months or 5 half-lives of Screening, whicheveris longer, OR use of any investigational RSV vaccines after HCT; Use of a strong cytochrome P450 enzyme inducer including but not limited to rifampin, St. John’s Wort, carbamazepine, and phenytoin, within 2 weeks prior to the first dose of IMP; Related to medical history: Admitted to the hospital primarily for a lower respiratory tract disease of any cause as determined by the investigator; Pregnant, reastfeeding, or lactating females; Unable to tolerate nasal sampling required for this study, as determined by the investigator; Known history of HIV and or AIDS with a CD4 count &lt;200 cells/microL within the last month; History of drug and/or alcohol abuse that, in the opinion of the investigator, may prevent adherence to study activities; Related to medical condition at Screening: A relapse, including molecular relapse, of the underlying disease for which they received a transplant at Screening; Documented to be positive for other respiratory viruses limited to influenza, parainfluenza, human rhinovirus, adenovirus, or human metapneumovirus within 7 days prior to the Screening visit, as determined by local testing; Clinically significant bacteremia or fungemia within 7 days prior to Screening that has not been adequately treated, as determined by the investigator; Clinically significant bacterial, fungal, or viral pneumonia within 2 weeks prior to Screening that has not been adequately treated, as determined by the investigator; Excessive nausea/vomiting at Screening, as determined by the investigator, or an inability to swallow pills that precludes oral administration of the IMP; Any condition which, in the opinion of the investigator, would prevent full participation in this trial or would interfere with the evaluation of the trial endpoints; Related to allergies: Known hypersensitivity or allergy to the IMP, its metabolites, or formulation excipients like microcrystalline cellulose, mannitol, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol and talc; Allergy to sulfa drugs; Related to laboratory results: Creatinine clearance lesser than 30 mL/min, calculated using the Cockcroft-Gault method; AST/ALT higher than 3x ULN; Total bilirubin higher than 3x ULN.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-5qkck4	Transcutaneous electrical nerve stimulation and diathermy microwave effects in the menstrual cramps	Not yet recruiting	Intervention	2016-03-16	<NULL>	<NULL>	754	Transcutaneous electrical nerve stimulation and diathermy microwave effects in the primary dysmenorrhea: placebo-controlled clinical trail	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Cidade de São Paulo	Universidade Cidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5qkck4	<NULL>	Health women; 18 to 44 years; no previous pregnancy; no physical activity; body mass index &lt;29.9 kg/m²; and had regular menstrual cycles, mild to moderate or severe menstrual cramps.	"hormonal contraceptives use; anti-inflammatory and/or analgesics for the treatment of menstrual cramps or any dysfunction;
diabetes; rheumatic arthritis; gynecological diseases; presence of malignant or benign tumor; metal implants; cardiac diseases; pacemaker use; decreased or absence of sensitivity in the abdominal region; and epilepsy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-4d6n9r	Analysis of genetic information from men with and without varicocele	Not yet recruiting	Observational	2016-03-18	<NULL>	<NULL>	758	Sperm transcriptome profile in men with and without varicocele	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Faculdade de Medicina de Ribeirão Preto	Centro Regional de Hemoterapia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4d6n9r	<NULL>	"Study group: men that have varicocele in grades II and III; aged between 18 and 45 years; not having done previous surgery correction of the disease.
Control groups: men aged between 18 and 45 years; fertility proven by having at least two children; and selected men from couples with infertility for male factor or unexplained infertility."	Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-76cwjd	An Efficacy and Safety Study of JNJ- 56021927 (ARN-509) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy	Not yet recruiting	Intervention	2016-03-30	<NULL>	<NULL>	773	56021927PCR3003 - A Randomized, Double-blind, Placebocontrolled Phase 3 Study of JNJ- 56021927 in Subjects with High-risk, Localized or Locally Advanced Prostate Cancer Receiving Treatment with Primary Radiation Therapy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-12-15	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-76cwjd	<NULL>	Inclusion Criteria:Age &gt;= 18 years; Indicated and planned to receive primary radiation therapy for prostate cancer; Histologically confirmed adenocarcinoma of an intact prostate, and 1 of the following at diagnosis: 1) Gleason score &gt;=8 and &gt;=cT2c, 2) Gleason score &gt;=7, PSA &gt;=20 nanogram per mililiters (ng/mL), and &gt;=cT2c; Charlson comorbidity index (CCI) &lt;=3 - An Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) grade of 0 or 1; Adequate liver function: aspartate aminotransferase (AST), alanine aminotransferase (ALT), &lt;2 * upper limit of normal (ULN) and total bilirubin &lt;1.5 * ULN - Participants who are sexually active (even men with vasectomies) and willing to use a condom and agree not to donate sperm during the trial ; Signed, written, informed consent; Be able to swallow whole study drug tablets	"Exclusion Criteria:Presence of distant metastasis, including pelvic nodal disease below the iliac bifurcation &gt;2 cm in the short axis - Prior treatment with GnRH analogue or anti-androgen or both for &gt;3 months prior to randomization - Bilateral orchiectomy 
; History of pelvic radiation; Prior systemic (eg, chemotherapy) or procedural (eg, prostatectomy, cryotherapy) treatment for prostate cancer; History of seizure or condition that may predispose to seizure (including, but not limited to prior stroke, transient ischemic attack or loss of consciousness &lt;= 1 year prior to randomization; brain arteriovenous malformation; or intracranial masses such as schwannomas and meningiomas that are causing edema or mass effect); Prior treatment with enzalutamide, abiraterone acetate, orteronel, galeterone, ketoconazole, aminoglutethimide, estrogens, megestrol acetate, and progestational agents for prostate cancer; Prior treatment with radiopharmaceutical agents (eg, strontium-89) or immunotherapy (eg, sipuleucel-T) for prostate cancer; Prior treatment with systemic glucocorticoids ?4 weeks prior to randomization or is expected to require long-term use of corticosteroids during the study; Use of 5-alpha reductase inhibitors (eg, dutasteride, finasteride) &lt;=4 weeks prior to randomization; Use of any investigational agent &lt;=4 weeks prior to randomization; Current chronic use of opioid analgesics for &gt;=3 weeks for oral or &gt;7 days for non-oral formulations; Major surgery &lt;=4 weeks prior to randomization; Current or prior treatment with antiepileptic medications for the treatment of seizures;  Gastrointestinal conditions affecting absorption; Known or suspected contraindications or hypersensitivity to JNJ-56021927, bicalutamide or GnRH agonists or any of the components of the formulations - Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-774vv2	"A multicenter, randomized, double-blind study,
to verify whether the treatment with dextrocetamina association with clonidine in the form of cream for application to the skin is superior to placebo (cream without any drug) in the treatment of neuropathic pain."	Not yet recruiting	Intervention	2016-03-31	<NULL>	<NULL>	775	A multicenter randomized, double blind, placebo controlled study to determine the efficacy and safety of dextro-ketamine 1% in combination with clonidine 0.03% topical gel cream in the treatment of neuropathic pain syndromes.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-01-16	Faculdade de Medicina do ABC	Cristalia Produtos Químicos Farmacêuticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-774vv2	<NULL>	Signed and dated informed consent form. Male or female patients of any ethnic origin aged 18 years or over. Outpatient status. Patients with diagnosis of neuropathic pain associated with diabetic peripheral neuropathy (DPN), post herpetic neuralgia (PHN), post traumatic or post operative peripheral neuropathy and leprosy; DPN defined as peripheral, somatic or autonomic nerve damage attributable solely to diabetes mellitus; PHN defined as pain lasting longer than three months beyond the crusting of the skin lesions after an acute attack of Herpes zoster.Patients with moderate to severe pain all or most of the time, that has persisted for three months or longer (for patients with post herpetic neuralgia pain present for more than three months after healing of Herpes zoster skin rash. Patients with DN4 score 4. Patients with pharmacological therapies for neuropathic pain [anticonvulsants, selective and non- selective serotonin reuptake inhibitors, antidepressants, gabapentoids, nonsteroidal anti-inflammatory drugs (NSAIDS), salicylates, or acetaminophen] should be dose stabilized for at least 14 days before randomization and be willing to maintain therapy constant, avoid changes, or initiate new therapies throughout the study. Patients with normal cognitive and communicative ability as judged by clinical assessment and ability to complete self-report questionnaires. Women of childbearing potential must have a negative urine pregnancy test before randomization and must be using and willing to continue using adequate contraception (hormonal, double barrier or intrauterine device, according to medical indication) or be sexually abstinent during the study, and must not be lactating. Post-menopausal women for less than two years are considered of childbearing potential.	"Patients with severe pain associated with conditions other than diabetic peripheral neuropathy, post herpetic neuralgia, leprosy and post traumatic or post operative peripheral neuropathy [e.g., significant vasculitis, collagen vascular disorder, familial neuropathy, alcoholism, pernicious anemia, hepatitis, malignancy, syphilis, chronic inflammatory demyelinating polyradiculopathy, human immunodeficiency virus (HIV), medication-induced neuropathy, vitamin B12 deficiency, and others]. Patients with other sustained pain with intensity at, or greater than neuropathic pain. Patients with major depression requiring treatment. Patients with known allergy to clonidine or ketamine. Patients with ongoing use of a monoamine oxidase inhibitor. Patients with current use of antiarrhythmic drugs of class one (sodium channel blockers). Patients with uncontrolled diabetes mellitus (fasting blood glucose ? 130 mg/dL) or uncontrolled hypertension (systolic blood pression ? 180mmHg or diastolic ? 110mmHg). Patients using implanted medical device (e.g., spinal cord stimulator, intrathecal pump, or peripheral nerve stimulator) for pain treatment. Patients clinically hypotensive with a resting diastolic blood pressure &lt;60 mm Hg or a systolic blood pressure &lt;90 mm Hg.
Patients with diagnosis of any significant or unstable medical or psychiatric condition that would interfere with their ability to participate in the study. Patients with history of substance abuse disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) within the previous year. Patients with symptomatic or severe coronary insufficiency, clinically significant, cardiac conduction disturbances, myocardial infarction (within last 12 months), moderate to severe cerebrovascular disease, or severe chronic obstructive pulmonary disease (COPD) requiring oxygen therapy. Patients with serum creatinine value &gt;2 times the upper limit of normal or values for alanine transaminase (ALT) or aspartate transaminase (AST) &gt;2.5 times the upper limit of normal at screening. Patients treated with ketamine or clonidine oral, transdermal patch, or topical gel over the last four weeks prior to the screening visit.
Patients that used any topically applied pain medication within a period of 7 days before the screening. Patients with evidence of clinically significant peripheral vascular disease as evidenced by history of intermittent claudication or evidence of vascular ulcers, including venous stasis ulcers. Patients receiving any medications that could affect neuropathic pain not at stable dose for at least 14 days prior to the screening visit (other than medications containing NSAIDs and aspirin which must be stable for seven days prior to the screening visit). Patients receiving complementary therapies (acupuncture, TENS, central blockage)and/or &quot;alternative medicines&quot; (naturopathy, homeopathy, etc.) for pain treatment of 7 days prior to the screening visit. Patients with history of malignancy within the previous five years. Patients that have been hospitalized within 30 days of the screening visit, or planning to have a surgery during the study period. Patients with any dermatologic condition that could affect study drug absorption. Patients carrying pacemaker, impantable cardiac defibrillator, or cardiac resynchronizer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-6txnfv	"A Study of JNJ-56021927 Plus Androgen
Deprivation Therapy (ADT) Versus ADT in
Participants with Low-Volume mHSPC"	Not yet recruiting	Intervention	2016-04-01	<NULL>	<NULL>	777	56021927PCR3002 - A Phase 3 Randomized, Placebocontrolled, Double-blind Study of JNJ-56021927 Plus Androgen Deprivation Therapy (ADT) Versus ADT in Subjects with Low-volume Metastatic Hormonesensitive Prostate Cancer (mHSPC)	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-11-20	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-6txnfv	<NULL>	Adenocarcinoma of prostate; if diagnosed greater than or equal to (&gt;=) 5 years from randomization; Metastatic disease documented by &gt;= 2 bone lesions on 99mTc bone scan; Eastern Cooperative Oncology Group Performance Status (ECOG PS) grade of 0, 1, or 2; Allowed prior treatment for prostate cancer: a) Maximum of 1 course of radiation or surgical intervention; b) Up to 6 cycles of docetaxel for low-volume disease with the last dose within 2 months of randomization; c) Must not have experienced disease progression between the last dose of docetaxel and Screening; Participants who did not receive prior docetaxel may have received less than or equal to (&lt;=) 3 months of ADT in the metastatic disease setting prior to randomization. Participants who received prior docetaxel may have received &lt;= 6 months ADT in the metastatic setting prior to randomization; May also have received up to 6 months of GnRHa in the adjuvant or neo-adjuvant setting as long as it was completed greater than (&gt;)1 year prior to randomization; May have received radiation therapy or prostatectomy as definitive therapy	Pathological finding consistent with small cell, ductal or neuroendocrine carcinoma of the prostate - Known brain metastases - Lymph nodes as only site of metastasis – Visceral metastasis observed on computed tomography (CT)/magnetic resonance imaging (MRI) or &gt;= 4 bone lesions on 99mTc bone scan with at least 1 lesion beyond the pelvis or vertebral column - Any prior malignancy within 5 years prior to randomization with the exception of squamous or basal cell skin carcinoma or non-invasive superficial bladder cancer - Prior treatment with other second generation anti-androgens or other CYP17 inhibitors, immunotherapy or radiopharmaceutical agents for prostate cancer - History of seizures or  medications known to lower seizure threshold	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-6q5rd5	The impact of dogs therapy for children with cancer	Not yet recruiting	Intervention	2016-04-18	<NULL>	<NULL>	803	The impact of the Animal Assisted Therapy (AAT) in oncological pediatric patients on physiological and psychosocial variables	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Fundação Pio XII	Fundação Pio XII	https://ensaiosclinicos.gov.br/rg/RBR-6q5rd5	<NULL>	Children of both sexes; 6 to 12 years old; diagnosis of a solid tumor; current diagnosis or relapse less than six months; with good clinical condition; signature of the Terms of Consent and Assent.	"Exclusion Criteria (study): children did not identify with the TAA; with serius mental problems what can cause an accident with the animal; no conclusion of the TAA program; incomplete answers to questionnaires applied; to allergic animals.

Exclusion criteria for the sessions: isolation precaution; presence of wound surgical; use of invasive device; presence of ostomy; neutropenia; fever; diarrhea; vomiting; respiratory symptoms; being hospitalized."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-5dm7g2	Study to evaluate the efficacy and safety of the implant of Cerebral Hypothermia Exclusive by Nasopharyngeal (posterior region of the nose) Catheter use to Treatment of severe Head trauma	Not yet recruiting	Intervention	2016-04-25	<NULL>	<NULL>	807	Efficacy and Safety of Hypothermia Cerebral Exclusive deployment through the use of catheter Nasopharyngeal in Human Beings for the treatment of seriuos (ou (severe) brain trauma Phase I Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dm7g2	<NULL>	Patients both male and female aged 18 to 70 years; Confirmed diagnosis of TBI; Glasgow Coma Scale 8; Use of definitive airway devices (tracheal tube, tracheostomy or cricotireoideostomia); Ssaturation of oxygen (O2) blood above 92%; Monitoring Indication of PIC by the neurosurgery team responsible for the case; patients, or their legal representatives who signed the informed consent.	Patients with early brain temperature &lt;35.5 ° C; Pregnancy known or obvious; Obstructive lesions of the upper airways; Confirmed diagnosis of skull base fracture or cerebrospinal fluid leaks evident nasally; Diagnosis cervical spine fracture confirmed with contraindications to cervical mobilization, even with the use of cervical collar; Blood Pressure 6-average &lt;65 mmHg in the last two hours; Use of antibiotics in the last two hours or signs of current infection or sepsis; Known use of anticoagulants in therapeutic dose; Bleeding not controlled; Signs of brain death or borderline flow by transcranial Doppler (TCD); Glasgow Coma Scale 3 associated with pupils without photoreaction; Current participation in another clinical study in progress.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-29grfm	Study to evaluate the response to treatment with the medication pasireotide LAR and the expression of the substances AIP and miR-34a in patients with acromegaly	Not yet recruiting	Intervention	2016-04-25	<NULL>	<NULL>	809	Prospective, non-randomized, phase II study to assess the AIP and miR-34a expressions and the response to pasireotide LAR treatment in acromegaly patients	<NULL>	2, single-arm-study, n/a	2	<NULL>	<NULL>	<NULL>	2016-06-01	Faculdade de Medicina - Universidade Federal do Rio de Janeiro (UFRJ)	Faculdade de Medicina - Universidade Federal do Rio de Janeiro (UFRJ)	https://ensaiosclinicos.gov.br/rg/RBR-29grfm	<NULL>	Age between 18 and 80 years; clinical indication of surgery as part of the treatment; laboratory and clinical confirmation of acromegaly; Signature of written informed consent.	"Contraindications to surgery due to high surgical risk; Previous radiotherapy for pituitary adenoma treatment; Presence of AIP mutation; Medical treatment with somatostatin analogues, dopamine agonists or GH antagonist before surgery; Patients with compression of the optic chiasm causing any visual field defect that requires surgical intervention; Diabetic patients with poor glycaemic control as evidenced by HbA1c &gt;8%; Patients with symptomatic cholelithiasis and acute or chronic pancreatitis; Patients with risk factors for torsade de pointes, i.e. patients with a baseline QTcF &gt;450 ms in males, and &gt;460 ms in females; Hypokalaemia, hypomagnesaemia, uncontrolled hypothyroidism, family history of long QT syndrome or concomitant medications with known risk of Torsades de pointes (TdP); Patients who have congestive heart failure (NYHA Class III or IV), unstable angina, sustained ventricular tachycardia, clinically significant bradycardia, advanced heart block, history of acute myocardial infarct less than one year prior to study entry or clinically significant impairment in cardiovascular function; Concomitant disease(s) that could prolong the QT interval such as autonomic neuropathy (caused by diabetes or Parkinson’s disease), HIV, cirrhosis, uncontrolled hypothyroidism or cardiac failure; Patients with liver disease such as cirrhosis, chronic active hepatitis, or chronic persistent hepatitis, or patients with ALT/AST &gt; 2.0 X ULN, serum bilirubin &gt;2.0 X ULN; Presence of Hepatitis B surface antigen (HbsAg) or Hepatitis C antibody test (anti-HCV); Patients with serum creatinine &gt;2.0 X ULN; Patients with white blood cells &lt;3 X 109/L; Hb 90% &lt; LLN; Platelets &lt;100 X 109/L; Patients with active malignant disease in the last five years (with the exception of basocelular carcinoma or in situ cervix carcinoma); Patients with the presence of active or suspected acute or chronic uncontrolled infection; Patients who have undergone major surgery/surgical therapy for any cause within 4 weeks prior screening; Patients with abnormal coagulation (PT and/or APTT elevated by 30% above normal limits) or patients receiving anticoagulants that affect PT (prothrombin time) or APTT (activated partial thromboplastin time); History of syncope or family history of idiopathic sudden death; History of immunocompromise, including a positive HIV test result (ELISA and Western blot); known hypersensibility to somatostatin analogs or any other component of pasireotide; Sexually active males unless they use a condom during intercourse while taking drug and for 3 months following last dose of pasireotide and should not father a child in this period. A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid; Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test; Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and 3 months following last dose of pasireotide. Highly effective contraception methods include: abstinence (when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception; Female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy) or tubal ligation at least six weeks before taking study treatment. In case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment; Sterilization (at least 6 months prior to screening). For female subjects on the study the vasectomized male partner should be the sole partner for that subject; Combination of any two of the following: Use of oral, injected or implanted hormonal methods of contraception or other
forms of hormonal contraception that have comparable efficacy (failure rate &lt;1%), for example hormone vaginal ring or transdermal hormone contraception; Placement of an intrauterine device (IUD) or intrauterine system (IUS); Barrier methods of contraception: Condom or Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal suppository; In case of use of oral contraception women should have been stable on the same pill for a minimum of 3 months before taking study treatment; Women are considered post-menopausal and not of child bearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy) or tubal ligation at least six weeks ago. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment is she considered not of child bearing potential."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-2dwhkm	Effects of a technique using apparatus and one using manual technique both for removal of bronchial secretions in hospitalized children.	Not yet recruiting	Intervention	2016-04-27	<NULL>	<NULL>	816	Effects of a new vibrotherapy instrument &quot;Pulsar&quot; and vibro in children in the hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-2dwhkm	<NULL>	Both genders; aged between 29 days to 3 years old; who require respiratory therapy in the first 48 hours of hospitalization.	Clinical situations that respiratory physiotherapy this contraindicated as bleeding with hemodynamic instability, intracranial pressure higher than 20 mmHg; chest tube; pneumothorax; open wounds and chest skin infections; osteomyelitis of the ribs; osteoporosis and rib fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-5r8syp	Effect of nursing care on prevention of dry eye in adult patients admitted to the Intensive Care Unit	Not yet recruiting	Intervention	2016-04-29	<NULL>	<NULL>	822	Randomized clinical trial: effect of nursing interventions on prevention of dry eye in critically ill patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Escola de Enfermagem da Universidade Federal de Minas Gerais	Santa Casa Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5r8syp	<NULL>	"Be over 18 years;
did not present dry eye at the time of admission;
stay in the ICU for at least 24 hours;
be in mechanical ventilation therapy;
glance less than 5 per minute;
comatose, sedated or Glasgow less than or equal to 7; 
consent to participate in research or have."	"Have not the responsabille authorization;
Patients with severe eye disease or with history of adverse effects after use of any of the interventions proposed and not tolerate the treatment: artificial tear gel, artificial tear liquid and saline 0.9%."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-5497s9	Clinical study to assess the safety, and tolerability of multiple doses of orally administered JNJ-53718678 in infants hospitalized with RSV infection	Not yet recruiting	Intervention	2016-05-05	<NULL>	<NULL>	837	53718678RSV1005 - A Phase 1b, randomized, partially doubleblind, placebo-controlled study to assess the pharmacokinetics, safety, and tolerability of multiple doses of orally administered JNJ-53718678 in infants hospitalized with RSV infection	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2015-11-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP-USP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-5497s9	<NULL>	Inclusion Criteria: Participant has presented at the hospital for suspected Respiratory Syncytial Virus (RSV) infection within 72 hours prior to Screening completion; Participant has been hospitalized for this suspected RSV infection; Participant has been diagnosed with RSV infection using a polymerase chain reaction (PCR)-based assay, preferably commercially available locally; Participant was born after a normal term pregnancy (greater than or equal to 37 weeks and 0 days); A legally acceptable representative of the participant must sign an Informed consent form (ICF) indicating that he or she understands the purpose of and procedures required for the study, are willing for their child to participate in the study, are willing for their child to remain in the hospital for the first 3 days of dosing (even if not clinically indicated), and are willing/able to adhere to the prohibitions and restrictions specified in the protocol and study procedures	Exclusion Criteria: Participant who had major surgery within the 28 days prior to randomization or planned major surgery through the course of the study; Participant has major congenital anomalies or known cytogenetic disorders; Participant has known or suspected immunodeficiency, such as known human immunodeficiency virus (HIV) infection; Participant has known or suspected hepatitis B or C infection; Participant is upon current admission initially hospitalized in the Intensive care unit (ICU) and/or in need of invasive endotracheal mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-43v3tk	Orthoses for thumb osteoarthritis: a functional and kinematic analysis	Not yet recruiting	Observational	2016-05-06	<NULL>	<NULL>	838	The Use of Orthotics for Thumb Osteoarthritis: Kinematic and Functional Analysis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Universidade de Brasília - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-43v3tk	<NULL>	Subjects diagnosed with osteoarthritis of the thumb joint carpometacarpia, via radiographic and clinical indicative suggested by the American College of Rheumatology. Will be included subject  with osteoarthritis severity between rates 1 and 3 in the Radiographic Kellgren-Lawrence, corresponding to mild to moderate disease status. Inclusion criteria also will consider patients over 18 years, with no age  limit and subjects who present no cognitive limitations that prevent them from answering the Health Assessment Questionnaire, a self administered instrument that assesses the degree of difficulty in performing activities of daily living.	Subjects withupper limb pain or functional limitations. Subjects with thumb OA in stage 4 of Kellgren-Lawrence Radiographic Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-8m6dt4	Effects of physiotherapy followed by the motor imagery on the mobility of patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2016-05-10	<NULL>	<NULL>	842	Repercussions of motor training followed of mental practice in functional mobility of patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-08	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8m6dt4	<NULL>	Patients with clinical diagnosis of idiopathic Parkinson&apos;s disease; aged between 45 and 75 years; of both sexes; in stage 1-3 of the Hoehn and Yahr scale (HY); they are research volunteers.	Patients with other neurological diseases; patients reporting uncompensated systemic diseases (untreated), such as hypertension; with compromised cognitive level assessed by the Mini-Mental State Examination (MMSE); unsatisfactory motor imagination assessed by questionnaire Visual Imagery and Kinesthetic (KVIQ-20); in physical therapy service for 3 months or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-468wm2	Effect of interventions on the quality of sleep and stress in people with Diabetes	Not yet recruiting	Intervention	2015-12-09	<NULL>	<NULL>	848	"Effect of non-pharmacological interventions on the quality of sleep and stress
emotional in people with Type 2 Diabetes Mellitus"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-468wm2	<NULL>	People with Type 2 Diabetes Mellitus in clinical follow-up in that service; aged greater than 18 years; both sexes; who have active telephone contact; not forming any pharmacological / non-pharmacological treatment for improving sleep quality or that interferes it.	People that are experiencing cognitive impairment , according to an evaluation of the Mini -Mental State Examination ( MMSE), according to the educational tracks; People who submit total score on the Pittsburgh Sleep Quality Index (PSQI less than or equal to 5, defining them as &quot;good sleepers&quot;); Night Workers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-5tt55v	Flower Essences in relieving anxiety during labor.	Not yet recruiting	Intervention	2016-05-19	<NULL>	<NULL>	853	Flower essences : effects on anxiety during  labor pain.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Escola Paulista de Enfermagem-Universidade Federal de São Paulo	Secretária Municipal de Saúde de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-5tt55v	<NULL>	Do not have obstetric pathologies; Being in the active phase of labor, diagnosed on admission by the treatment team minimum 3 cm cervical dilatation and maximum of 8 cm; term gestational age between 37 and 42 completed weeks calculated by last menstrual period and  or the result of early ultrasound, that is held up to 20 weeks; Minimum age of 18 years; pregnancy with a single fetus alive.	Smokers who has smoked less than two hours after nicotine influence on catecholamine secretion; Bearers of mental disorders, documented in the medical record, which would influence his decision and autonomy; They reported having ingested caffeine in the last 10 hours, thus altering the secretion of catecholamines; Users of psychoactive drugs, which influence his decision and autonomy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-94bvrc	Oral cleaning in intensive care unit patients with photodynamic therapy	Not yet recruiting	Intervention	2016-06-08	<NULL>	<NULL>	885	Oral hygiene in intensive care unit patients  using photodynamic therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-94bvrc	<NULL>	Intensive care unit patient with 0 to 24h oro-tracheal intubation; patients whose family agree with the participation on this study and sign the agreement term; both genders, above 18 years old	Reintubation; readmission in Intensive Care Unit (ICU); smokers and ex-smokers for less than 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-2fvdg2	The Brief Intervention to alcohol related disorders on university servers	Not yet recruiting	Intervention	2016-06-14	<NULL>	<NULL>	887	Effects of Brief Intervention (BI) to alcohol related disorders on university servers: a quantitative and qualitative analysis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	(FAPEMIG) - Fundação de Amparo à Pesquisa do Estado de Minas Gerais	Laisa Marcorela Andreoli Sartes	https://ensaiosclinicos.gov.br/rg/RBR-2fvdg2	<NULL>	IT will be included in the study individuals who are over 18, university servers, who accept taking part of it and signing the Agreement and Informed Consentment.	It will defined as non-inclusion criteria for this study people who use other drugs besides than alcohol and tobacco, university professors, outsourced employees who have no permanent position in the institution and individuals unable to answer the questionnaire at the time of reserch application. These individuals will be invited to participate in the survey but they will excluded for data analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-3hzdgv	Monitoring Overweight women by Nursing Telephone Assistance	Not yet recruiting	Intervention	2016-06-16	<NULL>	<NULL>	894	Monitoring of Overweight women by Nursing Remote Assistance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Escola de Enfermagem da Universidade Federal da Bahia	Catia Suely Palmeira	https://ensaiosclinicos.gov.br/rg/RBR-3hzdgv	<NULL>	Women with a body mass index greater than or equal to 25 kg / m2; who have made at least one visit in the last twelve months; and who have home or mobile phone.	Women without physical conditions like amputations for weight and height measurements; with mental confusion; in cognitive conditions that prevent them from responding questionnaires and reading text messages; diagnosed with severe psychiatric disorders; using drugs for weight loss and undergoing bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-4k9m6g	Effects of mobilization and muscle strengthening of neck in neck pain	Not yet recruiting	Intervention	2016-06-24	<NULL>	<NULL>	899	Effects of association between Mobilization and Segmental Stabilization Cervical in function, range of motion, and strenght of patients with Chronic Neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4k9m6g	<NULL>	chronic neck pain and cervical radiculopathy; aged 30 to 50 years; and patients signed a free and clarified	patients with cervical spine surgery; concomitant treatment for neck pain; neuromuscular disorders; neurological diseases; pregnant patients; smokers and patients with cognitive problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-9cph2q	Anxiety in musicians and recognition of the face&apos;s emotions: study about the possible effects of oxytocin.	Not yet recruiting	Intervention	2016-06-29	<NULL>	<NULL>	902	Musical performance anxiety and recognition of facial expressions: clinical randomized study involving the general population and acute effects of oxytocin	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Medicina de Ribeirão Preto - USP	Flávia de Lima Osório	https://ensaiosclinicos.gov.br/rg/RBR-9cph2q	<NULL>	Age above 18 years; Male sex; Professional activities or amadora as a musician, with frequent public presentations at significant audiences.	Neurological and / or psychiatric disorders, excluding anxiety disorders; Renal, pulmonary, hepatic and / or cardiovascular diseases; Current use of tobacco, psychoactive substances and any kind of medication; Harmful alcohol use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-52hbf7	Comparison of long-term effects of the technique with contraction of the belly muscles and stretching in patients with back pain	Not yet recruiting	Intervention	2016-07-04	<NULL>	<NULL>	909	Comparison of long-term effects of segmental stabilization technique and stretching in patients with low back pain chronic nonspecific	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal do Amapá - Unifap	Universidade Federal do Amapá - Unifap	https://ensaiosclinicos.gov.br/rg/RBR-52hbf7	<NULL>	For the study are included patients aged 18 to 65 years; patients with a diagnosis of non-specific low back pain with at least three months of progression of pain; patients who signed the informed consent and informed	"Patients pregnant women; patients with specific diagnosis that cause low back pain;
orthopedic, rheumatic and neurological problems; nerve root injury; patients with impaired cognition; patients undergoing treatment during the study period; patient who underwent pre-treatment at least 3 months"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-2st594	Integrated design : characterization of children with neurological disorders who perform physiotherapy	Not yet recruiting	Intervention	2016-07-15	<NULL>	<NULL>	925	Integrated design: user characterization and effects of neuromotor intensive therapy  and aquatic physical therapy in children with neuromotor disorders	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-14	Universidade Federal do Paraná	Instituto Brasileiro de Therapias e Ensino (IBRATE)	https://ensaiosclinicos.gov.br/rg/RBR-2st594	<NULL>	clinical diagnosis of pathology that causes motor neurone disorder such as cerebral palsy syndromes or delays in motor development ; medical indication for the procedure; age 0-18 years; both sexes ; with consent by parents and / or family	subluxation of the hip ; acute fractures ; severe scoliosis ; uncontrolled seizures ; serious intellectual delay ; spasticity with severe angle &gt; 35; contractures or other congenital deformities ; intrathecal baclofen pump ; autism; encephalopathies progressive , psychiatric disorders ; myopathies ; Botox use with time of less than 3 months and surgeries with time less than 1 year ; for patients who will be added to the aquatic therapy earlier , lack of sphincter control ; injuries and / or skin disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-4ykn3p	Quality of life of people with eye disease elevated intraocular pressure and knowledge about the disease before and after practice health education	Not yet recruiting	Intervention	2016-07-18	<NULL>	<NULL>	929	Glaucomatous life quality and knowledge about the disease before and after practice health education	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Unimontes	Santa Casa Olhos de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-4ykn3p	<NULL>	glaucomatous with 40% accuracy in disease knowledge questionnaire; reside in Montes Claros; both genders; aged between 18 and 70 years.	glaucomatous unable to answer an evaluation questionnaire of knowledge about the disease; mental impairment with cognitive impairment; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-7t8fv7	Clinical trial of the effectiveness of telephone nursing care to individuals with inflammatory bowel disease	Not yet recruiting	Intervention	2016-07-25	<NULL>	<NULL>	937	The telenursing in the treatment of inflammatory bowel diseases: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Policlínica Piquet Carneiro da Universidade do Estado do Rio de Janeiro	Policlínica Piquet Carneiro da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7t8fv7	<NULL>	volunteer with Crohn disease in remission and light activity; volunteer with ulcerative colitis in remission and light activity; both genders; aged between 18 and 60 years.	volunteers with cognitive disorder; volunteers without acess to phone; volunteers with special needs that preclude the telenurssing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-7sm6qj	The use of educational game as a strategy to confront the childhood obesity	Not yet recruiting	Intervention	2016-07-27	<NULL>	<NULL>	942	"The use of serious games as a strategy to confront the childhood obesity:
randomized clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-30	Escola de Educação Física e Esporte de Ribeirão Preto	Escola Enfermagem de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7sm6qj	<NULL>	aged 8-14 years; with body mass index (BMI) percentile 85; allowed to play video games; who can read; that are being followed in an outpatient clinic obesity.	with Diabetes Mellitus or celiac disease; who have arthritis; that have hormonal dysfunctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-2kw6p9	Use of equine therapy to improve his breath, heartbeat, balance and muscle in elderly patients	Not yet recruiting	Intervention	2016-08-01	<NULL>	<NULL>	945	Use of hippotherapy as a tool in the improvement of blood oxygenation, heart rate variability, balance and muscle activation frequency in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal do Triângulo Mineiro	Associação de Pais e Amigos dos Excepcionais de Uberaba - APAE	https://ensaiosclinicos.gov.br/rg/RBR-2kw6p9	<NULL>	Medical referral; signing the liability waiver for the practice of hippotherapy; healthy volunteers without acute diseases, both genders, aged 60 years.	Uncontrolled epilepsy; acute diseases; uncontrollable fear or self-destructive behavior; instability of the spine; severe cervical spine conditions like herniated disc; dislocations of the shoulder or hip; evolving scoliosis 30 degrees or more; hydrocephalus valve; arthritic processes in acute phase; decubitus ulcers in the pelvic region or lower limbs and other diseases that can compromise data analysis; and that is not performing any physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-6brs8b	Study of the visual field of patients treated with the intraocular medication ranibizumab on the disease retinal vein occlusion of the retina.	Not yet recruiting	Intervention	2016-08-03	<NULL>	<NULL>	947	Perimetrical Findings in the double frequency perimetry (PDT) in the treatment of branch vein with Lucentis (Ranibizumab)	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal do Espirito Santo	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6brs8b	<NULL>	Patients with Branck Retinal Venous occlusion (BRVO) with acute edema that started between 0 and 6 months; visual acuity between 20/40 and  20/400; Central foveal thickness greater than 250 microns , measured in optical coherence tomography (OCT); Age of 18 years or more; Subjects who agreed and signed an informed consent form.	Concomitant Conditions in the study eye that can, in the opinion of investigator, hinder the improvement of visual acuity with the proposed treatment; Opacities of ocular environment; Active intraocular inflammation (inflammation trace degree or above) in any eye; Any active infection (eg conjunctivitis, keratitis, scleritis, uveitis, endophthalmitis.) In either eye; Previous history of uveitis in either eye; Structural damage in the macula in one of the macula center diameter disc in the study eye, which can prevent improvement in visual acuity after resolution of macular edema, including atrophy of the retinal pigment epithelium, subretinal fibrosis, scar (s) by laser or hard exudates arranged in the plate; Eye diseases in the study eye that can confuse the interpretation of the study results, compromising visual acuity or require medical or surgical intervention during the period of 6 months of the study, including retinal detachment, macular hole or choroidal neovascularization of any cause (eg macular disease related to age, ocular histoplasmosis or pathological myopia.); Glaucoma not controlled in the study eye (according to the investigator&apos;s judgment); Retinal neovascularization in the eye of the study;  Previous episode of retinal vein occlusion in the study eye;  afferent pupillary defect.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-6j3x5q	Clinical evaluation of restorations carried out on newly whitened teeth	Not yet recruiting	Intervention	2016-08-25	<NULL>	<NULL>	974	Clinical evaluation of an antioxidant on bond strength of esthetic restorations in newly whitened teeth	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-05	Universidade Estadual de Maringá	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6j3x5q	<NULL>	Volunteers with canines and upper and lower premolars with non-carious lesions of abfraction, abrasion and erosion featuring color change A3 or higher by Vitapan scale; presenting at least 4 teeth on the sample, so that each tooth represents one of the groups; have at least 20 teeth in function and lesions that contain at least fifty percent of enamel margins.	Canines and bicuspids with endodontic treatment; who do not have the need to be restored; which suffered action of bleaching agents previously; with periodontal disorders; with active caries; with changes in the formation of enamel.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-2dyf33	Fluoride varnish to prevent dental caries in primary teeth	Not yet recruiting	Intervention	2016-08-29	<NULL>	<NULL>	975	Effectiveness of fluoride varnish to prevent dental caries in primary teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Faculdade de Odontologia da Universidade do Oeste Paulista	Faculdade de Odontologia da Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2dyf33	<NULL>	"Children will be included from 1 to 4 years;
Which are classified in the A + risk B - / +, C - / +, D - / + and - / +, F - / + G - / +;
Which reside in the city of Presidente Prudente for at least one year;
Plan to live in the city for the next two years;
Who attend public schools;
And have the consent of parents or guardians."	"Children will be excluded classified A- risk;
Children who received professional application of fluoride in the last six months;
Which have more than ten carious lesions;
And are suffering from systemic disease that may aggravate oral problems or interfere with search results"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-4h97rb	Low Level Laser Therapy and exercise to patients with chronic pain and rheumatic diseases: randomized clinical trials with pain , quality of life, functionality assessments and biomechanical aspects.	Not yet recruiting	Intervention	2016-09-12	<NULL>	<NULL>	994	Low Level Laser Therapy and exercise to patients with chronic pain and rheumatic diseases: randomized clinical trials with pain , quality of life, functionality assessments and biomechanical aspects.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Universidade de Brasília	Centro Universitário Unieuro	https://ensaiosclinicos.gov.br/rg/RBR-4h97rb	<NULL>	Being older than 18 years; To track across at least one of the clinics, with diagnosis made by the medical staff; Be able to fill out the consent form and clear.	Having the diagnosis of acute pain; severe psychiatric disorder; Diagnosis of chronic infectious disease; acute or chronic underlying disease with a high probability of death soon; exercise performance or other intensive treatment for pain for up to 48 hours of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-4wk4b3	Influence of an exercise program on cardiac function of patients with Stroke.	Not yet recruiting	Intervention	2016-09-19	<NULL>	<NULL>	1008	Influence of an exercise program on cardiac remodeling and functional capacity of patients with Stroke.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Faculdade de Medicina de Botucatu (FMB) - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; (UNESP)	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4wk4b3	<NULL>	Will be included participants older than 18 years; both sexes; ischemic stroke or TIA; modified Rankin scale (mRS less or equal 2); chronic phase (6 to 12 months of the onset of symptoms); clinically stable for the study after medical approval.	Patients with hemorrhagic stroke; mRS more than 2; uncontrolled hypertension (systolic blood pressure more than 150 mm Hg); history of angina in the last three months; uncontrolled epilepsy; heart rate of persistent atrial fibrillation or permanent and/or rate of artificial pacemaker; presence of mitral and/or aortic valvular stenosis; presence of heart failure grade IV - stage D; chronic obstructive pulmonary disease (COPD); life expectancy less than 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-4br6q5	The effect of mindfulness meditation on crack cocaine users	Not yet recruiting	Intervention	2016-10-06	<NULL>	<NULL>	1029	Effectiveness  of  mindfulness-based  stress  reduction  as  an  adjuvant strategy for the 12 steps program in relapse prevention among crack cocaine users: a randomized clinical trial	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2016-10-05	Escola de Enfermagem de Ribeirão Preto	Escola de Enfermagem de Ribeirão Preto (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-4br6q5	<NULL>	Be followed up in the TC for at least 30 days (crack abstinent); be in treatment in the TC due to the problematic use of crack (self-reported and confirmed by a TC profissional); fill the substance disorder criteria of The Diagnostic and Statistical Manual of Mental Disorderss, 5th Edition (DSM-V) 31; and score greater than 25 on the Mini-Mental State Examination (MMSE)	Presence of psychotic symptoms reported by TC professionals or identified by the researcher during the interview to the randomization of the sample; and report health problem that prevents the collection of cortisol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-75s4sn	Intubation confirmation in newborns with volumetric device compared to the clinical method	Not yet recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1031	Neonatal intubation confirmation with the use of pedflow volumetric device and the clinical method	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-15	hospital das clínicas de pernambuco	hospital das clínicas de pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-75s4sn	<NULL>	newborns that in selected hospitals requiring intubation in presence one of the researchers	newborns weighing less than 500 grams , with genetic syndromes , poor facial formations or in use of neuromuscular paralytic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-86gd8n	Evaluation of Heart Rate With Equipment That Extends Sound of Heartbeats in Newborn in the Delivery Room	Not yet recruiting	Intervention	2016-10-14	<NULL>	<NULL>	1036	Evaluation of Heart Rate With Sonar in Newborn in The Delivery Room	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-86gd8n	<NULL>	Newborns with gestational age greater than or equal to 34 weeks, in which at least one of the researchers is present in their delivery.	Newborns with bad formation and those requiring positive pressure ventilation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-9p8whf	Exercise Effect On Balance And On Falls Risk Among The Elderly Living In The Community	Not yet recruiting	Intervention	2016-10-14	<NULL>	<NULL>	1038	Impact Of A Therapeutic Exercise Program On Physical And Functional Capacity And On Risk Of Falls Among Community Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade de Brasília	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-9p8whf	<NULL>	Elderly volunteers; aged 60 years; both sexes; residents in the community (non-institutionalized); with history of one or more falls in the previous year or at risk of falling; that agree to participate and sign the consent form.	Volunteers in bedridden or wheelchair situation; score less than 17 on the Mini Mental State; severe visual impairment; amputations or use of lower limb prostheses; neurological disease; acute crisis related to vestibular in the last month; history of recent fractures in the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-5fdph6	Effects of green tea on physical conditioning in young untrained	Not yet recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1042	Velocity of ventilatory anaerobic threshold and heart rate variability after acute supplementation of the main componets of green tea in young untrained: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5fdph6	<NULL>	Youngs of both genders, aged between 20-35, insufficient active by International Physical Activity Questionnaire (IPAQ)	"No additional orthopedic deficiencies impairing ambulation
Diabetic individuals
Individuals with cardiopathies
Individuals with body mass index maior que 30 Kg/m2
Regular caffeine or green tea drinkers
Individuals with intolerance to caffeine or green tea"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-9sp5hx	Program at school: Healthy Living, Happy Heart	Not yet recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1052	Promotion program for cardiovascular health: resources and interventions in the school network	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-04	Instituto de Cardiologia  - Fundação Universitária de Cardiologia	Instituto de Cardiologia  - Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9sp5hx	<NULL>	Children 6 to 11 years old, both genders, students from 1st to 5th grade of elementary school of public schools in the city of Frederick / RS; Children with permission of parents or guardians; Teachers and educators from public schools in the municipality of Frederick / RS representing school years 1st to 5th grade of elementary school.	Children older than 9 years who are illiterate; with cognitive or neurological deficits that prevent the completion of the questionnaires; Teachers who teach in more than one research participant school; and teachers who do not sign the Instrument of Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-95crtd	Effect of expanding motor opportunities at the home environment in  infants with risk for developmental delay	Not yet recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1053	Effect of a goal-oriented training with activities and toys at the home environment of infants with environmental and biological risks to delay on neuromotor development	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-30	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-95crtd	<NULL>	Infants with social and environmental risks; infants with biological risk; low socioeconomic status; low parental education; both gender; age at 6 to 8 months old.	Infants with adequate motor development; infants who do not appear in the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-7b399d	Training respiratory muscles really improves functional capacity in patients with spinal cord injury?	Not yet recruiting	Intervention	2016-10-27	<NULL>	<NULL>	1059	Effects of Inspiratory Muscle Training with Dynamic Resistance on Aerobic Capacity in Traumatic Spinal Cord Injury: Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-03	Rede Sarah de Hospitais de Reabilitação	Rede Sarah de Hospitais de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-7b399d	<NULL>	During a period of 10 to 12 months, we will select males; non-smokers; with traumatic SCI; with complete motor injury (ASIA A or B), between T4 and C5 levels; injured for more than 6 months; who are able to perform an arm crank exercise test in an upper limbs cyclergometer.  They will be admitted from Neurorehabilitation in spinal cord injury program from Sarah Network of Rehabilitation Hospitals Brasília.	Will not be included in the study patients with scheduled surgery; with known heart or lung diseases; athletes; or who presents acute infectious syndromes or with any clinical decompensation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-2rsxnc	Measures of indicators of attention and action expectancy during task acomplishment	Not yet recruiting	Observational	2016-10-31	<NULL>	<NULL>	1060	Attentional indicators between body action expectancy and selconsciousness in the performance in induced tasks	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-11-28	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2rsxnc	<NULL>	Right handed; both genders; normal or corrected to normal vision; and should not drink coffee or alcohool for up to 4 hours before the experiment	Have self report of psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-9y5fbs	Use of penile clamp and quality of life in urinary incontinence after prostate surgery	Not yet recruiting	Intervention	2016-11-01	<NULL>	<NULL>	1062	Use of the penile clamp and quality of life in Urinary Incontinence After Prostatectomy: clinical trial Phase I / II	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2017-01-15	Faculdade de Enfermagem da Universidade Estadual de Campinas	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9y5fbs	<NULL>	have stress urinary incontinence; have completed prostatectomy or transurethral resection for at least one year; have satisfactory score on the Mini Mental State Examination; have normal sensation in the perineum and the penis by physical examination; perineal intact skin; good manual dexterity demonstrated with installing and removing the clamp; to read and write or come with caregiver or family member, in the case of illiterate patients.	be performing radiotherapy or chemotherapy for prostate tumor; have symptoms of urge urinary incontinence or urge incontinence; prior urodynamic study demonstrating detrusor overactivity or low compliance; present neurological disorders or other conditions that alter the perineal sensitivity, manual dexterity or change in cognitive function; provide blood flow velocity in lower systolic peak 10ml per seconds in the flaccid penis; be in use of penile prosthesis; be in the presence of urinary tract infection, but after resolution of the urinary tract infection, may be part of the survey, provided it meets the other eligibility criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-94v6kd	Effects of Exercise of the Respiratory Muscles with Different Types of Devices in People with Chronic Obstructive Pulmonary Disease	Not yet recruiting	Intervention	2016-11-23	<NULL>	<NULL>	1076	Effects of Respiratory Muscle Training with Different Modalities in Patients with Chronic Obstructive Pulmonary Disease (COPD) - Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal  do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes - HUOL	https://ensaiosclinicos.gov.br/rg/RBR-94v6kd	<NULL>	Follow up with a specialized pulmonology physician, aged between 40 - 80 years, living in city of the study, not in use of oxigenoteraphy or disease exacerbation in the last three months, not practicing regular physical activity in the last six months will be eligible to participate.	Musculoskeletal comorbidities that interfere with the march ; which decreased the oxygen saturation ( SpO2) &lt;90 % during cardiopulmonary exercise testing ; who had difficulty intellectual understanding that prevented them from performing evaluation activities ; abandon the proposed therapeutic program ; missing the proposed activity over one week or they do not appear to the re-evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-46xf3w	The monitoring by nurses in controlling high blood pressure and preventing complications	Not yet recruiting	Intervention	2016-11-24	<NULL>	<NULL>	1078	Effect of case management on the control of blood pressure levels and Hypertension complications prevention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Programa de Pós Graduação em Enfermagem da Universidade Federal do Paraná	Secretaria Municipal de Saúde do Município de Dois Vizinhos	https://ensaiosclinicos.gov.br/rg/RBR-46xf3w	<NULL>	"Adults both sexes aged 18 to 58 years;
Have high blood pressure;
Living in the city of Two Neighbors, Paraná;
Be registered at the facility where they will be data collection;
Achieve the minimum score on the Mini-Mental State Examination;
Being partially dependent and independent
as the functional scale of instrumental activities of daily living."	"Pregnant women;
People planning to change your address to another coverage area or city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-26w4cr	Study of Psma radiopharmaceutical for diagnosis of prostate cancer recurrence	Not yet recruiting	Intervention	2016-12-01	<NULL>	<NULL>	1084	Evaluation of HBED-PSMA-Ga68 kits for prostate cancer biochemical recurrence diagnostic	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2017-01-01	MJM Produtos Farmaceuticos e de Radioprotecao Ltda	Real e Benemerita Associação Portuguesa	https://ensaiosclinicos.gov.br/rg/RBR-26w4cr	<NULL>	Volunteer 18 years of age or older submitted to curative treatment of prostate cancer. Prostatectomy and presenting biochemical prostate cancer recurrence. Indicating PSA&gt; 0.2 ng/ml level. Curative radiochemical therapy and presenting biochemical prostate recurrence. Indicating PSA&gt; 2.0 ng/ml. Result of at least one of the following exams. MDP-Tc-99m bone scintigraphy. Nuclear Magnetic Resonance. Computed Tomography, or Positron Emission Tomography with Fluordeoxiglucose-F-18. Being capable of understand and sign the informed consent.	Radiopharmaceutical therapy administered within four weeks or in a smaller time interval than five half-lives of the used agent. Active infection or fever not explained&gt; 38.5 ° C during screening visits or on the day of the examination. Known hypersensitivity to any of the components Ga-68. HBED-CC. PSMA or excipient of PSMAHBED DC-kit. Any other medical or social condition considered by the investigator prone to interfere with the patient&apos;s ability to sign the consent cooperate and participate in the study or interfere with the interpretation of the results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-7b9xff	Elderly health of the organization in public health in Montes Claros, Minas Gerais, Brazil	Not yet recruiting	Intervention	2016-12-06	<NULL>	<NULL>	1089	Matricial in elderly health in primary health of Montes Claros, Minas Gerais, Brazil	<NULL>	0, non-randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Estadual de Montes Claros, Unimontes	Universidade Estadual de Montes Claros, Unimontes	https://ensaiosclinicos.gov.br/rg/RBR-7b9xff	<NULL>	age between 60 and 115 years; elderly enrolled and followed in the Family Health Strategy; both genders.	inability to respond to the evaluation questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-6mpf4v	Evaluation of the macula by optical tomography through surgical mycoscope in patients with media opacities	Not yet recruiting	Observational	2016-12-16	<NULL>	<NULL>	1101	Evaluation by Optical Coherence Tomography Intraoperative through Rescan 700 coupled to OPMI Lumera 700 in patients with opaque media.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Instituto Brasileiro de Oftalmologia	Instituto Brasileiro de Oftalmologia	https://ensaiosclinicos.gov.br/rg/RBR-6mpf4v	<NULL>	Patients with patients with vitreous hemorrhage or cataract ;patients with vitreous hemorrhage without clinical improvement in 60 days when it was not possible to obtain images with OCT preoperatively;  patients with  associatedl vítreoretinal disease the presence of cataract indication of combined surgery ( cataract surgery and vitrectomy ) without preoperative OCT	Absence of posterior vitrectomy indication pars plana ;the presence of preoperative OCT in the last three months before surgery ;failure to obtain the images in the perioperative period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-753kcg	The effect of the operating group for care teaching with their feet to prevent risk of injuries on the feet of people with Diabetes.	Not yet recruiting	Intervention	2016-12-27	<NULL>	<NULL>	1119	The effect of the operating group for care teaching with your feet in the prevention of skin integrity impaired risk of the feet of people with diabetes mellitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-753kcg	<NULL>	People of both sexes with Diabetes Mellitus Type II diagnosed for at least five years; be registered in the Family Health Unit ; have the age of eighteen.	People of both sexes, with Type 1 Diabetes Mellitus; Presence of ulcers in the feet; Presence of amputations in the lower limbs; Presence of thrombosis; Deficit in cognitive ability defined by the Mini Mental State Examination (MEEM).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-3fvm6v	Effects of the association of the use of cholesterol-lowering medication and regular practice of physical exercise in people infected with HIV	Not yet recruiting	Intervention	2016-12-28	<NULL>	<NULL>	1123	Association betwwen statin and regular physical activity in people infected by HIV: randomized clinical trial, double-blind and placebo-controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-10	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3fvm6v	<NULL>	Being HIV-infected and using antiretroviral therapy for more than a year and being dyslipidemic. Be over 18 years and less than 60. Have health conditions for the practice of the proposed physical exercises. Be sedentary. Have trip availability three times a week to the training location.	Having diagnosis of opportunistic infections in the last two years. Having a diagnosis of liver disease and/or nephropathy and/or neuropathy. Have a history of orthopedic surgery. Have an body mass index&gt; 30 kg / m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-3p4npx	Reduction assessment of cold or flu symptoms with Fluviral® compared to Resfenol®, in  adult participants	Not yet recruiting	Intervention	2017-01-04	<NULL>	<NULL>	1133	Prospective, multicenter, parallel, single-blinded, randomized, non-inferiority clinical study to evaluate the reduction of cold or flu symptoms with Fluviral® compared to Resfenol®, in  adult participants	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2017-03-01	Hospital das Clínicas de Porto Alegre	Scentryphar	https://ensaiosclinicos.gov.br/rg/RBR-3p4npx	<NULL>	Adults; Both genders; Age between 18 and 60; Patients diagnosed with flu or cold with congestive and exudative symptoms such as corizas, muscle aches, fever, headache, nasal congestion and other symptoms present in Influenza like illness; Women of childbearing potential should be sexually inactive or be using one of the acceptable methods of contraception; Women without childbearing potential must be surgically sterile or already have over 2 years post-menopause.	History of hypersensitivity to the components of the study formulations; history of alcohol or drug abuse; bronchial asthma, severe kidney or liver disease, high blood pressure, heart disease, diabetes, thyroid dysfunction, glaucoma or prostatic hypertrophy; history of asthma maintenance therapy and/or asthma attacks in the last 5 years; clinical evidence of immunosuppression; use of monoamine oxidase inhibitor medicines (eg .: phenelzine, iproniazid, isocarboxazid, harmaline, nialamide, pargyline, selegiline, toloxatone, tranylcypromine, moclobemide); surgery or dental intervention with general or spinal anesthesia; be vaccinated against the flu less than 1 week prior to study enrollment; use of tricyclic antidepressants (amitriptyline, clomipramine, imipramine), barbiturates or oral anticoagulants; pregnant or nursing women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-6c26hx	Oral minoxidil and spironolactone versus topical minoxidil for female pattern hair loss	Not yet recruiting	Intervention	2017-01-09	<NULL>	<NULL>	1140	Oral minoxidil and spironolactone versus topical minoxidil for female pattern hair loss	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2017-01-01	Faculdade Medicina da Universidade Estadual Paulista - UNESP	Faculdade Medicina da Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6c26hx	<NULL>	Patients with female pattern hair loss; age between 20 and 55 years	Patients who had been treated for hair loss in the last 6 months, patients with hipertension, heart and kidney disease, patients with other causes of hair loss tha female pattern hair loss, patients in childbearing age who not using contraception;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-9b3qqd	Influence of gingival cord retractor in the success rate of restorations near to  gingiva using two different materials.	Not yet recruiting	Intervention	2017-01-10	<NULL>	<NULL>	1141	Influences of gingival cord retractor in retention rate of non-carious cervical lesions restorations with different adhesive systems.   Randomized clinical trials.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	Hospital Odontológico da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9b3qqd	<NULL>	Healthy volunteers; both genres; presence of at least four non carious cervical lesions of similar dimensions in the same arc and opposite quadrants; good oral hygiene.	Presence of cavities, cracks or enamel fractures; extensive  or unsatisfactory restorations; recent restorations involving the labial surface; dentures or orthodontics; presence of periodontal disease and,or parafunctional habits; systemic disease and, or severe psychological; constant use of analgesic and, or anti-inflammatory or allergic response to dental products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-377483	Assessment of pain after adjustment occlusal in root canal treatment	Not yet recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1152	Assessment of postoperative pain after adjustment occlusal in endodontic treatment: a randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-17	Universidade Federal do Amazonas (UFAM)	Universidade Federal do Amazonas (UFAM)	https://ensaiosclinicos.gov.br/rg/RBR-377483	<NULL>	Healthy patients of both sexes (male and female) aged between 18 and 60  who have root canal treatment indication in molars permanent, diagnosed with irreversible pulpitis; presence of occlusal contact prior to endodontic treatment; presence of natural or artificial opposing tooth in the occlusal contact in treated endodontically teeth; to have phone number to contact.	Pregnant women, patients aged less than 18 and greater than 60 years, patients taking some anti-inflammatory medication or antibiotic treatment at the time, immunocompromised, with hypersensitivity to nonsteroidal anti-inflammatory; previous diagnosis of bruxism or clenching; absence of natural or artificial tooth opposite to the tooth to be treated endodontically; complications endodontic type: calcifications, external or internal resorption, partial formation of the apical apex with dental drilling, with longitudinal or vertical fractures and severe periodontal disease; treatments in multiple sessions; patients without phone contact.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-4jx4fw	Isostretching in low back pain	Not yet recruiting	Intervention	2017-01-17	<NULL>	<NULL>	1158	Isostretching method effect in chronic low back pain treatment in women	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Paraná	Secretaria Municipal de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-4jx4fw	<NULL>	women with low back pain, no smoker and pain analogic visual scale more than 1	low back surgery, without low back pain diagnosis, low back pain ethiology unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-3phpxb	Electrical stimulation in the brain combined with video game for children with Down&apos;s Syndrome	Not yet recruiting	Intervention	2017-01-24	<NULL>	<NULL>	1167	Virtual Reality and Transcranial Stimulation  direct current for improvement of upper limb motor function in children with Down&apos;s Syndrome: Randomized and double blind controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Nove de Julho	Conselho Nascionla de Pesquisa (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-3phpxb	<NULL>	Diagnosis of Down&apos;s Syndrome; Ability to understand and collaborate to carry out the procedures involved in the study; Age between six and twelve years; Complaints of impaired motor coordination of upper limbs; Responsible for their participation in the study by signing the Informed Consent Form.	Have undergone surgical procedures in the last 12 months prior to the start of the training sessions; Have structured orthopedic deformities in the upper limbs or spine with surgical indications; Carriers of epilepsy; Have a metal implant in the brain or hearing aids; Associated neurological pathology; Pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-2hd6sm	Joy Moving: early intervention for children	Not yet recruiting	Intervention	2017-01-25	<NULL>	<NULL>	1168	Early physical activity: evaluation proposal, monitoring and early intervention program and aquatic therapy in children	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2hd6sm	<NULL>	Typical children will be included and / or developmental delay; age 0-6 years; both sexes; parental consent	children with health contraindications to practice exercises; injuries or health conditions that contraindicate exercises in water	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-287qk4	(Con) Living with carpal tunnel syndrome severe degree: patients´report	Not yet recruiting	Intervention	2017-01-06	<NULL>	<NULL>	1170	(Con) Living with carpal tunnel syndrome severe degree: everyday narratives	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-287qk4	<NULL>	People of both sexes, medical diagnosis of carpal tunnel syndrome; test electromyography to report to carpal tunnel syndrome severe degree; pain and symptoms present for at least six months and positivity for the Phalen and Tinel tests.	History of trauma or previous surgery in the dominant upper limb or spine; subluxation of acromioclavicular and glenohumeral joint; osteoarthritis of joint complex of the elbow, wrist and hand; tendinopathy in joint complex of elbow, wrist and hand; diagnosis of rheumatic, degenerative or neurological disease; physical therapy and/or occupational therapy or use of orthosis in the last three months before entering the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-4n67h3	Prevention of tuberculosis  in prisions.	Not yet recruiting	Intervention	2016-12-16	<NULL>	<NULL>	1179	Primary prophylaxis for prevention of TB in prison&apos;s populations.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-07-01	Ministério da Ciência, Tecnologia, Inovações e Comunicações	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4n67h3	<NULL>	Minimum stay estimated at 24 months under a closed regime; age between 18 and 45 years; without active tuberculosis or previous use of isoniazid; without consuming alcohol at least 3 months.	Positive serology for HIV, hepatitis B and C; latent tuberculosis; liver enzymes three times the upper limit; use of any medication that influence the metabolism of P450 enzyme; acute or chronic renal failure; epilepsy; indigenous.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-35kjvg	Effects of intensive nutritional counseling on nutritional status and quality of life of patients with head and neck cancer  undergoing radiation therapy	Not yet recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1210	Effects of intensive nutritional counseling on nutritional status and quality of life of patients with head and neck cancer  undergoing radiation therapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-18	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35kjvg	<NULL>	Patients with head and neck cancer (oral cavity, oropharynx, hypopharynx and larynx); both sexes; aged 18 years and over, submitted to radiotherapy as a first-choice treatment or as adjuvant treatment (post-surgical).	Patients using parenteral nutrition; without cognitive ability to understand the concepts of the questionnaires; in palliative radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-9kwjgx	Acupuncture in the care of nausea and vomiting after surgery	Not yet recruiting	Intervention	2017-04-17	<NULL>	<NULL>	1215	The use of acupuncture in the prevention of nausea and vomiting postoperative	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Departamento de Anestesiologia da Faculdade de Medicina da Universidade Estadual Paulista	Faculdade de Medicina da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9kwjgx	<NULL>	female patients , aged 18 to 65 years , physical status I and II according to the American Society of Anesthesiologists ( ASA ) , undergoing abdominal elective gynecological surgery ( hysterectomy) under total intravenous anesthesia.	patients under 18 years , ASA III or IV , unable to report or respond to protocol , fear of acupuncture needle , inability to use P6 ( Neiguam ) , patients using a different antiemetic protocol .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-3y8v57	Estriol use at the entrance and inside of vagina improving coital pain in women after menopause	Not yet recruiting	Intervention	2017-05-12	<NULL>	<NULL>	1241	Use of estriol at distal third of the vaginal wall improving coital pain in women after menopause: a randomized, blinded and controlled trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3y8v57	<NULL>	Women with a clinical diagnosis of menopause; FSH over 40 mIU/ml with a minimum age of 40 years old and and maximum age of 65 with sex including penetration of penis into vagina and complaining of pain during penetration, which appeared in peri or postmenopausal with active sexual partners and stable relationship.	Women will be excluded if previous use of steroids in genital area in the last month; thromboembolism history; renal insufficiency; cholestatic jaundice; degenerative vulvar pathology; breast, endometrial, vulvar and vaginal cancer history; prior radiotherapy to the genital region; smoking; acute urogenital infections (vulvovaginitis, urinary tract infection and genital herpes); genital prolapse grades II, III and IV by Baden Walker; systemic hormonal therapy in the last three months; in treatment of depression; suffering from diabetes, thyroid disorders or cognitive restrictions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-9y2nn2	Diabetes and exercise	Not yet recruiting	Intervention	2017-03-14	<NULL>	<NULL>	1253	Type 2 diabetes and exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Universidade Federal do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes - HUOL	https://ensaiosclinicos.gov.br/rg/RBR-9y2nn2	<NULL>	Age between 30 and 70 years; body mass index between 25.0 and 39.9 kg/m2; diagnosis of type 2 diabetes for a period equal or greater than 1 year; insufficiently active or sedentary	Clinically unstable Diabetes (change in medication within the last two months); insulin-dependent; history of stroke, neuropathy or advanced retinopathy; pregnant or suspected pregnancy; contraindication for magnetic resonance imaging, according to the list available at: http://www.mrisafety.com/; severe musculoskeletal problems that limit the practice of physical activity; health problems that may interfere with the study protocols or safety during exercise; classified as &quot;risk&quot; for cardiovascular diseases; not submitting medical authorization to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-5p28n4	Effect of Walking and Intensive Exercise on the Health of healthy individuals	Not yet recruiting	Intervention	2017-06-19	<NULL>	<NULL>	1259	Isolated and combined effects of a Physical Exercise Session and Active Behavior on Cardiometabolic Aspects in healthy individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5p28n4	<NULL>	Volunteers with body fat percentage above 25% and 35%, for men and women, respectively; Age between 18 and 35 years; Insufficiently physically active; non smokers.	Voluntary with arterial hypertension; diabetes; In use of medication that influences the cardiovascular system; With bone or muscle limitation for walking or running.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-3tgsqp	Mechanical vibration used in Vibratory Platform after cardiac surgery.	Not yet recruiting	Intervention	2017-06-26	<NULL>	<NULL>	1269	Use of Mechanical Vibration Generated in Oscillating/Vibratory Platform in the Post-Operative Heart Surgery.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-12	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3tgsqp	<NULL>	Patients undergoing cardiac surgery; Both genes; Age between 18 and 80.	"Patients who die in the perioperative period
Patients who develop pulmonary or neurological complications that impede the evaluations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9595ds	Educational Video targeted to parents on neonatal Pain relief for newborn Screening Test	Not yet recruiting	Intervention	2017-06-28	<NULL>	<NULL>	1271	Effectiveness of an Instructional Video targeted to parents on neonatal Pain management for newborn Screening Test: a non-randomized, pragmatic clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-05	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9595ds	<NULL>	Mothers hospitalized in a rooming-in unit; who are fluent in Brazilian Portuguese; with preserved cognitive ability; whose newborns are eligible for neonatal screening, and can be breastfed, positioned on skin-to-skin contact or receive sweet tasting  solution.	Non-compliance in the technique of performing the neonatal screening test (two or than one puncture of calcaneus); blood sample for the neonatal screening collected through peripheral venipuncture or without the mothers&apos; presence; mothers and/or newborns who need hospitalization in another care unit during the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-8kzvsk	Effectiveness of Ocular Physiotherapy versus Home Exercises in the Convergence Insufficiency	Not yet recruiting	Intervention	2017-07-05	<NULL>	<NULL>	1279	Effectiveness of Ophthalmic Physiotherapy versus Home Exercises in the Convergence Insufficiency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-03	Faculdade Assis Gurgacz - FAG	Faculdade Assis Gurgacz - FAG	https://ensaiosclinicos.gov.br/rg/RBR-8kzvsk	<NULL>	"Age above 18 years old;
Convergence insuffiency symptons superior 11 from CISS (Convergence Insufficiency Symptom Survey)."	"Neurological diseases;
Ocular diseases under treatment;
Cognitive and behavioral changes."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-6724wt	Influences of the Types of Play in the Performance of the Throwing of Children With Normal Development	Not yet recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1326	Influence of Playing Practice on Typical Children&apos;s Throwing Performance	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de São Paulo Campus Baixada Santista	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-6724wt	<NULL>	Children capable of carrying out the proposed test; With absence of intellectual compromises; Neuropsychomotor; musculoskeletal	Children with physical and / or intellectual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-37vvwk	Brazilian version of Pre-PAQ Questionnaire	Not yet recruiting	Observational	2017-08-25	<NULL>	<NULL>	1347	Brazilian version of Preschool-age Children&apos;s Physical Activity Questionnaire (Pre-PAQ)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de São Paulo Campus Baixada Santista	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-37vvwk	<NULL>	Professional in the field of physical education; Professional physiotherapy; Occupational therapy	Less than 2 years of training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-2ttf8m	Pilates and Dance classes for patients diagnosed with Breast Cancer under treatment in Chemotherapy, Radiotherapy or Hormone therapy: Project MoveMama	Not yet recruiting	Intervention	2017-09-13	<NULL>	<NULL>	1373	Pilates and Dance to Breast Cancer patients undergoing treatment: MoveMama Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Fundação Universidade do Estado de Santa Catarina - UDESC	Fundação Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-2ttf8m	<NULL>	Patients older than 18 years; Diagnosis of clinical stage I to III of breast cancer; Being in the period of adjuvant treatment with chemotherapy, radiotherapy or hormone therapy; And receive the release of the oncologist responsible for the practice of physical activity, as well as the Physical Therapy Sector of CEPON.	Patients that present some orthopedic or neurological limitation that prevents the practice of physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-7cwtgg	Quality of postoperative recovery in women undergoing gallbladder surgeries	Not yet recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1390	Postoperative quality of recovery in women undergoing cholecystectomies: a randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-02	Faculdade de Medicina de Jundiaí	Hospital Regional de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-7cwtgg	<NULL>	Women; age between 18 and 65 years; ASA I or II physical condition; to undergo laparoscopic cholecystectomy performed electively and indicated due to cholelithiasis.	Patients who refuse to participate in the research; who are taking any sedative, opioid or sleep inducing drugs; Patients who refuse to participate in the research; who are taking any sedative, opioid or sleep inducing drugs; who have a history of allergy to any drug to be used in the study; carriers of severe obesity; pregnant or breastfeeding; carriers of pathologies that cause some cognitive deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-3gz8hc	A Clinical Trial of Spectrila® in Adult Subjects with Newly Diagnosed Acute Lymphoblastic Leukaemia	Not yet recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1392	"A Clinical Phase II Trial to Describe Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of Spectrila® with the
Pharmaceutical Active Ingredient Recombinant L-Asparaginase in Adult Subjects with Newly Diagnosed Acute B-Cell Lymphoblastic Leukaemia"	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-12-15	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3gz8hc	<NULL>	Subjects with newly diagnosed pathologically confirmed acute B-cell lymphoblastic leukaemia; Female or male higher or equal to 18 years of age; Eligible for treatment and treated according to the underlying treatment protocol BRALL 2014; Written informed consent given freely; Subject expresses his/her understanding of the trial procedures and willingness to abide by them during the course of the trial; Female subjects of child-bearing potential must use a highly effective method of contraception (pearl index less than 1%)  in combination with a second method of contraception during the trial and for at least 3 months after Spectrila discontinuation; Men should use effective contraceptive measures and be advised to not father a child while receiving ASNase.	"Pre-treatment with any ASNase preparation; 
Hypersensitivity to the active substance, Escherichia coli-ASNase preparation or to any of the excipients; Pancreatitis at the time of treatment initiation or history of pancreatitis; Pre-existing known coagulopathy; Severe liver function impairment; History of serious haemorrhage or serious thrombosis; Other current malignancies; Uncontrolled active infection; Evidence of infection with the human immunodeficiency virus, hepatitis B or C, human T-lymphotropic virus type I and
II, syphilis or Chagas disease (American trypanosomiasis); Pregnancy as verified by a positive pregnancy test or nursing woman; Active psychiatric or mental illness making informed consent or careful clinical follow-up unlikely; Evidence or suspicion that the subject might not comply with the requirements of the trial protocol; Evidence or suspicion that the subject is unwilling or unable to
understand the information given to him/her within the informed consent procedure; Any other factor which in the investigator’s opinion is likely to compromise the subject’s ability to participate in the trial; The subject is an employee or direct relative of an employee of the contract research organisation (CRO) involved in the trial,
the trial site or medac; The subject is imprisoned or is lawfully kept in an institution; The subject has participated within 3 months before screening or plans to participate in a clinical trial (except the underlying treatment protocol BRALL 2014); Previous participation in this clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-2rt2wy	Effect of Ginger on controlling blood sugar and fat levels in people with Type 2 Diabetes Mellitus	Not yet recruiting	Intervention	2017-10-11	<NULL>	<NULL>	1418	Effect of Ginger (Zingiber Officinale) on glycemic and lipemic control of people with Type 2 Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-23	Universidade Estadual do Piauí	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2rt2wy	<NULL>	Volunteers with type 2 diabetes for at least 2 years;both sexes;age between 20 and 80 years;be enrolled and monitored in the E-SUS AB system;treatment with oral antidiabetics;have glycated hemoglobin between 7 and 10%.	Smoking volunteers;history of alcohol abuse; gestation and lactation;consumption of ginger in the usual diet;cognitive alterations;diagnosis of diabetes pathologies or complications such as heart, renal, gastrointestinal and hepatic heart diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-9h77k7	Effects of Ear Acupuncture and Cupping Therapy with glasses on Back Pain	Not yet recruiting	Intervention	2017-10-16	<NULL>	<NULL>	1420	Effects of Auricular Acupuncture and Cupping Therapy on Chronic Back Pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9h77k7	<NULL>	Age (between 18 and 80 years); orientation in time, space and person; presence of chronic pain in the vertebral column for three months or more, of any origin; self-report of pain intensity bigger or equal 4, and availability of time for submission to treatment sessions.	Infection, inflammation or injury in the ear; use of piercing (except normal earring); allergy to metal or micropore; decreased skin turgor, skin lesions or diseases in the dorsal region; treatments with anticoagulant; use of other energy therapies (massage, herbal medicine, reiki, floral therapy) up to three months prior to the study; physiotherapy treatment concomitant with the proposed interventions; continuous use of medication for pain relief; neurological, psychiatric or rheumatic disease; pregnancy; breastfeeding; and not respond to three attempts of contact made by the researcher.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-7k6pfb	Effects of high intensity of exercise  in female athletes	Not yet recruiting	Intervention	2016-03-02	<NULL>	<NULL>	1421	"The peripheral muscular  oxygenation and ventilatory during dynamic exercise of high
intensity players from football: A randomized clinical trial of the effects of
respiratory muscle training in improving exercise tolerance"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-18	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7k6pfb	<NULL>	Twenty healthy volunteers; female; non-smoking; aged between 18 and 25 years; athletes	Cardiac diagnosis; renal; hepatic; pulmonary; neurological; psychiatric; hematological or metabolic disorders; that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-43mg87	Effect of Sublingual Supplementation with Resveratrol in patients with Renal Disease	Not yet recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1422	Effect of Supplementation of Resveratrol Sublingual on Oxidative And Inflammatory Stress Markers in Hemodialysis Patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-43mg87	<NULL>	Patients of both sexes; over the age of 19; diagnosis of chronic kidney disease and who have been on a regular hemodialysis program for at least 3 months, since this is the time used to confirm the chronicity of renal disease	Patients with a history of hypersensitivity to resveratrol will be excluded from the study; patients with food allergy containing resveratrol;cancer patients; with acute renal failure; in use of anti-inflammatory drugs; use of omega 3 supplementation; bedridden patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-22fy6t	Clinical Trial of Lurbinectedin / Doxorubicin versus Cyclophosphamide, Doxorubicin and Vincristine or Topotecan as Treatment in Patients with Lung Cancer.	Not yet recruiting	Intervention	2017-10-23	<NULL>	<NULL>	1438	Phase III Randomized Clinical Trial of Lurbinectedin (PM01183)/ Doxorubicin (DOX) versus Cyclophosphamide (CTX), Doxorubicin (DOX) and Vincristine (VCR) (CAV) or Topotecan as Treatment in Patients with Small-Cell Lung Cancer (SCLC) Who Failed One Prior Platinum-containing Line (ATLANTIS Trial)	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-02-01	Hospital de Caridade de Ijui	INC Research	https://ensaiosclinicos.gov.br/rg/RBR-22fy6t	<NULL>	"Voluntary written informed consent of the patient; Adult patients aged more than 18 years; Diagnosis of limited or extensive stage small cells lung cancer (SCLC);  Small-cell carcinoma of unknown primary site with or without neuroendocrine; ECOG PS lower than 2; Adequate hematological, renal, metabolic and hepatic function in an assessment performed within 7 days (+ 3 day window) of randomization;	At least three weeks since last prior anticancer treatment and recovery to grade less than 1 from any AE related to previous anticancer treatment;	Prior Radiotheraphy (RT): At least four weeks since completion of whole-brain RT (WBRT), at least two weeks since completion of PCI, and to any other site not previously specified; Evidence of non-childbearing status for women of childbearing potential (WOCBP). WOCBP must agree to use a highly effective contraceptive measure up to six weeks after treatment discontinuation."	"More than one prior chemotherapy-containing regimen (including patients re-challenged with same initial regimen); 
Patients who never received any platinum-containing regimen for SCLC treatment; 
Prior treatment with PM01183, topotecan or anthracyclines;
Limited-stage patients who are candidates for local or regional therapy, including PCI, thoracic RT or both, must have been offered that option and completed treatment or refused it prior to randomization;
Impending need for palliative RT or surgery for pathological fractures and/or for medullary compression within four weeks prior to randomization;
Symptomatic, or steroid-requiring, or progressing CNS disease involvement during at least four weeks prior to randomization; 	Concomitant diseases/conditions:
History (within one year prior to randomization) or presence of unstable angina, myocardial infarction, congestive heart failure or clinically significant valvular heart disease;
Symptomatic or uncontrolled arrhythmia despite ongoing treatment;
Patients with any immunodeficiency, including those known to be or have been infected by human immunodeficiency virus (HIV);
Ongoing, treatment-requiring, non-neoplastic chronic liver disease of any origin,	Active infection or increased risk due to external drainages, Intermittent or continuous oxygen requirement within two weeks prior to randomization. Patients with confirmed or suspected diagnosis of diffuse interstitial lung disease (ILD) or pulmonary fibrosis, Patients with a second invasive malignancy treated with chemotherapy and/or RT. Patients with a previous malignancy that was completely resected with curative intention three or more years prior to randomization, and who has been continuously in remission since then will be permitted, Limitation of the patient’s ability to comply with the treatment or to follow the protocol, Documented or suspected invasive fungal infections requiring systemic treatment within 12 weeks of randomization; Pregnant or breast feeding women."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-3n2f38	Effect of using a Mobile Application for foot Care of people with Diabetes	Not yet recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1442	Multimedia Application on Mobile Platform to Promote foot Care for people with Diabetes: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Estadual do Ceará - UECE	Universidade Estadual do Ceará - UECE	https://ensaiosclinicos.gov.br/rg/RBR-3n2f38	<NULL>	Be 18 years of age or over; having a medical diagnosis of type 2 diabetes mellitus; be accompanied by the Integrated Diabetes and Hypertension Center; possession of a mobile device for personal use android smartphone; ability and familiarity with application usage.	Persons with apparent diseases and conditions with marked functional dependence; cognitive deficit or any difficulty that impedes the handling of the device and responses to the instrument; and present pre-existing diabetic ulcer. Discontinuity criteria: non-attendance at the study stages; illness or death during the course of the study; giving up and not answering calls. Three attempts of interleaved contacts will be made.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-3vfqfb	Protocol of nursing in the Prehospital Care in the Emergencies and Cardiovascular Emergencies	Not yet recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1443	Therapeutic Nursing Guidelines for Prehospital Clinical Care in Emergencies and Cardiovascular Emergencies	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-10	Faculdade de Enfermagem e Medicina Nova Esperança	Hospital Regional Tarcísio de Vasconcelos Maia	https://ensaiosclinicos.gov.br/rg/RBR-3vfqfb	<NULL>	Patients users of the Unified Health System; of both sexes; 18 years of age or older; diagnosed with cardiovascular disease in an emergency and emergency situation.	Will be excluded from the sample: communication barriers; with degenerative neurological diseases; patients who present a surgical plan that influences the follow-up; pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-9cr4b2	Strengthening Training and Blood Flow Restriction to increase hand&apos;s strength	Not yet recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1462	Comparison of different Strengthening protocols associated with Blood Flow Restriction to increase handgrip strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-30	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9cr4b2	<NULL>	"Both sexes; with age between 18 and 35 years old; students from Universidade Federal de Santa Catarina - UFSC, Campus Araranguá. 
There will be selected only the participants that are apt to perform the proposed tasks."	Subjects with a forearm injury that may interfere with the muscle integrity; subjects with recent fractures in wrist and finger regions; subjects with upper limb pain for any reason. Participants with obesity, hypertension, cardiopathy; individuals with cognitive deficits; workes with manual tasks; participants that perform regular physical activity; and participants using medications that may interfere with final results of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-6fp5qt	The effect of Motivational Interview on the self-care of patients with Heart Failure	Not yet recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1482	"The effect of Motivational Interview on the self-care of patients with Heart Failure:
randomized clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Programa de Pós Graduação em Ciências Cardiovasculares da Universidade Federal Fluminense	Universidad de La Republica	https://ensaiosclinicos.gov.br/rg/RBR-6fp5qt	<NULL>	Patients with a medical diagnosis of HF regardless of etiology; normal or decreased ejection fraction; older than 18 years; with functional classes I-III NYHA; be participating in the clinics in the specialized clinics included in this research.	Patients with cognitive neurological sequelae self-reported or identified during the multidisciplinary consultation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-2z3ps4	Effects of recreational football on bone, body fat, strength, agility, walking speed, short-term memory and the ability to think fast in the elderly	Not yet recruiting	Intervention	2017-11-17	<NULL>	<NULL>	1484	Effects of recreational football on body composition, physical abilities and executive functions in elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	universidade federal de pernambuco	universidade federal de pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2z3ps4	<NULL>	"Individuals male and female;
Age between 60 and 79 years;
Carriers of controlled hypertension;
Individuals classified as sedentary;
To present a higher score than the criteria established in the test Mini Mental State Examination"	"Absolute contraindication for performing physical exercises.
Living outside the metropolitan area of Recife.
Have some physical amputation that limits exercise"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-89rt6v	Warming Program to Prevent Injuries in Basketball Athletes	Not yet recruiting	Intervention	2017-11-27	<NULL>	<NULL>	1503	Warming Program to Prevent Injuries in Basketball Athletes:Cluster Randomised Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-30	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89rt6v	<NULL>	As inclusion criterion were established; healthy volunteers; both genders; that carried out at least 4 trainings per week; in addition to 15 to 30 matches per season.	As an exclusion criterion; athletes with some musculoskeletal injury were established prior to the beginning of the study; which prevented the performance of the injury prevention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-9zpc27	Study of the cardiac safety of Ibogaine accompanied by psychotherapy in the treatment of addiction to cocaine and crack.	Not yet recruiting	Intervention	2017-12-11	<NULL>	<NULL>	1513	Cocaine and crack Addiction Treatment with Ibogaine	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2018-01-02	Instituto Veracruz de Pesquisa e Tratamento da Dependência Química Ltda.	Prefeitura Municipal de Araguari Prefeitura de Araguari	https://ensaiosclinicos.gov.br/rg/RBR-9zpc27	<NULL>	Age between 18 and 50 years; complete primary education; absence of abnormalities in the evaluation of hemogram, transaminases, gamma-GT, glycemia, hepatitis C, HIV serology, Beta HCG for women, sodium, potassium, magnesium and electrocardiogram with a report attesting the absence of any abnormalities, including prolongation of the QT interval ; cocaine and / or crack dependence, with at least one unsuccessful attempt at treatment; perspective of return to family life; maintenance of abstinence from psychoactive drugs for 30 days between the initial evaluation and the medication session (ascertained by personal reporting and urinalysis of urine at all psychological visits and the day the drug is received); interruption of the use of antidepressants and mood stabilizers, under the guidance of the clinician responsible	Psychotic disorder; schizophrenia and any other psychiatric disorder in which you are in crisis; exams beyond normality; prolonged QT interval demonstrated on the electrocardiogram; pregnancy and breastfeeding; large surgeries in the last 6 months; uncontrolled arterial hypertension; uncontrolled diabetes; myocardial infarction and ventricular arrhythmias; hepatic insufficiency; previous history of accidents with head trauma and loss of consciousness; Alzheimer&apos;s disease; Parkinson&apos;s disease; Being a carrier of epilepsy; motor difficulties that may interfere with writing ability; do not be abstinent from psychoactive drugs for 30 days on the day you receive the drug treatment; be under the influence of antidepressants and mood stabilizing medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-3t7fcy	A clinical study to evaluate the safety and blood concentration of melatonin nasal suspension in healthy male research participants.	Not yet recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1517	A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of melatonin nasal suspension, after a single dose in healthy male participants.	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-12-21	Cosmed Indústria de Cosméticos e Medicamentos S.A.	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-3t7fcy	<NULL>	Healthy research participants; male gender; age equal to 18 and less than or equal to 35 years; body weight greater than or equal to 50 kg and BMI less than or equal to 30 kg / m2.	Research participants with complementary examinations outside normal values; history of excessive alcohol consumption; history of psychotropic drug use; be non-tolerant to the nasal spray test; history of upper or lower respiratory tract infection (1 month prior to study participation).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-25dm9p	Benefits of light and shock in the head more walking on a treadmill walking in improving stroke sequelae.	Not yet recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1518	Effects of the combination of photobiomodulation, transcranial direct current stimulation and treadmill training on functional mobility in stroke survivors: Protocol for a randomized, sham-controlled, double-blind clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-25dm9p	<NULL>	diagnosis of stroke six months to five years prior to study; Hemiparesis secondary to single unilateral event; Independent gait; Age 45 to 60 years; performance of the functional tests and Physical Fitness; incremental cardiopulmonary exercise test; consent to their participation in the study by signing the Informed Consent Form	Joint pain in lower limbs that impairs function;Obesity of sufficient severity to limit gait training; Cardiovascular condition or cognitive impairment that renders the tests impossible; History of seizures; History of head trauma; Previous head surgery; metal implants on the head.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-84gg5w	Effects of Pilates Method Breaths on Balance, leg Tiredness, and Routine Activities of Fallers Elderly	Not yet recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1522	Effects of Pilates Method Breaths on balance, lower limb fatigue and functional capacity of fallers elderly: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-20	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-84gg5w	<NULL>	Age greater than or equal to 65 years; Good cognitive status, score greater or equal 17 in the mini-questionnaire questionnaire of mental state; History of falls in the last 12 months; Fear of falling measured by the FES-I-Brazil questionnaire.	Arthroplasty, arthrodesis, or knee, ankle and or hip osteotomy; Those who refuse to participate in data collection; Inability to perform the proposed monopodal balance test and or protocol of intervention; Less than 80% of frequency in sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8dp876	Effects of Omega 3 and Cardo Mariano on MiRNAs related to non-alcoholic fatty liver disease.	Not yet recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1527	Epigenetic modulation by N-3 Polyunsaturated Fatty Acids and bioactive compounds (Silybum Marianum L) in Non-Alcoholic Fatty Liver Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-10	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8dp876	<NULL>	Be 19 years of age or older; diagnosis of NAFLD by abdominal ultrasonography, and liver biopsy in the last 24 months preceding the intervention	Viral hepatitis; infectious fever or outbreaks; cancer with or without chemotherapy and radiotherapy; inflammatory diseases of the gastrointestinal tract; transplant, trauma, surgery or hospitalization in the last 30 days; use of steroids or non-steroidal anti-inflammatories or immunomodulatory agents or antibiotics; use of n-3 fatty acid supplement in the last 3 months prior to study; pregnancy and lactation; alcohol intake greater than 20g / day for women and 30g / day for men	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-6y979g	Laser therapy in Patients with Rapids Maxillary Expansion needs	Not yet recruiting	Intervention	2017-12-19	<NULL>	<NULL>	1531	Low-level Laser therapy in Rapid Maxillary Expansion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-20	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6y979g	<NULL>	Patients in the mixed dentition phase; maxillary atresia	Patients with previous orthodontic treatment history; that require other modalities of interceptive orthodontic treatment within the experimental period (10 months); systemic diseases that interfere with bone metabolism, or use medications that alter bone metabolism; craniofacial malformations; suspected or diagnosed oral cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-4hz5vn	Impact of Pelvic Exercise guidance on Urinary loss and pelvic Organ Falls	Not yet recruiting	Intervention	2017-12-21	<NULL>	<NULL>	1537	Impact of guidance of Pelvic Exercises on urinary Incontinence and genital Prolapse	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4hz5vn	<NULL>	Women with urinary incontinence with predominance of stress urinary incontinence; Women who voluntarily accept and sign the Informed Consent Form (TCLE); Women who have a cell phone; Know how to read and write.	Neurological problems that compromise the understanding for the practice of exercises, or suggestive of neurogenic bladder; Diabetes Mellitus; Total absence of muscle contraction of the pelvic floor (P = 0); pelvic floor hypertonicity; Anterior surgery of the pelvic floor; Prolapse of pelvic organs greater than stage II; Use of local hormone; Proven or suspected pregnancy; Prior treatment for urinary incontinence; Three or more lower urinary tract infections in the last 12 months; Ultrasound image with poor resolution for analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-6kyh2g	Treatment of Temporomandibular Dysfunction with the use of fatigue-resistance Exercises	Not yet recruiting	Intervention	2018-01-03	<NULL>	<NULL>	1543	"Isometric Exercises of Muscular Resistance to Fatigue in the treatment of Dysfunction
Temporomandibular via Biofeedback: randomized control study"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6kyh2g	<NULL>	Volunteers who have temporomandibular pain lasting more than 06 months; Who have a permanent dentition with at least 28 permanent teeth; Without periodontitis.	Volunteers who already suffer craniofacial trauma; Rheumatic diseases; Volunteers who use analgesics; Anti-inflammatory; Neurological or cognitive deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-3knbwp	Effects of a therapeutic exercise program associated or not with electrical currents in patients with chronic neck pain	Not yet recruiting	Intervention	2018-01-17	<NULL>	<NULL>	1573	Effects of a program of therapeutic exercises associated or not to electrotherapy in patients with chronic neck pain: blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3knbwp	<NULL>	Individuals of both genders; aged between 18 and 45 years; and with chronic cervicalgia (for more than 90 days).	Individuals who presented a history of cervical trauma; head, face or cervical surgery; cervical hernia; degenerative diseases of the spine; pain radiated to the upper limbs; have undergone physiotherapeutic treatment for the cervical region in the last three months; use of analgesic, anti-inflammatory or muscle relaxants in the last week; presence of systemic diseases; medical diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9tvdnz	The effect of Aerobic Training on biological factors after Stroke	Not yet recruiting	Intervention	2018-01-18	<NULL>	<NULL>	1581	Efficacy of Aerobic Training in changing inflammatory mediators and neurotrophins and the impact on clinical outcomes in individuals with chronic vascular Stroke: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Fundação de Amparo à Pesquisa do Estado de Minas Gerai	https://ensaiosclinicos.gov.br/rg/RBR-9tvdnz	<NULL>	Subjects will be eligible if they have a clinical diagnosis of first or recurrent chronic stroke (&gt;6 months); are &gt; 18 years of age; are inactive or insufficiently active based on the standards of the Centers for Disease Control and Prevention adjusted activity scores on Human Activity Profile (HAP) under 74 (inactive or moderately active) and have medical permission.	Exclusion criteria will be cognitive impairments; as determined by the Mini-Mental State Exam cut-off scores; language impairments (comprehensive aphasia) and pain and/ or other adverse health conditions that might affect their performance in the intervention. Patients who use drugs or who have inflammatory or autoimmune diseases that may interfere with the concentrations of inflammatory mediators or neurotrophins will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-63czrx	Effect of supplementation of nondigestible fibers and bacteria of beneficial effect to the body on blood tests, symptoms of depression and diabetes in patients with type 1 and 2 diabetes.	Not yet recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1585	Effect of prebiotic and simbiotic supplementation on lipidic and glycemic profile, inflammatory markers and symptoms of depression and anxiety in individuals with diabetes mellitus type 1 and 2: randomized clinical trial, placebo-controlled and triple blind	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-11-15	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-63czrx	<NULL>	Volunteers who are diagnosed with type 1 or type 2 diabetes mellitus; both genders; age above 19 years.	Individuals with previous gastrointestinal diseases; previous gastrointestinal surgeries; intolerances or food allergies; use of anti-inflammatory drugs or antibiotics up to three months prior to study or during study; regular use of laxatives; use of opioid narcotic analgesics; use of appetite suppressants; current or previous use up to one month of probiotic symbiotic prebiotics or products enriched with these ingredients; presenting intolerance to prebiotics or probiotics or symbiotics; pregnant or lactating women; following a diet for weight loss or gain in the last three months; current follow-up of unusual diets; alcohol dependence; illicit drugs and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-2yprts	Effectiveness of tele-rehabilitation compared to traditional physiotherapy in the treatment of stroke	Not yet recruiting	Intervention	2018-01-23	<NULL>	<NULL>	1589	Effectiveness of telereabilitation in the functional improvement, adherence and oxidative profile of people who had Stroke compared to usual care physical therapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal do Ceara	Universidade Federal de Goias	https://ensaiosclinicos.gov.br/rg/RBR-2yprts	<NULL>	volunteer with age of 18 years or more; presence of caregiver; and recent stroke defined as a diagnosis of stroke within four weeks.	Cognitive deficits established by the minimum score of 20, through the Montreal Cognitive Assessment (MoCA); cognitive assessment tool;  users who did not sign the Informed Consent Form (TCLE); excessive spasticity in the affected upper extremity defined by the score&gt; 3 by the Modified Ashworth Spasticity Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-3byz2c	Evaluation of inflammatory substances in the blood of patients with recurrent glioblastoma in treatment with inhalation of perillyl alcohol associated with reduced carbohydrate diet and supplementation with omega 3	Not yet recruiting	Intervention	2018-01-24	<NULL>	<NULL>	1591	Evatuation of the metabolomic profile of patients with recurrent glioblastoma in treatment with perillyl alcohol intranasal administration associated with the ketogenic diet and dha suplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-26	Hospital Universitário Antônio Pedro	Instituto de Química da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3byz2c	<NULL>	Adults with glioblastoma; submitted to surgical procedure with the partial withdrawal of the tumor; who presented recurrences and are under chemotherapeutic treatment.	Participants who initiate immunotherapeutic treatment; or develop autoimmune; hepatic or renal disease; or discontinue the ketogenic diet; perillyl alcohol inhalation or supplement will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-7js6r9	Effect of exercise on adolescent health risk factors	Not yet recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1608	Combined Physical Exercise and Cardiometabolic Risk Factors in Adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Estadual do Norte do Paraná	Universidade Estadual do Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7js6r9	<NULL>	Be between 15 and 19 years old; not have recognized cardiovascular disease; no diagnosis of diabetes and hypertension; not been participating in a physical activity / exercise program for at least three months; do not present limiting conditions for the practice of physical exercises	Report stage of sexual maturation below IV, present body mass index greater than 40; do not meet pre-participation recommendations on physical tests and weekly sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-8b9npb	PK/PD Study of InsuBiomm N (NPH Insulin) in Comparison to Humulin N in Type 1 patients (T1DM)	Not yet recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1613	Cross-over, double-blind, randomized, single dose euglycemic hyperinsulinemic clamp study to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of NPH recombinant human insulin produced by Biomm/Bioton and the reference product Humulin® N produced by Eli Lilly in type 1 diabetic patients (T1DM).	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-07-15	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-8b9npb	<NULL>	"Be between 18 and 65 years old, inclusive;Have been diagnosed with type 1 diabetes for at least 1 year;Body Mass Index (BMI) between 18 and 30 kg / m2;Being on insulin therapy;Have basic knowledge of the disease that allows self-adjustment of the insulin doseaccording to the algorithm described in the protocol;Have positive antiGAD antibody or antiIA2 antibody positive or C-peptide levels less than 0.5ng / mL (0.2 mmol / L)
• Participants should be free of any detectable micro- and macroangiopathic complications that are clinically significant at the discretion of the investigator and any major disease other than diabetes as indicated by medical history, physical examination, electrocardiogram, or routine laboratory exams."	Type 2 diabetes;Use of any oral hypoglycemic; Any factor that opposes the inclusion criteria;Pregnant or lactating women who are breastfeeding;Participants in the use of glucocorticoids or any other medication that may interfere with glycemic control, at the discretion of the investigator;Any concomitant medical condition that may interfere with the performance of the protocol, including but not limited to CLAMP	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-9r8drp	Clinical study to evaluate the blood levels of CA-125 and CD-23 substances and the amount of nerve fibers in the endometrium in patients with pain associated with Endometriosis: before and after 6 months of use of the Levonorgestrel-Releasing Intrauterine System (progesterone hormone IUD) or the Etonogestrel Subdermal Implant (Progesterone Hormone Implant)	Not yet recruiting	Intervention	2018-02-05	<NULL>	<NULL>	1626	A randomized clinical trial evaluating of CA-125 and CD 23 soluble  serum levels and nerve fibers in the endometrium of patients with pain associated with Endometriosis before and after 6 months of use of the Levonorgestrel-releasing Intrauterine System or the Etonogestrel Subdermal Implant	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-02-01	faculdade de ciencias medicas da universidade estadual de campinas	faculdade de ciencias medicas da universidade estadual de campinas	https://ensaiosclinicos.gov.br/rg/RBR-9r8drp	<NULL>	Women between age 18 to 45 years old, who entered at the study at the time of randomization and did not discontinue follow-up until the last visit in the previous study, 180 days after device insertion, these women already have a diagnosis and surgical staging or endometriosis imaging method (according to ASRM, 1997) and have reported chronic pelvic pain and / or dysmenorrhea with pain scores greater than or equal to 4 on the visual analog pain scale in the moment of randomization; agree to participate in the study and sign the informed consent term	Pregnancy; current proposoal to get pregnant; desire to only use the LNG-IUS as treatment and control of pain due to endometriosis; personal history of uterine Mullerian malformation or acquired uterine abnormalities, such as synechiae, or surgical absence of uterus; contraindications to the use of the LNG-SIU: current or recurrent pelvic inflammatory disease; acute infection of lower genital tract; present purulent cervicitis; history of miscarriage in the last three months; history of puerperal infection in the last three months; malignant uterine, cervical, hormone-dependent tumors; genital uterine bleeding with uncertain or undiagnosed etiology; conditions associated with increased susceptibility to infections; acute liver disease or malignant liver tumors; acute thromboembolism; hypersensitivity to levonorgestrel; contraindications to the use of the ENG implant: acute thromboembolism; malignant uterine tumors, hormones-dependent; genital uterine bleeding with uncertain or undiagnosed etiology; acute liver disease or malignant liver tumors; hypersensitivity to etonorgestrel or to any component of the implant; abuse of illicit drugs or alcohol; morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-6wnzhq	Study of Talipes Cavus after the application of Electrotherapy	Not yet recruiting	Intervention	2018-02-05	<NULL>	<NULL>	1631	Baropodométrico study in Talipes Cavus Essentials after the passage of Symmetrical Biphasic Currents	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-15	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-6wnzhq	<NULL>	Subjects between 18 and 45 years; both genres; with the pes cavus, diagnosed with a lateral radiograph in charge with the dominant foot where the angle of the internal Bartani was determined, which should be 125º.	Having a osteoarticular, tumoral or systemic degenerative diseases; having undergone foot surgery; having received manual foot treatment of some sort in the four weeks prior to the study; Using orthopodiatric treatment for pes cavus; having had serious trauma to the foot.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-7mvgfc	"Pharmacokinetics (PK) and pharmacodynamics  (PD) 
 study of InsuBiomm R (Regular Insulin) in comparison to Humulin R in Type 1 patients"	Not yet recruiting	Intervention	2018-02-06	<NULL>	<NULL>	1632	A double-blind, randomized, clinical study with a single subcutaneous dose to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of two Regular recombinant human insulins, the test drug being the Regular Human Insulin produced by Bioton SA and the reference medicine Humulin® R produced by Eli Lilly Brasil Ltda using euglycemic and hyperinsulinemic clamp technique in type 1 diabetic research participants (PPES005/17)	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-07-15	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	Instituto de Ciências Farmacêuticas de Estudos e Pesquisas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-7mvgfc	<NULL>	Be between 18 and 65 years old, inclusive;have been diagnosed with type 1 diabetes for at least 1 year;body Mass Index (BMI) between 18 and 30 kg / m2;being on insulin therapy;have basic knowledge of the disease that allows self-adjustment of the insulin dose according to the algorithm described in the protocol;h have positive anti-GAD antibody or anti-IA2 antibody positive or C-peptide levels less than 0.5ng / mL (0.2 mmol / L);participants should be free of any detectable micro- and macroangiopathic complications that are clinically significant at the discretion of the investigator and any major disease other than diabetes as indicated by medical history, physical examination, electrocardiogram, or routine laboratory exams	Type 2 diabetes;use of any oral hypoglycemic;any factor that opposes the inclusion criteria; pregnant or lactating women who are breastfeeding; participants in the use of glucocorticoids or any other medication that may interfere with glycemic control, at the discretion of the investigator; any concomitant medical condition that may interfere with the performance of the protocol, including but not limited to clamp; participant with chronic hepatopathy, chronic renal failure, renal insufficiency, congestive heart failure grade II or above; history of cancer in the last 5 years;participant with indication for any surgical procedure in the next 6 months;h history of major surgery in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-4vz9c4	Efficacy and Safety Study with 24-month Follow-up of Oleogel-S10 in Patients a group of inherited disorders that involve the formation of blisters following trivial trauma	Not yet recruiting	Intervention	2018-02-16	<NULL>	<NULL>	1642	"Double-blind, Randomised, Vehicle-controlled, Phase III, Efficacy
and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in Patients with Inherited Epidermolysis Bullosa"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-03-01	Hospital da Criança Santo Antônio - Irmandade Santa Casa de Misericórdia de Porto Alegre	Inc Research Br Serviços de Pesquisa Clínica LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4vz9c4	<NULL>	"Male and female patients with any subtype of inherited Epidermolyse bullosa age more than 4 years; Patients with an Epidermolyse bullosa target wound; Patient and/or his/her legal representative has/have been informed, has/have read and
understood the patient information/informed consent form, and has/have given written
informed consent; Patient and/or his/her legal representative must be able and willing to follow study
procedures and instructions."	"Epidermolyse bullosa target wound with clinical signs of local infection; Use of systemic antibiotics for wound-related infections within seven days prior to enrolment; Administration of systemic or topical steroids within 30 days before enrolment; Immunosuppressive therapy or cytotoxic chemotherapy within 60 days prior to enrolment; Patient has undergone stem cell transplant or gene therapy for the treatment of inherited EB; Current and/or former malignancy; Enrolment in any interventional study or treated with any investigational drug for any
disease within 4 weeks prior to study entry; Factors present in the patient and/or his/her legal representative that could interfere with study compliance such as inability to attend scheduled study visits or compliance with
home dressing changes; Pregnant or nursing women and women of childbearing potential including postmenarchal female adolescents not willing to use an effective form of birth control
(e.g., implant, injectable, combined oral contraceptive, intrauterine contraceptive device, sexual abstinence, vasectomised partner) during participation in the study (and at least 3 months thereafter); Patient is a member of the investigational team or his/her immediate family; Patient lives in the same household as a study participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-46kbnp	Cupping in patients with neck pain.	Not yet recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1657	Effects of cupping therapy on myofascial trigger points in the upper trapezius muscle of patients with chronic neck pain.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-30	Departamento de Ciências da Saúde e Biológicas da Universidade Federal do Amapá	Departamento de Ciências da Saúde e Biológicas da Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-46kbnp	<NULL>	"Neck Disability Index (NDI) score&gt;5 points and punctuation on the Numeric Rating Scale (NRS) &gt; 3;
Present bilateral and active trigger point, centrally located in the trapezius muscle descendent fibers."	The exclusion criteria adopted in the present study will be individuals with a history of cervical trauma; head, face or cervical surgery; cervical hernia; degenerative diseases of the spine; have undergone physiotherapeutic treatment in the last three months; use of analgesic, anti-inflammatory or muscle relaxants in the last week; presence of systemic diseases; medical diagnosis of fibromyalgia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-2s58pz	Supplementation of serum whey proteins in elderly diabetic type 2 subjects submitted to a program of bodybuilding exercises as a strategy for muscle preservation and blood glucose control: controlled clinical research	Not yet recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1660	Supplementation of whey protein in type 2 diabetic elderly subjects submitted to a resisted exercise program as strategy to preserve lean mass and blood glucose control: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2s58pz	<NULL>	"Volunteers aged 65-89 years; both sexes; good physical and mental condition; creatinine tests less than 3 months within the reference values;
To present DM type 2;"	"Diagnosis of renal and / or hepatic disease;Protein consumption above daily recommendation;Use of medications that interfere with the absorption of amino acids;Use of Insulin;
Contraindication for the practice of strength exercises;Practice of resisted exercises."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-3cwrdv	Asperisation of the dental cavity to improve the adhesion of composite resin restorations in patients with proximal teeth lesions of the gingiva	Not yet recruiting	Intervention	2018-02-27	<NULL>	<NULL>	1662	Asperisation of the dental cavity to maximize the adhesion of Composite Resin Restoration in patients with Non-Carious Cervical Lesions (LCNC) - using a Universal Adhesive System in the conventional and self-etching mode: Double Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-25	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3cwrdv	<NULL>	Patients older than 18 years will be included; presence of at least four LCNCs per patient, regardless of their location in the dental arch; adequate oral hygiene, and absence of driving difficulties that prevent adequate oral hygiene; absence of periodontal disease, active carious lesions and parafunctional habits, at least 20 teeth in function; absence of active staples of removable partial dentures in the teeth included in the research, and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Will be excluded: patients who do not agree with the terms of the survey; patients who do not feel motivated to participate in the research and maintain oral hygiene; patients who have difficulty attending the posterior controls of the restoration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-393m7m	Result of massage on recovery of athletes after street racing.	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1665	The effect of massage therapy on the recovery of runners after sports: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-30	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-393m7m	<NULL>	volunteers with age of 18 and 60, both men and women, have been practicing street racing for at least a year, accustomed to running more than 10 km continuously, to practice at least twice a week and not to have had muscle in last 6 months.	Not having heart disease, diabetes, hypertension, musculoskeletal diseases in the lower limbs in the last six months, without presence of cutaneous lesions in the region of the quadriceps muscle, not presenting severe metabolic or respiratory disorders, cramp, during the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-8rcfp6	Older women with urinary loss: program with Physical Exercise and Physiotherapy	Not yet recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1666	Older women with urinary incontinence: evaluation and intervention through physical exercise and physiotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8rcfp6	<NULL>	Being female, between 60 an75 years of age, without cognitive impairment, without pelvic dysfunction, with functional assessment of the pelvic floor (AFA) greater or equal 2 (presence of contraction of small intensity, but that sustains itself).	Those that present self-reported clinical restraint for the practice of resisted exercise, cardiovascular, osteoarticular or neurological activities will be excluded, being or practicing resistance exercises in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-2w7wkb	Chronic Heart Failure Remote Monitoring Application	Not yet recruiting	Intervention	2018-03-09	<NULL>	<NULL>	1682	HF in POCKET: Chronic Heart Failure Remote Monitoring Application	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Programa de Pós Graduação em Ciências Cardiovasculares	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-2w7wkb	<NULL>	Patients with a medical diagnosis of HF regardless of etiology; normal or decreased ejection fraction; older than 18 years; with functional classes I-III NYHA; participating in consultations at the specialized clinic	Patients with cognitive neurological sequelae self-reported or identified during the multidisciplinary consultation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-9c3ssc	Effect of telephone consultation associated with short messaging service (SMS) in patients with heart failure	Not yet recruiting	Intervention	2018-03-09	<NULL>	<NULL>	1683	Effect of telephone consultation associated with short messaging service (SMS) on self-care, adherence and quality of life of patients with heart failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-9c3ssc	<NULL>	Patients older than 18 years; with medical diagnosis of HF, regardless of etiology; have face-to-face service with the multiprofessional team of the specialized IC clinic, since the telephone consultation and the SMS service work with the reinforcement of face-to-face orientations; preserved or diminished ejection fraction; functional class I-III (NYHA) and signing of the informed consent form.	patients with cognitive neurological sequelae who did not have direct telephone contact	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-33wf46	Effect of ingestion of yacon syrup in human	Not yet recruiting	Intervention	2018-03-12	<NULL>	<NULL>	1684	Metabolic benefits of nutraceuticals in human health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Fundação Universidade Estadual do Ceará FUNECE	Empresa Brasileira de Pesquisa Agropecuária	https://ensaiosclinicos.gov.br/rg/RBR-33wf46	<NULL>	Women; between 20 and 40 years old; do not present chronic self-reported diseases; have a body mass index of eutrophy or obesity grade I; regular menstrual cycle.	Pregnancy or lactation; hysterectomy performed; current smoker or in the last 30 days; users of illicit drugs; daily consumption of ethanol higher than 15g; current or last 30 days use of hypoglycemic, lipid-lowering, antibiotic and anti-inflammatory medications, laxatives or weight-loss medications; have inflammatory diseases such as inflammatory bowel disease (Crohn&apos;s disease, ulcerative colitis); endocrinopathy carrier’s (cushing&apos;s syndrome, hypothyroidism), cancer carrier’s, having celiac disease or lactose intolerance; have constipation history; present current consumption and in the last 30 days of fiber and fructooligosaccharides supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-4ckqq9	The effect of treatment, sex, and severity of knee osteoarthritis on pain, physical function, quality of life and walking	Not yet recruiting	Intervention	2018-04-09	<NULL>	<NULL>	1699	Effect of treatment, level of severity and sex on pain, physical function, quality of life and march in individuals with knee of osteoartrite, having the emotional aspects as variable control	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-05	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4ckqq9	<NULL>	Diagnosis of osteoarthritis of the knee according to the criteria of the American College of Rheumatology; radiological evidence affecting one or more knee compartments, being uni or bilateral; knee pain for at least six months, with a score of three to seven according to the visual analogue scale; age between 50 and 70 years; medical certificate stating that the physical condition is satisfactory; literate	Other musculoskeletal disorders; chronic inflammatory diseases such as autoimmune diseases; diffuse pains; neuromuscular changes; mental illness; relative or absolute contraindications to the execution of the financial year; exacerbation of pain during treatment; irregularity of participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-4w2gd8	Treatment of Oral Opening Limitation in patients with Temporomandibular Joint problems using Laser Therapy	Not yet recruiting	Intervention	2018-04-12	<NULL>	<NULL>	1706	Treatment of Oral Opening Limitation in patients with Temporomandibular Disorder using Laser Therapy: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-4w2gd8	<NULL>	Patients diagnosed with temporomandibular disorder; myofascial pain; mouth opening limitation by the Research Diagnostic Criteria (RDC)	Pregnancy; clinical conditions of muscle spasm; myositis; contracture; polyarthritis; acute traumatic injuries; disc displacement without reduction; total or partial edentulous patients that include the anterior region; treatment with another health professional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-33dfy2	Treatment of wounds with laser and dye	Not yet recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1715	Study of Photodynamic Therapy(PDT) in the healing and repair of ulcerative lesions: literature review and clinical case study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação Universidade Federal do Amapá	Fundação Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-33dfy2	<NULL>	"Patients who agree and sign the informed consent form for said disclosure of the case. Patients with known contaminated wounds that need to be treated, whose criteria will be defined by the professional responsible as well as choosing for this therapeutic modality .
Patients older than 18 years."	"Patients with underlying diseases such as diabetes and hypertension.
Patients known to be immunocompromised as oncological under treatment, HIV positive sera, AIDS patients.
Patients who require a systemic medication that is constant or sporadic. In order to evaluate the effect of the therapy first on the repair proposal, it is opted methodologically for its evaluation without intercurrent factors, to
in a later study to associate the local effect of the technique in a specific group of patients, even if there were studies in patients under the conditions of the exclusion criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9bb2pt	Evaluation of the Efficacy and Safety of a product for health, through the Evaluation of a Dermatologist and Application of Questionnaire	Not yet recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1719	Evaluation of subjective dermatological clinical efficacy and safety with healthcare product appreciability_TCI	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-05	Ipclin - Pesquisa Clínica Integrada	TCI Laboratório Biotecnológico LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-9bb2pt	<NULL>	Age between 18 to 65 years; Female or male; Phototypes I to IV; Subjects susceptible to the appearance of wound and/or contact dermatitis; Able to follow the guidelines and reliable to respect the restrictions of the protocol.	Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn); Active dermatoses (local and disseminated) that may interfere with the results of the study; Pregnant or lactating women; History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines; Participants with a history of allergy to the material used in the study; History of atopy; History of conditions aggravated or triggered by ultraviolet radiation; Immunodeficiency carriers; Renal, cardiac or hepatic transplanted; Intense sun exposure or tanning session up to 15 days prior to initial assessment; Prediction of intense sun exposure or the tanning session during the period of study conduction; Forecast to take a bath, pool or sauna during the study; Participants who practice water sports; Use of the following topical systemic medications: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection; Treatment with acid vitamin A and / or its derivatives orally or topically up to 01 month before the start of the study; Prediction of vaccination during the study or until 03 weeks before the study; Be participating in another study; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study; History of absence of adherence or unwillingness to adhere to the study protocol; Professionals directly involved in the accomplishment of this protocol and their relatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9m387t	Effect of Exercises and Abdominal Massage compared to Standard Treatment in the Control of Bloating in Women with Irritable Bowel Syndrome	Not yet recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1720	Effect of Kinesiotherapy and Visceral Manipulation compared to Standard Treatment in the Control of Abdominal Distension in Women with Irritable Bowel Syndrome: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9m387t	<NULL>	Women complaining of abdominal distension, aged 18 years or over, diagnosed with Irritable Bowel Syndrome	Acute organic or obstructive gastrointestinal disease, inability to assume the four support position, morbid obesity, psychiatric disorders, alcoholism, psychoactive drug use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-2685h6	Evaluation of the Preventive Effect of Pain by the Use of Melatonin During Female Sterilization Surgery	Not yet recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1724	Evaluation of Melatonin Analgesic Effects Used in the Perioperative Period of Bilateral Tubal Ligation: Randomized Clinical Trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Hospital Municipal Pedro I	https://ensaiosclinicos.gov.br/rg/RBR-2685h6	<NULL>	Women scheduled for bilateral tubal ligation; age between 18 and 65 years.	Pregnant patients; history of intolerance or chronic use of opioids or other medications proposed in the study; chronic use or known melatonin intolerance; addicted to alcohol or drugs; use of analgesics, opioids or not, within 24 hours prior to the procedure; inability to provide informed consent and low easily identifiable cognition; patients who present contraindication to neuroaxis blockade.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4x7dny	The effectiveness of Happy Child Program on child development	Not yet recruiting	Intervention	2018-04-19	<NULL>	<NULL>	1726	Impact Evaluation of the Happy Child Program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pelotas	Ministério do Desenvolvimento Social e Agrário	https://ensaiosclinicos.gov.br/rg/RBR-4x7dny	<NULL>	Children under six year old.	Families whose parents / guardians are under the age of 18 living alone; families in which the target child of the program was born twin; children with physical or cognitive disabilities reported by those responsible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-6yfcbm	Red and Orange Light to Treat Wrinkles	Not yet recruiting	Intervention	2017-07-19	<NULL>	<NULL>	1727	Efficacy of Phototherapy with Red and Amber LEDs for treatment of Facial Aging	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6yfcbm	<NULL>	Women will be included; 40-65 years old; with skin phototypes II, III and IV on the Fitzpatrick scale and signs of aging III and IV in Glogau scale.	Will be excluded from the study male patients; women under the age of 40 and over 65; with thyroid changes (hyperthyroidism or hypothyroidism) and who are not taking the treatment or taking the medication for less than 1 year; who have received facial fillers in the last 12 months; who are performing some facial aesthetic procedure; that they are taking retinoic acid or any vitamin A derivative (tretinoin or isotretinoin, topical or oral); who are using cosmetics or medications that may increase skin photosensitivity; that they present some skin pathology, such as acne, psoriasis, vitiligo, etc .; who presents big laterality of skin aging; professional drivers; who have undergone bariatric surgery or who are under strict diet; that they are making use of some type of supplement (topic or oral) for improvement of the skin conditions; in the period of pregnancy and / or lactation; patients who are not assiduous in the sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-4vt6th	Evaluation of a Molecular Test for the rapid detection of of microorganisms in patients with Generalized Infection (Sepsis)	Not yet recruiting	Observational	2018-04-30	<NULL>	<NULL>	1739	Evaluation of a Molecular Method for the rapid detection of pathogens in patients with Sepsis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Fundação Oswaldo Cruz	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-4vt6th	<NULL>	Patients with suspicion of sepsis that required hospitalization in an intensive care unit	"Pregnant patients;
Patients younger than 18 years.
Dying patients, in palliative care or with an expectation of ICU stay less than 24 hours."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-6k9rgc	Laser Therapy on Pain Intensity of patients with advanced knee Osteoarthritis	Not yet recruiting	Intervention	2018-05-01	<NULL>	<NULL>	1744	Photobiomodulation on Pain Intensity of patients with Grade 4 of Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6k9rgc	<NULL>	Age between 55-85 years old; diagnosed with knee osteoarthritis (unilateral or bilateral) for at least 2 years; have pain in at least 3 of the following actions: go up and down at stairs, kneeling, sit and stand up, running, and standing up for at least 2 minutes; more than 4 points (moderate) at numeric rating scale; and have grade 4 at Kellgren-Lawrence grading system.	Uncontrolled diabetes mellitus; not treated arterial hypertension; neurological deficit (motor or sensory); diagnosed with cancer; fibromyalgia; previous injection of hialuronic acid (and/or invasive therapies); or refusing to  participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9t4xxk	Evaluation of the black mulberry effects under the symptoms of menopause	Not yet recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1762	Evaluation of Morus nigra L effects on climacteric women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Hospital Universitário da Universidade Federal do Maranhão/HU/UFMA	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-9t4xxk	<NULL>	Women aged between 35 and 65 years old who present climacteric symptoms,among them hot flushes; paraesthesia; insomnia; nervousness; depression; fatigue; arthralgia; headache; palpitation and ringing in the ear	Women with previous or family history of breast cancer; ovarian cancer or endometrial cancer; with hepatic failure; porphyria; abnormal endometrial bleeding; deep vein thrombosis and coronary artery disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3cbzwy	Effectiveness of Physical Measures versus Cabergoline for Lactation Inhibition	Not yet recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1768	The effect of Breast Binding with Bandages and Application of Ice Pack versus Cabergoline for lactation inhibition	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-15	Instituto de Medicina Integral Prof. Fernando Figueira	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-3cbzwy	<NULL>	Women with up to 24 hours postpartum; gestational age at delivery of 20 weeks or more; indication for inhibition of lactation: late fetal loss, neomorto up to 24 hours, breast cancer or leukemia in pregnancy or in case of severe maternal morbidity	"Hypertensive syndromes in current gestation; known hypersensitivity to cabergoline; history of cardiac valve disease;
history of retroperitoneal or pulmonary fibrotic disease"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-33mjbg	Combined use of Propolis with Antiretroviral Therapy and possible health benefits of HIV-infected individuals	Not yet recruiting	Intervention	2018-05-09	<NULL>	<NULL>	1773	Association of Propolis to Antiretroviral Therapy for HIV-infected individuals: innovation in treatment and possible benefits in immunological, inflammatory and oxidative stress parameters	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Instituto de Biociências de Botucatu - UNESP	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-33mjbg	<NULL>	To have confirmed HIV infection and use of cART with adequate viral suppression for at least three years; have a minimum age of 20 and a maximum of 50, and sign a Consent Form.	cART patients for more than 10 years and / or under rescue therapy; vertical transmission; patients with cancer, diabetes mellitus, cardiovascular or autoimmune diseases; transplanted; patients who exercise regularly; pregnant or lactating women; presence of co-infections such as tuberculosis, viral hepatitis, toxoplasmosis, among others; genetic diseases; treatment with anxiolytics or antidepressants; vitamin supplementation; users of illicit drugs, active smokers and alcoholics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9g8d46	Cardioprotective effects of Electro-acupuncture	Not yet recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1782	Cardioprotective potential of Transcutaneous Electro-Stimulation in Acupuncture points in the preoperative Heart Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9g8d46	<NULL>	All patients between 18 and 80 years of age; who undergo an exclusive surgical procedure of valve replacement; and are hospitalized preoperatively at the National Institute of Cardiology will be eligible for the study.	Patients who present in the initial evaluation will be excluded from the study; pregnancy; presence of a cardiac pacing device; intermittent cardiodesfibrillator; hearing devices; skull trauma; brain injury; status epileptics; tetanus; adult respiratory distress syndrome; chronic liver disease; chronic kidney diseases; patients taking Sulfonylurea; Glibenclamide; who have already had previous heart surgery; cognitive alterations that impede the accomplishment of the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-2cwy5d	Effect of a Therapy for discomfort in the musculature of the neck region in adults	Not yet recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1785	Effect of Radiofrequency in the contract of the  trapezius upper muscle in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-14	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2cwy5d	<NULL>	Adult patients between 18 and 40 years of age; pain and muscle contracture in the upper trapezius muscle	Subjects with altered sensitivity; intraorganic metal implants; osteosynthesis; electric implants; pregnant women; subjects on drug therapy for blood circulation (use of vasodilators or anticoagulants); hemophiliacs; subjects with outbreaks of infection and with fever; elitist neoplastic disease; in topical or non-muscle relaxation treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-84zdp6	Effect of physiotherapeutical treatment on hip pain in women	Not yet recruiting	Intervention	2018-05-15	<NULL>	<NULL>	1795	Randomized clinical trial: The effect of a physiotherapy protocol in Greater trochanteric pain syndrome in women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Estadual Paulista, Faculdade de Filosofia e Ciências	Universidade Estadual Paulista, Instituto de Biociências	https://ensaiosclinicos.gov.br/rg/RBR-84zdp6	<NULL>	Clinical diagnosis of major trochanter pain syndrome, chronic lateral pain in the hip greater than or equal to 3 months, presenting pain (4/10) in the visual analogue scale, tenderness in the trochanter region (4/10), pain during daily activities, pain in at least 1 of the 7 provocative clinical tests of pain, which is intended to transmit compressive or tension forces in the tendons of the abductor gluteal muscles. To present age and gender comparable to the intervention group	Presenting a body mass index more than 36 kg / m2, received some type of invasive intervention to reduce pain in the region evaluated in the last year, physiotherapeutic intervention in the last three months, present any limitation in the range of motion of the regions of the column, hip or MMII that disables gait or testing, any disease that affects the neuromuscular system or that may prevent collection, surgery on the spine or hip, any infectious condition, any neoplasia or can not commit to the weeks of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-5m3s2s	Effects of physical exercise associated with music on behavioral, functional and mental aspects in older people with dementia who live in nursing homes	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1800	Behavioral, functional and mental factors and the Effects of Physical Exercise associated with Music in institutionalized older people with Dementia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-27	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5m3s2s	<NULL>	People aged 60 years old and over; living in nursing homes; dementia diagnosis; availability to participate in the proposed evaluations.	Severe and uncorrected auditory disorder that prevents the participant from hearing music; any cardiovascular or infectious comorbity described in the absolut contraindications list of Physical Activity Readiness Medical Examination (2002) (acute infectious disease, dissecting aneurism of aorta, severe aortic stenosis, congestive heart failure, unstable angina, acute myocardical infarction, acute myocarditis, pulmonary or acute systemic embolism, thrombophlebitis, ventricular tachycardia and other dangerous arrhythmias).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-67h649	Comparison between two IUD immediate postpartum	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1805	Comparison between copper IUD (intrauterine device) and levonogestrel-releasing system immediate postpartum - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-67h649	<NULL>	Age between 18 and 43 years; gestational age at delivery greater than or equal to 37 weeks; hemoglobin major than 8.0 during prenatal care; desire to use IUD as contraceptive method; immediate Postpartum of single gestation	Diagnosis or suspicion of ovular infection; diagnosis of any other infection (anywhere); active STD (sexually transmitted disease); uterine malformation (bicorn, septate);uterine myomatosis that deforms the cavity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-5s4czx	Acupuncture to treat the symptoms of Premenstrual Syndrome - randomized controlled study	Not yet recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1807	Acupuncture as a therapeutic resource for treatment of symptoms of Premenstrual Syndrome - a randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Universidade de Mogi das Cruzes	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-5s4czx	<NULL>	Will include women aged between 18 and 40 years; presence of at least one physical symptom and one emotional symptom in the pre-menstrual and/or menstrual period observed in the two cycles prior to the study in non-users or users of oral contraceptives and who present three regular menstrual cycles before the study.	Women who use anxiolytics or antidepressants will not be included; with liver diseases; carriers of coagulation disorders, oophorectomized; carriers of cancer or serious diseases; carriers of psychiatric illnesses; history of radiation therapy or chemotherapy; illicit drugs and/or excessive alcoholic beverages, pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-9wfsyj	Ideal time for Umbilical Cord Tightening for the baby	Not yet recruiting	Intervention	2018-05-17	<NULL>	<NULL>	1811	Ideal time for Umbilical Cord Clamping for the newborn: a controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-25	Universidade Federal de Alagoas	Escola de Enfermagem e Farmácia	https://ensaiosclinicos.gov.br/rg/RBR-9wfsyj	<NULL>	Parturient in the period of expulsion of normal labour at normal risk and cephalic presentation; with gestational age greater than or equal to thirty seven weeks calculated by the date of the last menstrual period and or by the result of the precocious ultrasonography until the twentieth week; being this age of the newborn confirmed through Capurro method after birth. Newborns of normal delivery with cephalic presentation with an Apgar score seven in the fifth minute, which considers the characteristics of respiratory rate, heart rate, colour, muscle tone and irritability of the newborn at birth	Newborns presenting: maternal-infant Rh factor incompatibility; Neonatal anoxia; Neonatal malformations and parturient with fetus without vitality or in fetal distress; parturients who present any clinical or obstetric complications that justify the accomplishment of cesarean delivery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-3nfxvx	Randomized clinical trial comparing the use of high-flow nasal catheter vs. traditional nasal catheter after anesthesia for orotracheal intubation of preoperative patients with traumatic orthopedic surgeries	Not yet recruiting	Intervention	2018-05-17	<NULL>	<NULL>	1812	Randomized clinical trial comparing the use of the High flow nasal cannula (HFNC) vs. Traditional nasal cannula after anesthetic induction for orotracheal intubation of preoperative patients with Traumatic orthopedic surgeries	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-31	Hospital Universitário da Universidade Federal de São Paulo	Hospital Universitário da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3nfxvx	<NULL>	Patients of both sexes will be included; older than 18 years; with indication of traumatic orthopedic surgeries.	Patients younger than 18 years will be excluded; carriers of previously known chronic lung disease; and patients with hemodynamic instability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-66yr4x	Effects of training in lower limb exercise in patients after cardiac surgery	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1816	Effects of training cycle ergometer in patients after cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-66yr4x	<NULL>	cardiac post-surgical patients hospitalized in the ICU; of both sexes; aged 18 years or older; level of light sedation; without sedation or who are level-2 to zero by the sedation scale of Richmond Agitation Sedation; vasoactive and / or inotropic drugs less than 0.5 mg / kg / min; mean arterial pressure between 60 and 100 mmHg; heart rate between 60 and 120; muscle strength 3 by the manual muscle strength test Medical Research Council (MRC); functional independence prior to hospitalization. And the ventilatory parameters used are: FiO2 bigger than 60%; PaO2 bigger than 70mmHg; PEEP less than 8; SpO2 bigger than 90%; f less than 35irpm	Those who give up the research; evolve to death or need to be reopened surgically	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-2sk64p	Effect of a small book on home care of preterm infants	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1817	Effect of an educational technology on the home stimulation of preterm infants: clinical, non-randomized trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Enfermagem da Universidade de São Paulo	Hospital e Maternidade Rede D'OR São Luiz - Unidade Anália Franco	https://ensaiosclinicos.gov.br/rg/RBR-2sk64p	<NULL>	Family of children born with any level of prematurity who have been hospitalized in Neonatal Intensive Care Unit	Non-resident family members in the municipality of São Paulo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-67zvpn	Protective test to prevent nose lesions of babies that require oxygen supplied through continuous positive airway pressure with prongs	Not yet recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1823	Efficacy of a nasal protector model in prevention of local lesions for newborns utilizing continuous positive airway pressure with prongs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-67zvpn	<NULL>	Newborns hospitalized in neonatal intensive or intermediary care units of the institutions chosen as place of this study; independent of city or institution of birth, which requiring positive pressure ventilatory support associated with the continuous positive airway pressure with nasal prongs interface; on admission or after initial invasive mechanical ventilation	Newborn with pre-existing nasal deformities detected during physical examination; newborn with congenital malformations of upper respiratory tract; newborn with large congenital or macrosomia anomalies; newborn with persistent physiological instability; newborn with coagulation disorder, or shock; newborn that terminates the use of positive pressure ventilatory support with continuous positive airway pressure with nasal prong before the period established for process monitoring	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-882rg2	The role of nurses in relation to nursing protocols for better care of patients in the emergency room in Brazil	Not yet recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1845	Nurses&apos; knowledge and practices in the face of the challenge of using the systematization of nursing care as an instrument of assistance in a first aid in Brazil	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-882rg2	<NULL>	Nurses filled in the Hospital; Minimum six months experience in the service	Professionals on vacation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-29rzdh	Impact assessment of Criança Feliz Program and Book Loans&apos; Program	Not yet recruiting	Intervention	2018-05-28	<NULL>	<NULL>	1853	Impact assessment of Household Visits and Book Loans	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-21	IDados Estudos Pesquisa e Informação	IDados Estudos Pesquisa e Informação	https://ensaiosclinicos.gov.br/rg/RBR-29rzdh	<NULL>	Families with children under 3 years old; families with pregnant women.	There are no exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-759bvb	Analysis on the maintenance of the bone around the implants with threads in their neck. Study in humans.	Not yet recruiting	Intervention	2018-05-28	<NULL>	<NULL>	1854	Evaluation of the remodeling of bone crest and marginal bone around implants with cervical microthreads. Clinical study in humans.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Centro Universitário de Araraquara	Centro Universitário de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-759bvb	<NULL>	To be included in the study, the patient should present at least two edentulous areas with a minimum healing period of 3 months post-extraction and without the need for reconstructive therapies. These patients should have good periodontal condition and good general health status.	The exclusion criteria will be: need for prior tissue reconstruction, smokers, alcohol users, drug users, uncontrolled diabetics, oral or intravenous bisphosphonate therapy, bruxism or parafunction patients, or patients with systemic diseases that are known to interfere osseointegration of the implants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-2jxgm2	Manufacture of single crowns on implants through angled abutments	Not yet recruiting	Intervention	2018-05-29	<NULL>	<NULL>	1856	Angled titanium base abutments for the reconstruction of anterior implants with screw-retained single crowns: A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2jxgm2	<NULL>	At least 18 years; Missing tooth in the anterior maxilla; Need for a single implant crown; Presence of one adjacent tooth at the implant site; Presence of antagonist; Adequate oral hygiene; Capability to comply with the study procedures; Signed Informed Consent Form	Ridge preservation procedure after tooth extraction performed; Pregnant or lactating women; Known or suspected non-compliance, drug or alcohol abuse; Smokers (more than 10 cigarettes/day); Currently taking drugs that influence bone metabolism; Use of bisphosphonates in the last 4 years; History of malignancy, radiotherapy or chemotherapy for malignancy in the past 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-3wn6tf	Effect of physical and mental training, involving two tasks together, on the functionality of the elderly	Not yet recruiting	Intervention	2018-05-31	<NULL>	<NULL>	1862	Efect of motor-cognitive training (double task) in the functionality of elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal Do Triângulo Mineiro	Universidade Federal Do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-3wn6tf	<NULL>	Minimum score of 18 points in the Mini-Mental State Examination (MMSE); be literate; presenting visual acuity preserved or corrected	"Inability to maintain orthostatism and to wander without the use of any auxiliary gait device; those who are submitted to another type of physiotherapeutic intervention concomitantly; participants during the study period: changes such as significant or chronic orthopedic pain, joint deformities,
three consecutive service sessions, any of the non-inclusion characteristics already mentioned"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-8shb3h	Effects of Muscular Massage with Instruments on the operation of the heart of young women practicing weight training	Not yet recruiting	Intervention	2018-05-31	<NULL>	<NULL>	1863	Effects of Instrumental Myofascial Release on cardiac autonomic modulation in young women practicing weight training	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Centro Universitário de Formiga - Minas Gerais	Centro Universitário de Formiga - Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8shb3h	<NULL>	40 young women; age between 18 and 24 years; exercise bodybuilding at least three times a week for a minimum of six uninterrupted months; present vital signs such as blood pressure, heart rate, oxygen saturation and respiratory rate within the normality patterns at the time of data collection; resting heart rate between 50 and 80 beats per minute (bpm); agree and sign the Informed Consent Form	Chronic obstructive pulmonary disease; Diabetes Mellitus; Arterial hypertension; Thyroid diseases; Heart diseases; patients with pacemakers; users of medications Diuretics and Beta-blockers; obese individuals; dermatological problems; skin lesions; edema; changes in blood coagulation; vascular hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-9z95r5	Traumatic stress: Prevalence and Intervention in Groups Exposed to Critical Incidents	Not yet recruiting	Intervention	2018-06-04	<NULL>	<NULL>	1868	PTSD: Prevalence and Assessment of an Intervention in Groups Exposed to Critical Incidents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Programa de Pós-Graduação em Psicologia da Universidade Federal de Santa Catarina	Corpo de Bombeiros Militar de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9z95r5	<NULL>	Volunteers belonging to a group exposed to critical incidents; 18 year or above; clinical or subclinical level of posttraumatic stress disorder	Volunteers who have suffered multiple-incident childhood trauma; volunteers who have previously been diagnosed with mental disorders other than posttraumatic stress disorder, acute stress disorder, or depression- or anxiety-related disorders; volunteers who have received medical, psychiatric or psychological treatment for traumatic stress disorders, depression or anxiety in the year preceding the trail; volunteers who are presently receiving medical, psychiatric or psychological treatment for mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-243frc	Evaluation of the ruler with measurements of the cervix as a learning resource	Not yet recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1869	Evaluation of the indicator of cervical dilatation as a didactic instrument	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-243frc	<NULL>	To belong to the course of Obstetrics of the School of Arts, Sciences and Humanities of the University of São Paulo; be regularly enrolled in the 5th or 7th semester; not having completed the course Integrated Curricular Internship III (Assistance in childbirth and birth)	Have experience of the vaginal touch on the manikin; no agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-4t6szp	The Impact of Dance as a Complementary Therapy on the Quality of Life of Oncologic Patients	Not yet recruiting	Intervention	2018-06-07	<NULL>	<NULL>	1881	Clinical Trial: The Impact of Dance as Adjuvant Therapy on the Quality of Life of Oncologic Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Associação de Combate ao Câncer em Goiás	Financiamento Próprio dos Pesquisadores	https://ensaiosclinicos.gov.br/rg/RBR-4t6szp	<NULL>	Women in cancer treatment at Hospital Araújo Jorge ACCG; residents of the state of Goiás; with medical authorization to participate in the project	Women who although they are in cancer treatment at Hospital Araújo Jorge ACCG do not have medical authorization to participate in the intervention. And men in cancer treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8g2rjk	Daily Oral Hygiene in Inpatients in Cardiology Unit	Not yet recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1893	Daily Oral Hygiene in Inpatients in Cardiology Unit: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8g2rjk	<NULL>	Be waiting for cardiac surgery; 40 years or older at the time of data collection; Be hospitalized more than one day at the cardiology unit; Be in good physical and mental condition to perform intraoral clinical examination	Use of immunosuppressive drugs or antibiotics; Have contraindications for treatment of another disease; Have had radiotherapy treatment near the head and neck region; Patients with a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-7gyntj	Use of resin sealant for caries prevention and treatment	Not yet recruiting	Intervention	2018-06-14	<NULL>	<NULL>	1896	Caries prevention with the use of resinous materials: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Universidade Federal do Maranhão - UFMA	Fundação de Amparo a Pesquisa do Estado do Maranhão - FAPEMA	https://ensaiosclinicos.gov.br/rg/RBR-7gyntj	<NULL>	Individuals between 9 and 14 years old; With the presence of at least two 2nd permanent molars in infraocclusion (eruption stages 2 and 3); (ICDAS 0,1, 2 and 3); with pulp vitality; free of restorations / sealants on either side of the tooth that will be treated	Pre-young people who present with periodontal disease; do not present systemic alterations; that report previous allergies to restorative materials; who do not wish to participate in the study or who are not authorized by the parents / guardians	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-3g22mg	Effect of video for grandparents in the promotion of breastfeeding	Not yet recruiting	Intervention	2018-06-14	<NULL>	<NULL>	1898	Effect of the use of educational technology for grandparents in the promotion of breastfeeding	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3g22mg	<NULL>	Grandparents whose firstborn daughters or daughters-in-law are in the third trimester of pregnancy will be included and regularly perform prenatal consultations by registered nurses, who are literate and plan to breastfeed their babies.	Grandparents whose daughters, daughters-in-law or grandchildren present some condition known to contraindicate breastfeeding and those with risk pregnancies will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-57qbjv	Clinical trial of Methotrexate associated to Hydroxyurea versus placebo and Hydroxyurea in patients with sickle cell disease	Not yet recruiting	Intervention	2018-06-18	<NULL>	<NULL>	1909	Phase II, randomized clinical trial on the anti-inflammatory effect of Methotrexate associated to Hydroxyurea versus placebo and Hydroxyurea in pediatric patients and young adults with sickle cell disease and vaso-occlusive symptoms	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-08-01	Centro Infantil Boldrini	Centro Infantil Boldrini	https://ensaiosclinicos.gov.br/rg/RBR-57qbjv	<NULL>	Sickle Cell Disease patients; aged 08-30 years; patients who have vaso-occlusive pain episodes despite the regular use of hydroxyurea in the clinically-adjusted dose for a period equal or superior to 24 weeks	Absence of a signed Subject Information and Consent Form/Parents’ or legal guardian’s Informed Permission; renal or hepatic insufficiency; infection at enrollment time; pregnancy or breastfeeding; regular and/or frequent blood transfusions; refusal of contraceptive measures by females in reproductive age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-6gbzw6	Fish oil supplementation during pregnancy to prevent postpartum depression and possible effect on breastfeeding, growth and development of the child	Not yet recruiting	Intervention	2018-06-19	<NULL>	<NULL>	1913	Omega-3 supplementation during pregnancy to prevent postpartum depressive symptoms and possible effect on breastfeeding, child growth and development	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6gbzw6	<NULL>	Adult pregnant women; without multiple gestation; without diagnosis of high risk gestation; without previous supplementation with fish oil; without fish oil intolerance; without current or pre pregnant psychological treatment; without the use of psychiatric medications	Participants with postpartum depression score greater than or equal to 10 and need for medical treatment and / or medical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-2ss28r	Associations Among Bed Bath, Sleep and Body Temperature in Intensive Care Patients	Not yet recruiting	Observational	2018-06-20	<NULL>	<NULL>	1918	Associations among Bed Bath, sleep characteristics and body temperature in the critically ill: A cross-sectional study with the Bispectral Index®	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Hospital de Clínicas da Universidade Federal do Paraná	Instituto de Tecnologia para o Desenvolvimento - Lactec	https://ensaiosclinicos.gov.br/rg/RBR-2ss28r	<NULL>	Adult and elderly critically ill individuals; admitted at the intensive care unit 2 of the Hospital de Clínicas da Universidade Federal do Paraná; with mild and moderate gravity diseases; with perspective of spending the next night at that unit; and that are able to understand and accept the terms of the Informed Consent.	Individuals with severe organ disfunction; wich compromise the comprehension and acceptance of the terms of the Informed Consent; individual who don&apos;t accept these terms; those identified as delirious; those who decide to leave the study after the inclusion. Individuals may decline participation at any time independently of justification.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8zm6cv	Evaluation of Dental Sensitivity and Color Changes after Dental Bleaching in adults and adolescents	Not yet recruiting	Intervention	2018-06-21	<NULL>	<NULL>	1919	Evaluation of Dental Sensitivity and Efficacy of Dental Whitening in adolescent and adult patients: randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-06	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Faculdade de Odontologia de Pernambuco - Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8zm6cv	<NULL>	To be 12 to 20 or 40 to 50 years of age, have all permanent anterior teeth; have coloration above A2 on the VITA Classical Shade guide	To present allergy to the bleaching agent; to start orthodontic treatments, to perform restorative procedures on the buccal surface of elements 11, 21, 13, 23, 31, 41 and/or 33; not to complete the bleaching treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-2xn3g6	Impact of active video game on adolescent health	Not yet recruiting	Intervention	2018-06-21	<NULL>	<NULL>	1920	Impact of exergame on cardiorespiratory function, macro and microcirculation of overweight adolescents: a randomized intervention study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-05	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2xn3g6	<NULL>	To be enrolled and attending the classes from the 5th to the 9th year of the public school network of the urban area of ??Campina Grande-PB selected for the study; being in the age group of 10 to 18 years; have nutritional status characterized as being overweight or obese.	"Present some motor (although temporary) or mental limitation that impedes the participation in the activities of the intervention and / or the accomplishment of the exams, as the pulmonary function tests; have any severe metabolic changes that require the use of medications or specific treatment that alter the metabolism of the lipid profile; have asthma with a recent crisis (two months prior to data collection) and / or report of exercise-induced bronchospasm; not being, at the time of the research, overweight treatment, and active video game users; 
for women, being pregnant or breastfeeding."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-758cbn	A Phase I/II open-label study at a single research center to evaluate the safety, tolerability, and effects of RGX-111 gene therapy given directly into the central nervous system in subjects with severe mucopolysaccharidosis type I	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1925	A phase I/II single center, open-label study to evaluate the safety, tolerability,  pharmacodynamics and preliminary efficacy of intracisternal RGX-111 gene therapy in subjects with severe mucopolysaccharidosis type I	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2018-11-01	Hospitais de Clínicas de Porto Alegre	REGENXBIO Inc.	https://ensaiosclinicos.gov.br/rg/RBR-758cbn	<NULL>	A male or female less than 3  years of age; The subject’s legal guardian(s) is(are) willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures; Has a documented diagnosis of severe Mucopolysaccharidosis Type I (MPS I) -Hurler confirmed by homozygosity or compound heterozygosity for mutations exclusively associated with the severe phenotype; Has an intelligent quotient (IQ) score of  greater than or equal to  55; Has sufficient auditory and visual capacity, with or without aids, to complete the required protocol testing and willing to be compliant with wearing the aid, if applicable, on testing days	"Has a contraindication for an intracisternal injection (IC); Has any neurocognitive deficit not attributable to Mucopolysaccharidosis Type I (MPS I) or has a diagnosis of a neuropsychiatric condition that may, in the opinion of the PI, confound interpretation of study results; Has any contraindication to lumbar puncture; Has undergone hematopoetic stem cell transplantation (HSCT); Has had prior treatment with an Adeno-associated virus (AAV)-based gene therapy product; Has received intrathecal (IT) laronidase at any time and experienced a significant Adverse event (AE) considered related to IT administration that, in the opinion of the PI, would put the subject at undue risk; Has a platelet count less than 100,000 per
microliter; Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 3 × upper limit of normal (ULN) or total bilirubin greater than 1.5 × ULN at screening, unless the subject has a previously known history of Gilbert’s syndrome; Has a history of human immunodeficiency virus (HIV) or hepatitis B or hepatitis C virus infection, or positive screening tests for hepatitis B surface antigen or hepatitis B core antibody, or hepatitis C or HIV antibodies"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-3ft2rq	Effects of robotic therapy on the gait of post-stroke individuals	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1927	Effects of robotic therapy on the gait kinematics of chronic hemiparetic individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-30	Universidade de São Paulo	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3ft2rq	<NULL>	The subjects who present the last episode of stroke, single, unilateral and ischemic for more than 6 months, without documented changes in motor or sensory impairment, will be included in the study; muscle tone or reflex activity in the 3 months prior to the subject&apos;s participation in the study; the level of spasticity equal to or less than 2 in the Modified Ashworth Scale for lower limbs, allowing individuals to perform the test, 3 to 5 according to the Functional Ambulation Category. The ankle joint should be kept in a neutral position and without deformities. In addition, they must present a minimum score in the Mental State Mini Exam according to the volunteer&apos;s schooling. The Beck Depression Scale inventory will be used to identify individuals with depression. Individuals with values greater than 63 will be excluded. The age range will be between 40 and 70 years.	Subjects with severe cardiovascular diseases, heart failure, arrhythmias or angina pectoris, will be excluded from the study; rheumatic diseases; body mass index greater than 28 kg/m² changing the reliability of the EMG data; other orthopedic or neurological diseases that compromise the collection of data through the isokinetic test and cognitive or communication deficiencies that make it impossible to perform the procedures; painful contractures or deformities in the paretic ankle; shortenings that make it impossible to perform tests or promote pain; show the range of motion less than 10o for dorsiflexion and 20o for plantar flexion according to goniometry; cerebellar ataxia; sensory deficit defined by the loss of proprioception of the first phalangeal metatarsus; hemi- sensorial neglect on neurological examination; various neurological disorders; participation in rehabilitation programs; the presence of pain during the procedures will be considered exclusion criterion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8bq75m	Research and stimulation on the use of eight practices that promote health in the city of Uberaba MG	Not yet recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1933	Inquiry use of eight practices that promote health in the municipality of Uberaba MG	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal Do Triângulo Mineiro	Universidade Federal Do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8bq75m	<NULL>	Both sexes; age above 18 years; literate; with a minimum score of 23 in the Mental State Mini Exam; agree to participate in the meetings; sign consent form	Give up the study; not answer the questionnaires completely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-94c26n	Noninvasive brain stimulation to improve the gait of children with cerebral palsy	Not yet recruiting	Intervention	2018-06-29	<NULL>	<NULL>	1944	Transcranial electrostimulation to facilitate gait rehabilitation of children with spastic cerebral palsy: cross-over randomized clinical trial, placebo-controlled, double-blinded	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade de Sorocaba	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94c26n	<NULL>	The children will be screened for participation in the study according to the following criteria:diagnosis of spastic CP confirmed by clinical examination; to obtain magnetic resonance imaging of the brain performed no more than two years before the beginning of the intervention; demonstrating lesion in the pyramidal system; without compromising the extrapyramidal system and cerebellum; age between five and 15 years; children levels I, II and III of GMFCS; children who have a muscular form degree equal to or greater than three in the flexor and extensor muscles of the trunk, hips and knees;  degree of spasticity of less than three in the Modified Ashworth Scale; agreement of those responsible by signing the Term of Free and Informed Consent.	Children will be excluded if are diagnosed with epilepsy or have had seizures at least 12 months before the beginning of the study, present neurological, neuromuscular or syndromic diseases associated with brain injury; have undergone orthopedic or neurological surgeries in the 12 months prior to the intervention; have undergone neurolithic blockade in the 12 months prior to intervention; present orthopedic deformities with surgical indication; have brain implants or have performed some neurosurgical procedure; have metallic implants in the regions of head, neck, thorax and / or upper limbs, have hearing aids; children with a degree of collaboration incompatible with the adequate performance in the activities proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2gwjgj	Use of Virtual Immersion Therapy to improve the Posture, Balance and Walking of children with  Hearing Loss	Not yet recruiting	Intervention	2018-07-02	<NULL>	<NULL>	1948	Effectiveness of a training program using Virtual Immersion Therapy to improve Postural Control stability, Body Balance and Gait of children with Sensorineural Hearing Loss: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal de Pernambuco - UFPE	Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-2gwjgj	<NULL>	The children must be enrolled or in attendance in the collaborating institutions of this study; to be in the age group between 7-11 years of age; to present, through a medical report, diagnosis of sensorineural hearing loss; to have degrees of hearing loss (severe to profound) (values higher than 70 dB); dominate the Brazilian sign language, this last criterion will be used to ensure that all the commands referring to the demands of the methodology will be understood by all children, we also point out that, all children have access to learning the Brazilian language of signs in your institution of education and the child must undergo exams of auditory and vestibular function	Present any associated physical, neurological or cognitive deficits (except vestibular dysfunction); children with hearing loss using cochlear implants; Discrepancy in lower limbs greater than 2 centimeters; Children who are engaged in recreational or sports activities on a regular basis, such as ballet, soccer, swimming, or other sports training at school	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8y49vf	Leukocyte- and Platelet-Rich Fibrin for preventing Osteoradionecrosis following Tooth Extraction	Not yet recruiting	Intervention	2018-07-02	<NULL>	<NULL>	1949	Leukocyte- and Platelet-Rich Fibrin for Preventing Osteoradionecrosis following Tooth Extraction: an exploratory study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-31	Universidade Ibirapuera	Hospital Heliópolis	https://ensaiosclinicos.gov.br/rg/RBR-8y49vf	<NULL>	Previous 3D conformational radiotherapy for head and neck cancer; total radiotherapy dose from 50Gy to 70Gy; at least 18 years of age; able to undergo dental surgery.	Disease recurrence (cancer); drugs that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; diseases that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; tobacco use; radiotherapy for head and neck cancer more than once.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-4ccv6f	Repercussions of electrostimulation in women with breast cancer during chemotherapy	Not yet recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1951	Repercussions of Transcutaneous Nervous Electric Stimulation applied to PC6 acupuncture point in women with breast cancer during chemotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-31	universidade federal de santa maria	universidade federal de santa maria	https://ensaiosclinicos.gov.br/rg/RBR-4ccv6f	<NULL>	Women with indications of chemotherapy neoadjuvant or adjuvant, of high and moderate emetogenic potential; age between 35 and 75 years	Central nervous system metastasis;second chemotherapy treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-3n8n8b	The effect of Group Physiotherapy on quality of life, improvement of pain and shoulder movements and emotional conditions of patients with shoulder pain	Not yet recruiting	Intervention	2018-07-04	<NULL>	<NULL>	1955	The Effect of Group Physiotherapeutic Intervention on the quality of life, functionality and psychic condition of patients with Shoulder Impact Syndrome	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Estadual Paulista	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3n8n8b	<NULL>	Diagnostic confirmation by clinical examination or image examination; Neer positive test; Hawkins test positive; pain during resistive isometric abduction; pain during passive or isometric lateral rotation resisted; pain during active shoulder lift; pain in the palpation of the rotator cuff tendons and pain in the region of the C5 and C6 dermatome.	Bilateral pain; age less than 40 years; pregnancy; systemic pathologies; physical therapy less than 3 months before the evaluation; signs of total rupture or acute inflammation of the rotator cuff; cervical spine-related symptoms; instability of the glenohumeral joint and history of fracture or surgery in the affected limb.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8hc3zf	A clinical study to evaluate the safety and blood concentration of Melatonin sublingual in healthy male research participants	Not yet recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1960	A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of Melatonin Sublingual Suspension, after a single dose in healthy male participants	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2018-09-10	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-8hc3zf	<NULL>	Healthy research participants; male gender; age equal to 18 and less than or equal to 35 years; body weight greater than or equal to 50Kg and BMI less than or equal to 30Kg/m2.	Research participants with complementary examinations outside normal values; history of excessive alcohol consumption; history of psychotropic drug use; have participated in any experimental drug study within 1 year before starting the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-46gj9d	Evaluation of mass loss and muscular strength in hospitalized elderly	Not yet recruiting	Observational	2018-07-05	<NULL>	<NULL>	1967	Evaluation of Sarcopenia in hospitalized elderly	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Estadual de Ponta Grossa	Hospital Universitário Regional dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-46gj9d	<NULL>	Elderly people from 60 years of age; hospital admission of up to 48 hours; hospitalization time equal to or greater than 5 days; previous functional independence report	Seniors who can not carry out the proposed evaluations; which have: peripheral saturation less than 85%, heart rate less than 50 or greater than 140bpm before evaluation; respiratory rate greater than 35 ipm, temperature greater than 38 ° C and blood pressure variation in 20% of the current (for more or less)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-8wrtq9	The benefits of exergames in the variables related to health	Not yet recruiting	Intervention	2018-07-09	<NULL>	<NULL>	1975	Effects of physical training with exergames in physiological and psychobiological variables health related	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Educação Física e Danca - Universidade Federal de Goiás	Faculdade de Educação Física e Danca - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8wrtq9	<NULL>	Age between 18 and 30 years.not involved in strength training programs.body mass index (BMI) of less than or equal to 25.0 kg / m².	Contraindication for performing physical activity assessed by the physical activity readiness questionnaire (PAR-Q).illiterate. regular use of alcoholic beverages and tobacco. orthopedic, metabolic, respiratory and/or neurological diseases and/or limitations that prevent physical activity.absence in more than 15% of the sessions.disease that has repercussions on mood disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-4vtsxb	Influence of genetic risk APOE on cognitive processing of elderly with Alzheimer&apos;s disease and healthy elderly	Not yet recruiting	Observational	2018-07-10	<NULL>	<NULL>	1985	Influence os Apoe genotype on event related potentials (ERP-P300) of elderly Alzheimer&apos;s disease and healthy elderly	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4vtsxb	<NULL>	"Healthy elderly: present preserved cognition as evaluated by the Mini-Mental State Examination. No diagnosis of depression or clinically relevant depressive symptoms assessed through the Geriatric Depression Scale (GDS-30). Elderly people without cognitive impairment and who are able to perform ERP-P300 evaluation. Not have reported any neuropsychiatric disease.
Elderly with Alzheimer&apos;s disease: Clinical diagnosis of AD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). Stages between mild and moderate according to the Clinical Dementia Rating (CDR). Elderly who are able to perform ERP-P300 evaluation. Not have reported other neuropsychiatric disease."	Advanced stage of Alzheimer&apos;s disease. Do not permormed ERP-P300.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-92qgnb	Comparison between two types of implants in patients with a history of aggressive periodontitis	Not yet recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1989	Comparison between two implant surfaces in patients with a history of aggressive periodontitis: randomized, controlled clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92qgnb	<NULL>	Older than 21 years; Need for rehabilitation of at least two dental elements with two dental implants, located in the same arch; Systemically healthy, without contraindications to oral surgical procedures; Proper oral hygiene (bleeding on probing less than 20%; plaque index less than 20%); Aggressive Periodontitis already treated; Signature of the free and informed consent form.	Pregnancy or lactation; Existence of metabolic bone disease; Use of drugs that influence bone metabolism; Use of bisphosphonates in the last 4 years; History of malignant tumor, radiotherapy or chemotherapy in the last 5 years; Smokers (greater than 20 cigarettes/day).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-4bhr78	Effect of clinical reasoning prompts for nursing students	Not yet recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2017	Effect of clinical reasoning prompts on the diagnostic accuracy of baccalaureate nursing students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Escola Paulista de Enfermagem	Departamento de Enfermagem da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4bhr78	<NULL>	Be a student of the baccalaureate course in Nursing; Have completed and have been approved in the subjects of Fundamentals of Nursing Care, Clinical Nursing and Surgical Nursing of EPE / UNIFESP; or have completed the disciplines of Fundamentals of Nursing Care and Nursing in Adult Health and the Elderly of UFPR.	Medical diagnosis of dyslexia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-86hhb7	The effect of Hand Therapy on quality of life, improvement of pain, function and psychic conditions of patients with shoulder pain	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2021	The effect of Manual therapy on the quality of life, funcionality and psychic condition of patientes with Shoulder Impact Syndrome	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Universidade Estadual Paulista Júlio de Mesquita Filho - Campus Botucatu	Centro de Fisioterapia e Saúde	https://ensaiosclinicos.gov.br/rg/RBR-86hhb7	<NULL>	Diagnostic confirmation by clinical examination or image examination; Neer positive test; Hawkins test positive; pain during resistive isometric abduction; pain during passive or isometric lateral rotation resisted; pain during active shoulder lift; pain in the palpation of the rotator cuff tendons and pain in the region of the C5 and C6 dermatome	Age less than 40 years; bilateral pain; pregnancy; systemic pathologies; physiotherapy for less than 6 months prior to assessment; signs of total rupture or acute inflammation of the rotator cuff; cervical spine related symptoms; glenohumeral joint instability; fracture history or surgery on the affected limb and adhesive capsulitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7zdk7k	Functional and pain evaluation of people with Haemophilia	Not yet recruiting	Observational	2018-07-18	<NULL>	<NULL>	2023	Algofunctional evaluation of people with Haemophilia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7zdk7k	<NULL>	Diagnosis of moderate or severe A or B haemophilia;individuals aged between 18 and 60 years of age;subjects in follow-up with the multidisciplinary team at the Haemophilia Orthopedics outpatient clinic at CHC-UFPR; individuals who have had the infusion of clotting factor VIII or IX immediately prior to the evaluation;be able to understand verbal command and carry out the proposed evaluations;being prophylaxis with coagulation factor VIII or IX between 2-3 times per week as prescribed by the hematologist;individuals who agreed to participate in the study by signing the free and informed consent form.	"Diagnosis of others coagulopathies; not within the age range specified above; patients who have undergone an orthopedic surgical procedure for arthroplasty; who do not perform prophylaxis with factor VIII or IX between 2-3 times a week;
that they did not infuse the factor immediately before the evaluation; individuals unable to realize and understand the proposed evaluations"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7xk5nr	Adherence to Drug Treatment in Patients with Chronic Pain: A Clinical Trial on the Use of Tablet Organizing Box	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2026	Drug Adherence of Patients with Chronic Pain: a Clinical Trial on the Use of Pill Box	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Departamento de Anestesiologia	"Universidade Estadual Paulista ""Julio de Mesquita Filho"" Faculdade de Medicina de Botucatu"	https://ensaiosclinicos.gov.br/rg/RBR-7xk5nr	<NULL>	Patients 18 years of age or older; with diagnosis of chronic pain; by the HCFMB-Unesp Pain Outpatient Clinic for a period of less than 1 year in an uninterrupted manner; be in use of at least two types of analgesic medication like opioids, anticonvulsants, common analgesics and antidepressants, in a maximum of four times a day; residing in the city of Botucatu and region; and be responsible for the administration and organization of analgesic medications	Patients with low cognitive capacity and illiterate; patients with cancer pain or fibromyalgia; history of non-adherence to other treatments; during the study, of dose adjustments and prescription of other medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-5ncdxh	Effect of patient positioning on Nephrolithotripsy results in the treatment of Complex Renal Calculations	Not yet recruiting	Intervention	2018-07-19	<NULL>	<NULL>	2028	Impact of Patient Position on the outcomes of Percutaneous Nephrolithothomy for Complex Kdney Stones	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Hospital de Transplantes Euryclides de Jesus Zerbini	Hospital de Transplantes Euryclides de Jesus Zerbini	https://ensaiosclinicos.gov.br/rg/RBR-5ncdxh	<NULL>	Complex Kidney Stones; Classification Guys 3 or 4; Indication of percutaneous surgery	Contraindication for percutaneous nephrolithotripsy; Ipsilateral or contralateral ureteral calculus; Bladder calculus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-7hfwzj	Dressings, nutritional supplementation and teaching of the patient and caregiver for the healing of bedsores	Not yet recruiting	Intervention	2018-07-19	<NULL>	<NULL>	2029	Effect of combined technology in the treatment of pressure injuries: contribution for clinic care management	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Goiás	Centro Estadual de Reabilitação e Readaptação Dr Henrique Santillo	https://ensaiosclinicos.gov.br/rg/RBR-7hfwzj	<NULL>	"Patients 18 years of age or over; pressure injury in stages 2, 3 or 4 up until 24 cm2; body mass index equal or greater than 18,5 kg/m2 and lower than 30 kg/m2 and therapeutic plan of hospitalization in the institution for at least 30 days; scoring on the mini-test of mental state equal or greater the expected scoring for the scholarity

Caregivers 18 years of age or older; scoring on the mini-test of mental state equal or greater the expected scoring for the scholarity"	"Patients with a previous history of allergy to any plant from the Asteraceae or Pedaliaceae family; renal or liver diseases; osteomyelitis; cellulitis; systemic use of corticoids; immunosuppressants, radiation, chemotherapy less than four weeks before entering this study and myiasis

Caregivers with visual deficit that blocks visualization of the educational material for the care; hearing deficiency moderate to severe that blocks orientation comprehension"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-5g4n3p	Evaluation of zika test for yellow fever vaccineted.	Not yet recruiting	Observational	2018-07-23	<NULL>	<NULL>	2043	Performance Evaluation  of the Rapid Test for Serological Diagnosis of Zika (TR DPP IgM / IgG Zika - Bio-Manguinhos) in a Cohort of Yellow Fever Vaccines	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-01-29	Instituto de Tecnologia em Imunobiológicos de BioManguinhos/Fundação Oswaldo Cruz (Fiocruz)	Ministério da ciência, tecnologia, inovações e comunicações - CNpq	https://ensaiosclinicos.gov.br/rg/RBR-5g4n3p	<NULL>	Adult participant or the person legally responsible be able to understanding and signing the TCLE. If the participant or the person legally responsible in charge is not able to sign, the TCLE can be signed by an impartial witness who has been following the whole procedure; Acceptance of participation in the study, after reading and understanding of the Informed Consent Form (TCLE) and signature of the same; Participants of both genders aged from 9 months to 4 years 11 months and 29 days, since they are not received or received by Viral Triple Vaccine or Viral Tetra within an interval of 30 days or less; Healthy adults of both genders aged 18-50 years since they are not received or received by MMR or MMR within 30 days or less; Permanent residence in the municipality where a Basic Health Unit is located, where a vaccination and collection of biological material (blood) is carried out for the study, at the time of inclusion in the study; Never have resided or stayed temporarily in an area with a yellow fever vaccination recommendation; Do not travel to areas with vaccination recommendation against yellow fever; Availability for follow-up activities throughout the study period; Agree on provide the name, address, telephone and other personal information, if applicable, if necessary (for example, in the case of a missed visit scheduled for follow-up); Availability to follow the study protocol; Acceptance for serological testing for HIV; In adult women of childbearing age, a pregnancy test (TIG); Have a good health with no significant medical history (as described in the exclusion criteria); Physical examination of significant clinical clinical trials.	Previous vaccination for yellow fever; Presumed or confirmed pregnancy, at any stage; Women who are breastfeeding; People in current or recent use of immunosuppressive drugs; People with a personal history of anaphylactic reaction to food, medicine, or vaccines; People with a personal history of egg, erythromycin, kanamycin, or gelatin allergies; People with autoimmune diseases; HIV-seropositive individuals; People with a history of thymus diseases, such as thymoma, myasthenia gravis and thymectomy due to thymoma; Persons who have received immunoglobulin, blood transfusions or derivatives in the last 60 days; Persons who have received live virus or cholera vaccines within the past 30 days or who plan to receive them within 30 days after vaccination for yellow fever; People with acute febrile illness, with compromised general health; Persons who have presented rash within the past 30 days; Persons immunocompromised by disease (eg neoplasms, AIDS, HIV infection with impaired immunity etc.) or by drugs (immunosuppressive drugs, radiation therapy etc.).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-65nfhn	Evaluation of program in oral health education in children and adolescents with chronic kidney disease	Not yet recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2048	Humanoid robots - Evaluation of artificial intelligence in oral health education in children and adolescents with chronic kidney disease: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Faculdade de odontologia da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-65nfhn	<NULL>	Children and adolescents aged 6 -18 years; cooperators in relation to the initial clinical examination and understanding of the questions and orientations presented; with possibility of follow-up for 1 month.	Children who presented an acute systemic picture in the last 30 days; children who are feeding via catheter, with cognitive and / or motor deficiency and with orthodontic appliance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-2w9bhc	Nutritional intervention in overweight pregnant women attending primary healthcare units	Not yet recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2066	Nutritional intervention study in overweight pregnant women attending primary healthcare units: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Centro de Saúde Escola - Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2w9bhc	<NULL>	Age over 18 years old; gestational age at the time of screening up to the 15th weeks and 6 days; and BMI at the time of screening between 25 and 29.9 kg per square meter	Twin pregnancy; previous diabetes; in use of weight loss medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-5nx7fk	Regression evaluation of swelling in the face after orthognathic surgery with and without the use of functional elastic bandage in patients with cleft lip and palate	Not yet recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2068	Regression evaluation of facial edema after orthognathic surgery with and without the use of Kinesio Taping in patients with cleft lip and palate: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-17	Hospital de Reabilitação de Anomalias Craniofaciais HRAC/USP	Hospital de Reabilitação de Anomalias Craniofaciais HRAC/USP	https://ensaiosclinicos.gov.br/rg/RBR-5nx7fk	<NULL>	"Agree to the free and informed consent term;
Agree to remain in the hospital the time necessary for the data collection;
Presence of cleft lip and palate repaired;
Both sexes aged between 18 and 40 years;
Indication for bimaxilar orthognathic surgery"	"Present hypersensitivity to Kinesio Taping tape;
To present facial lymphedema grade III and IV;
To present peripheral facial neuralgias;
To present moderate or severe hematoma in the postoperative period;
Have severe intra- or postoperative bleeding"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3st5sn	Test of a strategy for childhood obesity based on the Food Guide for the Brazilian Population	Not yet recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2072	Effectiveness of a strategy for the treatment of childhood obesity based on the Food Guide for the Brazilian Population: a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-3st5sn	<NULL>	Be between 7 and 10 years old. Be obese.	Possessing pre-existing genetic disorders associated with obesity such as congenital leptin deficiency, Down syndrome, Prader-Willi syndrome) or endocrine disorder (hypothyroidism, Cushing&apos;s syndrome). Children and adolescents with some deficiency that prevents the accomplishment of anthropometric measurements. Patients undergoing nutritional monitoring and using medications for weight loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-74zbms	Electrostimulation physiotherapy influence on the sexual function of women with precocious menopause: controlled randomized clinical study	Not yet recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2074	Interferential Current influence on the sexual function of women with Premature Ovarian Failure: controlled randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-74zbms	<NULL>	Women with Premature ovarian Insufficiency for one year or more;  in use of systemic hormone therapy three months or more; Age between 18 and 50 years, sexually active; Presenting sexual activity for at least six months with at least one intercourse in the last four weeks	"Women with complaints of sexual dysfunction exclusively related to the absence of desire; Use of copper IUDs, pacemakers, or some type of metal implant in the lumbar spine or hip region; Women with an acute infectious process in the vulvar region, genital ulcer or using medications that may cause mucositis; Women undergoing systemic or acute localizes allergic conditions;
Women who are known to have a chronic degenerative disease, chronic immunosuppression, pelvic or spine deformity, neoplastic diseases; Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-26gmvg	Benefits of Epidural block in pain control after liver embolization, compared to venous analgesia	Not yet recruiting	Intervention	2018-08-01	<NULL>	<NULL>	2081	Randomized clinical trial on the effectiveness and benefits of Peridural blocking in the control of Post-embolization syndrome, compared to venous analgesia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Fundação Antônio Prudente	Fundação Antônio Prudente	https://ensaiosclinicos.gov.br/rg/RBR-26gmvg	<NULL>	Patients of both genders; 18 years or more; submitted to hepatic embolization; consent to the free and informed consent form.	"Absolute contraindications and related to epidural block; patients who remain intubated or are reintubated in the postoperative period; present epidural block failure;
with dialysis renal insufficiency or severe hepatic impairment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-8xtc9c	Use of a smartphone app combined with streaming content and game elements to increase the level of physical activity of adults and older adults	Not yet recruiting	Intervention	2018-08-03	<NULL>	<NULL>	2088	Use of a smartphone app combined with beacons and gamification to increase the level of physical activity of adults and older adults: a sequential multiple assignment randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Universidade Federal de São Paulo	Laboratório de Epidemiologia e Movimento Humano - EPIMOV	https://ensaiosclinicos.gov.br/rg/RBR-8xtc9c	<NULL>	Age over 20 years old, without diagnosed cardiorespiratory diseases, musculoskeletal limitations, electrocardiographic abnormalities, or other conditions that preclude the safe practice of physical activity, has to own a smartphone and be familiar with the use of the device.	Basal average level of physical activity &gt;= 10,000 steps per use of walking aids, recent respiratory infections, spirometric abnormalities, stable or unstable angina on the 4 weeks prior to evaluation,  recent myocardial infarction, history of angioplasty or heart surgery, bradycardia or tachycardia, and refuse to participate by signing the informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-78tr7x	Effectiveness of technology for nursing care	Not yet recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2093	Multimedia application to support the systematization of nursing care to the clinical patient	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade de Fortaleza	Laboratório de Tecnologia em Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-78tr7x	<NULL>	Students regularly enrolled in the year 2018; being in the discipline of caring 3 (Semiology)	Students who have previous experiences with anamnesis and physical examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-6yj8sj	Vitamin D action in the treatment of Depression and reduction of Cardiovascular Risk	Not yet recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2095	Vitamin D Action in Depression and Cardiovascular Risk in Outpatient Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6yj8sj	<NULL>	"Adults in the age group of 18 to 59 years;
Both sexes;
People with depression;
Attended in psychiatric outpatient clinics;
In treatment with antidepressants"	Exclusion Criteria: patients who are already being supplemented with vitamin D, with a personal history of psychiatric comorbidities, chronic kidney disease, hypercalcemia, neoplasias and pregnant women or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7qnffg	The effect of muscle strengthening of the calf on the walking of children with toe walking.	Not yet recruiting	Intervention	2018-01-29	<NULL>	<NULL>	2116	The effects of muscle strengthening of the plantar flexors on the gait pattern of children with idiopathic toe walking.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade Federal de São Paulo	Instituto de Assistência ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qnffg	<NULL>	The inclusion criteria will be: children between 5 and 11 years of age; of both sexes; diagnosed with idiopathic toe walking; that present gait in equine; with bilateral involvement and that do not present any neurological or psychiatric impairment.	The exclusion criteria will be: children under 5 years and over 11 years of age; with structural ankle deformity in equine (inability to reach the ankle neutral position passively); with central or peripheral neurological impairment; who are unable to minimally understand the questions used during the evaluations; which have undergone surgery in the lower limbs or who have undergone the application of botulinum toxin in the last 12 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-5q5dg8	Oral Polypodium Leucotomos and Ingenol Mebutate  gel 0.05% or Colchicine cream 0.5% in the treatment of Solar Queratoses	Not yet recruiting	Intervention	2018-08-15	<NULL>	<NULL>	2122	Oral Polypodium leucotomos versus placebo associated to Ingenol Mebutate 0.05% gel or Colchicin 0.5% cream in treatment of Actinic Keratoses and Skin Field Cancerization: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Faculdade de Medicina - Unesp Botucatu	Faculdade de Medicina - Unesp Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-5q5dg8	<NULL>	"Sign the Term of Free and Informed Consent;
• Age above 18 years of both sexes;
• Present at least three and at most ten lesions clinically compatible with actinic keratosis in each forearm, bilaterally."	"Injuries less than three or greater than ten in each forearm;
Selected treatment area that has atypical clinical appearance or other extensive dermatoses on the forearms;
Current and prior clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment;
To show hypersensitivity or allergy to any of the studied sub-substances;
Patients on any systemic or topical immunosuppressive substance, oral retinoid, in addition to other local treatments (eg corticosteroids, anti-inflammatories, retinoids);
Immunocompromised individuals;
Coagulation disorders;
Suspected or confirmed pregnancy;
Women of childbearing potential who do not use contraceptive methods;
Women in the breastfeeding phase."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-6pcrfm	Light strength exercise associated with Partial Occlusion of blood in the treatment of knee osteoarthritis	Not yet recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2128	Very low load and low volume exercise associated with Partial Vascular Occlusion in the knee osteoarthritis treatment: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-31	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6pcrfm	<NULL>	Are 50 years of age or more; Have a body mass index (BMI) of up to 35 kgm-2; Have moderate to very severe knee osteoarthritis (score between 5 and 13 on the Lequesne Questionnaire); Have score of 24 or more on Mini-Mental State Examination; Do not have peripheral vascular disease, systolic blood pressure greater than 160 or smaller than 100mmHg, diastolic blood pressure greater than 100mmHg, deep vein thrombosis, history of myocardial infarction, stroke in the last year or history of cancer; Do not have other orthopedic problems that affect gait and do not present other inflammatory myoarticular or neurological diseases; Have not undergone surgery or any invasive procedure for the knees in the last 6 months; Not participating in physiotherapeutic treatment or lower limb strengthening programs in the past three months; Not practicing regular physical activity (two or more times per week) for lower limbs (except for those who only practice walking).	Experience pain that prevents completely the exercises proposed by two consecutive sessions or three non-consecutive or who refuse to remain in the study; Begin taking medications that interfere with study outcomes or begin to exercise or other treatment modalities for knee OA after the initiation of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-59g3wf	Anesthetic properties of two solutions used in the injection technique with less dense bone and greater penetration with the use of electronic injector	Not yet recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2131	Anesthetic properties of two solutions in the Alveolar Crest Technique Spongeous Bone Zone using injector	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-59g3wf	<NULL>	Be between 18 and 35 years of age; Patients of both sexes; Patients who were not submitted to blockade anesthesia in the region in the two weeks prior to the study; Do not use any medication of action of the central nervous system; ASA I and II patients with no history of hypersensitivity to the drugs under study; Present units 36 and 46 in need of restorative treatment;	Pregnant women; History of psychiatric illness that may compromise the ability to provide informed consent; History of drug dependence or abusive alcohol consumption; Odontophobic; Patient ASA III and IV	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-3zs6g9	Effects of equine therapy on postural balance, gait, performance and functional mobility and quality of life in healthy people and people with disability	Not yet recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2149	Evaluation of the stimuli produced by the intervention with equine therapy on the kinetic and kinematic variables of healthy and pathological subjects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-12	Universidade de Brasilia	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3zs6g9	<NULL>	"The volunteers should be have more than 6 months after stroke; have a level 3 or higher in the
Functional Ambulation Category (FAC) -
walk independently or with the help of a third party; have a score higher than
24 in the Mental State Mini Exam or appropriate score in case of
illiterates.
For subjects with multiple sclerosis: The inclusion criteria adopted were: women aged between 20 and 60 years; confirmed medical diagnosis of multiple sclerosis in its most frequent form (referent-recurrent); rated between 1.0 and 3.0 by the EDSS scale."	"Diagnosis of Bilateral Stroke with double hemiparesis; uncorrected visual or auditory deficiency;
comorbidities that may interfere with the equotherapeutic treatment, for example,
psychiatric problems, cognitive deficit with apraxia, aphasia with inability to
follow simple commands; patients with active cardiovascular diseases;
uncontrolled diabetes and weight greater than 97 kg; have practiced activity
in the last 6 months;
For subjects with multiple sclerosis:The exclusion criteria were: having had an outbreak in the last 30 days; presence of infectious and neoplastic diseases; have musculoskeletal disease in the lower limbs that compromises the performance of the tests; associated neurological diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-5t8dbp	Effect of Physical Training in Treadmills on stiffness of arteries of Diabetic patients	Not yet recruiting	Intervention	2018-08-27	<NULL>	<NULL>	2153	Effect of Aerobic Training based on maximal fat oxidation on arterial stiffness in subjects diagnosed with Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Programa de Pós-Graduação em Fisioterapia - PPGFt	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5t8dbp	<NULL>	Individuals diagnosed with type 2 diabetes of both sexes; from 40 to 60 years of age; who do not exercise vigorously at maximal and frequency greater than or equal to three times a week and who agree to participate in the study and sign the term of free and informed consent.	Individuals with a history of clinically proven cardiopathy or examination; uncontrolled arterial hypertension; musculoskeletal or respiratory disorders; cognitive disturbances that prevent the understanding of the experimental procedure; pregnant women; smokers; alcoholics or users of non-licit drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-77kfj5	Evaluation of the interference in the immunity caused by anesthetics Sevoflurane versus Propofol in intraoperative obese patients (obesita): study protocol for a randomized clinical trial	Not yet recruiting	Intervention	2018-08-30	<NULL>	<NULL>	2159	Evaluation of the immunomodulatory response of Sevoflurane versus Propofol in the intraoperative of obese patients (obesita): study protocol for a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-11	Rede D&apos;Or Sao Luiz S.A.	Laboratório de Investigação Pulmonar da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-77kfj5	<NULL>	Age range 18 to 59 years; body mass index greater than or equal to 35 kilograms per square meter; signature of the free and informed consent form.	Patients with insulin; anti-inflammatory and / or immunosuppressive therapies; diagnosis of malignant disease; chronic kidney disease, with KDOQI greater than 3; chronic liver disease, with total serum protein less than 3 grams per deciliter and total bilirubin greater than 5 milligrams per deciliter; heart disease, with NYHA III or IV; obesity caused by endocrine disorder; patients with psychiatric illness that may interfere with the capacity for formal consent and compliance; persistent smoking associated with significant obstructive or restrictive lung disease, with vital capacity or forced expiratory volume in one second less than 50% of predicted value; alcohol dependence; pre-existing coagulation disorders; evident pulmonary or systemic infection, with clinically defined or increased C reactive protein above 5 milligrams per ml, leukocytosis greater than 10,000, or body temperature greater than 37 Celsius; presence of autoimmune diseases; participated in another randomized clinical trial in the last year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-4rj39m	Rheumatoid Arthritis patients groups	Not yet recruiting	Intervention	2018-08-31	<NULL>	<NULL>	2163	Educational groups for patients with Rheumatoid Arthritis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-31	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4rj39m	<NULL>	Rheumatoid Arthritis diagnosis; Management of Rheumatoid Arthritis in Rheumatology Department of Clinics Hospital of Federal University of Minas Gerais; Avaiability to attend reunions of the patient&apos;s groups; Giving informed consent (by signing the consent form).	Refusal to participate of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-4y4q7z	Training through kinesiotherapy and pilates to the pelvic floor	Not yet recruiting	Intervention	2018-09-03	<NULL>	<NULL>	2167	Pelvic floor training in the elderly: A randomized controlled trial comparing treatment techniques through the pilates method and kinesiotherapy.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Pontifícia Universidade católica do Rio Grande do Sul	Pontifícia Universidade católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4y4q7z	<NULL>	Women aged 60 or over, living in Porto Alegre and who agree to participate in the study and who have signed the Free and Informed Consent Term.	women with disabling diseases that prevent the performance of pilates exercises that have undergone gynecological surgery will be excluded, in order to initiate any type of structured and planned physical activity, in addition to those provided for in this protocol and that present genital prolapse above the second the POP-Q classification (Pelvic Organ Prolapse Quantification System).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-3bz2h2	Preventive intervention of changes in Body Image, Eating Disorder and Body Dysmorphism of young adult men	Not yet recruiting	Intervention	2018-09-04	<NULL>	<NULL>	2170	Preventive intervention in Body Image Disturbances, Eating Disorder and Body Dysmorphia in young adults: a randomized controlled clinical trial in Brazilian men	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Federal de Juiz de Fora campus avançado Governador Valadares	Universidade Federal de Juiz de Fora campus avançado Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-3bz2h2	<NULL>	Students. Men. Male. Between 18 and 30 years. Any color, race or ethnicity. Be regurlamente enrolled in the Federal University of Juiz de Fora-UFJF campus Governador Valadares - MG. Opt to participate voluntarily in the study.	Possess mental disorder, food and / or dysmorphic body diagnosed. Do not respond to instruments in the follow-up period. Ask for the termination of your participation, by means of an express, free and informed expression. Expressly request not to use your data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-7zccgr	Effects of complementary therapies associated with Cardiac Rehabilitation in patients with Chronic Heart Failure	Not yet recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2176	Effects of Noninvasive Ventilation and Inspiratory Muscle Training associated with Cardiac Rehabilitation in the kinetics of oxygen consumption in patients with Chronic Heart Failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-03	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte- UFRN	https://ensaiosclinicos.gov.br/rg/RBR-7zccgr	<NULL>	The patients present a diagnosis of stable chronic Heart failure who are undergoing medical follow-up with a cardiologist and present stable disease suggested by the absence of any change in medication and without previous diagnosis of moderate or severe chronic obstructive pulmonary disease, exercise-induced asthma and previous hospitalization history last 3 months and anginal events in the three months before the study, with left ventricular systolic dysfunction with LVEF &lt;40% and New York Heart Association (NYHA) classification in classes II and III.	Patients with musculoskeletal diseases or any other situation that makes it impossible to perform aerobic or resisted exercises. To present worsening of signs and symptoms of HF after starting the proposed rehabilitation program. Present paradoxical breathing or persistent use of accessory breathing muscles or oxygen desaturation during the exercise program. Body mass index (BMI) &lt;35 kg / m. Any individual with severe, significant arrhythmias or unable to perform the exercise protocol associated with Non- invasive ventilation (NIV) or Respiratory Muscle Training (RMT) will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-6t4j85	An evaluation of a medicinal herb as a treatment for Parkinson’s disease	Not yet recruiting	Intervention	2018-09-10	<NULL>	<NULL>	2184	A phase 2, double-blind, randomized, controlled trial of the safety and efficacy of Banisteriopsis caapi versus placebo in patients with Parkinson´s disease	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-09-02	Hospital Universitário Clementino Fraga Filho - UFRJ	Hospital Universitário Clementino Fraga Filho - UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-6t4j85	<NULL>	40 l-dopa treated patients (both genders) with Parkinson’s disease fulfilling the Queen Square Brain Bank Criteria with mild to moderate motor fluctuations will be recruited.	Demented patients with the Mini Mental Status Examination Score, women of childbearing age and those receiving monoamine oxidase inhibitors or amantidine were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-7rwmvj	Influence of mechanical ventilation and heart rate on obstruction to cardiac blood flow in patients with hypertrophic obstructive cardiomyopathy	Not yet recruiting	Intervention	2018-09-11	<NULL>	<NULL>	2187	Influence of PEEP and heart rate on the maximum systolic gradient of the left ventricular outflow tract of patients with hypertrophic obstructive cardiomyopathy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-04	Instituto Dante Pazzanese de Cardiologia	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-7rwmvj	<NULL>	All adult patients (&gt; 18 years) diagnosed with hypertrophic obstructive cardiomyopathy, in follow-up at the cardiology outpatient clinics of the Dante Pazzanese Institute of Cardiology, with indication of septal reduction therapy, submitted to endocardial radiofrequency ablation of septal hypertrophy, who agree to participate in the study.	Patients who did not agree to participate in the study; Age under 18 years; Chronic obstructive pulmonary disease; Previous surgical myomectomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-8mpyq4	Effects of interval running and cranberry supplementation on the immune system	Not yet recruiting	Intervention	2018-09-12	<NULL>	<NULL>	2193	Effects of interval training and cranberry supplementation in immunomodulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8mpyq4	<NULL>	Present VO2max classification between 35 and 55 ml.kg-1.min-1; be engaged in running training for at least three times a week; has no musculoskeletal disorder, autoimmune, cardiac, pulmonary or hypersensitivity disease; not use anti-inflammatory drugs or food supplements, including substances with antioxidant function, at least 30 days before the study period.	Do not meet 100% of the number of sprints in one or more high intensity interval training (HIIT) protocols; do not carry out any of the pre or post evaluation of HIIT; if they are absent in one of the six sessions of HIIT; present any injury or motor impairment to perform HIIT; present any infection of the upper respiratory tract during the experiment; antibiotic use within six months prior to study; regularly consume any dietary supplement composed of vitamins, minerals or bioactive compounds; do not consume any of the doses of cranberry proposed for the supplementation stage; present known allergy or intolerance to cranberry products.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2z96w6	Effects of Multicomponent Exercise on Cognition in the elderly	Not yet recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2195	Multicomponent exercise program on cognition, structure and brain function in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Federal do Rio Grande do Norte - UFRN	Hospital Universitário Onofre Lopes- HUOL/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-2z96w6	<NULL>	Age between 60 and 75 years, with medical clearance to six months before clinical evaluation.	Body mass index equal or greater to 35; use of medication that suppresses neuroendocrine system responses; not reach the minimum of 23 points in the mini mental state exam; musculoskeletal limitations that limits the practice of physical activity; report at least one yes on response in PARQ; participate in regular physical exercise programs and dietary interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-4sw7h7	Comparison of fat grafting techniques for reconstruction of head deformities after surgical treatment of epilepsy	Not yet recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2196	A comparative randomized clinical trial of different autologous free fat grafting techniques for reconstruction of temporal contour defects after surgical treatment of epilepsy: structural fat grafting versus micro autologous fat transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Faculdade de Ciências Médicas, UNICAMP	Hospital SOBRAPAR	https://ensaiosclinicos.gov.br/rg/RBR-4sw7h7	<NULL>	Patients over 18 years of age; both genders; ASA (American Society of Anesthesiology) 1 or 2; submitted to standardized craniotomy for the treatment of temporal lobe epilepsy for at least 12 months; with temporal contour deformity; integrity of the craniofacial skeleton	Patients undergoing additional cranial surgery; pregnancy; active infection in the temporal region; previous radiotherapy; contraindications for magnetic resonance imaging such as the presence of cardiac pacing, intracranial metal clips and / or severe claustrophobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-4gjhfk	Proximetacaine anesthetic effect in the eyes: comparison between eyedrops in open eyes and vaporization in closed eyes	Not yet recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2234	Anesthetic effect of Proximetacaine hydrochloride 0,5%: comparison between eyedrop instillation in open eyes and vaporization in closed eyes	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Estácio de Sá	Universidade Estácio de Sá	https://ensaiosclinicos.gov.br/rg/RBR-4gjhfk	<NULL>	Adult volunteers; both genders;  consulted at the Policlinica Ronaldo Gazolla ophthalmological clinic;  need to perform aplanation tonometry for intraocular pressure measurement.	volunteers with corneal disease; Refusal in signing the informed consent; Mentally retarded that does not understand research procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-2b6r7q	Aleatory clinical trial: evaluation of the effect of an application for mobile phones as an aid in the prevention of Bottle Caries	Not yet recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2237	Randomized clinical trial: evaluation of the effectiveness of an application for mobile phones as an aid in the prevention of early childhood caries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-30	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2b6r7q	<NULL>	"Children aged 36-60 months; both genders; 
with high risk of dental caries; Parents or guardians must have a smartphone with Internet access; Parents or guardians must have the WhattsApp application installed on their smartphone"	Children with caries lesions with ICDAS greater than or equal to 4; Parents or guardians who can not access WhattsApp frequently	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-5zb4dg	Lasertherapy and electrical stimulation on Lateral Epicondylitis: joint function and tendon repair.	Not yet recruiting	Intervention	2018-09-26	<NULL>	<NULL>	2239	Photobiomodulation and diadynamic currents on Lateral Epicondylitis: joint function and tissue repair	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal de São Paulo	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5zb4dg	<NULL>	Volunteers will be included if they meet the following criteria: age between 18 and 70 years; less than 6 months of epicondylalgia symptoms; absence of systemic diseases; pain at palpation over the lateral epicondyle region of the elbow or common tendon pathway of the extensor muscles; pain to the movement of wrist extension against resistance Visual Analog Scale (AVE) score of pain equal to or greater than 3 and diagnosis of lateral epicondylitis of the elbow.	Will be excluded from the study volunteers who present a history of fracture in the elbow joint; carriers of osteosynthesis metal material in the upper limb; patients with cardiac pacemakers; tactile sensory deficit in the upper limb; history of conservative or surgical treatment for epicondylalgia in the last 3 months; use of anti-inflammatory medication during the experiment and volunteers who underwent corticosteroid injection in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-59j8xf	Evaluation and comparison of different methodologies for the diagnosis of schistosomiasis.	Not yet recruiting	Intervention	2018-09-27	<NULL>	<NULL>	2246	Evaluation of new diagnostic methodologies for schistosomiasis mansoni in the current epidemiological scenario.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-18	centro de Pesquisas René Rachou	centro de Pesquisas René Rachou	https://ensaiosclinicos.gov.br/rg/RBR-59j8xf	<NULL>	Residents of the Santa Rita Neighborhood; both genders; over 6 years and less than 105 years.	Have received treatment for Schistosoma mansoni infection in less than 12 months from the date of collection of the biological samples; do not deliver or allow collection of biological samples.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-57qgrj	Brief Intervention for elderly Alcoholic Beverages users	Not yet recruiting	Intervention	2018-09-28	<NULL>	<NULL>	2250	Brief Intervention for elderly Alcohol users	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Escola de Enfermagem de Ribeirão Preto - USP	Escola de Enfermagem de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-57qgrj	<NULL>	Participants will be eligible to screen those age 60 or older and have had contact with alcohol at least once in their lifetime.	The criterion of exclusion adopted will be to show visible difficulty in understanding and expressing oneself; being hospitalized due to some clinical complication; be sick and bedridden or have changed addresses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6b8rvt	Effects of Green Tea Supplementation after Fatty Meal in obese patients on change in blood inflammation	Not yet recruiting	Intervention	2018-10-01	<NULL>	<NULL>	2253	Effects of acute green tea supplementation, after the ingestion of a hyperlipidic diet, in obese individuals, in  oxidative stress,  inflammatory process and in the expression of miRNAs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Faculdade de Medicina de Botucatu- Unesp	Faculdade de Medicina de Botucatu- Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6b8rvt	<NULL>	age greater than or equal to eighteen years and obesity (BMI greater than or equal to thirty kilograms per square meter).	Use of dietary supplements and systemic corticosteroids in the last three months, diagnosis of chronic non transmissible  diseases such as hypertension, diabetes mellitus II, dyslipidemia, thyroid disease, neoplasms, coronary artery disease, stroke, heart failure, renal or hepatic failure and allergy to food offered in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6h8kp2	Pharmacoeconomic study of stomach reduction surgery	Not yet recruiting	Intervention	2018-10-04	<NULL>	<NULL>	2261	Cohort study of follow-up of participants submitted to Conventional Open Bariatric Surgery versus Laparoscopic Surgery. Clinical and pharmacoeconomic evaluation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Hospital e Maternidade São Luiz	Hospital São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-6h8kp2	<NULL>	Sign the TCLE approved by the CEP; Men and women, older than 18 years; To present a BMI greater than or equal to 35 kg / m2 associated with comorbidities or to have a BMI greater than 40 kg / m2; Clinical intractability of obesity observed by endocrinologist; Established indication for indication of bariatric surgery according to the Brazilian Society of Bariatric and Metabolic Surgery (SBCBM) and Resolution 2.131 of 2015 of the Federal Council of Medicine (CFM).	Anesthesia risk classified as ASA IV; Portal hypertension with esophagogastric varices; Significant intellectual limitation; Current uncontrolled psychiatric disorder; Regular users of alcohol or illicit drugs; Any other prior disease that in the opinion of the investigator contraindicates participation in the study; Women of childbearing age without adequate contraception or infants; Participation in another clinical study in less than 1 year (unless justified by the investigator);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-7k576j	Double treatment with Glycopyrronium and Indacaterol versus single treatment with Glycopyrronium in treatment of lung disease	Not yet recruiting	Intervention	2018-10-04	<NULL>	<NULL>	2262	Dual therapy with Glycopyrronium and Indacaterol versus monotherapy with Glycopyrronium in treatment of Copd patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-10-12	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7k576j	<NULL>	Patients (men and women) with COPD confirmed by spirometry. The diagnosis of the disease will be made by performing spirometry that will confirm the obstruction to the airflow through the result of the relation between forced expiratory volume in the first second (FEV1) and forced vital capacity of less than seventy per cent after use of inhaled bronchodilator. The patient must have stable disease. No need for hospitalization in the thirty days prior to the evaluation. Preserved neurocognitive functions. Be an adult and agree to participate in the study.	Patients with respiratory tract infection or who have been hospitalized for an exacerbation in the last month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-6wdrhw	Study of Pegfilgrastim similar in Healthy Participants.	Not yet recruiting	Intervention	2018-10-05	<NULL>	<NULL>	2266	Phase I Clinical Study with Pharmacokinetic and Pharmacodynamic Determination of Pegfilgrastim for Subcutaneous Use in Healthy Participants.	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-01-15	CAEP - Centro Avançado de Estudos e Pesquisas	Inovatie Consultoria e Serviços em Saúde Ltda - ME	https://ensaiosclinicos.gov.br/rg/RBR-6wdrhw	<NULL>	Sign the TCLE approved by the CEP; Participants of both sexes between the ages of 18 and 55; Participant must be physically and mentally healthy through information collected from medical history, general physical examination and vital signs, laboratory tests and electrocardiogram not indicating any evidence of disease; Body mass index (BMI) greater than or equal to 18.5 and less than or equal to 29.9 kg / m2.	Diagnosis of malignant disease in the last 5 years, except for successful basal cell carcinoma; Prior diagnosis of severe asthma, sickle-cell anemia or anaphylaxis; Laboratory alteration (at the discretion of the researcher) of any nature that could compromise participation in the study; Use of legal or illegal drugs; Hypersensitivity or contraindication of use to the components of the medications studied; Participation in another clinical study in a period of less than 1 year (unless justified by the researcher); Women of childbearing age without adequate contraception, pregnant or breastfeeding; Blood donation (greater than 500 mL) in the preceding 3 (three) months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-4fgh4z	Analysis of the effects of a program of physical exercise using the legs in the motor function of the arms in patients who have stroke	Not yet recruiting	Intervention	2018-10-10	<NULL>	<NULL>	2274	Analysis of the effects of an aerobic exercise program using lower member in the motor function of the upper limb in chronic patients after Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-30	faculdade de medicina de ribeirão preto	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fgh4z	<NULL>	Participants should have had an episode of ischemic stroke for at least 6 months, be between 18 and 80 years old, absence of joint blockages in the upper and lower limbs, ability to walk for 6 minutes independently and get on mini-examination of mental status score according to level of schooling.	Symptomatic cardiac arrhythmia (atrial fibrillation in anticoagulation), uncontrolled arterial hypertension (at the examiner&apos;s discretion), decompensated heart failure (functional class 2, 3 or 4), severe respiratory disorders (chronic obstructive pulmonary disease, pneumonia ), impossibility of attending the appointments and non-signing of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-4jmz36	Can a dental care intervention reduce the risk of death of patients treated in intensive care units? A clinical randomized study	Not yet recruiting	Intervention	2018-07-10	<NULL>	<NULL>	2276	Can a dental care intervention reduce the risk of death among critical patients? A cluster randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-02	Departamento de Medicina Social da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4jmz36	<NULL>	The intention to treat study population will consist of any patient with ages between 18 to 100 years old admitted for ICU admission during the study period. Subsequently, in the data analysis, those who remain hospitalized for at least 72 hours and have received at least two dental treatment sessions will be considered a per protocol subpopulation.	Patients who cross the washout period, ie remain in the ICU after the interval of 1 month between the alternation of intervention to control conglomerates and vice-versa, will be excluded from the study. This exclusion will only be from the database for analysis. This does not imply the interruption of dental care if the patient needs it.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-43wzk4	Laser and the Pilates Method for Non-Specific Chronic Lower Back Pain	Not yet recruiting	Intervention	2018-10-11	<NULL>	<NULL>	2279	Effects of Laser and the Pilates Method on Non-specific Chronic Low Back Pain: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-12-08	Unidade de Ensino Superior do Sul do Maranhão	Universidade do Vale do Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-43wzk4	<NULL>	Patients with clinical diagnosis of chronic non-specific low back pain; Age greater than 18 years and less than 40 years; Both sexes; That they do not present another pathology in the vertebral column.	"Carriers of systemic diseases; that they are performing another type of treatment; individuals with neurological disorders; with diagnosis of; vascular disease and metabolic disease; with the presence of neoplasias;
That they are in effect of any anti-inflammatory or analgesic drug by prescription or self-medication; individuals who score on the Visual Analogue Scale less than 2;and those that do not fit the inclusion criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-89wcdn	Partial Removal of Caries in permanent teeth	Not yet recruiting	Intervention	2018-10-18	<NULL>	<NULL>	2290	Clinical controlled trial of the Partial Removal of Carious Dentin in permanent teeth with shallow, medium and deep Caries lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-89wcdn	<NULL>	Individuals without distinction of race, sex or socioeconomic status will be included. In addition, participants should be in good general health. Informed Consent Form (TCLE) duly signed. Possess a carious lesion in premolars or molars. Positive response to the cold test with refrigerated gas at -20 ° C (Aerojet, Rio de Janeiro, RJ, Brazil). Negative sensitivity to percussion test. No history of spontaneous pain. Radiographic absence of periapical lesion and / or thickening of the periodontal ligament.	Individuals who use fixed orthodontic appliances, with bands or brackets that impair the appropriate clinical and radiographic examination and the isolation of the operative field. Carious lesions with depth less than 2 mm. Non-residents in study city or city change plan. Individuals with allergy to some study material. Pregnant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:35
RBR-8prx2m	Influence of sleep, exercise and cold application on kicking in socccer	Not yet recruiting	Intervention	2018-10-22	<NULL>	<NULL>	2293	Influence of sleep quality, postactivation potentiation and cold-water immersion on kicking mechanics and performance in young soccer players	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Estadual Paulista	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8prx2m	<NULL>	"Football practitioners, since 6 years-old
Aged between 15 and 17 years old (under 17 group)
Consent form also signed by the parents or guardians."	"Musculosqueletal injury in the last 6 monhts;
Training/ had trained or competing/ had competed at older age groups (e.g. under 20 and professional senior)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-422ssn	Evaluation of Efficacy and Gynecological Acceptability of a Product for Health Care	Not yet recruiting	Intervention	2018-10-25	<NULL>	<NULL>	2301	Evaluation of Gynecological Acceptability of Product for Health Care with Perceived Effectiveness of Hydration and Maintenance of Vaginal pH	<NULL>	3, single-arm-study, single-blind	3	<NULL>	<NULL>	<NULL>	2018-11-16	Medcin Instituto da Pele Ltda	Marjan Indústria e Comércio Ltda	https://ensaiosclinicos.gov.br/rg/RBR-422ssn	<NULL>	33 female participants; aged between 40 and 70 years; with vaginal dryness, presenting normal vaginal mucosa and who want to participate in the research	Gestation or risk of gestation / lactation; Use of anti-inflammatory / immunosuppressive / antihistamine drugs up to 3 weeks prior to screening; active cutaneous conditions; Use of other products in the genital area; Participants who use or intend to use intravaginal or systemic anti-infectives or systemic antifungal therapy during the study; Atopic or allergic history of intravaginal products; Immunosuppression by drugs or active diseases; endocrine disorders; Relevant clinical history or current evidence of alcohol or other drug abuse; Known history or suspected intolerance to products of the same category; Intense sun exposure up to 15 days before evaluation; Dermatological and / or gynecological treatments up to 4 weeks prior to screening;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-5fqjr7	Effects of guarana on physical activity practitioners	Not yet recruiting	Intervention	2018-10-30	<NULL>	<NULL>	2306	Effects of guaraná (paullinia cupana) supplementation on the regulation of oxidative stress and on blood biomarkers after physical exercise in physical activity practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-05	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5fqjr7	<NULL>	"Age between 18 and 30 years;
Do not use medicines;
That they never answer &quot;yes&quot; to the Par-Q questionnaire;
That they accept to participate in the study without any type of remuneration, besides the aid of cost related to the trip to the university in the days of the collections."	"Initiate the use of any medication during the experimental phase of the research;
Suffer some injury that is not related to the symptoms of fatigue;
Miss one of the protocol days;
Ask to leave the survey."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-62wfjg	Ventilation Effects of Two-Phase Pressure compared to conventional ventilation in patients hospitalized in the ICU with community-acquired pneumonia	Not yet recruiting	Intervention	2018-11-01	<NULL>	<NULL>	2310	Effects of Ventilation Positive Biphasic Pressure compared to Protective Ventilatory Strategy in intensive care patients with Community-Acquired Pneumonia: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Hospital Pró Cardíaco	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-62wfjg	<NULL>	Signs and symptoms of pneumonia according to current guidelines; Age greater than 18 years;Being on invasive mechanical ventilation for up to 24 hours;Free and informed consent form obtained from the family	Transplantation (Organ and / or bone marrow);HIV positive;Immunosuppressive treatment (Corticosteroid);Tuberculosis; Hospitalization in other ICUs or emergency department in the last 14 days; Pregnancy; morbid obesity;severe liver disease;Pneumothorax;Clinical decision on palliative care;Estimated duration of mechanical ventilation less 48 hours;Neoplasms and neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-7vznbt	Effects of a Treadmill Walking Program on stationary and moving balance in the elderly in nursing homes	Not yet recruiting	Intervention	2018-11-06	<NULL>	<NULL>	2316	Effectiveness of a Treadmill Training Programme in improving the postural balance on institutionalized older adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7vznbt	<NULL>	Functional Ambulation Categories (FAC) &gt;2; absence of cognitive deficit in the Mini-Mental State Examination (MMSE) according to educational level; absence of physical and/or functional impairment that would limit treadmill walking.	Untreated neurological or cardiorespiratory diseases; limitation of the ability to walk on the treadmill; incapacitating visual or hearing deficits that would not permit the investigation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:36
RBR-5qmqnq	Risk for Heart Disease and Physical Therapy in Primary Prevention	Not yet recruiting	Intervention	2018-11-07	<NULL>	<NULL>	2319	Cardiovascular Risk and Physical Therapy in Primary Prevention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-31	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-5qmqnq	<NULL>	"Age greater than or equal to 20 years;
both sexes"	"Individuals who notice excessive discomfort for the hair puncture;
or with incapacity to understand the booklet or any other aspect, that prevent the accomplishment of any stage;
carriers of proven cardiovascular disease and / or under medication for these diseases;
respiratory, genetic, hematological, oncological or other active diseases or with identifiable sequelae"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-8tb49z	Evaluation of mobile application effectiveness for caregivers of dementia elderly	Not yet recruiting	Intervention	2018-11-08	<NULL>	<NULL>	2322	Construction, validation and evaluation of mobile application for informal caregivers of demented elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-19	Universidade Estadual do Ceará - UECE	Associação Brasileira de Alzheimer- Regional Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8tb49z	<NULL>	Be an informal caregiver of an elderly person  with dementia; have an age of 18 years or more; being in the function of informal caregiver for the minimum period of 60 days; be literate; have some familiarity with the use of mobile electronic devices (smarthphone, tablet); have electronic device of the type smarthphone or tablet; accept the storage of the mobile application developed on your smarthphone or tablet; present suggestive scores of overload in two of the subscales of the Caregiver Reaction Assessment (CRA), version adapted and validated for use in Brazil.	To present some cognitive limitation of response to baseline information (questionnaires and instruments).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-928rqc	The effect of Functional Cognitive Therapy (CFT) in patients with Chronic Lumbar Pain submitted to Surgery in Lumbar	Not yet recruiting	Intervention	2018-11-08	<NULL>	<NULL>	2324	Biopsycosocial effect of Functional Cognitive Therapy (CFT) in patients with Chronic Lumbar Pain submitted to Surgical Intervention in Lumbar	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-29	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-928rqc	<NULL>	"Age between 18 and 75 years;
A history of chronic low back pain lasting at least 12 weeks;
Pain equal to or greater than 3 points END;
Surgical intervention in the lumbar spine after 3 months or more;
To those who maintained pain and / or disability after surgery on the lumbar spine;
Score 14% or more for dysfunction in the Oswestry Disability Index;
Being able to walk independently with or without help;
Understand the Portuguese language of Brazil well enough to complete the questionnaires."	"Presence of red flags such as fracture, malignancy / cancer, equine tail syndrome or progressive neurological disorder, inflammatory or infectious diseases of the spine;
Suspected or confirmed pregnancy;
Suspicion of radicular pain, dominant leg pain, positive tests of neural tissue provocation and / or altered strength, reflex or altered sensitivity to the same nerve root, both evaluated clinically;
Unstable heart conditions.
All individuals will be clarified about the objectives and procedures performed in the research and will sign the Free and Informed Consent Form approved by the Ethics Committees of the Federal University of Santa Catarina - UFSC and the Governador Celso Ramos Hospital - HGCR."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-5ndvwr	Effects of an Exercise Program on the Cardiovascular System and Physical Endurance of Chronic Renal patients undergoing hemodialysis.	Not yet recruiting	Intervention	2018-11-09	<NULL>	<NULL>	2327	Effects of a Resistance Exercise Program on the Autonomic Cardiovascular Function and without Physical Conditioning of Chronic Renal patients under hemodialysis treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-10	Hospital Universitário da Universidade Federal do Maranhão	Clínica de Rim e Hipertensão Arterial	https://ensaiosclinicos.gov.br/rg/RBR-5ndvwr	<NULL>	Age greater than 18 years; both genders; undergoing hemodialysis for more than 3 months; who have the cognitive ability to understand the research process and sign the informed consent form; volunteer to participate in the study.	Patients with diseases or some type of musculoskeletal disability; bone or joint disorders that make evaluations and exercise protocol impossible; dialysis by catheter in the femoral artery or catheter in the jugular vein; neurological and behavioral changes that in some way render the protocol inapplicable; patients with severe cardiovascular disease; patients presenting hematocrit less than or equal to 30% and / or hemoglobin less than or equal to 10g / D; patients with untreated mitral or aortic insufficiency / stenosis; severe pulmonary conditions; pathologies that incapacitate the study (amputation of upper limbs or lower limbs, amaurosis, deep venous thrombosis); patients who already had resistance exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-4c3fz2	Comparison of muscle activity of the trunk and legs in Equine therapy and in the gait of people with Down Syndrome, Cerebral Palsy and Intellectual Deficiency	Not yet recruiting	Intervention	2018-11-09	<NULL>	<NULL>	2333	Eletromiography analisys of the trunk and inferior limbs on the hippotherapy in comparision with the independent gait in subjects with Down Syndrome, Chronic not-progressive encephalopathy of childhood and Intellectual disabilities	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-02	Universidade Federal do Triângulo Mineiro	Associação de Pais e Amigos dos Excepcionais de Uberaba - APAE	https://ensaiosclinicos.gov.br/rg/RBR-4c3fz2	<NULL>	Medical referral; be regularly enrolled in APAE / Uberaba-MG; present independent gait; both genders; aged between 5 and 18 years; signature of the term of responsibility for the practice of equine therapy by parents and / or guardian; Free and Informed Consent signed by parents and / or guardians; medical diagnosis according to each group (Cerebral Palsy, Down Syndrome and Intellectual Disability); the Cerebral Palsy group, only the spastic diparetic type individuals will be included.	individuals with uncontrolled seizures; instabilities in the spine; herniated disc; shoulder and / or hip dislocations; scoliosis above 42 degrees; acute phase rheumatic processes; acute heart diseases; hydrocephalus with valve; uncontrollable fear of the animal, associated syndromes and / or behavioral changes; difficulty understanding commands / tasks; do not make frequent use of drugs such as botulinum toxin that interfere in muscle activity specifically of the muscle groups to be evaluated in this study; abandonment and / or 2 consecutive absences.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-5dfnxg	"Safety evaluation of cosmetic products by 
gynecologist and dermatologist in normal conditions of use"	Not yet recruiting	Intervention	2018-11-19	<NULL>	<NULL>	2339	Gynecological and dermatological aceitabiity evaluation of cosmetics products in normal conditions of u	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-10	Ipclin - Pesquisa Clínica Integrada	Avenca Indústria Cosmética	https://ensaiosclinicos.gov.br/rg/RBR-5dfnxg	<NULL>	Female. Age 18 to 65 years. Phototype I to IV. Intact skin in the test area. Occasional user of the category products.	Cutaneous marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn). Pregnant women or infants. Subjects with a history of allergy to the material used in the study. History of atopy. Use of vaginal cream. Subjects with a history of allergy to cosmetic products of the tested category. Recent gynecological surgeries. Vaginal discharge. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Active cutaneous pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis). Topical use of corticosteroids in the experimental area up to 8 days before the start of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-98xmss	Effectiveness of strategies in adherence to diagnostic method guidelines in cancer patients.	Not yet recruiting	Intervention	2018-11-19	<NULL>	<NULL>	2340	Effectiveness of implementation strategies in adherence to PET / CT guidelines in cancer patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-98xmss	<NULL>	Physicians specializing in oncology, hematology, proctology, thoracic surgery, pneumology, radiotherapy, pediatric oncology; To present care of SUS patients with a diagnosis of cancer with indication to PET/CT.	Not applicable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:37
RBR-7hg48k	Validation of a psychological distress screening tool in the emergency room	Not yet recruiting	Observational	2018-11-29	<NULL>	<NULL>	2350	Validation of a psychological distress screening tool in the emergency room	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Hospital das Clínicas Universidade Federal de Goiás - GO	Residência Multiprofissional em Saúde - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7hg48k	<NULL>	Patients admitted to the Emergency Room of the Hospital das Clínicas, Federal University of Goiás; both sexes; age from 18 years; without distinction of race, marital status, socioeconomic status and time of illness.	Patients who do not consent to participate in the research; patient who do not present their mental faculties preserved, according to the results presented in the Mine Mental State Examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-5hgxy8	A double-blind randomized clinical trial applied to lower limb diabetic ulcers using a combination of biomembrane derived from natural latex (Hevea Brasiliensis) and  light emitting equipment	Not yet recruiting	Intervention	2018-12-05	<NULL>	<NULL>	2366	"Randomized double-blind clinical trial in diabetic ulcers of lower limbs using biomembrane association derived from natural latex
(Hevea Brasiliensis) and  light emitting equipment varied wavelength 450 to 636 nm"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade do Gama	Universidade de Brasilia	https://ensaiosclinicos.gov.br/rg/RBR-5hgxy8	<NULL>	"Patients aged between 18 years and 75 years;
with history of diabetes mellitus type I or II; to present a single type A1 or A2 diabetic foot ulcer (University of Texas classification, with indication of outpatient treatment, without infection and without indication of surgical debridement, with a history of diabetic foot ulcer of more than 6 weeks duration and less of 12 months, have no allergy to latex, intellectually fit, have a cell phone with the ability to take photographs and have the application WhatsApp"	Diabetes mellitus uncontrolled with glycated Hb&gt; 10 g / dl; irregular use of medication for the disease or even without regular medical follow-up; evidence of osteomyelitis or gangrene at either end; have lesions with excessive exudate; be an active smoker, regular user of alcoholic beverages and / or illicit drugs; another chronic disease that at the discretion of the investigator compromises the participation in the study; pregnant or lactating women or women of child-bearing age without adequate contraception; participation in another clinical study in less than 1 year (unless justified by the researcher)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:38
RBR-9832jt	Effect of the use of L-Arginine, Caffeine or Creatine supplements associated with physical activity in women with Polycystic Ovary Syndrome with Metabolic Syndrome	Not yet recruiting	Intervention	2018-12-12	<NULL>	<NULL>	2381	Thermogenic Adaptation in Patients with Polycystic Ovarian Syndrome with Metabolic Syndrome Supplemented by Chronology with L-Arginine, Caffeine or Creatine and Training Resisted Exercise - Randomized Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Mato Grosso	Instituto Tropical de Medicina Reprodutiva e Menopausa	https://ensaiosclinicos.gov.br/rg/RBR-9832jt	<NULL>	Women with PCOS who present a metabolic syndrome, with a total age of 20-35 years in the period of the research, who are sedentary or do not practice more than two days of physical exercise, will be selected in the INTRO database , and to sign the Free and Informed Consent Form (TCLE).	Women who are not within the age range standardized by this research, ie obese women with SOP or SM, women who use steroids or other drugs that may interfere with metabolism, hyperprolactinemia, hypo / hyperthyroidism, congenital adrenal hyperplasia classical and non-classical Cushing&apos;s disease and tumors of ovary or adrenal secreting androgen women who are pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-2cyp7c	Effects of the use of colostrum as an oral therapy in very low birth weight preterm infants under the Unified Health System (SUS)	Not yet recruiting	Intervention	2018-12-17	<NULL>	<NULL>	2387	Colostrotherapy, nutrition, pondero-estatural growth and morbimortality of preterm infants of very low weight attended by the Unified Health System (SUS): intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Estadual de Feira de Santana	Hospital Inácia Pinto dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-2cyp7c	<NULL>	Infants admitted to Neonatal Units; birth weight less than or equal to 1500g; less than or equal to 37 gestational weeks; zero diet by oral and enteral route or in total parenteral nutrition; clinically stable; until 24 hours of life.	Referring to the mother: maternal history of substance or drug abuse; presence of psychological disorder; multiple gestation from triplets; contraindications for breastfeeding (retroviruses and cytomegalovirus). Regarding the newborn: use of vasopressor medication greater than 10mcg / kg / min; needing for immediate surgical intervention; presence of syndromes and / or congenital malformations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:39
RBR-7k6v3v	Influence of meal frequency on reduced energy diet in body weight loss, blood sugar, blood fats, ghrelin hormone in the blood and energy expenditure of obese women	Not yet recruiting	Intervention	2018-12-18	<NULL>	<NULL>	2393	Influence of the frequency of meals in the hypocaloric diet in the loss of body weight, glycemia, Serum lipid profile, plasmatics ghrelin and energetic expenditure of obese women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-14	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7k6v3v	<NULL>	Adult women 20 to 59 years of age, obese, with a body mass index (BMI) equal to or greater than 30 kg / m2 (WHO, 1988), of any race or color, not menopausal, who have not changed body weight and who have not diet to lose weight in the last 3 months.	Women will not be included athletes, users of medication or supplements for weight control, smokers, alcoholics, with cardiac complications, clinical diagnosis of diabetes mellitus, pregnant women, infants, illiterates and those with diseases such as cancer, liver diseases and severe nephropathies. Women who do not comply with all the protocol proposed during the intervention or that present intercurrences that interfere with their eligibility during the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:40
RBR-76vccv	Association of Laser and Microneedling in Female Baldness.	Not yet recruiting	Intervention	2018-12-20	<NULL>	<NULL>	2402	Association Fotobiomodulation and Microagulhamento Hair Loss in Female Pattern (FPHL): clinical study, randomized, double-blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-76vccv	<NULL>	This study will be conducted in women; aged between 18 and 60 years; who present the female capillary fall; telogen effluvium profile; and androgenetic alopecia; Women with capillary rarefaction; Great hair loss in the last five years; gradually in the last year; they are able to perform no chemical procedure for the period of 3 months.	Scalp scarring; wear wigs; use appliqués that cause weight on the stem; use drugs continuously as anti-inflammatories; anxiolytics; antifungals; hormonal inhibitors; Have fungal or inflammatory conditions; women undergoing hormonal gynecological treatment; Uncontrolled chronic diseases such as Arterial Hypertension; diabetes; Participants unable to understand and sign the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-7vgnk2	Low intensity laser therapy associated with Chamomile and Calendula in the treatment of oral Mucositis	Not yet recruiting	Intervention	2018-12-26	<NULL>	<NULL>	2404	Low intensity laser associated with matricaria recutita linn and calendula officinalis in the treatment of oral Mucositis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Fundação Valeparaibana de Ensino	Universidade do Vale do Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7vgnk2	<NULL>	Age between 19 and 30 years; presence of oral mucositis grade; patients receiving similar treatment protocols; patients able to cooperate with the protocol established by the research; patients capable of performing the oral hygiene protocol; patients who accept the terms proposed in this study and sign the informed consent form.	Patients who present some allergic reaction to any of the plants used in this study, or have a history of any adverse reaction to the family Asteraceae or Compositae, will be excluded; Receiving oral or intravenous anticoagulant therapy; Use topical or systemic therapy with anti-inflammatories; receive another type of standard or experimental protocol for the treatment of oral mucositis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-37wrrs	The influence of counseling on the duration of exclusive breastfeeding	Not yet recruiting	Intervention	2018-12-27	<NULL>	<NULL>	2411	Breastfeeding counseling at home: the impact on exclusive breastfeeding	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-37wrrs	<NULL>	"GESTANT: That intends to breastfeed; That you accept to participate in the research in prenatal and later in the puerperium. 
PUERPERA AND NEWBORN: Puerper who participated in the research since the gestation; That the delivery occurred with Gestational Age (GI) equal to or greater than 37 weeks; Newborn with birth weight equal to or greater than 2,500 g."	PREGNANT: Multiple gestation; Child donation plans; Mental restrictions that make it impossible to understand the instrument; Important clinical settings in which breastfeeding is contraindicated (HIV, HTLV, use of illicit narcotic substances, etc.). PUERPERA AND NEWBORN: Change of residence of the area of coverage of the Family Health Strategy that belonged to the gestation; Childbirth and / or postpartum with important obstetric complications that make breastfeeding difficult (severe hemorrhage, etc.); Congenital malformations of newborns that may contraindicate or complicate breastfeeding; newborn sent to the Neonatal Intermediate Care Unit, Neonatal Intensive Care Unit, or equivalent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-5k7pnr	Evaluation of the caracteristics of patients with spinal tuberculosis  in a  hospital in the city of São Paulo.	Not yet recruiting	Observational	2019-01-11	<NULL>	<NULL>	2437	Evaluation of the clinical and epidemiological profile of Tuberculous Spondylodiscitis in a quaternary hospital in the city of São Paulo.	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-03-10	Irmandade da Santa Casa de Misericórida de São Paulo	Irmandade da Santa Casa de Misericórida de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5k7pnr	<NULL>	Both genders; age: 1 day of life up to 100 years; diagnosis of tuberculosis of the spine. Diagnosis will be defined by: isolation of the etiological agent or by clinical and radiographic criteria characteristic of tuberculosis vertebral involvement and or pathological examination compatible with tuberculosis and / or positive therapeutic test. Isolation of the agent will be considered the presence of BAAR by the Ziehl-Neelsen method, molecular rapid test (real-time PCR) and culture for mycobacteria. The radiographic findings are visualized in radiographs of the spine according to the affected level, in the posteroanterior and profile incidences, with the following findings: aneurysmal abscess, sacral lesions, disc space reduction, vertebral collapse, kyphosis, calcification. The findings found on computed tomography are a decrease in the height of the vertebral body, osteolysis in the terminal plates of the vertebral bodies adjacent to the disc, pre-vertebral abscess, paravertebral abscess. Magnetic resonance imaging findings are hyposignal of the affected disc in weighted images at t1; hypersignal of the disc and the vertebral plateaus adjacent to the disc in t2-weighted images; epidural involvement; paraespinal abscess with a smooth abscess wall. Clinical Criteria: Indolent chronic infection associated with leukocytosis and changes in inflammatory tests, CRP and HSV, associated or not with the positive tuberculin test; Anatomopathological examination: The presence of epithelioid macrophage proliferation constituting confluent granulomas with presence of giant Langerhans cells with central foci of caseous necrosis and surrounding lymphocytic infiltrate was considered a characteristic of TB, with positive BAAR using the Ziehl-Neelsen method . The samples were submitted to routine methods for optical microscopy: 10% formaldehyde fixation, paraffin blocks cut into a 3 micron thick microtome and stained by hematoxylin-eosin (HE), Grocott (for fungi research) and Ziehl-Neelsen (for the BAAR survey). The biopsies were processed according to routine of the laboratory of Pathological Anatomy;	Do not meet the criteria for definition of tuberculo spondylodiscites case; incomplete Medical Record; incomplete image checks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-89z57d	Effect of Reiki on people&apos;s well-being and feelings	Not yet recruiting	Intervention	2019-01-16	<NULL>	<NULL>	2446	Reiki&apos;s interference in subjective well-being and positive and negative feelings	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-09	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89z57d	<NULL>	To be a server of the Federal University of Sergipe; to have never experienced therapy before; to be 18 years or older; to read and write; to commit voluntarily to four sessions of Reiki and; to respond to the instruments of collection of data	As exclusion criteria, physical and intellectual inability to respond to the questionnaires that were applied and to be on vacation or on leave in the institution was considered as exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-3pz4dh	Effects of a home exercise program of strength and cardiopulmonary resistivity in patients with Chronic Renal Disease	Not yet recruiting	Intervention	2019-01-18	<NULL>	<NULL>	2448	Effects of a household program of exercises in patients with Chronic Renal Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3pz4dh	<NULL>	"Diagnosis of kidney disease for more than 6 months.
Patients undergoing hemodialysis at the HCPA Nephrology Service for at least 3
months.
Age equal or superior to 18 years.
Physical conditions to perform exercises and the tests proposed in this study.
CKD stability for at least 30 days, defined by the absence of
hospitalization and / or modification of the usual therapeutic regimen."	"Presence of acute myocardial infarction in the last 3 months.
Presence of pacemakers and defibrillators making it impossible to perform the
Bioimpedance.
Active inflammatory or infectious process, evidenced by leukogram outside the
limits of normality.
Decompensated coronary artery disease.
Peripheral arterial disease.
Implantable kidney transplant candidate with live or predicted donor
transplant in the next 3 months.
Cognitive, auditory and visual changes that limit the understanding of
evaluations and interventions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-9q7gg4	Influence of protein and creatine supplementation on the ability to perform daily living activities, quality of life and muscle structure after stroke	Not yet recruiting	Intervention	2019-01-21	<NULL>	<NULL>	2450	Influence of Protein and Creatine supplementation on functional capacity, quality of life and muscle function after Stroke	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade de Medicina da Unesp de Botucatu	Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9q7gg4	<NULL>	Men older than 60 years; diagnosed with ischemic stroke; with up to 24 hours of stroke; without previous disability (Modified Rankin Scale less than 1) and who agree to participate of the study.	Patients with hemodynamic instability; in mechanical ventilation / ICU; use of pacemaker and metal prostheses; with previous renal disease; with creatinine clearance less than 30ml / min / 1.73m²; using alternative route for feeding (nasoenteral tube / gastrostomy / parenteral nutrition); patients with allergy or intolerance to any component of the study products and those who do not agree to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-7kppn2	The effect of movement velocity on the performance of leg press exercise in the musculature of elderly women with knee arthrosis	Not yet recruiting	Intervention	2019-01-21	<NULL>	<NULL>	2451	Acute effect of moviment velocity on kinetic and kinematic behavior and muscle activation in women elderly with knee osteoarthritis during leg press exercise	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-18	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	https://ensaiosclinicos.gov.br/rg/RBR-7kppn2	<NULL>	"Age over 65 years;
diagnosis of osteoarthritis of the knee using the criteria for osteoarthritis of the knee of the American College of Rheumatology (ACR, 1986) or to have grade II or III knee osteoarthritis of the Kelgren and Lawrence (KL) scale;
walking independently, without support device;
being for at least six months without practicing resisted physical exercise;
and do not present as follows:
any congenital, traumatic, infectious or deformity abnormality following injury to the knee joint that may have contributed to the development of secondary OA;
inflammatory arthritis (e.g., Rheumatoid Arthritis);
grade IV knee osteoarthritis on the KL scale;
knee flexion deformity greater than 15 degrees;
inability to walk or walk with the aid of devices;
neurological problems;
neuromuscular disease or injury;
surgery on the knee (s) in the last year;
corticosteroid injection in the last three months;
uncontrolled hypertension (&gt; 150/90 mmHg);
myocardial infarction in the last six months;
unstable cardiovascular disease;
conditions that may be exacerbated by the protocol (e.g., unstable angina);
fractures within the six-month period; present painful changes in the hips and / or ankles and / or pain in the lower back; or severe comorbidity that limits participation in the study.
Clinical guidelines established by the ACR include having knee pain on most days of the month and at least 3 of the following 6 criteria: age 50 and older, joint stiffness lasting 30 minutes, crepitation, bone sensitivity, bone augmentation, and heat palpable."	"Not participating in one of the sessions;
Any limitation that impedes the continuity of the participant in the study;
Participants with BMI&gt; 30 kg / m2 (minimize artifact at EMG)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-2p8rrh	Evaluation of the effects of microphysiotherapy in women with fibromyalgia.	Not yet recruiting	Intervention	2019-01-21	<NULL>	<NULL>	2452	Evaluation of the effects of microphysiotherapy on quality of life, heart rate variability, biochemical markers and pain in individuals with fibromyalgia.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2p8rrh	<NULL>	"Inclusion criteria will be considered: women living in the
Florianópolis and in the cities of Capão Bonito-SP, São Paulo-SP, Pinhão-PR
and Guarapuava-PR aged 18 to 80 years, with the clinical diagnosis of FM.
In addition, after the inclusion will have to have the signature of the Term of Consent
Free and Informed (ICLE)."	"The exclusion criteria adopted will be: patients with
immunodepressive agents; oncological; infectious diseases; cardiovascular, renal,
hepatic, gastrointestinal or psychiatric disorders, use of anti-inflammatory drugs
or drugs that affect the inflammatory process (before and after a week of
collection of blood), pregnant or lactating, degenerative changes in the spine,
herniated discs with motor deficit, post-surgical spine or rheumatic diseases,
will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-8rkwnw	Effects of Arginine Supplementation associated with an Exercise Training Program in Chronic Obstructive Pulmonary Disease	Not yet recruiting	Intervention	2019-01-22	<NULL>	<NULL>	2453	Effects of Arginine Supplementation associated with Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-31	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8rkwnw	<NULL>	Patients with moderate to very severe chronic obstructive pulmonary disease; with age equal to or greater than 40 years; of both sexes.	Current smoking; presence of associated diseases that make it impossible to carry out any of the study evaluations or limit the progression of training such as osteoarthritis, severe cardiovascular and neurological conditions and non-signing of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-22zvxw	Bone metastases treatment by image-guided freezing in patients with endocrine tumors	Not yet recruiting	Intervention	2018-07-03	<NULL>	<NULL>	2455	Cone-beam computed tomography guided percutaneous cryoablation approach of bone metastases of endocrine tumors	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Instituto de Radiologia do Hospital das Clínicas / Faculdade de Medicina da Universidade de São Paulo	Instituto do Câncer do Estado de São Paulo - ICESP	https://ensaiosclinicos.gov.br/rg/RBR-22zvxw	<NULL>	patients with bone metastases diagnosis evidenced by imaging exams (CT, MRI and/or PET-CT) and secondary to: papillary, folicular or medullary thyroid cancer; adrenal carcinoma; neuroendocrine carcinomas; metastatic bone lesions associated with: pain; risk of fracture; risk of spinal cord compression; hypercalcemia; age over or equal 18 years old; performance status (ECOG) of 0, 1, 2 or 3; life expectation over one month; patients must present pain symptoms from bone metastases and / or localized in a region of imminent risk of instability / fracture that may progress to neurological complication (for example, vertebral metastases) or functional impairment (for example, acetabular metastases); all patients must present diagnosis confirmation from metastases biopsy; the same treated patients can be treated again if they present new lesions during the study; all patients must be evaluated for treatment indication by a multidisciplinary team; the metastatic lesions may be located at the axial skeleton, costal arches, shoulder or pelvic girdle; each bone metastases assigned for treatment must be biopsy-proven and / or presenting elevation of thyroglobulin or calcitonin levels in the needle wash, if thyroid carcinoma is present; all patients must present five symptomatic bone metastases maximum; all selected metastases must have 7.0 cm diameter maximum;	"age bellow 18 years-old; active anticoagulant treatment
non-conclusive or benign cytologic specimens
pregnancy or breast-feeding undifferentiated thyroid neoplasia (anaplastic)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:43
RBR-5fhmpq	Clinical evaluation of a dental adhesive containing zinc and copper nanoparticles in composite resin restorations in dental lesions near the gingiva	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2473	Clinical Evaluation of an Universal Adhesive System containing Zinc and Copper Nanoparticles on Composite Restorations in Non-Carious Cervical Lesions: a Double-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-11	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5fhmpq	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-3pq5th	Use of phone calls in the prevention of diabetic foot	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2475	Evaluation of the use of telephone intervention in the prevention of diabetic foot	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-07	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3pq5th	<NULL>	Those who are 18 or older will be included in the study; patients diagnosed with Diabetes mellitus for at least 2 years with or without arterial hypertension; have a fixed telephone line or personal cellular telephone.	And exclusion criteria will be: to have the diabetic foot and some cognitive deficit that makes it impossible to respond directly to the instruments of collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-8hnvm7	Comparison of Phototherapy versus Therapeutic Ultrasound in the Treatment of Shoulder Injury	Not yet recruiting	Intervention	2019-02-11	<NULL>	<NULL>	2476	Comparison of the red and infrared LEDs in relation to therapeutic Ultrasound treatment on chronic Tendinopathy of shoulder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Anhembi Morumbi	Universidade Anhembi Morumbi	https://ensaiosclinicos.gov.br/rg/RBR-8hnvm7	<NULL>	Medical diagnosis characterized as chronic tendinitis of the shoulder, sign the document informed consent, age between 45 and 70 years, and not using anti-inflammatory or analgesic medication at the time of the study	No chronic tendinitis of the shoulder, age out of the studied range, using anti-inflammatory or analgesic drugs, presenting other pathologies associated with tendinitis, presenting neoplasm, patients with photo sensibility, treated with other methods recently	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-4q83kx	Evaluation of sleep, quality of life and ability to perform exercise before and after the use of an apparatus to treat sleep disorders in adults with non-fibrocystic bronchiectasis and obstructive sleep apnea	Not yet recruiting	Intervention	2019-02-12	<NULL>	<NULL>	2478	Evaluation of sleep quality, quality of life and functional capacity pre and post-PAP and its repercussions in adults with non-cystic fibrosis bronchiectasis and obstructive sleep apnea - a three months follow-up study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Centro Universitário Augusto da Motta	Centro Universitário Augusto da Motta	https://ensaiosclinicos.gov.br/rg/RBR-4q83kx	<NULL>	Patients with clinical diagnosis of BNF (after confirmation by HRCT and sweat test) of both genders; between 18 and 90 years old; after agreeing to participate in the study; signing the ICF; with no cognitive deficit that would interfere in the comprehension to answer the questionnaires; clinical stability at least 1 month; long-term bronchodilator use; presence of OSA confirmed by PSG.	Patients with bronchiectasis due to CF (chloride level in sweat&gt; 60 mmol / L); smoking history; presence of other pulmonary diseases (eg COPD and asthma) and / or other comorbidities that could influence the diagnosis and/or prognosis in the outcome of the disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:44
RBR-92r54q	Autonomic heart modulation in children and adolescents with Cerebral Palsy during task using virtual Technology	Not yet recruiting	Intervention	2019-02-25	<NULL>	<NULL>	2488	Autonomic cardiac modulation in children and adolescents with Cerebral Palsy during Virtual Reality task and its correlations with participation and functionality	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-09	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92r54q	<NULL>	Children and adolescents of both groups should be aged from 5 to 21 years old, also they must have a clear understand of the proposed activities. Statement of informed consent will be signed by a legal guardian. All participants from the experimental group (GCP) should have diagnosis of cerebral palsy. Additionally, they should be classified at levels I, II, or III of the Manual Ability Classification System (MACS). To standardizes the sample according to ICF, participants with CP should present musculoskeletal functions in the mobility of several joints of the upper limbs with mild and moderate deficiencies (b7101.1 and b7101.2), trunk muscle tonus with mild deficiency (b7355.1) and mild or moderate upper limb tonus (b7358.1 and b7358.2). Regarding to learning, application of knowledge, accomplishment of tasks and communication all individuals will have light deficits in concentration and attention (d160.11), in performing a simple task (d2100.11) and in receiving oral messages (d310.11). These domains were chosen because they are the most important to enable the execution of the proposed task of touching the computer key at the exact moment or enabling to move towards the virtual environment.	Children that have undergone surgical procedures or has taken neurolytic block 12 months prior to the training sessions will be not included in the present research. Children with Gross Motor Function Classification System (GMFCS) level V (most severe CP) or who have severe visual or hearing impairments, or photosensitive epilepsy will be excluded. Furthermore, children with other pathologies and secondary disabilities will also be excluded, such as orthopedic deformity with indication for surgery, Epilepsy, Metal implant in the skull or use of hearing aids. ?	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-6fgg7b	Effect of Cognitive Stimulation on falls in the elderly	Not yet recruiting	Intervention	2019-02-26	<NULL>	<NULL>	2490	Effect of Cognitive Stimulation on the prediction of Falls in physically active elderly people	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6fgg7b	<NULL>	Do not have dementia; Do not present severe visual impairment or blindness;Do not present severe hearing loss or deafness; No hemiparesis or hemiplegia due to stroke; Do not present neurodegenerative disease; such as: Parkinson&apos;s disease, Alzheimer&apos;s; Multiple Sclerosis; Amyotrophic Lateral Sclerosis; among others; To be able to wander without using an auxiliary gear; Have the proper medical control of chronic diseases and risk factors; according to medical guidance. Example; Diabetes mellitus and Systolic Arterial Hypertension controlled by drug; ccording to the prescription of a doctor;	1. miss to 25% or more of the total number of meetings held; 2. Suffering hospitalization due to serious reason or hospitalization for more than 24 hours; 3. By choice, leave the research; 4. Suffering Stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7n55nz	Effect of Lasertherapy in Patients with High Blood Pressure	Not yet recruiting	Intervention	2019-02-27	<NULL>	<NULL>	2493	Effect of Irradiation with Intravascular Laser on Hemodynamic Variables of Hypertensives Patients: Study Protocol for Blinded Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	Associação Educacional Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-7n55nz	<NULL>	Hypertensive individuals with ages between 30 and 80 years; with a diagnosis of systemic arterial hypertension declared by medical certificate stages I or II and evidenced in ambulatory blood pressure monitoring; with drug therapy of at least 4 weeks.	Patients with hypotension prior to the application of laser; pregnant women; with glaucoma diagnosis;  using electronic implants - such as a cardiac pacemaker; with epilepsy; seizures;  history of neoplasias; photosensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-4kkq2h	Silver Hydrofibrate versus collagenase curative in the control of venous ulcer infection: a randomized clinical trial	Not yet recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2501	Hydrofiber with silver versus colagenase in the control of surface infection and biofilms of venous ulcers: randomized clinical trial	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4kkq2h	<NULL>	Participants will be the adult patients who were seen at the Chronic Ulcers Clinic of the Faculty of Medicine of Botucatu during the study period, presenting an age of 18 years or older, chronic venous ulcer, open ulcer over 6 weeks, with clinical signs of infection superficial.	"Ulcers of other etiologies (peripheral arterial disease, haematological causes, neoplastic, infectious, etc);
Infected ulcers, that is, when associated with erysipelas, cellulitis or lymphangitis due to the need for systemic antibiotic therapy;
Have a history of hypersensitivity to the treatments proposed.
Have venous ulcer associated with peripheral arterial disease that will be characterized when the ankle-arm systolic index  is less than 0.8 and / or absence of distal pulses, mainly tibial.
Patients will be assessed clinically and with a script to characterize venous ulcer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-9crkxr	Barriers to perform home tasks oriented soon after stroke.	Not yet recruiting	Intervention	2019-03-01	<NULL>	<NULL>	2502	Barriers to orientation adherence for the practice of home-based tasks in the subacute post stroke phase.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9crkxr	<NULL>	Individuals with primary stroke; individuals with subacute AVE; No cognitive problems that impair participation in the research, evaluated through the Mini Mental State Examination (MMSE), presenting scores higher than 13 for illiterates and 18 points with school instruction (BERTOLUCCI et al, 1994); Age above 18 years; Residents of the region of Florianópolis and Greater Florianópolis; Do not have other neurological deficits (eg Parkinson&apos;s disease) and / or orthopedic not related to stroke.	Presence of hearing disorders that may compromise communication with the evaluators, presenting another stroke event or other health emergency that requires hospitalization during the period of data collection; not to remain in the home environment after hospital discharge in the subacute phase after stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-7fqyyd	Efficacy of virtual reality exposure therapy for the fear of flying.	Not yet recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2503	Efficacy of virtual reality exposure therapy for the fear of flying: a randomized controlled trial.	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Universidade Federal do Rio de Janeiro	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-7fqyyd	<NULL>	DSM criteria for specific phobia of airplanes; subclinical panic disorders; subclinical agoraphobia (provided that panic symptoms do not interfere with VR exposure); generalized anxiety disorder (GAD), since flying is the main stimulus of fear; signing a form consent.	Participants who are not literate; psychopathological disorder that require immediate treatment; suicide risk; mentally retarded; dependence of psychoactive substances; cardiovascular or respiratory disease presenting some risk; pregnant; psychotic disorder; antisocial personality disorder; schizophrenia; mania; participants in concomitant psychotherapeutic treatments; epilepsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-43hccm	Heart Rate Variability and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-03-04	<NULL>	<NULL>	2507	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-43hccm	<NULL>	The patient should be aged between 20 and 59 years old and be a kidney transplantation patient for at least six months. Patients should be attended in University Hospital of Federal University of Maranhão, have a medical record number, systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively, serum hemoglobin greater than 9 g / dL, glycated hemoglobin (HbAlc) less than 11 percent and be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease, congestive heart failure, active coronary disease and recent acute myocardial infarction and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:45
RBR-3ppmcw	Phone calls for guidelines on Insulin Application	Not yet recruiting	Intervention	2019-03-11	<NULL>	<NULL>	2516	Phone Support in the Application of Insulin	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3ppmcw	<NULL>	"The study will include those
have an age equal to or greater than 18
years; patients with a diagnosis of
Diabetes mellitus for at least 2 years
associated or not with arterial hypertension; use of insulin; have a fixed telephone line or a cellular telephone for personal use."	Cognitive deficit reported by the participant or family member that makes it impossible to respond directly to the instruments of data collection, if it is a health professional who applies insulin and reports having a hearing or speech problem.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-29xb94	Use of Topical Anesthetic Cream for pain relief caused by the injection of Spinal Anesthesia in elective cesarean sections	Not yet recruiting	Intervention	2019-03-15	<NULL>	<NULL>	2528	Use of 2.5% Lidocaine cream and 2.5% Prilocaine cream for analgesia pre lombar puncture of subaracnoideo blocking in programmed cesarians	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Financiamento Próprio	Financiamento Próprio	https://ensaiosclinicos.gov.br/rg/RBR-29xb94	<NULL>	Female patients; over 18 years; pregnant women (above 37 weeks); physical status ASA II; to be submitted to subarachnoid anesthesia for elective cesarean surgery.	"Will not be included in the study: Patients who refuse to participate in the study; patients in labor; who are taking any sedative, opioid or sleep inducing drugs; who have a history of allergy to any drug to be used in the study; severe obesity (defined by a BMI of more than 35 kg.m2), methemoglobinemia, carriers of pathologies that cause some cognitive deficit, such as schizophrenia, oligophrenia, severe depression, etc. If this occurs, the patients will be excluded from the clinical trial, but will not suffer harm in their treatment.
Patients who begin labor during the latency period of topical medication, who require cesarean section before completing 60 minutes after application of the patch containing the cream (anesthetic or placebo), who request their exclusion from the study, will be excluded from the study. study during their performance, who present an allergic reaction during anesthesia or who present partial or total failure of the anesthetic block."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:46
RBR-8zzwfn	Use of Virus-Specific Lymphocytes for Treatment of Patients with Low Immunity After Bone Marrow Transplantation	Not yet recruiting	Intervention	2019-03-20	<NULL>	<NULL>	2534	Expansion of virus specific lymphocytes for cell therapy in immunosuppressed patients submitted to bone marrow transplant	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-03-01	Sociedade Beneficente Israelita Brasileira - Hospital Israelita Albert Einstein	Sociedade Beneficente Israelita Brasileira - Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-8zzwfn	<NULL>	Patients of both sexes. Patients who have undergone allogeneic bone marrow transplantation. Patients who have cytomegalovirus infection or reactivation without clinical improvement or CMV copy decline after at least 2 weeks of treatment with standard anti-viral therapy.	Patients who have received ATG, Campath or other immunosuppressive monoclonal antibody in less than 28 days. Patients who have received infusion of donor lymphocytes in less than 28 days. Patients with other uncontrolled infections than cytomegalovirus. Patients with Grade II to IV active graft versus host disease (GVHD). Patients receiving corticosteroid therapy with equivalent or higher doses of prednisone 0.5mg/kg.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-4493ct	Clinical Evaluation of Ceramic Restorations Glued to the Tooth	Not yet recruiting	Intervention	2019-03-21	<NULL>	<NULL>	2535	Clinical Evaluation of Ceramic Facets Luting with Ceramic Self-Etch Primer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4493ct	<NULL>	Patients older than 18 years, patients with indication for dental contact lenses or ceramic facets, at least from canine to canine, who accept the terms of the research.	Patients smokers, pregnant or lactating, patients with high risk of caries and / or periodontal disease, or patients with some systemic deficiency that prevents periodic monitoring.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:47
RBR-37v2zt	CAD/CAM metal-free single crowns: a clinical study	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2555	CAD/CAM metal-free single crowns: a controlled randomized clinical study	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-05-03	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-37v2zt	<NULL>	Participants from 18 to 60 years old; which are indicated for total crowns on posterior permanent teeth; which are available for clinical follow-up throughout the evaluation period; participants willing to pay for laboratory costs; willing and able to undergo periapical / interproximal radiographic examination when necessary; be in accordance with the Informed Consent Form (TCLE); general health consistent with the clinical evaluation period; maxillo-mandibular relationship and occlusal stability.	History of allergy to some of the materials to be used in the research; pregnancy at the beginning of the experiment; use of drugs that may interfere with the oral environment; systemic or malignant diseases at the start of the study; impossibility to be submitted to the specific techniques for conducting the research; insufficient space for proper preparation of crowns; patients with parafunctional habits; pillars that endodontically and periodontally do not show predictability until the end of the evaluation period; periodontal disease; high risk of caries; absence of more than one tooth in the posterior region; unsatisfactory oral hygiene; use of removable partial dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-9cvrrs	Brazilian Fruits and Heart	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2556	Brazilian Fruits and Heart	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual Paulista - Câmpus de Marília	Universidade Estadual Paulista - Câmpus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-9cvrrs	<NULL>	"Young adult men from 18 to 30 years;
Apparently healthy; active according to the IPAQ and BMI 18,5 e 29,99 kg/m2"	Individuals with cardiorespiratory; neurological; musculoskeletal; renal; metabolic; endocrine or other reported impairments will not be analyzed to prevent them from performing the procedures; individuals with SBP&gt; 130mmHg and DBP&gt; 90mmHg at rest; smokers; alcoholics; those who are under medication that influence the autonomic nervous system; sedentary and insufficiently active according to the IPAQ.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-8r8b6p	Virtual Game for teaching drug preparation and administration	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2557	Virtual Learning Technology for teaching drug  preparation and administration	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8r8b6p	<NULL>	Students enrolled regularly in the university&apos;s nursing course, at semiology, semi-technical and caregiving subject.	Students who have had some personal or professional practice related to preparation and administration of drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-9nbfsf	Postoperative evaluation of lasting procedures after Laser application in the donor area: a Randomized Clinical Test	Not yet recruiting	Intervention	2019-03-28	<NULL>	<NULL>	2560	Morbidity postoperarive procedures in Tissue Graft after Laser application of Low Power in donor area: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-30	Faculdade de Odontologia UFRGS	Faculdade de Odontologia UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-9nbfsf	<NULL>	The following inclusion criteria will be applied when patients are selected: age greater than 18 years; patients requiring connective tissue grafting; systemically healthy patients, without any condition that may influence healing, including but not restricted to decompensated and / or immunodepressed diabetics and coagulation disorders; no smokers or former smokers for at least one year; patients who do not require preoperative antibiotic prophylaxis	During the course of the study the following exclusion criteria will be considered: patients who develop systemic conditions that interfere in healing; patients who start smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-8rpmcg	Body Composition and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2573	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8rpmcg	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:48
RBR-46ttz5	Renal Function and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2574	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-46ttz5	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-76gtyz	The influence of proprioceptive insoles associated with acupuncture in women	Not yet recruiting	Intervention	2019-04-01	<NULL>	<NULL>	2576	The influence of acupuncture-associated proprioceptive insoles on balance, posture, muscle activity, flexibility and energy profile of meridians in women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-25	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-76gtyz	<NULL>	University students, female; age between 18-30 years; sedentar;have access to Whatsapp; application for smartphones; in order to facilitate the communication.	Students who present S scoliosis; uncorrected vestibular; auditory and ocular alterations; recent fractures in the lower limb; prosthesis in the lower limb; pregnant women; BMI&gt; 25.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-8kkh26	Dance Program for Older Adults	Not yet recruiting	Intervention	2019-01-03	<NULL>	<NULL>	2578	Effects of Dancing on Physical-Functional Fitness, Cardiometabolic Profile, Cognition and Quality of Life of Older Adults: a Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Hospital Universitário Onofre Lopes – HUOL	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-8kkh26	<NULL>	Both sexes; age equal or superior to 60 years; fit for physical exercise; pharmacological plan unchanged in the last 4 weeks; agreeing to participate in any of the groups; not participating in a regular exercise program in the last 3 months	Not signing the consent term; history of cardiovascular diseases or events; limiting chronic lung disease; chronic kidney disease requiring dialysis; uncontrolled hypertension; diabetes in use of insulin or decompensated; high alcohol consumption; uncorrected limitations of language, hearing or sight; contraindication for exercise, shown in the cardiopulmonary exercise test; cognitive impairment according to the MEEM and/or RAVLT tests; progressive neurological disorders; cancer requiring treatment in the last two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-8zzfzn	Evaluation of efficacy and safety of Penetro solution for inhalation (eucalyptol, terpin monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in adults	Not yet recruiting	Intervention	2019-04-02	<NULL>	<NULL>	2579	Evaluation of superiority on efficacy and safety of Penetro solution for inhalation (eucalyptol, terpin monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in adult population: a phase III, national, multicenter, double blind and randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-07-01	CAEP - Centro Avançado de Estudos e Pesquisas	Synova Pesquisa Científica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-8zzfzn	<NULL>	Men or women between and including 18 and 65 years-old; women of childbearing age willing or able to use, at least, one highly effective contraceptive method throughout the study. In the context of this study, an effective method is defined as one that results in a low failure rate (i.e. less than 1% per year) when used consistently and correctly such as barrier methods, oral, injectables or implanted contraceptives, sexual abstinence or vasectomy of the partner; participants able to understand and perform all study procedures and instructions; participants who signed the Informed Consent Form (ICF) prior to any procedures regarding the study; participants diagnosed with moderate or severe nasal obstruction (i.e. at least number 5 of VAS - Visual Analogue Scale) due to cold or flu and who present symptoms within 24 to 48 hours after the onset of these symptoms.	Hypersensitivity to any of the components, including active ingredients, regarding the study medication; people that have used the study medication (Penetro) at previous time; total obstruction of one nostril by other etiologies that are not related to cold or flu, or for a period less than 24 hours and greater than 48 hours after the onset of symptoms; infectious processes of bacterial etiology (clinically diagnosed); participants on antibiotic treatment or being about to start an antibiotic therapy for another clinical condition; use of intranasal corticosteroid (7 days prior to the study) or systemic (15 days prior to the study), respecting the plasmatic half-life of the drug; use of intranasal or systemic decongestants or antihistamines in the 3 days prior to the study; participants taking inhaled or immunosuppressive drugs 7 days prior to the study; participants with nasal septum deviations (grades II and III), nasal polyps, pronounced hypertrophy of turbinates, hypertrophy of adenoids or other conditions determining nasal obstruction; use of a chronic oral respirator for 6 months or more before inclusion in the study; history of alcohol and/or drug abuse 3 months prior to the study, confirmed after a questioning done by the investigator; history of surgery in the 3 months prior to the study; being a smoker; female participants of childbearing age with a positive pregnancy test on the urine test; participation in a clinical study in the last 12 months; other diseases that, at the discretion of the principal investigator, may interfere with the results of the study; participants with known mental incapacity, language barriers or any incapacity that, at the discretion of the principal investigator, prevent the correct understanding of the Informed Consent Form (ICF) and study activities; known clinically significant systemic disease; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-4ntszb	Hypertension and exercise: an intervention study in older patients	Not yet recruiting	Intervention	2019-04-02	<NULL>	<NULL>	2580	Effect of high-intensity interval training and moderate-intensity continuous training on ambulatory blood pressure, cardiac, vascular, autonomic, cerebral, psychological, metabolic and body composition outcomes in hypertensive older adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Rio Grande do Norte – UFRN	Hospital Universitário Onofre Lopes – HUOL	https://ensaiosclinicos.gov.br/rg/RBR-4ntszb	<NULL>	Both sexes; aged 60-80 years; previous diagnosis of hypertension; self-reported and clinically assessed physical activity readiness; unchanged pharmacological plan for hypertension in the last 4 weeks; willing to engage in any of the interventions; not engaging in a regular physical activity program in the past 3 months; insufficiently active (i.e., not performing 150 min/week of moderate physical activity and/or 75 min/week of vigorous physical activity, assessed through 7-day accelerometry)	Being unable or refusing to sign the consent form; previous cardiovascular events or diseases (e.g. unstable angina, severe arrhythmia, acute myocardial infarction, coronary artery disease, stroke, deep vein thrombosis, peripheral artery disease, uncontrolled arrhythmia, pacemaker use, etc.); limiting chronic pulmonary disease (emphysema, chronic bronchitis, asthma); chronic kidney disease in need of dialysis; incidence of cardiovascular or pulmonary events during the study; uncontrolled hypertension (&gt; 160/105 mmHg); diabetes with insulin use or decompensated (fasting glucose &gt; 300 mg/dl); high alcohol intake (&gt;14 doses per week); self-reported or perceived language, hearing or sight limitations that may come to hinder participation; exercise contraindication, as indicated on the maximum cardiopulmonary exercise test (e.g. EKG alterations suggesting myocardial ischemia); osteomioarticular issues that may prevent performing maximal cardiopulmonary exercise testing and moderate-to-vigorous aerobic exercise or osteomioarticular injury during the study (e.g. muscle injury resulting in limitations for exercise); neurological progressive disorders (Parkinson, multiple sclerosis, Alzheimer); cancer demanding treatment in the past two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-7dmd7k	Development of a mobile application to apply questionnaires on diseases in the knees	Not yet recruiting	Intervention	2019-04-03	<NULL>	<NULL>	2583	Development and validation of knee questionnaires: an application for the evaluation of knee injuries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-18	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO	https://ensaiosclinicos.gov.br/rg/RBR-7dmd7k	<NULL>	"Age over 65 years;
diagnosis of osteoarthritis of the knee using the criteria for osteoarthritis of the knee of the American College of Rheumatology (ACR, 1986) or to have grade II or III knee osteoarthritis of the Kelgren and Lawrence (KL) scale;
walking independently, without support device;
being for at least six months without practicing resisted physical exercise;
and do not present as follows:
any congenital, traumatic, infectious or deformity abnormality following injury to the knee joint that may have contributed to the development of secondary OA;
inflammatory arthritis (e.g., Rheumatoid Arthritis);
grade IV knee osteoarthritis on the KL scale;
knee flexion deformity greater than 15 degrees;
inability to walk or walk with the aid of devices;
neurological problems;
neuromuscular disease or injury;
surgery on the knee (s) in the last year;
corticosteroid injection in the last three months;
uncontrolled hypertension (&gt; 150/90 mmHg);
myocardial infarction in the last six months;
unstable cardiovascular disease;
conditions that may be exacerbated by the protocol (e.g., unstable angina);
fractures within the six-month period; present painful changes in the hips and / or ankles and / or pain in the lower back; or severe comorbidity that limits participation in the study.
Clinical guidelines established by the ACR include having knee pain on most days of the month and at least 3 of the following 6 criteria: age 50 and older, joint stiffness lasting 30 minutes, crepitation, bone sensitivity, bone augmentation, and heat palpable."	"Not participating in one of the sessions;
Any limitation that impedes the continuity of the participant in the study;
Participants with BMI&gt; 30 kg / m2 (minimize artifact at EMG)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:49
RBR-2bsfm4	Effect of circuit exercises on muscular strength, balance and mood	Not yet recruiting	Intervention	2019-04-12	<NULL>	<NULL>	2596	Impact of a circuit exercise program on the physical-function capacity, on the risk of falls and depressive symptoms int he community-dwelling elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-2bsfm4	<NULL>	Minimum age of 60 years; reside in the community; inactive; with a history of falls and/or risk of falling; not be participating in other research.	Bedridden or wheelchair-bound situation; motion dependent aid device; cognitive deficit; severe visual impairment; amputations or use of lower limb prosthesis; history of recent fracture of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-4m5j4s	Non-Invasive Brain Stimulation Associated with Aerobic Exercise: Repercussions on Pain, Memory, and Sleep of Individuals with Chronic Migraine	Not yet recruiting	Intervention	2019-04-16	<NULL>	<NULL>	2601	Repetitive Transcranial Magnetic Stimulation associated with Aerobic Exercise: Repercussions on Perception of Pain, Memory and Sleep/Wake Rhythm of Individuals with Chronic Migraine	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-22	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4m5j4s	<NULL>	Individuals of both sexes between the ages of 18 and 65 who present a clinical diagnosis of chronic migraine.	Individuals with: History of seizure; Lesions in the region of the skull and/or cervical spine, as well as in the process of soft tissue healing; Presence of other neurological diseases or psychiatric disorders; Use of metal prostheses (excluding buccal cavity) or cardiac pacemaker; Pregnancy; Individuals contraindicated for the proposed aerobic exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-7b2dyj	Muscular Strength and Kidney Transplantation: comparison between blood flow restriction resistance training and traditional resistance training.	Not yet recruiting	Intervention	2019-04-17	<NULL>	<NULL>	2606	Blood Flow Restriction Resistance Training in Kidney Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-30	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-7b2dyj	<NULL>	The patient should be aged between 20 and 59 years old; to be a kidney transplantation patient for at least six months; the patients should be attended in University Hospital of Federal University of Maranhão; have a medical record number; systolic and diastolic blood pressure lower than 180 mmHg and 110 mmHg, respectively; serum hemoglobin greater than 9 g / dL; glycated hemoglobin (HbAlc) less than 11 percent; and to be able to practice physical exercise through release of responsible nephrologist medical.	Presence of chronic obstructive pulmonary disease; congestive heart failure; active coronary disease; recent acute myocardial infarction; and / or patients with some contraindication to performing physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-5mhjq5	Promoting preventive intentions in Leprosy with school adolescents	Not yet recruiting	Intervention	2019-03-07	<NULL>	<NULL>	2611	Cultural circles: promoting preventive intentions in Leprosy with school adolescents	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5mhjq5	<NULL>	"School adolescents, students of public schools in the city of Recife;
Age between 12 and 18 years;
To attend elementary school in the 7th year
Residing in the Political-administrative Regions: II, IV or VI;
Accept freely to participate in data collection through the questionnaire response"	Adolescents with special physical or mental condition, who present difficulties in understanding the questions of the instrument of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-9d8ryw	Effect of manual therapy of the vagus nerve on pain and thoracic expansion in patients with neck pain	Not yet recruiting	Intervention	2019-04-22	<NULL>	<NULL>	2615	Effect of manual therapy of the vagus nerve on pain and thoracic expansion in patients with chronic non-specific neck pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Centro Universitário União das Américas - UNIAMÉRICA	Centro Universitário União das Américas - UNIAMÉRICA	https://ensaiosclinicos.gov.br/rg/RBR-9d8ryw	<NULL>	Aged between 18and 65 years; body mass index (BMI) &lt;30 kg / m², with neck pain for a period equal or greater than 3 months; a Portuguese-Brazilian version of the Neck Disability Index (NDI) score of 5 or higher and a Numeric Rating Scale (NRS) score of 3 or higher at rest or during active neck movement. The participant must be willing to participate in the study and sign the Informed Consent Term.	Participants are excluded if they had: bone diseases; bone fracture; history of tumor or cancer; cervical whiplash injury; history of neck trauma; previous spine surgery; have undergone physiotherapeutic or medical treatment for neck pain in the last 3 months prior to the study; using analgesic, anti-inflammatory and muscle relaxant medications during the week prior to the study; use of medications that could alter cardiac autonomic activity, such as (propranolol and atropine); systemic diseases; diagnosed fibromyalgia; diagnosed cardiovascular disease; orofacial pain; pregnancy; cervical radiculopathy; smoking; ethyl alcohol; diagnosed respiratory disease; diagnosed neuromuscular disease; and inability to perform the tests and answer the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-3pgyyq	prospective randomized study in the use of pregabalin for control and prevention of chronic pain after inguinal hernioplasty	Not yet recruiting	Observational	2019-04-22	<NULL>	<NULL>	2618	prospective randomized study in the use of pregabalin for control and prevention of chronic pain after inguinal hernioplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	universidade de santo amaro	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-3pgyyq	<NULL>	Male patients, aged between 18 and 60 years, with primary unilateral inguinal hernia, without comorbidities	Patients on non-hormonal anti-inflammatory or corticosteroid use prior to surgery, discontinuation of medication use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:50
RBR-42whhj	Stair climb task training after stroke: a feasibility study	Not yet recruiting	Intervention	2019-04-24	<NULL>	<NULL>	2629	Elliptical training on improvement of stair ascent capacity of individuals with hemiparesis in the chronic phase: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-22	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-42whhj	<NULL>	As criteria for inclusion are indicated: individuals who had the BIRD for more than 18 months; residents in the community; able to provide consent, criterion set to showing the final score on the Mini Mental State examination of 13 to 18 for illiterates, low/middle education, and 26 for high Education; are over 20 years old; are able to climb ladder with or without help of auxiliary devices of March for at least 4 steps with comfortable speed. Score between 4 and 6 in MIF rating scale (M-Locomotion: Stairs); submit a medical certificate to be able to physical activity	As exclusion criteria: some unstable heart condition that can restrict your participation in a moderate exercise program (i.e. not considered suitable by the physician in charge); cognitive deficits and/or of language (aphasia of comprehension) severe when asked to answer commands simple engines, which can restrict your answer to follow instructions during the data collection and/or intervention; other relevant medical conditions that may affect your ability to walk, as vestibular disorders, severe osteoarthritis or other neurological conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-9v3q33	Loss urinary treatment with heat waves and pelvic floor exercises.	Not yet recruiting	Intervention	2019-04-25	<NULL>	<NULL>	2631	Fractional Microablative Radiofrequency and Pelvic Floor Muscle Trainng in the treatment of women with Stress Urinary Incontinence: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Faculdade de Cienciena Médicas da Universidade Estadual de Campinas (UNICAMP)	Faculdade de Cienciena Médicas da Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-9v3q33	<NULL>	Women between 45 and 65 years of age with symptoms of stress urinary incontinence and mixed urinary incontinence with predominance of the stress component identified through anamnesis and with availability to attend the therapies at the date and places scheduled for the proposed treatment.	Use of pacemaker; presence of genital prolapses stages III and IV; decompensated heart disease; cognitive deficit; peripheral or central neurological disorders; presence of any type of cancer; presence of cervical dysplasia; history of active urinary tract or vaginal tract infection; decompensated metabolic diseases; physiotherapeutic treatment with previous pelvic floor training in the last 12 months; use of estrogen via the vagina in the last 6 months; current use or in the last 6 months of oral hormone replacement therapy; patient already undergoing prolapse correction or sliding surgeries. presence of intrauterine device; MAP shrinkage force equal to zero according to the Oxford Modified Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-86c6jp	Evaluation of the effect of the school&apos;s prevention program Elos to aggressiveness	Not yet recruiting	Intervention	2019-04-26	<NULL>	<NULL>	2637	Evaluation of the effectiveness of the program Elos-Building Collectives to reduce aggression in children from 1st to 4th year of elementary school	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-03-30	Universidade Federal de São Paulo	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-86c6jp	<NULL>	Be a student enrolled in the 1st to 4th. year of public schools selected randomly from the INEP list, and consent to answer the questionnaire of pre and post test.	Questionnaires without adequate codes; Refusal in completing the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:51
RBR-7gm9zh	Effectiveness of Mindfulness as an adjunct to treatment in Therapeutic Communities.	Not yet recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2646	Effectiveness of Mindfulness Based Relapse Prevention  as an adjunct to the treatment of substance use disorder: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-17	Universidade Federal de São Paulo UNIFESP	Fundação de Amparo a Pesquisa de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-7gm9zh	<NULL>	Men and women over 18 years of age who are literate (with ability to write and read in Portuguese); who have been on treatment for UUS in one of the services for at least fifteen days; who have consented to be randomized to one of the two groups (control or experimental) .	Patients with psychotic disorders diagnosed by the physician responsible for the services participating in the research or informed by the team for clinical knowledge prior to the patient&apos;s hospitalization; who present severe cognitive impairment that prevents the completion of the scales; patients with suicidal ideation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-29q75w	Benefits of an intervention with the use of an educational handbook in the support provided by caregivers in the delivery room	Not yet recruiting	Intervention	2019-05-01	<NULL>	<NULL>	2648	Effectiveness of intervention applied in maternity with use educational manual in the support provided by chaperone in delivery room	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-06	Departamento de Enfermagem - Universidade Federal do Ceará	Maternidade Escola Assis Chateaubriand (MEAC)	https://ensaiosclinicos.gov.br/rg/RBR-29q75w	<NULL>	"The study population will be composed of two target groups: accompanying parturients who were admitted to the Maternity Center of the Maternity School Assis Chateaubriand (MEAC), between June and November of 2019; and puerperal women who have their companions involved in this research.
The population will be divided into two groups:
CONTROL GROUP (CG): group of accompanying persons eligible to participate in the research that will receive the routine guidelines, that is, guidelines performed in the delivery room by health professionals, academics, among others; as well as puerperal women who have their companions involved in this group. Thus, part of this group will be the puerperae and their respective participants who do not receive the educational intervention proposed by the researcher.
INTERVENTION GROUP (GI): group of companions to whom an intervention will be carried out using the educational manual; For this, after the accompanying person is authorized by the MEAC social service to accompany the delivery at the Obstetric Center; he will be invited to participate in the study and, if so, the educational intervention will be applied.
The joint reading of the manual has an average duration of twenty minutes, being interrupted to clarify doubts and questions made by the companion.

During the intervention, it will be agreed with the companion not to make the manual available to other people, clarifying the justifications for this fact.
The selection of the sample will follow the following inclusion criteria: be accompanying the choice of the woman patient; be accompanying nulliparas; have completed at least the fourth year of elementary school (level of education compatible with the readability index of Flash calculated for the manual evaluated here); as well as puerperal women who have companions with this profile; will also include all the puerperas who had, during the birthing process, the presence of companions who participated in this research in both groups."	"The exclusion criteria will be: to present a state of physical or mental health compromised in order to make data collection unfeasible; have previous experience of witnessing delivery as a companion; participate in another intervention in the institution (Ex.:Roda de Conversa)

The criteria for discontinuity will be: to accompany a parturient referred for cesarean section; give up participating in the study after the start of the collection; give up or be unable to follow labor / delivery; change of address and / or telephone that makes the contact unfeasible after the birth, if the only way to establish communication with the participant is by telephone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-8zgtmd	"Evaluation of efficacy and safety of Penetro® solution for inhalation (eucalyptol, terpin
monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in 06-17 years-old children"	Not yet recruiting	Intervention	2019-05-02	<NULL>	<NULL>	2652	Evaluation of superiority on efficacy and safety of Penetro® solution for inhalation (eucalyptol, terpin monohydrate and menthol) over placebo in the treatment of acute nasal obstruction in pediatric population 06-17 years old: a phase III, national, multicenter, double blind and randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-07-01	Centro de Pesquisa Clínica São Lucas	Synova Pesquisa Científica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-8zgtmd	<NULL>	Participants greater than or equal to 06 and less than or equal to 17 years of age; Participant with symptoms of moderate or severe nasal congestion (ie, reaching at least 5 VAS) lasting at least 24 hours and a maximum of 48 hours prior to inclusion; Negative urinary B-HCG test for female participants after menarche; Participants able to understand and perform all study procedures and instructions; Participants must have the Informed Assent Form and the Informed Consent Form prior to any procedures related to the study.	Hypersensitivity to the active ingredients of study medication; Have used the study drug (Penetro®) at some earlier time; Total obstruction of one nostril by other etiologies that are not cooled or influenza, or for a period less than 24 hours and greater than 48 hours after the onset of symptoms; Bacterial Infectious etiology (diagnosed clinically); Participants on antibiotic treatment or anticipation of antibiotic use for another clinical condition; Intranasal corticosteroid use (7 days before study) or systemic (15 days before study), respecting the plasma half-life of the drug; Use of decongestants or intranasal or systemic antihistamines in the 3 days prior to the study; Participants taking inhaled or immunosuppressive drugs 7 days before the start of the study; Participants with grade II and III septum diversion, nasal polyps, severe congenital hypertrophy, adenoid hypertrophy, or other conditions that determine nasal obstruction; Chronic oral respirator with history for 6 months or more prior to study inclusion; History of surgery in the 3 months prior to the study; Female participants with a positive pregnancy outcome through the urinary hCG test; Participation in a clinical trial in the past 12 months; Other diseases that, at the discretion of the researcher responsible, may interfere with the results of the study; Mental incapacity or linguistic barriers or incapacity that, in the discretion of the researcher responsible, prevent the adequate understanding of the information of the Term of the Free and Informed Assent and the Informed Consent Form and the activities of the study; Known clinically significant systemic disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-7zphsf	Effects of Evaluation of Exercise Capacity at the level of daily physical activities of adults of the community	Not yet recruiting	Intervention	2019-05-06	<NULL>	<NULL>	2659	Effects of the Avaluation of Cardiorrespiratory Fitness at the level of activity and physical fitness of adults of the community	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal São Paulo	Universidade Federal São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zphsf	<NULL>	Age from 18 years; without diagnosis of cardiorespiratory, metabolic or neuromuscular diseases that prevent the performance of physical exercises	Basal cardiorespiratory fitness greater than 9 METs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:52
RBR-4yht9x	Effect of a Planned Exercise Program on Physical Values and Quality of Life in Women with Breast Cancer Performing Neoadjuvant Chemotherapy	Not yet recruiting	Intervention	2019-05-23	<NULL>	<NULL>	2669	Effectiveness of a Structured Physical Exercise Oriented Program on Strength, Cardiorespiratory Fitness and Quality of Life in Women with Breast Cancer Submitted to Neoadjuvant Chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Departamento de Nutrição da Universidade Federal do Rio Grande do Norte - UFRN	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-4yht9x	<NULL>	Adult individuals; women; sedentary; age between 20 and 59 years; diagnosed with breast cancer; computed tomography scan of the abdominal region available on your chart; did not perform the first cycle of neoadjuvant chemotherapy.	Patients with metastatic disease; symptomatic cardiac or pulmonary disease; psychiatric; with intellectual physical incapacity to understand the stages of the research; in vulnerability to consent their participation or that do not obtain release of the oncologist to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:42
RBR-3bskgt	The influence of meditation focusing on breathing in the anxiety in LGBT	Not yet recruiting	Intervention	2018-10-03	<NULL>	<NULL>	2673	The influence of meditation practice focusing on breathing in the signs and symptoms of anxiety in the LGBT population	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-15	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3bskgt	<NULL>	"The criteria for inclusion for students participating in the meditation group is older than 18 years, be student of UFAL (Federal University of Alagoas) and LGBT; be showing signs and symptoms of anxiety through MINI (MINI International Neuropsychiatric Interview) and/or IDATE (State trait anxiety inventory).
For the control group, the inclusion criteria will be the same."	"Will be deleted the students who refuse to participate in the study; who have more than one absence per month in the meditation; those who do not fulfil the daily meditation and those who give up graduation during meditation practice.
For the control group, the exclusion criteria will be the same."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-5bch9m	Effect of the use of cellular application for adhesion to treatment of adolescents with Diabetes Mellitus 1	Not yet recruiting	Intervention	2019-06-03	<NULL>	<NULL>	2674	Effectiveness of a mobile application for the clinical and educationalcare for adhesion to treatment of adolescents with Diabetes Mellitus 1: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-05	Eline Saraiva Silveira Araújo	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5bch9m	<NULL>	The population will be comprised of adolescents between 12 and 17 years old; with DM1 in follow-up at the Integrated Center for Diabetes and Hypertension (ICDH).	Those who do not appear during the data collection period or who do not have a smartphone and / or mobile internet will be excluded. There may be losses due to death or a change in the service location.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-42v548	Treatment by low level LASER in the roof of the mouth in patients with snoring and sleep apnea	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2684	Photobiomodulation by low level LASER therapy in patients with obstructive sleep apnea	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-42v548	<NULL>	Score in two or more positive categories in the Berlin Questionnaire; when performing the polysomnography examination, the apnea and hypopnea index should be greater than or equal to 15 events per hour of sleep (AHI&gt; 15 / h).	Pediatric, eudaphic and elderly patients; patients with diagnosed central apnea; alcoholic patients, smokers, oncologists, pneumopathies, patients with heart disease and with hypothyroidism; pregnant women; or patients with a history of photosensitivity (allergic). Participants unable to understand and sign the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9gnkr2	Impact of low electrical stimulation on the scalp and physical training on the adaptations of the system that regulates body functions in patients with weakness on one side of the body resulting from a stroke.	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2685	Impact of Transcranial Direct Current Stimulation and physical training on the autonomic adaptations in hemiparetic patients due to the Stroke: Clinical Trial, Controlled, Randomized, Double-blinded	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-08	UNINOVE	CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9gnkr2	<NULL>	To present hemiparesis due to stroke for more than 6 months; Mild or moderate motor impairment determined by the Fugl-Meyer test with lower limb scores between 20 and 31 points; Comfortable walking speed in the ground between 0.3 and 1.15 m / s; Classification between levels 04 to 06 in Functional Mobility Scale (FMS) - Functional Mobility Scale and ability to perform exercise on the bicycle; Presentation of AVC provings; Signature of science regarding the term of free and informed consent (TCLE); Blood test (hematological and biochemical); Image examination of lesion location; The use of beta blockers will not be considered an exclusion factor due to the large percentage of patients taking this drug, a separate analysis will be performed to see if there are baseline differences in the other patients.	To present cognitive deficits in the Mini Mental State Examination (MMSE) with scores below 17 points; Visual impairment that may interfere with the performance of the tests; Severe cardiac problems (congestive heart failure, angina, peripheral vascular disease), use of pacemaker; Contraindications to the use of CTEE (brain implant of metal clips near the area to be stimulated, history of recurrent seizure, recurrent epilepsy and brain tumors, cerebral pacemaker, bore or cracks in the cranial cavity, cutaneous lesions near the area to be stimulated and / or metal plates or devices at the ETCC stimulation site); Irregular menstrual cycle or being in the menstrual period during the evaluation; No medical certificate for the aerobic exercise test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:53
RBR-9wddjb	Physiotherapeutic evaluation of pregnant women practicing Pilates	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2686	Cardiorespiratory, musculoskeletal and aesthetic evaluation of pregnant women practicing the Pilates method	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-9wddjb	<NULL>	Medical authorization containing release for the practice of exercises; physiological gestation with a live fetus; gestational age above 16 weeks; physiological puerperium.	chronic-degenerative diseases; high-risk gestation; presence of any pregnancy-related pathology (polyhydramnios, pregnancy-induced hypertension (HAIG); previously diagnosed or any contraindication to physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-9tvfk2	"Effect of GPR 
on rehabilitation  and sleep after stroke"	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2688	"Effect of Global Posture Reeducation 
on rehabilitation  and sleep after stroke"	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2019-03-20	Fundação de Amparo à Pesquisa do estado de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9tvfk2	<NULL>	Patients of both sexes, with age greater than or equal to 18 years of age; Patients with Apnea and Hypopnea Index ? 15;  Patients with a history suggestive of a first acute stroke will be invited or may apply to participate in the study; Subacute stage of stroke (between 30 days and 3 months after disease onset); Magnetic Nuclear Resonance or Computed Tomography of the brain performed after hospital admission demonstrating ischemic or hemorrhagic stroke; Patients with NIHSS scores for stroke between 5 and 20 (moderate to moderate / severe stroke-motor impairment) at the time of entry study evaluation; Availability of attendance at physical therapy and assessment sessions; Accept in participating in the study and signing the Informed Consent Term (TCLE).	Patients with other associated neurological or sleep disorders that interfere with rehabilitation;Patients with renal insufficiency; Previous presence of stroke, subarachnoid hemorrhage or due to secondary cause, malformation, vasculitis, brain tumor or head trauma; Use of potent sedative drugs or continuous sedation; Patients with associated restrictive pulmonary or peripheral vascular diseases; Patients with congestive heart failure or class III or IV heart failure of the New York Heart Association Functional Classification; Non-cooperative patients due to lowering of level of consciousness, impairment of language, vision or important cognitive (verified by Montreal Cognitive Assessment (MoCA, Simões et al, 2008); Previous sleep breathing disorders under treatment; Patients who miss physical therapy sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-55zbhb	Influence of osteopathic treatment on the autonomic nervous system of patients with chronic low back pain	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2690	Effects of osteopathic manipulative treatment on the neurovegetative system of patients with chronic low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Renan Omil Pravatta Pivetta	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-55zbhb	<NULL>	Age between 18 and 65 years of age; low back pain on most days for at least 3 months with numeric scale of pain greater than 3.	Upper motor neuron alterations; severe osteoporosis; progressive neurological deficit; positive Laségue test below 35 °; inability to complete the questionnaires; previous lumbar surgery; autoimmune diseases; neoplasms; pregnancy or withdrawal by the INSS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-7wxsqv	Reference values for oxygen supply levels and use of Near_Infrared Spectroscopy (NIRS) in individuals with Diabetes	Not yet recruiting	Intervention	2019-06-04	<NULL>	<NULL>	2701	Reference values for tissue perfusion levels and use of Near-Infrared Spectroscopy (NIRS) in individuals with Diabetes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Minas Gerais	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-7wxsqv	<NULL>	Individuals of both sexes will be included; type 2 diabetics; above 18 years of age; that do not have any musculoskeletal changes or comorbidity that impedes the physical effort of the proposed stress test; and who present the medical release to participate in the study.	Individuals with an inability to understand or perform any proposed test will be excluded from the sample, those with an ankle-brachial index (ABI) of less than 0.90 or greater than 1.40 and those who withdraw their consent to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:54
RBR-3bf686	Effect of adhesive strategy and different photoactivation times of a universal adhesive system on the longevity of composite resin restorations in patients with dental lesions near the gingiva.	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2709	Effect of adhesive strategy and different photoactivation protocols of a universal adhesive system on the longevity of composite resin restorations in patients with non-carious cervical lesions [LCNC] . Double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3bf686	<NULL>	Patients older than 18 years will be included; Presence of at least two LCNC per patient regardless of their location in the dental arch; With a need for restorative treatment; Adequate oral hygiene; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; LCNC with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the survey; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-88ykxm	Evaluation of the safety of products for health by doctors dermatologist and gynecologist under normal conditions of use	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2710	Evaluation of the gynecological and dermatological capacity of health products under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-21	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-88ykxm	<NULL>	Women. Age: 18 to 65 years. Phototype: I to IV. Whole skin of the region. Occasional user of category products	"Cutaneous marks in the experimental area that interfere in the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scarring, increased hairiness, ephelides and nevus in large quantities, sunburns). Pregnant or nursing mothers. Participants with a history of allergy to the material used in the study. History of atopy. Use of vaginal cream.Participants with a history of allergy to cosmetic products of the category tested. Recent gynecological surgeries. Corrections. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Active cutaneous pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis). Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.
Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-87dkhg	Thigh muscle strengthening associated with a therapeutic electrical stimulation compared to an isolated thigh muscle strengthening in subjects with atraumatic patellar dislocation	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2711	Quadriceps strengthening associated with neuromuscular electrical stimulation versus quadriceps strengthening alone to the treatment of atraumatic patellar dislocation: A blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-13	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-87dkhg	<NULL>	"Inclusion criteria: 
Individuals aged between 16-40 years, of both sexes, with a history of at least one episode of atraumatic patellar dislocation requiring emergency care. The participants should present with apprehension to the lateralisation of the patella, pain to the palpation of medial retinaculum and J-sign to the flexion and extension of the knee."	"Exclusion criteria: 
Individuals who are using knee imobilisation, crutches and those with restricted knee range of movement that prevents the realisation of the exercises protocol during the recruitment period. 
Individuals with a history of traumatic patellar dislocation, previous surgical treatment for patellar dislocation, those with a history of other ligaments (ACL, PCL, LCL or MCL) or meniscal injuries and those with a history of previous surgery on the lower limbs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-74hk74	Assessment of the safety of a dental product	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2712	Evaluation of dental acceptability of product with appreciability for health under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-21	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-74hk74	<NULL>	Age: 18 to 65 years. Female and male. Phototypes: I to IV. Healthy mouth except for oral affection (cold sore). Perform brushing at least 3 times a day	"Active dermatoses (local and disseminated) that may interfere with the results of the study. Screening or nursing. Allergy or reactivity for the category of tested products. Participants with a history of allergy to the material used in the study. History of atopy. Immunodeficiency carriers. Renal, cardiac or hepatic transplanted. Use of the following topical systemic medicinal products: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection. Abnormality or symptom in the region. Diabetes. Use of orthodontic appliance. Prediction of vaccination during the study or up to 03 weeks before the study. Be participating in another study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. Have performed or performed oral surgeries during the study. History of lack of adherence or unwillingness to adhere to the study protocol;
Professionals directly involved in the realization of this protocol and their relatives."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-3znpr6	Assessment of the safety of a dental product	Not yet recruiting	Intervention	2019-06-05	<NULL>	<NULL>	2716	Evaluation of the dental acceptability of the product for health under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-20	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-3znpr6	<NULL>	Age: 18 to 65 years. Female and male. Phototypes: I to IV. Healthy mouth except for oral affection (cold sore). Perform brushing at least 3 times a day	Active dermatoses (local and disseminated) that may interfere with the study results. Pregnant or nursing mothers. Allergy or reactivity for the category of tested products. Participants with a history of allergy to the material used in the study. History of atopia.Portadores de inmunodeficiencias.Transplanted renal, cardiac or hepatic. Use of the following systemic topical medications: immunosuppressants, antihistamines, non-hormonal anti-inflammatories, and corticosteroids up to two weeks prior to selection. Abnormality or symptom in the region. Diabetes. Use of orthodontic appliance. Prediction of vaccination during the study or up to 03 weeks before the study. Be participating in another study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. Have performed or performed oral surgeries during the study. History of absence of adherence or unwillingness to adhere to the study protocol. Professionals directly involved in the realization of this protocol and their relatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-5r93wn	Comparison of the effect and toxicity between two options for the treatment of Mucosal Leishmaniasis: Miltefosin and Liposomal Anfotericin B	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	2719	Efficacy and safety of Miltefosin in comparison with Liposomal Anfotericin B for the treatment of Leishmaniasis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2018-03-01	Centro de Pesquisa Rene Rachou, Fundação Oswaldo Cruz	Hospital Universitário Julio Muller	https://ensaiosclinicos.gov.br/rg/RBR-5r93wn	<NULL>	Both sexes; age greater than 18 years; mucosal impairment; parasitological confirmation of Leishmania infection by one or more of the following methods: parasitological examination (direct examination or culture), histopathology, immunohistochemistry or molecular test; consentiment form signed; availability for the schedule of the study	Women in reproductive age with positive (serum) pregnancy test at the time of screening; or lactating women; or women who can not or will not use contraception during and for up to 3 months after discontinuation of treatment; Carriers of HIV infection or other immunodebilitating condition; hepatic enzimes levels 3 times above the upper limit of normal, according to reference values; previous treatment for LM in the 6 months prior to study inclusion; previous treatment with leishmanicidal drugs indicated for the treatment of other diseases in the last six months prior to inclusion;use of medications that interfere with the therapeutic response or that cause interactions with drug of the study;  A history of hypersensitivity to the drugs being tested; renal, cardiac, hepatic or psychiatric disease that at the discretion of the investigator represents a contraindication to the use of some of the treatment alternatives included in this study; disseminated leishmaniasis concomitant with mucosal involvement; intravenous drug users or other chemical dependencies; Sjogren-Larson syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:55
RBR-9qm3x9	Influence of an educational video to improve Vaccination against human papillomavirus	Not yet recruiting	Intervention	2019-06-07	<NULL>	<NULL>	2735	Effect of an educational video for adherence to Vaccination against human papillomavirus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9qm3x9	<NULL>	"Schoolchildren: To be a female student, to be nine years old, to be in the fourth year of elementary education in public elementary schools of Sanitary District IV of the city of Recife-PE;
Adolescents: To be a female or male student between the ages of ten and 14, to be in one of the series comprised between the fifth and ninth years of public elementary schools in Sanitary District IV of the city of Recife-PE;
Parents: to be 18 years of age or older, to have a child of age in the vaccination age, to have a child enrolled in public elementary schools in Sanitary District IV of the city of Recife-PE.
In addition, inclusion criteria for schoolchildren and adolescents have not received any dose of the HPV vaccine and, for the parents, have had a child who has not been vaccinated against HPV in order to perform the evaluation of the practice for immunization, evidencing adherence to vaccination."	"Schoolchildren: to be away from school activities due to illness or suspension;
Adolescents: being away from school activities due to illness or suspension;
Parents: have some cognitive limitation that makes it impossible to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-6ws3m6	Evaluation of the Efficacy and Safety of a product for health in burned skin.	Not yet recruiting	Intervention	2019-06-08	<NULL>	<NULL>	2737	Evaluation of a health product for the prevention of burns under normal conditions of use.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Ipclin - Pesquisa Clínica Integrada	Sterifarma Produtos Cirurgicos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-6ws3m6	<NULL>	Age from 18 to 65 years. Gender: male or female. All phototypes. Skin integrity in the test area, selected by the dermatologist, except for possible grade I or II skin burn resulting from radiotherapy. Participants who have given their free and informed consent, are cooperative and aware of the necessity and duration of the controls, so that a perfect adherence to the protocol can be expected. Participants able to read and understand the documents delivered (information leaflet and consent form) and what is explained to them. Participants who agree not to apply any other cosmetic products on the face during the study period, except for the research product and usual hygiene products.	"Pregnancy or lactation;
Pregnancy or lactation. Skinmarks in the test region that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large numbers). Participant with skin problem, in particular: urticaria, edema, eczema, recurrent herpes, herpes zoster occurred in the last 3 months, polycythemia, common acne with onset of nodules or cysts, psoriasis, ichthyosis, lichen planus, lupus, hyperhidrosis. Active dermatoses (local or disseminated) that may interfere with the study results. History of allergic or irritant reactions to topical products: medicines, cosmetics or health correlates of the same category (or other category, but which the investigator considers relevant). History of intense discomfort sensations to topical products: medicines, cosmetics or health correlates of the same category (or other category, but which the researcher considers relevant). Be participating or have participated in another clinical study completed less than 14 days prior to the selection. Any previously unquoted condition which, in the opinion of the investigator, could jeopardize the evaluation of the study;
History of absence of adherence or unwillingness to adhere to the study protocol. Professionals directly involved in the realization of this protocol and their relatives."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-4g2jw3	"Effects of physical activities to control chronic diseases
with blood analysis, work environment and physical inactivity in military police: clinical study"	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2739	"Effects of interventions to control chronic diseases
with biochemical, environmental-occupational and
sedentary behavior in military police: clinical study"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-06	Universidade São Judas Tadeu	Universidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-4g2jw3	<NULL>	To be a military police officer, volunteer, of units: operational and administrative; Male and female; Be in the condition of &quot;active&quot; service; Have at least one year of experience in the Units they serve; Sign the free and informed consent form (TCLE); Have a medical certificate to practice physical activity assessing their clinical state of health to perform interventions with military police.	Police officers working inside the State; Police officers who are already in the paid and retired reservation; Military officers under 25 and over 58; is unable to make interventions for clinical, administrative or judicial purposes within the period specified in the schedule.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-6vpxz6	Assessment of the safety and efficacy of a nasal spray product.	Not yet recruiting	Observational	2019-06-10	<NULL>	<NULL>	2743	Subjective evaluation of the clinical efficacy of a nasal spray.	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Ipclin - Pesquisa Clínica Integrada	Master ind. e com. de produtos odontológicos e farmacêuticos ltda	https://ensaiosclinicos.gov.br/rg/RBR-6vpxz6	<NULL>	"Age: 18 to 65 years
Female and male. Full skin in the study region (nose). Phototypes I to IV. Participants who agree to adhere to the procedures and requirements of the study and to attend the Institution on the days and times determined for the evaluations. Participants who have the capacity to consent to their participation, signing the Informed Consent Term (TCLE). Participants who agree not to use products of the same category during the conduct of this research. Participants who have not participated in similar studies for at least 2 months prior to the study."	"Diseases or medications that may directly interfere with the study or endanger the health of the research participant, according to the physician responsible for including study participants.
Immunodeficiencies. Renal, cardiac or hepatic transplanted. Erythema solar in the study region due to intense sun exposure 1 month before the study. Current use of the following medicines: corticoids, antihistamines, immunosuppressants, retinoids, anti-inflammatories. Participants who refuse to participate in the study in question.
Any condition that could interfere with the evaluations according to the investigator of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-4twg7m	Exercise with ventilation in lung disease.	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2745	Physical training in pulmonary disease with ventilatory support	<NULL>	4, single-arm-study, single-blind	4	<NULL>	<NULL>	<NULL>	2019-08-01	Programa de Pós Graduação em Saude e Desenvolvimento da Região Centro-Oeste, UFMS	Hospital Universitario Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-4twg7m	<NULL>	"Will be included volunteers with at least 35 years of age;
COPD patients according to GOLD II, III and IV criteria;
Free of exacerbation for at least four weeks;
Who are not participating in any pulmonary rehabilitation program."	"Individuals who are unable to perform Cardiopulmonary exercise test on a cycloergometer; 
Are not fit from a cardiovascular and metabolic point of view;
use of beta-blockers; signs of ischemic coronary and / or peripheral disease; uncontrolled diabetes; hypo or hyperthyroidism;  rheumatic or neurological disease; asthma; cognitive deficit; hypercapnic chronic obstructive pulmonary disease, that is, carbon dioxide blood pressure above 50 mmHg in resting arterial blood gases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-6fyzgd	Assessment of the benefits of MASQUELIER&apos;s® Original OPCs within a farmer population highly exposed to pesticides in South Brazil	Not yet recruiting	Intervention	2019-06-10	<NULL>	<NULL>	2746	Double-blind randomized clinical trial assessment of the benefits of MASQUELIER&apos;s Original OPCs within a farmer population highly exposed to pesticides in South Brazil	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-06-07	International Nutrition Company (INC Agency BV)	International Nutrition Company (INC Agency BV)	https://ensaiosclinicos.gov.br/rg/RBR-6fyzgd	<NULL>	It will be included individuals with current agrochemical exposure and with a history of exposure to agrochemicals as a labor activity for at least five years. The selection of farmers has the support of the Department of Health of the Municipality of Santo Amaro da Imperatriz. Another supporting agent will be the Jorge Duprat Figueiredo Foundation for Safety and Occupational Medicine (FUNDACENTRO).	(1) Any dietary supplements with potential effects on antioxidant and inflammatory status are prohibited from 4 weeks before inclusion into this study and during the study period; (2) Any other investigational product is prohibited from 4 weeks before inclusion into this study and during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:56
RBR-9g7kvc	Phone calls follow-up in the care of cancer patients under ambulatorial anti-cancer therapy: randomized clinical test	Not yet recruiting	Intervention	2019-06-14	<NULL>	<NULL>	2763	Telenursing in the care of cancer patients under ambulatorial antineoplastic therapy: randomized clinical test	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-15	Universidade Federal do Ceará	Ambulatório de Quimioterapia do Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-9g7kvc	<NULL>	Patients with diagnose of solid cancers of gastrointestinal tract, breast and lungs, because these represent the majority of people assisted in the referred outpatient care; Patients who are in the first or second chemotherapy cycle; Patients whose age is superior to 18 years old; Patients who scored 15 in Glasgow Coma Scale.	Patients who reached scores inferior to 60%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:57
RBR-89tyds	Evaluation of Effects on Pain through the Use of Lidocaine Adhesive after Cesarean	Not yet recruiting	Intervention	2019-06-19	<NULL>	<NULL>	2774	Evaluation of the Analgesic Effects of 5% Lidocaine Adhesive in Post-operative Cesarean Section: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	Instituto de Saúde Elpídio de Almeida - ISEA	https://ensaiosclinicos.gov.br/rg/RBR-89tyds	<NULL>	Age equal or superior to 18 years; Being submitted to cesarean section under spinal anesthesia; Classification of the American Society of Anesthesiologists 1 or 2.	Patients with a history of intolerance or chronic use of opioids or other medications proposed in the anesthetic procedure; Patients requiring tracheal intubation or supraglottic device during cesarean section; Patients who need to perform other surgical procedures concomitantly; Alcohol or drug addicts; Use of analgesics, opioids or not, within 24 hours prior to the procedure; Patients who report chronic pain in a previous cesarean operative wound; Inability to provide informed consent and low easily identifiable cognition; Patients with contraindication to neuroaxis blockade.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-82f4tb	Motor Imagery and Rehabilitation in Temporomandibular disorders	Not yet recruiting	Intervention	2019-06-21	<NULL>	<NULL>	2780	Graded Motor Imagery as an aditional tool for rehabilitation in Temporomandibular disorders	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2019-06-10	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-82f4tb	<NULL>	Individuals diagnosed with TMD, according to the RDC / TMD classification; who present pain as one of the main symptoms of the dysfunction; for at least 3 months and with intensity of at least 3 according to the Visual Analogue Scale (VAS).	History of previous central pathologies and / or cognitive alterations that make it impossible the comprehension of the methods that will be used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-8xbqk5	The Effect of Diet on the Renal Function of Renal Transplant Patients: Nutritional Status and Quality of Life	Not yet recruiting	Intervention	2019-06-21	<NULL>	<NULL>	2782	Effect of Nutritional Therapy on Renal Function of Individuals Undergoing Renal Transplantation: Evaluation of Nutritional Status and Quality of Life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8xbqk5	<NULL>	Individual volunteers, submitted to Kidney Transplantation at University Hospital Onofre Lopes (HUOL), of both genders, aged 18 years or over.	Individuals with a baseline diagnosis of Segmental and Focal Glomerulonephritis (GESF); performing multiple organ transplantation; history of recurrent transplantation due to chronic rejection; illiterate individuals who do not have a literate companion; individuals who did not complete all the steps foreseen in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-775d8m	Effects of using a Cell Phone Application while quitting smoking and satisfying participants of an existing Program	Not yet recruiting	Intervention	2019-06-26	<NULL>	<NULL>	2787	Effect of the use of a mobile application on smoking cessation and satisfaction of participants in a Specialized Program	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2019-06-18	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-775d8m	<NULL>	Smoking patients; in the age group between 25 and 70 years.	Patients with severe psychic comorbidities;illiterate; who are not available to attend face-to-face meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:58
RBR-3v3dqf	Effects of High Intensity Interval Training (HIIT) on Metabolic, Inflammatory, Arterial Stiffness and Myocardial Deformation in Obese women: a Randomized Clinical Trial	Not yet recruiting	Intervention	2019-07-05	<NULL>	<NULL>	2805	Effects of High-Intensity Interval Training (HIIT) on Metabolic, Inflammatory Parameters, Arterial Stiffness and Myocardial Deformation (STRAIN) in Obese women:a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-16	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-3v3dqf	<NULL>	Be female; be between 18 and 35 years of age; present a picture of obesity (BMI: greater than or equal to 30 kg/m²); individuals with body weight stabilized for at least 12 weeks; who have not participated in weight reduction programs before; not suffering from cardiopathies, diabetes and / or hypertension and endocrine diseases; non smokers; who are not making use of medicines that can alter cardiorespiratory and neuromuscular systems; with readiness to participate in evaluations and interventions; and signing of the Informed Consent Form (TCLE).	Volunteers who present in the clinical evaluation and / or laboratory tests any pathology or other complications that may be risk factors or adhesion to the regular practice of the proposed physical activity; and any other condition that could interfere with the test and /or intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-46hk7r	Effects of the Use of Rehabilitation Respiratory Instruments in Elderly with Voice Problems	Not yet recruiting	Intervention	2019-07-08	<NULL>	<NULL>	2806	Effects of the Use of Respiratory Instruments in the Rehabilitation of the Elderly with Dysphonia: A Randomized Clinical Trial	<NULL>	0, randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-46hk7r	<NULL>	patients aged over 60 years; of both sexes; with otorhinolaryngological diagnosis of dysphonia; who agree to participate in the study through the signing of the informed consent form	Patients with neurological and / or psychological disorders; patients miss more than one therapy session; will be excluded; and / or patients who have undergone previous or simultaneous speech-language therapy will not participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:59
RBR-9z5t9q	The efficacy of electrical stimulation to control the symptoms of nausea and vomiting in pregnant women.	Not yet recruiting	Intervention	2019-07-09	<NULL>	<NULL>	2810	TENS efficacy on the control of nausea, vomiting and hyperemesis gravidarum in pregnant women: a randomized, blind, placebo-controlled clinical trial.	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-9z5t9q	<NULL>	Pregnant women with symptoms of nausea (defined as an uncomfortable sensation associated with a desire to vomit), vomiting (defined as oral expulsion of gastric contents), and hyperemesis (characterized by persistent nausea and vomiting leading to dehydration, ketosis, (with a weight loss greater than 5% of the total weight), triggered during gestation, which compromise women&apos;s quality of life (classified with a minimum of 3 points evaluated by numerical scale of 0 to 10 points); aged 18 years or over and medical follow-up during prenatal care.	Alteration of pain and tactile sensitivity (assessed by Buck hammer needle test and esthesiometer) or presence of skin lesion in the upper limbs; Presence of a cardiac pacemaker; Gestation of risk; Carriers of neurological abnormalities; cardiopathies; cognitive disorders and physical limitations that make it impossible to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-539d97	&quot;Modifications in patients with subacute or chronic mechanical neck pain after osteopathic treatment and conventional physiotherapeutic treatment&quot;	Not yet recruiting	Intervention	2019-07-10	<NULL>	<NULL>	2813	&quot;Modifications in patients with subacute or chronic mechanical neck pain after osteopathic treatment and conventional physiotherapeutic treatment&quot;	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Fisioclinic	Fisioclinic	https://ensaiosclinicos.gov.br/rg/RBR-539d97	<NULL>	Patients with symptoms of cervical pain, diagnosed with subacute or chronic mechanical neck pain;Chronic mechanical neck pain (CMC);Patients with limitation in the opening of the mouth of less than 40mm, without the need to suffer symptoms in the ATM; Whole age (between 18 and 50 years old);With signed written consent;No difference of sex;Patients dysfunction or disorders in the high cervical	Any surgical intervention in upper limbs, head or spine at any time of their lives;Having received previous osteopathic treatment in the last two months;Having received medical treatment two weeks before the study;Refusal of the patient to participate in the study;Any Contraindication to the application of the treatment or evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-5j5shc	The Effects of the Hook on Cervical pain	Not yet recruiting	Intervention	2019-07-11	<NULL>	<NULL>	2817	The effects of Diacutaneous Fibrolysis in the evaluation of pain, functional status and muscular activity in patients with Cervical pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	UFJF - Universidade Federal de Juiz de Fora - MG	UFJF - Universidade Federal de Juiz de Fora - MG	https://ensaiosclinicos.gov.br/rg/RBR-5j5shc	<NULL>	"Individuals female. Age between 18 and 45 years.
Complaint of cervical pain. They must sign the TCLE: Free and Informed Consent Term."	Prior surgery in the scapular girdle region. Have received infiltration in the scapular girdle region in the previous three months. Present acute active local inflammatory processes. Present contraindications to diacutaneous fibrolysis: have wounds or skin disorders in the region of the shoulder girdle, have vascular changes, be under current treatment with anticoagulant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-5g9wfg	Impact of pharmaceutical care on patients with type 1 diabetes mellitus seen through the judical actions.	Not yet recruiting	Intervention	2019-07-19	<NULL>	<NULL>	2829	Clinical and economic impact of pharmaceutical care in patients with type 1 diabetes mellitus seen through the judicial actions: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Universidade Federal de São João Del Rei	Universidade Federal de São João Del Rei	https://ensaiosclinicos.gov.br/rg/RBR-5g9wfg	<NULL>	Patientes with type 1 diabetes mellitus, who obtain their insulines through judical actions.	Bedridden patients who can not attend the place of pharmaceutical consultations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:00
RBR-36y2xg	Evaluation of the efficacy of the formulation of topical anesthesia of Lidocaine / Articaine 4% and Lidocaine / Prilocaine 2.5% with and without Sodium Bicarbonate in the mucosa located posterior to upper canine teeth	Not yet recruiting	Intervention	2019-07-23	<NULL>	<NULL>	2834	Evaluation of the efficacy of the topical formulation of Lidocaine / Articaine 4% and Lidocaine / Prilocaine 2.5% with and without Sodium Bicarbonate in palatal mucosa of upper canines	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Sergipe	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-36y2xg	<NULL>	Criteria for inclusion of volunteers in the research: age between 18-35 years; ability to provide written consent; Undergraduate or graduate student of the dentistry department of the Federal University of Sergipe who has already undergone local anesthesia without intercurrences; Not having undergone anesthesia in the region in the two weeks prior to the study; Do not use medication that changes perception of pain in the 2 weeks prior to the study; Do not present systemic changes or a history of hypersensitivity to the drugs under study.	Individuals will be informed that it is permissible to leave the study at any time without any loss. The individual may be withdrawn from the study when he or she experiences an allergic reaction or clearly drug-related allergic reaction; To present non-drug-related systemic disease during the study, requiring concomitant therapy; Failure to comply with protocol requirements, including rules related to drug use, alcohol or lack of cooperation during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:01
RBR-3zyq7b	Intestine manipulation and functionality in patients with intestinal constipation	Not yet recruiting	Intervention	2019-07-31	<NULL>	<NULL>	2855	Intestine manipulation and functionality in patients with intestinal constipation: randomized controlled double blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Colegio Brasileiro de Osteopatia	Colegio Brasileiro de Osteopatia	https://ensaiosclinicos.gov.br/rg/RBR-3zyq7b	<NULL>	Inclusion criteria will be adults; of both genders; aged between 18 and 60 year;s and who present a complaint of Chronic Intestinal Constipation (more than 6 months), that fit the definition of Functional Constipation in the Rome Consensus III;	Adults with an incision or tumor in the abdominal region; fractures; rheumatic diseases; acute infectious disease; or impossibility of understanding the proposed evaluations will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-9xnf8r	Chemistry evaluation and patients satisfaction in relation to carbamide peroxide bleaching gels: clinical trial	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2862	Evaluation of degradation, pH and patient satisfaction with 20-22% carbamide peroxide gel flavour in at-home bleaching: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-13	Instituto de Ciência e Tecnologia de São José dos Campos	Instituto de Ciência e Tecnologia de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-9xnf8r	<NULL>	minimum of 18 years old; good general health; patients who want to retouching of bleached teeth (bleaching treatment previously); abscence of gingival recession, non carious cervical lesion, active carie or periodontal disease; do not use fixed orthodontic appliances or removable prosthesis; pressent all teeth upper and lower sencond premolars; and avaiability for recurring returns	Chemical dependents, smokers ou alcoholics; medical conditions in which can interfere in volunteer security (medicines for the treatment of chronic diseases or allergic reactions to substances to be used); pregnancy; be in another study in the same period; present bruxism, periapical alterations ou tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:02
RBR-7yqk5p	Effect of manual therapy in subjects with cardiovascular disease	Not yet recruiting	Intervention	2019-08-09	<NULL>	<NULL>	2867	Autonomic responses of coronary patients submitted to a protocol of osteopathic techniques: a crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-15	Núcleo de Pesquisa do Instituto Docusse de Osteopatia e Terapia Manual	Núcleo de Pesquisa do Instituto Docusse de Osteopatia e Terapia Manual	https://ensaiosclinicos.gov.br/rg/RBR-7yqk5p	<NULL>	Men with a diagnosis of ischemic coronary disease; above 45 years of age; who do not present a history of smoking or alcoholism; cardiovascular rehabilitation program followers who do not present a historical recruitment period for infections; do not present with unstable angina; controlled hypertension; without significant valvular disease; without uncontrolled metabolic disease	Volunteers will be excluded from the study when time series records of RR intervals show less than 95% of sinus beats; absence of attendance in at least one of the stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:03
RBR-44rc4n	Effect of the use of Dexamethasone 4mg in the control of pain after the end of the treatment of the canal	Not yet recruiting	Intervention	2019-08-20	<NULL>	<NULL>	2885	Post-operative pain control with the use of Dexamethasone4mg in patients submitted to endodontic treatment with foraminal enlargement	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-10	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-44rc4n	<NULL>	Patients in need of endodontic treatment. Both genders. ASA I and ASA II patients. Patients over 18 years of age.	Patients with a history of allergy to local anesthetics, corticosteroids and starch. Patients who used analgesics or anti-inflammatories 12 hours before the procedure. Patients were given antibiotics 48 hours before the procedure. Pregnant or lactating patients. Uncontrolled diabetic patients. Patients with open apex. Patients who needed antibiotic prophylaxis prior to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-387ntq	Effects of Perineal Stretching in pregnant women who performed Exercises in the Perineal Region	Not yet recruiting	Intervention	2019-08-22	<NULL>	<NULL>	2889	Effects of Perineal Stretching in pregnant women performing Pelvic Floor Muscle Training: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-387ntq	<NULL>	Inclusion criteria will be considered: age over 18 years; gestational age of 33 weeks; primigravidae; physiological gestation; medical authorization to perform the intervention; pregnant women wishing to deliver vaginally; present medical certificate of release for participation in the research. For the pregnant women who will be part of the T Group, they will also have as inclusion criterion to have performed PFMT, during the gestational period, offered by the project approved by CEP / UFU, 3,054,152. For the pregnant women of the NT Group, the criterion is not to have performed PFMT.	The exclusion criteria will be: multiple gestation; presence of bone deformities; important muscular and nervous dysfunctions; presence of high gestational risk; unusual fetal position or risks that make vaginal delivery impossible (placenta previa); presence of risk of ascending infection; presence of vaginal bleeding; presence of cervical cancer; inability to contract the pelvic floor muscles; intolerance to vaginal palpation; presence of neurological and / or cognitive deficits that prevent the understanding of the procedures; use of prenatal pelvic floor preparation methods before being part of the study; being visibly under the influence of drugs or alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-3s36zh	Rabies prevention: assessing the effect and cost of three (03) vaccination strategies	Not yet recruiting	Intervention	2019-08-23	<NULL>	<NULL>	2893	Rabies pre-exposure prophylaxis: Cost-effectiveness analysis of three (03) vaccination strategies	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-26	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-3s36zh	<NULL>	Travelers; veterinarians; other professionals with occupational risk of exposure to rabies virus over the age of 18 years	Pre-or post-exposure rabies vaccine use; Severe allergy reported to any component of the vaccine; reported pregnancy; Disability to attend study visits; Abuse of illicit substances; Moderate to severe psychiatric illness; Immunosuppressive disease; Use of immunosuppressant medication for any reason within six (06) months prior to the study inclusion visit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:04
RBR-56xh4c	Efficacy and safety evaluation of new model of  intraocular lenses for cataract surgery.	Not yet recruiting	Intervention	2019-08-27	<NULL>	<NULL>	2897	Efficiency and efficacy study of a new family of monofocal and multifocal intraocular lenses in the Cataract Personalized Solution Project.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital Evangélico de Belo Horizonte	Hospital Evangélico de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-56xh4c	<NULL>	"Patients who had a clinically documented diagnosis of age-related cataract (cortical, nuclear, sub-capsular or a combination) that was considered amenable to cataract extraction by the intracapsular facectomy method.
Adult patients 21 years of age or older.
Patients eligible for primary intraocular lens implantation.
Patients willing and able to perform clinical and follow-up examinations for a minimum of 1 year after cataract surgery.
Patients requiring intraocular lens implantation powers ranging from 10 to 30 diopters.
Patients with a visual potential of 20/40 or better in the eye indicated for intraocular lens implantation.
Patients with a corneal cylinder corrected for less than 1 diopter."	"Patients with any pathology of the anterior segment in which the intracapsular facectomy procedure with primary IOL implant is contraindicated (examples: keratoconus, dystrophy or corneal scars, anterior uveitis).
Patients with corneal inflammation or edema, including but not limited to: keratitis, keratoconjunctivitis and ceratouveitis.
Patients with uncontrolled glaucoma or glaucoma under treatment.
Patients with history of retinal detachment.
Patients with diabetic retinopathy (proliferative or non-proliferative).
Patients with congenital, metabolic, traumatic or complicated cataract.
Patients with marked microphthalmia or aniridia.
Patients who had previous ocular surgery of the proposed eye.
Patients who have already received other IOLs in the contralateral eye.
Irregular corneal astigmatism.
Amblyopia.
Clinically significant changes in the retinal / macular pigment epithelium.
Neovascularization of the iris, the camerular and retinal angle.
Severe recurrent inflammation of the anterior or posterior segment of unknown etiology.
Optical atrophy.
Patients with immunodeficiency (infectious, neoplastic or drug).
Patients on chronic systemic steroid use or immunosuppressive drugs.
Patients simultaneously participating in another clinical trial.
Patients with a strong dependence on intermediate vision, night vision, or specific occupational requirements (eg, commercial pilots and professional drivers)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-3w3kmg	Study on the application of mobilization in the first 48 hours of hospitalization in comparison to the mobilization associated with muscle stimulation with electrical impulses in patients hospitalized in the ICU	Not yet recruiting	Intervention	2019-04-08	<NULL>	<NULL>	2905	Randomized trial about the application of an early mobilization protocol in comparison with early mobilization associated with neuromuscular electrical stimulation in critically ill patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-07	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3w3kmg	<NULL>	Patients admitted to the ICU for less than 48 hours; older than 18 years; both sexes; signature of the Free and Informed Consent Form is mandatory; exclusion criteria	Inability to walk without assistance before the acute illness that led to ICU admission; Previous neuromuscular disease that may delay or stop the ventilatory weaning (such as severe myasthenia, amyotrophic lateral sclerosis); Hip fracture, unstable cervical or pathological fracture (patient with block mobilization)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:05
RBR-8nkhhk	Safety and efficacy of intramuscular vaccination without aspiration before injection: a randomized clinical trial	Not yet recruiting	Intervention	2019-09-03	<NULL>	<NULL>	2923	Safety and immunogenicity in intramuscular injection of vaccine without aspiration prior to injection: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-23	Universidade Federal de Alagoas - UFAL	Hospital Universitário Professor Alberto Antunes - HUPAA	https://ensaiosclinicos.gov.br/rg/RBR-8nkhhk	<NULL>	Healthy volunteers; both genders; age between 18 and 59 years.	Individuals with immunosuppressive disease or treatment; acute febrile illness; made use anti-inflammatory drug, analgesic or antipyretic 24 hours before vaccination; history of allergic reaction to any of the components of the Hepatitis A vaccine; pregnant women; history of hepatitis A disease; history of vaccination against Hepatitis A; previous titration of antibodies against the Hepatitis A virus (anti-HAV IgG); persons undergoing blood transfusion or use of blood products in the last 28 days; persons who are unable to respond on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-7zwzs3	Analysis of Cinnamaldehyde to be used in the Treatment of Fungal Infection due to the use of dental prostheses	Not yet recruiting	Observational	2019-09-03	<NULL>	<NULL>	2924	Efficacy and Safety of Cinnamaldehyde in the Treatment of Buccal Candidiasis associated with the use of dental prostheses: Clinical Trial, Randomized, Controlled and Blind	<NULL>	1-2, randomized-controlled, triple-blind	1-2	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7zwzs3	<NULL>	"Fase I: The study will include healthy individuals and users of upper removable total prosthesis, belonging to the age group from 40 to 70 years.
In order for there to be no confusion of signs and symptoms relevant to possible adverse effects of the test product with signs and symptoms of disease, healthy subjects were selected as defined by the Phase I clinical trial definition.
fase II: Individuals belonging to the age group from 40 to 70 years old, with oral candidiasis and dental prosthesis user, with a signed and signed Free and Informed Consent Term."	Fases I e II: Individuals undergoing topical and / or systemic antimicrobial treatment and who have a sensitivity reaction to cinnamaldehyde, cinnamon or Miconazole.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:06
RBR-45nf55	Evaluation of the association of removable partial denture supported by implants distal extension.	Not yet recruiting	Intervention	2012-04-23	<NULL>	<NULL>	2938	Evaluation of the remaining alveolar ridge height, the masticatory efficiency and success rate of implants in patients with Kennedy Class I arches rehabilitated with removable partial dentures supported by implants.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-15	Neodent	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-45nf55	<NULL>	"All patients should have been rehabilitated at the Federal University of Rio Grande do Norte;
Every patient should be bilateral mandibular posterior edentulous;
Every patient should be larger than toothless in order to standardize the sample;
The patient must have a height between the mandibular canal and the alveolar bone margin posterior of at least 7mm."	"Will be excluded from the sample patients over 70 years or a weakened state of health;
Diabetic patients;
Patients with osteoporosis;
Patients with periodontal disease, patients not signing the consent form."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-8s6cwz	Investigation of the effectiveness of elastic taping associated with thigh and hip strengthening in the treatment of anterior knee pain	Not yet recruiting	Intervention	2019-09-13	<NULL>	<NULL>	2942	Investigation of the efficacy of Kinesio Taping method with an exercise protocol to the treatment of Patellofemoral Pain: A randomised, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-15	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-8s6cwz	<NULL>	"Inclusion criteria: 

Women;
Aged between 18 and 40 years;
Clinical diagnosis of patellofemoral pain (PFP);
Unilateral or bilateral symptoms;
History of anterior knee pain for at least three months;
Worsening pain in at least two PFP-related activities, such as climbing and descending stairs, jumping, kneeling, sitting for a long period;
Pain on palpation of the medial or lateral facet of the patella."	"Exclusion criteria:

Women with any degree of osteoarthritis;
History of previous surgery on the spine, hips, knees, ankle or foot;
History of patellar instability or patellar dislocation (traumatic or atraumatic);
History of a previous ligament or meniscal injury;
Sensibility to the material used to apply the Kinesio Taping method."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:07
RBR-3h5sc8	Adding expiratory muscle training to breath stacking technique on clinical and functional outcomes in patients with neuromuscular disease	Not yet recruiting	Intervention	2019-09-17	<NULL>	<NULL>	2955	Comparison between maximal insufflation technique associated with expiratory muscle training with maximmum isolated insufflation in patients with neuromuscular diseases	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Escola Superior de Ciências da Saúde	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3h5sc8	<NULL>	"Diagnosis of neuromuscular disease confirmed by neurologists at the referral center for neuromuscular diseases at Brasília Support Hospital prior to screening for recruitment; age over 16 years; preserved cognition, evidenced by a score greater than or equal to 24 points in the Mini-Mental Status Exam;no barium allergies; without tracheostomy or mechanical ventilation; no diaphragmatic pacemaker
- without associated respiratory disease"	less than 16 years; pregnancy; previous kidney disease or other concomitant diseases; respiratory diseases during the study; hospitalization in intensive care units (ICUs) during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:08
RBR-9b3fzp	High intensity interval exercise and cardiopulmonary capacity	Not yet recruiting	Intervention	2019-09-20	<NULL>	<NULL>	2976	Effect of different protocols of high intensity interval exercise with low volume on the cardiorespiratory capacity of inactive adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9b3fzp	<NULL>	The inclusion criteria in the study are: age between 18 and 40 years;  male and female sex;  be apparently healthy;  physically inactive (ie individuals who perform less than 150 min / week of moderate physical activity or less than 75 min / week of vigorously active physical activity regularly for at least three months (verified by accelerometer) ; Body mass index (BMI) between 18.5 kg / m2 and 29.9 kg / m2;  without ostiomioarticular lesions; have experience with treadmill exercise.	The exclusion criteria of the study are:  individuals who regularly practice high intensity interval exercise;  use of drugs that modulate cardiorespiratory function;  being smoker or stopped recently (in the last 6 months) and  any type of injury that makes it impossible to continue the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-9frj8q	Effects evaluation of web-based tailored tool to prevent mistreatment among intimate partners	Not yet recruiting	Intervention	2019-09-20	<NULL>	<NULL>	2980	Usability and efficacy evaluation of a web-based tailored intervention to prevent dating violence	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Departamento de Psicologia Clínica da Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9frj8q	<NULL>	It will be included youth aged 15 - 29 years old involved in a current affective-sexual relationship	"To have less than 15 years old and more than 29 years old;
Do not be involved in a current affective-sexual relationship during recruitment phase"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:09
RBR-99gyq8	Effects of pulmonary rehabilitation-associated melatonin hormone on sensation of difficulty breathing, respiratory muscle strength, ability to perform daily living activities and sleep quality in individuals with chronic lung disease	Not yet recruiting	Intervention	2019-09-24	<NULL>	<NULL>	2989	Effects of pulmonary rehabilitation-associated melatonin on dyspnea, respiratory muscle strength, functional capacity, and sleep quality in individuals with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-03	Universidade Federal do Ceará Programa de Pós Graduação em Ciencias Médicas	Centro Universitário Estácio do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-99gyq8	<NULL>	Selection criteria for rehabilitation program will includ patients from the Pulmonology Service of the WCUH-FUC; of both sexes; above 18 years; with medical diagnosis of Chronic obstructive pulmonary disease based on the Global obsctructive lung disease guideline; stability with no exacerbations or worsening of respiratory symptoms; no increased use of rescue medication and ability to mobilize independently	The exclusion criteria for rehabilitation program will be the patient will submit to exacerbation of Chronic obstructive pulmonary disease; orthopedic or neurologic impairment that might render the subjects incapable of completing the exercise training; patients who not continue rehabilitation for 12 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-66359j	Evaluation of inhaled medications to improve breathing during exercise in patients with Pulmonary Arterial Hypertension	Not yet recruiting	Intervention	2019-09-25	<NULL>	<NULL>	2996	Evaluation of inhalation inteventions to attenuate the abnormalities of respiratory mechanics during patient&apos;s exercise whit pulmonary arterial hypertension	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Rio Grande do Sul	Fundo de Incentivo à Pesquisa e Eventos (FIPE)	https://ensaiosclinicos.gov.br/rg/RBR-66359j	<NULL>	Patients diagnosed with pulmonary arterial hypertension according to the Nice classification, 2013, confirmed by right cardiac catheterization at rest. Stable drug treatment in the last 3 months. Symptomatic, with dyspnoea. In functional class of the New York Heart Association II and III.	Non-HAP Pulmonary Hypertension, that is, Groups 2 to 5 will be excluded, as well as patients with other comorbidities that may cause limitation of exercise capacity. Use of prolonged home oxygen therapy. That they present FEV1VF &lt;0.7. Be involved in regular physical activity programs in the last 3 to 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:10
RBR-3wrnrf	Effect of fibers on intestinal transit and inflammation of patients with Pre-Dialytic Chronic Renal Disease	Not yet recruiting	Intervention	2019-09-28	<NULL>	<NULL>	3010	Effect of prebiotics on intestinal transit and inflammation profile of patients with Pre-Dialytic Chronic Renal Disease.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-30	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-3wrnrf	<NULL>	Patients with non-dialytic stage V chronic kidney disease; over 18 years of age; who do not have gastroenterological pathologies; do not have cancer; and do not use continuous laxatives	Patients younger than 18 years of age; with gastroenterological pathologies; pregnant women of any gestational age; cancer; patients on continuous use of laxatives; patients with CKD of any other stage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-263wr8	Immediate effects of different Physical Therapy Techniques in the Balance of non-exercising elderly women	Not yet recruiting	Intervention	2019-10-01	<NULL>	<NULL>	3016	Acute Effects of different stabilization techniques of Proprioceptive Neuromuscular Facilitation on the Balance of Sedentary Elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-10	UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - ESCOLA DE EDUCAÇÃO FÍSICA FISIOTERAPIA E DANÇA	UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - ESCOLA DE EDUCAÇÃO FÍSICA FISIOTERAPIA E DANÇA	https://ensaiosclinicos.gov.br/rg/RBR-263wr8	<NULL>	Women who are 70 years of age or older will be included in the study. That they do not perform regular physical exercises and that they do not present chronic labyrinthitis; diseases of the central nervous system such as multiple sclerosis and cerebral palsy; abnormalities of the spinal cord such as trauma or degeneration of the spinal cord; peripheral nerve diseases such as peripheral neuropathy; degenerative muscular diseases like muscular dystrophy; myotonic dystrophy and myositis; skeletal abnormalities and diseases such as skeletal dysplasia and chondrodystrophy; blindness; Parkinson&apos;s disease; stroke with sequelae of spasticity or hypotonia.	Older people who are not able to perform the tests proposed during the evaluations will be excluded from the counting and statistical procedure of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-54xy8b	Efficacy of tylex-associated to a desensitizer in tooth sensitivity induced by office bleaching	Not yet recruiting	Intervention	2019-10-01	<NULL>	<NULL>	3019	Efficacy of codeine/paracetamol-associated to a desensitizer in tooth sensitivity induced by office bleaching: a randomized, controlled, triple-blind clinical trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-54xy8b	<NULL>	Patients should be at least 18 years of age; good general and oral health; upper anterior teeth with no restorations; never bleached before.	Patients who present previous restorations; pregnant or breastfeeding; have discoloration of the dental element caused by trauma; severe fluorosis; darkening caused by endodontic treatment and requiring internal bleaching (non-vital); habits of bruxism or without good oral health; any previous or current health problems (in the stomach, heart, kidney and liver); continuous use of anti-inflammatory drugs and/or analgesics; systemic diseases such as diabetes, hypertension; known allergy to codeine phosphate 30mg/paracetamol 500mg.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-7bn9gc	Reduction of preoperative fasting time on scheduled cesarean section	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3022	Abreviation of the fasting pre-operative in the cesarean elective	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-05	Hospital Universitário Julio Müller HUJM	Universidade Federal de Mato Grosso UFMT	https://ensaiosclinicos.gov.br/rg/RBR-7bn9gc	<NULL>	Women 18 to 40 years of age; above 39 gestational weeks Present body mass index (BMI kg / m²) suitable for gestational age according to the chart of Atalah et al 1997 Single fetus Elective caesarean with wall opening abdominal pain by the Pfannenstiel technique Present ASA (American Society of Anesthesiologist) score I and II Be submitted to the regional anesthetic technique; Ability to understand the rationale of the study evaluations; Signed the free and informed consent form.	Patients who do not adhere to the protocol at any stage of the study and who present: Anemia (Hb &lt;11.0 g / dL); Gestational Diabetes (Fasting glycemia above 95 mg / dL by the TGO reference value: (&gt; 140/90 mmHg); Renal or hepatic disease; C-reactive protein&gt; 6.0 mg / L; Clinical repercussion of gastroesophageal reflux for the gravidic condition (Hyperemesis gravidarum, abnormal anatomy of the upper gastrointestinal tract); Operating time greater than two hours; Blood collection in the non-scheduled period; Preoperative complications requiring an emergency or major intraoperative cesarean section (eg hemorrhage).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:11
RBR-2kkb6d	Analysis of the effectiveness of cinnamon in the reduction of sugar and fat levels of adults with type 2 Diabetes	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3023	Analysis of the effectiveness of cinnamon (Cinnamomum verum) in the reduction of glycemic and lipidic levels of adults with type 2 Diabetes	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2kkb6d	<NULL>	Volunteers of both genders; aged between 18 and 80 years; diagnosis of type 2 diabetes confirmed for at least five years; taking oral antidiabetics; with HbA1c values between 6.5 and 8.0%; preserved cognitive functions.	Volunteers with cinnamon allergy; Patients who use another herbal medicine for diabetes treatment; Patients using cinnamon for diabetes treatment; Patients diagnosed with alcoholic liver disease, cirrhosis or abnormal basal liver function; Patients on insulin therapy; Women breastfeeding, pregnant or on contraceptives; Patients with heart, liver or respiratory failure; Patients with bleeding disorders and who are taking coumarin derivatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-8w44f6	Clinical trial of the effect of breathing exercise on expiratory force and abdominal muscle in stroke patients	Not yet recruiting	Intervention	2019-10-02	<NULL>	<NULL>	3024	Effect of Respiratory Muscle Training on expiratory muscle strength and abdominal electrical activity in the acute phase of Stroke: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-05	Hospital das Clínicas da Faculdade de Medicina de Botucatu - UNESP	lorena	https://ensaiosclinicos.gov.br/rg/RBR-8w44f6	<NULL>	Patients aged 18 years and under 80 years of age admitted to the stroke unit of the Clinical Hospital of the Botucatu Medical School, with clinical diagnosis of ischemic stroke by magnetic resonance or computed tomography with up to 80 years will be evaluated. 72 hours of the ictus, absence of disability prior to hospitalization with score less than or equal to 1 in eMR, item 1a (level of consciousness), 1c (Commands: open / close eyes, shake and release hand), language and facial paresis NIHSS less than equal to 1, no previous dementia or other associated neuromuscular diseases, no severe valvulopathy and previous major thoracic or abdominal surgery under 1 year, no congestive heart failure class III and IV, no asthma or decompensated chronic obstructive pulmonary disease (COPD) with a closed diagnosis.	Patients with previous complaints of dysphagia, clinical instability, invasive mechanical ventilation or palliative care will be excluded, those who fail to perform the MIP / MEP assessment protocol, ventilometry, non-adaptation to training, worsening of clinical and hemodynamic status and those who do not agree to participate in the study or refuse to continue the training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-6yg2z9	Immunoprophylaxis with BCG vaccine combined with the use of rifampicin in a single dose in contacts less than 15 years old at home of patients with Leprosy	Not yet recruiting	Intervention	2019-10-03	<NULL>	<NULL>	3032	Immunochemioprophylaxis in the prevention of Leprosy contacts in children under 15 years of age	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de Mato Grosso	Universidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-6yg2z9	<NULL>	Individuals younger than 15 years (5 years to 14 years, 11 months and 29 days); household contacts of new leprosy cases diagnosed and registered in the National Notification of Injury Information System (SINAN/MT) in 2018 (treatment or treatment virgin) up to 4 weeks of MDT use) of both sexes; who resided or resided within five years before/during the diagnosis of the index case.	It is those who refuse to undergo the clinical examination; who are diagnosed with leprosy during the examination; those who have a history of hypersensitivity after the previous dose of the vaccine or any component of the vaccine; pregnant women, patients receiving high dose corticosteroids ( 2 mg/kg/day for children up to 10 kg or 20 mg/kg/day for individuals over 10 kg) for a period of more than two weeks; patients taking other immunosuppressive therapies (antineoplastic chemotherapy, radiotherapy, among others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:12
RBR-8cb56q	Comparison between debriefing techniques for support diagnostic reasoning in nursing students	Not yet recruiting	Intervention	2019-10-07	<NULL>	<NULL>	3038	Debriefing techniques as a help tool for diagnostic  reasoning of nursing students  randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-05	Marcella Ferroni Gouvea	Marcella Ferroni Gouvea	https://ensaiosclinicos.gov.br/rg/RBR-8cb56q	<NULL>	Students registered in the second year of undergraduate Nursing course at the Federal University of Viçosa; and which are studying the discipline &quot;Nursing Skills II; both sexes; age  18 years old	It will be excluded from this study, students with training in other higher or technical courses in health; those who already have skill as a professional in the preparation of nursing diagnoses; who do not accept to participate in this research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-587ptd	Health Product Irritability and Sensitization Assessment through Contact Test	Not yet recruiting	Observational	2019-10-08	<NULL>	<NULL>	3052	Assessment of Primary, Accumulated Dermal Irritability and Health Product Sensitivity by Patch Test _Mklab	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-18	Ipclin - Pesquisa Clínica Integrada	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-587ptd	<NULL>	"Healthy skin in the region of study (back); Age 18 to 65 years; Gender: male or female; Participants with phototypes I, II, III and IV (according to the Fitzpatrick classification); No history of irritation / allergy to the material used in the study; o Have signed the Informed Consent Form (FICF);
Participants wishing to participate in the study without financial gain. They will be reimbursed for test-related expenses such as transportation and food."	"Participants who refuse to participate in the study in question.
Skin tags in the experimental area that interfere with the evaluation of possible skin reactions;
Active dermatoses (local and widespread) that may interfere with the study results;
Pregnant or lactating women;
History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines;
o Volunteers with a history of allergy to the material used in the study;
History of atopy;
History of conditions aggravated or triggered by ultraviolet radiation;
carriers of immunodeficiencies;
Kidney, heart or liver transplantation;
Intense sun exposure or tanning session up to 15 days prior to initial assessment;
Prediction of intense sun exposure or tanning session during the study period;
Prediction of bathing in the sea, pool or sauna during the study;
Participants who practice water sports;
Use of the following systemic topical drugs: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection;
Treatment with acidic vitamin A and / or its derivatives orally or topically within 1 month before the start of the study;
Expected vaccination during the study or up to 03 weeks before the study;
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-4b7tyd	Physical activity intervention with motion sensors in adolescents	Not yet recruiting	Intervention	2019-10-09	<NULL>	<NULL>	3054	Effect of a physical activity intervention - home based on cardiometabolic risk factors  in  adolescents	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-10	Gessika Castilho dos Santos	Antonio Stabelini Neto	https://ensaiosclinicos.gov.br/rg/RBR-4b7tyd	<NULL>	Be enrolled in basic education regularly; be between 13 and 18 years old; being overweight or obesity ( greater than 85th percentile); not be diagnosed with: cardiovascular disease, diabetes,  hypertension; not having been participating in a physical activity or exercise program for at least three months; do not have any kind of genetic, neoplastic or mental disease.	The adolescente will be excluded if: he/she doesn´t meet the pre-participation recommendations in the physical tests and did not participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:13
RBR-6pxpvx	Health of school children with food difficulties who receive supplementation for six months	Not yet recruiting	Intervention	2019-10-09	<NULL>	<NULL>	3058	Clinical evolution of pre-school children with feeding difficulties supplemented during six months: a prospective controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de São Carlos	Clínica Nutre	https://ensaiosclinicos.gov.br/rg/RBR-6pxpvx	<NULL>	Age between 24 and 60 months. Presence of feeding difficulty characterized as at least one of the aspects mentioned below by parents or guardians to the professional who referred and validated in the initial assessment made by the nutritionist, namely: Inadequate amount of macro and / or micronutrient intake; Inadequate quality of food; Inadequate variety of food; Presence of one of the eating difficulty criteria elaborated by Kerzner et al and described in the IMFED system, namely: Misinterpretation of parents; Agitated child with little appetite; Emotionally compromised or neglected child; Presence of organic disease; Highly selective ingestion Food phobia.	Presence of cow&apos;s milk protein allergy; Presence of lactose intolerance; Impossibility of oral feeding; Presence of neoplasia, renal failure, liver failure; or heart disease under treatment; Presence of genetic syndrome; Presence of anorexia nervosa; Presence of chronic diarrhea or inflammatory bowel disease; Delayed growth and development related to chronic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-5xrnrm	Effect of orientation on stress and quality of life of elderly relatives with behavioral changes	Not yet recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3067	Effect of an educational intervention on the emotional or psychological distress and quality of life of family caregivers of elderly with neuropsychiatric symptoms	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-18	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5xrnrm	<NULL>	Inclusion criteria for the elderly to be 60 years of age or older; male or female; with medical diagnosis of Alzheimer&apos;s disease or mixed dementia; classified as mild dementia or moderate dementia; in the outpatient clinic of geriatrics and dementias; presenting one or more neuropsychiatric symptoms and being cared for by a family member. inclusion criteria for the caregiver be the main family caregiver of the elderly selected for the research; reside with the elderly; male or female; aged 18 years or over; reside in the city of Ribeirão Preto; present emotional or psychological erosion and present a preserved cognitive state	Exclusion criteria for the elderly be institutionalized; classified as severe dementia.there is no exclusion criterion for the caregiver	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-36dr7t	Effect of a toothpaste containing fluorine, calcium and phosphate for the treatment of tooth sensitivity.	Not yet recruiting	Intervention	2019-10-10	<NULL>	<NULL>	3069	Effect of a fluoride, calcium and phosphate dentifrice on the treatment of dentin hypersensitivity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Norte do Paraná - UNOPAR	Editora e Distribuidora Educacional S/A	https://ensaiosclinicos.gov.br/rg/RBR-36dr7t	<NULL>	Adult patients; age between 18 and 45 years; both genders; healthy; without systemic changes or continuous use of medications; having at least one tooth with an exposed root surface caused by abrasion, abrasion, erosion or gingival recession from which a painful response is elicited by a blast of air	PPatients with physiological changes; not classified as ASA I (pregnant women, patients with chronic diseases, patients with infectious foci in the oral cavity); teeth with evidence of pulpitis (tooth nerve pain), carious lesions, defective restorations, and active severe periodontal (gum) disease; use daily analgesic medication or any other medication that may mask painful symptoms; routinely use desensitizing toothpaste or any other desensitizing agent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:14
RBR-5rzmzf	Care plan for carers of people with dependency	Not yet recruiting	Intervention	2019-10-11	<NULL>	<NULL>	3078	Instrumentation of informal caregivers of care-dependent patients during hospital-to-home transition	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-5rzmzf	<NULL>	"Care dependent person: age between 18 and 59 years; be the first episode of hospitalization for disabling illness; in the emergency care sectors; medical clinic or post-surgery sector of the University Hospital and Municipal Hospital; minimal upward forecast; have a Barthel index of 10 to 30 evaluated at the time of research recruitment;
 
Informal caregiver: 18 years of age and over and less than 80 years old; be primary informal caregiver; reside in the municipality; be literate; able to read and write; no intention to move the municipality during the research period; and be classified in the Mini Mental State Examination with scores between 22 24 and 26 according to educational level"	"Care dependent person: be transferred to a hospital or care institution other than home; need specialized health care;

Informal Caregiver: do not speak Portuguese"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-5kbzdh	Dietary supplementation with Omega in pregnant and the placentary vascular resistance assessed through the doppler of the uterine arteries	Not yet recruiting	Intervention	2018-06-19	<NULL>	<NULL>	3086	Dietary supplementation of Omega 3 and the participation in the placentary vascular resistance mechanism in pregnant people: a comparison with normal pregnant women without use of Omega, chronic hypertensions in use of AAS and  pregnants with thrombophilia and use Heparina or  AAS	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Faculdade de Medicina de Barbacena	Faculdade de Medicina de Barbacena	https://ensaiosclinicos.gov.br/rg/RBR-5kbzdh	<NULL>	"Pregnant women enrolled in prenatal care of the institution.
Pregnant women who signed the free and informed consent form.
Pregnant women who attend the appointments (with even a missed prenatal) and agree to perform the protocol of the service, clinical examinations and imaging.
Pregnant women with hereditary or acquired thrombophilias identified
previously.
Pregnant women with identified risk factor for preeclampsia or CIUR selected from ACOG and NICE data adapted for this study:
i. Identification of two anamnesis clinical data (clinical history of PE in previous pregnancy, history
PE in first-degree relative, BMI&gt; 35 kg / m2, hypertension, nephropathy, disease
autoimmune).
ii. Identification of anamnesis clinical data associated with changes in uterine artery doppler in the
first trimester (IR, PI or bilateral doppler notch).
iii. MAP identification&gt; 100 in the first trimester of pregnancy associated with clinical history or Doppler
altered uterine artery (PI, IR, uterine artery notch)."	"Pregnant women - under 19 years.
Pregnant women who are absent from consultations - two or more consecutive prenatal absences.
Pregnant women who do not accept to use the omega in the prenatal or have intolerance to the use of the omega.
Smoking patients.
Gestantes without risk factor or thrombophilia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:15
RBR-2kt4fj	The use of health applications and its relationship with the eating practices of adults and elderly individuals from Passo Fundo (RS)	Not yet recruiting	Intervention	2019-10-15	<NULL>	<NULL>	3092	Influence of the use of health applications on eating practices of adults and elderly individuals from Passo Fundo (RS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Luísa Victória Biasi	Universidade de Passo Fundo (UPF)	https://ensaiosclinicos.gov.br/rg/RBR-2kt4fj	<NULL>	Have a smartphone with Android OS version 4.3 or higher; affinity with the use of applications; have internet at home and / or mobile	Pregnant women; elderly aged 80 years or older; people in need of special diets	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-2dc8kz	Effects of the selective strengthening technique for the internal musculature of the foot in type II diabetic volunteers. Randomized and controlled study	Not yet recruiting	Intervention	2019-10-17	<NULL>	<NULL>	3104	Effects of the selective strengthening technique for intrinsic skin musculature in diabetic volunteers of type II. Randomized and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2dc8kz	<NULL>	Type II diabetes mellitus, according to American Diabetes Association criteria; between 20 and 70 years old; of both sexes; in diet therapy or with oral antidiabetic drugs  and signing the term of free and informed consent.	Individuals with type II DM with very high risk, ie those with previous ulcers and / or amputations, clinical diagnosis of hemiplegia, paraplegia, or Parkinson&apos;s disease; limb amputation; a history of alcohol or drugs; a herniated disc; leprosy; severe arthritis that prevents walking; insanity; intellectual disability; and other psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:16
RBR-9fv3f4	Evaluation of the use of Pioglitazone combined with conventional Antifungals for treatment of meningitis caused by the fungus Cryptococcus	Not yet recruiting	Intervention	2019-10-17	<NULL>	<NULL>	3106	Randomized double-blind Pioglitazone repositioning trial combined with Antifungals for treatment of Cryptococcal Meningitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9fv3f4	<NULL>	Older than 18 years. Cryptococcal meningitis.	Under 18 years. Pregnancy. Diabettes mellitus. Active liver failure. Bladder tumor. Recurrence of cryptococcosis. Prior antifungal therapy. Hypoglycemia. Congestive heart failure. Hypersensitivity to pioglitazone. Sertraline. Amiodarone Atorvastatin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-2rnbw6	Relationship between oxytocin and borderline personality disorder	Not yet recruiting	Intervention	2019-10-20	<NULL>	<NULL>	3111	Association assessment between oxytocin and borderline personality disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2rnbw6	<NULL>	"women over 18 years of age; literate; of childbearing age; in contraceptive use for more than six months; who agree to participate by signing the Free and Informed Consent Form approved by the Ethics and Research Committee of the HCFMRP; who agree to measure levels of estrogen and progesterone to delineate the menstrual cycle; that are in the follicular phase of the cycle. For inclusion in the TPB group, women should have: a diagnosis of BPD performed using the criteria established by the DSM-5 classification; being in outpatient treatment.
In the control group, only women with no history of current or previous psychiatric disorder evaluated by SCID-5 will be admitted. In the study of continuous use, they will be admitted to women with BPD of childbearing age, over 18 years of age, without pretense of becoming pregnant within the next 6 months, who are literate and who agree to participate and sign the ICF approved by the HCFMRP Ethics and Research Committee. In addition, in this group, only women with a diagnosis of BPD will be accepted, based on the criteria established by the classification of DSM-5 (APA, 2014), in outpatient treatment; who agree not to modify their treatments during the study period."	Participants will be excluded from the study if they refer to clinical diseases that have a major impact on the functioning of the organism, such as degenerative diseases, neurological diseases, cancers, hematological, pulmonary, renal, hepatic and cardiovascular diseases; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-6xkcrw	Effects of positioning the newborn on the hammock in the Neonatal Intensive Care Unit to improve pain, stress and development.	Not yet recruiting	Intervention	2019-10-24	<NULL>	<NULL>	3126	Effects of Hammock Positioning in the NICU for pain relief and stress and improvement of motor development	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado de Santa Catarina	Hospital Sofia Feldman	https://ensaiosclinicos.gov.br/rg/RBR-6xkcrw	<NULL>	preterm newborn (gestational age less than 37 weeks) admitted to the intensive care unit; Low or extremely low birth weight newborn (under 2500g)admitted to the intensive care unit; chronological age greater than 24 hours of life; respiratory and hemodynamic stability; without continuous sedation and / or use of amines.	show signs or symptoms of neurological disorders; malformations; grade 2 or more of peri-intraventricular hemorrhage; severe heart disease; severe respiratory distress, immediate postoperative; phototherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-3snw7t	Influence of wearing glasses to filter blue light in the nighttime period on the perception of sleep quality and clinical parameters of critically ill patients	Not yet recruiting	Intervention	2019-10-24	<NULL>	<NULL>	3127	Influence the  blue light filter in the nighttime period on the perception of sleep quality and clinical parameters of critically ill patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3snw7t	<NULL>	The sample will be composed of patients older than 18 years; who suffered a primary event of acute myocardial infarction with or without supra-level ST tracking; hospitalized to an intensive care unit; with a minimum score of 14 points in the Glasgow Coma Scale; with a stay of at least 12 hours in the unit, without cognitive impairment; in spontaneous ventilation or using noninvasive ventilatory support	Blind patients of the quiasmatic type will be excluded. Also excluded are patients who are in Killip IV; sedata; inpatient women without the use of delayed bladder catheterization;  inincontinent men without the use of delayed bladder catheterization and who do not adapt to the use of a non-invasive device for urine collection (Uripen®); patients who have predictors related to sleep apnea such as: Body Mass Index (BMI) greater than  35; Score greater than 10 on the Epworth daytime sleepiness rating scale; Snoring; witnessed apneas; wheezing that suffocates the night; unfavorable clinical outcome (hemodynamic and respiratory instability); confirmed diagnosis of sleep apnea and patients who were discharged during data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:17
RBR-42nhd6	Human studies to evaluate the effect and safety of passion fruit peel extract on reducing high blood pressure	Not yet recruiting	Intervention	2019-10-25	<NULL>	<NULL>	3135	Clinical phase II assessment to assess the effectiveness, safety and tolerability of the peel extract of Passiflora edulis in the reduction of blood pressure in patients with Arterial Hypertension stage I	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2019-07-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-42nhd6	<NULL>	both sexes; age between 18 and 60 years; distolic arterial pressure between 90 and 99 mmHg in the mean of two measurements with a 5-minute interval in the sitting position on the right brachial artery using a sphygmomanometer; systolic blood pressure lower than 160 mmHg;  never had treatment for hypertension; agree to participate in the study with the signature of the TCLE	secondary hypertension; diagnosis of fasting diabetes or glycemia greater than 120 mg/dL; kidney disease with creatinine&gt; 2 times the upper limit of normal; obesity defined by a body mass index&gt; 30 kg / m2; endocrine diseases (hyperaldosteronism, hypercortisolism, hyperthyroidism, pheochromocytoma); liver disease with ALT or AST&gt; 2 times the upper limit of normal; peptic ulcer in the last 3 months; severe respiratory failure; hemorrhagic disease; Neoplasia and user of intravenous substances; pregnant or nursing women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-38krf2	Exercise and pain education in individuals with chronic pain	Not yet recruiting	Intervention	2019-10-29	<NULL>	<NULL>	3145	Physical therapy for muscle strengthening and endurance associated with pain education	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-38krf2	<NULL>	Pain for at least three months; intensity of at least 3 on the Visual Analogue Scale (VAS); clinical diagnosis of dysfunction to the musculoskeletal system; not undergoing any treatment or physical activity at the time of admission to the study	History of central lesion; cognitive disorders that compromise the understanding of the procedures or that affect motor control; cardiovascular and / or respiratory alterations that are not under clinical follow-up or that compromise the exercise; surgical procedure in the area of pain; pregnant women; malignant tumor; absolute contraindication to general exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-78vysg	Clinical trial for the subcutaneous recombinant human erythropoietin biosimilar in healthy adult male population	Not yet recruiting	Intervention	2019-10-30	<NULL>	<NULL>	3152	Phase I, monocentric, open-label clinical trial to determine the pharmacokinetics and pharmacodynamics of subcutaneous recombinant human erythropoietin in healthy adult male population	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-02-10	Laboratório Daudt Oliveira Ltda.	CAEP - Centro Avançado de Estudos e Pesquisas	https://ensaiosclinicos.gov.br/rg/RBR-78vysg	<NULL>	Informed Consent Form approved by IRB signed; male; age between 18 and 55 years; be characterized as a healthy research participant from medical history, general physical examination and vital signs, laboratory tests and ECG indicating no evidence of disease; have a BMI equal or greater than 18 and equal or less than 29.9 kg/m2; have a body weight of 60 - 100 kg; normal iron metabolism tests	Cardiovascular disorders and BP greater than 145/90 mmHg; history of venous thrombosis; presence of iron deficiency anemia or clinical history of autoimmune or hereditary anemia; clinical history of chronic or acute bleeding in the 30 days before the start of the trial; prior erythropoietin therapy; signs or clinical history of spinal cord aplasia; changes in the electrocardiogram that, at the physician&apos;s discretion, does not recommend the participant&apos;s stay in the trial; have a history of excessive alcohol consumption for at least 6 months prior to the trial (drinking 5 or more alcoholic beverages in one day or 15 or more alcoholic beverages per week); be a smoker or have quit smoking for less than 6 months; participant who consumes 5 or more cups of tea or coffee per day and cannot abstain during the trial period; participants with chronic diseases; hypersensitivity or contraindication of using the components of the medications studied; blood donation (more than 500 mL) or major surgery within 3 months prior to signing the Informed Consent Form; participation in clinical trial protocols in the last 12 months; any clinical condition or laboratory abnormality which, at the discretion of the investigator, could compromise trial participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:18
RBR-22qrch	Assessment of irritability and sensitization of health products through (patch test)	Not yet recruiting	Observational	2019-11-01	<NULL>	<NULL>	3162	Assessment of thermal irritability, accumulation and sensitization of health products by patch test _ mklab	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-25	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-22qrch	<NULL>	"Healthy skin in the study region; Age 18 to 65 years; Gender: male and female; Participants with phototypes I, II, III and IV (according to the Fitzpatrick classification); No history of irritation / allergy to the material used in the study; Having signed the Informed Consent Form (ICF);
Participants wishing to participate in the study without financial gain. They will be reimbursed for test-related expenses such as transportation and food"	"Participants who refuse to participate in the study in question.
Skin tags in the experimental area that interfere with the evaluation of possible skin reactions;
Active dermatoses (local and widespread) that may interfere with the study results;
Pregnant or lactating women;
History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines;
Volunteers with a history of allergy to the material used in the study;
History of atopy;
History of conditions aggravated or triggered by ultraviolet radiation;
Carriers of immunodeficiencies;
Kidney, cardiac or liver transplantation;
Prediction of intense sun exposure or tanning session during the study period;
Prediction of bathing in the sea, pool or sauna during the study;
Participants who practice water sports;
Use of the following systemic topical drugs: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection;
Treatment with acidic vitamin A and / or its derivatives orally or topically within 1 month before the start of the study;
Expected vaccination during the study or up to 03 weeks before the study;
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Included participants are advised not to change diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7sgsn5	Comparison of two techniques of separation of the Lingual Frenulum	Not yet recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3164	Comparative analysis between two Lingual Frenotomy surgical techniques	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-20	Universidade do Extremo Sul Catarinense (UNESC)	Universidade do Extremo Sul Catarinense (UNESC)	https://ensaiosclinicos.gov.br/rg/RBR-7sgsn5	<NULL>	Infants who have ankyloglossia and will be submitted to lingual frenotomy. In the Criciúma macroregion.	Infants aged six months or more; presence of other congenital malformations; prematurity; genetic syndromes; and mild ankyloglossia. Conditions that make it impossible to perform surgery; or the refusal of those responsible for the research participation. Patients with relapsed ankyloglossia. No signature of the TCLE.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-4m2xk8	Restorative Treatment versus Dental Sealants in the Posterior Permanent Teeth: A Randomized Controlled Trial	Not yet recruiting	Intervention	2019-11-01	<NULL>	<NULL>	3166	Conservative Treatment of Caries Lesions in Posterior Permanent Teeth: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal do Rio Grande do Sul - UFRGS	Universidade Federal do Rio Grande do Sul - UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-4m2xk8	<NULL>	Healthy volunteers; both genders; from 12 years of age; premolars and / or permanent molars; at least one occlusal surface active caries lesion with radiographically radiolucent in the external dentin (limited to 50% in depth); cavity width that does not contra indicate sealing; absence of previous restorations on any face of the tooth.	Patients with systemic diseases that may influence their oral health; orthodontic  pacients or teeth-fixed devices selected for the study; advanced periodontal disease with poor prognosis for tooth maintenance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8qwnjg	Effects of Respiratory Physiotherapy in individuals with Kidney Disease	Not yet recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3167	Effects of Respiratory Muscle Training and Peripheral in the physical fitness of individuals with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Universidade Metodista de Piracicana	Universidade Metodista de Piracicana	https://ensaiosclinicos.gov.br/rg/RBR-8qwnjg	<NULL>	Will be included participants from 20 to 69 years, who have stage V (five) CKD; HD treatment for at least three months, three times a week; with hemodynamic stability; able to perform the evaluations and proposed training and agree to participate in the study.	Obese individuals (BMI Bigger or equal 30Kg / m2) who have a history of lung disease, decompensated heart disease, musculoskeletal and / or neuromuscular disorders that preclude the test will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-8mj2qf	Homeopathy on primary care of cocaine-related disorders	Not yet recruiting	Intervention	2019-11-06	<NULL>	<NULL>	3168	Homeopathy on primary care of cocaine-related disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-21	Prefeitura do Município de Itajaí	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-8mj2qf	<NULL>	Assist score for cocaine between 4 and 26.	Negative urinary benzoilecgonine detection (&lt; 150 ng/mL).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-7p6vsr	Effectiveness of an Educative Booklet in promoting healthy lifestyle for people with HIV/Aids	Not yet recruiting	Intervention	2019-11-11	<NULL>	<NULL>	3178	Development, validation and effectiveness of an Educative Booklet in promoting healthy lifestyle in the context of Arterial Hypertension for people with HIV/Aids	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal do Ceará	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-7p6vsr	<NULL>	People with HIV/Aids; of both genders; with age above 18 years; accompanied in the outpatient clinic of infectology of Walter Cantídio University Hospital; in use of antiretroviral drugs for at least 6 months; who are able to read and understand the booklet according to the Health Literacy Scale.	Pregnancy; mental illness and medical diagnosis in medical records; be homeless, collective shelters or deprived of their liberty in penitentiaries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-52bw3b	Treatment of Advanced Vaginal Prolapse: Prospective, Randomized Study	Not yet recruiting	Intervention	2019-11-12	<NULL>	<NULL>	3180	Up Hold x Splentis in the treatment of advanced Pelvic Organ Prolapse: Prospective and Randomized Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Maternidade Escola Vila Nova Cachoeirinha	Hospital Maternidade Escola Vila Nova Cachoeirinha	https://ensaiosclinicos.gov.br/rg/RBR-52bw3b	<NULL>	Adult women, over 45 years old,constituted offspring, with stage III or IV advanced pelvic organ prolapse, treated at a single referral center, at Hospital Municipal e Martenidade Escola - Dr Mário de Moraes Altenfelder Silva - Vila Nova Cachoeirinha.	Vaginal, cervical or uterine cancer; Genital system or urinary tract infection; During pregnancy; Sensitivity or known allergy to polypropylene; Hypertrophic uterine cervix; Pelvic Radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:19
RBR-3c7rt3	Effects of different types of Aerobic Exercise and Weight Training protocols combined on adult health indicators with Obesity	Not yet recruiting	Intervention	2018-02-07	<NULL>	<NULL>	3198	Effects of different Concurrent Exercise Training protocols in health indicators of Obese adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-26	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3c7rt3	<NULL>	"To be voluntary;
Have BMI greater than or equal to 30kg / m²;
Having a minimum and maximum age of 20 and 50,
respectively;
To present medical certificate releasing him to practice physical exercises;
To present an electrocardiogram performed in the last year;
Not being engaged in physical exercise programs since the last 3 months;
Do not be a smoker;
Do not drink alcohol in excess (5 doses at a time)."	"Have the BMI greater than 39.9kg / m2;
Have a diagnostic of some other chronic disease;
Have any physical, visual, auditory, motor or cognitive deficiency;
Use of any medication for the control and / or treatment of obesity;
Have performed some surgical procedure aiming the weight reduction."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-2jq26n	Effects of electric current treatment on diabetic foot healing	Not yet recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3206	Effects of therapeutic resources on vascularization and healing of diabetic foot	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2jq26n	<NULL>	Patients of both sexes aged 40 years and over; with type II diabetes mellitus who have vascular and / or neurological complications in the lower limb due to diabetes mellitus.	Patients with diabetes who have lower limb amputation; some psychiatric disorder that may not understand and opt for their participation in the study; active infectious processes; decompensated hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-8rgwcq	Resistive Training in Coronariopathy with Diastolic Dysfunction	Not yet recruiting	Intervention	2019-11-21	<NULL>	<NULL>	3209	Progressive Resistive Training combined with Inspiratory Muscle Training in Coronariopathy with Diastolic Dysfunction: Clinico-functional cardiovascular outcomes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-28	Hospital Universitário Maria Rosa Pedrossian	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8rgwcq	<NULL>	Patients of both sexes; Age between 35 and 75 years old; Patients with chronic coronary artery disease by clinical and angiographic criteria, in different degrees of diastolic dysfunction by echocardiographic criteria; Patients who are stable for more than 30 days of symptoms, in regular use of prescription drugs; Patients with HFPEF (LVEF higher than 50%) or HFREF (Ejection Fraction between 30% and 50%);Assessed patients should be able to perform transthoracic doppler echocardiography, inspiratory muscle assessment, peripheral vascular doppler, treadmill exercise cardiopulmonary exercise testing, and to respond to the Minnesota quality of life questionnaire voluntarily before and after the experimental intervention	"HF patients and EF lower than 30%; HF patients and EF higher than 30% in Functional Class IV; Recent myocardial infarction (less than 30 days), unstable angina (more than 30 days) or sustained complex ventricular arrhythmia; Severe valvulopathies with surgical indication; Uncontrolled SAH: systolic BP higher than  190 mmHg  or diastolic BP higher than 120 mmHg;
Inability to exercise on a treadmill due to severe neuromuscular, neurological, orthopedic or psychological limitation; Patients without echocardiographic criteria of diastolic dysfunction by either pulsed or tissue Doppler; Patients with nonobstructive coronary insufficiency or nonatherosclerotic coronary heart disease"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:21
RBR-8sv2kp	Study on the use of Cefixime for the treatment of syphilis in Brazil	Not yet recruiting	Intervention	2019-04-26	<NULL>	<NULL>	3236	Trial evaluating the clinical efficacy of cefixime for treatment of early syphilis in non-pregnant women	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-8sv2kp	210	"Female, 18 years of age or older; non-pregnant; able to provide informed consent; test positive for syphilis with a positive TPPA and an RPR titer equal to or greater than 1:8; non-cephalosporin allergic; non-penicillin allergic; agree to be called once a day by study staff to be reminded to take study drug; able to swallow pills; willing to attend follow-up visits at 3, 6, and 9 months after completion of the study treatment; willing to take oral contraceptive or use condom to prevent pregnancy during the
study period; HIV negative"	Female under 18 years of age; HIV positive; pregnancy test positive or clinical pregnancy; prior history of syphilis or syphilis treatment within 6 months of study screening; allergy to penicillin or cephalosporins (including allergy to cefixime); in the judgment of the interviewer, has a medical condition or other factor that might affect their ability to follow the protocol; previous enrollment in the study; presenting a condition that would not allow reliable informed consent (alcohol abuse or substance misuse); lacking mental capacity to give informed consent to participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9vsnz4	Analysis of the implantation of the home mechanical ventilation on the better at home program	Not yet recruiting	Observational	2019-12-02	<NULL>	<NULL>	3238	Analysis of the implantation of the home mechanical ventilation (VMD) in services of the better at home program	<NULL>	3, n/a, n/a	3	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Alemão Oswaldo Cruz	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-9vsnz4	<NULL>	Home care services that possess the minimum conditions of admission of patients in invasive ventilation; Patients in invasive mechanical ventilation, regardless of age and cause that led to chronic ventilation, with conditions to receive care at home; services, patients and caregivers who agree to participate in the study.	Home care services that are not interested in participating in the study; home care services that do not have the minimum structure for the safe dehospitalization of patients in mechanical ventilation; refusal of the patient and/or family member to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:22
RBR-9d78qy	Effect of gum treatment in hypertensive patients	Not yet recruiting	Intervention	2019-11-19	<NULL>	<NULL>	3253	Effect of non-surgical periodontal Treatment in patients with periodontitis and Refractory Arterial Hypertension	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-9d78qy	<NULL>	Patients over 35 years old; Have at least 12 teeth present; Diagnosis of generalized periodontitis according to periodontal classification: insertion loss in 2 non-adjacent interproximal sites, clinical insertion loss (CIN) greater than or equal to 3mm in 2 teeth, except for: gingival recession, dental caries, endoperiodontal injury, occurrence root fracture, presence of loss of insertion in the distal face of a second molar and associated with poor positioning or extraction of the third molar; a gingival condition would be described as localized when less than 30% of the teeth are affected; greater than 30% of teeth are affected by periodontal disease; Patients diagnosed with major refractory arterial hypertension equal to 140 and / or 90mmHg.	Smokers or former smokers less than 12 months old; Patient with anemia; Active cancer patient; Patient with blood disorders; Pregnancy; Patient with chronic kidney disease; Patient with decompensated Type II Diabetes Mellitus; Bacterial endocarditis; Having received some kind of prior periodontal therapy; Patient using any medication such as antibiotic or anti-inflammatory and systemic conditions that affect the progression or periodontal treatment; Patient undergoing chemotherapy and / or head and neck radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-24vtrb	Effectiveness of nursing intervention to prevent falls in the elderly	Not yet recruiting	Intervention	2019-12-05	<NULL>	<NULL>	3254	Effectiveness of a nursing intervention instrument for fall prevention in hypertensive elderly	<NULL>	n/a, single-arm-study, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-02	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-24vtrb	<NULL>	Elderly with systemic arterial hypertension; have Nursing Diagnosis Risk of falls; being accompanied and registered at the Basic Health Unit I, headquarters II or Boa Fé; have an age greater than or equal to 65 years or greater than or equal to 75 years; live with a partner or family members.	Elderly with diabetes mellitus; have some mental disorder; elderly traveling on the day of recruitment of the survey participants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8pfq8c	Functional exercise program associated with neuromodulation in pain, physical abilities and quality of life of patients with fibromyalgia.	Not yet recruiting	Intervention	2019-12-10	<NULL>	<NULL>	3263	tDCS Associated Functional Exercise Program in pain, functional Performance and quality of Life of Fibromyalgia Patients: Randomized, placebo-controlled, Double-Blind Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Monayane Grazielly Leite Matias	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8pfq8c	<NULL>	Being a woman diagnosed with fibromyalgia in the age group between 30 and 70 years old; present availability to attend the intervention; not hypersensitive to electric current; have not had previous treatment with tDCS; have not performed regular exercise in the last 3 months; and have a medical certificate allowing the practice of exercise.	Presence of epileptic disease, history of seizure, psychiatric disorders, presence of rheumatic disease, except Fibromyalgia; pregnancy, metallic brain implant; at any time and for whatever reason express a desire to leave the study; missing during the ETCC protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:23
RBR-8mdyhd	Evaluation of the efficacy of listening to music on anxiety, blood pressure, heart rate, respiratory rate, oxygen saturation and pain after cardiac surgery: a randomized clinical trial.	Not yet recruiting	Intervention	2019-12-10	<NULL>	<NULL>	3270	Effect of musical hearing on anxiety, pain and cardiorespiratory parameters in cardiac surgery: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8mdyhd	<NULL>	Patients undergoing elective cardiac surgery by median longitudinal sternotomy during the data collection period.	Patients who are unable to maintain dialogue with the researcher; who have deficit or hearing and / or cognitive impairment; who are using sedative or anxiolytic medications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-86xv46	Effects of a school intervention on adolescent health	Not yet recruiting	Intervention	2019-12-11	<NULL>	<NULL>	3273	Effects of a school-based intervention on executive function, sedentary behavior and nutritional status of adolescents	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Departamento de Saúde Coletiva da Universidade Federal do Rio Grande do Norte	Departamento de Saúde Coletiva da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-86xv46	<NULL>	State public schools that work with elementary school from 7th to 9th grade; Have spaces for the practice of physical activities, such as courts and gyms; Adolescents between 12 and 16 years old and properly enrolled.	Physical disability; Intellectual disability; Endocrine disorders; Cardiovascular disease; Diabetes mellitus; Be pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-7mz2kr	Effects of multicomponent exercise program in the group and/or  at home in community-dwelling older adults	Not yet recruiting	Intervention	2019-12-12	<NULL>	<NULL>	3283	Effects of center and/or home-based multicomponent exercise program in community elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7mz2kr	<NULL>	60 years of age and over; not participating in an exercise program for 6 months prior to project participation	Physical restrictions to perform the tests and/or exercises; cognitive deficits based on the Mini-Mental State Examination scores adjusted by educational level; medical contraindications for participation in exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:24
RBR-3b2g2y	Different semantic frequencies of pelvic floor muscle training for women with stress urinary incontinence	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3305	Different weekly frequencies of pelvic floor muscle training for women with stress urinary incontinence: a ramdomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Universidade Federal de São Carlos	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-3b2g2y	<NULL>	Being a woman (biological); Age 18 years and over; complain of stress urinary incontinence determined by the affirmative response to involuntary urine loss associated with coughing, sneezing, exercise or weight lifting in the last month.	Latex allergy; vaginal or urinary tract infection; virginity; being in the gestational period; being in the puerperal period; complain of neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-66nq5z	Prevention of skin lesions due to positioning during surgery	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3306	Prevention of skin lesions by surgical positioning: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Triângulo Mineiro	Programa de Pós-Graduação strictu sensu em Atenção à Saúde	https://ensaiosclinicos.gov.br/rg/RBR-66nq5z	<NULL>	Patients who are in preoperative elective surgery, lasting longer than 120 minutes and supine dorsal position.	Patients who present skin lesion in the preoperative evaluation; patients unable to measure weight and height; local anesthesia; ASA IV and V and / or have limb amputation; change in decubitus during the surgical procedure or intraoperative complications (death or severe hypotension).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-5jm6gw	Evaluation of gynecological and dermatological acceptability of health product under normal use, with PH measurement	Not yet recruiting	Observational	2019-12-05	<NULL>	<NULL>	3308	Evaluation of gynecological and dermatological acceptability of health product under normal use, with measurement of PH, microbiota and Swab collection	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-25	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-5jm6gw	<NULL>	Women; Age 18 to 65 years; Phototype I to IV; Whole skin of the region; Occasional user of category products	"Skin markings in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, ephelides and nevus in large quantities, sunburn);
Pregnant or lactating women;
Participants with a history of allergy to the material used in the study;
History of atopy;
Use of vaginal cream;
Participants with a history of allergy to products of the tested category;
Recent gynecological surgeries;
Discharge;
Carriers of immunodeficiencies;
Kidney, cardiac or liver transplantation;
Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis)
o Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.
Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Participants included are advised not to change their diet, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8gpgyd	Teleconsultation study in diabetic patients	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3310	Pragmatic, unicentric, open-label, phase 2, non-inferiority, randomized controlled trial to evaluate the efficacy and safety of teleconsultation compared to face-to-face consultation of patients with Diabetes Mellitus referred from primary care to specialized care in the single health system	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-12-01	Hospital Alemão Oswaldo Cruz	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8gpgyd	<NULL>	Adult patients, both sexes, older than 18 years; diabetic patients, regardless of priority, according to the protocol defined in the study; patients diagnosed with type 2 diabetes mellitus, with any level of glycemic control measured by glycated hemoglobin and/or fasting glucose, who meet criteria for referral from primary care to specialized care; patients on insulin with glycated hemoglobin greater than 8	Patients under 18 years of age and Type 1 diabetes mellitus; patients with gestational diabetes mellitus or diagnosed during pregnancy; Patients with estimated or measured creatinine clearance below 30 ml / min / m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-8wjq29	Evaluation of Isoniazid 300 mg Drug for the Treatment of Latent Tuberculosis Infection in Brazil	Not yet recruiting	Intervention	2019-12-27	<NULL>	<NULL>	3314	Evaluation of Isoniazid 300 mg Implementation for the Treatment of Latent Tuberculosis Infection in Brazil	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Universidade Federal do Espirito Santo	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-8wjq29	<NULL>	Patients who agree with the consent form; Patients of both sexes; Indication for treatment with isoniazid 300mg per day; With access to mobile smartphone with Android operating system; patients who know or not read; age between 18 and 50 years;	Patients on treatment for rifampicin or already on treatment for latent tuberculosis; patients with HIV; pregnant or intending to become pregnant; homeless patients; deprived of liberty; Patients referred for treatment over 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:25
RBR-2s4tpw	Effects of phototherapy on pressure ulcers	Not yet recruiting	Intervention	2020-01-02	<NULL>	<NULL>	3319	Effects of photobiomodulation on pressure injury stages 2 and 3 clinical controlled randomized blinded study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	São Paulo Secretaria da Saúde	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2s4tpw	<NULL>	Participants over 18 years. Both sexes. With pressure injury stages 2 or 3. Length of stay 15 days.	Participants with active neoplasms or palliative care; osteomyelitis in the wound region or with stage 1 or 4 pressure injuries. Deep tissue injury; unclassifiable lesions; complex wounds, necrotic; infected  will be excluded. Patients with a history of photosensitivity to photonic therapy or who have significant neurological or psychiatric disorders will also be excluded from the study as it compromises assessments of uncoupling or pain during photobiomodulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-4xgwxb	A pilot study for care for trans men	Not yet recruiting	Observational	2020-01-03	<NULL>	<NULL>	3325	Humanization of trans men`s care: A pilot study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Mauro Schechter	Projeto Praça Onze	https://ensaiosclinicos.gov.br/rg/RBR-4xgwxb	<NULL>	female gender (at birth); Able to provide written informed consent;Aged 18 to 65 years older; Identify with the male Use of masculinizing hormones	male gender at birth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-6vbsmb	Clinical efficacy of distance exercises associated with professional telephone follow-up for patients with neck pain	Not yet recruiting	Intervention	2020-01-06	<NULL>	<NULL>	3327	Effect of a telerehabilitation exercise protocol in subjects with chronic neck pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6vbsmb	<NULL>	Participants between the ages of 18 and 65 years, neck pain for at least 3 months, with or without radiating pain, no history of significant injury to the neck or upper thoracic spine (car accident), experiencing pain during the physical exam.	Patients will be excluded if they had undergone cervical spine surgery or cervical spine stenosis, reported neurological signs, severe pain (&gt;7/10) during muscle strength measurements, rheumatic and/or inflammatory diseases (ankylosing spondylitis, rheumatoid arthreitis), cervical instability, spinal cord involvement or congenital diseases affecting the musculoskeletal system, major psychological disease (severe depression or mental disorder), pregnancy, and any intervention that included exercise or physical therapy in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:26
RBR-8xcxdf	Effect of exercise on aldosterone, cardiovascular variables in patients with renal disease	Not yet recruiting	Intervention	2020-01-14	<NULL>	<NULL>	3359	Effect of home-based exercise on aldosterone, ventricular mass, arterial stiffness in hemodialysis.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8xcxdf	<NULL>	Age greater than or equal to 18 years; both sexes; with CKD in hemodialytic treatment for a period of more than or equal to 3 months; plasma Aldo above 15 ng / dL; do not present contraindications for performing physical activity.	Patients with cognitive deficits, diagnosis of psychiatric disorders; amputees; pregnant women and non-literates; with a previous diagnosis of coronary artery disease; patients considered to be active or very active according to the IPAQ questionnaire, chronic uncontrolled arterial hypertension with BP of 160/100 mm Hg, positive exercise test for cardiac ischemia; patients who suffered a stroke and / or acute myocardial infarction, neoplasia patients; hepatic insufficiency and patients receiving; spironolactone, occurrence of active infection; change in class and / or drug dose; use of antihypertensives; including use of spironolactone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-9t7zvt	The effects of music education program of guri santa marcelina in São Paulo	Not yet recruiting	Intervention	2020-01-15	<NULL>	<NULL>	3361	The effects on cerebral structure, social, and cognitive abilities on children exposed to guri santa marcelina program  at greater sao paulo: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Universidade estadual paulista júlio de mesquita filho	Associação de Cultura, Educação e Assistência Social Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-9t7zvt	<NULL>	50 six and seven year old children from the experimental group exposed to the Guri Santa Marcelina Program; 100 six and seven year old children from the control group who attend schools at the same communities as the experimental group of children	Children with the percentile 5 of the Raven Color Progressive Matrices test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-5bw2wt	The role of the pharmacist in the team care of hospitalized patients with Chronic Brochitis or Emphysema	Not yet recruiting	Intervention	2012-05-01	<NULL>	<NULL>	3362	Pharmaceutical care Programme for inpatients with Chronic Obstructive Pulmonary Disease in a Tertiary Teaching Hospital in Southern Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-01	Hospital de Clínicas de Porto Alegre - UFRGS	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5bw2wt	<NULL>	Inpatients with exacerbation of COPD  at HCPA.	difficulty of understanding (absence of response to verbal commands, severe psychiatric illness, retardation, blindness), psychiatric illness with corresponding CID; metastatic desease; decompensated severe heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-98hj9x	Applications of Physioterapy Equipments in Low Back Pain	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	3369	Application of Electrothermalphototerapeutic Current in patients with Lumbar Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-98hj9x	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	Participants who have had surgery in the lower back; gives; not presenting back pain radiated to the buttocks and lower limbs, alteration of thermal and / or sensory sensitivity, pregnant women, kidney problems; patients with pacemakers; skin lesions; use of medication for lumbar pain relief 48 hours before the application of the technique. do not have clinical diagnosis of low back pain and when the etiology of back pain is unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-4pgn3c	Applications of one Physioterapy Equipment in Low Back Pain	Not yet recruiting	Intervention	2020-01-15	<NULL>	<NULL>	3374	Aussie current application in low back pain patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4pgn3c	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than 3 ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	Participants who have had surgery in the lower back;  not presenting back pain radiated to the buttocks and lower limbs, alteration of thermal and / or sensory sensitivity, pregnant women, kidney problems; patients with pacemakers; skin lesions; use of medication for lumbar pain relief 48 hours before the application of the technique. do not have clinical diagnosis of low back pain and when the etiology of back pain is unknown.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:27
RBR-3crsfj	Clinical trial to compare the efficacy and safety between the combination of dorzolamide hydrochloride (2%) + brimonidine tartrate (0.2%) + timolol maleate (0.5%) and COMBIGAN® (combination of 0.2% brimonidine tartrate + 0.5% timolol maleate) in reducing ocular pressure in adult patients with primary open-angle glaucoma or high pressure in the eyes	Not yet recruiting	Intervention	2020-01-20	<NULL>	<NULL>	3381	Phase III, multicenter, double-blind, randomized, controlled, 12-week, parallel-group, superiority trial to compare the efficacy and safety of the triple fixed combination of dorzolamide hydrochloride (2%) + brimonidine tartrate (0.2%) + timolol maleate (0.5%) versus COMBIGAN® (double fixed combination of 0.2% brimonidine tartrate + 0.5% timolol maleate) in reducing intraocular pressure (IOP) in adult patients with primary open-angle glaucoma or ocular hypertension	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-06-01	Laboratório Daudt Oliveira Ltda.	Centro de Pesquisa Clínica São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-3crsfj	<NULL>	Men or women aged 18 years-old or over; having a diagnosis of primary open-angle glaucoma or ocular hypertension; being able to sign the ICF approved by IRB and to execute and understand all study procedures and instructions; having intraocular pressure greater than or equal to 21 and less than or equal to 30 mmHg in, at least, one eye; having an optical disc excavation of 0,8 or less	"Presenting blindness in one eye; having visual acuity worse than or equal to 20/40 in either eye without justified cause; presenting a history of any concomitant active-stage eye disease, except those specified in
inclusion criteria; for participants taking medication to treat primary open-angle glaucoma or ocular hypertension may only participate in the study if they discontinue the drug for a period of up to 7 (± 2) to 30 (± 2) days, according to the therapeutic class of the medication used; making use of topical corticosteroids ophtalmic or topical within
14 days from the screening visit. It is prohibited the use of systemic corticosteroids and psychotropic medicines with adrenergic potential (eg desipramine, amitriptyline) within 1 month of the screening visit or any other medication which, regardless of the route of administration, interfere with the study results and offer a risk to the participant&apos;s safety, at the investigator&apos;s discretion, used within 48 hours prior to the screening visit or until residual effects may be present; having an allergy to sulfa drugs; having hypersensitivity to the active ingredients and excipients of the study medications; wearing contact lenses 7 days before the screening visit (pre-treatment) and throughout the study; current history of bronchial asthma or chronic obstructive pulmonary disease (COPD), sinus bradycardia, 2nd or 3rd degree heart block, heart failure, cardiogenic shock; current or previous history of severe renal or hepatic impairment,
current history of diabetic retinopathy or any other clinical condition that, at the investigator&apos;s discretion, contraindicates participation in the study or interferes with the study outcome; participants of childbearing age who do not agree to use a
adequate form of contraception; pregnant, nursing women who plan to become pregnant, or who have a positive pregnancy test on their blood test; having a history of cataract surgery with or without intraocular lens (IOL) implantation (pseudoaphakia or aphakia) within 3 months or less prior to the screening visit; having a recent history of alcohol and/or drug abuse or excessive alcohol consumption; presenting corneal abnormalities that interfere with an accurate reading of intraocular pressure by a Goldmann applanation tonometer; being part of a clinical study within the last 12 months unless, at the discretion of the investigator, it represents a benefit to the participant"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-2vkjzp	Analysis of jaws position in orthognathic surgery using zygomatic supported guides	Not yet recruiting	Intervention	2020-01-20	<NULL>	<NULL>	3383	Accuracy analysis of jaws position in orthognathic surgery using intermediate guides supported on zygomatic bones	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-02-10	Obras Sociais Irmã Dulce	Obras Sociais Irmã Dulce	https://ensaiosclinicos.gov.br/rg/RBR-2vkjzp	<NULL>	Individuals over than 18 years; without comorbidities; with facial deformities; with indication for maxillomandibular surgery for correction	Individuals requiring isolated surgery of the maxilla or mandible;individuals with diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8k2928	Palbociclib plus letrozole treatment for women  ovarian cancer	Not yet recruiting	Intervention	2020-01-21	<NULL>	<NULL>	3387	Palbociclib plus letrozole treatment for women with ER/PR-positive ovarian cancer after progression to second line chemotherapy	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2019-12-02	Latin American Cooperative Oncology Group	Latin American Cooperative Oncology Group	https://ensaiosclinicos.gov.br/rg/RBR-8k2928	<NULL>	"Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study;subject is willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures; eighteen years of age or older; patient agrees not to participate in another interventional study while on treatment; histologically diagnosed endometrioid or high-grade serous ovarian cancer, estrogen and or progesterone receptor positive, defined as more than ten percent by immunohistochemistry;
NOTE: The ER and PR status must be centrally reviewed before treatment allocation. Patients must have completed two previous courses of chemotherapy: The penultimate regimen must be a platinum based chemotherapy course prior to enrolment on the study: For the last chemotherapy course prior to enrolment on the study: There is no prespecified regimen; it may contain a Platinum salt or not, depending upon Platinum sensitivity, at discretion of treating Physician; patients must have demonstrated disease progression by RECIST v1.1 to the last treatment. Patients must be treated on the study within eight weeks of completion of their final dose of second line regimen; formalin fixed, paraffin embedded tumor sample from the primary tumor must be available for central testing; eastern One. Cooperative Oncology Group performance status  Two; adequate bone marrow function at screening: Absolute Neutrophil Count 1,500 to mm³. Platelets 100,000 to mm³. Hemoglobin 9.0 g to dL; adequate liver function at screening: Total serum bilirubin 1.5 x upper limit of normal, 3.0 x ULN if Gilbert Syndrome. Aspartate aminotransferase and alanine aminotransferase 3.0 x ULN, 5.0 x ULN if there is tumor involvement in the liver. Alkaline phosphatase 2.5 x ULN, 5.0 x ULN if there is tumor involvement in the liver; adequate renal function at screening: Serum creatinine 1.5 x ULN or estimated creatinine clearance 50mL to min; evidence of nonchildbearing potential: Postmenopausal, defined as at least one year without any menses, prior to screening, or radiation induced oophorectomy with last menses more than one year ago, or surgical sterilisation, bilateral oophorectomy or hysterectomy."	Patients with a known hypersensitivity to Palbociclib or Letrozole or any of the excipients of the product; previous treatment with CDK inhibitors or endocrine therapy; persistent toxicities, grade two or greater, caused by previous cancer therapy, excluding alopecia; patients with second primary cancer, except: adequately treated non melanoma skin cancer, curatively treated in-situ cancer of the cervix, Ductal Carcinoma in Situ, stage one grade one endometrial carcinoma curatively treated with no evidence of disease for three years; patients receiving any chemotherapy, radiotherapy, within three weeks from the last dose prior to study entry; patients with symptomatic uncontrolled brain metastases. A scan to confirm the absence of brain metastases is not required; major surgical procedure within three weeks prior to study randomization, or one is planned during the course of the study; patients considered poor medical risk due to a serious, uncontrolled medical disorder, non malignant systemic disease or active, uncontrolled infection. Examples include, but are not limited to, uncontrolled ventricular arrhythmia, recent, within six months, myocardial infarction, cerebrovascular accident, gastrointestinal bleeding, or any psychiatric disorder that prohibits obtaining informed consent; patients that have difficulty taking oral medication or any digestive tract dysfunction or inflammatory bowel disease that would interfere with the intestinal absorption of drugs, eg, partial bowel obstruction or malabsorption; patients have received potent inhibitors or inducers of CYPthreeAfour within seven days prior to randomization; pregnant or breast feeding women; patient has a known history of positive test for human immunodeficiency virus; patients with known hepatic disease, ie, Hepatitis B or C; subjects who are investigational site staff members directly involved in the conduct of the trial and their family members, site staff members otherwise supervised by the Investigator, or subject who are Pfizer employees directly involved in the conduct of the trial; treatment with any investigational product during the last twenty-eight days; QTc greater than 480ms, QT syndrome, Brugada syndrome, history QTc prolongation or Torsade de Points; other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-9t6rd7	Effects of sildenafil on the pulmonary microvascular disease of symptomatic smoker	Not yet recruiting	Intervention	2020-01-22	<NULL>	<NULL>	3390	Effects of sildenafil on exercise responses in symptomatic individuals with evidence of tobacco-associated pulmonary microvascular disease: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	Universidade Federal de Mato Grosso do Sul	Hospital Universitário de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9t6rd7	<NULL>	Symptomatic vascular phenotype; Individuals of both sexes; Age between 35 and 80 years; History of smoking for more than 10 years; Sinus rhythm; Preserved left ventricular ejection fraction (higher than 50%); The evaluated patients should be able to perform spirometry, carbon monoxide diffusion test and cardiopulmonary exercise test.	"Carrier of diabetes mellitus, bronchial asthma, previous myocardial infarction, heart failure, complex ventricular arrhythmias; Chronic atrial fibrillation; Body mass index lower than 18.5 or higher than 35 kg per m²; Anemia with hemoglobin lower than 11 g% in women and lower than 12 g% in men; Chronic hypoxemia of undetermined cause; neuromuscular, orthopedic or psychological limitation;
Contraindication to the use of sildenafil citrate or previous use of it thereof."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-9jgq9c	Evaluation of gynecological, proctological and dermatological acceptability of product for health under normal conditions of use	Not yet recruiting	Observational	2020-01-22	<NULL>	<NULL>	3391	Evaluation of gynecological, proctological and dermatological acceptability of product for health under normal conditions of use_mklab	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-27	Labterapi Laboratório de produtos naturais EIRELI EPP	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-9jgq9c	<NULL>	Women; Age 18 to 65 years; Phototype I to IV; Whole skin of the region; Occasional user of category products	"Skin markings in the experimental area that interfere with the evaluation of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; History of atopy; Use of vaginal cream; Participants with a history of allergy to products of the tested category; Recent gynecological surgeries; Discharge; Carriers of immunodeficiencies; Kidney, cardiac or liver transplantation; Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before study start; Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study.
Note: Participants included are advised not to change their diet, exercise routine and contraceptive method. Also, not using products in the same category as the product tested in the experimental region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-76zy82	The effect of nursing interventions with families for children care who performed scheduled surgeries	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3399	Effectiveness of family nursing interventions for children care undergoing elective surgeries: a randomized controlled superiority trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de São Paulo, Escola Paulista de Enfermagem	Universidade Federal de São Paulo, Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-76zy82	<NULL>	Neonates, infants, preschoolers and schoolchildren;Presence of at least one family member over 18 years old during family meetings with the nurse who will perform the intervention;Expected hospital stay of 72 hours or more;Patient undergoing elective surgeries including cardiac, gastrointestinal, urological, genitourinary	Illiterate family member (s), without command of the Portuguese language, with any psychic, physical and / or cognitive disorder that makes verbal communication difficult;Death of the child during the study period Children with diseases or comorbidities that lead to neurological, motor, muscle, functional and disabling disabilities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-8z86dk	Effects of Ozone  and Physiotherapy on the treatment of Rheumatoid Arthritis of the hands	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3401	Effects of Ozone Therapy and Kinesiotherapy on the treatment of Rheumatoid Arthritis of the hands	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-28	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-8z86dk	<NULL>	"Individuals aged 18 and over; People of both sexes;Patients diagnosed with hand 
rheumatoid arthritis."	Individuals with severe neuromotor sequelae; Patients unable to verbalize or perform the proposed tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-6qjtb4	Effect of Tibial Nerve Stimulation in patients with Urinary Incontinence after surgery to Remove the Prostate	Not yet recruiting	Intervention	2020-01-27	<NULL>	<NULL>	3402	Percutaneous Tibial Nerve Stimulation in patients with Urinary Incontinence after Prostatectomy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-17	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6qjtb4	<NULL>	Men who underwent radical prostatectomy with urinary incontinence after the cateter removal, defined by a volume greater than 1.0 gram on the pad test and who agreed to participate in the research	Men who are using anticholinergics, tricyclic antidepressants, who have neurological disorders or urethral stricture. Men with complications such as radiotherapy will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:28
RBR-98cknq	Effects of switched  training on the health of children and adolescents with chronic diseases	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3408	Effects of Cross Over Training on the health related physical fitness of children and adolescents with chronic diseases: a randomized clinical trial.	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2019-11-20	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - FMRP-USP	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - FMRP-USP	https://ensaiosclinicos.gov.br/rg/RBR-98cknq	<NULL>	Confirmed diagnosis of chronic diseases; patient with spina bifida;Duchenne muscular dystrophy;Charcot Marie Tooth;congenital dystrophy;congenital myopathy;independent walk; use assistive device;use of wheelchair; age between 8 to 16 year old;answer no to all PAR-Q questions; have less than two risk factors for coronary heart disease from the questionnaire;patients who could develop a maximum cardiopulmonary exercise test confirmed by physician;patients able to follow the instructions;patients with voluntary participation in the research	Patients with comorbidities associated with underlying disease that prevent maximum exertion;  recent upper limb fracture;history of hydrocephalus that compromises understanding or lead to neuromuscular changes and cause motor incoordination to perform the tests;children and adolescents whose guardians do not agree to sign the Informed Consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-7y89kb	The impact of mindfulness on Quality of Life, Occupational Stress and Empathy of health professionals.	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3409	The impact of mindfulness on health professionals&apos; quality of life, anxiety, burnout levels and empathy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Pedro Henrique Leonetti Habimorad	Faculdade de Medicina de Botucatu (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-7y89kb	<NULL>	Voluntary health professionals working on the Clinical Hospital of the Botucatu Medical School (HC-FMB-UNESP); healthy	Health professionals working on administrative area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-7h834x	Combined BCAA and Omega 3 Supplementation: Clinical-Nutritional, Cardiorespiratory, Metabolic Impact and Quality of Life in Pre-Malnourished / Malnourished Patients	Not yet recruiting	Intervention	2020-01-28	<NULL>	<NULL>	3412	Combined supplementation of Ramified Chain and Omega 3 Amino Acids: clinical-nutritional, cardiorespiratory, metabolic impact and quality of life in pre-cachectic / cachectic patients	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal do Maranhão	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão - FAPEMA	https://ensaiosclinicos.gov.br/rg/RBR-7h834x	<NULL>	Uterine Cervical Cancer; Minimum age of 20 years; Stability (no changes in treatment regimen within 6 weeks or hospitalizations within 3 months); Sign the consent form.	Restricted Vegetarian; Use of pacemaker; Palliative care; Withdrawal of Consent; Accession to intervention below 75%; Allergy Nutritional Composition of Supplements; Refusal of the proposed supplementation; Significant worsening after intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-69qq9p	Biotin in the treatment of female hair loss	Not yet recruiting	Intervention	2020-01-29	<NULL>	<NULL>	3420	A 24-week randomized, prospective, triple-blinded, placebo-controlled trial investigating the efficacy of 10 mg biotin in the treatment of chronic effluvium telogen in women	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2019-07-01	Paulo Ramos	Faculdade Medicina da Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-69qq9p	<NULL>	Inclusion criteria: women between the ages of 18 and 65 who complain of increased hair loss for more than six months; daily loss of yarn equivalent to at least level 5 of the Sinclair drop scale	Clinical or dermatoscopic signs of alopecia areata, trichotillomania or cicatricial alopecias; anemia (hemoglobin less than 11 mg / dl), thyroid changes (TSH&gt; 4.0 or &lt;0.3 um/L or T4l&gt; 1.5 or &lt;0.7 ng/dl); history of any treatment for hair loss in the last 3 months; surgery, pregnancy, febrile infectious disease or suspension of contraceptive use in the last 4 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:29
RBR-97jc37	Oral assessment in autistic patients	Not yet recruiting	Observational	2020-01-29	<NULL>	<NULL>	3429	Oral condition assessment of patients with autism spectrum disorder	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-15	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-97jc37	<NULL>	Patients diagnosed with Autism Spectrum Disorder; Patients aged 5 and up to 15 years; Patients being monitored at the Center for Dental Assistance to Persons with Disabilities (CAOE).	Non-collaborating patients; Patients with unstable health condition; Patients with blood disorders; Active cancer patients; Patients in need of sedation; Patients supplemented with vitamins in the last two months; Edentulous patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-5hk245	The effect of Vitamin D use on dizziness treatment in elderly	Not yet recruiting	Intervention	2020-01-30	<NULL>	<NULL>	3432	The effect of Vitamin D supplementation on recurrence of Benign Paroxysmal Positional Vertigo in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-03	Centro Universitário de Adamantina (UNIFAI)	Centro Universitário de Adamantina (UNIFAI)	https://ensaiosclinicos.gov.br/rg/RBR-5hk245	<NULL>	Benign Paroxysmal Positional Vertigo. Hypovitaminosis D. Elderly. Both sexes.	Those who do not agree with the study&apos;s prerogative, as well as non-collaborators, will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-346ymn	Evaluation of mobile medical equipment called Tytocare that collects and sends patient data to other remote physicians for pediatric care even if they are not in contact with patients	Not yet recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3435	Mobile medical device evaluation - Tytocare - for telemedicine validation through pediatric teleinter consultation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-20	Hospital Pequeno Principe	Hospital Pequeno Principe	https://ensaiosclinicos.gov.br/rg/RBR-346ymn	<NULL>	Patients between 0 and 18 years incomplete; both sexes; attended at the SUS Emergency Service or agreement; classified in green code (low risk) in the HPP Emergency Care screening; a parent or legal guardian consents to and signs the Informed Consent Form	Patients classified in the codes red (severe patient, considered as emergency, with immediate care), orange (patient considered as urgent, with care within 15 minutes), yellow (patients who do not have conditions that characterize medical urgency, however , are identified as patients who require particular conditions for prioritization) and blue (patients who have specific procedural needs); Patients whose legal guardian or parent does not consent to participate; Patient who does not agree to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-32jnbm	Study of the effects of the fractional radiofrequency and  microneedling in long-term on the outer region of the vagina in menopausal women	Not yet recruiting	Intervention	2020-01-09	<NULL>	<NULL>	3437	Evaluation of long-term effects of fractional radiofrequency and microneedling on external genitalia in menopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	Universidade Federal do Rio Grande do Norte	Instituto Patrícia Froes	https://ensaiosclinicos.gov.br/rg/RBR-32jnbm	<NULL>	In the inclusion criteria, participants must be between 55 and 65 years of age, with flaccidity in the vulvar region, post-menopausal period of up to 5 years, who had 2 to 3 normal births, not practicing physical activity, not being able to use hormone replacement therapy and with the ability to understand and preserve local sensitivity.	Exclusion criteria will apply to all participants who are pregnant, breastfeeding 3 months before treatment or planning to become pregnant during the study period, with active sexually transmitted disease, acute bacterial or viral infection, pacemaker carriers or other implanted electrical devices, malignant tumor, weakened immune system, collagen diseases, continuously using anti-inflammatory drugs, dermatological condition that requires systemic or topical therapy in the area of treatment and metallic implants. Participants who do not agree with the procedures, have a sensitivity disorder during therapy, or do not adapt to the schedules and procedures will be discontinued from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-9hszzh	Clinical and antimicrobial effect after use of Brazilian red propolis toothpaste	Not yet recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3439	Avaliação de dentifrício de própolis vermelha brasileira sobre redução de bactérias orais e gengivite em adolescentes em tratamento ortodôntico	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9hszzh	<NULL>	Aged between 12 and 18 years; Use of fixed orthodontic appliance; Presence of visible plaque on dental surfaces; Presence of gum bleeding Be right handed	"Present systemic changes related to the periodontal health-disease process;
They underwent antimicrobial therapy (antibiotic and / or anti-inflammatory treatment) up to six months before the research;
Licit / illicit drug users;
Are prosthesis wearers;
Carriers of less than 10 dental elements per dental arch;
Patients with a history of allergies (asthma, urticaria, rhinitis, sinusitis);"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-8pd5zr	Evaluation of Glycemic Variability and Hypoglycemic Episodes in type 2 Diabetics with Important Decrease of Renal Function	Not yet recruiting	Intervention	2020-01-31	<NULL>	<NULL>	3441	Evaluation of Glycemic Variability and Hypoglycemic Episodes in type 2 Diabetics with Chronic Renal Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8pd5zr	<NULL>	Men or women over 18 years; Advanced kidney disease undergoing renal replacement therapy; Type 2 diabetes mellitus on NPH insulin treatment with or without regular insulin for at least 3 months; Glycated hemoglobin greater than 6.5%	Type 1 diabetes mellitus; hypersensitivity to research drugs; treatment with oral glucocorticoids; cancer; women of childbearing age who are pregnant or wish to become pregnant; participation in any other clinical study within the last 90 days prior to the start of this study; abuse of narcotics or alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-3dbmqs	Effectiveness and safety of a new cryotherapy vest to reduce core temperature in athletes (healthy volunteers) after aerobic activity	Not yet recruiting	Intervention	2020-02-03	<NULL>	<NULL>	3446	Effectiveness and safety of a new cryotherapy vest to reduce core temperature in athletes (healthy volunteers) after aerobic activity: Crossover Randomized Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Centro Universitário São Camilo	Centro Universitário São Camilo	https://ensaiosclinicos.gov.br/rg/RBR-3dbmqs	<NULL>	Participants of either sex aged greater than 18 years but less than 60 years; Professional or semi-professional athletes practicing physical activity at least 2x / week for more than 6 months; Signed informed consent; Completion of modified physical activity readiness (Par-Q) and global physical activity fitness (GPAQ) questionnaires; Able to use a treadmill.	Present with signs or symptoms of acute or chronic illness; Athletes with an initial core temperature less than 35.5 or greater than 37.5 °C; BMI greater than 30 kg/m2; Skin lesions evident or reported by athletes or medical staff that contraindicate participation in the study, such as purulent skin gangrene; Known joint and/or muscle injuries that contraindicate the use of a treadmill; Have contraindications to cryotherapy such as cryoglobulinemia, cold intolerance, Raynaud&apos;s disease, hypothyroidism, acute respiratory system disorder, cardiovascular disease (unstable angina or CHF class III and IV), sympathetic nervous system neuropathy, local blood flow disorders, and cachexia; Current participation in another ongoing clinical trial.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:30
RBR-557ngk	Effects of Melatonin supplementation and Physical Exercise practice on aged individuasl with Muscular Weakness	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3456	Effects of Melatonin supplementation on Sarcopenic aged individuals submitted to a Physical Exercise program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-557ngk	<NULL>	Age between 55 and 80 years; both genders; diagnosis of sarcopenia	Present an orthopedic disorder that contraindicates physical activities; cognitive disorder that makes it difficult to orient the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-53pppb	Fluoride availability in saliva after brushing with embedded Brazilian red propolis toothpaste	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3458	Evaluation of fluoride in saliva after using toothpaste incorporated with Brazilian red propolis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-20	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-53pppb	<NULL>	"Be right handed
Normosystemic
Good oral health conditions
Both genders
Aged between 12 to 18 years"	"Present systemic changes related to the periodontal health-disease process
They underwent antimicrobial therapy (antibiotic  or anti-inflammatory treatment) up to six months before the research;
Licit or illicit drug users
Are prosthesis wearers
Patients with missing teeth
Patients with a history of allergies (asthma, urticaria, rhinitis, sinusitis)
Patients with a history of hypersensitivity to medication, food or other factors
Patients with a history of chronic diseases
Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-774xbd	Effect of a homemade salivary substitute prepared with Chamomile and Linseed in relieving the burning sensation in the mouth	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3459	"Effect of a homemade salivary substitute based on Chamomile (Matricaria chamomilla) and
Linseed (Linum usitatissimum) in relieving the symptoms of Burning Mouth Syndrome"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-20	Faculdade de Odontologia Universidade Federal de Pelotas	Faculdade de Odontologia Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-774xbd	<NULL>	Women over 40 diagnosed with BMS by an oral medicine specialist according to the international classification of headache disorders; complaining of an intraoral burning sensation for more than 2 hours for more than three months; clinically normal oral mucosa; without signs of neuropathies involving other pathologies; without articular function; normal blood samples (red blood cell and leukocyte count, C-reactive protein levels, normal levels; no anemia); in the case of previous treatment for BMS it must have been included ineffective and discontinued for a minimum period of 2 months before being included in the study	Women with oral lesions or systemic diseases associated with BMS; Women in current treatment for BMS; Women with a glycated hemoglobin level (hemoglobin A1C)&gt; 7%; pregnant women; women being treated with corticosteroids; women with lesions in the oral mucosa or patients with dental prosthesis; women with anemia, Sjoegren&apos;s Syndrome or another Autoimmune Diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-78bn48	"WINE Study - Strength and flexibility
training for pain reduction and work
performance improvement"	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	3460	Effects of an exercise protocol for work-related musculoskeletal disorders on grape collectors in the São Francisco Valley	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-78bn48	<NULL>	Physically independent participants who have not participated in structured exercise programs for at least 3 months will be included in the study. In addition, absence of clinical conditions or unstable disease that contraindicates the practice of supervised physical exercise during pre-participation screening; history of lower back pain lasting more than one week; pain greater than 3 on the pain perception scale (0 to 10 points) in the lumbar spine; have no history of trauma or surgery in the lumbar spine; no spinal and knee disorders that make it impossible to perform exercises, no hypertension, cardiovascular disease, heart failure, myocardial infarction and cerebrovascular accident, are inclusion criteria.	"Performing any type of exercise for the
spine during the intervention period
or engaging in another physical activity
program; continuous use of drugs and / or
ergogenic resources that positively or
negatively interfere with performance;
participants affected by limiting health
conditions; and pregnancy during the
intervention period."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-3rh759	Development of a Health Promotion Program for patients with Fibromyalgia	Not yet recruiting	Intervention	2020-02-07	<NULL>	<NULL>	3461	Development of an Interdisciplinary Health Promotion Program for People with Fibromyalgia - Fribro&apos;s Friends	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3rh759	<NULL>	Individuals of both sexes; age equal to or over 18 years; with medical diagnosis of fibromyalgia confirmed by an evaluator according to the Classification Criteria of the American College of Rheumatology revised version of 2016; individuals with preserved speech and hearing ability.	Medical diagnosis of myofascial pain syndrome; extra-articular rheumatism affecting several areas; polymyalgia rheumatica and giant cell arthritis; polymyositis and dermatopolymyitis; tendinopathies; neuropathies; endocrine myopathies; hypothyroidism; hyperthyroidism; hyperparathyroidism; adrenal insufficiency; metabolic myopathy due to alcohol; neoplasms; spinal diseases; Parkinson&apos;s disease; pregnant and lactating women; individuals who have not taken medication for more than three months or with stable pharmacological treatment (more than 3 months); individuals who are absent more than twice in a row in the intervention group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-252w9r	Minoxidil 5 mg oral versus Minoxidil 5% topical solution for Male Pattern Baldness: randomized clinical trial	Not yet recruiting	Intervention	2020-02-09	<NULL>	<NULL>	3464	Minoxidil 5 mg oral versus Minoxidil 5% topical solution for Treatment of Male Androgenetic Alopecia: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-252w9r	<NULL>	"We will select ninety male patients aged between 18 and 55 years with the diagnosis of male androgenic alopecia, classified in the Norwood Hamilton scale as 3V, 4V or 5V, informed and agreeing to participate in the research.
The diagnosis of male androgenic alopecia will be based on clinical, dermoscopic and histopathological criteria."	Patients who have had previous hair loss treatment in the last 6 months, hypertensive patients, heart disease, nephropaths, other causes of hair loss or scalp dermatosis will not be eligible to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-97mffm	A randomised controlled trial of a smartphone application for help oral hygiene	Not yet recruiting	Intervention	2020-02-10	<NULL>	<NULL>	3469	Mobile Health (mHealth) Intervention assessment for the treatment of periodontal diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Programa de Pós Graduação em Odontologia da Universidade Federal do Rio Grande do Sul	Mirian Paola Toniazzo	https://ensaiosclinicos.gov.br/rg/RBR-97mffm	<NULL>	"To be included:
volunteers with gingivitis and periodontitis;
non smokers;
both genders;
age between 18 and 60 years;
 Individuals must have their own cell phone handset with internet access;
be literate in mHealth;
have a visible plaque percentage greater than or equal to 30%;
have a percentage of gingival bleeding greater than or equal to 30%;
Clinical insertion loss greater than or equal to 3 mm in two nonadjacent teeth;
bore depth greater than or equal to 4 mm in two or more teeth;
At least 12 teeth present."	"The following exclusion criteria will be considered: 
patients who used antibiotics or anti-inflammatory drugs in the last 6 months prior to the study; 
who have any physical condition that impairs their motor skills; 
who are wearing orthodontic braces; 
 smokers."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-2kmyfm	Use of Follitropin Delta associated with Menotropin to induce ovulation in high-risk patients for Poor Response in In Vitro Fertilization	Not yet recruiting	Intervention	2020-02-10	<NULL>	<NULL>	3470	Follitropin Delta plus Menotropin for Ovarian Stimulation during In Vitro Fertilization treatments in patients at risk of ovarian poor response: a prospective clinical trial	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-03-01	Clinica Vidabemvinda	Clinica Vidabemvinda	https://ensaiosclinicos.gov.br/rg/RBR-2kmyfm	<NULL>	"Informed consent signed before starting the treatment cycle; Good physical and mental health; Pre-menopausal women aged at least 18 and at most 40 years of age when they sign the consent form and when they start the treatment cycle, in that order; Infertile women diagnosed with tubal, unexplained infertility, endometriosis stage I or II or whose partners have a male factor and are eligible for IVF or intracytoplasmic sperm injection (ICSI) using fresh or frozen semen from the partner or donated; Infertility of at least one year before the start of the study for women up to 37 years old and for at least 6 months for women aged 38 years or more (not applicable if there is already known tubal or male factor);
The cycle included should be the individual&apos;s first controlled ovarian stimulation cycle for IVF;Regular menstrual cycles lasting between 24 and 35 days, presumably ovulatory; Hysterosalpingography, hysteroscopy, hysterosonography or transvaginal ultrasound documenting uterus with anatomy compatible with pregnancy (that is, without evidence of submucosal or intramural uterine fibroids larger than three centimeters, polyps or congenital anomalies that are associated with reduced chances of pregnancy within one year before the start of the study);Transvaginal ultrasound documenting the presence of both ovaries in an accessible position for egg collection, without clear evidence of other normalities (that is, endometriomas larger than three centimeters or ovaries of very large volume that contraindicate the use of gonadotropins) and normal attachments (that is, without hydrosalpinx) within one year before the start of the study; Serum FSH levels in early follicular false (from the second to the fourth day of the cycle) between 1 IU per L and 15 IU per L, obtained within three months of the beginning of the study; Negative serologies for HIV, HTLV, Hepatitis B (surface antigen and anti-core), Hepatitis C and syphilis, within 6 months of the beginning of the study and Zika virus in the month of the beginning of the cycle; Body mass index between 17.5 and 32 kg per square meter (including both values) at the beginning of the study; Availability to accept a transfer of up to two blastocysts originating from the study cycle within one year after inclusion"	"known stage III or IV endometriosis;
One or more follicles greater than or equal to 10 mm on the day the stimulation starts; History of recurrent miscarriage (three consecutive losses before 24 weeks, excluding ectopic pregnancy); Abnormal karyotype of the woman or partner or semen donor. In cases where the seminal analysis shows a concentration below one million sperm per mL, a Y chromosome microdeletion test with normal results is mandatory; Any significant systemic clinical disease (eg, insulin-dependent diabetes); Any known hereditary or acquired thrombobophilia; Active arterial or venous thromboembollism or severe thrombophlebitis, or history of these events; known porphyria; Any endocrine-metabolic disease (pituitary, adrenal, liver, pancreas and kidney) that may compromise participation in the study, with the exception of well-controlled thyroid disease; Presence of known anti-FSH antibodies (based on history and previous tests and not on tests performed during that study); Known tumors of ovary, breast, uterus, adrenal, pituitary or hypothalamus that contraindicate the use of gonadotropins; Impaired kidney or liver function; Current lactant; Abnormal vaginal bleeding without a definite cause; Abnormal cervical oncotic cytology within three years of the start of the study (unless already treated and resolved); Findings of gynecological exams that reduce the chance of pregnancy (congenital uterine malformations and retained intrauterine devices); Current pregnancy (negative pregnancy test documented at the beginning of the cycle) or contraindication for pregnancy; Current pelvic inflammatory disease; Use of fertility modifiers at the beginning of the study such as DHEA, pills, progestogens or estrogens; Use of hormonal medications (except for thyroid); Known history of chemotherapy (except for gestational trophoblastic neoplasia) or radiation therapy; Current or past drug and alcohol abuse within one year of starting the study (drinking more than 14 units of alcohol per week); Current or past smoking within three months of the start of the study (more than 10 cigarettes per day); Hypersensitivity to any of the inputs used in the study; Have already participated in the study; Use of drugs not yet registered within three months of the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7z7f5s	Peanut Ball on Maternal Fatigue in Labor	Not yet recruiting	Intervention	2020-02-11	<NULL>	<NULL>	3474	Effectiveness of Peanut Ball Use on Maternal Fatigue During Labor	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Associação Vitoriense de Educação, Ciências Cultura	Associação Vitoriense de Educação, Ciências Cultura	https://ensaiosclinicos.gov.br/rg/RBR-7z7f5s	<NULL>	"Age over 18 years
Pregnant woman in the first period of labor
Low risk pregnancy
Gestational age between 37 and 42 weeks
Nulliparous, primiparous and multiparous
Single and cephalic pregnancy"	"Gestation with dead fetus
Parturient without ability to consent
Pregnant women with actual indication for cesarean section
Psychoactive drug use
Use of epidural or oxytocin analgesia before randomization"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-3kjd8x	Clinical trial comparing the utilization of Itraconazole and of Pentamidine for the treatment of Cutaneous Leishmaniasis in Amazonas	Not yet recruiting	Intervention	2020-02-11	<NULL>	<NULL>	3477	Itraconazole versus Pentamidine for the treatment of Tegumentary Leishmaniasis caused by Leishmania guyanensis in Amazonas - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-02-17	Fund. de Medicina Tropical Dr Heitor Vieira Dourado	Universidade do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3kjd8x	<NULL>	Patients with Ulcerated Cutaneous Leishmaniasis, not previously treated; diagnosed through at least one of the following tests: direct examinations of the lesion, biopsy of the lesion, culture or polimerase chain reactions (PCR) positives to Leishmania guyanensis; age of 18-65 years old; both genders; presenting at least 1 to 3 ulcerated lesions, in any localization; lesion diameter between 1-5 cm; clinical evolution not inferior to 1 month and not superior to 3 months.	Evidence of severe underlying disease (heart, kidney, liver, lung) or malignant disease; immunodeficient or HIV-infected patients; severe protein and / or caloric malnutrition; any active and uncontrolled infectious disease, such as tuberculosis, leprosy, systemic fungal disease (histoplasmosis, paracoccidioidomycosis); pregnant or nursing women; history of previous treatment for leishmaniasis; inability or willingness to provide informed consent (patient and / or / legal representative); lack of availability for visits or to comply with study procedures; patients participating in another ongoing clinical study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8yy2bg	Effect of street running on weight loss for people with Overweight and Obesity	Not yet recruiting	Intervention	2020-02-12	<NULL>	<NULL>	3480	Effect of a sports training level running program on the body composition of Overweight and Obesity adults	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8yy2bg	<NULL>	Men and women, aged between 20 and 45 years, with overweight / obese (BMI between 25kg / m² and 34.9kg / m2) (WHO, 2015), previously sedentary for at least three months prior to study enrollment (no physical exercise for at least 10 continuous minutes / week ), have not changed more than 3 kg of body mass in the last 3 months, non-smokers, non-users of supplements and medications that influence body mass, no history of cardiovascular, respiratory, metabolic or musculoskeletal disease affecting the ability to participate in training programs, women are not menopausal or are not in the period of climacteric, moreover, were considered fit in the physical evaluation done immediately before the study.	People who start drug treatment, supplementation or diet and / or start another physical exercise during the intervention period and if they have orthopedic conditions that affect their ability to continue participating in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-7s93fj	Relationship between general movements, trunk control, hand reach and fine motor function of premature babies	Not yet recruiting	Observational	2020-02-13	<NULL>	<NULL>	3488	Prediction between generalized movements and level of truk control, manual reach and fine motricity of pre-term infants	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-03-03	Kaitiana Martins da Silva	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7s93fj	<NULL>	The inclusion criteria for the EG (Experimental Group) will be: infants with corrected age between 1 to 5 months on the date of the evaluation, gestational age less than 37 weeks, in addition to signing the Informed Consent Form (ICF) by the parents or responsible. For the CG (Control Group), they will be born at term (gestational age at birth from 37 to 41 weeks and 6 days) and paired with the same age. For both groups, both genders will be considered, birth weight appropriate for gestational age and Apgar score between 7 and 10 in the first and fifth minutes	Infants who have congenital malformations, genetic syndromes, congenital changes, postural deformities or other changes that may impair the neuropsychomotor and socio-cognitive development will not participate in the study. In addition to those that parents / guardians do not sign the ICF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-7djt4p	Searching susceptibility to hepatitis A among men who have sex with men in Rio de Janeiro	Not yet recruiting	Intervention	2018-10-05	<NULL>	<NULL>	3499	A cross-sectional study to determine susceptibility to hepatitis A among men who have sex with men in Rio de Janeiro (HEPAGAY)	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-27	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-7djt4p	<NULL>	Men aged 18 to 35 years old male at birth who report having had sexual relations with people of the same biological sex in the last six months and live in Rio de Janeiro metropolitan area.	Subjects who have received at least one shot of hepatitis A vaccine at some point in their life. Subjects who live with any autoimmune disease. Any other condition which based on the opinion of the investigator  may compromises adherence to the protocol or otherwise interferes with the objectives of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-639bff	Comparison of the effectiveness of sweetened solution and foot massage in relieving pain in infants admitted to a neonatal intensive care unit	Not yet recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3504	"Comparison of eficacy of glucose and
reflexotherapy in newborn pain relief in Neonatal Intensive
Therapy Unit: A clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-27	Daniele Vieira Dantas	Daniele Vieira Dantas	https://ensaiosclinicos.gov.br/rg/RBR-639bff	<NULL>	The inclusion criteria of the research are Newborns equal to or greater than 32 weeks of gestation or weighing 1500g or more undergoing exam collection 12-hour laboratory tests / blood gas analysis / blood culture through arterial puncture.	Neonates diagnosed with perinatal asphyxia (Apgar score less than 5 in 5 minutes); which do not show reflex who are using analgesics or sedatives; with malformations congenital disorders, syndromes and neurological manifestations; the son of women drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-5435x9	Brain electrical stimulation associated with speech therapy in speech apraxia in young people with Trisomy 21 (Down Syndrome)	Not yet recruiting	Intervention	2020-02-19	<NULL>	<NULL>	3509	Transcranial Direct Current Stimulation associated (tDCS) with Prompts for Restructuring Oral Muscle Phonetic Targets (PROMPT) in Apraxia of Speech in young people with Trisomy 21	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Federal do Espírito Santo	Ester Miyuki Nakamura Palacios	https://ensaiosclinicos.gov.br/rg/RBR-5435x9	<NULL>	They have to present clinical and / or genetic diagnosis of Trisomy 21 and meet criteria for intellectual disability (DSM-5) or intellectual development disorder (equivalent name found in ICD 11), and are classified according to the severity as mild (F70), moderate (F71), severe (F72), and profound (F73) according to ICD 10; they have to meet criteria for communication disorders (DSM-5), specifically speech sound disorder (F80.0); they should be clinically fit for the treatment proposed in the study and should therefore not present past or current illnesses that may be aggravated during treatment; they should also not have abnormalities in the laboratory tests, which may suggest a deterioration of their physical condition during the participation in the study; they should be able to understand the Portuguese language.	"It should not be included young people diagnosed with other associated mental disorders such as attention deficit hyperactivity disorder (ADHD), depressive and bipolar disorders, anxiety disorders, autistic spectrum disorder, stereotypic movement (with or without self-injurious behavior), impulsive disorders, and major neurocognitive disorders;
those who have any metal in their brain or skull (splinters, fragments, pins, etc.) except for titanium, history of epilepsy, severe head injury, cochlear implant, cardiac pacemaker or intracardiac metal lines, should also not be included because of restrictions on the noninvasive brain stimulation technique; they will not be included due to MRI restrictions if they are carrying metal implant such as: heart valve, plate, pin, screw, stent, brain aneurysm clip, body shrapnel, piercing, metal prosthesis, orthodontic appliance, electronic implants such as cardiac pacemakers, neurostimulators, cochlear implants, claustrophobic patients and those with permanent makeup or tattooing done in the last three months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:32
RBR-9gj9mn	The effect of combining high-intensity interval training with nitrate supplementation in trained people	Not yet recruiting	Intervention	2020-02-20	<NULL>	<NULL>	3513	Acute and chronic effects of High Intensity Interval Training associated with Sodium Nitrate Supplementation on Aerobic Parameters and Performance of Physically Active Subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9gj9mn	<NULL>	Male individuals, aged between 18 and 35 years old, without distinction of education levels or other sociodemographic characteristics will be selected; with absence of cardiovascular, metabolic, respiratory, orthopedic diseases and neurological, muscular, cognitive deficit that make it impossible to understand the evaluation or verbal commands.	Individuals who present intolerance or allergy after supplementation will be excluded; Failure to follow directions given in advance of each experimental session; refuses to take supplementation; have difficulty adapting to the protocol; have more than six absences during the intervention period (corresponding to 25% of the total number of sessions in the 8 weeks of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-8xcjmf	Prenatal group&apos;experiences	Not yet recruiting	Intervention	2020-02-26	<NULL>	<NULL>	3528	Prenatal group implementation at the center for integral health care of women at the state university of Campinas: a pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-11	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8xcjmf	<NULL>	"Pregnant women 18 years of age and over;
Pregnant women with gestational age (GA) less than 20 weeks of gestation;
Pregnant women in prenatal care at PNE on Wednesday of CAISM / UNICAMP;
Signing of the Informed Consent (IC)"	"Professional indication validated by PNE teacher to individualize care (will be sent to the indicated professionals or sectors, eg hospitalization, other outpatient clinic, etc.);
ICF Withdrawal"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-98dxv3	Methods of controlling symptoms of temporomandibular dysfunction and bruxism	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3533	Effectives of different methods os interventions in TMD symptoms and Brussels - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Juliane Dias de Oliveira	Juliane Dias de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-98dxv3	<NULL>	Women will be included in the sample; older than 18 years; TMD symptomatology; bruxism reported and possessing smartphone.	Use of painkillers; antiinflammatories; botulinum toxin; myorelaxant plate for TMD treatment; in orthodontic treatment; who only have a diagnosis of bruxism or TMD.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3csfjq	Efficacy of non-surgical treatment in patients with inflammation around teeth and implants without bone loss.	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3535	Efficacy of Non-surgical Treatment in patients with Gingivitis and Peri-implant Mucositis.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-06	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3csfjq	<NULL>	Present clinical diagnosis of mucositis peri implant, i.e., present probing depth of up to 5 mm, bleeding to the probing without evidence of radiographic bone loss in addition to the first two threads of implants; Be rehabilitated with unitary prosthesis, protocol or overdenture; Be partially or totally toothless; individuals who have been rehabilitated for at least 1 year. For cases of gingivitis, present clinical diagnosis of gingivitis in intact periodont, i.e., present probing depth less than or equal to 3 mm, 10% or more of sites with bleeding to the probing, absence of loss of insertion and bone loss Radiographic Patients presenting sites with probing depth of up to 3 mm, 10% or more of sites with bleeding to the probing, loss of insertion and possible radiographic bone loss; Patients with a history of treatment of periodontitis, therefore, presenting loss of insertion, sites with periodontal pouch of up to 3 mm, 10% or more of sites with bleeding to the probing and radiographic bone loss.	o present systemic complications, such as cardiovascular diseases, Alzheimer&apos;s, lung diseases, cerebral or metabolic syndromes;Have used antibiotics, anti-inflammatories, immunosuppressants or periodontal treatment in the last 6 months prior to the survey;Individuals who are in the gestational or breastfeeding period;Individuals who use orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:33
RBR-3h6nkn	Effect of Speech Therapy on snoring in obese patients	Not yet recruiting	Intervention	2020-02-28	<NULL>	<NULL>	3539	Effect of Orofacial Myofunctional Therapy on the room of obese patients: ramdomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Universidade Estadual do Oeste do Paraná - Campus Cascavel	Universidade Estadual do Oeste do Paraná - Campus Cascavel	https://ensaiosclinicos.gov.br/rg/RBR-3h6nkn	<NULL>	Minimum age of 18 years; have a smartphone; accept sleeping in a room separate from the partner; agree to participate in the research by signing the Free and Informed Consent Form.	Non-availability to do the treatment for the established period; benzodiazepine medication users; continuous users of muscle relaxants; alcoholics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-8cy8xb	Effect of consumption of beneficial bacteria associated with diet on body fat, intestinal health and aspects related to the immune system of obese people	Not yet recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3545	Effect of probiotic supplementation associated with dietary intervention on body composition, intestinal microbiota and inflammatory biomarkers in adult individuals obese young people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Camila Guazzelli Marques	Departamento de Psicobiologia da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cy8xb	<NULL>	Male volunteers; sedentary; age between 20 to 40 years; body mass index (BMI) between 30.0 and 34.99kg / m2, which is obtained by dividing body weight, measured in kilograms, by the square height, measured in meters (kg / m2)	diabetics; vegetarians and vegans; accompanying with a nutritionist; performing any diet or food restriction; gastrointestinal surgery; using antibiotics in the last six months and anti-inflammatory drugs in the last fifteen days and the evaluation weeks; use of weight loss medications and/or antidepressants; use of drugs from the serotonin receptor family; regular consumption of probiotic/fermented products (kefir and kombucha); use of nutritional supplements (probiotics, prebiotics, symbiotics, multivitamins, omega-3, Whey Protein, and creatine); smokers; consumption of alcoholic beverages (&gt; 30.0 grams of alcohol per week); regular physical exercise at least twice a week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-96dpjz	Association between pain, mastication and inflammation during treatment with different orthodontic appliances	Not yet recruiting	Intervention	2020-03-02	<NULL>	<NULL>	3546	Association between pain, mastigatory quality and inflammatory cytoxins in self-related appliances and aesthetic aligners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Aline Medeiros	Aline Medeiros	https://ensaiosclinicos.gov.br/rg/RBR-96dpjz	<NULL>	age range from 12 to 35 years old; need for orthodontic treatment; with dental crowding between 4 and 8 mm in the upper arch; with proper oral hygiene; no caries; both sexes.	symptoms of temporomandibular joint dysfunction; chronic use of anti-inflammatory drugs or antibiotics; with periodontal disease with generalized probing depth of 3 mm at the test sites; with craniofacial anomalies; wearing orthodontic devices that cause discomfort.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-487ctp	Comparison of two treatment options for patients with precursor lesions of skin cancer: colchicine cream versus 5-FU cream	Not yet recruiting	Intervention	2020-03-03	<NULL>	<NULL>	3555	Clinical and dermatoscopic evaluation of the effectiveness of Colchicine 0,5% cream versus 5-Fluorouracil 5% cream in the treatment of Actinic Keratosis and Cutaneous Cancerization Field: a randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-03-17	Instituto Lauro de Souza Lima (ILSL)	Faculdade de Medicina da Universidade Estadual Paulista (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-487ctp	<NULL>	Sign the Informed Consent Form; age over 18 years, both sexes; present a minimum of 3 and a maximum of 10 lesions clinically compatible with AK on each dorsal face of the forearm.	Exclusion criteria: treatment area that has an atypical clinical appearance, suggestive of carcinoma, or other extensive dermatoses; current and / or previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances under study; patients using any systemic or topical immunosuppressive substance, oral retinoid, in addition to other local treatments (eg: corticosteroids, anti-inflammatories, topical retinoids); patients who have received any type of treatment for skin field cancerization less than 6 months before the start of the study; immunocompromised individuals; coagulation disorders; suspected or confirmed pregnancy; women of childbearing potential who do not use contraception; women who are breastfeeding. Discontinuation criteria: withdrawal of consent; presence of infection (erysipelas, cellulitis or abscess) during follow-up in the treatment areas; loss of follow-up; use of other AK treatment methods other than the one proposed; serious adverse event, at the investigator&apos;s discretion; pregnancy during follow-up; failure to take photographic images of the lesions on the days determined before the start of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-9wfww5	Radiofrequency within the vagina in the treatment of involuntary urine loss: Randomized clinical trial	Not yet recruiting	Intervention	2020-03-04	<NULL>	<NULL>	3558	Transvaginal radio frequency in the treatment of urinary incontinence: Randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Programa de Pós-Graduação em Gerontologia Biomédica da Pontifícia Universidade Católica do Rio Grande do Sul	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9wfww5	<NULL>	Women from the PUC gynecology outpatient clinic who are post menopausal, with a diagnosis of stress urinary incontinence or mixed stress urinary incontinence will be included, who have no urinary infection on urine examination and want to participate in the study.	Desire for surgical treatment for urinary incontinence, pelvic tumors, pelvic prolapses grade III and IV, previous surgery for urinary incontinence or genital prolapse, neurogenic bladder, patients with cardiac pacemakers and undergoing parallel physiotherapeutic treatment for urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:34
RBR-7ffw9k	Guidance and Physiotherapy in the treatment of patients with Acute Low Back Pain	Not yet recruiting	Intervention	2020-03-05	<NULL>	<NULL>	3562	Minimal Intervention vs. Physical Therapy in the treatment of patients with Nonspecific Acute Low Back Pain: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federeal de São Paulo - UNIFESP	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7ffw9k	<NULL>	Patients diagnosed with acute nonspecific low back pain; both genders; age between 18 and 60 years; who agree to participate in the research and sign the IC.	Patients with a history of previous spine surgery; who have undergone physical treatment for low back pain in the past six months; who present clinical warning signs for the presence of fractures, tumors or infections and for the presence of inflammatory, pelvic and abdominal diseases; patients with the presence of associated neurological symptoms indicative of radiculopathy; patients who have contraindications to the use of anti-inflammatory drugs; pregnant women; illiterate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-55bc85	Lactobacilli associated with antibiotics in the treatment of periodontitis in smokers	Not yet recruiting	Intervention	2020-03-06	<NULL>	<NULL>	3568	Antibiotic associated with probiotic in the treatment of chronic periodontitis in smokers	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-05-01	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-55bc85	<NULL>	Patients aged between 30 and 70 years old; diagnosis of severe generalized chronic periodontitis; heavy smokers (more than 10 cigarettes per day for more than 5 years) and at least 15 teeth in mouth, excluding third molars.	Medical disorders that require antibiotic prophylaxis or who could influence the response of the treatment; having received treatment for periodontal scaling and root planing in the last 6 months; having consumed drugs that affect the periodontal tissues in the last 6 months (antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants or calcium channel blockers); pregnancy; prosthetic rehabilitations extensive carrier; in orthodontic treatment; patients with metabolic disorders such as diabetes; immune disorders; alcohol and illicit drug use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-6hwx3k	Self-monitoring for women&apos;s empowerment to reduce the risks of high blood pressure during life, after a pregnancy with specific high blood pressure	Not yet recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3579	Self-monitoring to empower women to reduce the risk of hypertension later in Life After a Pregnancy with Preeclampsia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-14	Unesp - universidade estadual paulista	Fapesp - fundação de amparo a pesquisa do estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6hwx3k	<NULL>	Postpartum patient; age 18 or over; diagnosis of preterm preeclampsia in pregnancy and smartphone and internet access;	Multiple pregnancy; presence of comorbidities, including kidney disease, active liver disease (hepatitis), heart disease, diabetes mellitus and other comorbidities requiring individualized follow-up and women who start a new pregnancy during the study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-88cjpb	Automated screening to assess and manage the use of alcohol, tobacco and other substances	Not yet recruiting	Intervention	2020-03-09	<NULL>	<NULL>	3581	Feasibility and acceptability of implementing an automated self-screening to assess and manage the use of alcohol, tobacco and other substances	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Raquel Brandini De Boni	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-88cjpb	<NULL>	HIV-positive individuals; with 18 years or more; under care at INI-FIOCRUZ; who are included in the HIV-INI cohort	NA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:35
RBR-2d56bt	Effects of Functional Training on the immune system and inflammatory responses, body composition and functionality in Overweight elderly women	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3590	Effects of Functional Training on immunological and inflammatory parameters, body composition and functionality in Overweight elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-30	José Carlos Aragão Santos	José Carlos Aragão Santos	https://ensaiosclinicos.gov.br/rg/RBR-2d56bt	<NULL>	Being female. At least 60 years of age. Be physically independent. Have a body mass index greater than 24.9 kg / m². Obtain a minimum score of 14 on the mini mental state exam (FOLSTEIN et al., 1975). Absence of musculoskeletal or cardiovascular disorders that make it impossible to perform high-intensity physical exercises. Be at least six months without performing any regular physical activity.	Attendance rate below 80%. Miss any of the evaluation sessions. Begin some type of regular exercise practice in addition to that proposed in this work during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-4hqvqr	The effect of two types of restorations on deciduous teeth in babies	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3592	Effectiveness of restorations in resin-modified glass ionomer cement and bulk-fill resin in deciduous molars of babies: randomized clinical trial protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4hqvqr	<NULL>	Children physically classified according to the American Society of Anesthesiology (ASA) at level I (healthy); who are undergoing treatment or waiting list for care in pediatric dentistry clinics from FAO-UFMG; Between 18 up to 36 months of age; who present at least two cavitated caries lesions restricted to the occlusal face in radiographically detectable primary molars in dentin, characterized as medium and deep lesions (SCHWENDICKE et al., 2016) being one lesion in each left and right); Only children whose parents/guardians sign the consent form.	Children with deep caries lesions affecting the pulp chamber or at risk of exposure; who have fistula or abscess; pulp exposure; history of spontaneous pain or tooth mobility associated with decayed teeth; molar teeth with other restorations, enamel defects, or endodontic treatment that have carious lesions associated with an existing restoration or that do not stabilize the clamp for absolute isolation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-226f6j	Clinical and microbiological evaluation after treatment at the site of chronic periodontal disease, with gels containing antimicrobial agents	Not yet recruiting	Intervention	2020-03-10	<NULL>	<NULL>	3599	Clinical outcomes and microbiological evaluation after in situ treatment of chronic periodontal disease, using antimicrobial-loaded polymeric bioadhesive systems	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-05-15	Faculdade De Odontologia de Ribeirão Preto	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-226f6j	<NULL>	Patients with chronic periodontitis, with clinical insertion level equal to or greater than 6mm in two or more teeth and probing depth equal to or greater than 5mm in one or more periodontal sites (MACHTEI et al., 1992); Age range from 30 to 75 years old; Not having used antibiotics for at least 3 months; No history of allergy to the components present in the formulations to be tested (MDZ and Tetracyclines).	Severe cardiovascular disease; Pharmacokinetic problems such as nephropathy, liver disease, etc. Patients with a history of tetracycline allergy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-8dtkq9	Effects of Grape Seed Flour consumption on intestinal flora and metabolic parameters of  individuals with Obesity	Not yet recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3603	Effects of Grape Seed Flour intake on intestinal microbiota and metabolic parameters in  individuals with Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Luciana Pellegrini Pisani	Yasmin Alaby Martins Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-8dtkq9	<NULL>	Male and female adults; between 20 and 59 years old; residents from Baixada Santista; with obesity, BMI between 30 and 39.9 kg/m²	Regular or continuous use of anti-inflammatory or antibiotic medications in the last 3 months; chronic alcohol intake above 30grams per day; heart disease; liver disease; kidney disease; cancer; acute gastrointestinal problems, including diagnosed lactose intolerance; pregnancy or lactation; and menopause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-8kgqk4	Effect of a muscle strengthening of the 1st dorsal interosseous in subjects with rhizarthrosis: a randomized controlled trial.	Not yet recruiting	Intervention	2020-03-11	<NULL>	<NULL>	3605	Effect of a treatment protocol focusing on Muscle Strengthening of the 1st dorsal interosseous on aspects of activity and participation in subjects with Rhizarthrosis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8kgqk4	<NULL>	Volunteers with a medical diagnosis of rhizarthrosis; without cognitive impairment, taking into account a normal score on the Mini-Mental State Examination for the respective level of education.	Uncontrolled diabetes; neurological and/or musculoskeletal disorders that may affect upper limb function; fracture or previous surgical intervention on the wrist or fingers; the presence of any other rheumatologic disease; TMC joint infiltration within the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-76qyq8	Postoperative follow-up of 5 years of surgical treatment for urinary loss of effort	Not yet recruiting	Observational	2020-03-11	<NULL>	<NULL>	3610	Clinical study between Mini-slings and Transobturator sling for the treatment of Stress urinary incontinence: a 5 year follow up	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Centro Universitário Saúde ABC - FMABC	Centro Universitário Saúde ABC - FMABC	https://ensaiosclinicos.gov.br/rg/RBR-76qyq8	<NULL>	Patients over the age of 18 years; absence of associated neurological diseases; patients previously submitted to surgical treatment to correct urinary incontinence, either by transobturing sling or mini-sling; patients who accept to attend and undergo the proposed procedures.	Pregnancy; acute urinary infection; sequelae of high exposure to ionizing radiation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:36
RBR-5539cm	Randomized trial using amitriptyline medication to prevent neuropathic pain in patients who have leprosy neuritis.	Not yet recruiting	Intervention	2020-03-16	<NULL>	<NULL>	3619	Randomized clinical trial of the use of amitriptyline for the prevention of neuropathic pain in patients with leprosy neuritis	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2020-03-30	Fundação Oswaldo Cruz	Instituto Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-5539cm	<NULL>	The study will include patients older than 18 years; with a clinical diagnosis of neuritis; confirmed by electroneuromyography; registered at the service and diagnosed with neuritis; from February 2020 to January 2022.	Patients diagnosed with neuropathic pain;Patients with known contraindications to the use of amitriptyline: ischemic heart,disease, cardiac arrhythmia, glaucoma and / or history of urinary retention in men;Patients with concomitant leprous nodular; erythema being treated with thalidomide;Patient with previous use ofamitriptyline and  or neuropathic pain;Patient with cognitive impairment;Pregnancy or breastfeeding;Prophylactic use of amitriptyline in a previous episode of neuritis, that is, the patient will only be included once	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-3g6q92	Use of copaiba oil-based emulsion in the teeth restoration process	Not yet recruiting	Intervention	2020-03-18	<NULL>	<NULL>	3625	Clinical Trial of Copaifera multijulga Hayne oil-based Emulsion as a biomodifier of dentin adhesion	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3g6q92	<NULL>	The participant must present deciduous molar teeth with up to 1/3 of root resorption affected by a shallow or medium occlusive-proximal caries lesion with surrounding enamel throughout; do not present dental malformation and spontaneous pain in the teeth. Do not have systemic disease, such as diabetes, hypertension and heart disease.	Patients will be excluded if there is a fistula or edema in the intra or extra-oral region, radiolucency in the furcation region of the tooth, or if the successor tooth of the deciduous tooth is missing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-45kmbp	Effects Of Continuous Current In Shadows And Quality Of Life In Women With Primary Hyperidrosis	Not yet recruiting	Intervention	2020-03-19	<NULL>	<NULL>	3634	Direct current aApplication in the treatment of hyperhidrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-45kmbp	<NULL>	Female volunteers, aged 18 to 300years old, who had primary hyperhidrosis without ever having received previous treatment for this chronic disease (treatment).	Male patients, patients with sensitivity to electric current, patients with dermatological damage, heart problems, pregnant women, diabetics or those with uncontrolled hypertension, as well as those with neoplasms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:37
RBR-7g4gp4	Effect, safety and action of Ketotifen associated with Famotidine  in the treatment of facial stains.	Not yet recruiting	Intervention	2020-03-20	<NULL>	<NULL>	3637	Evaluation of the efficacy of using Ketotifen associated with Famotidine in the oral treatment of facial melasma in women: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-20	Faculdade de Medicina de Botucatu (FMB - Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-7g4gp4	<NULL>	women; aged 18 to 60 years; moderate to severe facial melasma; no treatment for at least 30 days.	dermatoses with photosensitivity; history of hypersensitivity to ketotifen or famotidine; personal history of liver disease; pregnant women; lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-5w6gk2	Cardiovascular physiotherapy in the health care unit	Not yet recruiting	Intervention	2020-03-23	<NULL>	<NULL>	3646	Cardiovascular physiotherapy in primary care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Estadual de Goiás	Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5w6gk2	<NULL>	Will be included in the study of sedentary patients of both sexes; without cognitive impairment (mini-mental more than 17);  aged 60 years or over; independent walking and CSF Jardim Dom Fernando II frequenters.	Elderly practitioners of regular physical activity (more than 150 minutes of moderate-intensity physical activity per week), with unstable angina, cardiac resynchronizer, cardiac surgery less than three months, heart failure (NYHA class III,IV), will be excluded. diabetes mellitus (fasting glucose more than 180 mg.dL and or glycated hemoglobin more than 7.0%), chronic renal failure (glomerular filtration less than 50 ml.min.1.73m2), with impaired cognitive impairment, need walking aids for locomotion or any clinical condition that prevents physical activity and the impossibility of attending the physiotherapy sector twice a week during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-3mm7cs	Metagenomic analysis of the colony of bacteria from the intestine of premature babies undergoing treatment with Colostrotherapy treated by the Unified Health System (SUS): Intervention Study	Not yet recruiting	Intervention	2020-03-25	<NULL>	<NULL>	3655	Metagenomic Analysis of the Intestinal Microbiota of premature infants undergoing treatment with Colostrotherapy treated by the Unified Health System (SUS): Intervention Study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-10	Jessica Santos Passos Costa	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-3mm7cs	<NULL>	"The inclusion criteria for the control group (from HEC) will be: premature newborns
admitted to Neonatal Units, birth weight 1,500g, 32 weeks gestational age, They must be on a zero diet orally and enteral or using total parenteral nutrition (NTP), and / or enteral administration of infant formula and clinically stable, with normal parameters. In addition, to collect the fecal sample, the newborn will be included if the first evacuation was made at the NICU. The mothers of infants, both for the group of intervention, as well as for the control group, will be selected according to the eligibility criteria of your children&apos;s entry into the study"	"Among the exclusion criteria: mother&apos;s, maternal history of substance use psychoactive drugs, drugs, alcohol, presence of 
 psychological disorder, multiple pregnancy from triplets and children of mothers contraindicated for breastfeeding retroviruses and cytomegalovirus). RN: use of vasopressor medication bigger then 10mcg / Kg / min, requirement for immediate surgical intervention, syndromes and / or congenital malformations, neonatal morbidities such as the incidence of patent ductus arteriosus (PDA), sepsis or necrotizing enterocolitis (NEC), The newborn who eliminates meconium in the Obstetric Center (CO)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:38
RBR-6vfwnx	Effects of respiratory muscle training on functional capacity in neurological patients	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3664	Effect of respiratory muscle training on functional capacity in individuals with Parkinson&apos;s disease or post stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-30	Universidade Federal da Bahia	Cnetro Universitário Social da Bahia UNISBA	https://ensaiosclinicos.gov.br/rg/RBR-6vfwnx	<NULL>	Age greater than 18 years; confirmed medical diagnosis of Parkinson&apos;s disease with a degree of severity between 1 and 3 according to the HOEHN &amp; YAHR classification or stroke diagnosed six months ago; ability to understand and perform respiratory maneuvers with appropriate technique; absence of pulmonary or neuromuscular disease; except Parkinson&apos;s disease.	Will not be included in the study, individuals who present cognitive alterations according to the Mini Mental State Examination, observing the following score; if illiterate; score less than 19 points; with 1 to 3 years of schooling; score below 23 points; with 4 to 7 years of schooling; score below 24 points, and above 7 years of schooling; score less than 28 points. They present osteomioarticular lesions that make physical activity impossible; chronic uncontrolled diseases such as hypertension; diabetes mellitus and chronic pain. Unstable cardiovascular diseases such as acute heart failure; recent myocardial infarction; unstable angina and uncontrolled arrhythmias. Lung or other diseases that adversely affect the respiratory pump, including asthma and chronic obstructive pulmonary disease. Use of alcohol and other toxic substances; have facial paralysis or difficulty in sealing the mouthpiece during training. In addition to the aforementioned criteria; participants will be excluded in cases of absences exceeding three at the end of eight weeks of treatment; present osteomioarticular or cardiovascular changes acquired during the treatment period that make physical activity and / or inspiratory muscle training impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-23p4zr	The use of lasers with antimicrobial drugs to treat infected wounds in people with diabetes: randomized clinical trial	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3665	Laserterapy associated with photodynamic therapy in the treatment of infected wounds in persons with diabetes: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Maria Girlane Sousa Albuquerque Brandão	Universidade Internacional da Integração da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-23p4zr	<NULL>	Individuals aged 18 years or over; being diabetic and presenting an infected wound (evaluation of the wound will be carried out by analyzing clinical signs: presence of odor, exudate, discoloration of the tissues inside and margins of the wound, edema, friable and hemorrhagic granulation tissue); attend the clinic on pre-established days.	Suspected or confirmed pregnancy; use immunosuppressive drugs; being on antibiotics or having finished treatment less than 30 days; use of any topical medication on the wound for less than seven days; diagnosis / Treatment of Carcinoma; presenting a wound with an area greater than 144 cm2; anemia (Hb less than 12 g / dL); Chronic Kidney Failure; osteomyelitis; being under the influence of alcohol or psychotropic substances; chronic malnutrition; peripheral vascular insufficiency.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-48yfcc	Comparison of the Acute Effect of different types of motor and mental stimuli and combined under the mental, autonomic and motor function of the patient with Respiratory Disease a randomized clinical trial	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3666	Comparison of the Acute Effect of different types of physical and cognitive and combined stimuli under the cognitive, autonomic and motor function of the patient with Chronic Obstructive Pulmonary Disease a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-48yfcc	<NULL>	Medical clearance for testing; diagnosis of COPD; being older than 55 years; without exacerbation or infections for less than 4 weeks; without performing physical activity for at least 4 weeks	Dizziness; Chest pain; severe dyspnoea; SBP greater than 220mmHg and DBP greater than 120mmHg; SpO2 less than 90%; Difficulty adapting to virtual reality; Difficulty using the cycle ergometer; interruption of intervention on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-92d653	Molding techniques and their impact on retention in removable dentures	Not yet recruiting	Intervention	2020-03-26	<NULL>	<NULL>	3669	Functional impression techniques in conventional full dentures: Impact on retention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-19	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-92d653	<NULL>	Totally toothless bimaxillary patients who seek total dental prosthesis service at the Faculty of Dentistry of Pernambuco (FOP / UPE) seeking their rehabilitation; Participants who agree to participate in this research by signing the Free and Informed Consent Term (ICF); Participants over 18 years old; Completely edentulous participants for at least 1 year.	Patient with retentive rim; Patients with neoplastic and non-neoplastic proliferative processes in the oral mucosa; Patients with changes in the oral mucosa resulting from microbial infections; Patients with neuromuscular disorders; Xerostomia; Kelly syndrome patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-9rwqr3	Clinical study on gingival inflammation in teeth restored with ceramic veneers with and without finish line. Evaluation by clinical parameters and by bacteria and inflammatory mediators present in the gingival crevicular fluid.	Not yet recruiting	Intervention	2020-03-27	<NULL>	<NULL>	3672	Influence of ceramic veneers cemented over teeth with and without finish line on the inflammatory mediators and microbiota of gingival crevicular fluid. Clinical, controlled, randomized, blind, prospective and longitudinal study using ELISA and RT-PCR	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Odontologia de Araçatuba da Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-9rwqr3	<NULL>	Patients who require ceramic veneers restorations in the region between teeth 15 to 25; healthy teeth and in good periodontal health; the need to close diastemas; eliminate dead spaces; correct shape and dental contour with aesthetic and / or functional justification attested by diagnostic waxing.	Periodontal disease active; loss of insertion; probing depth greater than 3 mm; bleeding on probing in more than 10% of the evaluated sites; radiographic bone loss; pregnancy, diabetes mellitus; autoimmune diseases and other uncontrolled systemic changes with a detrimental effect on periodontal tissues; users of controlled drugs; presence of hormonal or vitamin deficiency; history of recent use (less than 3 months) of anti-inflammatories or antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-222dr8	Study in children with Obstructive Sleep Apnea, after surgery, treated with a dental appliance or speech therapy	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3681	Polysomnographic study in children with residual Obstructive Sleep Apnea Syndrome treated with Rapid Maxillary Expansion and / or Myofunctional Therapy or Orthopedic Mandibular Advancement	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Ciência Médicas - Unicamp	Universidade de Roma La Sapienza	https://ensaiosclinicos.gov.br/rg/RBR-222dr8	<NULL>	Children of both genders from 5 to 11 years old; with residual obstructive sleep apnea after adenotonselectomy	malformations; syndromes with craniofacial involvement; children undergoing orthodontic, orthopedic and myofunctional therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-7zyqq8	Comparison of the Acute Effect of different types of motor and mental stimuli and combined under the mental, autonomic and motor function of the patient with Respiratory Disease a randomized clinical trial	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3682	Effect of the lower limbs cycle ergometer associated with conventional physiotherapy in preserving the mobility, morphology and muscle strength of neurocritical patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7zyqq8	<NULL>	"diagnosis of acute neurological injury; aged between 18 and 65 years; use of invasive mechanical ventilation (IMV); 
with more than 24 hours of acute brain event or neurosurgery; admitted to the ICU"	diagnosis of Deep Venous Thrombosis (DVT); diagnosis of brain death (BD); no motor response to the stimulus of the electrostimulator; present criteria for interrupting or not performing the cycle ergometer more than 2 consecutive times or more than 5 times during the ICU stay; express request from a patient or family member to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-2yjtsn	Effect of a Health Education Program on the knowledge and training of pelvis muscles in women in the treatment of urinary loss	Not yet recruiting	Intervention	2020-03-30	<NULL>	<NULL>	3684	Effect of a Health Education Program on the knowledge and training of pelvic floor muscle in women in the treatment of Urinary Incontinence of Effort: a randomized study	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2019-08-12	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2yjtsn	<NULL>	The study will include women with complaints of urinary loss; over 18 years; who have never received training for MAP; who can read and write and understand the Portuguese language	Those who report or present any psychiatric disorder; cognitive deficit; neurological or incapacitating disease; who are pregnant, last child less than a year and previous surgery to correct UI; will be excluded; regardless of the time that was performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:39
RBR-6zvmxt	Evaluation of the muscular, neurophysiological and biomechanical structure of the lower limbs of patients with injuries of definition of Neuromuscular electrical stimulation during bicycle intervention- a randomized clinical trial	Not yet recruiting	Intervention	2020-04-03	<NULL>	<NULL>	3705	Morphological and neuromechanical evaluation of the lower limbs of Critical patients to define parameters of Neuromuscular Electrostimulation during intervention with a Cycloergometer- a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-06	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-6zvmxt	<NULL>	24 hours of invasive mechanical ventilation; being over 18 years old; present stable clinical conditions	pneumothorax, deep venous thrombosis and pulmonary thromboembolism, noradrenaline prescription, oxygenation index less than 150, recent history of deep venous thrombosis without use of anticoagulants, thrombocytopenia, hemodialysis patients, anasarca, prolonged weaning with failure in at least 3 tests spontaneous ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-8dmynv	Effect of an educational video on the promotion of self-care with arteriovenous fistula	Not yet recruiting	Intervention	2020-04-06	<NULL>	<NULL>	3706	Promotion of self-care with the arteriovenous fidtulaa through an educational video: randomized clinical test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8dmynv	<NULL>	Patients with arteriovenous fistula for at least six months; both sexes; age over 18 years.	mental or cognitive disorder that makes it impossible to apply the data collection instrument.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:40
RBR-5dxg2k	Wear control caused by diet or illness in patients with reflux- clinical study	Not yet recruiting	Intervention	2020-04-07	<NULL>	<NULL>	3713	Control of erosive tooth wear in patients with gastroesophageal reflux disease - a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-31	Hospital de Clínicas de Porto Alegre	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5dxg2k	<NULL>	Individuals aged &gt;= 18 years; both sexes; diagnosis of positive gatroesophageal reflux disease; at least one tooth with erosive tooth wear	Individuals with special needs; &lt;18 years; with difficulties in understanding the protocol and its guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-23j2m8	Dermatological evaluation of  GINOCONFORT	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3716	Dermatological evaluation of the photoirritating and photosensitizing potential_27567	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2020-08-01	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-23j2m8	<NULL>	Male and female participants; Age group between 18 and 70 years; Be in agreement not to change your habits of using health products, including hygiene; Skin intact in the test region; Agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for reading the dressings; Understanding, agreement and signing the Informed Consent Form (ICF).	Pregnancy or risk of pregnancy and / or lactation; (when women); Atopic or allergic background to health products; Use of anti-inflammatory drugs 30 days and / or immunosuppressive for up to three months before selection; Diseases that cause suppression of immunity, such as Diabetes, HIV, etc .; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the evaluation; Prediction of intense exposure to sunlight or tanning sessions during the study period; Prediction of sea baths, swimming pool or sauna during the study; Water sports during the study; Dermographism (property that has the skin of certain individuals to swell and redden in the place where it is streaked by something relatively sharp); Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the beginning of the study; Aesthetic and / or dermatological treatment on the body within 03 weeks before selection; Vaccination scheduled during the study period or up to 03 weeks before selection; History of sensitization and irritation to a topical product; Active skin pathologies (local and / or disseminated) that may interfere with the results of the study; Use of new drugs and / or health products during the study; Skin reactivity; Previous participation in studies with the same product; Known history or suspected intolerance to any ingredient in the study products (test or comparative products); History of lack of adherence or unwillingness to adhere to the study protocol; Other conditions considered by the researcher to be reasonable for disqualifying participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-3dv5t8	Comparative study between the effectiveness of Transcutaneous Electric Nerve Stimulation (TENS) and Low Power Laser devices in the scar incision in post-cesarean pain	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	3721	Comparative study between Transcutaneous Electric Nerve Stimulation (TENS) and Low Power Laser in post-cesarean section pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-3dv5t8	<NULL>	Postpartum women residing in Patos de Minas - MG, who are in the immediate puerperium (3 to 10 days postpartum), with pain at the incision site, with spinal anesthesia before the surgical procedure, absence of pathology will be included in the study genitourinary.	Patients with changes in sensitivity, demyelinating diseases, spinal cord trauma, hemorrhage, infection, fever, anesthetic complications, arterial hypertension will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:41
RBR-8969zg	Treatment of 2019-nCoV Pneumonia with N-acetylcysteine	Not yet recruiting	Intervention	2020-04-13	<NULL>	<NULL>	3745	Clinical Trial using N-acetylcysteine for treatment of 2019-nCoV Pneumonia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-14	Universidade de São Paulo	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8969zg	<NULL>	Volunteers; Both genders; Admitted to the Emergency Department with diagnosis of Acute Respiratory Syndrome, presumed or confirmed; Age equal to or greater than 18 years; Informed consent form (ICF) signed by the patient or legal guardian.	Patients with known allergy to N acetylcysteine; Pregnant women; In need of immediate mechanical ventilation or Refusal or inability to obtain consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-422bdd	Laser for healing Nipple Injuries	Not yet recruiting	Intervention	2020-04-16	<NULL>	<NULL>	3748	Low Power Laser for Healing Fissures	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Centro Universitário de Patos de Minas	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-422bdd	<NULL>	Women who are breastfeeding and have nipple cracks.	Women under 18; who are undergoing any treatment for breast fissures; who have neoplasms, pregnancy, cognitive difficulties, infected open wounds and skin with altered sensitivity, who refuse to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-9bjttc	Effect of electrical stimulation applied to the skull on response time and cognition of soccer players	Not yet recruiting	Intervention	2020-04-20	<NULL>	<NULL>	3754	Effect of Transcranial Direct Current Stimulation on Cognition and Reaction Time of soccer players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade Federal do Triangulo Mineiro	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-9bjttc	<NULL>	Individuals of 18-30 years of age; male; right-handed and left-handed; with no associated comorbidities such as orthopedic neurological and visual problems	metal-in-cranium; injuries near the electrode placement area; cardiac pacemaker in situ; intracerebral vascular clips; epilepsy; severe cognitive impairment; previous visual disturbances; depression with scores more than 8 in the Hospital Anxiety and Depression Scale (HAD).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:42
RBR-9s6tc8	A short course on Mindfulness via mobile app to reduce Stress and Anxiety in university students	Not yet recruiting	Intervention	2020-04-22	<NULL>	<NULL>	3764	A brief Mindfulness intervention with mobile App for reducing Stress and Anxiety in university students: Protocol for randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-9s6tc8	<NULL>	Volunteers of both genders between eighteen and thirty five years old; being a university student; reside in Brazil; have internet access and a cell phone with Android; be willing to download and use the Neurosaúde application on your cell phone; achieve a score greater than 0 in the symptoms of anxiety and stress measured by the subscales of stress and anxiety of the Depression, Anxiety and Stress Scale.	Volunteers who have already adopted a frequent practice of mindfulness in the past six months; who are using some type of psychotropic medication or undergoing psychological treatment during the intervention period; have a diagnosis of psychiatric or neurological illness, such as schizophrenia, borderline, panic disorder, post-traumatic stress disorder; have severe or extremely severe symptoms of depression as measured by the depression subscale of the Depression, Anxiety and Stress Scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-2j26pk	Clinical Study to Assess Anticellulite Efficacy	Not yet recruiting	Observational	2020-04-22	<NULL>	<NULL>	3765	"Clinical Study for Dermatological Evaluation of
Anti-cellulite Acceptability and Effectiveness"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Malwee Malhas Ltda,	Malwee Malhas Ltda,	https://ensaiosclinicos.gov.br/rg/RBR-2j26pk	<NULL>	"Age from 18 to 45 years; Women; Healthy participants (evaluated by the dermatologist); Phototypes I to IV (according to the Fitzpatrick classification), due to the study of acceptability and the
possibility of quickly detecting skin reactions with this scale; Presence of cellulite in the experimental region (buttocks and thighs); Presence of grade I, II, III and IV cellulite; Participants who accept not to change the normal daily routine of their cosmetic habits, except for the use of topical products with activity similar to the test product during the entire study, these do not
must be used; The Informed Consent Form (ICF) has been clarified and signed; Participants who want to participate in the study without financial profit. They will be reimbursed for expenses related to the test, such as transportation and food, among others; Participants who have not participated in similar studies for at least 2 months prior
to study; Regular / occasional users of cosmetic products similar to the product under investigation; Participants who declared they were not at risk of pregnancy during the survey period"	"Allergy to the tested product category; Pregnancy or lactation; Immunodeficiencies; Active atopic dermatitis; Kidney, heart or liver transplantation; Use of the following medications: corticosteroids, antihistamines, immunosuppressants, retinoids, anti-inflammatories; Any condition that may interfere with the evaluations according to the Investigator of the study; Participants who refuse to participate in the study in question.
Note: the participants included are instructed not to change their diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products of the same product category
tested in the experimental region"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-8qq5h9	Natural Killer imune cells expansion for Acute Myeloid Leukemia treatment.	Not yet recruiting	Intervention	2020-04-24	<NULL>	<NULL>	3771	Phase I/II clinical trial with expanded ex vivo Natural Killer (NK) cells to treat Acute Myeloid Leukemia (AML)	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-01-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-8qq5h9	<NULL>	Patients with relapsed acute myelogenous leukemia, including CNS diseases or previous hematopoietic stem cell transplantation, who have failed remission for at least one cycle of standard or experimental re-induction chemotherapy or primary refractory AML (primary AML failed to achieve remission after at least two cycles of induction therapy); Patient with high risk AML or MDS without donor for allogeneic transplantation available at the time of therapy; Patients with performance status ? 2 on Zubrod scale (ECOG) or Lansky 60; Organic function with respiratory capacity 50%, pulmonary symptoms controlled by medication and pulse oximetry greater than or equal to 92%; Creatinine ?2 mg / dL for adults, ?2 mg / dL or ?2 the upper limit of normal for age for children, or with creatinine clearance ?60 mL / min / 1.73 m2; Total bilirubin ? 2 mg / dL or TGP (ALT) &lt;2.5 x ULN for age (unless Gilbert&apos;s disease or abnormal liver function due to primary disease); Classification New York Heart Association&gt; III; Negative pregnancy test for women of childbearing age (non-fertile age defined as pre-menarche, post-menopausal over one year, or surgically sterilized); Acceptance of the use of contraceptive methods by sexually active men and women of childbearing age; Patient should have recovered from the toxicity related to previous treatment of cytotoxic agents received within 4 weeks before starting treatment in this protocol (with the exception of cytopenias resulting from persistent disease and alopecia)	Patients with high-risk AML and MDS with active, HIV-positive hepatitis B or C; With liver cirrhosis; Uncontrolled infections; Female patients with positive pregnancy test; Congestive heart failure &lt;6 months before screening; Unstable breast angina &lt;6 months before selection; Myocardial infarction &lt;6 months before selection; Non-signing free and informed consent term	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-9snttn	Effect of supplementation with the amino acid leucine and the compound Beta-hydroxy-beta-methyl-butyrate on the nutritional status, muscle mass, functionality and blood tests of patients on the waiting list for liver transplantation	Not yet recruiting	Intervention	2020-04-27	<NULL>	<NULL>	3775	Effect of Leucine and Beta-hydroxy-beta-methyl-butyrate supplementation on nutritional status, lean mass, functionality, biochemical and molecular markers of patients on the waiting list for liver transplantation	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de Minas Gerais	Santa Casa de Misericoridia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-9snttn	<NULL>	Patients on the waiting list for liver transplantation; both genders; age over 18 years	Pregnant and lactating women; vegetarians; allergic to milk and soy proteins; lactose intolerant; patients taking nutritional supplements of free amino acids; patients using progestational agents, steroids and growth hormone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-3ftcvj	Physical condition in the individual with Cirrhosis	Not yet recruiting	Intervention	2020-04-27	<NULL>	<NULL>	3776	Physical Rehabilitation in the cirrhotic individual	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-30	Danusa Rossi	Danusa Rossi	https://ensaiosclinicos.gov.br/rg/RBR-3ftcvj	<NULL>	"adults aged 18 to 70 years, both sexes, cirrhotic, with the disease stabilized, in
medical follow-up at the Liver Transplantation Clinic of Santa Casa de Porto Alegre, who accept to participate in the research."	decompensation of liver disease characterized by Child Pugh Score Class C, hospitalization in the last three months, with degenerative neuromuscular diseases and / or orthopedic changes that compromise the results of physical tests, which present absolute contraindications for testing and patients with comorbidities diseases not associated with liver disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-6w5tbk	Effects of tests for covid-19 on the preservation of the healthcare workforce during pandemia in Brazil	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3781	Effectiveness of a protocol based on rt-pcr and serology tests for sars-cov-2 for the preservation of the healthcare workforce during covid-19 pandemia in Brazil: a parallel group, randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-30	Hospital Universitário de Brasília	Cleandro Pires de Albuquerque	https://ensaiosclinicos.gov.br/rg/RBR-6w5tbk	<NULL>	Healthcare professional; directly involved in the care of patients; temporarily removed from work, because of suspected COVID-19 due to respiratory symptoms or fever	Age greater than 60 years; diabetes; cardiopathy; chronic lung disease; chronic kidney disease; onco-hematological diseases in the last five years; immunossupression; compromised general health; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-92pm68	Direct laryngoscopy or videolaryngoscopy intubation in patients without difficult airway predictors. Randomized Trial in Teaching and Training Center	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3785	Direct laryngoscopy or videolaryngoscopy intubation in patients without difficult airway predictors. Randomized Trial in Teaching and Training Center	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Hospital Central do Exército	Hospital Central do Exército	https://ensaiosclinicos.gov.br/rg/RBR-92pm68	<NULL>	Patients over 18 years old; with pre-anesthetic physical status classification according to the American Society of Anesthesiology ( ASA) 1  or 2, that is,   without functional limitation  or slight limitation.	The following factors are considered exclusion criteria: refuse of the patient or guardian; cervical spine surgery; head and neck tumors or anatomical deviations of the airway; mandibular joint disease; cervical mobility restriction; coagulation disorders; morbid obesity and risk of bronchoaspiration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-8zpnxz	Stimulation direct in the head effects in muscle fatigue in amateur runners	Not yet recruiting	Intervention	2020-04-29	<NULL>	<NULL>	3786	Transcranial direct current stimulation effects in muscle fatigue in amateur runners	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-25	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8zpnxz	<NULL>	People with 25 to 50 years old; 5 to 21 km runners training at least 2x / week and one other physical activity for at least once a week for at least six months; agree to participate in the study by the informed consent form and agree not to modify their training routine during the study period (eg modify running or weight training), but will be advised not to perform physical activity during the 24 hours preceding the study.	No medical certificate to participate in the study; Women who are pregnant or who become pregnant during the study period; Volunteers with lower limb Skeletal Muscle System injury or injured during the study period; Make use of central  drugs (antihistamine, anti-depressant, anti-epileptic);To have any metal implant in the head; No response to the resting motor evoked potential of the quadriceps muscle with the stimulation of Transcranial Magnetic Stimulation; Contraindications to the use of transcranial Direct Current Stimulation (history of convulsion, tumors or skin infection at the stimulation site, and metallic materials implanted in the brain).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:43
RBR-5x82zr	Vitamin D deficiency in children and adolescents with Type I Diabetes Mellitus: influence of vitamin D supplementation and variations in the Fok-I gen on glycemic control	Not yet recruiting	Intervention	2020-04-30	<NULL>	<NULL>	3797	Vitamin D deficiency in children and adolescents with Type I Diabetes Mellitus: influence of vitamin D supplementation and Fok-I polymorphism on glycemic control	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Rio de Janeiro	Instituto de Puericultura e Pediatria Martagão Gesteira	https://ensaiosclinicos.gov.br/rg/RBR-5x82zr	<NULL>	Age between 7 and 16 years;diagnosis of type 1 diabetes for at least 1 year	Other autoimmune diseases; sickle cell anemia; kidney or liver disease; genetic syndromes; intestinal malabsorption or hemoglobinopathies; use drugs that affect the metabolism of vitamin D, corticosteroids and insulin pump; and have recently supplemented with vitamin D.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-3k4wxb	Evaluation of the use of Hydroxychlorochine in Chinese flu	Not yet recruiting	Intervention	2020-05-05	<NULL>	<NULL>	3804	Evaluation of the use of Hydroxychlorochine in patients with discrete form of Covid-19: randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-05-01	Hospital Santo Antônio	Hospital Santo Antônio	https://ensaiosclinicos.gov.br/rg/RBR-3k4wxb	<NULL>	Positive RT-PCR; age&gt; 18 years;  discrete classification (without signs of dyspnea, and oximetry greater than 93%)	Need for ICU on day 0; allergy to hydroxychloroquine or azithromycin; retinopathy; G6PD deficiency; QT extension; lactation; pregnancy; hepatic insufficiency; acute renal failure; patients who did not sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-536yfm	Prematurity	Not yet recruiting	Intervention	2020-05-06	<NULL>	<NULL>	3812	Prematurity: risk factors and childhood development	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-536yfm	<NULL>	The studied patients will be preterm newborns; and with gestational age equal to or greater than 24; and minimum corrected age of 32 weeks; of both sexes; admitted to the Intensive Care Unit; and / or in the joint accommodation; with a current weight equal to or greater than 1500g; clinically stable; and hemodynamically; and breathing in ambient air; at the time of assessment, these being the study inclusion criteria.	Newborns with congenital malformations will be excluded; or genetic syndrome that compromises respiratory biomechanics; and congenital heart diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-4sp5w6	The effect of Botulinum Toxin type A in patients with axillary Suppurative Hidradenitis	Not yet recruiting	Intervention	2020-05-06	<NULL>	<NULL>	3813	Botulinum Toxin A for the Treatment of Hidradenitis Suppurative Axillaris: Randomized Clinical Trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade Federal de São Paulo- UNIFESP	Universidade Federal de São Paulo- UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-4sp5w6	<NULL>	"18 years old or more;
Patients with bilateral axillary hidradenitis in the stage II-III according to Hurleys classification;
At least one year with the disease;"	"Pregnant or lactating women;
Hypersensitivity to botulinum toxin
Neuromuscular diseases, such as myasthenia gravis or motor neuron disease
Use of aminoglycoside antibiotics or other drugs that interfere with neuromuscular transmission.
Patients receiving systemic treatment with immunobiological or retinoid or immunosuppressive drugs in the last 3 months.
Patients receiving oral antibiotic, or infiltration of corticosteroid or surgical intervention for hidradenitis in the treated area within 4 weeks of initiation of the study.
Patients who received botulinum toxin type A treatment in the treated area in the last 6 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-35dtsg	Body image, self-compassion and self-esteem in young university students: A preventive intervention	Not yet recruiting	Intervention	2020-05-08	<NULL>	<NULL>	3824	Body image, self-compassion and self-esteem in young university students: A preventive intervention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Cristiany Seppe Faria	Universidade Federal de Juiz de Fora campus Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-35dtsg	<NULL>	As criteria for inclusion of participants, it is pointed out to be regularly enrolled in a higher course at the IFMG of Governador Valadares; and be between 18 and 35 years old.	"Individuals who indicate a recent diagnosis and / or treatment (last 12 months) of severe psychopathologies (psychosis, risk or attempted suicide, panic disorder and post-traumatic stress disorder) will be excluded.
Individuals who do not participate in all proposed steps (pre-intervention assessment; intervention; post-intervention assessment; and two-week post-intervention assessment) will be excluded.
And participants who demonstrate that they are not attentive to the proper completion of the instruments will be excluded, being classified as random respondents through low scores on the Conscious Respondents Scale (MARJANOVIC et al., 2014)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-6ynq8f	Effect of a potassium nitrate dentifrice on tooth sensitivity caused by in-office dental bleaching.	Not yet recruiting	Intervention	2020-05-14	<NULL>	<NULL>	3835	Comparative study on the use of toothpaste with 5% potasium nitrate before the whitening process	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	San Francisco of Quito University	San Francisco of Quito University	https://ensaiosclinicos.gov.br/rg/RBR-6ynq8f	<NULL>	This trial will include adults between 18 and 30 years old, regardless of gender, with good dental and periodontal health. Specifically attention will be given to six maxillary anterior teeth, which will be required to be caries-free and without buccal restorations. Shade of central incisors will be required to be A2 or darker in a value-oriented shade guide (VITA EasyShade Advance, Vita Zanhnfabrik).	This trial will exclude participants who have previously undergone tooth-bleaching procedures, dental sensitivity, pregnancy or lactation, and severe tooth pigmentation caused by drugs, fluorosis, or pulpal pathology. Participants will also be excluded if they are taking any form of medication (especially anti-inflammatory drugs), bruxism, enamel cracks, gingival recession, class V cavities, dentin exposure, or any other clinical condition that could cause dental sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-8648fg	Dose-response effect of strength training on the rehabilitation of patients with Patellofemoral Pain Syndrome	Not yet recruiting	Intervention	2020-05-18	<NULL>	<NULL>	3839	Dose-response effect of strength training on the rehabilitation of patients with patellofemoral pain syndrome: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Nathalia Trevisol de Oliveira	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8648fg	<NULL>	Female individuals aged between 18 and 40 years, able to carry out the training and proposed evaluations and who are willing to participate in the study on a voluntary basis after the disclosure of the work on social networks on the internet. The syndrome will be diagnosed by a physiotherapy professional with experience in managing this patient profile, based on the criteria of the American Phisycal Therapy Association guidelines consensus: presence of retropatellar or peripatellar pain; pain reproduction during the squat; performance of other functional activities such as sustained knee flexion, going up or down stairs, kneeling, running.	Presence of musculoskeletal injuries in the lower limbs that prevent or impair the performance of exercises and assessment; history of physical trauma involving the knees or lower limbs, such as traffic accidents, falls, bruises, in the last twelve months; body mass index (BMI)&gt; 30; having performed a rehabilitation protocol for patellofemoral pain syndrome up to six months before data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-74683n	Efficacy of aerobic training in individuals with Parkinson&apos;s disease	Not yet recruiting	Intervention	2019-02-26	<NULL>	<NULL>	3840	Efficacy of aerobic training in immunological and neurotrophic parameters and in clinical measures in subjects with Parkinson&apos;s disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-20	Universidade Federal de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-74683n	<NULL>	"Have clinical diagnosis of idiopathic PD according to the criteria of clinical diagnosis of the
United Kingdom Parkinsons Disease Society Brain Bank (Hughes et al., 1992);
Age above 40 years;
To be in stage 1,5 to 3 of Hoehn &amp; Yahr;
Be in use of l-dopa and clinically stable;
Being able to wander independently or with the use of auxiliary devices;
Have medical release for performing aerobic training."	"To have impairment of cognitive function according to the score of the Mini-Exam of the Mental State
(cut-off point 13 for illiterate, 18 for low and medium schooling and 26 for high
schooling);
Have intense dyskinesia that interferes with postural stability;
Have other neurological and psychiatric diseases;
To present musculoskeletal changes that make difficult the accomplishment of the exercises;
To present rheumatologic diseases that interfere in the concentration of mediators
inflammatory drugs;
Have an unstable cardiovascular condition."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:45
RBR-8rtjmd	Effects of exergames and traditional exercise on anxiety in women after exposure to unpleasant stimuli	Not yet recruiting	Intervention	2020-05-19	<NULL>	<NULL>	3848	Acute Effects of Exergames and Traditional Continuous Exercise on Anxiety-State Levels in young women after exposure to Unpleasant Stimuli	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8rtjmd	<NULL>	woman; aged between 18 and 40 years old	Body mass index equal or greater than 30 kg/m2;  to be in the menstrual period; to have contraindications for physical activity; to be undergoing any kind of anxiolytic treatment; to be illiterate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-5k95vs	Effectiveness of TENS associated with vocal therapy in women with vocal disorders	Not yet recruiting	Intervention	2020-05-20	<NULL>	<NULL>	3854	Effectiveness of the application of low-frequency transcutaneous electrical nerve stimulation associated with vocal therapy in dysphonic women: clinical trial, controlled, randomized and blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5k95vs	<NULL>	women aged between 18 and 50 years old; complaint of vocal alteration; altered voice evidenced by a speech-language auditory perceptual pre-assessment; bilateral vocal nodules or mucosal thickening or edema and glottic cleft on phonation; not having used TENS for any type of treatment	women who had received speech therapy before;  over 50 years of age; who reported being or had completed menstrual flow; who reported any general neurological alterations; thyroid gland changes, who had undergone clinical treatment for hormonal control (except contraceptive pill); vocal or surgical laryngeal treatment; heart problems, high blood pressure, hyper or hypothyroidism; smokers; alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-3z3w3n	Effects of probiotic use in diabetic patients with periodontal disease	Not yet recruiting	Intervention	2020-05-22	<NULL>	<NULL>	3862	Analysis of the clinical profile of diabetic patients with periodontitis before and after probiotic therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z3w3n	<NULL>	Presence of at least 15 natural teeth, excluding third molars and teeth indicated for extraction; diagnosis of generalized stage III grade C periodontitis, with more than 30% of the sites with probing depth and clinical level of insertion greater than or equal to 4 mm and bleeding on probing of at least 30% of the teeth; presence of type II diabetes mellitus diagnosed at least 5 years ago, with glycated hemoglobin levels between 7% and 11%, treatment with diet and supplementation with insulin or hypoglycemic agents; presence of a good state of general health with the exception of diabetes mellitus.	Presence of other systemic conditions, with the exception of diabetes mellitus, which can affect the progression of periodontitis or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and / or use of antimicrobials in the last 6 months; use of probiotics in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; extensive prosthetic rehabilitation; tobacco consumption in the last 5 years; pregnancy and lactation; diabetic complications, such as nephropathy, neuropathy, and peripheral cardiovascular and vascular diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:46
RBR-2jnx4s	Effect of ear acupuncture on nursing professionals with stress, anxiety and depression	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3869	Effectiveness of auriculoacupuncture on stress, anxiety and depression in nursing professionals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2jnx4s	<NULL>	Nursing professionals with moderate, severe and extremely severe levels of stress, anxiety and depression, assigned to each sector, with availability to answer questions and scale and participate in the intervention, if selected.	Individuals with infection, inflammation or injury in the ear, use of ear piercing (except for normal earring), allergy to metal or microporous tape; subjects who have some PIC for anxiety, stress and / or depression, being pregnant, being in the puerperium and / or breastfeeding; refuse to receive ear treatment using needles.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-9b78kj	Effect of Acai consumption on variables related to muscle damage induced by exercise in active individuals.	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3871	Effect of consumption of Acai (Euterpe oleracea Mart.) on late pain, recovery and exercise-induced muscle damage: clinical, randomized, crossover, double-masked, and controlled placebo study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9b78kj	<NULL>	Age between 18 and 50 years; practice physical exercise for at least six months; and be available to participate in the study.	present intolerance / aversion to açaí; use alternative treatments to reduce late pain (acupuncture, cryotherapy, anti-inflammatory drugs, analgesics, among others); you are a smoker; present a weight change greater than 10% in the last three months; have chronic (cardiovascular, renal, liver, intestinal), infectious, inflammatory or acute illnesses that have required treatment in the past two months; having had cancer in the past ten years; chronic use of medication, except contraceptives; make use of anabolic steroids; use nutritional supplements, except supplements based on carbohydrates and proteins; is in gestational or breastfeeding period; has undergone surgical intervention to treat obesity; and is not available to participate in the meetings regarding the intervention and data collection of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-2gbqfx	Study on the correct use of drugs in patients with infarction	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	3873	Medication adherence in patients with a history of Myocardial Infarction: randomized clinical trial	<NULL>	2-3, single-arm-study, open	2-3	<NULL>	<NULL>	<NULL>	2020-08-03	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2gbqfx	<NULL>	Patients with myocardial infarction; both genders; age over 18 years; using cardioprotective drugs; social referent responsible for organizing and taking pills	Patients without conditions for effective oral verbal communication; diagnosed with mental disorders; social referent who cannot be present in the interviews	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-3cjbq5	Microneedling effect on male baldness.	Not yet recruiting	Intervention	2020-05-26	<NULL>	<NULL>	3875	Randomized comparative single blinded clinical trial on the effectiveness and safety of microneedling in the treatment of androgenetic alopecia.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Hospital São Paulo	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3cjbq5	<NULL>	Signature of Written Informed Consent Form and Authorization for Photographs Term prior to any study procedure; men aged between 18 and 60 years, in good health; Clinical diagnosis of moderate male androgenet alopecia (Stage IIIa-IV of the Norwood-Hamilton Scale) with disease onset time less than 10 years; accordance with the conditions of the study, ability to understand and strictly follow the therapeutic guidelines received and availability to attend periodic evaluations.	Men who do not agree with the conditions of the study or who are unable to understand and strictly follow the therapeutic guidelines received, are not available to attend periodic evaluations or refuse to sign the Written Informed Consent Form and Authorization for Photographs Term; patients suffering from other alopecias, including telogen effluvium; patients with mild disease (stages I and II) or severe disease (stages V to VII of the Norwood-Hamilton Scale); patients who have androgenetic alopecia for more than 10 years; previous use of finasteride or dutasteride in the last 6 months; patients with a current or previous history of malignant or pre-malignant tumors of the scalp; patients that suffer from allergic contact dermatitis to propylene glycol (minoxidil vehicle), minoxidil, tattoo ink, topical or local anesthetic; patients that have dermatoses that may worsen due to the procedure and interfere with the evaluation, such as psoriasis, vitiligo; patients receiving chemotherapy, radiation therapy, corticosteroids or other immunosuppressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-22rb9m	Risk factors related to nonuse to the new lower complete denture	Not yet recruiting	Intervention	2020-05-28	<NULL>	<NULL>	3886	Risk factors related to difficulty in adaptation to new mandibular complete denture	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-30	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-22rb9m	<NULL>	Bimaxillary edentulous, need for new conventional complete dentures, absence of intraoral lesions, absence of changes in the perioral musculature.	Debilitating health that makes rehabilitative treatment unfeasible, unsatisfactory cognitive and systemic ability that compromises the analysis of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:47
RBR-7jdjcf	Photobiomodulation in burn patients	Not yet recruiting	Intervention	2020-06-01	<NULL>	<NULL>	3891	Use of phototherapy on autograft viability in burned participants	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2020-08-10	Universidade Federal do Ceará	Instituto Doutor José Frota(IJF)	https://ensaiosclinicos.gov.br/rg/RBR-7jdjcf	<NULL>	Adults between 18 and 59 years old, male and female; participants accompanied at the IJF at the Burn Center, who have deep second and third degree burns; individuals with indication of graft.	"diabetic people; people with signs and symptoms indicative of an infectious process; individuals with signs of hypoproteinemia or anemia; grades II and III obese individuals; people using corticosteroids (interference with healing); people
with cognitive changes (mini mental below 24 points)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-7p58r6	Effects of laser therapy on orofacial muscles	Not yet recruiting	Intervention	2020-06-02	<NULL>	<NULL>	3895	Effects of photobiomodulation on orofacial muscles	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7p58r6	<NULL>	Age between 18 and 60 years; sign the Informed Consent Form	craniofacial anomaly; use of myorelaxing and/or anti-inflammatory drugs; signs and/or symptoms of temporomandibular disorder; photosensitivity; pregnancy; glaucoma; undiagnosed lesion on the area to be irradiated or close to it; infection at the application site; history of cancer; use of a pacemaker or other electronic implant; presence of a beard or mustache at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-2dxyx4	Mechanical ventilator for use in patients with respiratory failure due to Covid-19 (VExCO)	Not yet recruiting	Intervention	2020-06-02	<NULL>	<NULL>	3896	Mechanical ventilator for use in patients with respiratory failure due to Covid-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-04	Hospital Universitário Clementino Fraga Filho	Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia	https://ensaiosclinicos.gov.br/rg/RBR-2dxyx4	<NULL>	Adults between 18 and 70 years of age who are submitted to mechanical ventilation in a regular ventilator in controlled or assisted-controlled mode, sedated or curarized or anesthetized, clinically stable, with arterial oxygen saturation continuously monitored	"Patients under the age of 18 or over 70;
ventilated patients who are not on assisted-controlled ventilation or controlled ventilation in PCV mode (pressure-controlled ventilation); patients whose arterial oxygen saturation (SaO2) is less than 95%; patients whose ventilatory adjustments are above the following limits: positive end-expiratory pressure (PEEP) of 15 cmH2O; respiratory rate (RR) of 25 cycles per minute; driving pressure (dP = plateau pressure (Plateau) minus PEEP) of 15 cmH2O; inspiratory oxygen fraction (FiO2) of 60%;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-3k6982	Evaluation of irritability and sensitization of health products, through the contact test.	Not yet recruiting	Observational	2020-06-03	<NULL>	<NULL>	3904	"Assessment of primary skin irritability,
accumulation and awareness of products for
through the contact test."	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-06-29	Makelab Consultoria Eireli	Labterapi Laboratório de produtos naturais EIRELI EPP	https://ensaiosclinicos.gov.br/rg/RBR-3k6982	<NULL>	Women; Age: 18 to 65 years; Phototype: I to IV; Whole skin of the region; Occasional user of products of the category	"Participants who refuse to participate in the study in question; Skin marks in the experimental area that interfere in the evaluation of possible skin reactions; Active dermatoses (local and disseminated) that may interfere with the results of the study; Pregnant or lactating women; History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines; Volunteers with a history of allergy to the material used in the study; Background of atopy; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; Discharges; History of pathologies aggravated or triggered by ultraviolet radiation; Immunodeficiency sufferers; Kidney, heart or liver transplantation; Forecast of intense sun exposure or tanning session during the period
conducting the study; Forecast of bathing in the sea, pool or sauna during the study; Participants who practice water sports; Use of the following medications for systemic topical use: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Treatment with acidic vitamin A and / or its derivatives orally or topically up to 01 month before the beginning of the study; Vaccination forecast during the study or up to 03 weeks before the study; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-772s6y	Study of efficiency and effectiveness of a new family of introcular lenses	Not yet recruiting	Intervention	2020-06-04	<NULL>	<NULL>	3909	Study of the effectiveness and efficiency of a new family of single-focal and multifocal introcular lenses under the Customized Cataract Solution project	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-06-01	João Marcelo de Almeida Gusmão Lyra	MediPhacos Industrias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-772s6y	<NULL>	Patients who had a clinically documented diagnosis of age-related cataract (cortical, nuclear, sub-capsular or a combination) that was considered amenable to treatment by extraction of the cataract using the intracapsular facectomy method. Adult patients 21 years of age or older. Patients eligible for primary intraocular lens implantation. Patients willing and able to perform clinical and complementary exams for follow-up for a minimum of 1 year after cataract surgery. Patients requiring intraocular lens implantation powers ranging from 10 to 30 diopters. Patients with visual potential of 20/40 or better in the eye indicated for intraocular lens implantation. Patients with corneal cylinder to correct less than 1 diopter.	"Patients with the best corrected visual acuity less than or equal to 20/200 in the contralateral eye.
Patients with any pathology of the anterior segment in which the intracapsular facectomy procedure with primary IOL implantation is contraindicated (examples: keratoconus, corneal dystrophies or scars, anterior uveitis).
Patients with corneal inflammation or edema, included and not limited to: keratitis, keratoconjunctivitis and keratitis.
Patients with uncontrolled glaucoma or glaucoma under treatment.
Patients with a history of retinal detachment.
Patients with diabetic retinopathy (proliferative or non-proliferative).
Patients with congenital, metabolic, traumatic or complicated cataracts.
Patients with marked microphthalmia or aniridia.
Patients who have had previous proposed eye surgery.
Patients who have already received another IOL in the contralateral eye.
Irregular astigmatism of the cornea.
Amblyopia.
Clinically significant changes in the retinal pigment epithelium / macula.
Neovascularization of the iris, camerular and retinal angles.
Severe recurrent inflammation of the anterior or posterior segment of unknown etiology.
Optic atrophy.
Patients with immunodeficiency (infectious, neoplasic or medicated)
Patients on chronic use of systemic steroids or immunosuppressive drugs.
Patients participating in another clinical trial simultaneously.
Patients with strong dependence on intermediate vision, night vision or specific occupational requirements (examples: commercial pilots and professional drivers)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:48
RBR-2vfqnz	Clinical study to evaluate the effect of sublingual gel melatonin in healthy research participants	Not yet recruiting	Intervention	2020-06-08	<NULL>	<NULL>	3916	Monocentric phase I clinical study to assess the tolerability, safety and pharmacokinetics of sublingual melatonin gel in healthy research participants (PPES 003/19)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Instituto de Ciências Farmacêuticas	Instituto de Ciências Farmacêuticas	https://ensaiosclinicos.gov.br/rg/RBR-2vfqnz	<NULL>	Participant of both sexes, aged 55 or over. Survey participant with laboratory results, type 1 urine examination, clinical evaluation, vital signs, and ECG within normal range and / or any deviation from normality classified as not clinically significant.	Complementary test results are 3 times higher than normal values unless clinically irrelevant. Women who are breastfeeding. Participant with a history of hypersensitivity to the study drug or chemically related compounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4mw25f	Effect of Transcranial Direct Current Stimulation on the physical conditioning of children and adolescents with Cerebral Palsy.	Not yet recruiting	Intervention	2020-06-10	<NULL>	<NULL>	3918	Effect of Transcranial Direct Current Stimulation on the physical fitness of children and adolescents with Cerebral Palsy: a crossover, placebo-controlled, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-4mw25f	<NULL>	The participants included in the study will be children and adolescents with a diagnosis of CP of the spastic diparesis type confirmed through clinical examination; having magnetic resonance imaging showing damage to the pyramidal system, without compromising the extrapyramidal system and cerebellum; age between seven and twelve years; GMFCS level one, two and three children; children who have sufficient strength to overcome gravity and complete the range of motion of the joint regarding the flexor and extensor muscles of the trunk, hips and knees; degree of spasticity less than three on the Modified Ashworth Scale; present degree of joint mobility of the ankle compatible with positioning in a neutral position, popliteal angle below thirty degrees and Thomas test with hip flexion below twenty degrees; consent of those responsible by signing the Informed Consent Form.	Children who are diagnosed with epilepsy or who have had seizures at least twelve months before the start of the study will be excluded; who have neurological, neuromuscular diseases or syndromes associated with brain injury; who have undergone orthopedic or neurological surgery in the twelve months prior to the intervention; who have undergone neurolytic blocks in the six months prior to the intervention; who have orthopedic deformities with surgical indication; who have brain implants or who have undergone a neurosurgical procedure; who have metallic implants in the head, neck, chest and / or upper limbs regions; who have hearing aids; children with a degree of collaboration incompatible with adequate performance in the activities proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-2jv3sy	Positioning of the gastric tube in newborn	Not yet recruiting	Intervention	2020-06-15	<NULL>	<NULL>	3925	Randomized clinical trial on gastric tube placement in newborns using three measurement methods	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-15	Escola de enfermagem da Universidade Federal de Minas Gerais	CNPq	https://ensaiosclinicos.gov.br/rg/RBR-2jv3sy	<NULL>	Newborns; Admission to the Neonatal Progressive Care Unit; indication of gastric catheterization; clinical stability	Children with complex malformations; gastrointestinal tract malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-4n3cg2	Evaluation of quality of life with voice and difficulty swallowing in patients undergoing surgery to remove the entire larynx for cancer	Not yet recruiting	Observational	2020-06-19	<NULL>	<NULL>	3927	Voice quality of life and dysphagia in patients undergoing total laryngectomy with speech rehabilitation: prosthesis, esophageal voice, and electronic larynx: a multicenter study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Giulianno Molina de Melo	Real e Benemérita Associação Portuguesa de Beneficência/SP	https://ensaiosclinicos.gov.br/rg/RBR-4n3cg2	<NULL>	patients undergoing total laryngectomy with primary speech rehabilitation within a minimum of six months after surgery; patients undergoing total laryngectomy with secondary speech rehabilitation six months after insertion when surgery and radiotherapy; patients undergoing total laryngectomy with speech rehabilitation with esophageal voice six months after surgery and radiation therapy; patients undergoing total laryngectomy with speech rehabilitation with electronic larynx six months after insertion when surgery and radiotherapy; patients without evidence of disease; patients capable of phoning regardless of vocal quality; patients able to read, understand and answer the QOL questionnaire; patients who agreed to participate in the study by filling out a questionnaire voluntarily	patients with tumor recurrence or persistence; patients with other than total laryngectomy; lost follow-up patients; patients who refused to participate in the study; patients with death due to illness within 6m after answering the questionnaires; patients with a follow-up of fewer than 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-48z4vp	Effects of Water Therapy on risk of falls in older people	Not yet recruiting	Intervention	2019-07-03	<NULL>	<NULL>	3930	Effects of Aquatic Physical Exercise on falls and risk factors in community-dwelling older people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-19	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-48z4vp	<NULL>	Ability to walk alone; reported initial availability of attending the training twice a week; not being engaged for five or more times per week in one or more of the activities walking, running, cycling, swimming, aerobic exercise, dancing, gardening or weight lifting.	Any cardiovascular or infectious disease present in the list of the absolute contraindications described in the Physical Activity Readiness Medical Examination; score in the Mental State Mini-exam below the cut-off point designated by level of schooling minus one standard deviation; to present a motor sequelae of stroke and neurological diseases that interfere with cognition or mobility; urinary incontinence; open wounds; sensitivity to chemicals used in swimming pool; severe and uncorrected audiovisual disturbance that makes communication difficult during the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:49
RBR-2d3sf9	Effect of laser auriculotherapy on signs and symptoms of patients with problems in the chin joint.	Not yet recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3940	Effect of low-power laser auriculotherapy on signs and symptoms of patients with muscular temporomandibular disorder. A comparative study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-30	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2d3sf9	<NULL>	"Adult volunteers aged 18 years or over;
score equal to or greater than 3 in the
Triage Questionnaire of the American
Academy of Orofacial Pain; with the
presence of myofascial pain according to
the Research Diagnostic Criteria for
Temporomandibular Disorders (RDC /
TMD)."	"Volunteers with non-painful
temporomandibular disorder according to
RDC / TMD; patients with associated
diseases: fibromyalgia, facial paralysis,
rheumatoid arthritis, mental illness or
cognitive deficits that would impede the
understanding of some of the stages of the
research; pregnant women; with external
ear injuries or with immunodepression;
carriers of clotting disorders, metabolic,
vascular or neoplastic diseases; volunteers
submitted to other types of associated
therapies - interocclusal apparatus,
psychotherapy, physiotherapy, orthodontics,
alternative therapies; volunteers who use
continuous medication (analgesics, antiinflammatories,
muscle relaxants,
antidepressants / anxiolytics,
anticonvulsants)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-992839	The use of therapeutic paracetamol ice cream in the postoperative period of children: a randomized clinical trial	Not yet recruiting	Intervention	2020-06-23	<NULL>	<NULL>	3943	The use of an Emulsion formula of the type Therapeutic Ice Cream Of Paracetamol in the children&apos;s Post-Operatory: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	Centro Universitário Luterano De Palmas - CEULP/ULBRA	Universidade Luterana Do Brasil - ULBRA	https://ensaiosclinicos.gov.br/rg/RBR-992839	<NULL>	Children aged 6 to 12 years; Conditioned children (collaborators); Children with indication of extraction on any deciduous or permanent teeth; Of both sexes (male and female); Children who have signed the free and informed consent term (TALE ); Children whose legal guardian has signed the informed consent form (ICF)	Children with sensitivity to the components of the paracetamol / ice cream formulation; Children under 6 years of age; Children with lactose intolerance.; Children with cognitive development disorders; Children with heart disease; Children with liver disease; Children with kidney disease; Children with coagulopathy; Children with diabetes; Children unaccompanied by their legal guardian.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-3hvsy5	Single implant-retained removable mandibular complete denture: non randomized controlled clinical study	Not yet recruiting	Intervention	2020-06-24	<NULL>	<NULL>	3947	Single implant-retained mandibular overdenture: non-randomized controlled clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3hvsy5	<NULL>	Patients must be 60 years or older, good general health status, absence of intraoral lesions, and changes in the perioral muscles detected by palpation. Patients whose implants can be placed in the mandible without bone graft (minimum bone height of 8 mm), user of the upper conventional complete denture, use or nonuse the lower complete denture, and need new conventional complete dentures.	Edentulous with local bone deficiency, systemic disease that prevents implant placement, history of chemotherapy or radiotherapy, users of bisphosphonate drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-2d2vb9	Pilates in patients with Persistent Pain	Not yet recruiting	Intervention	2020-06-26	<NULL>	<NULL>	3955	Pilates in patients with Chronic Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Faculdade de Medicina da Universidade Federal do Ceará	Faculdade de Medicina da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2d2vb9	<NULL>	The study will include individuals aged between 18 and 60 years, of both sexes, who have had low back pain for more than 12 weeks.	Individuals contraindicated for therapeutic exercise, according to the Physical Activity Readiness Questionnaire, who underwent treatment with Pilates in the last 3 months, pregnant women, severe spinal pathologies (example: fracture, tumor, infection), previous spinal surgery and lower limbs, inflammatory, rheumatic or neurological disorders, nerve root involvement, osteoporosis, inability to understand written or spoken Portuguese and who has received physical therapy in the past 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-5kkpg6	Effect of eating habits and exposure to light on sleep, emotion, memory and headache in college students during the COVID-19 pandemic	Not yet recruiting	Intervention	2020-06-28	<NULL>	<NULL>	3961	Interaction of food and light synchronization on sleep aspects, cognition and headache in college students during the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-29	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5kkpg6	<NULL>	College students regularly enrolled in higher education institutions; both sexes, between 18 and 30 years of age; in social isolation, leaving your home only for essential activities.	Students from colleges, originally with a distance learning method; students from international colleges.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-7jqpnw	Effect of COVID-19 convalescent plasma produced by HEMOPE: A randomized study, with a comparative group in several centers	Not yet recruiting	Intervention	2020-06-29	<NULL>	<NULL>	3963	Therapeutic effectiveness of COVID-19 convalescent plasma produced by HEMOPE: a multicenter, randomized and controlled clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7jqpnw	<NULL>	adults&gt; 18 years with diagnosis of COVID – 19, who are hospitalized; and considered as having a condition that increases the risk of a worse prognosis: obesity; diabetes mellitus (DM); systemic arterial hypertension (SAH); chronic lung disease, obesity, diseases that alter immunity (AIDS, neoplasms or autoimmune diseases in immunosuppressive therapy, chronic liver disease.	History of anaphylactic reaction related to blood transfusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:50
RBR-8yb47v	Effects of two exercise programs on pain, functionality and running pattern in runners with anterior knee pain	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	3976	Effects of two gait retraining programs on pain, functionality and lower limb kinematics in runners with patellofemoral pain: a randomized clinical trial with 6-months follow-up.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8yb47v	<NULL>	Rearfoot runners with step rate under 170 steps/minute, age between 18 and 45 years, minimum pain levels of 3/10 on the Visual Analogue Scale (VAS) during running and one task among squatting, climbing, and descending steps, kneeling, and extending the knee with resistance, and being comfortable running at a speed of 10-12 km/hour.	Other diseases in the lower limbs, history of surgery in the lower limbs in the last year, and not showing interest to adhere to a strict running retraining protocol for 2 weeks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-5t258m	Analysis of Salivary Constituents of Elderly Patients with Gingivitis After Use of Dentifrice Incorporated with Brazilian Red Propolis	Not yet recruiting	Intervention	2020-07-09	<NULL>	<NULL>	3992	Analysis of Salivary Biomarkers in Elderly Patients with Gingivitis After Use of 1% Brazilian Red Propolis Based Dentifrice: A Randomized Clinical Trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5t258m	<NULL>	Healthy volunteers; both genders; presence of gingivitis; age over 65 years; presence of at least five dental elements.	Smoking volunteers; history of alcohol or drug abuse, presence of cognitive problems; dependency on caregiver for daily activities; professional application of fluoridated products in the last 3 months; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:51
RBR-92g625	Aesthetic treatment of stains on anterior teeth caused by hypomineralization	Not yet recruiting	Intervention	2020-07-10	<NULL>	<NULL>	3999	Masking enamel demarcates opacities in anterior teeth in patients with Molar-Incisor Hypomineralization: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-25	Universidade do Estado do Rio de Janeiro -UERJ	Universidade do Estado do Rio de Janeiro -UERJ	https://ensaiosclinicos.gov.br/rg/RBR-92g625	<NULL>	The sample will be composed of children and adolescents, between 7 and 18 years old, with MIH, presenting white-creamy opacities in the enamel of at least one incisor	Patients with other dental developmental defects such as amelogenesis, dentinogenesis imperfecta or fluorosis; Patients with fixed orthodontic appliance; Patients with chronic health syndromes or health impairments that requires special care during dental treatment; Incisors with caries lesions or with demarcated opacities of other origins, such as traumatic sequelae in the predecessor primary teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-8zfn5c	Effect of daily consumption of Castanha-do-Pará (BERTHOLETIA EXCELSA, HBK) on weight loss, metabolism, appetite, food intake, metabolism regulators and genetic markers	Not yet recruiting	Intervention	2020-07-10	<NULL>	<NULL>	4000	Effect of Brazil Nuts (BERTHOLETIA EXCELSA H.B.K) daily consumption on weight reduction and body composition, energy metabolism, appetite, food intake, metabolic regulators and genetic markers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-17	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8zfn5c	<NULL>	Adult women aged 20 to 55 years; excess body fat (equal or greater than 32%) and high waist circumference (equal or greater than 80 cm); overweight (BMI equal or greater than 27 kg/m2) associated with at least one more component of the Metabolic Syndrome, which means triglycerides equal or greater than 150 mg/dL, blood pressure equal or greater than 130 and/or  85 mmHg for systolic and diastolic pressures, respectively, or fasting glucose equal or greater than 100 mg / dL) or; obesity (BMI equal or greater than 30 kg/m2) regardless of the presence of the other components of the Metabolic Syndrome	Women younger than 20 years or older than 55 years; body fat percentage less than 32%; waist circumference less than 80 cm; BMI below 27 kg/m²; BMI between 27 and 30 kg/m², without the presence of any other component of metabolic synddrome, pregnant women, nursing mothers, or menopausal women; athletes; smokers; with a history of HIV, digestive alterations, hepatic or renal diseases, cardiovascular diseases, hypo or hyerthyroidism, cancer, inflammatory diseases and eating disorders; history of drug and/or alcohol abuse; aversion or allergy to nuts; infectious episode in the last month; use of anti-inflammatory drugs, corticosteroids, antibiotics and others that can affect appetite and energy metabolism; weight instability (5% of usual weight) in the last 3 months; daily consumption of nuts (greater than 5g for Brazil nuts and greater than 30 g/day for other nuts); alcohol consumption higher than 21 units (168g) per week; dental problems that interfere with chewing; consumption of vitamin, mineral and omega 3 supplements in tha last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-3ksq2c	Immediate effects of Spinal Manipulation  on pain and balance in individuals with Chronic Low Back Pain	Not yet recruiting	Intervention	2020-07-13	<NULL>	<NULL>	4002	Immediate effects of Vertebral Manipulation on painful sensitivity and postural stability of individuals with Chronic Low Back Pain - randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Centro Universitário Augusto Motta	UniGuairacá Centro Universitário	https://ensaiosclinicos.gov.br/rg/RBR-3ksq2c	<NULL>	Low back pain lasting at least three months; score on the numerical pain scale of at least 3 points at the time of assessment; age between 18 and 59 years; hypomobility in at least one lumbar vertebral segment verified during the physiotherapeutic evaluation through the posteroanterior pressure test in the prone position (Spring Test); symptoms that do not extend beyond the knee; absence of neuropathic pain components assessed using the painDETECT questionnaire.	Chronic widespread pain; ligament laxity or hyper flexibility; pregnancy; conditions that contraindicate the use of vertebral manipulation techniques at high speed and low amplitude (red flags) such as vertebral fractures, cauda equina syndrome, cancer, inflammatory rheumatic diseases, vertebral infections, bone tuberculosis; any condition that may interfere with pain sensitivity measures, for example, changes in skin sensitivity, neurological diseases, psychiatric diseases or fibromyalgia; any condition that interferes with body balance, for example, neurological diseases or vestibulopathy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-22k94c	Effectiveness of Active Video Games in adherence to ambulatory Cardiac Rehabilitation: randomized clinical trial	Not yet recruiting	Intervention	2020-07-16	<NULL>	<NULL>	4012	Effectiveness of Exergaming in adherence to Cardiac Rehabilitation Phase II: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-11	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-22k94c	<NULL>	Heart disease patients, of both sexes, over 18 years old, with medical clearance to perform CR.	Patients who had very recent acute myocardial infarction (less than 72 h); unstable angina (less than 72 h from stabilization); severe symptomatic valvular heart disease, with surgical indication; uncontrolled arterial hypertension: SBP greater than 190 mmHg and / or DBP greater than 120 mmHg; decompensated heart failure; complex ventricular arrhythmias; suspected left or unstable or severe coronary artery injury; infective endocarditis, myocarditis, pericarditis; severe, uncorrected, symptomatic congenital heart diseases; pulmonary thromboembolism and acute thrombophlebitis; aortic dissection - type A or acute phase type B; severe symptomatic obstruction of the left ventricular outflow tract with low effort-induced output; uncontrolled diabetes mellitus; acute systemic infectious condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-8jbwf5	Influence of physical exercise in children with Asthma	Not yet recruiting	Intervention	2020-07-20	<NULL>	<NULL>	4019	Influence of aerobic exercise in children with Asthma diagnosis	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-05-15	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8jbwf5	<NULL>	Children; 8 and 12 years old; diagnosis of intermittent, persistent mild or moderate asthma; pharmacological treatment (corticosteroids or B2-agonists); regularly follow up with a pulmonologist in Campo Grande- MS	Interrupt medical care and/or drug treatment; manifest other acute or chronic pathological conditions; those who miss more than 20% of rehabilitation sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-25jpgt	Influence of Physical Exercise on pain modulation and on psychological, social and behavioral aspects in patients with Chronic Pain of masticatory muscles	Not yet recruiting	Intervention	2020-07-20	<NULL>	<NULL>	4022	Influence of an Individualized Physical Exercise Program on the endogenous pain modulation profile and on the psychosocial and behavioral aspects in patients with Chronic Myofascial Masticatory Pain: a controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-25jpgt	<NULL>	Healthy volunteers; of both genders; aging between 18 and 40 years; who do not report the presence of any persistent pain condition in the last 6 months; volunteers diagnosed with myofascial pain according to the DC/TMD; with pain duration greater than or equal to 3 months and with pain report in the last 15 days; primary complaint of pain in the area of the masseter and/or temporal muscles, with the presence of simultaneous pain in the preauricular area being accepted as a secondary complaint	Pregnant women; lactating; high-performance athletes; active individuals by the IPAQ questionnaire; individuals in physical training; individuals with chronic generalized pain, individuals with fibromyalgia, or neurological diseases; high blood pressure and other cardiovascular problems; psychiatric conditions; use of analgesics, antidepressant drugs, membrane stabilizers, benzodiazepines, or any other medication with CNS action; positive answer to one or more questions in the PAR-Q Questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:52
RBR-49hcnx	Evaluation of the efficacy of multiple stiches as a method of controlling local bleeding in patients using oral anticoagulants: randomized clinical trial	Not yet recruiting	Intervention	2020-07-23	<NULL>	<NULL>	4031	Evaluation of the efficacy of mass suture as a method of local hemostasis in patients using warfarin: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Faculdade de Odontologia da Universidade de São Paulo	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-49hcnx	<NULL>	Volunteers who are being monitored at InCor / HCFMUSP; using oral anticoagulant (warfarin) only as the only medication capable of altering blood clotting and bleeding time; TP / INR (2.0-4.0), accepting to participate in the study; allow clinical examination; present bilateral upper permanent teeth with indication of extraction.	Patients with PT / INR outside the range defined by the study (2-4); patients using drugs such as antiplatelet agents in association with warfarin; with coagulopathies; with liver disease; with thrombocytopathies and thrombocytopenia; toothless upper patients; patients who do not have an indication for extraction; patients who do not accept to participate in the research for any reason.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-6f5xbq	Study of treatment discontinuation of chronic myeloid leukemia in the Unified Health System	Not yet recruiting	Intervention	2020-07-24	<NULL>	<NULL>	4032	Efficacy and efficiency of discontinuation of treatment with tyrosine kinase inhibitors in patients with chronic myeloid leukemia treated in the Unified Health System after obtaining a sustained deep molecular response	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2020-08-01	Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas	Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6f5xbq	<NULL>	"Patients with chronic CML; 18 years or older (WHO 2008); treated with TKI for more than 3 years; who have already had a complete cytogenetic response; typical BCR-ABL transcripts (b3a2 and / or b2a2)
Patients with an RM4.5 response (PCR less or equal to 0.032%) sustained for 2 years. The patient must have 4 PCR tests in this period, confirming these results, 2 in the last 6 months.Mandatory use of contraceptive methods for women of childbearing age"	Accelerated or previous blast phase; previous bone marrow transplant; resistance-related BCR-ABL1 mutations; BCR-ABL1 transcripts not measurable by quantitative PCR (unknown initial transcripts; atypical transcripts, such as p190 and others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-8hmb2r	Studying the progression and the consequences of the new Coronavirus in Brazil	Not yet recruiting	Observational	2020-07-27	<NULL>	<NULL>	4038	Multicenter study of the natural history of the new Coronavirus SARS-CoV-2 in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-08-03	Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)	Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)	https://ensaiosclinicos.gov.br/rg/RBR-8hmb2r	<NULL>	"Age equal to or greater than 18 years;
Patients with fever and/or respiratory symptoms within 7 days;
Contacts of patients with a flu-like syndrome"	"Patients who are unable to participate in study visits.
Patients with severe mental disorders or those from whom the collection of information due to communication disorders or lack of fluency in Portuguese or another language understood by the attending physician is impossible."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-5ysj54	BCG vaccine use to prevent COVID-19 in health care workers	Not yet recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4047	BCG vaccine as preventive measure against COVID-19 in health care workers	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-07-15	Universidade Federal do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5ysj54	<NULL>	Individuals aged above 18 years old, male or female, not infected with SARS-CoV-2 who exercise professional activities in the Health Units of the study; Agreement to participate in the study by signing the informed consent form	Professionals with a history of infection confirmed by SARS-CoV-2 or who have already been diagnosed with COVID-19 prior to the study; Individuals who have not performed confirmatory tests for COVID-19; Pregnancy or breast-feeding; Non-permanence in activities in the Health Units after 6 months of enrollment in the study; Individuals with primary or acquired immunodeficiency; Individuals with malignant neoplasms; Patients on high-dose corticosteroids (equivalent to a prednisone dose of 20 mg / day or more) for more than two weeks; Patients using other immunosuppressive therapies (antineoplastic chemotherapy, radiation therapy, among others); Individuals with autoimmune diseases;  Dermatological disorders at the vaccine site or generalized; Individuals under treatment for active tuberculosis; Individuals with report of fever (axillary temperature&gt; 38 ° C in the last 48h)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-7xpmy5	Safety and tolerance in the use of Shock Wave Therapy in people with upper limb lymphedema after breast cancer treatment	Not yet recruiting	Intervention	2020-07-27	<NULL>	<NULL>	4050	Safety and tolerance of the use of Shockwave Therapy in Lymphedema secondary to the treatment of Breast Cancer	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2020-08-01	Patricia Lima Ventura	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xpmy5	<NULL>	Women over 18; Women with lymphedema secondary to unilateral breast cancer surgery with an axillary approach (considered lymphedema when there is a difference in perimetry bigger or equal 2.00 cm in at least one point on the affected upper limb in relation to the contralateral one);Those who have undergone complex physical therapy (CFT) in the last year and have controlled lymphedema (with no changes in the last 30 days);Those who agree to participate in the research and sign the Informed Consent Form.	Those with local or remote recurrence;Women with bilateral breast cancer;Those undergoing chemotherapy or radiation therapy;Women with a postoperative period less than six months after the axillary approach; Presence of dermal changes (local signs and symptoms such as hyperemia, hyperthermia, hyperpigmentation, pustules and other skin changes); Report of autoimmune diseases (dermatomyositis, nephropathy, lupus erythematosus, morphea, psoriasis, pemphigus vulgaris, scleroderma); Report of osteomioarticular disease in a member homolateral to the surgery; Women with amputation of a limb; Be illiterate or have difficulty reading and interpreting text;Cognitive and psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:53
RBR-2x4hqm	Use of new technologies for the treatment of vaginal sequelae caused by radiotherapy.	Not yet recruiting	Intervention	2020-07-28	<NULL>	<NULL>	4057	Use of non-ablative radiofrequency and intravaginal CO2 laser in the treatment of genitourinary syndrome following cervical carcinoma radiotherapy: a pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-06	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul	Fundo de Incentivo à Pesquisa do Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2x4hqm	<NULL>	Women over 18 years old, up to 50 years old, treated with external radiotherapy in the last 5 years, with genitourinary complaints, without residual tumor lesions and who accept to participate in the study, being informed about the procedures to be performed	Metastatic disease, tumor recurrence, previous treatment of genitourinary symptoms in the last month, presence of genital infection at the beginning of treatment, and women with collagenosis or HIV (Human Immunodeficiency Virus).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-3g5f9f	Educational intervention by cell phone to increase informed choices at childbirth, in the context of the Covid-19 pandemic.	Not yet recruiting	Intervention	2020-07-29	<NULL>	<NULL>	4066	Communication intervention to improve informed choice at childbirth: a randomized controlled trial using digital technology in the context of the Covid-19 pandemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-28	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3g5f9f	<NULL>	1) Be a registered user at PiniOn app; 2) Identify theirselves as women; 3) Be aged between 18 and 49 years; 3) Being pregnant or having biological children of any age or intending to have biological children in the future.	Women without children and with no intention of becoming a mother in the future will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5fjcmr	Evaluation of Gynecological and Dermatological Acceptability of Health Products using the product at home.	Not yet recruiting	Observational	2020-07-30	<NULL>	<NULL>	4069	Evaluation of Gynecological and Dermatological Acceptability of Health Products under Normal Conditions of Use	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-08-24	Makelab Consultoria Eireli	Makelab Consultoria Eireli	https://ensaiosclinicos.gov.br/rg/RBR-5fjcmr	<NULL>	Women; Age: 18 to 65 years; Phototype: I to IV; Whole skin of the region; Occasional user of category products	"Skin marks in the experimental area that interfere in the evaluation of possible
reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Background of atopy; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; Discharges; Immunodeficiency patients; Kidney, heart or liver transplantation;
 Active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus,
atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study .; Any condition not mentioned above that, in the investigator&apos;s opinion, may
compromise the evaluation of the study.
Note: the participants included are instructed not to change their diet, routine
exercises and contraceptive method. Also, not to use products of the same category
of the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-5bxtgx	Electric current applied to women with painful menstrual cramps: A randomized clinical trial with economic evaluation.	Not yet recruiting	Intervention	2019-11-01	<NULL>	<NULL>	4074	Transcutaneous electrical nerve stimulation for primary dysmenorrhea: A randomized clinical trial with economic evaluation.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-15	Universidade Federal de São Carlos	São Paulo Research Foundation	https://ensaiosclinicos.gov.br/rg/RBR-5bxtgx	<NULL>	Nulligravid women over 18 years old; women with a regular menstrual cycle; and women with PD: with a report of pain equal to or greater than four points on the Numerical Rating Scale in the last three months.	Pregnant women or postpartum women; women with intrauterine device (IUD); women with lesions in the area where the electrodes will be placed; women with neurological or cardiac diseases; and women with diagnose gynecological disorders such as endometriosis, adenomyosis and uterine fibroids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-8g9897	Evaluation of new models of intraocular lenses for cataract surgery.	Not yet recruiting	Intervention	2020-08-03	<NULL>	<NULL>	4080	Evaluation of the efficacy and safety of new models of intraocular lenses for cataract surgery.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Associação Evangélica Beneficente de Minas Gerais	Hospital Público Prefeito Osvaldo Rezende Franco	https://ensaiosclinicos.gov.br/rg/RBR-8g9897	<NULL>	"Patients who had a clinically documented diagnosis of age-related cataract (cortical, nuclear, sub-capsular, or a combination) who was considered amenable to treatment by
cataract extraction using the intracapsular facectomy method. Adult patients 21 years of age or older. Patients eligible for primary intraocular lens implantation. Patients willing and able to perform clinical and complementary tests for follow-up for a minimum period of 1 year after cataract surgery. Patients who require intraocular lens implantation powers ranging from 10 to 30 diopters. Patients with visual potential of 20/40 or better in the eye indicated for intraocular lens implantation. Patients with corneal cylinders to correct less than 1 diopter."	Patients with the best corrected visual acuity less than or equal to 20/200 in the contralateral eye. Patients with any pathology of the anterior segment in which the procedure of intracapsular facectomy with primary IOL implantation is contraindicated (examples: keratoconus, corneal dystrophies or scars, anterior uveitis). Patients with corneal inflammation or edema, included and not limited to: keratitis, keratoconjunctivitis and keratouveitis. Patients with uncontrolled glaucoma or glaucoma under treatment. Patients with a history of retinal detachment. Patients with diabetic retinopathy (proliferative or non-proliferative). Patients with congenital, metabolic, traumatic or complicated cataracts. Patients with marked microphthalmia or aniridia. Patients who have had previous proposed eye surgery. Patients who have already received another IOL in the contralateral eye. Irregular corneal astigmatism. Amblyopia. Clinically significant changes in the retinal pigment epithelium / macula. Neovascularization of the iris, camerular and retinal angles. Severe recurrent inflammation of the anterior or posterior segment of unknown etiology. Optical atrophy. Patients with immunodeficiency (infectious, neoplastic or medicated). Patients on chronic use of systemic steroids or immunosuppressive drugs. Patients participating in another clinical trial simultaneously. Patients with strong dependence on intermediate vision, night vision or specific occupational requirements (examples: commercial pilots and professional drivers).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-75bsvk	Video modeling technique in dental care for autistic children	Not yet recruiting	Intervention	2020-08-04	<NULL>	<NULL>	4083	Efficacy of the video modeling technique as a facilitator of dental care in children with Autistic Spectrum Disorder: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-08	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-75bsvk	<NULL>	Children of both sexes; between 4 and 12 years old at the time of the study; diagnosis within the autism spectrum disorder, verbal and non-verbal, which meet the diagnostic criteria established by the American Psychiatric Association	Autistic children with other associated syndromes, such as Down syndrome, Rett syndrome, Tuberous sclerosis; Autistic children with hearing and visual impairments; Autistic children with associated intellectual disabilities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-97vkx4	Comparison of the effect of hyaluronic acid injection versus extracorporeal shockwave therapy on chronic plantar fasciitis: a randomized controlled trial	Not yet recruiting	Intervention	2020-07-22	<NULL>	<NULL>	4092	Comparison of the effect of hyaluronic acid injection versus extracorporeal shockwave therapy on chronic plantar fasciitis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Instituto Prevent Senior	Instituto Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-97vkx4	<NULL>	Healthy volunteers; chronic pain; plantar fasciitis; age over 18 years	Neuropathy; skin lesions; degenerative lesions; previous allergy to sodium hyaluronate; allergies to avian proteins; collagen disorders; rheumatoid arthritis; seronegative arthritis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-2fw8kg	Initial study of the effects of cannabidiol in patients with generalized anxiety compared to the effects of an anxiolytic (clonazepan)	Not yet recruiting	Intervention	2020-08-07	<NULL>	<NULL>	4100	Pilot study of the effects of Cannabidiol in patients with Generalized Anxiety Disorder compared to the effects of Clonazepan	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-08-21	Faculdade de Medicina de Ribeirão Preto - USP	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-2fw8kg	<NULL>	Diagnosis of Generalized Anxiety Disorder (from SCID-5-CV); both sexes, education above eight years; age between 18 and 60 years; total score greater than or equal to 20 on the Hamilton Rating Scale for Anxiety (HAMA); total score greater than or equal to the Global Clinical Impression - Severity scale (CGI-S); total score greater than or equal to 17 on the Hamilton Depression Rating Scale (HAMD17).	Presence of general medical condition; history of neurological disease (except headache); current or past diagnosis of psychoactive substance abuse or use in the past three months; psychotic conditions of any nature according to SCID-5_CV throughout life; other psychiatric diagnoses in addition to generalized anxiety disorder in the last 6 months (except for past remitted depression, social phobia and / or specific phobias); suicide risk (including suicide attempt in the last 1 year); history of previous drug treatment for generalized anxiety disorder; hx of allergy or idiosyncratic reactions to Cannabis sativa derivatives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-2k66ft	Randomized,  study to evaluate early prone position in patients with COVID-19	Not yet recruiting	Intervention	2020-08-10	<NULL>	<NULL>	4103	Randomized, open, controlled study to evaluate early prone position in awake patients on spontaneous ventilation with mild to moderate respiratory distress syndrome secondary to COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-20	Rodrigo S Biondi	Rodrigo S Biondi	https://ensaiosclinicos.gov.br/rg/RBR-2k66ft	<NULL>	Patients with COVID-19 confirmed by RT-PCR or strong suspicion, defined as both typical clinical picture and typical chest CT scan. Presence of bilateral infiltrate on chest tomography and one of the following two: Patient with SpO2 below 94% in room air or Need for O2 by nasal catheter above 4L per min to maintain SpO2 above 94%	"Denial of the patient or physician or assistant team to participate in the study. Evident signs of ventilatory fatigue (RF greater than 30irpm, PaCO2 greater than 45mmHg, with pH less than 7.35 and use of evident accessory musculature with indication of imminent intubation
# Need more than 5 EPAP and 5 IPAP in NIV. Hemodynamic instability (need for Noradrenaline above 0.3mcg per kg per min). Respiratory failure (IRPA) with estimated intubation in the next 6 hours. Cervical, sternotomy or facial surgery less than 15 days ago. Impossibility of collecting arterial blood gases. Evidence or strong suspicion of a cause of IRPA other than COVID pneumonia. Disorientation. Pregnant women with a pregnant abdomen. Have participated in the study previously. Exclusive palliative care. Any clinical impossibility of prone position such as instability or fracture of the spine, pelvis or femur; Massive hemoptysis in need of surgical intervention; Anterior thoracic drain with air leak; Presence of pacemaker installed less than 2 days ago"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-9y32yy	Acute and chronic cardiovascular and respiratory changes in COVID-19 hospitalized patients and the effect of physical rehabilitation supervised by telecommunication	Not yet recruiting	Intervention	2020-05-24	<NULL>	<NULL>	4104	Acute and chronic cardiorespiratory changes in COVID-19 hospitalized patients: role of endothelial function and cardiovascular health in clinical-functional outcomes and effect of physical telerehabilitation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Estadual Paulista - UNESP	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-9y32yy	<NULL>	At least 100 adult patients (aged over 18 years), of both sexes, diagnosed with COVID19 in molecular biology exam, admitted (intensive care unit or infirmary) to referral hospitals in the state of São Paulo will be evaluated. According to the phases of the study, and for inclusion, volunteers must: PHASE 1 (to assess endothelial function and functional capacity): present hemodynamic and respiratory stability; not having the need for emergency medical care; not to be at imminent risk of death. The inability to express consent to participate in the study will not be considered an exclusion criterion, however, in this case, the informed consent form must be signed by the legal guardian. PHASES 2 and 3: not being pregnant; not be lactating. Patients with decompensated cardiovascular and/or pulmonary disease, and/or pacemaker users, and/or who have absolute contraindications for physical exercise (acute myocardial infarction; unstabilized unstabilized angina; uncontrolled cardiac arrhythmias with repercussion will not be included) hemodynamic; symptomatic severe aortic stenosis; uncontrolled symptomatic heart failure; acute pulmonary embolism or pulmonary infarction; acute myocarditis or pericarditis; acute aortic dissection).	Exclusion criteria will include: important hemodynamic and/or electrocardiographic changes during the cardiopulmonary stress test; need for hospital readmission; failure to meet 60% of scheduled interventions. Even if exclusion occurs during the phases, these patients will still be followed up by telephone, up to 12 months, to assess out-of-hospital outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-4wzd8p	Treatment of Neck Metastases from Thyroid Cancer by Ultrasound Guided Ablation	Not yet recruiting	Intervention	2018-07-18	<NULL>	<NULL>	4105	"Ultrasound guided percutaneous thermal ablation
of cervical metastases from thyroid carcinoma"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Instituto do Câncer do Estado de São Paulo - ICESP	Fundação Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-4wzd8p	<NULL>	18 years of age or older; Patients with fine needle aspiration biopsy (FNAb)-proven metastatic cervical lymph nodes at levels I, II, III, IV, V, VI or VII from thyroid carcinoma (well differentiated, papillary - PTC or medullary) who underwent total thyroidectomy and subsequent radioiodine therapy, in case of PTC; Patients considered high surgical risk candidate or patients who are informed about the ablation therapy and prefers it instead surgery; Patients with metastatic cervical lymph nodes over 0.8 cm diameter and under 4.0 cm diameter; no more than 6 metachronous cervical nodal metastases; Cervical recurrences in previously lateral neck dissection patients for well differentiated papillary or medullary thyroid carcinoma over 0.8 cm diameter.	Age under 18 years; Uncorrectable coagulopathy; Inconclusive or benign cytologic specimens; Pregnancy or breast-feeding; Anaplastic or poor-differentiated thyroid carcinoma; Partial thyroidectomy; Cervical tumors not considered to surgery (invading vessels, nerves, larynx or trachea); Serious medical illness, including any of the following: uncontrolled angina, myocardial infarction, cerebrovascular event within 6 months prior to the baseline visit, uncontrolled congestive heart failure; Participation in other studies that could affect the primary endpoint	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-6ckggn	Adapted Functional Training and Pilates Method in Individuals with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2019-11-21	<NULL>	<NULL>	4106	The Impact of Adapted Functional Training and the Solo Pilates Method on Motor and Non-Motor Symptoms of Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6ckggn	<NULL>	Inclusion criteria are defined as, participants with a clinical diagnosis of PD following the UK brain bank criteria (HUGHES et al., 1992); both sexes; aged 50 years or over; with stable doses at; at least two weeks; no change in medication; without any functional training or solo pilates for at least three months.	Exclusion criteria were, participants who did not reach the MMSE cut-off point (considering educational level) (BERTOLUCCI et al., 1994); classified in stage 5 PD (HOEHN; YAHR, 1967); who performed practice of any physical exercises to avoid confusion bias in the intervention; who did not complete all stages of the study; were not present in 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:55
RBR-4vy54v	On-Line Collectives in Mental Health: Transdisciplinary Action for Groups Vulnerable to COVID-19	Not yet recruiting	Intervention	2020-08-11	<NULL>	<NULL>	4111	On-Line Collectives in Mental Health: Transdisciplinary Action for Groups Vulnerable to COVID-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	FAPERGS	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4vy54v	<NULL>	Elderly people aged 60 or over or health professionals between 20 and 59 years old; score greater than or equal to 7 on the Self-Reporting Questionnaire.	elderly and health professionals who do not have access to the internet; individuals with indicators of neurological pathologies or with psychiatric symptoms or with risk of suicide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-9qrsf8	Comparison of the Erector Spinae plane block in pulmonary surgeries in relation to Paravertebral block	Not yet recruiting	Intervention	2020-08-12	<NULL>	<NULL>	4114	Comparison of analgesia of Erector Spinae plane block in pulmonary surgeries in relation to Paravertebral block: a randomized multicenter study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - HCFMRP	IAMSPE - Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9qrsf8	<NULL>	Patients over 18 years of age undergoing unilateral pulmonary surgery under thoracotomy or thoracoscopy approach.	Patients who refuse participation. Severe puncture site infection or deformity. Coagulation disorder (INR greater than 1.4 or use of anticoagulant medications and platelet count less than 100,000 / mm3). Body mass index greater than 35kg / m2. Renal impairment (creatinine clearance less than 30 ml/min). Failure to operate the PCA system or to sign the informed consent form. Patients undergoing bilateral surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-57z7gz	Daily contractions induced by transcutaneous electrostimulation modify clinical and functional outcomes in critically ill patients	Not yet recruiting	Intervention	2020-08-12	<NULL>	<NULL>	4115	Daily contractions induced by transcutaneous electrostimulation modify clinical and functional outcomes in critically ill patients: clinical, randomized, double-blind, controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-15	Luciana Mara Meireles Aguiar Pereira	Luciana Mara Meireles Aguiar Pereira	https://ensaiosclinicos.gov.br/rg/RBR-57z7gz	<NULL>	Patients over 18 years old admitted to the intensive care unit; both genders, on mechanical ventilation; who walked at least 10 meters before hospitalization.	Neuromuscular diseases; lower limb amputation; pregnancy; body mass index above 40 kg / m2; presence of external fixator or metal implants in lower limbs; open ulcers or skin lesions; pacemaker; rhabdomyolysis or creatinophosphokinase dosage above 4000 ui; cardiorespiratory arrest; spinal cord injury, stroke or head trauma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6z82zb	Electrical Currents Associated With Carboxytherapy In Cellulite: Double-Blind Randomized Controlled Trials	Not yet recruiting	Intervention	2019-12-18	<NULL>	<NULL>	4118	Pain management associated with carboxytherapy application in patients with cellulite	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-10	Universidade Federal de São Carlos- UFSCar	Universidade Federal de São Carlos- UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-6z82zb	<NULL>	Women; aged between 18 and 49 years, with body mass indexes (BMIs)  in between 18.5 of 39.9 kg/m; menstruation cycle; with no prior experience with carboxythrapy and with the presence of Grade I or light and II or moderate cellulite in the gluteal region	Pregnant women; breastfeeding women; women with metabolic and autoimmune dysfunctions; women presenting dermatological lesions in the gluteal region; women who underwent surgical procedures in the gluteus; women with a history of epilepsy; presence of malignant or benign tumours; heart disease and/or use of a pacemaker; hypoesthesia or anaesthesia in the gluteal region; women with organ dysfunction who participate in CO2 metabolism and elimination; such as renal failure; diuretic use; chronic pain (over 3 months);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-52qtts	Stress Urinary Incontinence: Comparison between Pelvic Floor Muscle Training and Pilates Method.	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	4120	Effects of Pelvic Floor Muscle Training (TMAP) or Pilates Method in the treatment of stress urinary incontinence in women: Prospective, Randomized and Controlled Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-02	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-52qtts	<NULL>	Women who complain of SUI and answer questions 3 and / or 6 of the ICIQ-SF questionnaire positively, and women who do not have urinary incontinence and who answer question 3 of the ICIQ-SF negatively.	The exclusion criteria established were the presence of neuromuscular diseases, inability to contract MAP (Oxford Scale &lt;1), having already undergone physiotherapeutic treatment for SUI.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-5smtym	Obstructive sleep apnea and orthopedic maxillary expansion	Not yet recruiting	Intervention	2020-08-13	<NULL>	<NULL>	4123	Polysomnographic evaluation of adult patients with Obstructive Sleep Apnea (OSAS) undergoing Orthopedic Maxillary Expansion	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5smtym	<NULL>	adults, 21 to 65 years old, diagnosed with OSAS by polysomnography; intolerance to continuous positive airway pressure (CPAP); with maxillary atresia; Mallampati 3 or 4; without palatine or lingual tonsillar hypertrophy	Patients with missing more than one upper molar, patients with dentures or partial or total dental implants; who have periodontal disease with alveolar bone loss; caries or extensive coronary destruction in posterior upper teeth; who do not agree with the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-4pfygr	Clinical study to assess the safety and tolerability of administration, directly into a vein, of human umbilical cord and placental blood plasma (Plasmacord®) in patients with Severe acute respiratory syndrome resulting from Sars-Cov-2 infection (fever, cough headache, muscle aches and difficulty breathing)	Not yet recruiting	Intervention	2020-08-13	<NULL>	<NULL>	4124	Clinical study to evaluate the safety and tolerability of intravenous infusion of plasma from human umbilical cord and placental blood (Plasmacord®) in patients with Severe Acute Respiratory Syndrome resulting from Sars-Cov-2 infection	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2020-07-27	CRYOPRAXIS - CRIOBIOLOGIA LTDA	CRYOPRAXIS - CRIOBIOLOGIA LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4pfygr	<NULL>	Age over 18 years; both sexes; positive test for COVID-19; indication for transfer to the intensive care unit (ICU) by the responsible medical team; according to institutional criteria and protocols; absence of therapeutic alternative	Pregnant women; under 18 years old; no indication of transfer to the intensive care unit (ICU) by the responsible medical team; according to institutional criteria and protocols; existence of therapeutic alternative	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6cvc85	Online Parent Training Platform for complementary treatment of behavioral disorders in Attention Deficit Hyperactivity Disorder	Not yet recruiting	Intervention	2020-08-17	<NULL>	<NULL>	4131	Online Parent Training Platform for complementary treatment of Disruptive Behavior Disorders in Attention Deficit Hyperactivity Disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6cvc85	<NULL>	Families whose children have Attention Deficit/Hyperactivity Disorder and/or Oppositional Defiant Disorder; children must have externalizing symptoms such as hyperactivity and/or oppositional behavior; children who are between 6 and 12 years old; male gender	Families whose children have severe psychiatric comorbidities (i.e. psychosis, bipolar affective disorder, severe depression), genetic or neurological; whose intelligence is below the 5th percentile; feminine gender. Families whose primary caregivers have intelligence below the 5th percentile or have been diagnosed with serious psychiatric conditions (i.e. psychoses, bipolar affective disorder, severe depression); and families with severe social adversity in the home context (i.e. domestic violence, physical abuse, extreme poverty, hunger)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:56
RBR-6sc7tp	Stimulation in patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4155	Stimulation of the Pontino peduncle nucleus area in patients with Parkinson&apos;s disease evaluation of motor results focusing on gait changes falls balance and impact on quality of life	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Faculdade de Medicina da Univeridade de São Paulo	Faculdade de Medicina da Univeridade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6sc7tp	<NULL>	"Patients diagnosed with idiopathic PD according to Queen Square Brain Bank criteria 23.
The diagnosis will be given by a neurologist specializing in movement disorders.
Presence of moderate PD, at least 4 years from the onset of motor symptoms.
Persistent motor dysfunction for at least 1 month despite drug adjustment.
Patients with moderate to severe gait disturbances and refractory balance to drug treatment.
Thus, they should have: score 3 (moderate) or 4 (severe) in items 12 and 13 of part II of the MDS-UPDRS and score 3 (moderate) or 4 (severe) in items 9, 10, 11 and 12 of part III UPDRS being on medication (medication status ON).
Cognitive performance appropriate to preoperative care.
Understanding of the stimulation system and recognition of adverse events.
Willingness of the caregiver or family member, and the patient himself, to come in frequent returns to ensure the best brain stimulation parameters."	"Age under 18 years.
Parkinsonism Associated With Other Degenerative Diseases
Secondary Parkinsonism.
Prior surgical treatment of PD symptoms.
Patients without clinical conditions for the surgical procedure due to noncompensated systemic disease.
Behavioral disorders and hallucinations associated with dopamine drug use and without drug control.
Patients with less than two years of schooling or visually impaired who cannot perform properly on neuropsychological tests.
Depression.
Dementia associated with PD
Refusal to undergo neurosurgical procedure.
Refusal to accept the informed consent form."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-9243v7	Remote exercise program for older adults on the waiting for physical therapy after hospital discharge: a clinical trial with economic evaluation	Not yet recruiting	Intervention	2020-08-24	<NULL>	<NULL>	4157	Telerehabilitation exercise program to maintain the conditioning of older adults on the waiting list for physical therapy after hospital discharge: a pragmatic trial with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9243v7	<NULL>	Individuals who are 60 years or older who are discharged from hospital with physical therapy referral; able to walk independently or with a walking device or another person help; allowed to do weight bearing with the lower limbs; able to sit and stand from a chair; have a stable clinical condition; able to understand instructions and answer examiner commands during the tests; have a smartphone with internet access (of their own or of their companion/caregiver); have a companion/caregiver who will be present during exercises.	Individuals who present clinical complication that makes physical exercise prohibited; present neurological health conditions such as Parkinson Disease and Stroke; Mini Mental Examination scores lower than proposed by Bertolucci et al (2014); and inability to understand or complete the proposed tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-3yb4b9	Evaluation of genetic instability and cytotoxicity in professionals who work in surgical center of the veterinary hospital and are exposed to isoflurane anesthetic	Not yet recruiting	Observational	2018-01-25	<NULL>	<NULL>	4160	Evaluation of genetic instability and cytotoxicity in professionals who work in surgical center of the veterinary hospital and are exposed to isoflurane anesthetic	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)	Departamento de Anestesiologia	https://ensaiosclinicos.gov.br/rg/RBR-3yb4b9	<NULL>	Have at least one year of operation in the surgical center; surgery of small and large animals; animal husbandry; animal reproduction; sádios volunteers; both genders; age between 18 and 60 years	Carriers of malignant disease; infectious diseases: inflammatory; heavy use of alcohol; of &quot;illicit drugs&quot;; medicines; vitamin supplementation; work in some area with occupational exposure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:57
RBR-8jfg9v	Is cryotherapy applied with a protective towel in the elderly able to reduce skin temperature?	Not yet recruiting	Intervention	2020-08-26	<NULL>	<NULL>	4172	Is cryotherapy applied with a protective towel in the elderly capable of reaching the therapeutic temperature? Randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Programa de Pós Graduação em Ciencias da Reabilitação (PPGCR/UFSC)	Programa de Pós Graduação em Ciencias da Reabilitação (PPGCR/UFSC)	https://ensaiosclinicos.gov.br/rg/RBR-8jfg9v	<NULL>	The inclusion criteria for participating in the study are being 60 years old or older; both genders; resident of the city of Lages / SC; agreeing to participate in the study and abstaining from caffeine, tobacco, alcohol at least 1 hour before the intervention in the collection days.	Participants with skin lesions on the lower limbs will be excluded from the sample; changes in sensitivities related to cold; peripheral cardiovascular or vascular disease; musculoskeletal or neurological pathological conditions; smokers; diabetics; use of anti-inflammatory medication at least 2 hours before collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-72bg24	SARS-CoV-2 quick analysis in breath device	Not yet recruiting	Intervention	2020-08-27	<NULL>	<NULL>	4184	Technical feasibility studies for the diagnosis of Covid-19 by rapid non-invasive test	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-31	Instituto de Tecnologia do Paraná	Tera Brasil	https://ensaiosclinicos.gov.br/rg/RBR-72bg24	<NULL>	"Male and Female; Above 18 years old; 
The patient must accept and sign a form of willing and informed consent; The SARS CoV-2 carrier’s status shall be determined in a sample collected during the breath analyzed test (BAT); Outpatient cases; Symptomatic and asymptomatic."	Hospitalized patients; Subjects under general anesthesia; The incapacity of personally sign the consent form; The incapacity of blowing 5x in the test; BAT samples analyzed after 6h; Impossibility of obtaining a second sample; Symptomatic patients with over 5 days of symptoms for the first PCR sample or over 7 days for the repetition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-9bwxcx	Effect of red and infrared light for localized fat reduction in the abdomen	Not yet recruiting	Intervention	2019-04-15	<NULL>	<NULL>	4190	Effect of Photobiomodulation on reduction of abdominal measurements: Clinical, randomized, controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-10	Associação educacional Nove de Julho	Associação educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-9bwxcx	<NULL>	Men and women, 25-45 years old, with BMI between 18.5 kg / m2 to 29.9 kg / m2 will be included; with abdominal fat equal to or greater than 20mm and who agree with the participation in the research by signing the consent form.	The following people will be excluded from this survey: those participants who are undergoing aesthetic treatments to reduce waist circumference; those who have been previously submitted to abdominoplasty or liposuction surgeries; those who are on a diet, in order to reduce their measurements; those people who engage in a physical activity more than two times a week; those who are using or have taken drugs or food supplements in last 90 days, in order to reduce their measurements and their weight, which may affect their lipid metabolism, appetite or nutrients absorption; those who have been submitted previously to oophorectomy; those with signs and/or symptoms of climacteric at the menopause; pregnant or lactating women; those participants who are not regular in attending the sessions; those participants who present metabolic dysfunctions (diabetes and thyroid disorders), cardiovascular problems (hypertension, cardiac insufficiency, arrhythmia, thrombosis, pacemaker use), respiratory issues (asthma, chronic obstructive pulmonary disease), haematological disturbances (anaemia), renal, non-alcoholic fatty liver disease, dermatological or digestive disorders (gastritis, ulcers); those with a history of oncological pathology; those with cognitive deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-8yqbfr	Clinical performance of flowable resin composites with bioactive technology and resin-modified glass ionomer cement in noncarious cervical lesions of abfraction: a randomized control clinical trial	Not yet recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4191	Clinical performance of flowable resin composites with Giomer technology and resin-modified glass ionomer cement in abfraction lesions: a randomized control clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-10	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8yqbfr	<NULL>	Participants must be between 18 and 65 years of age; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep.	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:58
RBR-2xjprs	Pulmonary and movement description of patients who are treated by physiotherapy in a popular hospital	Not yet recruiting	Intervention	2020-08-31	<NULL>	<NULL>	4195	Functional kinetic pneumatic profile of patients seen at a physiotherapy clinic in a public hospital	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Hospital Universitário Regional dos Campos Gerais	Hospital Universitário Regional dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2xjprs	<NULL>	Men and women in the age group above and / or equal to 18 years of age with a diagnosis of COPD and who accept to participate in the present study by signing the Informed Consent Form (ICF).	Major physical changes that impact the execution of the tests; people who do not have medical authorization to perform physical activities; pneumonia or flu patients; coughing up blood; unstable angina; recent acute myocardial infarction or after coronary graft surgery; acute congestive heart failure; severe aortic stenosis; recent eye surgery; severe and uncontrolled hypertensive crisis (BP = 170/100 mmHG at rest) and tachycardia&gt; 120 bpm at rest; thoracic aortic aneurysm; acute pulmonary edema; uncontrolled arrhythmias such as atrial fibrillation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4dmnrr	Comparison of Bio Adhesive and Sutures in the Healing of the Palate after Graft Removal: randomized clinical trial	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4203	Comparison of Bio-Adhesive based on Cyanoacrylate and Conventional Sutures in Healing the Palate after Removing the Soft Tissue Graft: Randomized Clinical Trial	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2020-10-15	Centro de Ciências da Saúde (CCS)	Centro de Estudo e Pesquisa em implantes dentários (CEPID)	https://ensaiosclinicos.gov.br/rg/RBR-4dmnrr	<NULL>	"At least 18 years old- 70 years old;
Able to read and understand informed consent document;
Patients needing soft tissue graft with teeth that have miller class I or II recession, more equal 2mm, on the facial aspects;
Presence of periodontally healthy teeth at the recipient site equal or less than 25 percent plaque index;
Ability of the participants to maintain good oral hygiene;
Patient not pregnant or breastfeeding;
Not taking medications known to cause gingival enlargement;"	"Smokers/tobacco users;
Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing;
Patients that have severe gingival recession (Miller class III and IV) or less than 2 mm;
Presence of periodontal disease at the recipient site;
Poor oral hygiene;
Patient pregnant or breastfeeding;
Taking medications known to cause gingival enlargement."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2x2czx	Influence of Smoking on Genetic Mutation, Color Change and Sensitivity after home tooth whitening: a clinical study	Not yet recruiting	Observational	2020-09-01	<NULL>	<NULL>	4206	Influence of Smoking on Genotoxicity, Color Change and Sensitivity after home tooth whitening: controlled clinical trial	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-30	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2x2czx	<NULL>	Volunteers aged between 18 and 54 years; nonsmokers or smokers; volunteers with teeth of color A2 or darker; presence of the 6 upper anterior teeth	Presence of erosion, abrasion or friction in the anterior teeth; volunteers who have undergone previous whitening treatment; presence of periodontitis; presence of dental caries; any systemic diseases; restorations in the upper anterior teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-72wx7w	Transcranial electrostimulation protocol in cases of interstitial cystitis	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4207	Transcranial direct current electrical stimulation in the treatment of interstitial cystitis: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-72wx7w	<NULL>	Women with interstitial cystitis diagnosed by a doctor according to the ESSIC criteria (diagnosis of neuropathic pain confirmed using the DN4 scale); age between 18 and 65 years; preserved intellectual and physical capacity to carry out the research tests; pain above 4 on the numerical pain scale.	History of seizures or epileptic illness, metallic implants in the head or neck, pregnancy, conditions associated with other pelvic diseases previously diagnosed as primary dysmenorrhea, endometriosis, diagnosis of urinary tract infection and patients with indication for hospitalization, age over 65 and age below 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-4hsbjz	Behavior of parents and caregivers for the management and control of childhood Asthma: Clinical Trial with flipchart and Motivational Interview	Not yet recruiting	Intervention	2020-09-01	<NULL>	<NULL>	4208	Flipchart for Promoting the Self-Efficacy of parents and/or caregivers in the management and control of childhood Asthma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4hsbjz	<NULL>	Parents and/or caregivers of at least one child between 2 to 12 years old with an established medical diagnosis of asthma; prescribed inhalation treatment; with or without the use of a spacer; accompanied at the Primary Care Unit Health; have a cell phone or landline.	Parents and/or caregivers with apparent cognitive limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-2s94rb	Messages sent via WhatsApp to analyze adherence to protection measures in the pandemic	Not yet recruiting	Intervention	2020-09-02	<NULL>	<NULL>	4212	Effectiveness of messages via WhatsApp® in adhering to the use of masks and social distance	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2s94rb	<NULL>	Have a cell phone and have internet access to use the Whatsapp® application; literate and ability to understand the Portuguese language and without visual and / or cognitive impairment	Individuals who express a desire to no longer participate in the study will be excluded; those who have lost or changed their phone number; those who are hospitalized or dying and / or those who refuse to participate in the interview to assess outcomes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-68q84r	Acute effect of  electrical stimulation on Parkinsonian tremor inhibition	Not yet recruiting	Intervention	2020-09-03	<NULL>	<NULL>	4215	Acute effect of transcutaneous electrical stimulation on Parkinsonian tremor inhibition: A crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-68q84r	<NULL>	Volunteers with a proven diagnosis of Parkinson&apos;s Disease (PD); having hand tremors; having no associated diseases and accepting to participate in the research.	Volunteers with pacemakers; cardiac arrhythmias; pregnant women; metallic prosthesis in the area to be stimulated; uncontrolled hypertension; neoplasms; or any other contraindication for applying electric current.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:59
RBR-7qt9sp	The effect of Dance Therapy on the psychological aspects of patients with breast cancer	Not yet recruiting	Intervention	2020-09-09	<NULL>	<NULL>	4233	The effectiveness of a Dance Therapy protocol on the psychological aspects of patients undergoing adjuvant treatment for Breast Cancer: the body beyond the disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7qt9sp	<NULL>	Women; age group older than 18 years; clinical stage I to III of breast cancer; be in adjuvant treatment with hormone therapy; be resident in the cities of Florianópolis or São José; present a release from the oncologist responsible for the practice of physical exercise.	Present some orthopedic or neurological limitation that prevents the practice of systematic physical activity; perform combined practice of any physical exercises in order to avoid confusion bias in the face of the intervention; having practiced dance therapy or free dance in the last three months; not be present in at least 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-5ntdwg	Clinical Performance of regular resin composite with bioactive technology and resin-modified glass-ionomer in restorations of cervical lesions of Abfraction: a randomized controlled clinical trial	Not yet recruiting	Intervention	2020-09-11	<NULL>	<NULL>	4243	Clinical Perfomance of regular resin composite with S-PRG technology and resin-modified glass-ionomer in restorations of Cervical Lesions with predominance of Abfraction: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5ntdwg	<NULL>	Participants must be between 18 and 65 years of age; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep.	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-858zn7	Application of an educational action in pregnant adolescents on humanized delivery	Not yet recruiting	Intervention	2020-09-14	<NULL>	<NULL>	4245	Effects of an educational intervention for pregnant adolescents in the preparation for normal and humanized delivery	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2020-10-13	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-858zn7	<NULL>	"Age between 14 and 19 years
Gestational age from 16 weeks;
Attend prenatal care regularly;
Have a smartphone for intervention with a mobile app"	"hearing and visual impairment;
Do not attend prenatal consultations on the scheduled days;
Gestational age above 28 weeks;
Pregnant women with indication for cesarean section known since prenatal care;
Premature birth"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-25f7sc	Reduced tooth sensitivity using toothpastes with 8% arginine and low-power laser	Not yet recruiting	Intervention	2020-09-14	<NULL>	<NULL>	4247	Clinical evaluation on the effectiveness of reducing dental hypersensitivity in patients using 8% arginine-based dentifrices and a 320-360 nm laser. Parallel Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-20	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-25f7sc	<NULL>	"Individuals 18 to 75 years of age.
Both genders
Clinically healthy individuals
Availability to participate in the entire study
Sign the terms of free consent
Present hypersensitivity in non-adjacent teeth
Clear clinical presence of changes such as aberration, distress and erosion in anterior and / or molar teeth.
Response to the air jet stimulus for one second in the cervical region, as defined by the score 2 or 3 on the Schiff scale for sensitivity to the air stimulus.
Have good oral hygiene"	"Individuals with joys at the product being tested.
Individuals with clinical presence of pathologies recorded in the soft tissues.
Individuals undergoing chemotherapy and radiation therapy.
Individuals with gingivitis and / or periodontitis.
Individuals who will start taking anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory or analgesic drugs up to one month before the start of the study or who will start taking it during the study.
Individuals took antibiotics three months before the study.
Individuals participating in another study
Pregnant or breastfeeding women."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-52y5tq	Evaluation of the effectiveness of Adhesive Tissue in the skin and mucosa of Perineal Tears	Not yet recruiting	Intervention	2020-09-17	<NULL>	<NULL>	4252	Clinical trial on the use of surgical adhesive glue to repair first-degree perineal tears	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Thaís Trevisan Teixeira	Hospital Municipal Dr. Moysés Deutsch (M’Boi Mirim)	https://ensaiosclinicos.gov.br/rg/RBR-52y5tq	<NULL>	to have up to 6 centimetres of cervical dilation at the time the woman is invited to participate in the research; Do not use steroid substances; Do not present leucorrhoea or any signs of infection at the repair site; No diagnosis of diabetes mellitus; without history of allergy to surgical glue or formaldehyde; No difficulty in understanding the Portuguese language or in communication; Accept being submitted to perineal repair methods with skin adhesive or suture thread.	to have up to 6 centimetres of cervical dilation at the time the woman is invited to participate in the research; Do not use steroid substances; Do not present leucorrhoea or any signs of infection at the repair site; No diagnosis of diabetes mellitus; without history of allergy to surgical glue or formaldehyde; No difficulty in understanding the Portuguese language or in communication; Accept being submitted to perineal repair methods with skin adhesive or suture thread.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-287dkz	Phase III clinical trial of superiority, randomized, multicentre, blind, parallel, to evaluate the efficacy and safety of Lisador® (Cosmed) compared to Novalgina® 500mg (Sanofi-Medley) in the treatment of postoperative pain in abdominal-pelvic videolaparoscopy	Not yet recruiting	Intervention	2019-02-04	<NULL>	<NULL>	4257	Phase III clinical trial of superiority, randomized, multicentre, blind, parallel, to evaluate the efficacy and safety of Lisador® (Cosmed) compared to Novalgina® 500mg (Sanofi-Medley) in the treatment of postoperative pain in abdominal-pelvic videolaparoscopy	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2021-01-20	Brainfarma Indústria Química e Farmacêutica S.A.	Brainfarma Indústria Química e Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-287dkz	<NULL>	"-Sign the TCLE; 
-Men and women, aged 18 or over;
-To present pain evaluation by the pain intensity scale: from 3,0 to 7,9 cm;
- Having undergone elective surgery by abdominal-pelvic videolaparoscopy, not due to malignancy;
- Schedule to be discharged within 24 hours of the end of the surgical procedure;"	"• Presence of infection associated with the condition, except for appendectomy;
• Surgery with indication for treatment of confirmed or suspected malignancy;
• Laparoscopic surgery that required conversion to open surgery;
• Use of opioids in the last 8 hours of signing the informed consent form;
• Chronic use of painkillers regularly for other reasons;
• Use of corticosteroids;
• Chronic use of any non-steroidal anti-inflammatory;
• Use of immunosuppressive therapy;
• Participants with a vomiting condition present at the time of signing the informed consent form;
• Presence of decompensated diabetes mellitus;
• History of decompensated obstructive or restrictive respiratory disease;
• History of blood dyscrasia or chronic disease of any nature that contraindicates the participation of the participant at the discretion of the investigator;
• Inability to understand and perform pain assessments in the study;
• Hypersensitivity or contraindication for use of the studied medication components;
•	Morbid obesity;
• Pregnant women;
• Present one or more flu-like symptoms such as: fever, cough, dyspnoea, myalgia and fatigue, respiratory symptoms, gastrointestinal symptoms (such as diarrhea) within 14 days prior to the screening visit;
• Participation in another clinical study in less than 1 year."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-73gfct	Clinical trial to evaluated the efficacy and safety of  Maxsulid® (Cosmed) compared to Nisulid® (Aché) medicine in the treatment of postoperative pain of wisdom teeth extraction.	Not yet recruiting	Intervention	2019-02-12	<NULL>	<NULL>	4258	No inferiority Phase III clinical trial, randomized, multicentre, parallel and blind to evaluated the efficacy and safety of  Maxsulid® (Cosmed) compared to Nisulid® (Aché) medicine in the treatment of postoperative pain of third molar extraction.	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2019-06-30	Brainfarma Indústria Química e Farmacêutica S.A.	Brainfarma Indústria Química e Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-73gfct	<NULL>	Sign the Informed Consent approved by the Ethics Committee,age greater than or equal 18 years old, participants of both sexes, have a third molar removal dental surgery in the last few hours and have a pain assessment on the VAS scale at least 50 mm.	Have used anti-inflammatories or analgesics of any nature in the last 48 hours; Have a history of peptic ulcer or gastrointestinal bleeding; Illness of any nature that contraindicates participation in the study; Is not able to understand and perform the pain assessments present in the study; Hypersensitivity or contraindication known to the medications or components of the medications studied; Pregnant or lactating women; Professionals and their relatives who are directly involved in the process during this study; Participation in another study in less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-27xb3b	Effect of restriction pressure on perceptual, metabolic and neuromuscular responses	Not yet recruiting	Intervention	2020-09-20	<NULL>	<NULL>	4266	Analysis of perceptual, metabolic and neuromuscular responses in resistance exercises with different levels of blood flow restriction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-27xb3b	<NULL>	Resistance training practitioners; healthy; male gender; age between 18 and 30 years; osteomioarticular lesions free in lower limbs.	Use of anabolic steroids; use of food supplements with ergogenic potential; inability to perform the knee extension and jump exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:01
RBR-4yr9mt	Evaluation of the effects of oxytocin in patients with schizophrenia	Not yet recruiting	Intervention	2020-09-22	<NULL>	<NULL>	4272	Evaluation of the effects of oxytocin in patients with schizophrenia	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-12-01	Faculdade de Medicina de Ribeirão Preto	Flávia de Lima Osório	https://ensaiosclinicos.gov.br/rg/RBR-4yr9mt	<NULL>	"General: Men aged 18 to 50 years, literate, signing the Informed Consent Form.
For the clinical group, the participants must have a diagnosis of Refractory Schizophrenia, with a disease duration between 10 and 15 years, be on an outpatient treatment, using Clozapine exclusively and without psychiatric comorbidities.
For the control group, participants must have no current or previous psychiatric disorder and use any psychotropic drugs. For Phase 3 of the study, participants in the control group must be overweight (BMI  greater than 25kg / m2)."	"For clinical and control group: presence of clinical diseases of great impact on the functioning of the organism, such as degenerative, neurological diseases, cancers, hematological, pulmonary, renal, liver, cardiovascular diseases and / or use of psychoactive substances.
For Phase 3: participants using oral antidiabetics, lipid-lowering drugs, sibutramine, amphetamines, orlistat or other medications for the treatment of excess weight will also be excluded. Participants with schizophrenia who experience any change in their medication or therapeutic prescriptions during the period of participation in the study will be automatically excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-3yn9nz	Effects of functional electrical stimulation of the thigh in patients undergoing cardiac surgery	Not yet recruiting	Intervention	2018-01-15	<NULL>	<NULL>	4275	Effects of Functional Electrical Stimulation of quadriceps in patients undergoing coronary artery bypass grafting and valve replacement	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade de Santa Cruz do Sul	Universidade de Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3yn9nz	<NULL>	Patients in the postoperative period of valve replacement surgery or myocardial revascularization; Age range between 30 and 80 years; Patients of both sexes; Patients stable from the hemodynamic and neurological points of view; No elevated pulmonary vascular resistance; Signature of the Term of Free and Informed Consent (TCLE) by the legal guardian.	Present peripheral nervous injury; Present heart pacemaker; Present quadriceps area with altered sensitivity; Refractoriness to electrical stimulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:02
RBR-97nt6j	Multicenter Study of the Integrative and Complementary Practice of the Use of Ozone Gas in Outpatients with Covid-19	Not yet recruiting	Intervention	2020-09-24	<NULL>	<NULL>	4286	Estudo Multicentrico da prática Integrativa e complementar de Ozonioterapia em pacientes ambulatoriais com Covid- 19	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-09-25	Associação Brasileira de Ozonioterapia	Associação Brasileira de Ozonioterapia	https://ensaiosclinicos.gov.br/rg/RBR-97nt6j	<NULL>	"Man and women 
Age between 18 and 90 years;
Signature of the informed consent form (ICF).
COVID-19 positive PCR (Swab) exam"	"Pregnancy, especially in the beginning;
Individuals who continuously use immunosuppressants or have been transplanted for less than 6 months;
Individuals participating in other clinical studies.
Symptoms of severe acute respiratory syndrome (SARS) and / or comorbidities according to the regulations of the Ministry of Health (Guidelines for Diagnosis and Treatment for COVID-19, version 1 of April 6, 2020), with suspicion of COVID-19, with Covid RT-PCR -19"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-6nrnk9	Two techniques for osseous preservation after tooth extracton: a clinical study	Not yet recruiting	Intervention	2020-09-25	<NULL>	<NULL>	4294	Assessment of two different techniques for alveolar preservation and patient reports	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-31	Universidade Federal do Rio Grande do Sul	Universidad Científica del Sur	https://ensaiosclinicos.gov.br/rg/RBR-6nrnk9	<NULL>	Individuals with 18 years-old or older and periodontally healthy; less than 10 percent bleeding on probing without obvious periodontal pockets; present a non-molar tooth with extraction indicated; Type II or I sockets; Present a cone beam computed tomography (up to 1 month) of the region; No history of systemic diseases that contraindicate the surgical procedure, including the need for antibiotic prophylaxis; Do not use continuous use drugs including anti-inflammatory steroids and non-steroids; Present at least two tooth adjacent to the element that will be extracted; Not be pregnant or breastfeeding.	Not able to attend postoperative evaluations; Presenting symptoms of infection or hypersensitivity in the operated area; Smokers or ex-smokers (less than one year); Patients with fractures of the vestibular bone at the time of extraction with more than 50% loss of vestibular wal; Extractions with complications/accidents lasting more than 45 minutes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-5snp6g	The effect of the Application of Potassium Nitrate with the addition of Ozone on the Reduction of Sensitivity after Dental Whitening in the Office.	Not yet recruiting	Intervention	2020-09-28	<NULL>	<NULL>	4296	Evaluation of the Application of 5% Ozonized Potassium Nitrate in the Reduction of Sensitivity after Office Bleaching - Clinical, randomized and blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5snp6g	<NULL>	The study will include: patients of both sexes, aged between 18 and 35 years; with the presence of all vital anterior teeth, never bleached or restored; with periodontal health; no history of spontaneous dental pain; who do not use toothpaste with desensitizing properties and are willing to return to future evaluations during the research period.	The study will exclude: patients with missing anterior teeth, affected by caries lesions, with the presence of recession, with some type of restorative or prosthetic treatment or who use a fixed orthodontic appliance; with bruxism or visible enamel cracks; with a history of periodontal disease or active periodontal disease; with a history of dental hypersensitivity; with color change in the teeth due to fluorosis or tetracycline; who make use of many medications and pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-8j8wyz	Phase III of the research, unicentric, national, prospective, double-blinded, randomized study, intended to evaluate the superiority of the kenkobio device efficiency compared to the placebo device, as well as evaluate the safety on various treatment groups, on research participants diagnosed with low back pain or with mild or moderate cervical pain, as well as demonstrating improved blood circulation	Not yet recruiting	Intervention	2020-09-29	<NULL>	<NULL>	4300	Phase III of the research, unicentric, national, prospective, double-blinded, randomized study, intended to evaluate the superiority of the kenkobio device efficiency compared to the placebo device, as well as evaluate the safety on various treatment groups, on research participants diagnosed with low back pain or with mild or moderate cervical pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	kenko patto photon industria e comercio ltda	Allergisa Pesquisa Dermato-Cosmética Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8j8wyz	<NULL>	The research participants included on this research must satisfied the inclusion criteria: present capability of provide in written, in person, signed and dated the free and enlightened consent to participate on the research, in accordance with the Document of the Americas and to follow the guidelines and regulations applicable to the study procedures; present the ability to read, understand and complete the questionnaires applied to the study; be mentally empowered to provide your consent and meet all the study requirements; men and women aged between 18 and 65 years; presence of pain of mild to moderate intensity related to pain, in at least one type of pain according to a visual analog scale (VAS) of and considering the following intensity criterion: score 1 to 3 = mild pain; score 4 to 6 = moderate pain.	The research participants, that will be included on this research, may not have the following exclusion criteria: research participants which participated previously on any clinical research involving products under investigation within 30 days before randomization; history of non-adherence to previous studies; people who are directly involved in the study; use of opioids 07 days before the randomization visit; use of intra-articular steroids or hyaluronic acid injection or other immunosuppressive medication 3 (three) months before the randomization visit; current pregnancy or lactation during 3 months before the study begins; imminent need for primary surgical treatment; known history of gastrointestinal diseases, urological or current pelvic inflammatory disease, that may cause symptoms of pelvic pain, such as endometriosis; cervical and lumbar pain caused by neurological symptoms; history or suspicion of cancer, such as: Primary tumors (vertebra or spine), Metastatic vertebral tumors (mostly on  breast, lungs or prostate); significant systemic mental or chronic illness, that may interfere with the pain evaluation or the ability to complete the study; grade 3 obesity (BMI greater than or equal to 40 kg/m2); infectious diseases such as (eg, discitis, epidural abscess, osteomyelitis); patients with diseases such as herniated disc, osteoid osteoma; spondyloarthropathies, fibromyalgia, compression fracture, osteoarthritis, among other diseases of specific structural injuries; use of pacemaker, possibility of using defibrillator; undergoing hemodialysis sessions; use of magnetic mattresses and / or equipment that have the same or similar operating principle as the investigational product; presence of neoplastic disease with indication for systemic chemotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-9v7gj4	The impact of adapted functional training and pilates on the symptoms of individuals with parkinson&apos;s disease	Not yet recruiting	Intervention	2020-09-29	<NULL>	<NULL>	4301	The impact of adapted functional training and the solo pilates method on motor and non-motor symptoms of individuals with parkinson&apos;s disease	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2021-02-10	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9v7gj4	<NULL>	Inclusion criteria are defined as, participants with a clinical diagnosis of PD following the UK brain bank criteria (HUGHES et al., 1992); both sexes; aged 50 years or over; with stable doses at; at least two weeks; no change in medication; without any functional training for at least three months.	Exclusion criteria were, participants who did not reach the MMSE cut-off point (considering educational level) (BERTOLUCCI et al., 1994); classified in stage 5 PD (HOEHN; YAHR, 1967); who performed practice of any physical exercises to avoid confusion bias in the intervention; who did not complete all stages of the study; were not present in 75% of the prescribed classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:03
RBR-4qgpg5	Educational intervention for food consciouness in women	Not yet recruiting	Intervention	2020-09-29	<NULL>	<NULL>	4304	"Sensoriality as a marker of the relationship with food: education program
with sensory and cognitive exercises"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4qgpg5	<NULL>	The study population will consist of adult women (aged 20 to 59 years) with Body Mass Index between 18,5 and 34,9 kg/m², weight gain greater than 5% in the previous year and that refer desire to improve their relationship with food.	It will not be included pregnant or lactating women, smokers, diabetics, women using psychiatric drugs, nutritionists and women with a BMI of 35 kg/m² or greater (grade 2 obesity).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-6cmf4j	Effects of two exercise protocols on pain, functional mobility and quality of life in individuals with hip osteoarthritis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4310	Effects of combined versus aerobic exercise on pain, functional mobility and quality of life in individuals with hip osteoarthritis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-10	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6cmf4j	<NULL>	"individuals aged at least 30 years; both sexes; with clinical diagnosis of osteoarthritis of
hip uni or bilateral; sedentary in the last 6 months"	"individuals with hip and / or knee arthroplasty, whether total or partial;
rheumatoid arthritis, neurological, cardiovascular and / or pulmonary diseases that can compromise
execution of the exercise protocol. Discontinuation criteria: discontinuation of
individuals who did not attend two or more sessions and / or those who gave up
participate in the study during the intervention."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-93rx9q	Blood flow occlusion in patients with knee osteoarthritis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4311	Blood flow restriction with different load levels in patients with knee osteoarthritis: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-93rx9q	<NULL>	Individuals of both sexes will be included; 50 years old and over; diagnosed with bilateral or unilateral knee osteoarthritis (OA) according to American College of Rheumatology criteria; moderate tosevere (scores between 5 and 13 on the Lequesne Questionnaire); with a minimum score of 24 points in the Mini Mental State Examination and who sign the Informed Consent Form (ICF)	Individuals with a history of surgery or any invasive procedure of the affected knee(s) will be excluded; who have undergone a physical therapy or strengthening program for knee injuries in the past three months; planned events, such as knee replacement or travel, which may interfere with individuals&apos; participation during the study period; history of acute myocardial infarction and / or stroke; history of peripheral arterial disease and / or deep vein thrombosis; history of cancer that has generated limitations or restrictions to physical exercise; decompensated systemic blood pressure without medical supervision and changes in dose or type of anti-inflammatory or analgesic drugs in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-85vqk6	Strength and flexibility training for pain reduction and work performance improvement	Not yet recruiting	Intervention	2020-02-06	<NULL>	<NULL>	4312	Effects of an exercise protocol for work related musculoskeletal disorders in grape collectors  from the São Francisco Valley	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-85vqk6	<NULL>	Subjects of both sexes aged 18 to 50 years; physically independent; has not participated in structured exercise programs for at least 3 months; absence of clinical conditions or unstable disease that contraindicates the practice of supervised physical exercise during pre-participation screening; chronic shoulder pain with score higher or equal trhee points in the numeric pain scale (0-10); have a positive result in at least three shoulder pain-specific orthopedic tests, namely: Neer, Hawkins-Kennedy, Jobe, painful arch and external rotation resistance test; no history of shoulder trauma or surgery; not present musculoskeletal disorders that make it impossible to perform exercises; not having high blood pressure, cardiovascular disease, heart failure, myocardial infarction, cerebrovascular accident and / or diabetes; not being in gestational period; and being workers who perform activities with their hands over heads.	Performing any type of exercise for the upper limbs during the intervention period or engaging in another physical activity program; continuous use of drugs and / or ergogenic resources that positively or negatively interfere with performance; participants affected by limiting health conditions; and pregnancy during the intervention period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-4ypn69	PA GEL 0415: Open, randomized clinical trial of efficacy and safety of sequential use of a single dose of antimoniate intralesional meglumine and topical paromomycin gel compared to three intralesional applications of meglumine antimoniate in the treatment of cutaneous leishmaniasis	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4315	"Open, randomized clinical trial of efficacy and safety of sequential use of
single dose of intralesional meglumine antimoniate and topical paromomycin gel
compared to three intralesional applications of meglumine antimoniate in the
treatment of cutaneous leishmaniasis"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-02-01	Banco Nacional de Desenvolvimento Nacional	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4ypn69	<NULL>	"Age group bigger then 12 years.
Both sexes.
Presence of skin lesions exclusively of ulcerated type with parasitological confirmation by at least one of the positive tests: anatomo-pathological, imprint, culture, PCR.
Presence of a maximum of three lesions up to 3 cm in their largest diameter, in any location, except the face and ear.
Agreement to participate voluntarily and signing the informed consent form. In the case of participants aged between 12 and 17 years, in addition to the parent&apos;s or legal guardian&apos;s consent, the minor&apos;s consent form will also be required."	"Presence of mucosal involvement or presence of non-ulcerated lesion (papule, nodule, plaque, vegetative).
Pregnancy or lactation.
Systemic or topical use (in the lesion) of corticosteroids that cannot be suspended during the follow-up period in the study (between D1 and D180).
Use of any treatment indicated for leishmaniasis within 90 days prior to inclusion in this study.
5. HIV infection or other immunodebilitating disease, defined as follows
The. History of bone marrow transplantation less than 24 months ago or transplantation of solid organs at any interval, if using immunosuppressive therapy.
B.Carriers of autoimmune disease in specific treatment or in activity (eg lupus, rheumatoid arthritis).
c. Use of immunosuppressive or immunobiological drugs (with the exception of vaccines) in the 60 days prior to screening prior to screening. Drugs used in the treatment of autoimmune diseases (such as monoclonal antibodies, TNF alpha inhibitors, intracellular signaling blockers) are considered.
d. Patients who received antineoplastic therapy in the 3 months prior to screening.
and. Primary immunodeficiency patients.
QTc interval on electrocardiogram greater than 450 ms for men and 460 ms for women31.
Users of intravenous drugs or other chemical dependencies (including alcohol abuse.
History of hypersensitivity to any study drug.
Any condition that prevents follow-up with the frequency recommended by the study.
10. Secondary wound infection (in this case, wait for resolution with usual clinical treatment recommended in the service to reassess inclusion).
If any previous topical medication is used, the patient must stop the application and may be included when there is no residue present."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-5w9tx9	Effect of a board game on the knowledge of the elderly about HIV / AIDS prevention	Not yet recruiting	Intervention	2020-10-01	<NULL>	<NULL>	4316	Effectiveness of a board game on the knowledge of elderly people in a school context about HIV /Aids prevention	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-04-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5w9tx9	<NULL>	Be sixty years old or over; be regularly enrolled in schools that have the EJA modality in Health District IV and have at least six months of study at EJA.	Elderly people who are enrolled but are not attending classes during the data collection period provided for by this study; elderly people who have had cognitive impairment assessed using the 6-item cognitive decline test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:04
RBR-3djfww	Effects of the blood occlusion technique performed before sports performance tests and strength assessment on the lower limbs of college soccer players: experimental, controlled and randomized research	Not yet recruiting	Intervention	2020-10-02	<NULL>	<NULL>	4322	Effects of Ischemic Preconditioning  on the functional and neuromuscular performance of lower limbs in university soccer players: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-20	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3djfww	<NULL>	The study will be attended by men, university football players from the city of Natal / RN aged between 18 and 35 years old who regularly train and play football at least 3 times a week. The following will not be included: subjects with body mass index (BMI) less than 18.5 kg / m-2 and greater than 30 kg / m-2; with musculoskeletal injury in the lower limbs in a period of three months before the tests; with lower limb surgery within six months of testing; with uncontrolled metabolic diseases; with inflammatory rheumatological condition or severe cardiovascular and / or pulmonary disease that prevents them from carrying out the proposed evaluation and tests.	The exclusion criteria adopted were: missing a research data; at any time and for any reason expressing a desire to leave the study; present a health problem that prevents them from continuing to participate in the research; use drugs or any therapeutic resources to improve performance or practice unusual or strenuous physical activities during research period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-65s7m5	Physiotherapy in pregnant women with HIV through call center.	Not yet recruiting	Intervention	2020-10-06	<NULL>	<NULL>	4330	Obstetrics Physiotherapy through digital / teleconsultation: pregnant women living with HIV	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-02	Dominique Klazcko	Hospital Universitário Gaffrée e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-65s7m5	<NULL>	"Pregnant women; primiparous or secondary; age between 15 and 35 years; body mass index (BMI) between 18 and 35 kg / m2; gestational age at
from 16 weeks; single fetus; with no previous complaint of low back pain and urinary incontinence; who is undergoing prenatal care at HUGG; diagnosed with HIV + after the year 2013; to have a cell phone that can receive messages through the WhatsApp Web application
as well as videos and that you can have video call communication."	"Women with more than two pregnancies; at risk of miscarriage; uterine bleeding; current inflammation and / or urinary infection; cognitive deficit that
prevent understanding of the commands; use of illicit drugs; pre-existing pelvic surgery; hypertension; diabetics; showing symptoms of
candidiasis; or presenting another STI. Patients diagnosed with COVID-19 will be excluded from the study. Those who during the exercises have symptoms of cough, fever or shortness of breath should immediately stop the study due to symptomatic COVID-19."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-9x6fyj	Electrical Stimulation in Pain in Knee Osteoarthritis	Not yet recruiting	Intervention	2020-10-09	<NULL>	<NULL>	4338	Effects of Electrical Stimulation on Pain Reduction in Individuals with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	UFPE - Universidade Federal de Pernambuco	UFPE - Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9x6fyj	<NULL>	The sample will consist of individuals with clinically confirmed osteoarthritis; pain for at least two months and obtaining more than three points on the visual analog scale (VAS), during the evaluation period.	People unable to understand or perform the procedures; who have visual and / or hearing impairments; who have deformities / abnormalities that compromise the mechanics of the locomotor system; individuals participating in any ongoing physical activity program; individuals who hinder the therapeutic protocol for more than two consecutive absences; any surgical procedure in the lower limbs or planned for the next 6 months; musculoskeletal injuries or injuries in lower limbs; respiratory comorbidities; cardiovascular and neurological comorbidities; hypertension or hypotension at the time of collection; skin lesions; infection or tumor; fibromyalgia; systemic lupus erythematosus; alcohol abuse; cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-3cpthr	Development of a Brazilian Perinatal Bereavement Guideline	Not yet recruiting	Observational	2020-10-15	<NULL>	<NULL>	4340	The Brazilian Perinatal Bereavement Project. Development and evaluation of Supportive Guidelines for families experiencing stillbirth and neonatal death in public maternities wards in Ribeirão Preto: a quasi-experimental study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3cpthr	<NULL>	To live in one of the municipalities of the Ribeirão Preto region (XIII Regional Health Department, São Paulo State). Have experienced a stillbirth or a perinatal death during the estimated period. Have faced the death of her baby in the following circumstances: pregnancy that lasted more than 20 complete weeks; had a baby weighing at least 500g (stillbirth); had a baby that died no later than twenty-eight days after the birth (neonatal death).	Do not understand Portuguese and have severe mental health impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:05
RBR-9b6kvp	Effect of a Cloth Mask Physical Exercise session on Cardiovascular health, Feeling and Exercise Effort, Oxygen Quantity and Jumping Performance: Recommendation for Physical Mask Exercise during and after the COVID-19 global outbreak	Not yet recruiting	Intervention	2020-10-29	<NULL>	<NULL>	4353	Acute and Sub-acute Effect of the Use of Cloth Mask During Exercise on Cardiovascular Parameters, Psychophysiological Responses, Oxygen Saturation and Specific Performance: Recommendation for the practice of physical exercise with a mask during and after the global outbreak of COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-02	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9b6kvp	<NULL>	the athlete cannot have a recent history of injury and rehabilitation in the last 3 months; have respiratory diseases (e.g., asthma); the group with previous experience in aerobic training must train at least 30 minutes a day and 3 days a week; and the group not involved in a training program must not have carried out any form of systematic training for at least 6 months; age between 18 and 65 years;	Individuals who do not complete the assessments to be carried out or miss any of the exercise sessions will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-8x8g36	Effectiveness of a mouthwash and toothpaste containing PHTALOX in controlling symptoms of COVID-19 and flu	Not yet recruiting	Intervention	2020-10-29	<NULL>	<NULL>	4357	Efficacy of mouthwash and toothpaste containing PHTALOX in the clinical control of COVID-19 and Flu Syndrome: a randomized triple-blind clinical tria	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2020-11-01	Instituto Federal do Paraná	Instituto Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8x8g36	<NULL>	Adult individuals (&gt; 18 years old), of both sexes, from the city of Londrina with clinical suspicion of COVID-19, submitted to testing through RT-PCR at the Sabará-Londrina Emergency Care Unit (UPA), who have no contraindications to perform mouthwash / gargle and have access to the cell phone with communication application (WhatsApp).	Patients who do not present clinical conditions, during the research, to perform mouthwashes / gargles daily, who did not tolerate the use of the products, who are hospitalized for treatment of the disease or give up participating in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-8td9hs	Donepezil´s effects in patientes with long standing Tinnitus	Not yet recruiting	Intervention	2020-11-03	<NULL>	<NULL>	4360	Efficacy of Donepezil in patients with chronic Tinnitus	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2021-01-29	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8td9hs	<NULL>	Adults over 18 years old; with tinnitus one-sided or bilateral, for more than 6 months, caused by sensorineural hearing loss	Pregnant women, nursing mothers;known hypersensitivity to donepezil or piperidine derivatives; with external and or middle ear pathologies; other tympanograms than type A; with mixed or conductive hearing loss; using medications similar to donepezil (memantine, rivastigmine, galantamine) or less than 30 days of use; patients with supraventricular abnormalities of cardiac conduction or bradycardia, seizure, schizophrenia, ulcer, asthma or severe COPD; patients using carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampicin, ketoconazole and quinidine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-8x5mfq	Use of educational video to improve patient knowledge of safe care	Not yet recruiting	Intervention	2020-11-05	<NULL>	<NULL>	4366	Effectiveness of educational video on safe perioperative practices in patients undergoing Orthopedic Surgery: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8x5mfq	<NULL>	Patients undergoing elective orthopedic surgeries during the data collection period.	Patients with a nursing diagnosis, according to NANDA-International (NANDA-I) taxonomy, of Impaired Verbal Communication, defined as diminished, delayed or absent ability to receive, process, transmit and/or use a symbol system, will be excluded from this research. . This diagnosis has as main defining characteristics, partial or total visual deficit, disorientation in relation to people, time and space, difficulty in maintaining communication, using body and/or facial expressions, difficulty in understanding communication, difficulty in expressing thoughts verbally, difficulty speaking, forming words and/or phrases and inappropriate verbalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:06
RBR-6mkndk	Evaluation of the analgesic effect of Pregabalin for joint pain after Chikungunya.	Not yet recruiting	Intervention	2020-11-11	<NULL>	<NULL>	4371	Evaluation of the analgesic effect of Pregabalin for arthralgia after Chikungunya	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2021-02-01	Rodrigo Souza Rodrigues	Rodrigo Souza Rodrigues	https://ensaiosclinicos.gov.br/rg/RBR-6mkndk	<NULL>	35 participants will be included aged 18 to 100 years old; Both sexes; With chronic illness (more than 3 months); Individuals with arthralgia after chikungunya, previously diagnosed with sorology positive for CHIK; Individuals with pain upper than 4	Non-inclusion criteria patient with sorologies for CHIK with negative IGG and positive IGM; FR (rheumatoid factor) and FAN (antinuclear factor) positive in high values; Cognitive dysfunction (unable to understand the explanations); Psychiatric illness; Drug user; Pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-9j5pqs	Effect of Exercise on Pain and Disability Related to Spine Pain in the Elderly: A Randomized Clinical Trial	Not yet recruiting	Intervention	2020-11-18	<NULL>	<NULL>	4378	Efficacy of Exercise on pain and disability related to Chronic Low Back Pain in older people: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-9j5pqs	<NULL>	Older peoples men and women aged 60 or over; Complaining of nonspecific low back pain lasting at least 3 months; Disability rated 4/24 or more on the Roland and Morris Disability Questionnaire in the last six months and persistent back pain with 3/10 or more pain on the numerical pain scale in the last six months	Suspected or confirmed severe spinal pathology (fracture, metastatic, inflammatory or infectious diseases of the spine, cauda equina syndrome / generalized neurological disorder); Nerve root compromise; Spine surgery; Major surgeries scheduled during the treatment or follow-up period; Any of the contraindications for exercise listed on page 103 of the American College of Sports Medicine guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-6gmwrdh	Biopsies of pancreatic lesions for better diagnostic evaluation.	Not yet recruiting	Intervention	2020-11-26	<NULL>	<NULL>	4387	22G fine aspiration needle vs 22G fine biopsy needle in the diagnostic rate of solid pancreatic lesions with suspected malignancy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Faculdade de medicina da universidade de são paulo	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-6gmwrdh	<NULL>	"Patients with solid pancreatic lesion diagnosed through imaging method who attended the Endoscopy Department of Hospital das Clínicas of the School of Medicine of University of São Paulo (HC-FMUSP), Digestive endoscopy unit of Fortaleza General Hospital, or in the Digestive endoscopy unit of Hospital das Clínicas of Ribeirão Preto.
Age between 18 and 70 years; Signed the Informed Consent Form (ICF)"	No lesion identified through EUS; Duodenal papilla tumor; Unavailability of needles at the hospital at the time of the procedure; Presence of large vein or biliary stent in the puncture path; Contraindication for endoscopic puncture of the lesion; Current use of anticoagulants or known change in coagulation; Suspended or incomplete procedures; Participation in another clinical protocol that may affect the patient safety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-3ngffwr	Effect of the Manual Diaphragm Release Technique on Neurological Patients on Artificial Respiration	Not yet recruiting	Intervention	2020-11-27	<NULL>	<NULL>	4390	Effect of Manual Diaphragm Release Technique on Respiratory Biomechanics in Neurocritical patients on Mechanical Ventilation: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-25	Universidade de Pernambuco	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3ngffwr	<NULL>	Neurocritical patients from the Intensive Care Unit, University Hospital (HU) breathing by artificial airway (endotracheal tube) in PMV.	"Patients with acute decline in neurological status; elevation of refractory intracranial pressure; hemodynamic instability; hypotension (mean arterial pressure less than 60mmHg); pharmacological paralysis; mechanical ventilation with positive end-expiratory pressure (PEEP) bigger then 8cmH2O,
Inspired oxygen fraction (FiO2) greater than 60%; tetany; continuous renal replacement therapy; discomfort status; body mass index bigger then 30 kg / m2; previous chest surgery; chest instability; presence of chest tube; and any clinical changes for handling to perform the technique."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-9n5jbw	Aging of the immune system, Frailty and physical exercise in the elderly	Not yet recruiting	Intervention	2020-03-16	<NULL>	<NULL>	4393	Imunosenescence, Frailty and physical exercise in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina de Jundiaí	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-9n5jbw	<NULL>	Age equal to or greater than 60 years; understand the instructions and guidelines about the study and freely agree to participate.	The exclusion criteria will be: probable cognitive impairment identified using the 10-point cognitive screening instrument (10-CS) with a final score of 0 to 5 points; any contra-indication for the VIVIFRAIL program (acute heart attack (recent 3-6 months) or unstable angina; uncontrolled atrial or ventricular arrhythmias; aortic dissecting aneurysm; severe aortic stenosis; acute endocarditis / pericarditis; uncontrolled high blood pressure (higher than 180/100 mmHg);  acute thromboembolism; acute or severe heart failure; acute or severe respiratory failure; uncontrolled postural hypotension; uncontrolled acute decompensated diabetes mellitus or low blood sugar; a recent fracture in the last month (strength training); any other circumstance the doctors believes prevents doing physical activity, life-expectancy less than 12 months, permanent or temporary inability to walk; localized loss of strength and aphasia due to severe stroke; severe impairment of motor skills, speech or affectivity associated with Parkinson&apos;s disease in an advanced or unstable stage; severe hearing or vision deficits making communication very difficult; older adults who have cancer and autoimmune diseases in activity and follow-up; elderly people with cancer diagnosed in the last 3 years; inability to perform the Short Physical Performance Battery (SPPB) (score of zero); any limb amputation. Also, older patients who have performed physical activity or physical therapy in the 6 months preceding the start of the intervention will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-422x64	The effects of Muscle Stimulation of the whole body on the activities of walking, exercising and the risk of falling in elderly people who do not exercise	Not yet recruiting	Intervention	2020-04-08	<NULL>	<NULL>	4397	Effectiveness of Whole Body Electromyostimulation on function, muscle mass, strength, social participation, and falls-efficacy in older people: A randomized trial protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal de Juiz de Fora	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-422x64	<NULL>	Sedentary volunteers; both genders; elderly subjects with age from 60 to 80 years	Elderly that to present cognitive alterations detectable by the Mini Mental State Examination (BERTOLUCCI et al., 1994); that had participation in structured physical activity at last year; uncontrolled cardiac illness and/or metabolic disease; known history of cerebrovascular disease or sequelae neurological; active neoplasia during the previous five years;  surgical fractures or osteosynthesis in the last six months; severe visual and hearing difficulties; other pathological or orthopedic conditions that limits physical training or assessment outcomes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-5w2sqt	Effects of strength exercises with elastic bands and tubes on the difficulty of movements, quality of life, sleep, memory, depressive symptoms, balance and risk of falls of patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2020-03-25	<NULL>	<NULL>	4399	Evaluation of the effects of a power strength training program with elastic bands and tubes on cognition, functionality, quality of life, balance, physical fitness, muscle quality, balance, sleep and the risk of falls of Parkinson&apos;s disease patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-13	Faculdade de Medicina da  Universidade Federal do Ceará	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5w2sqt	<NULL>	Diagnosis of Parkinson’s disease according to the UK PD Brain Bank Diagnostic Criteria; Stages of 1 to 3 according to the modified Hoehn &amp; Yarh  scale; Stable antiparkinsonian medication regime for at least 4 weeks before the intervention; Literate; Independent in basic daily living activities according to SE higher or equal to 80%; Age of 40 years or more; Be a resident of Fortaleza.	"BMI greater than 40 and less than 20; Diagnosis of Chron&apos;s Disease and Ulcerative Colitis; Diagnosis of Multiple Sclerosis, ADEM, Parkinsonism plus, cerebrovascular disease with motor sequelae, Guilliam-Barre; Dementia syndrome of any etiology according to MSD-V; Schizophrenia with hospitalization or psychotic episode or suicidal ideation in the last 6 months; Bipolar affective disorder with hospitalization or episode of mania or episode of hypomania or episode of depression in the last 6 months; Depression with hospitalization or suicidal ideation or psychotic episode in the last 6 months; Myocardial infarction with or without ST elevation in the last 12 months; Myocardial revascularization surgery or percutaneous anglioplasty in the last 12 months; Uncontrolled arrhythmia; Severe or oxygen dependent COPD; Cardiac insufficiency with reduced functional class III or IV; Resting Blood Pressure greater than or equal to 160 x 100 mmHg;  Implantable cardioversion defibrillator (ICD);  Severe chronic kidney disease (Creatinine clearance less than 30ml/min); Proliferative retinopathy secondary to diabetes; Peripheral neuropathy with motor impairment;
Moderate to severe hearing impairment (inability to maintain a dialogue or need for lip reading); Moderate to severe visual impairment (minimum visual acuity 20/70 - Snellen); Cancer in activity or in treatment; History of conventional surgery or DBS for Parkinson&apos;s disease; Alcohol consumption greater than 14 drinks per week; Live with people who participate in the same study; Thromboembolism without anticoagulation regimen; Significant weight loss (10% of usual weight) in the last 6 months; Lack of family support to participate in the study; Bariatric surgery history; Exercise at moderate intensity for at least 3 x week; Glycated hemoglobin higher than 12."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-8vyvnmb	Safety use of Liraglutide in patients with Covid19 pneumonia	Not yet recruiting	Intervention	2020-12-09	<NULL>	<NULL>	4407	Use of Liraglutide to treat Covid19 pneumonia: A Phase II open-label, single center safety study with biomarker profiling	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2020-12-15	Universidade Federal de São Paulo - Disciplina de Pneumologia	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-8vyvnmb	<NULL>	Aged over 18 years old; Covid19 pneumonia admitted to hospital less than forty-eight hours including those within a critical care setting	Anticipated eligibility for extracorporeal membrane oxigenation support in subsequent 72h; life expectancy less than 48h estimated by one or members of the clinical team; impaired liver function, defined as alanine aminotransferase more than 3 times the upper limit of normal; impaired renal function, defined as an estimated glomerular filtration rate less than 30 mL/min/1.73m2; active pancreatitis; known allergy to liraglutide; pregnancy or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-4gq6khr	Effects of Photodynamic Therapy as aid on non-surgical treatment of Aggressive Periodontitis	Not yet recruiting	Intervention	2020-12-10	<NULL>	<NULL>	4409	Effects of Photodynamic Therapy as aid on non-surgical treatment of Aggressive Periodontitis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-12-16	Universidade Federal do Rio Grande do Norte	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4gq6khr	<NULL>	Individuals between 18 and 40 years old with a clinical diagnosis of Aggressive periodontitis, according to the American Academy of Periodontics (1999) or Periodontitid satages III or IV grade C; Presence of at least 8 teeth with PS &gt; 5 mm and CIN ? 5 mm, 2 teeth per quadrant; Agree to participate in the survey by signing the informed consent form	Pregnant and lactating women; Carriers of systemic diseases that compromise the immune system; Unable to answer the questionnaires or perform the tests or treatment; Allergic to Amoxicillin, Metronidazole, Chlorhexidine or Photosensitizer;Those who underwent periodontal therapy less than 6 months ago.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-2pcycpx	Sleep Promotion for patients undergoing Heart Disease Treatment: randomized clinical trial	Not yet recruiting	Intervention	2020-12-15	<NULL>	<NULL>	4419	Sleep Promotion for patients undergoing Percutaneous Intervention for the treatment of Heart Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-14	Universidade de São Paulo	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2pcycpx	<NULL>	Age over 18 years, communication and comprehension skills preserved.	Report of severe sleep disorder requiring daily treatment before hospitalization, such as sleep apnea, narcolepsy and chronic insomnia; presence of serious complication (aortic dissection, bleeding or stroke after the procedure) related to the treatment; presence of delirium as medical record evaluation; severe hearing and visual loss; history of neurological disease or diagnosed psychiatric disorders; admission to the Intensive Care Unit between 9:00 pm to 6:00 am after the percutaneous intervention procedure; treatment with mechanical ventilation; need for sedation during stay in the ICU, who are not fluent in the Portuguese language.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-9zj2w7	Potential of an experiment to promote walk in people with Myochardial Infarction or Angina	Not yet recruiting	Intervention	2019-10-03	<NULL>	<NULL>	4421	Efficacy of a theory-based intervention to promote walking in people with Coronary Artery Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Estadual de Campinas	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-9zj2w7	<NULL>	Will be included people aged 18 to 85 years, diagnosed with coronary artery disease in outpatient follow-up at the service; able to establish effective communication, demonstrating self and allopsychic orientation (Pfeiffer, 1975); with medical clearance to perform physical activity; with Cardiorespiratory Fitness measured at the time of interview through the Brazilian version of the Veterans Specific Questionnaire (VSAQ) with a value greater than or equal to six Metabolic Task Equivalents (6 MET) (VSAQ - Domingues et al., 2011) or Cardiopulmonary Test results of Effort with cardiorespiratory fitness outcome (measured or estimated) greater than or equal to six Metabolic Task Equivalents (6 MET) performed up to twelve months prior to the time of the interview; no systolic dysfunction, evidenced by Ejection Fraction above 40%, obtained by Teicholz or Simpson methods; from the Echocardiogram performed up to twelve (12) before the moment of the interview; and with a positive intention (greater than or equal to 4) to perform the walking behavior.	Participants will be excluded if they present other clinical conditions that make it impossible to carry out regular physical activity, such as neurological, vascular, orthopedic or other motor problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-8k66dh9	Influence of sexuality on mental health, family well-being, fragility and quality of life in the elderly	Not yet recruiting	Intervention	2020-12-16	<NULL>	<NULL>	4428	Educational interventions on sexuality and its effects on mental health, family functionality, fragility and quality of life of the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP/USP)	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-8k66dh9	<NULL>	Elderly aged over 60 years; male and female; married; in stable union; or with fixed partnership; and who are in satisfactory cognitive conditions assessed by the adapted version of the Cognitive Assessment Instrument	Elderly virgins or with cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:11
RBR-3www35z	Clinical Evaluation of the Truenat Point-of-care Tuberculosis Diagnostic Test	Not yet recruiting	Observational	2020-11-25	<NULL>	<NULL>	4432	Prospective, Multicentre Trial to Assess the Diagnostic Accuracy of the Truenat Assays at Intended Settings of Use	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Departamento de Ciência e Tecnologia - DECIT. Secretaria de Ciência, Tecnologia e Insumos Estratégicos – SCTIE, Ministério da Saúde-MS (SCTIE/MS)	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3www35z	<NULL>	Age 18 years or above; Clinical suspicion of pulmonary TB (including cough for at least 2 week and at least 1 other symptom typical of TB); Willingness to provide 3-4 sputum specimens at enrolment; Willingness to have a trial follow-up visit approximately 2 months after enrolment; Provision of informed consent.	"Case Detection Group:Receipt of any dose of TB treatment within 60 days prior to enrolment (even if within last two days only).
Drug Resistant TB Group: Receipt of any dose of MDR-TB treatment within 60 days prior to enrolment (even if within last two days only)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:11
RBR-3jpsv2	Evaluantion of a new rapid diagnostic test to indetify patients with resistance for tuberculosis´ drugs in Brazil	Not yet recruiting	Observational	2020-10-04	<NULL>	<NULL>	4433	Line Probe Assay performance validation as a rapid diagnostic test for resistant tuberculosis in reference centers in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Programa Nacional de Controle da Tuberculose CGPNCT / DEVIT Secretaria de Vigilância em Saúde/Ministério da Saúde	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3jpsv2	<NULL>	Clinical sample from patients with probable drug-resistant pulmonary tuberculosis (TB) according to Brazilian Ministry of Health Standards; Xpert MTB/RIF test positive to sputum sample submitted to LPA-1 test and routine diagnostic procedures (culture and antimicrobial susceptibility test in liquid medium); Sample from patient who has not received treatment regimen for TB sensitive drug or TB-DR/MDR for more than 7 days of the past 30 days; Sample from subject with HIV serological test (positive or negative; if the last documented negative HIV test was performed more than three months before the screening visit, the current serological status should be assessed); Sample from subject aged 18 years or older; Samples from subject with a Karnofsky score of 60 or greater at screening; Subject able to provide their consent by signing in the Informed Consent Form (ICF)	Samples from patients unwilling to take an HIV test if there is no documented HIV test result within three month; Samples from patients deprived of their liberty; Samples from patients whose Information about whether or not to start anti-TB treatment is not present in the medical records / forms of the participating Health Units or in the notification form; Lung samples with a positive result by Xpert MTB / RIF, in which culture or TS were not performed; Samples from patients with inconclusive results on the LPA1 and /or LPA2 tests; Samples from patients with Mycobacterium tuberculosis (MBT) isolates that do not grow or contaminate in the TS and those identified as non-tuberculous mycobacteria (NTM)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:11
RBR-9j7qqr	Dressing with product derived from snake venom to treat wounds in the legs	Not yet recruiting	Intervention	2015-06-29	<NULL>	<NULL>	4439	Fibrin sealant derived from snake venom for the treatment of venous ulcers: non controlled phase I / II to evaluate the safety, efficacy and confirm the lowest dose clinical trial - study selante II	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina de Botucatu - Unesp	Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-9j7qqr	<NULL>	Sign the term of free and informed consent; patients 18 years of age or older, of both sexes; chronic venous disease with chronic venous ulcers evidenced by one or more of the following signs: hyperpigmentation of the distal third of the lower limb, stasis eczema,  lipodermatosclerosis, varicose veins; to have at least one ulcer whose time evolution is minimum of 6 weeks and a maximum of 5 years; display the sum of the areas of the ulcers of both members between 5 and 60 square centimeters; at least one ulcer whose major area is above 5 square centimeters; do not use the following drugs in the last two weeks prior to screening: venotonics,  pentoxifylline, fibrinolytic drugs; Available to attend once a week for treatment.	"Leg ulcers of other etiologies ( causes hematological , neoplastic , infectious , among others) ; use of anticoagulants ; infected ulcers , or associated with erysipelas , cellulitis or lymphangitis; ulcer with critical colonization , ie ,large amount of exudate and / or foul and / or yellowish staining of the wound bed and / or green and / or red opaque odor and / or friable granulation tissue ; necrosis in the ulcer bed ; devitalized background with ulcer covering all your bed; venous ulcers associated with peripheral arterial disease that is characterized when the systolic ankle-brachial index is less than 0.9 and / or absence of distal pulses; being unable or does not wish to remain with compressive treatment of lower limb for seven days; to have a history of allergy to treatment with Unna boot; to have a history of allergy to treatment with essential fatty acid; known or suspected pregnancy;
values coagulation outside the normal range ( Activated partial thromboplastin time more than 1.25 and time and prothrombin activity less than 70% or more than 100%); women of childbearing potential not using contraception."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:12
RBR-8jp3db	Effects of Hypopressive Abdominal Gymnastics on the respiratory and nervous systems	Not yet recruiting	Intervention	2020-07-09	<NULL>	<NULL>	4451	Effects of Hypopressive Abdominal Gymnastics on lung function, respiratory muscle strength and autonomic nervous system	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-03	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8jp3db	<NULL>	women; nulliparous; healthy; aged 20-30 years,UFTM students; residents in Uberaba; BMI between 18.5 and 24.9.	history of abdominal and / or pelvic surgery;pregnancy or suspected pregnancy,high blood pressure, neurological diseases, diabetes mellitus, smoking, respiratory diseases;heart disease; use of intrauterine device (IUD) for less than 90 days; BMI equal to or greater than 25	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-8j3tzw	What is the effect of using the Tablet active and passive on child development?	Not yet recruiting	Intervention	2020-07-30	<NULL>	<NULL>	4452	The Influence of Interactive Media on Child Development in Children from 24 to 36 Months of Age	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-8j3tzw	<NULL>	Healthy children; Age 24 to 36 months; Regularly enrolled in the Municipal Children&apos;s Education Centers (CMEIS); Limited experiences in the use of interactive media; Participation in research authorized and consented by parents or guardians.	Children with neurological disorders that affect cognitive, linguistic and motor aspects; Autism; Moderate to severe hearing loss; mental or psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:13
RBR-5wvg53s	Benzbromarone medication treatment to improve Respiratory Health and Quality of Life for patients with Cystic Fibrosis	Not yet recruiting	Intervention	2021-01-05	<NULL>	<NULL>	4460	Benzbromarone for the treatment of Cystic Fibrosis	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2021-05-01	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	https://ensaiosclinicos.gov.br/rg/RBR-5wvg53s	<NULL>	Confirmed diagnosis of cystic fibrosis based on the following criteria: Positive sweat chloride 60 mEq liter; A genotype with two pathogenic CF mutations identified; FEV1 with values between 40% and 90% of that predicted in spirometry; Female patients who deny sexarche	"Beginning of any new therapy, for example, ibuprofen, Pulmozyme, hypertonic saline, azithromycin, TOBI, Cayston within four weeks before the start of the study; Episode of pulmonary exacerbation in the period of four weeks before the start of the study; Significant hemoptysis in the period of four weeks prior to the start of the study, 5 mL of blood in a coughing episode or 30 mL of blood in a 24 hour period; Abnormal liver function, TGO and TGP at levels three times above the reference values;
Abnormal renal function, glomerular filtration rate, GFR, below 60mL  min and 1.73m2 according to the calculation estimated by the Schwartz formula; Use of an experimental drug within four weeks before the start of the study; Use of intravenous or oral steroids within four weeks before the start of the study; Patients submitted to the list of lung transplant and or transplanted."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-10j9wjy5	Online mindfulness-based intervention for women with post-mastectomy chronic pain	Not yet recruiting	Intervention	2021-01-06	<NULL>	<NULL>	4464	Effects of an online mindfulness intervention for women with chronic post-mastectomy pain: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-11	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-10j9wjy5	<NULL>	Mastectomized women who have stopped treatments for at least 6 months; over 18 years; complaints of pain related to the surgical procedure for at least 6 months after surgery, measured with a score greater than or equal to three on a pain scale from 0 to 10; who have access to a computer, tablet or smartphone; who have access to the internet; availability to dedicate 2 hours a week for 8 weeks to participate in the intervention group.	Women with breast cancer recurrence, metastasis or any other type of cancer; severe psychiatric disorder and / or risk of suicide, or any type of dementia (self-report); current practice or in the last 6 months that includes contemplative states (yoga, meditation, mindfulness); other severe medical conditions related to the musculoskeletal or rheumatological system that are related to chronic pain conditions (example: fibromyalgia, osteoporosis, gout, bursitis, rheumatoid fever, rheumatoid arthritis, systemic lupus erythematosus and scleroderma, among others); who are unable to commit to the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-8r9hy8f	A Phase 2 clinical trial of Inhaled Unfractionated Heparin (UFH) for the tretatment of Hospitalised Patients with COVID-19	Not yet recruiting	Intervention	2021-01-06	<NULL>	<NULL>	4465	A Phase 2 clinical trial of Inhaled Unfractionated Heparin (UFH) for the tretatment of Hospitalised Patients with COVID-19	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2021-01-15	Galeno Desenvolvimento de Pesquisas Clínicas Ltda	Galeno Desenvolvimento de Pesquisas Clínicas Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8r9hy8f	<NULL>	Patients hospitalized with COVID-19 who do not require immediate mechanical ventilation (points 3-5 on the ordinal scale). Age from 18 to 80 years. Able to understand the nature and purpose of the study, including risks and adverse effects and with the intention of cooperating with the researcher and acting in accordance with the requirements of the entire trial, which is confirmed by signing the Term Informed Consent Form, prior to any study procedure. Women of childbearing potential should use a safe and effective method of contraception throughout the study. If the participant chooses to abstain from sex or practice any type of relationship that does not pose a risk of pregnancy, the use of contraception is not mandatory.	The participant is known to be hypersensitive to the studied drug (heparin) or to chemically related compounds. History of serious adverse reactions or hypersensitivity to any drug. The participant has any condition that prevents him from participating in the study due to the investigator&apos;s judgment. A participant shows a positive result for beta-HCG test and/or urine test for pregnancy; delivery or abortion in the 12 weeks prior to the scheduled vaccine administration date. Present COPD.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:14
RBR-499b2dy	Evaluation of the use of cognitive demand associated motor exercises in a cardiac rehabilitation program in the cognition of the elderly who have undergone prosthesis placement to unblock arteries	Not yet recruiting	Intervention	2021-01-12	<NULL>	<NULL>	4469	"Evaluation of the use of the Dual Task in a training program
Cardiac Rehabilitation in the Cognition of Elderly Patients
Percutaneous Coronary Intervention a Clinical Trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Instituto Nacional de Cardiologia	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-499b2dy	<NULL>	Elderly patients with heart disease; undergoing percutaneous coronary intervention in the last six months; both sexes	Elderly people who practice regular physical exercises for at least three months in the period prior to the study; osteomioarticular limitation that prevents the practice of exercises; diagnosis of neurodegenerative disease; history of stroke with or without sequelae; colorblind; who have a cutoff point less than or equal to 24 on the Mini Mental State Examination; undergoing open heart surgery in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-6ptj3fp	Effects of simultaneous exercise in the elderly	Not yet recruiting	Intervention	2021-01-12	<NULL>	<NULL>	4470	Effects of dual task in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade Maurício de Nassau	Faculdade Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-6ptj3fp	<NULL>	Volunteers of both sexes; aged 60 or over; non-obese (BMI bigger then30 Kg / cm2); sedentary or irregularly active according to the International Physical Questionnaire (PARDIDI et al. 1997); with independent gait and without physical, visual or auditory deficits that make it impossible to assess and / or apply the protocols; without cognitive deficit, indicated by a score equal to or greater than 22 points in the Leganés Cognitive Test (ZUNZUNEGUI et al., 2000).	Volunteers who have a phobia of water; acute infections; with the presence of phlogistic signs; fever; deep vein thrombosis; unstable cardiovascular diseases; urinary or fecal incontinence; epilepsy; tympanic perforations; in addition to epithelial disorders such as wounds; polite; dermatitis and / or fungi that can contaminate the pool and / or therapist.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-7rgqkhf	Analysis and validation of leven67 emergency respirator	Not yet recruiting	Observational	2021-01-15	<NULL>	<NULL>	4475	Analysis and validation of light mechanical emergency ventilation equipment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-17	ASSOCIAÇÃO BENEFICENTE DE CAMPO GRANDE - Santa Casa de Campo Grande	ASSOCIAÇÃO BENEFICENTE DE CAMPO GRANDE - Santa Casa de Campo Grande	https://ensaiosclinicos.gov.br/rg/RBR-7rgqkhf	<NULL>	Adult patients aged 18 to 80 years; both sexes; adult patients with COVID-19; submitted to tracheal intubation; who await the availability of a conventional ventilator and / or a place in an ICU or Surgical Center bed; in need of tracheal intubation to protect the airways (such as traumatic brain injury); decompensated heart failure; severe pneumonia; without surgery for the next 6 (six) hours	patients under 18 and over 80; indigenous, patients with high doses of vasoactive drugs and hemodynamic instability; polytrauma patients with surgery expected in less than 6 hours; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-9p3kmn8	Effectiveness of physical exercise in chronic respiratory disease	Not yet recruiting	Intervention	2021-01-22	<NULL>	<NULL>	4478	Effects of training in functional circuit on physical and functional aspects in elderly people with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-02	Universidade Federal do Parana	Universidade Federal do Parana	https://ensaiosclinicos.gov.br/rg/RBR-9p3kmn8	<NULL>	clinical diagnosis of COPD; clinically stable; without cognitive impairment; independent to perform instrumental activities of daily living; don&apos;t  use assistive devices for walking; with a medical indication for physical exercise	lung diseases such as asthma pulmonary fibrosis pneumonia and other non-pulmonary diseases such as heart disease or with sequelae of acute or chronic orthopedic and or neurological diseases that could influence the application of tests; patients who were inserted in a physical training program in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-4nzjmt	Effects of exercise in the perineal region through the use of an application in pregnant women	Not yet recruiting	Intervention	2018-12-18	<NULL>	<NULL>	4479	"Effects of pelvic floor muscle training with
mobile app in pregnant women"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4nzjmt	<NULL>	Age over 18 years; Gestational age of 16 weeks gestational; Primiparae; Presence of pelvic lining muscle strength greater than 2 by the Modified Oxford Scale; Medical authorization for physical therapy intervention; Own the mobile device with android system; • Own the mobile device with android system; Have an understanding of the functioning of the application developed by the research team; Have internet when downloading the application and for the call center; Understand the use of the platform used for the call center	Multiple gestation; Presence of bone deformities, important muscular and nervous dysfunctions; Presence of high gestational risk; Perform previous pelvic floor muscle training;; Lower urinary tract infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-67gq57	Effect of Xbox Games on the Health of children and adolescents with Down&apos;s Syndrome	Not yet recruiting	Intervention	2019-01-24	<NULL>	<NULL>	4482	Influence of Exergames in the Anthropometric, Biochemical, Metabolic and Psychomotor Profile of individuals with Down Syndrome	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-67gq57	<NULL>	Individuals with a Down Syndrome diagnosis; studing in health and education institutions in the region of Oeste Paulista; aged between 8 and 18 years; both sexes.	Children under 8 years; adolescents over 18 years of age; use of drugs that influence cardiac autonomic activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:16
RBR-9gf79b	MUSCULAR TRAINING OF THE PELVIC FLOOR VERSUS HYPHOPRESSIVE ABDOMINAL GYMNASTICS (GAH) IN URINARY SYMPTOMS, SEXUAL FUNCTION AND QUALITY OF LIFE OF CLIMATE WOMEN: RANDOMIZED CLINICAL TRIAL.	Not yet recruiting	Intervention	2018-03-01	<NULL>	<NULL>	4486	MUSCULAR TRAINING OF THE PELVIC FLOOR VERSUS HYPHOPRESSIVE ABDOMINAL GYMNASTICS (GAH) IN URINARY SYMPTOMS, SEXUAL FUNCTION AND QUALITY OF LIFE OF CLIMATE WOMEN: RANDOMIZED CLINICAL TRIAL.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-19	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9gf79b	<NULL>	"Women with clinical climacteric symptoms, such as decreased or terminated menses;
Women diagnosed with urinary incontinence or who have at least three of the symptoms
Urinary incontinence such as nocturia, urgency, urge incontinence, high voiding frequency and enuresis;
Women aged&gt; 45 years and 65 years;
Women who have had at least one sexual intercourse during the last thirty days;"	"Women allergic to latex;
Women with neurological diseases or with sensory alterations;
Use of medications for the treatment of lower urinary tract dysfunctions;
Women with previous history of pelvic floor exercises;
Women presenting a history of abdominal surgeries in the last six months;
Women diagnosed with obstructive or restrictive respiratory disease;
No attendance at the evaluation or have more than 25% of absences to the treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-7j9rv5d	Benefit of Low Intensity Laser applied to the skin in relation to viral load, LT-CD4 + AND LT-CD8 + in patients living with HIV /AIDS	Not yet recruiting	Intervention	2021-01-27	<NULL>	<NULL>	4490	Effectiveness of Transcutaneous Laserherapy in relation to viral load, LT-CD4 + and LT-CD8 + in patients living with HIV/AIDS: randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-01-04	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7j9rv5d	<NULL>	Having HIV / AIDS; both sexes; over 18 years; reside in Botucatu; perform outpatient treatment at SAEI; not having cognitive deficit; have detectable viral load; do the same therapeutic regimen	Do not reside in Botucatu; not having cognitive deficit; have an undetectable viral load	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-8mrhgcc	Evaluation of pain and quality of life using Uncaria Tomentosa (cat&apos;s claw) in patients with endometriosis	Not yet recruiting	Intervention	2021-02-01	<NULL>	<NULL>	4493	Evaluation of pain and quality of life using Uncaria Tomentosa (cat&apos;s claw) in patients with endometriosis.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-03-01	beatriz kehde	beatriz kehde	https://ensaiosclinicos.gov.br/rg/RBR-8mrhgcc	<NULL>	Inclusion criteria are patients with a diagnosis of endometriosis, confirmed by image examination, who maintain pain (visual analogue scale&gt; 5) even when using drug treatment with hormonal contraceptives for at least 3 months before inclusion in the study.	Exclusion criteria are patients without other types of clinical treatment, such as anastrozole, gestrionone, GnRH analogue; patients who are undergoing complementary treatment with physiotherapy, acupuncture, meditation; patients who are planning to become pregnant, pregnant and / or lactating, use opioid-based painkillers or who are diagnosed with another pelvic disease such as intestinal and urinary disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-10znr9xn	Impact of coordination and monitoring of care by telemonitoring on the quality of care provided to users with chronic diseases of the Unified Health System discharged from the hospital in Belo Horizonte, MG, Brazil: randomized clinical study	Not yet recruiting	Intervention	2021-02-01	<NULL>	<NULL>	4494	Impact of coordination and monitoring of care by telemonitoring on the quality of care provided to users with chronic diseases of the Unified Health System discharged from the hospital in Belo Horizonte, MG, Brazil: randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Instituto de Saúde da Comunidade da Univerisdade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-10znr9xn	<NULL>	Patients willing and able to complete the study requirements, including signing the Informed Consent Form. Patients discharged due to Congestive heart failure, Chronic obstructive pulmonary disease and diabetes mellitus requesting insulin. Patients residing in Belo Horizonte, Minas Gerais. Adult patients over 18 years old.	Pregnant or breastfeeding patients. Patients with Chronic Kidney Disease on dialysis. Cancer patients undergoing chemotherapy. Patients with diseases that reduce survival to less than six months. Patients undergoing bariatric surgery. Patients using depot corticotherapy daily use or expected use for more than fourteen days in the next six months. Patients undergoing enteral nutritional therapy. Patients unable to interview or to operate telemonitoring devices. Complete illiterate patients. Patients with severe motor and cognitive neurological sequelae. Patients with recent blood loss, severe anemia, hereditary anemia or use of blood transfusion. Patients in whom the diagnosis of exacerbated COPD has not been confirmed, having been replaced by other differential diagnoses such as left ventricular failure, pulmonary thromboembolism. Patients with clinical indication for oxygen home therapy without access to oxygen. Patients with acute myocardial infarction less than 72 hours, unstable angina less than 72 hours after stabilization. Patients with symptomatic severe valvular heart disease with surgical indication. Patients with uncontrolled arterial hypertension: SBP greater than 190mmHg and DBP greater than 120mmHg. Patients with decompensated heart failure, severe complex ventricular arrhythmias, suspected instability or severe left coronary artery injury, infective endocarditis, myocarditis or pericarditis, type A aortic dissection or acute type B phase and severe symptomatic obstruction of the ventricular outflow tract left with low effort-induced output. Patients with orthopedic or neurological conditions that overlap the respiratory condition and that limit physical activity. Patients who have acute causes of heart failure in the past 30 days, such as acute coronary syndrome, cardiac surgery or invasive procedures, implantation of devices. Patients with invasive cardiac procedures scheduled for the three months following the enrollment of participants. Patients in line for heart transplantation or with an implanted ventricular assist device. Patients with a condition that may limit compliance with study procedures such as known alcohol and drug abuse. Patients participating in other intervention studies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:17
RBR-3z23ts	Effects of a protocol of respiratory care in patients with Amyotrophic Lateral Sclerosis	Not yet recruiting	Intervention	2019-12-17	<NULL>	<NULL>	4499	Effects of an optimized respiratory care protocol in patients with amyotrophic lateral sclerosis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3z23ts	<NULL>	Inclusion criteria for the study were patients with ALS, between 18 and 70 years old, with good cognitive level to understand the evaluative tests; patients not restricted to bed; the presence of a responsible caregiver who accepts the training and follows the program; have a telephone to contact the service team.	Will be excluded from the study volunteers who are unable to perform the requested maneuvers correctly or who give up performing them during the execution for evaluation. Patients with cardiac, respiratory, musculoskeletal comorbidities, intellectual comprehension difficulty or dementia evaluated, with any other comorbidity that prevents them from performing the tests or who have difficulty performing the tests; and, smoking patients. Patients residing in regions that do not have rear medical staff in the city or in a nearby urban center; patients residing in regions of high hazard or difficult for physiotherapists to access.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:18
RBR-9qjspy7	Nursing interventions according to the disease uncertainty theory in cancer patients undergoing surgery - Clinical trial	Not yet recruiting	Intervention	2021-02-05	<NULL>	<NULL>	4512	Nursing interventions in surgical cancer patients in the light of the disease uncertainty theory - Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-10	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9qjspy7	<NULL>	Patients aged 18 years or over of both sexes who are in the postoperative period, undergoing elective surgery removed from one or multiple organs; with the diagnosis of cancer undergoing cancer treatment by the referenced hospital, and who are in full mental, cognitive and intellectual conditions to answer the questions and receive the interventions and who voluntarily agreed to sign the Free and Informed Consent Form.	Patients who are in the immediate postoperative period, do not undergo the proposed surgery and do not sign the free and informed consent form and do not voluntarily accept participation in the research will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:19
RBR-3zn7jpp	The effects of manual therapy on pain and ankle motion in collegiate athletes	Not yet recruiting	Intervention	2021-02-08	<NULL>	<NULL>	4520	Analysis of therapeutic modalities effects on human tissues	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3zn7jpp	<NULL>	Players of beach volleyball, volleyball, basketball, futsal, handball or soccer competing as athletes for the Federal University of Santa Catarina that refer pain of at least 2 mm on the VAS scale in the plantar flexors region of one limb.	Subjects with skin lesions on the leg, any metabolic condition, localized acute infections, neoplasm, severe hyperesthesia or with altered sensitivity, besides ankle fracture, sprain, instability and ligament injury.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-10gz4s59	Influence of behavioral therapies on awake bruxism, biopsychosocial factors and orofacial pain	Not yet recruiting	Intervention	2021-02-08	<NULL>	<NULL>	4522	Influence of behavioral therapies on awake bruxism, biopsychosocial factors and orofacial pain: Randomized controlled clinical trial	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-06-10	Mariana Barbosa Câmara de Souza	Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-10gz4s59	<NULL>	Adults with at least 24 teeth; diagnosed with awake bruxism; body mass index (BMI) between 18.5 and 24.9 kg, considered normal; and good general health.	Individuals under medical, psychological or pharmacological treatment; individuals that have received any therapy for awake or sleep bruxism in the past 12 months; patients with any type of prosthesis, orthodontic appliances, and those with neuropathic pain, primary headache or neuralgias.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-10wckkk7	The effects of muscle stretching in classical ballerinas	Not yet recruiting	Intervention	2021-02-09	<NULL>	<NULL>	4524	The effects of global active streching on classical dancers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-10wckkk7	<NULL>	dancers will be included in the study, aged 12 to 22 years (age group with the largest audience), who are regularly enrolled in the Studio, wish to participate in the research and sign the TCLE, TALE and DAI	those who are under 12 years old or over 22 years old, who have orthopedic injuries, in a period of recovery from injuries, who undergo some type of physical therapy treatment, who have cognitive deficit, participants who do not sign the ICF or TALE and DAI	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-65srqfv	Exercises of joint positioning sense have an effect on shoulder pain, disability and proprioception in patients with shoulder pain? Protocol for a randomized controlled trial	Not yet recruiting	Intervention	2021-02-09	<NULL>	<NULL>	4526	Exercises of joint positioning sense have an effect on proprioception, shoulder pain and disability in patients with subacromial pain syndrome? Protocol for a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-10	Universidade de São Paulo	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-65srqfv	<NULL>	Participants will be recruited through access to regulation guides for the orthopedics sector in partnership with the Municipal Health Secretariat of the city of Ribeirão Preto. Thereafter, the screening of patients will be performed at the Centro de Saúde Escola, Cuiabá, in which patients will be included in the study if they meet the following criteria: pain during active arm elevation movement (“painful arch”), positivity in the tests specific orthopedic: Neer and / or Hawkins-Kennedy, Jobe and / or pain test during resisted lateral rotation (MICHENER et al. 2009) and minimum amplitude of 120 ° of elevation.	Participants will be excluded if they have previous history of shoulder surgery or injuries caused by external forces, full tear of rotator cuff muscles evidenced by imaging, participants involved in overhead sports (such as swimming, volleyball), shoulder instability, adhesive capsulitis, severe cardiovascular and neurological diseases, carpal tunnel, pregnant women (Dilek et al., 2016).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:20
RBR-3yqmgtk	Educational strategy for truck drivers and control high blood pressure	Not yet recruiting	Intervention	2021-02-09	<NULL>	<NULL>	4531	Education strategy and control of arterial hypertension: a proposal for truck drivers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-21	Universidade de São Paulo - Escola de Enfermagem de Ribeirão Preto	Universidade Federal de Rondonópolis	https://ensaiosclinicos.gov.br/rg/RBR-3yqmgtk	<NULL>	Truck drivers with a clinical diagnosis of systemic arterial hypertension; who have a mobile phone with WhatsApp and Internet access.	Truck drivers who do not have a clinical diagnosis of systemic arterial hypertension; who do not have a cell phone; who do not have access to the internet; who have cognitive changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-6bxt49q	Transcranial Direct Current Stimulation in Elderly Depression	Not yet recruiting	Intervention	2021-02-10	<NULL>	<NULL>	4538	Transcranial Direct Current Stimulation in Geriatric Depression	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-15	Clínica Physio Line	Clínica Physio Line	https://ensaiosclinicos.gov.br/rg/RBR-6bxt49q	<NULL>	Will be admitted to this study: who is over 65 years old on the day of the first assessment; in use of antidepressants stable for at least 6 months, diagnosed of major depressive disorder; who is right-handed; and mild to moderate depression, indicating they are resistant to treatment with pharmacological therapy and / or psychotherapy (taken by the Geriatric Depression Scale).	The elderly will not participate in the investigation: using sedatives, anticonvulsants, amantadine or memantine during the study; who has consumed caffeine on the day of stimulation; with a previous history of stroke, epilepsy, traumatic brain injury, unexplained loss of consciousness; in unstable medical conditions; who has metallic objects in the skull, excluding in the mouth, for example, shrapnel; undergoing craniotomy or head injury; who has disease that caused brain damage or neurological disease; using pacemaker (bypass); participating on another concomitant clinical trial; medication change during the study; with Cognitive Impairment (assessed by the Montreal Cognitive Assessment - MoCA, score below 26); diagnosis of Dementia; scores below 10 - because they are not depressed, or above 21 on the Geriatric Depression Scale because there is evidence that ETCC works better in mild to moderate depression (Gálvez et al., 2015).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-5j3j9z9	Chemoradiation and Consolidation Chemotherapy with or without oxaliplatin for distal rectal cancer and Watch and Wait. A multi-center prospective randomized controlled trial. (CCHOWW)	Not yet recruiting	Intervention	2021-02-10	<NULL>	<NULL>	4539	Chemoradiation and Consolidation Chemotherapy with or without oxaliplatin for distal rectal cancer and Watch and Wait. A multi-center prospective randomized controlled trial. (CCHOWW)	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-04-01	Hospital Alemão Oswaldo Cruz	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-5j3j9z9	<NULL>	"1.	Age ≥18 years;
2.	ECOG 0-2 or KPS≥70;
3.	Primary rectal adenocarcinoma (biopsy confirmed) within the reach of digital rectal examination (at least lower tip/border) by the attending colorectal surgeon;
4.	Endoscopic documentation;
5.	Abdominal and chest CT scans showing no evidence of metastatic disease;
6.	High-resolution magnetic resonance images performed at either 1.5T or 3.0T system using a phased array surface coil with: sagittal T2 images including the anal verge and the sacrum; axial oblique T2 weighted images acquired in a plane perpendicular to the long axis of the rectal wall guided by the sagittal images; coronal images acquired in parallel to the anal canal plane. Small field of view (16-18cm), 3mm section thickness, increased matrix size and increased number of signal averages are required;
7.	Radiological defining criteria (centralized):
a.	Lower edge of tumor at the level (max. 1cm distance) or below the anorectal ring defined at sagittal or coronal views;
b.	mrT2, mrT3 (any subclassification) 
c.	mrN0-1 (≤3 radiologically positive lymph nodes)
d.	mrEMVI: any status
e.	mrMRF: any status"	"1.	Pregnancy
2.	ECOG ≥3 or KPS&lt;70
3.	Unwilling to consent
4.	Metastatic disease (any kind; internal iliac and obturator nodes are considered local disease and not metastatic disease and therefore will not be considered as exclusion criteria)
5.	mrT4 or mrN2
6.	Previous pelvic irradiation
7.	Baseline neuropathy
8.	Receiving treatment of other anti-cancer drug or methods
9.	Presence of uncontrolled life threatening diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:21
RBR-2gb34zr	Educational activities and group physiotherapy to prevent falls in the elderly	Not yet recruiting	Intervention	2021-02-11	<NULL>	<NULL>	4541	Education actions and group Physiotherapy at the risk of falls in the elderly: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-2gb34zr	<NULL>	Seniors; Age equal to or above 60 years; Gender-independent.	Bedridden; Wheelchair users; They use auxiliary device; Score equal to or less than 24 points in the Mini Mental State Examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-102v5xpf	Diagnosis variability in psychiatry secondary to medical evaluation strategy.	Not yet recruiting	Intervention	2021-02-11	<NULL>	<NULL>	4542	Comparing diagnosis in mental health with different modes of interview.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade Federal do Rio de Janeiro - Instituto de Psiquiatria da UFRJ	Faculdade de Medicina da Universidade de Lisboa	https://ensaiosclinicos.gov.br/rg/RBR-102v5xpf	<NULL>	"Patients: Being under the assistance of the same doctor or assistant group for, at least, one year. Agreeing to participate and signing the free and informed consignment term.
Doctors:Agreeing to participate and signing the free and informed consignment term."	Subjects in mutism, intense negativism, with incomprehensible discourse or so agitated that is incapable to be submitted to a diagnose interview.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-8gzp4f4	Educational Practice on patient Safety: health experiment	Not yet recruiting	Intervention	2021-02-11	<NULL>	<NULL>	4543	Educational Intervention on patient Safety: quasi-experimental research	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-15	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8gzp4f4	<NULL>	"The population of interest will be composed of health users admitted to a hospital and the sample recruited from the medical clinic ward of the referred institution. Potentially eligible patients will first have the medical record analyzed by the researcher, considering as inclusion criteria:

- Be over 18 years old;
- Both sexes;
- Have clinical conditions to answer the questions and participate in the educational intervention (medical and nursing records must be included in the patients&apos; medical records that the patients are aware of, oriented, communicating without difficulty. The clinical conditions will be questioned by the researcher to the nurse or responsible physician, who must confirm that patients are not in a serious or clinically unstable state);
- Accept to participate in the research."	Patients who have an inability to understand the questions of the instruments and educational intervention (evaluated through the records in the patient&apos;s medical record).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-103k2gpz	Assessment of consumption of processed foods and eating behavior in adults with obesity	Not yet recruiting	Observational	2021-02-12	<NULL>	<NULL>	4544	Assessment of Ultra-processing Food and Eating Behavior in Obesity Adults	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-103k2gpz	<NULL>	Adults; both sexes; age from 18 to 59 years; body mass index (BMI) ≥ 30 kg / m²	Volunteers undergoing clinical and / or drug treatments for weight reduction; use of cortisone and antiepileptic drugs; history of kidney and heart disease; alcohol abuse; smoking; use of vitamin supplementation; diagnosis of obesity due to genetic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-44vznyc	Nurse-led strategy to improve the Care Transition in patients undergoing colorectal cancer surgery	Not yet recruiting	Intervention	2021-02-12	<NULL>	<NULL>	4548	Development, evaluation, and implementation of a Care Transition Strategy for patients with Colorectal Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-44vznyc	<NULL>	All patients with colorectal cancer who underwent surgery; aged between 18 and 85 years; with or without companion; who have preserved cognitive activity or with a family member/caregiver.	Patients who do not have access to a fixed or mobile phone line will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-5cyvzh9	Effects of a semi-supervised home-based exercise training on physical, mental performance and body composition on primary lung and head and/or neck cancer patients: a randomized clinical trial	Not yet recruiting	Intervention	2021-02-12	<NULL>	<NULL>	4549	Effects of a semi-supervised home-based exercise training on physical performance, biological and mental outcomes on primary lung and head, and/or neck cancer patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-15	Universidade Estadual Julio de Mesquita Filho - UNESP	Ercy Mara Cipulo Ramos	https://ensaiosclinicos.gov.br/rg/RBR-5cyvzh9	<NULL>	Diagnosis of primary lung or head and/or neck cancer; older than 18 years; being literate or has a family member who helps with daily training; having a schedule of oncology treatment (radiotherapy, chemotherapy or both); ECOG between 0 and 2;  more than six months of medical prognosis; do not have uncontrolled metabolic diseases; do not have cognitive changes that can interfere the training; do not have musculoskeletal and cardiovascular changes that can interfere the training	Primary cancer from another organ with pulmonary or head and/or neck metastasis; symptomatic brain metastasis that can interfere in the training; symptomatic bone metastasis that can interfere in the training; patient under palliative care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:22
RBR-104t6bj4	Online training to improve health and wellbeing among medical students	Not yet recruiting	Intervention	2021-02-19	<NULL>	<NULL>	4553	Online training to improve health and quality of life among medical students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-22	Escola Paulista de Medicina - Universidade Federal de Sao Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104t6bj4	<NULL>	To be at least 18 years old; to be enrolled in the second academic year of the medical course at one of the seven participating medical schools; to confirmation his/her availability to participate in the intervention phase of the study; to give his/her consent to participate in the study.	Failing to complete the instruments regarding the assessment of depressive symptoms and suicidal thoughts/plans on the database assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-7xvpbw3	Benefits of using video calls compared to using a cell phone app on the rate of smoking cessation, post-stop symptoms and levels of Anxiety and Depression	Not yet recruiting	Intervention	2021-02-22	<NULL>	<NULL>	4554	Efficacy of synchronous call center compared to the use of cell phone application in Smoking Cessation Rate, Withdrawal Syndrome and Anxiety and Depression level	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade do Oeste Paulista (UNOESTE)	Universidade do Oeste Paulista (UNOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7xvpbw3	<NULL>	The study will include individuals over 18 years of age, of both sexes, smokers for at least 1 year, including smokers of tobacco derivatives such as string cigarettes, cigars, cigarillos and water pipes (hookahs), without reports of severe psychiatric morbidities. , such as schizophrenia or bipolarity previously diagnosed, literate and able cognitively to answer the evaluations and questionnaires of the study.	Individuals with an IOS smartphone that are incompatible with the app and who abandon treatment during the study will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-6vb67s2	Evaluation of self-esteem, self-image and level of hope in patients with gastrointestinal neoplasia under chemotherapy treatment	Not yet recruiting	Intervention	2021-02-25	<NULL>	<NULL>	4560	Evaluation of self-esteem, self-image and level of hope in patients with gastrointestinal neoplasia under chemotherapy treatment: an almost experimental study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-6vb67s2	<NULL>	Patients diagnosed with AC with gastrointestinal cancer aged 18 years or older undergoing antineoplastic chemotherapy after a surgical procedure treated at the Chemotherapy Center of the Hospital de Clínicas, Universidade Federal do Triângulo Mineiro (CQT / HC / UFTM).	Patients who underwent previous antineoplastic chemotherapy treatment; change in chemotherapy treatment during the study, those who are unable to maintain a dialogue and do not have clinical conditions to respond to the proposed instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-877q82j	Amamentacoach: a mobile strategy for breastfeeding reterm infants	Not yet recruiting	Intervention	2021-03-02	<NULL>	<NULL>	4562	Nursing Coaching by App: an innovative approach to breastfeeding preterm infants	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-877q82j	<NULL>	The following inclusion criteria will be considered for mothers, having given birth at the University Hospital of the State University of Londrina; referring to the desire to breastfeed; not having any contraindications to breastfeeding; having a smatrphone and presenting voluntary agreement to participate in the study and signing the informed consent form. The following inclusion criteria will be considered for infants, gestational age of birth less than 37 weeks; absence of congenital malformations, genetic syndromes, hypoxic-ischemic encephalopathy and or conditions that imply contraindication or impediment to breastfeeding.	Maternal death during the study; death of the baby less than one week after inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:23
RBR-458tbcd	Effects of an intervention based on Eating with Full Attention in patients who underwent Stomach Reduction Surgery and regained weight: a randomized clinical trial	Not yet recruiting	Intervention	2021-03-05	<NULL>	<NULL>	4566	Effects of the Mindfulness-Based Food Awareness Training intervention (Mindfulness-Based Eating Awareness Training - MB-EAT) in patients after Bariatric Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-458tbcd	<NULL>	Present weight regain after bariatric surgery; bariatric surgery was performed in the last five years (minimum 2 years after surgery), reported binge eating episodes and accepted to participate in the study. Weight gain will be considered for participants who recover 50% of the lost weight achieved in the long term or recovery of 20% of the weight associated with the reappearance of comorbidities (SBCBM, 2015). Binge eating episodes are those participants who meet the criteria established by DSM-V (2014): Eating within a limited period of time (for example, within a period of 2 hours), a quantity of food definitely greater than most people would consume at a similar time, under similar circumstances and feeling of lack of control over the episode (a feeling of not being able to stop or control what or how much one eats)	Current diet for weight loss or use of medications that can affect weight; pregnancy; breast-feeding; presence of psychiatric disorders; personality disorders; severe depression; alcohol abuse and / or being on psychiatric drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-8ht6j7q	Prevention of Skin Cancer with nicotinamide in Transplant recipients	Not yet recruiting	Intervention	2021-03-16	<NULL>	<NULL>	4572	Nicotinamide as chemoprevention of Skin Cancer in Transplant recipietns	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-05-10	Irmandade Santa Casa de Misericordia de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8ht6j7q	<NULL>	Patients older than 18 years; transplanted at least one year ago; with diagnosis of at least two NMSC in the last 12 months; who accept to participate in the study and agree to take the medication or placebo, by signing an Informed Consent Form.	Patients who do not wish to participate in the study; patients with impaired renal; hepatic or clotting function; patients who had malignant internal organ tumors in the last 5 years or malignant tumor metastases; pregnant or lactating women; patients on hemodialysis or peritoneal dialysis; patients who underwent treatment for actinic keratoses in the last 4 weeks; patients using systemic retinoids or with previous use of nicotinamide in the last 4 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:24
RBR-10yqwrk6	Double blind randomized clinical trial of &quot;Espinheira Santa&quot; as a strategy of management of dyspepsia in gastroesophageal reflux disease	Not yet recruiting	Intervention	2021-03-26	<NULL>	<NULL>	4581	Double-blind randomized clinical trial of Maytenus ilicifolia as a strategy to manage dyspepsia in gastroesophageal reflux disease	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10yqwrk6	<NULL>	Voluntary patients, of both sexes, aged between 18 and 60 years who are looking for medical attention in Health Units and who, after medical evaluation, present symptoms of dyspepsia, at least two of these symptoms, regurgitation, taste of sour or bitter fluid in the mouth, and/or epigastric pain and/or burning pain (ascending or not) in the week before the consultation, of gastroesophageal reflux disease. Patients able to be treated without endoscopic investigation and without evidence of disease or use of medication that justifies the symptoms will be included.	Patients who are referred for an endoscopic examination and who are intolerant to the treatment compounds will be excluded from the medical evaluation. Pregnant women or women of reproductive age who do not use hormonal contraceptives will be excluded. Patients with a history of glaucoma, paralytic ileum, stenosis or mechanical obstruction of the gastrointestinal tract, megacolon, patients with acute-angle glaucoma, urinary retention or prostate hyperplasia will be excluded patients using any drugs with antiulcer or prokinetic properties in the week prior to recruitment that present structural changes related to reflux and dyspepsia, such as hiatus hernia and esophageal atresia, hepatopathies and patients using drugs that make pharmacological interaction with compounds of Maytenus ilicifolia dry extract.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-2tjqwwj	Effect of a high intensity training program with different protocols in the pool environment on physical capacities, body composition (lean weight and fat weight), heart rate and blood pressure.	Not yet recruiting	Intervention	2021-03-28	<NULL>	<NULL>	4587	"Effect of a high intensity interval training program with different
physical exercise protocols performed on the ground and within the aquatic environment
on variables, metabolic, hemodynamic, anthropometric and functional."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-05	Escola Superior de Educação Física	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2tjqwwj	<NULL>	Physically active men; Be aged between 18-25 years; Not having a history of musculoskeletal injury; Not presenting diagnoses of cardiometabolic diseases; Answer NO to all questions in the Physical Activity Readiness Questionnaire (PAR-Q) and Sign the free and informed consent form (ICF).	Not attending the evaluation calendar; Present any major injury or discomfort that makes it impossible to continue the research and Start another physical exercise practice during the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:25
RBR-39ntmjk	Evaluation of the use of sodium hypochlorite in the tooth before bonding orthodontic appliances	Not yet recruiting	Intervention	2021-03-29	<NULL>	<NULL>	4590	Evaluation of the influence of enamel deproteinization on the adhesion of orthodontic accessories	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Centro Universitário Ingá / UNINGÁ	Centro Universitário Ingá / UNINGÁ	https://ensaiosclinicos.gov.br/rg/RBR-39ntmjk	<NULL>	Patients with indication for fixed orthodontic treatment without tooth extractions. Complete permanent dentition in the maxillary arch until first molars (10 teeth) present, erupted, absent from caries, erosion, friction, attrition, abrasion, enamel hypoplasia, imperfect amelogenesis, without restorations, or anomalies in the vestibular surfaces;	Not applicable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-10gb3p94	Exercise for recovered Covid-19 patients	Not yet recruiting	Intervention	2021-04-02	<NULL>	<NULL>	4597	Effects of a rehabilitation program on the inflammatory profile and functional capacity of patients recovered from COVID-19	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-05	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-10gb3p94	<NULL>	All patients over 18 with a history of hospitalization for Sars-COVID-19; who are able to perform physical tests and who accept to participate in the rehabilitation protocol	individuals who have incomplete data; who do not sign the consent form; unable to perform physical evaluations; who do not accept to perform blood collection; unable to travel to the rehabilitation center	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-97g2phk	Suboccipital Muscle Manual Therapy in the Human Brain	Not yet recruiting	Observational	2021-04-05	<NULL>	<NULL>	4599	Effects of Manual Therapy of the Suboccipital Musculature in the Modulation of Encephalographic Parameters of the Human Brain	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-04-05	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-97g2phk	<NULL>	good health; without significant neurological history	any kind of drug consumption; &lt;18 yeards old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:26
RBR-4j9wkbz	"Short-term effects of a Exercise through Telerehabilitation, 
in confined patients affected by Covid-19"	Not yet recruiting	Intervention	2021-04-05	<NULL>	<NULL>	4601	"Short-term effects of a Toning Exercise Program through Telerehabilitation,
in confined patients affected by Covid-19"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-05	Universidad de Sevilla	Universidad de Sevilla	https://ensaiosclinicos.gov.br/rg/RBR-4j9wkbz	<NULL>	Patients between 18-75 years who are affected by coronavirus (COVID-19), and are in home confinement.	Patients with chronic lung conditions; Patients with chronic kidney disease; Patients affected with chronic neurological disorders; Patients suffering from hypertension and cardiovascular conditions without medical treatment; Patients affected with grade III osteoporosis; Patients affected with acute outbreaks of rheumatologic disorders; Patients affected with acute outbreaks disc abnormalities; Patients who have had respiratory conditions in the last 12 months; Patients who have recent musculoskeletal disorders, and who are not fully recovered from their injuries; Patients who have received physical therapy treatment in the last 3 months; Patients affected with chronic mental and / or psychological disturbances; Red Flags (Night pain, severe muscle spasm, loss of involuntary weight, symptom mismatch)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:27
RBR-3y8w4w3	Promotion of Physical Activity in primary health care	Not yet recruiting	Intervention	2021-04-08	<NULL>	<NULL>	4611	Promotion of Physical Activity in primary health care: a prospective, randomized and controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3y8w4w3	<NULL>	Users of Basic Health Units or Family Health Units in the city of Bauru without decompensated cardiovascular and/or pulmonary disease, and with no absolute contraindications for the practice of physical exercise (i.e.: acute myocardial infarction; unstable unstable angina; uncontrolled cardiac arrhythmias with hemodynamic repercussions; symptomatic severe aortic stenosis; uncontrolled symptomatic heart failure; acute pulmonary embolism or pulmonary infarction; myocarditis or acute pericarditis; acute aortic dissection).	Age below 18 years or above 80 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-108fyykd	Evaluation of safety, effectiveness and duration of immunity after vaccination against Covid-19 in patients with autoimmune rheumatic diseases	Not yet recruiting	Observational	2021-04-14	<NULL>	<NULL>	4613	Safety, effectiveness and duration of immunity after vaccionation against new SARS-COV2 in patients with immunomediated rheumatic diseases	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-04-27	Universidade Federal de São Paulo	Sociedade Brasileira de Reumatologia	https://ensaiosclinicos.gov.br/rg/RBR-108fyykd	<NULL>	rheumatoid arthritis; systemic lupus erythematosus; Sjogren&apos;s syndrome; systemic sclerosis; myopathies; vasculitis; spondyloarthritis; both sexes; age above eighteen years; medical indication to vaccinate against covid-19	Immunosuppressed by other causes; HIV; CD4 below two hundred cells; organ transplantation; primary immunodeficiency; cancer; myasthenia gravis; thymoma; absence or surgical removal of the thymus; pregnancy; history of severe adverse reaction to any vaccine previously administered	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-1044sz68	Effectiveness and tolerance of Deep Peeling compared to Imiquimod cream in the treatment of Actinic Cheilitis	Not yet recruiting	Intervention	2021-04-19	<NULL>	<NULL>	4615	Effectiveness and tolerance of Phenol-Croton Peel 1,6% versus Imiquimode in the treatment of Actinic Queilites: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	UNESP - Universidade Estadual Paulista	UNESP - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-1044sz68	<NULL>	Sign the Informed Consent Form; age over 18 years of both sexes; present histological diagnosis of QA in the lower lip.	Phototypes V and VI; selected treatment area that has atypical clinical appearance or other dermatoses; current and previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; present current or previous diagnosis of CPB on the lower lip; present hypersensitivity or allergy to any of the substances under study; any treatment for QA in the last 8 weeks except photoprotection; suspected or confirmed pregnancy; women of childbearing potential who do not use contraception; women who are breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-6tm67h3	Minimally invasive treatment of teeth with deep caries and a history of spontaneous pain	Not yet recruiting	Intervention	2021-05-04	<NULL>	<NULL>	4617	Vital Pulp Therapy in permanent teeth with signs of Pulpitis	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-03-31	Fundação de Amparo a Pesquisa do estado do Rio Grando do Sul	Fundação de Amparo a Pesquisa do estado do Rio Grando do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6tm67h3	<NULL>	Patients with permanent tooth (older than 7 years) with a deep caries lesion with a clinical pulp diagnosis of moderate pulpitis (irreversible pulpitis) will be included in the study, according to the pulp diagnostic system described by Wolters and collaborators in 2017 (Moderate pulpitis - Clear symptoms, strong, heightened and prolonged reaction to cold (-20ºC)), which can last for minutes; Possibly percussion sensitive and spontaneous dull pain that can be more or less suppressed with pain medication; With or without periodontal ligament spacing thickening; Patients who accept to participate, their guardians authorize to participate in the research, and sign the free and informed consent form (TCLE) will be included.	Patients who do not have enough remaining dental tissue to receive direct restoration will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-3pd52f	Chronic effect of Strengthening associated with Blood Flow Restriction on Strength, Power and Muscle Activation in healthy women: a randomized, blinded clinical trial	Not yet recruiting	Intervention	2020-09-28	<NULL>	<NULL>	4619	Chronic Effect of Resistance Exercise associated with Blood Flow Restriction on Neuromotor Performance in healthy women: clinical trial, randomized and blinded	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-30	Caio Alano de Almeida Lins	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	https://ensaiosclinicos.gov.br/rg/RBR-3pd52f	<NULL>	Women aged between 18 and 35 will be included and classified as irregularly active according to the International Physical Activity Questionnaires (IPAQ). The participant will be eligible for the study if she has a body mass index (BMI) between 18.5 and 30kg / m²; not have previous experience with training of blood flow restriction; not having diabetes mellitus or high blood pressure; not be a smoker; not using vasoactive medications or nutritional supplements regularly; not having presented an upper limb injury in the last 6 months; not having any severe rheumatic, cardiovascular or severe inflammatory or pulmonary conditions that prevent the performance of the assessments and the exercise protocol; not having any psychiatric illness or malignant tumor and not having contracted Zika or Chikungunya in the last year; not having undergone regular physical training for upper limbs in the last six months.	Participants who wish to leave the study will be excluded; have disabling health conditions that make it impossible for them to continue; use analgesic and / or anti-inflammatory resources that can interfere with any result; perform unusual or strenuous physical activities during the study period; consecutively miss sessions 29, or fail to meet at least 70% of the entire training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-10z85rcz	Effect of the heat transmitted by a waves device for the treatment of vulvar lichen sclerosus	Not yet recruiting	Intervention	2021-05-05	<NULL>	<NULL>	4620	Non-ablative radiofrequency as treatment of vulvar Lichen Sclerosus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-07	Faculdade de Medicina da Universidade Federal do Rio Grande do Sul	Fundo de Incentivo à Pesquisa do Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10z85rcz	<NULL>	women with clinical suspicion of vulvar lichen sclerosus, whose diagnosis is confirmed by biopsy, wich accept to participate in the study and sign the term of consent	vulva cancer at inicial biopsy, diagnosis other than lichen sclerosus in the inicial biopsy, current treatment with topical steroid in the vulva, transplanted, pregnant or lactating women and hiv carriers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-23y7xm3	Effectiveness of a Treatment Protocol Non-invasive Brain Stimulation and Oculomotor Physiotherapy in the Eye Movement of Adults with Parkinson	Not yet recruiting	Intervention	2021-05-05	<NULL>	<NULL>	4621	Effectiveness of a Treatment Protocol with Transcranial Direct Current Stimulation and Oculomotor Physiotherapy in the Saccadic Movement of Adults with Parkinson	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-23y7xm3	<NULL>	Volunteers with Parkinson&apos;s disease. Able to walk. Normal or corrected visual acuity. Preserved cognitive ability.	Persons with Aphasia of understanding. Individuals with cataracts. Retinal detachment. Macular degeneration. Low vision. Those who do not obtain 75% attendance during the intervention. Cognitive decline.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:28
RBR-42b3r23	Evaluation of the Impact of Gingivitis treatment on muscle profile	Not yet recruiting	Intervention	2021-05-05	<NULL>	<NULL>	4622	Evaluation of the Impact of Gingivitis treatment on muscle profile: a clinical-biochemical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-16	Centro de Ensino dos Campos Gerais	Centro de Ensino dos Campos Gerais	https://ensaiosclinicos.gov.br/rg/RBR-42b3r23	<NULL>	Systemically healthy patients, who do not usually perform routine physical activities, aged between 25 and 60 years, with at least 20 natural teeth with mild gingivitis at the probing depth between 4-6 mm and / or loss of clinical insertion of 3-4mm	Patients with some type of chronic non-communicable disease or inflammatory diseases, such as diabetes mellitus or rheumatoid arthritis, women, patients who have used antibiotics, steroids or non-steroidal anti-inflammatory drugs in the last three months and smokers will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-5r2rz6c	Manufacture of a valve against reflux by endoscopy, in patients who treated megaesophagus by endoscopy	Not yet recruiting	Intervention	2021-05-06	<NULL>	<NULL>	4625	Transoral fundoplication without incision using the EsophyX Z ® device to control gastroesophageal reflux disease after peroral endoscopic myotomy (POEM), in patients with achalasia: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5r2rz6c	<NULL>	Age greater than or equal to 18 years; Patients with an established diagnosis of achalasia (primary or secondary), confirmed by an esophageal manometry test and who has undergone endoscopic treatment (POEM) and subsequently evolved with GERD, confirmed through a 24-hour esophageal pH-metry examination, in addition to clinical symptoms (heartburn, regurgitation) with or without endoscopic findings of erosive esophagitis; 24h PHmetry (performed after POEM) showing pathological reflux (defined as the total% of time - acid exposure time, pH &lt;4.0) is&gt; 6% or a DeMeester score&gt; 14.7, according to the one established in the Lyon Consensus20; The individual who agrees to participate in the study and signs the free and informed consent form	Pregnancy; Body mass index (BMI) ≥ 30 kg / m2; Hiatal hernia&gt; 2 cm; Surgical myotomy with prior fundoplication; Persistent dysphagia, weight loss or oesophageal bleeding; Barrett&apos;s esophagus; Any active medical condition that prevents the study from being completed; Coagulopathy or chronic use of anticoagulants; Esophageal or gastric varices; esophageal ulcers; Delay in gastric emptying; Neoplasms, esophageal, gastric or duodenal strictures, or any other important anatomical alteration of the upper digestive tract that may make the procedure impossible; When you are not receiving anti-reflux medication, the base score of the GERD-HRQL form is less than or equal to 12	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-87bg28	Effectiveness of a psychoeducation program to reduce barriers and stigmas of patients with breast cancer in relation to palliative care	Not yet recruiting	Intervention	2020-08-18	<NULL>	<NULL>	4635	Effectiveness of a psychoeducation program to reduce barriers and stigmas of patients with breast cancer in relation to palliative care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-10	Fundação Pio XII	Barretos Cancer Hospital	https://ensaiosclinicos.gov.br/rg/RBR-87bg28	<NULL>	Women; aged between 18 and 75 years; Present a diagnosis of advanced breast cancer and have knowledge of the disease; being under palliative chemotherapy with Paclitaxel and who do not meet the criteria for immediate palliative care, in accordance with the Palliative Care Referral Protocol in force at the institution; With life expectancy greater than 6 months, at the discretion of the clinical oncologist; Be classified according to the functionality scale of the Estern Cooperative Oncology Group, with an index greater than 2 on the scale.	Being under drug treatment for mental disorders; Manifest cognitive, attention, language and orientation deficits, preventing questionnaires and instruments, according to screening criteria of the Mini Mental State Examination, considering cut-off points of 17 points for illiterates, 22 points for 1 to 4 years of age. schooling, 24 points from 5 to 8 years of schooling and 26 points for 9 or more years of schooling; Need assistance or have an appointment at the palliative care unit due to advanced cancer, in accordance with the Palliative Care Referral Protocol; Have a diagnosis of advanced cancer, with no possibility of cure and associated with any of the criteria for referral for palliative care according to PECP; Present any comorbidity that, in the opinion of the researchers, prohibits the patient from participating in the study; Weekly visits to the hospital are not available.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:29
RBR-2ys36cq	Effects of therapeutic hammock in hospitalized preterm newborns	Not yet recruiting	Intervention	2021-05-13	<NULL>	<NULL>	4648	Effects of positioning hammock on the neurodevelopment and clinical outputs of preterm infants: randomized controlled clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de Mato Grosso do Sul (UFMS)	Universidade Federal de Mato Grosso do Sul (UFMS)	https://ensaiosclinicos.gov.br/rg/RBR-2ys36cq	<NULL>	Preterm infants with corrected gestational age equal to 34 weeks; with more than 72 hours of postnatal life; hospitalized in a neonatal unit, with a stable clinical condition; with generalized movements of poor repertoire characteristic; without the need for invasive or noninvasive mechanical ventilation;	Those with congenital malformations, degree 3 and 4 periintraventricular hemorrhage, osteomyoarticular disorders, use of central nervous system depressants and use of invasive or noninvasive mechanical ventilation will not be included. The study will use analysis by intention to treat, that is, all participants included will be considered. However, only those whose parents request the removal of the infant from the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-4jh63b	Stem Cells for Severe COVID-19 patients	Not yet recruiting	Intervention	2020-11-19	<NULL>	<NULL>	4649	Mesenchymal stem cells for patients with Acute Respiratory Distress Syndrome and mechanical ventilation caused by COVID-19: a phase I/II study	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2021-07-10	StemCorp	StemCorp	https://ensaiosclinicos.gov.br/rg/RBR-4jh63b	<NULL>	Patients aged 18 years or older; Admission to the ICU by COVID-19, confirmed by positive RT-PCR for SARS-CoV-2 (test registered by ANVISA); Diagnosis of acute respiratory distress syndrome related to COVID-19 and defined by changes in radiological images, gas exchange and the need for invasive mechanical ventilation (WHO classification 7 or higher); Be on invasive mechanical ventilation for a period greater than or equal to seven days; Absence of weaning from mechanical ventilation in the next 24 hours.	Patients who are part of experimental treatments or who have participated in any clinical trial in the last 3 months; Patients who have some type of active cancer, according to the medical record of the ICU, which is generally based on clinical history obtained with the patient&apos;s family members; Patients with an autoimmune disease, according to the medical record of the ICU, which is generally based on clinical history obtained with the patient&apos;s family members; Pregnant and lactating patients. For female patients in reproductive age, a hCG test will be collected to exclude the possibility of pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:30
RBR-34f2px4	The effect of pharmaceutical care intervention on health care and the safety of medication use in hospitalized elderly	Not yet recruiting	Intervention	2021-05-14	<NULL>	<NULL>	4659	The impact of pharmaceutical care in the context of individualized-centered health care for the safety of pharmacotherapy in hospitalized elderly: a clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP)	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-34f2px4	<NULL>	Being 60 years old or more; being on one or more prescription drugs; have a source of confirmation of the drugs you routinely use, such as medical records or history of care in primary health care, or be aware to report this information, or even have a companion who holds this data about your treatment; to be admitted to the geriatric ward for at least 24 hours and, after this time has elapsed, not to be discharged from the hospital already scheduled; consent to participate in the study and sign, or the responsible person, the informed consent form	Withdraw the consent to participate in the course of the research, due to the individual&apos;s will or the person responsible for it	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-1072m6nv	Effects of subcutaneous ketamine on depression	Not yet recruiting	Observational	2021-05-17	<NULL>	<NULL>	4660	Effects of subcutaneous ketamine on treatment resistant depression	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-07-15	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-1072m6nv	<NULL>	Patients in current severe depressive episode, occurring for at least 4 weeks, and who have already used at least two antidepressant drugs, in an appropriate dose and duration; age between 18 and 45 years old.	uncontrolled hypertension; congestive heart failure or other evidence of impaired cardiac status; COPD; severe obesity; increased intracranial or cerebrospinal pressure; pregnancy; hyperthyroidism; adverse response to ketamine; present or past psychotic symptoms; dissociative identity disorder; autism spectrum disorder; prodromal symptoms of schizophrenia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-3tzxg2	Effectiveness of a Flowchart as an Educator for Breastfeeding Assistance in Premature Newborns	Not yet recruiting	Intervention	2020-02-27	<NULL>	<NULL>	4661	Effectiveness of a Flowchart as a Guide for the Clinical Management of Breastfeeding in Premature Newborns	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-3tzxg2	<NULL>	Performance in the management of breastfeeding with the premature newborn; for at least six months.	Not have taken part in the first phase of the research; to be on vacation; to be on certified or absent from the service; impossibility for any reason to complete all the steps provided for in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:31
RBR-3xk4qkq	The Effects of Metoprolol on the Cardiorespiratory Response to orotracheal extubation: prospective, randomized, double-blind, placebo-controlled clinical trial	Not yet recruiting	Intervention	2021-05-21	<NULL>	<NULL>	4668	The Effects of Metoprolol on the Hemodynamic and Respiratory response to orotraqueal extubation: prospective, randomized, double-blinded and placebo-controlled trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital de Base do Distrito Federal	Hospital de Base do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-3xk4qkq	<NULL>	Patients aged between 18 and 60 years, scheduled to undergo surgery under general anesthesia. Physical status 1 2 and 3 of the American Society of Anesthesiology (ASA).	Patients with contraindications or a history of hypersensitivity to the drugs involved in the study. Patients with heart, lung, kidney, liver or neurological disease. Patients who refuse to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-6rkgsg8	Evaluation of the efficacy of personalized TMJ prosthesis compared to non-personalized TMJ prosthesis: a follow-up study	Not yet recruiting	Intervention	2021-05-25	<NULL>	<NULL>	4671	Comparison of the customized TMJ prosthesis with the stock TMJ prosthesis: a prospective study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-03	Complexo de Saúde São João de Deus	Complexo de Saúde São João de Deus	https://ensaiosclinicos.gov.br/rg/RBR-6rkgsg8	<NULL>	Patients 18 years or older presenting consolidated bone conformation; in advanced stages of temporomandibular joint disorders; in which traditional and conservative approaches have already been tried and have failed; such as osteoarthritis; tumors; trauma; inflammatory or degenerative pathologies of the temporomandibular joint (TMJ); autoimmune tissue connective diseases affecting the TMJ; fibrous or bone ankylosis; missing or deformed structures and spondyloarthropathies.	Patients in constant use of analgesics or anti-inflammatory drugs; syndromic; immunosuppressed; diabetic patients with uncontrolled coagulopathies; and hypertensive patients. Participants will also be excluded from the study if they have other treatment alternatives; have uncontrollable masticatory muscle hyperfunction such as bruxism; or known allergy to prothesis&apos; material; Participants previously implanted with ATM prostheses will also be excluded from the study; as well as participants who need reconstruction that is not restricted to the branch and that encompasses the mandibular body.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-9ksh5f4	Study to evaluate the effects of the COVID-19 (inactivated) vaccine of the Instituto Butantan in immucompromised persons	Not yet recruiting	Intervention	2021-05-26	<NULL>	<NULL>	4672	Phase IV study to evaluate the safety and immunogenicity of the Covid-19 adserbed (inactivated) vaccine of the Instituto Butantan in immunocompromised hosts	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2021-05-31	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Centro de Farmacovigilância, Segurança Clínica e Gestão de Risco, Instituto Butantan	https://ensaiosclinicos.gov.br/rg/RBR-9ksh5f4	<NULL>	Adults aged from 18 to 59 years, belonging to one of the following groups: Solid organs transplant recipients - kidney, liver, heart and lung; Chronic Kidney disease pre-transplantation; Liver cirrhosis pre-transplantation; Hematopoietic stem cell transplantation; Cancer in active therapy; Adults with innate immunity errors, diseases with predominant antibody deficiency; Immune-mediated rheumatic diseases; Immunocompetent persons (comparator group)	Have previously received any Covid vaccine; History of allergy to any component of the vaccine;  Have received any other vaccine up to 15 days before inclusion in the study; Acute illness or fever at the time of inclusion; Behavioral, cognitive or psychiatric illness that, in the opinion of the researchers, affects the ability to understand and collaborate with the requirements of the research protocol Alcohol or drug addiction; Any other condition that, according to the investigator&apos;s judgment, may prejudice the study procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-4fw4f7	Effects of Neuromuscular Approach Techniques to reduce Knee Injury Risk Factors in amateur runners	Not yet recruiting	Intervention	2020-04-22	<NULL>	<NULL>	4676	The comparison between Neuromuscular Approaches in the Hip and in the Ankle and Foot for reducing of the Dynamic Knee Valgus in amateur runners	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-10-05	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4fw4f7	<NULL>	20 to 35 years; amateur runner beginners; Up to 1 year of practice; Maximum of 10 km per week; ; Positive Step Down Test.	The volunteers will not be able to present surgical history of the joints of the lower limb, patients with cardiorespiratory and neuromuscular disorders, or any other condition that prevents the participant from performing the proposed tasks, as well as those that do not agree with the terms for participating in the research, provided for in the Informed Consent Form - ICF	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:32
RBR-5tsy7yx	Chambá: an useful medicine in the treatment of high blood pressure?	Not yet recruiting	Intervention	2021-05-27	<NULL>	<NULL>	4682	Evaluation of JP002 in the treatment of individuals with Hypertension: randomized, double-blind, placebo-controlled clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-07-05	Faculdade de Medicina de Ribeirão Preto -USP	Faculdade de Medicina de Ribeirão Preto -USP	https://ensaiosclinicos.gov.br/rg/RBR-5tsy7yx	<NULL>	Men, non-pregnant women, older than 12 years old and less than or equal to 80 years old, diagnosed with Hypertension and on at least monotherapy regimen for this disease.	Pregnant or lactating women; hypertension due to secondary cause; coagulopathies; individuals who use any other herbal medicine during the study; individuals who have a serious adverse reaction to the medication, individuals who request their withdrawal from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-3jwv5kh	Study of Administration of Tranexamic Acid or Placebo on Bleeding in Adult Patients in Surgery for Liver Transplantation	Not yet recruiting	Intervention	2021-05-27	<NULL>	<NULL>	4685	Study on the Administration of Tranexamic Acid or Placebo on the Rate of Perioperative Bleeding in Adult Patients Undergoing Liver Transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital de Clinicas de Porto Alegre	Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3jwv5kh	<NULL>	Only adult ASA III to IV patients, 18 to 70 years old, scheduled for liver transplantation at the Hospital de Clínicas de Porto Alegre, Santa Casa de Porto Alegre and Hospital das Clínicas Faculty of Medicine University of São Paulo.	Patients with a history of acute arterial thrombosis or venous thromboembolism (&lt;1 month), patients with a history of known thrombophilia, Budd-Chiari syndrome, primary biliary cholangitis, primary sclerosing cholangitis, patients with reduced left ventricular function ( ejection fraction &lt;40%), pulmonary hypertension, preoperative pulmonary edema, or severe preoperative hemodynamic changes requiring the use of vasoactive drugs, planned use of tranexamic acid systemically during surgery, hypersensitivity or known allergy to acid tranexamic, history of seizure disorder, patients who have recently suffered a stroke or myocardial infarction (&lt;1 month), patients with subarachnoid hemorrhage in the last 30 days and patients previously undergoing cranial neurosurgery. Patients with chronic dialysis kidney disease or patients in need of a liver-kidney transplant will also be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-63xd92g	Light therapy to prevent Oral Mucositis induced by Radiotherapy in patients with head and neck cancer	Not yet recruiting	Intervention	2021-05-28	<NULL>	<NULL>	4691	Preventive photobiomodulation protocol with light-emitting diode (LED) for Oral Mucositis induced by radiotherapy in patients with head and neck cancer: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Instituto do câncer do ceará	Faculdade de Odontologia, Farmácia e Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-63xd92g	<NULL>	individuals over the age of 18 of both sexes who can read and write; who have normal cognition; who have primary neoplastic lesions in the head and neck region; those who will start treatment with radio chemotherapy	patients previously submitted to radiotherapy and / or chemotherapy of the head and neck; patients using drugs that could interfere with oral mucositis; oral cancer patients; use of poorly adapted mobile prostheses that cause mucosal lesions; presence of limited mouth opening (less than 20 mm); cancer lesions associated with UV light; HIV patients; patients with stomatitis or other lesions of the oral cavity; decompensated diabetes; autoimmune disease or any other disease that may affect the healing mechanisms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:33
RBR-7tgfwmk	Benefits of peppermint oil in upper digestive endoscopies	Not yet recruiting	Intervention	2021-05-29	<NULL>	<NULL>	4701	Use of L-menthol solution as an esophageal antispasmodic in Upper Digestive Endoscopy: pilot project	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tgfwmk	<NULL>	Patients over 18 and under 65;Signed consent form; No known esophageal pathologies; Undergoing diagnostic EDA under conscious sedation	Under 18 or over 65 years old; Refusal to sign the consent form; previously known esophageal pathologies; Undergoing therapeutic examination; Examination performed without sedation or under general anesthesia; Need for the use of scopolamine during the performance of the diagnostic examination before the evaluation for the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:34
RBR-3p8346g	Influence of changes in the genetics of the hunger hormone called ghrelin and the number of meals per day on weight loss, ghrelin in the blood, intestinal flora and body health indicators in women with obesity	Not yet recruiting	Intervention	2021-06-01	<NULL>	<NULL>	4707	Influence of the Ghrelin Gene Polymorphism and meal frequency on body weight loss, ghrelin levels, gut microbiota and metabolic indicators in women with Obesity	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2021-11-25	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3p8346g	<NULL>	Adults with obesity; any race or color; nonmenopausal; no change in body weight recently; did not perform bariatric surgery.	"Use of medication or supplements for weight control that alter the intestinal microbiota; smokers;
drinkers; with complications; cardiac; respiratory; diabetes mellitus; decompensated hypothyroidism; cancer; pregnant women; lactating; illiterate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-2tyxttk	Impact of using video during bed bath simulation on satisfaction and confidence of undergraduate nursing students	Not yet recruiting	Intervention	2021-06-01	<NULL>	<NULL>	4709	Effect of using a bed bathing video performed in the clinical simulation to assess satisfaction and confidence in learning by undergraduate nursing students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2tyxttk	<NULL>	nursing students; properly enrolled; attending the second year of the undergraduate nursing course at UNIFESP; over the age of 18	students who do not wish to be part of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-7p2jfnz	Effects of training with videogame on tremor, arm function and cognition in patients with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2021-06-01	<NULL>	<NULL>	4712	Effects of training with Nintendo Wii on tremor, functionality of upper members and cognition in patients with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-05	Faculdade de Ceilândia - Universidade de Brasília	Faculdade de Ceilândia - Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7p2jfnz	<NULL>	The participation of the study subjects will be conditioned to the following inclusion criteria: age between 50 and 85 years; female and male sex; presence of classic type 1 parkinsonian tremor, according to the consensus statement of the Movement Disorders Society (Deuschl et al., 1993), minimum score of 24 on the Mini Mental State Examination - MEEM; Normal or corrected visual and auditory acuity, allowing interaction with the Nintendo Wii TM system; Score of 1 to 3 on the Hoehn and Yahr Scale; Minimum education of 4 years of formal study.	After selecting all participants who meet the inclusion criteria, those who: Have other associated neurological diseases or conditions that prevent participation in training will be excluded; Have previous experience with the Nintendo Wii TM system; Are attending another specialized rehabilitation program; Score greater than 5 on the Geriatric Depression Scale - GDS - 15 items	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-7y8j2bs	Enriched heparin for the treatment of COVID-19	Not yet recruiting	Intervention	2021-02-10	<NULL>	<NULL>	4716	Inhalational high molecular weight heparin for the treatment of Sars-CoV-2	<NULL>	1-2, randomized-controlled, triple-blind	1-2	<NULL>	<NULL>	<NULL>	2021-06-01	Faculdade de Medicina de Botucatu - UNESP	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7y8j2bs	<NULL>	"Sign and agree to the Informed Consent Form; Both sexes, of any ethnic origin, aged between 18 and 90 years; COVID-19 patients diagnosed by RT-PCR (reverse-transcriptase polymerase chain reaction) or with a strong suspicion of COVID-19 by clinical evaluation through compatible clinical and radiological findings;
4. Time of disease evolution less than 10 days;
5. Radiological diagnosis of pneumonia grade 2 A, with gas exchange ratio&gt; 200 on blood gas analysis (paO2 / pFiO2), characterizing mild hypoxemia;
6. Indication of hospital treatment regime, provided that the period of hospitalization before inclusion is not more than 24 hours;
7. Need for supplemental oxygen therapy (O2) less than 5L / min."	Do not agree with the terms of the study; Moderate or severe respiratory failure requiring admission to the Intensive Care Unit (ICU) with the need for invasive mechanical ventilation or non-invasive ventilation with positive pressure (NIV); Pregnancy or puerperium; People with hematological diseases, coagulation disorders, use of anticoagulants; previous heparin-induced allergy or thrombocytopenia, thrombocytopenia with a count of less than 50.000 platelets / mm3; No diagnostic confirmation of COVID-19 by RT-PCR within 72 hours of inclusion in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-4488twr	Effect of Vascular Occlusion on Muscle Damage caused by Physical Exercise	Not yet recruiting	Intervention	2021-06-02	<NULL>	<NULL>	4718	Effect of Ischemic Preconditioning on Muscle Damage Induced by Resistance Training	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-20	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4488twr	<NULL>	"Male gender;
Age range between 18-34 years;
Do not practice systematic physical exercise in the previous six months;
Absence of diseases / injuries that make physical exercise impossible;
Normal blood pressure values at rest and ankle-arm index (ABI).
Absence of risk factors for thromboembolism;
Do not make chronic use of medication / dietary supplement with anti-inflammatory / antioxidant action"	"Failing to complete the planned interventions;
Use some type of medication with anti-inflammatory properties during the 72 hours after interventions;
Come to exercise during the 72 hours after interventions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:35
RBR-6kkmskk	Safety and efficacy on glaucoma treatment with 3 topical medicationsin one bottle x  medications in separated bottles	Not yet recruiting	Intervention	2021-06-07	<NULL>	<NULL>	4726	Safety and efficacy in the treatment of primary open-angle glaucoma with Triplenex compared to isolated medications	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	centro oftalmologico de minas gerais	centro oftalmologico de minas gerais	https://ensaiosclinicos.gov.br/rg/RBR-6kkmskk	<NULL>	18 years of age minimum; ocular hypertension with intraocular pressure levels greater than or equal to 21 mmHg; carrier of open angle glaucoma presenting intraocular pressure levels greater than or equal to 18 mmHg; reduction of intraocular pressure in relation to baseline values ​​&lt;30%; patients intolerant of current treatment due to ocular surface symptoms; meet the criteria of the control group for at least 3 months;	monoaminoxidase users; patients with asthma or severe chronic obstructive pulmonary disease; patients with sinus bradycardia, atrioventricular block of 2 or 3 degrees not controlled with a pacemaker, decompensated congestive heart failure; patient known to be allergic to any of the components of TRIPLENEX; pregnant patients; patients with any corneal irregularity that hinder the perfect reading of intraocular pressure by Goldman&apos;s tonometer (intra stromal ring, corneal transplant or scars with important corneal thinning); patients undergoing anti-glaucoma surgical procedures in the last 3 months (laser trabeculoplasty; incisional procedures such as trabeculectomy; glaucoma drainage devices, among others)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-399t4g5	Effect of cranial nerve stimulation on inflammation, normalization of the autonomic nervous system and clinical evolution of patients with Covid -19: a pilot study.	Not yet recruiting	Intervention	2021-06-07	<NULL>	<NULL>	4727	"Effect of Vague Nerve Stimulation on inflammation, modulation autonomic cardiac and clinical evolution of patients with Covid-
19: pilot study"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-07	Universidade Nove de Julho	Centro de Neuromulação Spaulding	https://ensaiosclinicos.gov.br/rg/RBR-399t4g5	<NULL>	Patients over 18 years of age; confirmed diagnosis of COVID-19 from moderate to severe; be able to understand the stimulation treatment that will be performed, receiving supplemental oxygen, non-invasive ventilation, but without being intubated	cochlear implant; have uncontrolled diabetes and hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-1044h6fh	Impact of promestriene on hysteroscopy complications in postmenopausal women	Not yet recruiting	Intervention	2021-06-07	<NULL>	<NULL>	4731	Impact of promestriene on the incidence of intraoperative complications in postmenopausal women undergoing surgical hysteroscopy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-07-07	Hospital da Baleia/Fundação Benjamin Guimarães	Hospital da Baleia/Fundação Benjamin Guimarães	https://ensaiosclinicos.gov.br/rg/RBR-1044h6fh	<NULL>	postmenopausal women; with indication of surgical hysteroscopy; patients of the Hospital da Baleia	Patients who refuse to participate, not signing the consent form; Patients who do not make adequate use of promestriene; Previous attempt at surgical hysteroscopy with complication; Patients with a personal history of breast, ovarian or endometrial cancer; Patients already using hormone therapy; Known hypersensitivity to promestriene or any component of the formulation; Exclusion criteria for the promestriene group: patients with other diseases that contraindicates the use of estrogen (unexplained vaginal bleeding, severe active liver disease, coronary heart disease, stroke, dementia, high risk of venous thromboembolic disease, porphyria cutanea tarda, hypertriglyceridemia and patients with whom there is concern about endometriosis reactivation, possibility of migraine worsening or possibility of leiomyoma growth). These patients will be will be allocated in the placebo group without randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:36
RBR-8vvzp26	Study to assess bacterial pneumonia and viral respiratory tract infections in hospitalized older adults in Brazil	Not yet recruiting	Observational	2021-06-09	<NULL>	<NULL>	4741	The epidemiology of S. pneumoniae related community-acquired pneumonia and respiratory syncytial virus in low respiratory tract infection in hospitalized older adults in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-01	Fundação Faculdade Regional de Medicina de São José do Rio Preto	Merck Sharp & Dohme Corp., uma subsidiária da Merck & Co., Inc.	https://ensaiosclinicos.gov.br/rg/RBR-8vvzp26	<NULL>	Aged 60 years old or older at enrollment; Hospitalized patient; Subject with clinical evidence of LRTI at hospital admission or up to 48 hours; Medical chart available for revision and data collection; Consent to take part in the study by signing the ICF. If the subject is not able to consent, formal consent should be collected by the legal responsible before study initiation	"Enrolled in this study within the past 30 days; An individual can present multiple episodes of pneumonia (as a new infection), so he/she can be included multiple times in this study. Those who are re-admitted within 30 days from the previous hospitalization will be excluded, as it would probably be a complication of the initial episode of pneumonia. A re-hospitalization after 30 days of previous hospital discharge will be considered as a new pneumonia infection; Older adult patients with hospital-acquired infection or ventilator-associated infection; Transferred from another hospital or inpatient healthcare facility after already being hospitalized for 48h or more (in this case, it will be considered hospital-acquired
infection); Development of LRTI more than 48 hours after hospital admission (if developed
48 hours after admission, it will be considered as hospital-acquired LRTI); Patients unable or unwilling to provide a urine samples within 48 hours of hospital admission (considering patients transferred from another hospital, this period include the time elapsed since the first hospital admission); Alternative illnesses that explain patient’s signs and symptoms, that excludes LRTI as primary diagnosis; Patient in use of antibiotics in the last 7 days before ICF signature; Patient who does not live in the same municipality as study site"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:37
RBR-2k58f5h	Application of physiotherapy equipment on Back Pain	Not yet recruiting	Intervention	2020-11-26	<NULL>	<NULL>	4754	Application of electrothermalphototerapeutic current in patients with Lumbar Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2k58f5h	<NULL>	female and male gender, aged between 18-80 years; diagnosed with nonspecific low back pain for more than 3 months; with pain numerical greater than 4.	Participants who have performed some surgery in  lumbar region; with irradiated pain; cauda equina syndrome; thermal or sensory alterations; pregnant women; spinal problems; pacemaker; skin lesions and use of medication for relief of low back pain 48 hours before the application; skin diseases; especially at the current site of application; History of tumors or cancer in the last 5 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-2chrm72	Percutaneous technique for hallux valgus correction: is it necessary to fix ?	Not yet recruiting	Intervention	2021-05-31	<NULL>	<NULL>	4755	Percutaneous Chevron-Akin technique for hallux valgus correction: is it necessary to fix the Akin? A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Instituto Prevent Senior	Instituto Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-2chrm72	<NULL>	Patients diagnosed with moderate or severe hallux valgus, with no improvement after six months of conservative treatment and who have agreed and signed the informed consent form.	Patients with neuropathy, skin lesions, previous degenerative injuries to the ankle or previous surgeries on the ankle or foot, less than 16 years old, sequelae of fractures of the tibial pylon, ankle and foot. In addition, patients with collagen disorders, rheumatoid arthritis, seronegative arthritis will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-3gv5cwd	Ultrasound-guided infiltration of hyaluronic acid versus corticosteroid for the treatment of morton&apos;s neuroma	Not yet recruiting	Intervention	2021-05-31	<NULL>	<NULL>	4756	Ultrasound-guided infiltration of hyaluronic acid versus corticosteroid for the treatment of morton&apos;s neuroma: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Instituto Prevent Senior	Instituto Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-3gv5cwd	<NULL>	Patients with a clinical diagnosis of Morton&apos;s Neuroma confirmed by an ultrasound examination, attended at the outpatients of the group&apos;s researchers and signed the informed consent form.	Patients with neuropathy, skin lesions, previous degenerative injuries to the ankle or previous surgeries on the ankle or Achilles tendon, previous allergy to sodium hyaluronate, allergies to avian proteins, less than 16 years of age, sequelae of tibial pylon fractures, ankle and foot. In addition, patients with collagen disorders, rheumatoid arthritis, seronegative arthritis will be excluded. Patients with previous infiltration will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-324wqpv	Evaluation of the effectiveness and safety of a health product.	Not yet recruiting	Intervention	2021-06-28	<NULL>	<NULL>	4764	Double blind controlled clinical study for biological evaluation of Calcium Phosphate and Synthetic Biopolymers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-23	DentsCare Ltda.	DentsCare Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-324wqpv	<NULL>	Healthy patients; older than 20 years and with a maximum age of 60 years; do not present any disease at the moment; not using any medication that may alter or compromise the bone healing response (medication for diabetes, autoimmune dysfunction, prolonged corticosteroid therapy or chemotherapy), they cannot be smokers and if in the case of ex-smokers, they must be at least 6 months without smoking before the study); patient should not report a history of anxiety, mood, eating and / or psychotic disorders that could compromise their participation and collaboration in the study	Age less than 20 years and more than 60 years; pregnant volunteers; drinkers; active smokers; diabetics; osteoporosis patients; participants using medication that can alter or compromise the bone healing response such as prolonged use of corticosteroids and bisphosphonates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-6yv2xry	Effect of anesthetic ankle block, through local infiltration of medications Dexmedetomidine and Ropivacaine, for postoperative pain relief: a study with random selection of patients	Not yet recruiting	Intervention	2021-06-29	<NULL>	<NULL>	4767	Effect of Dexmedetomidine added to Ropivacine on ankle block for postoperative analgesia: randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-08-01	Instituto Prevent Senior	Instituto Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-6yv2xry	<NULL>	Inclusion criteria are: adults undergoing foot surgery (hallux valgus correction, claw toes and tailor&apos;s bunion), of both genders, older than 18 years; having signed and agreed to the voluntary consent form to participate in the study (TCLE); not having a previous allergy or contraindication for the selected anesthetic procedure.	Exclusion criteria are: patients who are allergic to selected and offered anesthetic medications; refusal of the type of anesthetic procedure drawn and offered; anesthetic risk that contraindication is the type of anesthesia drawn and offered; patients with malignant tumors and infections present; patients with mental confusion or disoriented; patients under 18 years of age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-52d3j4d	Efficacy of at-home bleaching with buccal and palatal application of teeth	Not yet recruiting	Intervention	2021-06-29	<NULL>	<NULL>	4768	Efficacy of at-home bleaching technique using the bleaching agent on the buccal and palatal surfaces - randomized clinical trial split-mouth and single-blind	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-05	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-52d3j4d	<NULL>	Age over 15 years; good general and oral health; absence of caries; absence of restorations; absence of endodontic treatment on anterosuperior teeth; upper right and left canine with color A2 or lower according to the value oriented Vita Classical color scale.	Patients who have already had teeth whitening, who are undergoing orthodontic treatment, who have severe discoloration due to tetracycline and fluorosis stains will not be included in the study. In addition, participants with any other pathology that may cause sensitivity (such as recession, dentin exposure or the presence of visible cracks in the teeth), patients with a history of dental hypersensitivity, patients with bruxism, pregnant women, nursing mothers, smokers and patients who are using analgesic or anti-inflammatory drugs that can influence the perception of dental sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:38
RBR-8nfx26	Effect of Inhaled Nitric Oxide for the treatment of COVID-19	Not yet recruiting	Intervention	2020-09-22	<NULL>	<NULL>	4770	Inhaled Nitric Oxide for Treatment of SARS-CoV-2 Infection: An Open-Label, Multicenter, Parallel, Randomized Controlled Trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2021-07-10	Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-8nfx26	<NULL>	"Protocol A
Hospitalized patients with proven or high suspicion of coronavirus infection; signing a consent form and/or assent; older than 10 years. Score clinical 4 (receiving supplemental oxygen).

Protocol B
Non hospitalized patients with proven or high suspicion of coronavirus infection; signing a consent form and/or assent; older than 10 years. Score clinical 2 (at home with limitations)."	"Protocol A
Participant in any other clinical trial of an experimental treatment for COVID-19; pregnancy; clinical contraindication of the attending physician; use of a nitric oxide donor agent, such as nitroglycerin or drugs known to increase methaemoglobin, such as lidocaine, prilocaine, benzocaine or dapsone; heart failure, left ventricular dysfunction; history of hemoptysis. 

Protocol B
Participant in any other clinical trial of an experimental treatment for COVID-19; Pregnancy; clinical contraindication of the attending physician; indication for hospitalization at the time of evaluation; use of a nitric oxide donor agent, such as nitroglycerin or drugs prepared by increasing methemoglobin, such as lidocaine, prilocaine, benzocaine, or dapsone; heart failure, left ventricular dysfunction; hx of hemoptysis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-3t9pkzt	Covidreab study: pulmonary rehabilitation on physical capacity, functional capacity, and quality of life in post-covid-19: randomized, controlled  double-blinded clinical trial	Not yet recruiting	Intervention	2021-07-01	<NULL>	<NULL>	4772	Covidreab study: pulmonary rehabilitation on physical capacity, functional capacity, and quality of life in post-covid-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3t9pkzt	<NULL>	Clinically stable individuals, residing in Manaus must have been diagnosed with COVID-19 by the polymerase chain reaction method (RT-PCR) for SARS-CoV-2, remained hospitalized and had discharged from the hospital. In addition, volunteers must present a pre-hospitalization medical history of clinical stability in the 4 months before hospitalization for COVID-19 and perception of dyspnea II and III by the Medical Research Council (MRC).	Volunteers undergoing pulmonary rehabilitation 6 months before the start of the study, pregnant women, previous medical history of respiratory diseases (COPD, asthma, idiopathic pulmonary fibrosis), arterial O2 saturation (SpO2) ≤ 88% at rest, hypertension uncontrolled, cardiovascular (heart failure, hypertension, transplantation, and surgeries), history of use and abuse of illicit drugs, alcoholics, smokers, pacemakers and/or implantable defibrillators, oncologic, metabolic (diabetes) and decompensated, chronic-degenerative kidneys in progression and osteoarticular and cognitive that prevent the performance of the physical exercise. In addition, individuals who present claustrophobia to the use of the NIV mask for training or performing the cardiopulmonary test will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-76vd5wf	Evaluation of the effect of Brazilian Propolis on mouth Inflammation (Mucositis) in patients undergoing treatment for Head and Neck Cancer	Not yet recruiting	Intervention	2021-07-02	<NULL>	<NULL>	4775	Effects of Brazilian Propolis on Mucositis in patients being treated for Head and Neck Cancer	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade de Franca	Fundação Santa Casa de Misericórdia de Franca	https://ensaiosclinicos.gov.br/rg/RBR-76vd5wf	<NULL>	"Phase 1: Volunteers over 18 years old; in full health;
Phase 2: Volunteers over 18 years old; in head and neck cancer treatment; in radiotherapy and chemotherapy treatment with cisplatin; with the presence of mucositis."	"Phase 1: individuals who have any type of disease, linked or not to cancer; 
Phase 2: individuals in oncology, with chemotherapy other than cisplatin."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-2mh55h7	Evaluation portable devices in diagnosis and follow-up of eye diseases during the COVID-19 pandemic	Not yet recruiting	Intervention	2021-07-06	<NULL>	<NULL>	4776	Use of portable devices in the diagnosis of ocular diseases during the COVID-19 pandemic	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Sociedade Brasileira e Japonesa de Beneficência Santa Cruz / Hospital Santa Cruz	Sociedade Brasileira e Japonesa de Beneficência Santa Cruz / Hospital Santa Cruz	https://ensaiosclinicos.gov.br/rg/RBR-2mh55h7	<NULL>	Both genders; Chronic glaucoma diagnosis; capable of giving informed consent; age between 21 and 80 years old; no cornea abnormalities; capable of; undergoing ocular pressure measurement; reliable Humphrey visual field in at least 3 consecutive examinations	Ocular surgery in previous 6 months; history of corneal surgery; media opacities or active ocular disease that compromises the exam performance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:39
RBR-6gjm5gr	Clinical study comparing a nasal spray and a nasal saline solution in continuous jet in the prevention of the new coronavirus (COVID-19)	Not yet recruiting	Intervention	2021-07-27	<NULL>	<NULL>	4798	Non-inferiority, prospective, phase III, single-center, open, randomized, parallel-group clinical study comparing Carrageenan nasal spray and 0.9% sodium chloride nasal saline in a continuous stream in the prevention of COVID-19	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-08-02	Herbarium Laboratório Botânico	Herbarium Laboratório Botânico	https://ensaiosclinicos.gov.br/rg/RBR-6gjm5gr	<NULL>	Healthy men and women aged between 18 and 60 years; be asymptomatic and present oximetry &gt; 94%, at rest; being a contact and living in the same household as a patient with positive clinical and laboratory diagnosis for coronavirus (SARS-CoV-2), with up to 7 days of clinical manifestations, seen in the emergency department of Hospital Mater Dei; no signs and symptoms of coronavirus-related illnesses (SARS-CoV-2), influenza, or cold in the past 6 months; agree with the study procedures and sign the consent form.	Participants with a history of positive diagnosis for coronavirus (SARS-CoV-2) in the last 6 months; participants already immunized with any type of vaccine for the coronavirus (SARS-CoV-2), even if they received only the first dose; diagnosis of poorly controlled rhinitis or respiratory allergy and/or in crisis, whether acute or chronic; chronic lung diseases in the process of aggravation or in crisis; chronic or obstructive clinical manifestations of the nose: septal deviation, nasal polyposis, chronic sinusitis; recurrent sinusitis (&gt; 3 episodes) in the last 6 months; treatment with antibiotics, systemic or inhaled steroids in the last 4 weeks; breastfeeding and/or pregnancy; coagulation disorders; known or suspected hypersensitivity to the formula of the products under study; severe or decompensated cardiovascular disease, decompensated diabetes mellitus, kidney or liver dysfunction, malignancy or suspected malignancy; any other criteria or clinical history that could compromise the participant&apos;s well-being or interfere with the research results, in the researcher&apos;s opinion (example: chronic diseases).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-9nn3scw	Immunogenicity and safety of heterologous booster vaccination; with the covid-19 recombinant vaccine (AstraZeneca/Fiocruz), covid-19 mRNA vaccine (Pfizer/Wyeth) or covid-19 recombinant vaccine (Janssen), and homologous with inactivated covid-19 adsorbed vaccine (Sinovac/Butantan)	Not yet recruiting	Intervention	2021-07-30	<NULL>	<NULL>	4805	Phase 4, randomized, controlled, single-blind study to assess the immunogenicity and safety of a third dose of heterologous booster with recombinant covid-19 vaccine (AstraZeneca/Fiocruz), covid-19 mRNA vaccine (Pfizer/Wyeth) or vaccine recombinant covid-19 (Janssen) in subjects previously vaccinated against Covid-19 with two doses of Sinovac/Butantan compared to a third homologous booster dose of adsorbed inactivated covid-19 vaccine (Sinovac/Butantan) in adults	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-08-01	Instituto D&apos;Or de Pesquisa e Ensino	Instituto D'Or de Pesquisa e Ensino	https://ensaiosclinicos.gov.br/rg/RBR-9nn3scw	<NULL>	Male or female ≥18 years of age; Subjects are willing and able to comply with the study procedures; Individuals are willing and able to provide informed consent prior to screening; Subjects who received two doses of Sinovac/Butantan vaccine, 182 days (±30 days) prior to inclusion in this study; Female participants are eligible to participate in the study if they are not pregnant, have recently given birth or are breastfeeding	Subjects with fever &gt;37.5 °C (axillary) or any acute illness at baseline (Day 1) or within 3 days prior to randomization; Individuals with a history of COVID-19; Subjects with a history of severe adverse reaction associated with a vaccine or severe allergic reaction (eg, anaphylaxis) to any component of the study vaccines as described in the latest summary of product characteristics for Sinovac/Butantan, Fiocruz/AstraZeneca, Pfizer/Wyeth, Janssen; Individuals with a known bleeding disorder that, in the investigator&apos;s opinion, would contraindicate intramuscular injection; Individuals with any severe or progressive neurological disorder, seizure disorder, or a history of Guillian-Barré syndrome; Subjects who received treatment with immunosuppressive therapy in the last 15 days, including cytotoxic agents or systemic corticosteroids, or planned receipt during the study period; Individuals with autoimmune diseases, with the exception of: Hashimoto&apos;s thyroiditis, vitiligo, psoriasis, lupus discordes and the like, HIV positive individuals and/or being treated for HIV; Individuals who received any other investigational product within the 30 days prior to Day 1 or intend to participate in another clinical study at any time during the course of this study; Subjects who received any other licensed vaccine within 14 days of enrollment in this study or who plan to receive any vaccine within 28 days of vaccination; Subjects who received treatment with Rituximab or any other anti-CD20 monoclonal antibody within 9 months prior to Day 1 or planned during the study period; Administration of intravenous immunoglobulins and/or any blood products within 3 months of inclusion or planned administration during the study period; Individuals with any condition that, in the investigator&apos;s opinion, could interfere with the primary objectives of the study or represent additional risk to the participant; Any other Covid-19 vaccine with the exception of two doses of CoronaVac.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-7fnwdr4	Cerebral stimulation in the treatment of pain due to brachial plexus nerve damage	Not yet recruiting	Intervention	2021-08-04	<NULL>	<NULL>	4811	High-definition Transcranial Direct Current Stimulation in Treatment of Neuropathic Pain After Brachial Plexus Injury: A Randomized Pilot Study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Programa de Pós-Graduação em Neurociência e Comportamento - Universidade Federal da Paraíba	Laboratório de Estudos em Envelhecimento e Neurociências - Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7fnwdr4	<NULL>	"Age between 18 and 64 years;
Score of 4 to 10 points on the Visual Analogue Scale (VAS);
Persistent pain, refractory to clinical treatment for at least 3 months, and who have received adequate pharmacological treatment for pain with an association of antidepressants, gabapentinoid antiepileptics and analgesic opioids for at least 2 months before the start of the study."	"Current pregnancy;
Contraindications for tDCS, including metallic skull implants;
Major ongoing depression, as defined by a baseline score ≥ 29 in the Beck-II Depression Inventory (BDI-II);
Previous history of alcohol or substance abuse in the last 6 months;
Use of carbamazepine in the last 6 months;
Previous history of epilepsy, stroke, moderate to severe head trauma, episodes of unexplained fainting or severe migraine;
History of neurosurgery;
Hypertrophic wounds or scars on the scalp under the placement of the electrodes."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:41
RBR-103qdhn6	Prospective study  of tibial base plate rotation in Total Knee Arthroplasty : Sahin X Akagi &apos;s methods	Not yet recruiting	Intervention	2021-08-09	<NULL>	<NULL>	4820	Randomized clinical trial of Tibial Base Plate Rotation in TKA : Sahin X Akagi	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Departamento de Ortopedia e Traumatologia, Campus São Paulo, Escola Paulista de Medicina, UNIFESP	Departamento de Ortopedia e Traumatologia, Campus São Paulo, Escola Paulista de Medicina, UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-103qdhn6	<NULL>	Male and female between 50 and 80 years; Mild and severe gonarthrosis: Informed consent signed	Reumatological knee deaseses; previous knee surgeries; infection; cognitive problems; age inferior of 50 years or superior of 80 years; knee flexion inferior of 90 degrees; flexion contracture superior of 20 degrees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-6kfptkj	Effect of Strength Training with Blood Flow Restriction on Arterial Occlusion Pressure, Body Composition, Muscle Strength and Localized Muscle Endurance	Not yet recruiting	Intervention	2021-08-09	<NULL>	<NULL>	4821	Effect of Strength Training with Blood Flow Restriction: Physiological, Morphological and Neuromuscular Adaptations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-06	Universidade Federal da Paraíba (UFPB)	Universidade Federal da Paraíba (UFPB)	https://ensaiosclinicos.gov.br/rg/RBR-6kfptkj	<NULL>	be between 18 and 30 years old; have no history of cardiovascular or pulmonary diseases; Ankle Brachial Index (ABI) between 0.91 and 1.30; Body Mass Index - normal BMI (≥18.5 and &lt;24.9 kg / m2); answer negatively to all items of the Physical Activity Readiness Questionnaire / PAR-Q	subjects who present any cardiovascular aggravation during the experiment; musculoskeletal or drop out of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-2mdfgdm	Effect of associated therapies on gingival treatment in type 2 diabetic patients.	Not yet recruiting	Intervention	2021-08-11	<NULL>	<NULL>	4825	Effect of active oxygen and photodynamic therapy on the periodontal treatment of residual pockets in diabetes mellitus patient: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Faculdade de Odontologia de Araçatuba - FOA/UNESP	Faculdade de Odontologia de Araçatuba - FOA/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2mdfgdm	<NULL>	Clinical diagnosis of periodontitis; who have undergone periodontal treatment within a maximum of 3 months with at least 4 ps sites greater than or equal to 4mm with bleeding from probing; patients diagnosed with type 2 diabetes mellitus (HbA1c greater than or equal to 7.0%); have at least 15 teeth, excluding third molars.	Smokers or ex-smokers for more than 5 years; patients with anemia; cancer patient active and history of chemotherapy; history of antibiotic therapy in 6 months; history of anti-inflammatory therapy in the last 6 months; patients with blood disorders; pregnancy; patient in orthodontic treatment, patients who require prophylactic antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-88jm8yk	Study Aimed at Assessing whether the Vaccine is safe, how much the body tolerates and how much the immune system reacts to the LEP-F1 + GLA-SE Vaccine in adult participants in a region where there are many patients with leprosy	Not yet recruiting	Intervention	2021-08-11	<NULL>	<NULL>	4830	"Clinical Trial for the Assessment of Safety, Tolerance and Immune Responses to
Vaccine, for the Prevention of Leprosy, LepVax in Adult Participants"	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2022-01-04	Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos / Fiocruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-88jm8yk	<NULL>	Men and women between 18 years and 55 years of age;For phase 1b, they must be in good general health, confirmed by medical history and physical examination, with negative clinical assessment for leprosy. For phase 2a, the diagnosis of paucibacillary leprosy must be confirmed;Female participants of childbearing potential must test negative on a serum pregnancy test at screening and a urine pregnancy test on study vaccination days (D0, D28, and D56). They must not be breastfeeding and must use at least one method of contraception from the time of study enrollment (Day 0) until 30 days after the last injection if they have sex with men;Screening laboratory tests with normal or non-clinically significant values ​​for: sodium, potassium, AST, ALT, total bilirubin, alkaline phosphatase, creatinine, glucose, total white blood cell count, hemoglobin, and platelet count. Abnormal results may be repeated at the discretion of the Responsible Researcher and/or sub-researchers, and may share doubts with the sponsor&apos;s Scientific Leader and, if necessary, with the DSMB;Negative serological tests for: Anti-HIV 1/2 antibody, hepatitis B surface antigen (HBsAg) and hepatitis C virus antibody (HCV);Normal or non-clinically significant urinalysis as determined by the study physician or designee. Abnormal results may be repeated at the discretion of the Lead Investigator;Must be able to complete the study adverse event diary; Must consent to participate in the study, be able and willing to attend all assessment visits, be accessible by telephone or home visits, and live in the region until the study follow-up is completed	"In phase 1b, history of Mycobacterium leprae infection.History of exposure to experimental products containing GLA-SE.History of active tuberculosis or with documented recurrence.History of previous infection with other non-tuberculous mycobacteria;Participation in another study protocol and/or administration of any study product in the last three months prior to screening.Treatment with immunosuppressive drugs (eg, oral or injectable steroids, such as prednisone; high-dose inhaled steroids) or cytotoxic therapies (eg, chemotherapy or radiotherapy) within six months of screening.Received blood transfusion in the last three months prior to screening.
8. Donated blood products (platelets, whole blood, plasma, etc.) in the last month before screening.Received any vaccine one month prior to screening or planned immunizations during follow-up from D0 to D63 and D154 to D168.History of autoimmune disease or other immunosuppressive causes.History of any other decompensated acute or chronic illness (including cardiovascular, pulmonary, neurological, hepatic, rheumatic, hematological, metabolic or renal disease, uncontrolled hypertension) or use of medications that, in the opinion of the Responsible Investigator, may interfere with safety or immunogenicity of the vaccine.Skin rash, tattoos, or any other dermatological condition that may adversely affect the vaccine injection site or interfere with its evaluation.Body mass index (BMI) ≥ 32.Systemic arterial hypertension (systolic &gt; 150 or diastolic &gt; 95).History of psychiatric illness with current medication use.
16. Alcohol or drug abuse in the last six months prior to screening.Chronic smoker (one pack or more per day).History of previous anaphylaxis or severe allergic reaction to vaccines or unknown allergens.Individuals who do not wish to cooperate with all procedures recommended in the study protocol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:42
RBR-4zdtk9n	Effect of cranial magnetic stimulation on pain and mobility of people infected with human T-cell limphotropic virus type 1: randomized clinical trial	Not yet recruiting	Intervention	2021-08-15	<NULL>	<NULL>	4835	Effect of neuromodulation on pain and functional mobility of people infected with HTLV-1 randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Escola Bahiana de Medicina e Saúde Pública	Faculdade de Medicina da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4zdtk9n	<NULL>	To be included in the protocol, the participant must have: age&gt; 20 years; be a carrier of HTLV-1; be a community walker with or without orthosis; with chronic pain (≥ 6 months) in the lower back and / or lower limbs and ability to sign the written consent form	Participants should be excluded if they have: history of epilepsy, cancer, are pregnant women; have a cardiac pacemaker and / or metallic implant in the brain or skull; if they have used illicit drugs and / or alcohol in the last six months; if they use controlled medications; and if they are being accompanied in an exercise program in the 30 days prior to the intervention by rTMS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-8fpzj7t	Evaluation of the Skin Moisturization Potential of a a Psoriasis cream	Not yet recruiting	Observational	2021-08-17	<NULL>	<NULL>	4841	Evaluation of skin hydration by Corneometry of a health product (skin cream for Psoriasis)Tci01.2021	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-06	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	TCI Laboratório Biotecnológico LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-8fpzj7t	<NULL>	Male and female; Age: 18 to 59 years old; Phototype: I to IV; Whole skin of the area;	Participants who refuse to participate in the study; Skin marks in the experimental area that interfere in the evaluation of possible skin reactions; Active dermatoses (local and disseminated) that may interfere with the results of the study; Pregnant or lactating women; Historic of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines; Volunteers with a history of allergy to the material used in the study; Background of atopy; Participants with a history of allergy to products in the tested category; Immunodeficiency sufferers; Kidney, heart or liver transplantation; Forecast of bathing in the sea, pool or sauna during the study; Use of the following medications for systemic topical use: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-68kh6j	Effects of adding an Electrical Appliance associated with other measures to relieve pain during child labor	Not yet recruiting	Intervention	2020-03-17	<NULL>	<NULL>	4850	Effects of the addition of Transcutaneous Electrical Stimulation to Non-Pharmacological measures of relief during childbirth work: Controlled Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Naiara Toledo Dias	Naiara Toledo Dias	https://ensaiosclinicos.gov.br/rg/RBR-68kh6j	<NULL>	inclusion criteria:  pregnant women in active labor; low-risk pregnancies; women with a gestational age of 37-42 weeks; gestation with a single fetus and this one in the cephalic position.	exclusion criteria will be considered:  having a wound or inflammation in the cutaneous areas of application of the TENS electrodes;  presence of a pacemaker; inability to understand verbal commands.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-8jcqy7c	Pain Control Associated with Carboxytherapy in Cellulite Patients	Not yet recruiting	Intervention	2021-08-25	<NULL>	<NULL>	4851	Pain Management associated with the application of Carboxytherapy in patients with Cellulite: randomized controlled trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-06-30	UFSCar_Universidade Federal de São Carlos	UFSCar_Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8jcqy7c	<NULL>	Women; age group between 18 and 49 years; body mass index from 18.5 to 39.9 kg / m²; no previous experience with carboxytherapy; with moderate or severe cellulitis in the gluteal region;.	Pregnant women; lactating women; in the post-menopausal period or amenorrhea; metabolic or autoimmune disorders; history of epilepsy; the presence of malignant or benign tumors; using diuretics; diagnosis of oncological, cardiac and autoimmune pathologies;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:43
RBR-4mzm22c	Mindfulness and self-compassion online to reduce stress and improve quality of life at work	Not yet recruiting	Intervention	2021-09-09	<NULL>	<NULL>	4871	Mental health at work: Mindfulness and Self-compassion online to reduce stress and improve the quality of life at work	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4mzm22c	<NULL>	age between 18 and 65 years; availability to participate in the therapeutic schedule; knowing how to read and write; make use of the whatsapp app and the Zoom or Google Meet app; have access to the internet; be willing to be randomized	less than 6 months of work in current job; use of drugs that modulate the activity of the Central Nervous System; being in psychological counseling during the intervention period; have adopted Mindfulness practices in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-7s22c75	Effect of manual therapy associated with neck muscle exercise program and pain education in patients with migraine – a 3-Armed randomized clinical trial	Not yet recruiting	Intervention	2020-12-07	<NULL>	<NULL>	4872	Effect of manual therapy associated with neck muscle exercise program and pain education in patients with migraine – a 3-Armed randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7s22c75	<NULL>	Inclusion criteria: individuals of both sexes, aged between 18 and 55 years, diagnosed with migraine according to the 3rd edition of the International Classification of Headache Disorders, with at least 3 days of migraine per month, in the last month.	other concomitant primary / secondary headaches, including tension-type and cervicogenic headache; history of  facial or neck trauma; history of cervical disc herniation or cervical osteoarthritis; any systemic degenerative disease (for example: rheumatoid arthritis and lupus erythematosus); pregnancy; physiotherapy treatment for craniocervical dysfunction in the previous year; and / or who has started a new pharmacological treatment for the disease in the last three months prior to the screening of this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:44
RBR-10pcsymv	Primary Sarcopenia and Dietary Inflammatory Index	Not yet recruiting	Observational	2021-09-10	<NULL>	<NULL>	4878	Nutritional Quality, Dietary Inflammatory Index Assessment and Body Composition Parameters in Elderly	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10pcsymv	<NULL>	Elderly men and women; wandering or with minimally reduced motility; who has not undergone any surgical intervention in the last 6 months; minimum education of 4 years; with the signing of the Free and Informed Consent Form.	Individuals under the age of 60; Bedridden or wheelchair users; Neurological disease carriers; Education less than 4 years; People with catabolic diseases (eg cancer, all types of neoplasms).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-5d758t9	A Clinical Study for Safety and Immunogenicity Increment after Extra Dose with Chadox1-S/NCOV-19 or third dose of Coronavac in previously Vaccinated Elderly subjects	Not yet recruiting	Intervention	2021-09-15	<NULL>	<NULL>	4889	A Randomized, Patient-Single-Blind Phase IV Clinical Study for Assessing the Safety and Laboratory Immunogenicity Increment after Vaccine Booster with Chadox1-S/NCOV-19 or third dose of Coronavac in previously Vaccinated Elderly subjects	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-09-18	Instituto do Câncer Brasil (unidade Ribeirão Preto)	Instituto do Câncer Brasil (unidade Ribeirão Preto)	https://ensaiosclinicos.gov.br/rg/RBR-5d758t9	<NULL>	Male or female participants; aged 60 years or older; previously vaccinated with CoronaVac; Have previously received 2 doses of CoronaVac, as per the national immunization plan; the second dose administered at least 30 days ago.	Have had Covid-19 after the start of the vaccination schedule with CoronaVac; Symptoms of infection of any organ or etiology in the last 30 days, as per investigator’s judgment; Have had contact with an individual diagnosed with COVID-19 in the work or home environment in the last 10 days;Subjects with AIDS, severe immunosuppression or patients with a severe disease, as per investigator’s judgment.Have a Karnofsky Performance status below or lower than 70 (Attachment A). Known allergy to the components of the vaccines used in the study. Participation in another clinical study in less than 1 year (unless participation is justifiable as per the principal investigator).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-8hhzfv9	"Efeitos da suplementação de arginina e beterraba desidratada na
função vasos sanguíneos de obrigação com Doença Pulmonar Obstrutiva Crônica relacionada à
pulmonar pulmonar"	Not yet recruiting	Intervention	2021-09-16	<NULL>	<NULL>	4890	"Effects of arginine supplementation and dehydrated beet consumption on
endothelial function of individuals with Chronic Obstructive Pulmonary Disease undergoing
pulmonary rehabilitation"	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2021-10-03	Federal University of Health Sciences of Porto Alegre	Pereira Filho Pavilion at the Santa Casa de Misericordia of Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8hhzfv9	<NULL>	Individuals of both sexes, age equal to or greater than 40 years, chronic obstructive pulmonary disease with moderate to very severe expiratory flow obstruction, clinical stability in the month prior to the study protocol	Food allergy to beet, strawberry flavoring or any other component of supplementation, current smoking, presence of associated diseases that make it impossible to carry out any of the evaluations, as osteoarthritis, serious cardiovascular diseases, severe neurological conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-6gtzg4	The use of Electrical Current for Pelvic Floor Muscles in Stress Urinary Loss: a study with cost evaluation	Not yet recruiting	Intervention	2019-11-19	<NULL>	<NULL>	4891	Intravaginal Electrostimulation associated with Pelvic Floor Muscle training protocol for women with Stress Urinary Incontinence: a randomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6gtzg4	<NULL>	Being a woman by biological sex; 18 years of age or older; stress urinary incontinence, which will be determined by the affirmative answer to the following question from the King&apos;s Health Questionnaire: Did you lose your urine unintentionally associated with coughing, sneezing, exercising or weight lifting in the last month ?.	Participants with latex allergy; with vaginal or urinary tract infection; be a virgin; being in the gestational period or after immediate delivery or neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-2j4j5gr	Evaluation of irritability and sensitization of cream for Psoriasis through the Contact Test	Not yet recruiting	Observational	2021-09-16	<NULL>	<NULL>	4895	Assessment of primary skin irritability, accumulation and awareness  of a health product (moisturizing cream for Psoriasis) through the Patch Test	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-27	TCI BIOTECNOLOGIA LTDA	TCI BIOTECNOLOGIA LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2j4j5gr	<NULL>	Male and female; Age: 18 to 59 years; Phototype: I to IV; Whole skin of the area;	Participants who refuse to participate in the study; Skin marks in the experimental area that interfere in the evaluation of possible skin reactions; Active dermatoses (local and disseminated) that may interfere with the results of the study; Pregnant or lactating women; Historic of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medicines; Volunteers with a history of allergy to the material used in the study; Background of atopy; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; Discharges; History of pathologies aggravated or triggered by ultraviolet radiation; Immunodeficiency sufferers; Kidney, heart or liver transplantation; Forecast of intense sun exposure or tanning session during the period of  the study; Forecast of bathing in the sea, pool or sauna during the study; Participants who practice water sports; Use of the following medications for systemic topical use: immunosuppressants, antihistamines, non-hormonal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Treatment with acidic vitamin A and / or its derivatives orally or topically up to 01 month before the beginning of the study; Vaccination forecast during the study or up to 03 weeks before the study; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-744x3tq	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Observational	2021-09-16	<NULL>	<NULL>	4896	Evaluation of gynecological and dermatological acceptability of health products under normal conditions of use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-22	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Avenca Indústria Cosmética Eireli -EPP	https://ensaiosclinicos.gov.br/rg/RBR-744x3tq	<NULL>	Women; Age: 18 to 59 years; Phototype: I to IV; Whole skin of the region; Occasional user of category products	"Skin marks in the experimental area that interfere in the evaluation of possible
reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Background of atopy; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; Discharges; Immunodeficiency patients; Kidney, heart or liver transplantation;
 Active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus,
atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study .; Any condition not mentioned above that, in the investigator&apos;s opinion, may
compromise the evaluation of the study.
Note: the participants included are instructed not to change their diet, routine
exercises and contraceptive method. Also, not to use products of the same category
of the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-5hm95cw	Effect of mobile app on Self-efficacy and prevention of breastfeeding difficulties.	Not yet recruiting	Intervention	2021-09-17	<NULL>	<NULL>	4897	Effect of mobile app on breastfeeding self-efficacy and prevention of breastfeeding complications: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-16	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-5hm95cw	<NULL>	Postpartum women admitted to the maternity room together with their baby; over 18 years of age; literate; who have a smartphone; and who express an interest in breastfeeding.	Women unable to breastfeed for clinical reasons (cases of HIV, cytomegalovirus and/or HTLV), who gave birth to multiple babies, who had a premature birth (&lt;37 weeks) or with a history of hospitalization of the newborn in the ICU.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:45
RBR-7kv6z29	The effects of Transcranial Photobiomodulation in women with fibromyalgia	Not yet recruiting	Intervention	2021-09-20	<NULL>	<NULL>	4903	The effects of transcranial photobiomodulation on clinical conditions and biochemical markers in women with fibromyalgia: a randomized controlled double-blind clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-30	<NULL>	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7kv6z29	<NULL>	Women diagnosed with Fibromyalgia; residing in the Greater Florianópolis-SC; aged from 18 years; who are undergoing pharmacological treatment for Fibromyalgia.	Women with diseases that can be stimulated by light; with immunodepressive diseases; with oncological diseases; with infectious diseases or in a febrile state; epileptics; pregnant women; lactating women; women with symptoms and/or confirmation of COVID-19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-2vw77q	Vamos active life-improving health program	Not yet recruiting	Intervention	2019-09-20	<NULL>	<NULL>	4908	Vamos active life-improving health program	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2vw77q	<NULL>	"For online training, higher-level health professionals; working in basic health units registered in the national register of health establishments in the state of Santa Catarina

For the VAMOS Program, registered in the public health system; physically inactive or overweight; unhealthy eating; with or without chronic non-communicable diseases; diabetes, hypertension"	"For online training, do not have a college degree; work in another health sector other than the basic health unit.

For the VAMOS Program, not being registered in the basic health unit; participate in another group to promote physical activity or healthy eating; physically unable to participate in face-to-face meetings; not having access to a computer or internet; not accepting to participate in the study; not agree to sign the free and informed consent form"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-8gfdkg4	Compare helmet use during respirator use in patients with COVID	Not yet recruiting	Intervention	2021-08-12	<NULL>	<NULL>	4910	Comparison between the effectiveness of the Helmet interface through flow meters versus the mechanical fan for non-invasive ventilation in patients with Covid 19. Controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-24	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8gfdkg4	<NULL>	"Individuals over the age of 18 years with type I respiratory failure with a suspected or confirmed diagnosis of pneumonia caused by COVID-19 who meet all of the following criteria: Adequate level of consciousness, In oxygen therapy with FiO2 ranging from 45% to 81%, with worsening oxygen flow.
 PaO2 / FIO2 &lt;200 mmHg, PaCO2 equal to or less than 50 mmHg, Peripheral oxygen saturation (SpO2) &lt;93% with an offer greater than 6 l/min, Relative contraindication of severe H;  Hemodynamic stability"	"Patients who do not meet the inclusion criteria, who exhibit any absolute contraindication to the use of non-invasive mechanical ventilation and/or who exhibit the following conditions: Previous diagnosis of chronic obstructive pulmonary disease (COPD) with chronic CO2 retention or with its clinical characteristics according to the II Brazilian Consensus on Chronic Obstructive Pulmonary Disease of 2004,
Tracheostomy, patients with proportional therapy criteria (palliatives), patients in circulatory shock, hypoxemia not related to viral pneumonia, patients with severe signs of hypoxemia: the central cyanosis; the lowered level of consciousness or severe psychomotor agitation; the FR &gt; 35 and SpO2 &lt; 80%."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-634ymd5	Understanding Plasmodium falciparum malaria in the Amazon: implications for the national malaria control program	Not yet recruiting	Observational	2021-09-23	<NULL>	<NULL>	4912	Clinical and molecular epidemiology of Plasmodium falciparum malaria in the Brazilian Amazon basin: implications for the national malaria control program	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-10-18	Instituto Nacional de Infectologia Evandro Chagas	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-634ymd5	<NULL>	"Arm I
Inclusion criteria
• Male or women, &gt; 18 years old;
• Acute malaria not complicated by P. falciparum confirmed by thick drop with asexual forms of P. falciparum;
• Parasitic density between 500-100,000 / uL of blood at the time of screening;
• Axillary &gt; 37.5 ° C or history of fever in the last 24 hours;
• Informed written consent;
• Ability to swallow oral medication;
• Willingness and ability to meet the study schedule for the duration of the study.

Arm II:
Inclusion criteria
Man or woman, regardless of age;
Symptomatic malaria falciparum confirmed by (i) positive thick gout with asexual forms of P. falciparum; or (ii) rapid test (RDT) based on LDH, or by (iii) polymerase chain reaction (PCR), HRP2-based AND (iv) HRP2 based RDT;
Axillary temperature &gt; 37.5 °C or history of fever in the last 24 hours;
Informed consent in writing;
Ability and willingness to comply with the study protocols (for the duration of the study and meet the study visit schedule."	"Arm I
Exclusion criteria
• Presence of general signs of danger / complicated falciparum malaria, according to who 2015 definitions;
• Hematocrit &lt;25% or hemoglobin &lt;8 g/dL at screening;
• Mixed infection or mono-infection with another Plasmodium species detected by microscopy;
• Presence of febrile conditions due to diseases other than malaria (measles, acute infection of the lower respiratory tract, severe diarrhea with dehydration);
• Presence of known underlying chronic or serious diseases (e.g.: heart, kidney, liver, HIV/AIDS) diseases
• For women of childbearing age [18-45 years]: positive pregnancy test or breastfeeding;
• Receipt of antimalarial drugs in the previous 48 hours;
• History of known allergy or contraindication to ASMQ;
• Unable to perform the pregnancy test;
• Previous splenectomy;

Arm II
Exclusion criteria
Have been included in the study previously (Arm II);
Have not been tested with HRP2-based RDT;
Refuse the collection of the biological samples."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-6jts634	Study of a product containing Phtalox® for the prevention and control of Pyorrhea	Not yet recruiting	Intervention	2021-09-24	<NULL>	<NULL>	4913	Clinical study of a formulation containing Phtalox® for the prevention and control of Periodontal Disease	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6jts634	<NULL>	Individuals of both sexes; no history of systemic complications for more than 6 months; no recent drug history; systemically healthy; PD patients.	Individuals who do not wish to complete the treatment protocol; individuals with healthy periodontium; pregnancy; lactation; drug abuse; individuals with systemic changes; individuals who have used antibiotics in the past 3 months; individuals with systemic diseases requiring antibiotic prophylaxis prior to periodontal therapy; immunosuppressed individuals.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-3zvc3s	Evaluation of Gabapentin as a drug that helps in postoperative pain management of Knee Surgery	Not yet recruiting	Intervention	2019-08-21	<NULL>	<NULL>	4914	Gabapentin as an adjuvant in the management of pain in the postoperative of Anterior Cruciate Ligament surgeries: a double, blind, randomized and controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Instituto de Ortopedia e Traumatologia de Joinville	Instituto de Ortopedia e Traumatologia de Joinville	https://ensaiosclinicos.gov.br/rg/RBR-3zvc3s	<NULL>	Patients of both genders, aged between 18 and 50 years; with single lesion of the unilateral Anterior Cruciate Ligament; who undergo surgical treatment of a single lesion of the Anterior Cruciate Ligament.	Patients who present allergy to Gabapentin, Tramadol, Dipyrone or Nimesulide (prior or during the study); Renal or Hepatic Insufficiency; patients with recent previous use of anticonvulsants, opioids, or antidepressant agents; or who are being treated with cimetidine or antacids for any reason; associated chondral lesion; injury of another associated ligament; associated meniscal injury; diabetes mellitus; fibromyalgia; chronic pain; depressive disorder, bipolar disorder, generalized anxiety disorder; history of illegal substance use or alcohol abuse; non-literate patients and those who do not agree to sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-5xp96cq	Respiratory Treatment Protocol after Covid-19	Not yet recruiting	Intervention	2021-09-28	<NULL>	<NULL>	4921	Respiratory Muscle Intervention Protocol in Subjects After Covid-19 Infection	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-15	Universidade Metodista de Piracicaba	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5xp96cq	<NULL>	Volunteers after COVID-19; no physical therapy treatment after hospital discharge; both sexes; hospitalized for 15 days or more; with respiratory and motor sequelae; able to carry out the proposed assessments and training	Volunteers with no hospitalization history; decompensated heart diseases; musculoskeletal and/or neuromuscular changes; with three consecutive absences in treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-5khzxz	Effects of cardiorespiratory, resistance and core training on neuromuscular variables, pain perception, stress, and biochemical markers in adults with low back pain: a randomized clinical trial	Not yet recruiting	Intervention	2020-09-24	<NULL>	<NULL>	4923	Cardiorespiratory, Counter-Resistance and Core Training in adults with low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5khzxz	<NULL>	Have a perception of low back pain equal to or greater than 4 on the visual analog pain scale VAS; have medical clearance.	Are undergoing or have undergone less than 4 months of physiotherapeutic treatment involving strength and / or flexibility training; the pain is caused by trauma; who have high blood pressure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-4qmypqq	Effectiveness of HCV treatment by non-specialists (general practicioners or family-doctors) compared to specialists (hepatologists, gastroenterologists or infectious disease doctors) in the brazilian public health system	Not yet recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4929	Randomized open-label and non-inferiority clinical trial to evaluate treatment retention, safety and cost-effectiveness of simplified and decentralized HCV treament compared to standard-of-care in the brazilian public health system	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2021-12-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4qmypqq	<NULL>	Age between18 and 79 years-old; presence of chronic hepatitis C	Pregnancy; HBV co-infection; HIV co-infection; use of medications with potential interaction with SOF/VEL; presence of acute disease, neoplasm, solid organ transplant or use of immunossupressor; presence of clinical signs of decompensated cirrhosis; refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-7rtcpp6	Can Strength Training combined with Light Therapy reduce Insulin Resistance?	Not yet recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4931	Strength Training and Photobiomodulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-28	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7rtcpp6	<NULL>	"Be male or female;
Sign the informed consent form after reading and understanding it;
BMI &gt; 25 kg/m2;
Be between 18 and 60 years old;
Have stable body mass (variation less than 3 kg) in the last 3 months;
Not being diagnosed, and not showing signs and symptoms of cardiovascular, metabolic or kidney disease from medical history;
Being insufficiently active (&gt;150 min/week of moderate to intense physical activity) based on a questionnaire;
Being able to perform moderate to intense physical activity based on a questionnaire."	"Being diabetic, or diagnosed with another metabolic disease;
Being diagnosed with cardiovascular or kidney disease;
Perform 150 min or more of moderate-intense physical activity per week;
Not being able to perform physical exercise of moderate to intense intensity;
Present signs or symptoms of metabolic, cardiovascular or renal disease;
Make use of drugs with an effect on the metabolism, anti-inflammatory or anabolic steroids;
Present musculoskeletal injury that prevents the performance of tests and strength training;
Be pregnant;
Have fasting blood glucose &gt;125 mg/dl;
Present blood glucose &gt;199 mg/dl at 120 min of the oral glucose tolerance test;
Missing 10% or more of training sessions."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-2c96zr3	Clinical and laboratorial evaluation of digitally fabricated dentures	Not yet recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4932	Mechanical, biological and microbiological properties of milled or printed dentures: an in vitro and clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2c96zr3	<NULL>	Regular use of the bimaxillary complete dentures for at least one year, need to replace complete dentures, good general health, absence of intraoral pathology or lesions, absence of changes in the perioral musculature	Health problems that make rehabilitative treatment unfeasible and to return appointments, severely reabsorbed ridge, palatine torus to need surgery remotion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-7s8bw6m	The importance of text messaging and video applications on cell phones in the transfer of information on oral health education to mother and child	Not yet recruiting	Intervention	2021-10-01	<NULL>	<NULL>	4937	Influence of digital media in oral health education in the mother-child binomial: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-09	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7s8bw6m	<NULL>	Will be included in the study individuals (mother and child) with good general health and responsible (mother) have a smartphone with Whatsapp	Individuals (mother and child) showing learning difficulties will be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-524ys9	The effect of a discontinuation protocol on the use of clonazepam in the elderly	Not yet recruiting	Intervention	2019-06-11	<NULL>	<NULL>	4938	Effectiveness of a protocol for the deprescription of clonazepam use in the elderly: single-arm intervention trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-30	Universidade Federal de São João del-Rei (UFSJ)	Universidade Federal de São João del-Rei (UFSJ)	https://ensaiosclinicos.gov.br/rg/RBR-524ys9	<NULL>	"Elderly patients in clinical use of clonazepam will be included for anxiety and insomnia;
administered daily for at least three months; which were attended at the Basic Health Units in question."	"Epileptic patients will be excluded; patients in psychiatric treatment and / or with a history of psychosis;
patients dependent on alcohol and illicit drugs;
patients who are not cognitively competent and do not have a caregiver, according to the mini mental state examination;
other unforeseen situations will be analyzed, in an individualized way, by the doctor of the health unit"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-6vf3mgg	Effect of light physical exercise with mild Restriction of blood flow on the muscle strength of the arms in the elderly	Not yet recruiting	Intervention	2021-10-04	<NULL>	<NULL>	4939	Effect of low intensity resistance training with partial blood flow Restriction on upper limb muscle strength in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Estadual de Ciências da Saúde de Alagoas	Universidade Estadual de Ciências da Saúde de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-6vf3mgg	<NULL>	Seniors; both sexes; Ages between 60 and 79 years	Functional disability; moderate to severe cognitive deficit; medical restriction to physical exercise; strength training for more than 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:47
RBR-3czz68	Minimally invasive versus convencional surgery for the treatment of displaced fractures of the clavicle shaft: a randomized multicentric pragmatic clinical trial	Not yet recruiting	Intervention	2020-11-03	<NULL>	<NULL>	4942	MIO vs ORIF in the treatment of displaced fractures of the clavicle shaft: a randomized multicentric pragmatic clinical trial	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2021-07-01	Adriano Fernando Mendes Junior	Adriano Fernando Mendes Junior	https://ensaiosclinicos.gov.br/rg/RBR-3czz68	<NULL>	healthy volunteers; both genders; age over 18 years; with displaced fractures of the shaft of the clavicle type 2B according to Robinson&apos;s classification; evolution of up to 21 days.	patients with open fractures of the clavicle; with associated vascular or nerve injuries; with fractures of the shaft of the clavicle with joint extension; with concomitant fractures or dislocations in the shoulder girdle; with other fractures in the same upper limb; with a history of previous fractures in the clavicle; with a history of previous trauma to the shoulder girdle; with pathological fractures; patients with metabolic diseases; patients with congenital deformities on the same limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-103zbhkj	Educational technology on breast cancer prevention for healthcare professionals	Not yet recruiting	Intervention	2021-10-07	<NULL>	<NULL>	4948	Effectiveness of educational technology on breast cancer prevention for healthcare professionals: pragmatic randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-10	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-103zbhkj	<NULL>	Have one year of service in Basic Health Units; acting in assistance as the main professional activity; be a doctor, nurse, social worker, physical education professional or teacher, pharmacist, physiotherapist, speech therapist, physician, nutritionist, dentist, psychologist and occupational therapist.	Professionals on leave for any reason during the period of application of the research; do not serve women; do not have access to a device with an Internet connection; those who report not having time available; they gave up participating in the research after starting data collection; for some reason, they were absent from one of the data collection stages, demonstrating disinterest in continuing their participation, and refusing to continue in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-9yffqb7	Effect of analgesic and anti-inflammatory current on muscle strengthening in patients with knee arthrosis. Blind randomized clinical trial	Not yet recruiting	Intervention	2021-10-08	<NULL>	<NULL>	4951	Additional effect of diadynamic currents in a strengthening program muscle in patients with knee arthrosis. Blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	FMRP - USP (Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo)	UNISALESIANO LINS	https://ensaiosclinicos.gov.br/rg/RBR-9yffqb7	<NULL>	Patient with knee osteoarthritis (Kellgren and Lawrence classification grades II and III); Age between 50 and 70 years and; Pain equal to or greater than 3 at rest and / or equal to or greater than 5 after a 6-minute walk test; Whether a bilateral OA will be considered the side most affected.	Occurrence of great discomfort after performing the exercises and / or applying electrical stimulation; Failure to perform the exercises during two consecutive sessions; Also excluded are patients who for any reason no longer wish to participate in the research or have any of the criteria for non-inclusion in the period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-6wryhb9	Effects of different methods to treat myofascial pain	Not yet recruiting	Intervention	2021-10-11	<NULL>	<NULL>	4966	Effects of different methods to treat myofascial trigger points: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-04	Universidade Estadual Paulista, Instituto de Biociências	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6wryhb9	<NULL>	Both genders; between 18 to 40 years old; presence of trigger points in the musculature; physically active; signed the statement of informed consent	Body Mass Index (BMI) above 30; have used analgesic, anti-inflammatory, anticoagulant, muscle relaxant or antipyretic medications up to 24 hours before; needle phobia; pregnant women; performed strenuous exercises or used stimulants 24 hours before; sensitivity or mental disorders diagnosed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-3r92s4x	Effects of weight training, walking, and HIIT on health outcomes of sedentary women who are overweight or obese	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4969	Effects of weight training, walking and high intensity interval training on body composition, anthropometric measures, lipid profile, quality of life and other outcomes in sedentary women with overweight or obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP/USP)	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP/USP)	https://ensaiosclinicos.gov.br/rg/RBR-3r92s4x	<NULL>	Sedentary women, i.e., who have not practiced any type of physical exercise in the last 12 months for a period longer than 30 minutes per week; living in Uberaba, MG; aged between 35 and 45 years; BMI above 25 kg/m2; answering &quot;no&quot; to all items of the Physical Activity Readiness Questionnaire (PAR-Q); ability to walk without the aid of any devices	Current use of appetite suppressing or appetite-stimulating drugs; chronic conditions such as hypertension, diabetes, asthma, COPD; current smoking; being pregnant; weight loss or gain of more than 10% in the last six months, for any reason; treatment for cancer; any other conditions not provided for in the present study protocol that, in the opinion of the investigators, would adversely affect the conduct of the study and/or the safety of the participant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-4dfxtmt	Effect of residency training on health and functionality in the elderly	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4970	The effectiveness of home based physical training on variables related to health and functional capacity of the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-13	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4dfxtmt	<NULL>	seniors able to practice physical activity; over 60 years old; able to answer the study questionnaires and perform the proposed tests; have internet access	Elderly who have or acquire diseases and/or physical-motor and/or intellectual problems and symptoms that make it impossible to apply the questionnaires and/or perform evaluation tests and physical activities; seniors who do not attend at least 75% of classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-69zhsxr	"Effect of breathing exercises in patients with pulmonary diseases due to
non-tuberculous mycobacteria"	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4971	"Effect of respiratory physiotherapy in patients with pulmonary diseases due to
non-tuberculous mycobacteria"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	UFCSPA - Universidade de Ciências da Saúde de Porto Alegre	Hospital Sanatório Partenon - Secretaria Estadual da Saúde do RS	https://ensaiosclinicos.gov.br/rg/RBR-69zhsxr	<NULL>	Patients at the Tuberculosis / MNT Outpatient Clinic of the Hospital Sanatório Partenon of the State Health Department; older than 18 years; who are able to carry out the exercises alone; using smartphones with Internet access	Recent history of hemoptysis; undergoing regular physical therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-9v52jkd	Influence of body mass on the performance of tests that assess cognition	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4972	Influence of the quantity of body mass involved in the exercise on the performance of executive functions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Faculdade de Educação Física e Dança (FEFD) da Universidade Federal de Goiás (UFG)	Faculdade de Educação Física e Dança (FEFD) da Universidade Federal de Goiás (UFG)	https://ensaiosclinicos.gov.br/rg/RBR-9v52jkd	<NULL>	Be literate (because there is a need for participants to answer questionnaires)	women who are pregnant and participants who have any contraindication for performing physical activity, verified by applying the Physical Activity Readiness Questionnaire/PAR-Q and using psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-67c7n8g	The Effects of Audiovisual Neurostimulation in women with Fibromyalgia	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4973	The Effects of audiovisual neurostimulation on Pain, quality of life, brain activity and inflammatory biochemical markers in women with Fibromyalgia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-11	Universidade do Sul de Santa Catarina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-67c7n8g	<NULL>	Women with a clinical diagnosis of FM; living in the greater Florianópolis SC; aged between 18 and 80 years and undergoing pharmacological treatment.	Women with diseases that can be stimulated by light; with immunodepressive diseases; with oncological diseases; with infectious diseases or in a febrile state, epileptics; pregnant women; lactating women; women with symptoms or confirmation of COVID-19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3xzcdky	The use of Cellular Proteins as Enhancers of Bone Formation in Bone Grafting.	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4975	Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting.	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2021-09-30	Pontifícia Universidade Católica do RIo Grande do Sul	Universidade Católica de Leuven	https://ensaiosclinicos.gov.br/rg/RBR-3xzcdky	<NULL>	Patients at least 35 years-old or older, presenting highly atrophic fully edentulous maxilla (residual alveolar bone height &lt;5 mm), requiring bilateral maxillary sinus augmentation and full mouth implant-supported rehabilitation; having teeth extraction at least 8 weeks prior to bone augmentation.	Smokers (more than 10 cigarettes a day), with a history of use or current use of illicit drugs and/or alcohol; patients with metabolic/systemic diseases that lead to impaired tissue healing (eg, decompensated diabetes, leukocyte or clotting disorders, immunosuppression); hx of previous radiotherapy in the head or neck region; receptors for bisphosphonate-based or steroid therapies; intolerant to general and/or local anesthesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-2nvbtvy	Effect of respiratory physiotherapy on the thoracoabdominal synchrony of premature newborn	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4976	Effect of respiratory physiotherapy on the thoracoabdominal synchrony of premature newborn - controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-20	Maternidade Instituto de Saúde Elpídio de Almeida- ISEA	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2nvbtvy	<NULL>	"RNPT; Who are in physiotherapeutic follow-up; indications for bronchial hygiene maneuvers in the presence of auscultation and/or mechanical ventilator charts showing changes suggestive of secretion; Only PTNB that are suitable for aspiration with a 6Fr gauge probe; Mothers aged 18 years and over; Only RNPT that are capable of aspiration with a 6Fr gauge probe.
·       Mothers aged 18 or over."	Present organic and structural changes, involving: chest deformities, necrotizing enterocolitis, skin lesion on the chest, hyperthermia, hypothermia, abdominal pathologies, congenital diaphragmatic hernia and the presence of a chest tube; PTNBs who do not complete any stage of the research procedure will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3v27w3s	Effects of regular, supervised weight-bearing exercise on muscle strength, control of glucose, triglyceride and cholesterol values and how this type of exercise relates to the amount of the hormone irisin in women with Type 2 Diabetes who have stopped menstruating of more than one year	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4978	Effects of Supervised Resistance Training on Muscle Strength, Metabolic Control, Quality of Life and its relation with Irisin in Postmenopausal Type 2 Diabetic women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Faculdade de Ciências Médicas de Pernambuco	PPGCS/UPE - Programa de Pós-Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3v27w3s	<NULL>	Female patients; in the postmenopausal period; diagnosed with type 2 diabetes mellitus; with variations in glycosylated hemoglobin levels less than or equal to 11%; and are classified as being sedentary or irregularly active according to the International Physical Activity Questionnaire.	Past coronary or cerebrovascular event; carriers of chronic kidney disease with an estimated glomerular filtration rate less than or equal to 30 ml / min; orthopedic limitation for physical exercise; proliferative diabetic retinopathy; disabling diabetic neuropathy; NYHA class III or IV heart failure; established liver disease Child B or C classification; decompensated thyroid disease; malignant neoplasm, except for basal cell carcinoma; in coronary, carotid or peripheral arterial revascularization schedule; documented myocardial ischemia; classified as active or very active by the International Physical Activity Questionnaire; participation in any training program using weights in the last 6 months; and with adherence to the systematic resistance training protocol below 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-8bfznx6	Low-intensity laser in the healing of second-degree burns: randomized and controlled clinical trial	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4981	Phototherapy in Burns reepitization: randomized and controlled clinical trials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8bfznx6	<NULL>	Volunteers who have suffered second degree burns; over 18 years of age; of both sexes; with stable physical state; no pre-existing metabolic diseases; able to carry out physical therapy treatment; in good mental health; without the presence of infection in the injured tissues; without the use of medications that alter the healing process.	Volunteers who develop associated dermatological diseases or infectious processes will be excluded from the study, as well as those who do not complete the therapeutic or evaluation procedure and those who drop out of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3r45cgs	Intervention to implement care monitoring for people living with HIV / AIDS	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4982	Intervention to implement continuous care monitoring for people living with HIV / AIDS	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-15	Departamento de Medicina Preventiva da FMUSP	Centro de Referência e Treinamento DST/Aids - Coordenação do Programa IST/Aids SES-SP	https://ensaiosclinicos.gov.br/rg/RBR-3r45cgs	<NULL>	This implementation study will include 30 outpatient care services for people with HIV chosen for their size and complexity, necessarily belonging to the health regions of São Jose dos Campos, Sorocaba, Itapeva, Caraguatatuba, Ribeirão Preto and Taubaté; CD4 and viral load test requesters.	Outpatient services that do not care for people with HIV; outpatient services for people with HIV who are not requesting CD4 and Viral Loading; outpatient services for people with HIV of other health regions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-7xzcmg7	Conventional Percutaneous surgery vs. Endoscopic Combined Intrarenal surgery for the treatment of large Kidney Stones	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4983	Conventional percutaneous nephrolithotomy with flexible antegrade nephroscopy vs. Endoscopic Combined Intrarenal Surgery (ECIRS): a prospective randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-31	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xzcmg7	<NULL>	"Adults aged 18 or over with kidney stones greater than 20 mm, candidates for PCNL in Barts position; Signed informed consent	."	Impossibility to perform retrograde ureteroscopy (e.g., urinary reconstruction); Contraindications to PCNL (untreated urinary infection, uncorrected coagulopathy, ipsilateral kidney tumor, pregnancy); Concurrent ureteral stone or simultaneous bilateral approach; Uncontrolled comorbidities; Refusal to sign consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-2vw8282	A study to evaluate the use of eSight magnifying glasses in adults with Low Vision	Not yet recruiting	Observational	2021-10-14	<NULL>	<NULL>	4985	A study to evaluate the use of eSight magnifying glasses in adults with Low Vision	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	https://ensaiosclinicos.gov.br/rg/RBR-2vw8282	<NULL>	lucid, mentally competent and with stable vision in the last 6 months who can attend the examination site. Best corrected visual acuity in the best eye ranging from 20/60 to 20/400 and / or visual field&gt; 20º (monocular or binocular) with one of the following comorbidities: Stargardt&apos;s disease, Eye coloboma, Nystagmus, Aniridia, Retinopathy of Prematurity, Macular degeneration Age-related, Retinal Detachment, Diabetic Retinopathy, Uveitis and other infectious diseases, Cone dystrophy, Leber&apos;s Congenital Amaurosis, Pigmentary Retinosis, Optic Nerve Hypopasia, Glaucoma, Optic Nerve Atrophy, Neuropathy. The patient must accept to use eSight in varied situations that simulate everyday situations and in public environments, open and or closed or at the discretion of the investigator.	Visual acuity better corrected in the best eye better than 20/60. Inability to attend the examination site to perform it. Inability to understand the use of the equipment and to provide data to assess its use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-43rj8f2	Anesthesia training	Not yet recruiting	Intervention	2021-10-14	<NULL>	<NULL>	4986	Simulation in anesthesiology	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-43rj8f2	<NULL>	Volunteer medical students or medical residents or professors of anesthesiology; both sexes.	Volunteers under 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-6w3w5b4	The impact of training with tasks performed simultaneously on memory and risk of falls in older adults	Not yet recruiting	Intervention	2021-10-14	<NULL>	<NULL>	4989	The impact of dual task training on cognition and risk of falls in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-15	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6w3w5b4	<NULL>	Elderly people with 60 years or more, without neurological and psychiatric disorders, living in the community.	Patients with cognitive decline, those with movement disorders, subjects with congenital or acquired amaurosis and those with severe cardiovascular and musculoskeletal comorbidities that preclude orthostatism and deambulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-8rczn6p	Assessment of pain, ease of insertion and clinical performance of three types of intrauterine devices (copper, Mirena® and Kyleena®) in adolescents	Not yet recruiting	Intervention	2021-10-15	<NULL>	<NULL>	4991	Assessment of pain, ease of insertion and clinical performance of three types of intrauterine devices (copper, Mirena® and Kyleena®) in adolescents: partially blind randomized study	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-11-10	Universidade Estadual de Campinas	Universidade de Gurupi- UNIRG	https://ensaiosclinicos.gov.br/rg/RBR-8rczn6p	<NULL>	Women up to 19 years old who want contraception with an IUD, nuligest or with children.	Confirmed or suspected pregnancy. Sexually Transmitted Disease (STD) active. Pelvic inflammatory disease.  Malformation of the uterus or intracavitary myoma that distorts the uterine cavity.Genital bleeding of an unknown nature. Previous surgery in the cervix.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3hqrvrr	Treatment of multiple gingival recessions using volume-stable collagen-based gingival graft substitute impregnated with blood platelet derivative: a split-mouth randomized clinical trial	Not yet recruiting	Intervention	2021-10-20	<NULL>	<NULL>	4993	Treatment of multiple gingival recessions with volume-stable collagen matrix impregnated by platelet aggregates: a split-mouth randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Santa Catarina	Osteology Foundation	https://ensaiosclinicos.gov.br/rg/RBR-3hqrvrr	<NULL>	Patients requiring root coverage for multiple gingival recessions; of both sides of the mouth; in homologous teeth; in the maxillary aesthetic zone (between teeth 15 and 25); without interproximal involvement; with a minimum of three adjacent teeth in each side of the maxilla should present marginal recession at least one of them with a recession depth equal or over 3 millimeters; patients should be equal or over18 years-old; present good oral health.	Uncontrolled systemic or local conditions; diabetic volunteers; pregnant women; volunteers with periodontitis; smokers; volunteers with a history of mucogingival or periodontal surgery at surgical sites; prosthetic crowns at teeth or implants in the surgical sites; gingival recessions with less than 1 mm of keratinized tissue apical to recession areas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3nvsj3z	Diet that mimics Fasting in patients with Breast Cancer treated by SUS: effects on reducing the effects caused, quality of life, progression, metastasis and tumor sensitization	Not yet recruiting	Intervention	2021-10-21	<NULL>	<NULL>	4995	Impact of implementing a Nutritional Protocol that Mimics Fasting in Breast Cancer patients treated by SUS: a proposal on reducing side effects, quality of life, progression, metastasis and tumor sensitization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3nvsj3z	<NULL>	Female patients have a histologically confirmed diagnosis of HER2-negative, early stage II/III breast cancer (cT1cN + or ≥T2 any cN, cM0), and who have not yet started chemotherapy, adequate bone marrow; adequate liver function; adequate kidney function; normal heart function; age ≥18 years; BMI&gt; 19 kg/m2; absence of diabetes mellitus; absence of allergy to MJD and signed consent form.	Previous 5-year malignancy, with the exception of a history of previous basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix; presence of other serious diseases, such as recent myocardial infarction, clinical signs of heart failure or clinically significant arrhythmias; BMI &lt; 19 kg/m2; patient with severe weight loss; pregnancy or breastfeeding; significant food allergies that would make the subject unable to consume the food provided; medical or psychological condition that, in the investigator&apos;s opinion, would not allow the patient to complete the study or sign a meaningful informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-6n6cdx8	Evaluation of hand movement learning in young adults using a cell phone	Not yet recruiting	Intervention	2021-10-27	<NULL>	<NULL>	5006	Evaluation of motor learning in young adults using a device mobile	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6n6cdx8	<NULL>	women;declared right;aged 18 to 25 years;without previous experience in the task.	evident and proven signs of aggravation of general health conditions;musculoskeletal changes without right upper limb;sinister laterality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-7yh6jk8	Manual treatment for mouth pain	Not yet recruiting	Intervention	2021-10-30	<NULL>	<NULL>	5009	Osteopathic Treatment in Patients with Temporomandibular Disorder	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2021-11-13	ESCOLA DE OSTEOPATIA DE MADRID - BRASIL LTDA	ESCOLA DE OSTEOPATIA DE MADRID - BRASIL LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7yh6jk8	<NULL>	Both sexes; be over 18 and have a maximum age of 45; not having used orthodontic braces; do not use fixed or mobile dental prostheses; not having rheumatic disease; not using analgesics; not have fibromyalgia.	Minor; be over 45 years old; fibromyalgia patient; have rheumatic disease, use daily analgesics, use fixed dental prosthesis; or mobile; having already used orthodontic braces.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-10br88dj	Evaluation of auriculotherapy associated with standard treatment in diabetic patients	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5021	Evaluation of the auriculotherapy effectiveness associated with standard treatment for patients with Diabetes Mellitus type II: Pragmatic, randomized, double-blind, multicenter clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal de Santa Catarina	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10br88dj	<NULL>	Age 18 years or older diagnosed with Type 2 Diabetes Mellitus	Body mass index greater than 30, amputees and on dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-107ynv85	Wires as an alternative to screws for bunion correction surgery: a randomized clinical trial.	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5022	Kirschner wires as an alternative to cannulated screws for hallux valgus correction using the minimally invasive chevron-Akin technique: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-09	Universidade Federal do Pará	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-107ynv85	<NULL>	- Patients of both genders; - Patients undergoing minimally invasive surgery, using the chevron-Akin technique, for moderate or severe hallux valgus correction; - Patients without previous history of surgery for hallux valgus correction; - Patients who failed conservative treatment; - Absence of instability of the first tarsometatarsal joint, defined as abnormal painful movement; - Absence of osteoathritis of the metatarsophalangeal joint of the hallux; - Absence of concomitant deformities of the hindfoot and midfoot; - Absence of rheumatological and neurological diseases.	- Patients who do not attend their return appointments; - Participants who request their removal from the research by their own initiative; - Death due to a reason unrelated to the complication of surgery during the follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-7pkypg3	Possible Effects of an Osteopathy care on mobility, balance and gait in people with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5023	"Possible Effects of an Osteopathic Manipulative Treatment Session on
mobility, balance and gait in patients with Parkinson&apos;s Disease"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-04	Universidade Federal do Rio de Janeiro	Instituto de Neurologia Deolindo Couto - INDC	https://ensaiosclinicos.gov.br/rg/RBR-7pkypg3	<NULL>	Adults with idiopathic Parkinson&apos;s disease diagnosed by a neurologist; Patients classified into stages 1 to 3 of disability on the Modified Hoehn &amp; Yahr scale; Being on stable antiparkinsonian medication; Montreal Cognitive Assessment (MoCA). No specific cutoff point will be adopted, but identification, by the evaluator, of the patients&apos; ability or not to obey verbal commands.	Presence of other associated neurological diseases; Important change in understanding and carrying out the tasks present in the MoCA; Rheumatic diseases in the acute phase; Previous history of spinal surgeries using osteosynthesis and arthrodesis-type procedures; Patients classified as stages 4 and 5 of disability on the Modified Hoehn &amp; Yahr scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-74wcnjc	Effect of using the Peanut Ball on labor: a randomized clinical trial	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5024	Effects of an exercise protocol with the aid of a peanut ball during labor without analgesia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-74wcnjc	<NULL>	Pregnant with single gestation; above 37 weeks; fetal cephalic presentation; usual gestational risk; over 18 years of age	Volunteers who present some complication during labor; admitted for labor induction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-739987q	Nail growth among elderly women under oral collagen: a placebo-comparative study.	Not yet recruiting	Intervention	2021-11-10	<NULL>	<NULL>	5031	Evaluation of nail physiology in elderly women supplemented with hydrolyzed oral collagen: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-12	Faculdade de Medicina de Botucatu (FMB Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-739987q	<NULL>	Women with more than 60 years; residents of the Botucatu-SP region; who agreed to participate in the study	Immunocompromised women or those using immunosuppressive drugs; diabetics; using anticoagulants or coagulation disorders; using oral retinoids; vegetarians; in protein supplementation; with kidney diseases; thyropathies and nail diseases and current clinical diagnosis will not be included previous or evidence of any medical condition that exposes the patient to increased risks or interferes with the safety or efficacy of the proposed treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-4j62jv6	Comparison of different ways to insert the Copper IUD in women after vaginal delivery	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5044	Comparison of Copper Intrauterine Device Insertion Methods in the immediate postpartum	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Hospital da Mulher Prof. Dr. J. A. Pinotti-Caism/Unicamp	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4j62jv6	<NULL>	Pregnant women between 18 and 43 years old; hemoglobin greater than 8.0 mg/dl during prenatal care; single pregnancy; desire to use IUD as a contraceptive method	Pregnant women with diagnosis or suspicion of ovular membrane infection; diagnosis of any other infection (anywhere); active sexually transmitted infection; uterine malformation (bicornuate, septate uterus); uterine fibroids that deform the cavity; pregnant women with scheduled cesarean	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-105wyncc	Platelet rich plasma and hyaluronic acid in shoulder tendon injuries	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5045	Use of platelet rich plasma and hyaluronic acid in rotator cuff injuries	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-12-27	Prevent Senior	Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-105wyncc	<NULL>	Adults aged between 40 and 85 years, regardless of gender; clinical and radiological diagnosis of tendinopathy or partial bursal lesions &lt;50% of the supra and infraspinatus thickness; availability of follow-up during the study period; provided voluntary written consent to participate in the study, confirmed by signing the informed consent form	Having other joint diseases or joint trauma, autoimmune diseases or intra-articular medication in the last 12 months; history of acute or chronic communicable diseases, including hepatitis B, hepatitis C and HIV; history of systemic bone or cartilaginous disorders; evidence of active infection or history of infection in the joint to be infiltrated in this study; comorbidity that the physician considers as a contraindication for the infiltration of platelet-rich plasma; chronic treatment with anticoagulant or immunosuppressive drugs; previous surgery (at any time) of the affected shoulder; presence of at least one of the following diseases: adhesive capsulitis, calcareous tendonitis, glenohumeral arthrosis or acromioclavicular joint disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-6q2wx4t	Analysis of the effectiveness of exercises performed in water on the memory of healthy elderly	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5048	Analysis of the effectiveness of aquatic physiotherapy on cognitive processes in healthy elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal Mato Grosso do Sul	Universidade Federal Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6q2wx4t	<NULL>	Sedentary elderly, of both sexes, aged between 60 and 90 years old, living in the municipality of Campo Grande / MS and who do not have neurological or psychiatric disorders	Elderly people with cognitive decline (associated or not with dementia), heart disease participants, subjects with fecal incontinence, unable to remain in orthostatism and people with difficulties in understanding the tests. Participants who have more than four consecutive absences in therapies, hydrophobia and a recent crisis of labyrinthine dysfunction will also be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-6qbx4h6	Study of formulations containing extract of Acmella oleracea (L.) R.K. Jansen (Asteraceae) (Jambu) in patients with decreased sexual potency or rapid ejaculation	Not yet recruiting	Intervention	2021-11-22	<NULL>	<NULL>	5055	Study of the clinical efficacy and safety of pharmaceutical formulations containing Acmella oleracea (L.) R.K. Jansen (Asteraceae) extract in patients with erectile dysfunction or premature ejaculation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-6qbx4h6	<NULL>	male, erectile dysfunction, stable affective relationship, fixed single partner, patients with premature ejaculation	anatomical genital deformities; erectile dysfunction secondary to spinal cord injury, concomitant diagnosis of other sexual dysfunctions , prolactin level greater than three times the upper limit, testosterone level less than 300, uncontrolled psychiatric disorder, decompensated diabetes mellitus, history of stroke, myocardial infarction, significant cardiovascular disease, poorly controlled arterial hypertension, history of important hematological, renal, hepatic abnormalities, abuse of illicit substances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-83mprnv	Assessment of left ventricular function using imaging exam	Not yet recruiting	Observational	2021-11-29	<NULL>	<NULL>	5060	Assessment of left ventricular function using Myocardial Strain in cardiac surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-15	Universidade do Extremo Sul Catarinense	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-83mprnv	<NULL>	Patients undergoing cardiac surgery with extracorporeal circulation (ECC) and left ventricular ejection fraction (LVEF) ≥ 50% who will undergo echocardiographic monitoring with myocardial strain.	Patients undergoing cardiac surgery without CPB, patients with LVEF &lt; 50%, urgent and emergency surgery, patients with grade II or III diastolic dysfunction, use of intra-aortic balloon pump in the preoperative period and refusal to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-9hfr3kf	Individualized Sports Mouthguards: Evaluation of Muscle Effects and Sports Performance in Children	Not yet recruiting	Intervention	2021-11-30	<NULL>	<NULL>	5063	Individualized Sports Mouthguards: Evaluation of Muscle Effects and Sports Performance in Children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-02	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9hfr3kf	<NULL>	Participants must present a normal nutritional status; mixed and/or permanent dentition, with the presence of the first four permanent molars; normal occlusion; absence of temporomandibular disorder; absence of other pathologies that could compromise the musculature of the stomatognathic system; and belong to the pre-established age group.	Individuals who present decompensated neurological and systemic pathologies, periodontal disease, cavitated caries lesions, parafunctional habits, under treatment with anti-inflammatory drugs and who are under orthodontic, speech therapy or otorhinolaryngological treatment will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-643zqt5	Analysis of physical activity and educational program on the burden and quality of life of caregivers of people with Amyotrophic Lateral Sclerosis.	Not yet recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5067	Effects of a physical activity program through a teleservice with an educational program on overload, depression, stress and quality of life of caregivers of people with Amyotrophic Lateral Sclerosis: Randomized Controlled Clinical Trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal do Rio Grande do Norte	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-643zqt5	<NULL>	Be an informal caregiver of a person diagnosed with ALS, be over 18 years old. Not having cognitive impairment to understand the course and the term of clarification. Being a caregiver of people with ALS, without other neurological disorders, has to be literate, with complete elementary education.	If they present any pathology that prevents them from performing physical activity. Caregivers in the first trimester of pregnancy. Or, are taking psychiatric medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4nq8cbp	Analysis of the benefits of Electrical Stimulation on the memory of healthy elderly people	Not yet recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5069	Transcranial Direct Current Stimulation on cognitive performance of healthy older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4nq8cbp	<NULL>	Sedentary elderly, of both sexes, aged between 60 and 90 years old, living in the municipality of Campo Grande / MS and who do not have neurological or psychiatric disorders	Elderly people with cognitive decline (associated or not with dementia), heart disease participants, subjects with difficulties in understanding the tests. Participants who have more than four consecutive absences in therapies and a recent crisis of labyrinthine dysfunction will also be excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-6nw2fdj	The Effect of Osteopathy in Patients with Fibromyalgia.	Not yet recruiting	Intervention	2021-12-03	<NULL>	<NULL>	5074	The Influence of Osteopathic Manipulative Treatment in Patients with Fibromyalgia Syndrome. A Randomized Controlled Clinical Trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-6nw2fdj	<NULL>	The inclusion criteria adopted in the study will be: The individuals participating in the study will be (a) women with a medical diagnosis of fibromyalgia or (b) who respond positively to the ACR test, (c) age not less than 18 years and not more than 60 years, (d) with pain for more than 3 months, (e) not pregnant, (f) no history of other concomitant pathologies of rheumatologic origin (rheumatoid arthritis, lupus).	The exclusion criteria are (a) not signing the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-7wjw5z6	Study to compare Chemotherapy and Hormone therapy performed before surgery in Breast Cancer patients who have positive hormone receptors:  response evaluation to proposed treatments	Not yet recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5078	Clinical and pathological response rates to Neoadjuvant Hormone Therapy and Chemotherapy in patients with Luminal subtype breast tumors: a randomized, open-label, non-inferiority trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-01-02	Instituto de Medicina Integral Prof. Fernando Figueira - IMIP	Instituto de Medicina Integral Prof. Fernando Figueira - IMIP	https://ensaiosclinicos.gov.br/rg/RBR-7wjw5z6	<NULL>	"Histological diagnosis of invasive breast carcinoma with Estrogen Receptor (ER) expression &gt; 50%, Ki 67 ≦ 35%, HER2 negative and Progesterone Receptor (PR) &gt; 20%;
• Tumor ≧ 2cm on ultrasound or Tumor &lt; 2cm with at least 1 axillary lymph node diagnosed with metastatic involvement – Metastatic involvement should be defined by cytology (USG guided FNA of the suspected lymph node) or histology (suspected lymph node core biopsy or biopsy of sentinel lymph node performed before neoadjuvant therapy)"	"Metastatic disease;
Inflammatory breast cancer;
Impossibility of surgical or drug treatment due to comorbidities such as decompensated heart failure or hematological and biochemical parameters within the patterns of patterns described:
Hemoglobin &lt; 7.0 g ∕ dL;
FA 1.5 times the reference value;
Neutrophil count &lt; 1500 U ∕mm3 ;
Platelet count &lt; 100,000 U ∕µL;
Serum creatinine &gt; 1.5 mg ∕ dL;
Score &gt; 2 on the ECOG Scale - Eastern Cooperative Oncology Group;
Contraindication to the use of at least one of the drugs proposed for the study;
Ongoing pregnancy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-8z4ctxq	Effect of green tea gel and hyaluronic acid on healing after wisdom teeth extraction	Not yet recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5079	Effect of green tea and hyaluronic acid gel on the healing of post-extraction sites of third molars a split-mouth randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8z4ctxq	<NULL>	Over 18 years of age; Have good oral hygiene (Plaque Index &lt; 20%); Presence the four third molars; Have indication for tooth extraction of all third molars	Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except diabetics); Decompensated diabetics (glycated hemoglobin above 8%); Pregnant or lactating women; Heavy smokers (above 10 cigarettes a day); Presence of periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-5sv27rh	Videosurgery or fibrinolysis for the treatment of pleural empyema in children admitted to intensive care unit	Not yet recruiting	Intervention	2021-12-08	<NULL>	<NULL>	5086	Pleural empyema in children admitted to the Icu: Clinical trial comparing fibrinolysis and videosurgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Hospital Infantil Joana de Gusmão	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-5sv27rh	<NULL>	Children with parapneumonic empyema and chest ultrasound with signs of high-grade empyema (gross septations, pleural thickening, pleural fluid hyperechogenicity) were admitted to the intensive care unit before treatment.	". Participants with contraindications to performing any procedure;
. Participants with hydropneumothorax in the pleural space, these findings that indicate video surgery as the treatment of choice;
. Medical record not filled out or incompletely filled out; and
. Unavailability of material for video surgery or fibrinolysis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-3q8syh4	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Observational	2021-12-08	<NULL>	<NULL>	5090	Evaluation of gynecological and dermatological acceptability of health products under normal conditions of use_Ave02.2021	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-03-21	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Avenca Indústria Cosmética Eireli -EPP	https://ensaiosclinicos.gov.br/rg/RBR-3q8syh4	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	Skin marks in the experimental area that interfere with the assessment of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergy to products from the tested category; Recent gynecological surgeries; Discharges; Immunodeficiency patients; Kidney, cardiac or liver transplants; Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.; Any condition not mentioned above that, in the investigator&apos;s opinion, could compromise the study evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-5zgy25w	Effect of a non-drug intervention on pain and anxiety during influenza vaccination	Not yet recruiting	Intervention	2021-12-09	<NULL>	<NULL>	5094	Effect of a non-pharmacological intervention on pain and anxiety related to the administration of influenza vaccine in adults: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Departamento de Medicina e Enfermagem da Universidade Federal de Viçosa	Departamento de Medicina e Enfermagem da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5zgy25w	<NULL>	Age 18 years and over; both sexes; preserved cognition; be literate; receive only injection of the influenza vaccine via IM in the deltoid region	Participants reporting pain in the upper limbs; presence of injury or abrasions in the deltoid region; loss or alteration of sensation in the upper limbs, previous use of analgesics in the last six hours prior to immunization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-97rb5wk	Physiotherapy for Women After Gynecologic Pelvic Cancer Treatment.	Not yet recruiting	Intervention	2021-12-13	<NULL>	<NULL>	5101	"Rehabilitation Program of Pelvic Floor 
Post-Surgery and Radiotherapy
for Gynecological Pelvic Cancer: Randomized and Controlled Clinical Trial."	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2022-02-01	Faculdade de Medicina de Ribeirão Preto	Centro de Pesquisa Oncologica	https://ensaiosclinicos.gov.br/rg/RBR-97rb5wk	<NULL>	Age group older than 18 years; Clinical staging I to III of pelvic gynecological cancer; Having undergone surgery, radiotherapy, and/or brachytherapy;  Have urinary incontinence;  Do not present any orthopedic or neurological limitations that prevent the practice of the rehabilitation program; Not being under physiotherapeutic treatment.	Withdrawal of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-8p36d5m	The Effects of Transcranial Photobiomodulation in Adults with Mild Cognitive Impairment	Not yet recruiting	Intervention	2021-12-13	<NULL>	<NULL>	5105	The Impact of Transcranial Photobiomodulation on Adult Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8p36d5m	<NULL>	Individuals of both sexes, with a diagnosis of Mild Cognitive Impairment will be included in this study	Individuals with epilepsy; hypersensitivity to light; with immunodepressive; oncological; infectious diseases or with characteristic symptoms of suspected COVID-19 infection; or confirmation of COVID-19 by test; pregnant or lactating women will be excluded from this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-299z6qr	Rehabilitation Program for people after COVID-19 infection	Not yet recruiting	Intervention	2021-12-14	<NULL>	<NULL>	5108	Rehabilitation after Covid-19: Implementation and evaluation of a rehabilitation and case monitoring program	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-299z6qr	<NULL>	Volunteers aged between 18 and 70 years, of both genders;  have been diagnosed (by laboratory tests) with COVID-19;  be outside the acute phase of the disease; present need for rehabilitation; not present neurological or cognitive deficits that interfere in the performance of any of the proposed activities.	Patients who voluntarily require the study to leave; not adapt to the proposed protocols; missing more than 3 consecutive sessions without justification; who have cardiovascular, respiratory or neurological alterations that compromise the performance of the proposed rehabilitation activities and that configure the need for medical evaluation for possible evaluations of the presented conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-9tqr2jt	Effectiveness of Exercise In Neck Pain due to Whiplash Associated Disorders	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5112	Exercise-Induced Hypoalgesia in Acute/Subacute Whiplash Associated Disorders: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	University of Seville	University of Seville	https://ensaiosclinicos.gov.br/rg/RBR-9tqr2jt	<NULL>	Inclusion criteria are aged between 18-65 years, have sustained a whiplash injury within the last 7 and 30 days, diagnosis of WAD grade IIaccording to Quebec Task Force	Exclusion criteria are WAD grade I, III or IV injury (neurological deficit, fracture or dislocation), presence of previous generalized pain or neuropathic pain condition, nerve root compromise (at least 2 of the following signs: weakness/reflex changes/sensory loss associated with the same spinal nerve), loss of consciousness after the accident, instability signs, psychiatric disorders, inflammatory or rheumatic disease, or tumours, previous surgery in the cervical or upper limbs region, previous whiplash injury, unwilling to perform a prescribed exercise intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-5hvgtky	Effectiveness of nutritional intervention to management Systemic Arterial Hypertension in Primary Health Care	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5115	Nutritional intervention to control Systemic Arterial Hypertension in Primary Health Care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-03	Universidade Federal de Ouro Preto	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5hvgtky	<NULL>	Both sexes; over 20 years old	Volunteers with cardiovascular disease, angina, heart attack, heart failure, atherosclerosis, peripheral vascular disease, ischemic cerebrovascular disease, chronic liver, kidney or infectious diseases evaluated by medical history; 10% change in body weight two months prior to the study; use of anti-inflammatory drugs; women on exogenous ovarian hormone replacement, pregnancy or breastfeeding; people with special needs; Alzheimer&apos;s disease, dementia or life expectancy shorter than study duration; cognitive difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-7g9jtsm	The effectiveness of Biofeedback and Therapeutic Exercise on symptoms related to Tooth Clenching while awake	Not yet recruiting	Intervention	2021-12-20	<NULL>	<NULL>	5119	Effectiveness of Biofeedback and Therapeutic Exercise on fatigue, pain and mandibular function in subjects with Awake Bruxism: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7g9jtsm	<NULL>	Men and women between the ages of 18 and 45; Diagnosis of awake bruxism or diagnosis of both awake bruxism and sleep bruxism by a dentist; Complaints of pain or discomfort in the facial region for at least 3 months (chronic pain); Report of clenching or grinding of teeth while awake in the last 3 months	Presence only of sleep bruxism; History of facial trauma, rheumatic, neurological and orthopedic pathologies; Surgical procedures performed in the craniocervical region; Use of orthodontic appliance during the treatment period and removal of the same less than 3 months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9dyq9jr	Pharmaceutical guidelines on the characteristics of prescription drug treatment for elderly people with heart-risk diseases	Not yet recruiting	Intervention	2021-12-21	<NULL>	<NULL>	5123	Intervenções farmacêuticas sobre a complexidade da farmacoterapia em Idosos com doenças de risco cardiovascular: um ensaio clínico randomizado, controlado	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9dyq9jr	<NULL>	Be 60 years of age or older; Carry out outpatient follow-up by outpatient physicians; Have at least one of the following diagnosed clinical conditions: systemic arterial hypertension, diabetes mellitus and dyslipidemia, according to the criteria recommended by the Brazilian guidelines for these clinical conditions; Present uncontrolled blood pressure and/or glycemic and/or lipid levels in accordance with established goals for the level of cardiovascular risk; Use medication for at least one of the chronic conditions mentioned above for more than six months	Diagnosis of resistant or secondary systemic arterial hypertension; Diabetes and/or secondary dyslipidemia; End stage of kidney disease; Liver disease; Cancer treatment; Acquired immunodeficiency syndrome or anticoagulation; Unstable psychiatric illness; Service provided by other pharmacists; Inability to attend scheduled appointments; Missing in more than two consecutive appointments; Withdrawal from participating in the study at any stage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-2394x96	Guided regeneration with polydioxanone membrane (PDO) in dental alveoli after extraction: volumetric analysis	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5126	Comparative, prospective and randomized clinical study of guided regeneration with Polydioxanone membrane (PDO) in dental alveoli after extraction: volumetric analysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	M3 Health Indústria e Comércio de Produtos Médicos, Odontológicos e Correlatos Sociedade Anônima	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-2394x96	<NULL>	Patients must have all four bone walls after the extraction procedure; over 18 years old; who have signed the informed consent form	Uncontrolled systemic commitments; teeth in areas of tumor lesions; acute infectious processes; deciduous dental elements; untreated periodontal problems; smokers; radiated in the head or neck region; allergy to any component used in the research; psychological disorders; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-76wmm3q	Split-mouth randomized clinical trial to compare ceramic and autogenous bone grafts.	Not yet recruiting	Intervention	2021-09-14	<NULL>	<NULL>	5132	Use of 3D ceramic block graft compared to autogenous block graft for bone augmentation of atrophic maxilla. Split-mouth randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	M3 Health Ind. Com. de Prod. Méd., Odont. e Correlatos SA.	Faculdade de Odontologia de Araraquara (FOAr/UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-76wmm3q	<NULL>	Bone insufficiency in the anterior region, with a minimum height of 7mm and width less than or equal to 5mm evaluated by cone beam computed tomography; Over 18 years old; who have signed the informed consent form.	"Patients who present general contraindications to the surgical procedure;Patientes submitted to radiation in the head and neck region; Patients with immunosuppression or immunosuppression; Patients treated or undergoing treatment with anti-resorptive drugs or that alter bone metabolism; Patients with untreated periodontal disease;Patients with poor oral hygiene; Pregnant and lactating women; Uncontrolled diabetic patients; Patients with psychiatric problems or unrealistic expectations;
Smokers."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-5jnbyhk	Effect of hospitalization on nutritional status and risk of dysphagia in people older than 65 years of age	Not yet recruiting	Observational	2022-01-03	<NULL>	<NULL>	5133	Impact of hospitalization on nutritional status and the risk of dysphagia in people aged 65 years. Multicentre study &quot;NUTRIFAG&quot;	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Department of Nursing, University of Alicante, Alicante Institute for Health and Biomedical Research (ISABIAL),	Universidad de Alicante	https://ensaiosclinicos.gov.br/rg/RBR-5jnbyhk	<NULL>	patients 65 years of age or older; hospitalized in medical or surgical units; admitted for more than 48 hours; informed consent of the patient or legal guardian	patients with enteral or parenteral nutrition on admission; terminally ill patients or patients with a primary diagnosis of cancer; patients admitted to critical care units	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-2ggx7sm	Vaccine Plasma for the Treatment of COVID-19 Infection	Not yet recruiting	Intervention	2022-01-11	<NULL>	<NULL>	5142	"COVID-19-vaccinated plasma for treatment of the infection by SARS-CoV-2: a Multicenter,
Randomized, Open-Label, Parallel-Group Trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-13	Ministério da Ciência, Tecnologia e Inovações	Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS	https://ensaiosclinicos.gov.br/rg/RBR-2ggx7sm	<NULL>	Age ≥ 18 years with or without comorbidity; COVID-19 mild (WHO clinical progression scale ≤ 2); Symptoms duration less than 72 hours; Laboratory confirmation of COVID-19, by detecting the viral antigen in respiratory secretions, collected by nasal swab (PanbioTM COVID-19 Ag, Abbott®); Signature, by the patient or a legal representative, of the informed consent form	Pregnant women; Patients in palliative care; Refusal to sign the TCLEP; Patients immunized with two doses of the immunizers, with the exception of individuals over 80 years of age who have been immunized with Coronavac vaccine for more than 6 months; Patients with suspected reinfection; Allergic reactions prior to plasma transfusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4dcjfr7	Therapy with Nerve Electrical Stimulation associated with the drug Desmopressin for the treatment of children who wet the bed during their sleep	Not yet recruiting	Intervention	2022-01-18	<NULL>	<NULL>	5153	Desmopressin-associated Transcutaneous Parasacral Nerve Stimulation in Monosymptomatic Enuresis: a blinded, randomized, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4dcjfr7	<NULL>	Children and adolescents aged 6 to 11 years, 11 months and 29 days with a diagnosis of primary NME; not receiving any enuresis treatment modality in the last 2 months; children and adolescents whose parents or guardians agreed to participate in the study, after reading, understanding and signing the Informed Consent Form (FICF) and Informed Consent Form.	"Use of medication that changes the action of the detrusor muscle or external urethral sphincter; use of pacemaker; presence of polydipsia of any etiology;presence of moderate to severe intellectual disability of any nature identified by Raven&apos;s Progressive Matrices Test; families who refuse to attend the research clinic once a week
- Children and adolescents diagnosed with primary NME and whose parents or guardians did not accept to participate in the study and/or did not sign an Informed Consent Form (FICF) and an Assent Term
- Non-monosymptomatic or secondary enuresis"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-9jmw7k3	Effects of β-alanine supplementation on performance and recovery in Crossfit practitioners	Not yet recruiting	Intervention	2022-01-21	<NULL>	<NULL>	5158	Effects of chronic β-alanine supplementation on physical performance and recovery in Crossfit practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9jmw7k3	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 40 years; Crossfit® practitioners who train in the most advanced category of the modality, in which they perform the movements and training loads as prescribed by the trainer (category RX) for at least 3 months.	Vegetarian or vegan volunteers; with use of anti-inflammatory drugs; with the use of anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-10gx2qhj	Efficacy of the oral use of the drug melatonin in the treatment of facial melasma in women.	Not yet recruiting	Intervention	2022-01-21	<NULL>	<NULL>	5159	Efficacy of the use of oral melatonin in the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Medicina de Botucatu (FMB Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-10gx2qhj	<NULL>	Women with facial melasma 18 to 60 years old, Fitzpatrick&apos;s phototypes II to V.	Patients with other concomitant facial skin diseases, skin diseases with photosensitivity, melasma with mMASI less than 5, history of hypersensitivity to the active substance oral melatonin or to any other component of the formulation described, pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7gw2794	Auditory and visual stimuli test proposal for tinnitus patients evaluation	Not yet recruiting	Observational	2022-01-25	<NULL>	<NULL>	5167	An auditory-visual Stroop test proposal for tinnitus patients evaluation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-20	Universidade Federal de São Paulo (UNIFESP-EPM)	Universidade Federal de São Paulo (UNIFESP-EPM)	https://ensaiosclinicos.gov.br/rg/RBR-7gw2794	<NULL>	As inclusion criteria, will be selected, individuals aged between 18 and 59 years old, with tinnitus and hearing thresholds within normal limits for pure tone audiometry or hearing loss at high frequencies (above 3kHz). Such subjects must have performed acuphenometry in a previous audiological evaluation and must present constant subjective tinnitus, of the whistle or wheezing type, uni or bilateral. The Control Group will comprise individuals without tinnitus, aged between 18 and 59 years, pure tone audiometry within normal limits or with hearing loss at high frequencies (from 3kHz), with no history of neurological and/or psychiatric alterations.	Individuals with pulsatile tinnitus, psychiatric or neurological diseases diagnosed up to the time of test execution will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-69w6f5z	The effect of music on pain relief in post-cardiac surgery patients	Not yet recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5171	Effect of music on pain relief during the bath in the bed of individuals in post-operative heart surgery: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Sabrina Daiane Gurgel Sarmento	Hospital Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-69w6f5z	<NULL>	age eighteen years or older; submit to bed bath in the first twenty-four hours of coronary artery bypass graft surgery; have a score between fourteen and fifteen on the Glasgow Coma Scale	decreased hearing acuity; not following institutional bed bath protocol; changes in vital signs; prescription of analgesics different from the institutional protocol for the postoperative period of cardiac surgery; not liking music or associating it with negative experiences; having undergone surgery anteriorly open heart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-8ht5nqq	Tele Rehabilitation for Women with Urinary Incontinence after Gynecological Pelvic Cancer Treatment.	Not yet recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5173	Tele Rehabilitation Program of the Pelvic Floor in Women with Urinary Incontinence After Surgery, Radiotherapy and/or Brachytherapy for Gynecological Pelvic Cancer: Randomized and Controlled Clinical Trial.	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2022-03-10	Faculdade de Medicina de Ribeirão Preto	Centro de Pesquisa Oncologica	https://ensaiosclinicos.gov.br/rg/RBR-8ht5nqq	<NULL>	Age group older than 18 years; Clinical staging I to III of pelvic gynecological cancer; Having undergone surgery, radiotherapy, and/or brachytherapy; Have urinary incontinence; Do not present any orthopedic or neurological limitations that prevent the practice of the rehabilitation program; Not being under physiotherapeutic treatment.	Withdrawal of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-9n9yq4p	Effect of acute caffeine intake on rating of perceived exertion, muscle pain and fatigue during exercise in women with fibromyalgia	Not yet recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5175	Effect of acute caffeine intake on perceptive responses, muscle oxygenation and neuromuscular fatigue development during exercise in women with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9n9yq4p	<NULL>	Volunteers with an age between 30 and 60 years; be classified as sedentary or insufficiently active according to the  international physical activity questionnaire; clinical diagnosis of fibromyalgia according to the American College of Rheumatology criteria	tobacco usage; any kind of bone or muscle injury that prevent to perform the exercise tests; any restriction related to caffeine intake or physical exercise practice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-5d5y7ts	Remote educational intervention in prenatal care for the empowerment of pregnant women in labor and birth	Not yet recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5182	Effect of a remote prenatal educational intervention on empowering pregnant women in labor and birth: a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-29	Universidade de Pernambuco	Secretaria Municipal de Saúde de Vitória de Santo Antão	https://ensaiosclinicos.gov.br/rg/RBR-5d5y7ts	<NULL>	Pregnant women aged 18 years or over who are undergoing prenatal care at usual risk, exclusively, in family health units and with gestational ages between 25 and 30 weeks, literate and who have a landline and/or cell phone, will be included.	Twin pregnancy; pregnant women over 32 weeks, because at the time of post-intervention collection they may be in labor or may have already given birth, thus compromising the final follow-up of the research, which is data collection during the gestational period; be a health care professional.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-2hdrph7	Osteopathic treatment in individuals with Anxiety and the effects over the Autonomic nervous system - A randomized clinical trial	Not yet recruiting	Intervention	2022-01-28	<NULL>	<NULL>	5184	Osteopathic manipulative treatment in individuals with Anxiety disorders symptoms and the effects over the ANS - A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-13	Escola de Osteopatia de Madrid - Brasil	Escola de Osteopatia de Madrid - Brasil	https://ensaiosclinicos.gov.br/rg/RBR-2hdrph7	<NULL>	"Women who meet the mild and moderate symptoms of the Hamilton Anxiety Scale will be included;
It has an age range between 18 and 55 years old;
Agree to the Informed Consent Form (FICF) in accordance with Appendix A."	"Patients with a HAM-A score equal to or above 30 will be excluded;
Present other psychiatric or cognitive disorders;
Inability to complete the questionnaires;
Associated serious pathologies (such as cancer or severe heart disease);
Pregnant women;
Being addicted to alcohol or drugs;
Not being 18 years old before the beginning of the evaluations;
Have completed 56 years or older by the end of the assessments;
Use anxiolytic medications during the study period or in the last 6 months;
Have undergone manual osteopathic treatment in the last 3 months;
If you are absent from any stage of the research protocol;
Present any suspicious symptoms (fever, cough, runny nose, difficulty breathing, excessive tiredness, loss of smell or taste) and/or diagnosis of Covid 19;
Not using or refusing to wear a personal protective mask."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-2ssyb6q	Usability, acceptability and feasibility of a digital intervention to promote healthy lifestyle: a pilot study	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5194	Usability, acceptability and feasibility of a digital intervention to promote healthy lifestyle: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-15	Instituto de Comunicação e Informação Científica e Tecnológica em Saúde	Instituto de Comunicação e Informação Científica e Tecnológica em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-2ssyb6q	<NULL>	Men and women ; who live in Rio de Janeiro (RJ) ;  18 years or over; Unified Health System (SUS) users; have a personal computer or smartphone;  have a data plan for internet access; agree to participate in the study	restrictions or clinical conditions that contraindicate the practice of physical exercise; use of diets prescribed by health professionals due to clinical conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-10rnr53n	Increase in Hand Strength and Through the Influence of Contralateral Index Finger Strength in Individuals with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5196	Increased Palmar Grip Strength and Overflow-Induced Hand Speed Contralateral to Isometric Contraction of the Index Finger in Individuals with Parkinson&apos;s	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10rnr53n	<NULL>	Volunteers with a diagnosis of Parkinson&apos;s Disease; both genders; aged between 18 and 70 years; who can understand the requested activity; who agreed to participate in the study voluntarily.	Individuals with another associated neurological disease; individuals with dementia; individuals with an upper limb or part of it amputated; individuals with associated cognitive alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-2jws7dv	Effect of an Educational Technology about sex transmitted Infections for women deprived of liberty	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5197	Educational Technology on Sexually Transmitted Infections for incarcerated women: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2jws7dv	<NULL>	Incarcerated women, regularly enrolled at the Olga Benário Prestes State School that operates within the chosen prison unit and with a minimum stay of 2 months.	Women who were not authorized by the prison unit or school administration for conduct that represents a risk for those involved; and pregnant women, for presenting information about STIs during prenatal consultations, which can be considered a bia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7xnnb4z	Effectiveness of periodontal treatments in obese and diabetic individuals	Not yet recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5201	Evaluation of different treatments for periodontal diseease in obese and diabetic individuals - Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Thayná Nathally Petry de Paula	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7xnnb4z	<NULL>	As inclusion criteria, patients will be of both sexes, with diabetes mellitus II (Glycated hemoglobin greather or equal to 7% at the last medical check-up) and stage II or III Grade C periodontitis; with at least 4 sites with probing depth above 5mm and level of clinical attachment greater than or equal to 4mm, not on the same tooth, with bleeding on probing and gingival inflammation, free of caries and/or prostheses on clinical examination; All patients must have at least 12 teeth present, excluding third molars and teeth suitable for extraction	As exclusion criteria, patients must present a positive history in the last six months of antibiotic therapy, steroid or non-steroidal anti-inflammatory drugs, anticoagulants and immunosuppressants in the three months preceding the study; positive history of pregnancy or breastfeeding; positive history of use of contraceptives or any other form of hormone; positive history of smoking or permanent cessation of the habit for at least 5 years; positive history of periodontal treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-2fzkjtx	Effectiveness of a training program aimed at medical residents in oncology to help manage cancer pain in a referral hospital	Not yet recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5202	Implementation of a training program directed to oncology resident physicians to support cancer pain management in a reference hospital	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-2fzkjtx	<NULL>	First-year residents in clinical, surgical, radiotherapy and hematology oncology	First-year residents who do not wish to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-74nhx9	Effects of an Intervention involving exercises for the entire lower limb in athletes with knee pain caused by Patellar Tendinopathy	Not yet recruiting	Intervention	2019-12-10	<NULL>	<NULL>	5209	Effects of an intervention addressing kinetic chain factors in athletes with Patellar Tendinopathy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-74nhx9	<NULL>	Inclusion criteria for this study will be: male athletes between 15 and 40 years old;  Practice physical activities involving high demand for the knee extensor mechanism (volleyball, basketball, handball, soccer, running, etc.) for at least 2 times a week; Present with pain localized in the apex of the patella, patellar tendon or its insertion in the tibial tuberosity, confirmed by palpation; Present with pain during activities that impose load on the patellar tendon (jumping, squatting, etc.) for more than 3 months; Present with pain in the patellar tendon during the single-leg decline squat test; Score less than 88 points on the Victorian Institute of Sport Assessment - Patella (VISA-P) questionnaire.	Athletes will be excluded from the study if they: have been using or have used corticosteroid medication in the last 6 months; Have symptoms related to trauma or who have had knee surgery; have knee symptoms associated with other dysfunctions, such as patellofemoral pain, intra-articular injuries, patellar instability, and Osgood-Schlatter or Sinding-Larsen-Johansson disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-79sm4vd	Analgesia after dental implant surgeries	Not yet recruiting	Intervention	2022-02-14	<NULL>	<NULL>	5210	Postoperative analgesia in Implant Dentistry	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-79sm4vd	<NULL>	Adult patients (aged 18 years or older), of both sexes, who need surgery to install at least 3 dental implants or dental implant protocols, with the objective of prosthetic rehabilitation will be included.	"Individuals will be excluded:
- who present a previous picture of chronic or acute pain, related or not to the oral cavity,
- in chronic or acute systemic use (in the 48 hours prior to the procedure) of analgesic, anti-inflammatory and/or muscle relaxant,
- with difficulty in understanding instructions (cognitive changes), which impair the application of the scales proposed by the study, such as illiterate patients, with inability to numerically notate and write the pain parameters proposed by the study,
- with contraindication for the use of ibuprofen,
- with contraindication for the use of paracetamol associated with codeine."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-5gn27x8	Use of the Hammock position as a stimulus for Sleep in Pre-term newborns	Not yet recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5214	Use of de Hammock position as a Sensory stimulus for Sleep in Pre-term newborns interned in a Neonatal unit	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-02-21	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5gn27x8	<NULL>	Weight of less than 2,000g; Gestational age less than 37 weeks; More than 72 hours of life; Clinical stability.	"Neonates with neurological and/or syndromic impairments; Newborns using oxygen therapy; Newborns with injuries or fractures of bones; Neonates submitted to painful invasive procedures less than 1 hour after the study intervention;
Newborn “failed” in the ear test; Neonates using medications that may change some of the independent variables; Children awaiting surgery or transfer to another Hospital."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-28x7hqf	Effects of Percussive Massage Gun massage on the physical assessment of athletes: a randomized controlled trial	Not yet recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5218	Effects of the Percussive Massage Gun on clinical and biomechanical outcomes in athletes: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Ceará	Departamento de Fisioterapia da Universidade Federal do Ceará (UFC)	https://ensaiosclinicos.gov.br/rg/RBR-28x7hqf	<NULL>	Age equal to or greater than 18 years old, with at least six months of practice with weekly training frequency equal to or greater than three days, and who have not suffered musculoskeletal injuries in the last three months	Practitioners unable to perform the biomechanical tests, pregnant women, using a cardiac pacemaker, with cognitive impairment or who have undergone any surgical procedure in the last three months will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-9dr3dt7	Pressure waves and Back Pain	Not yet recruiting	Intervention	2022-02-18	<NULL>	<NULL>	5229	Shock wave and Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9dr3dt7	<NULL>	Low back pain for three months or more; Age 18-80 years; Low back pain with intensity equal to or greater than three on the numerical pain scale	Infection, fracture and previous surgery on the lumbar spine; Cauda equina syndrome; Pregnancy; Neuropathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-73zrnjh	Efficacy of the oral use of the drug N-acetylcysteine in the treatment of facial melasma in women	Not yet recruiting	Intervention	2022-02-21	<NULL>	<NULL>	5233	Efficacy of the use of oral N-acetylcysteine in the treatment of facial melasma in women: A randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Medicina de Botucatu (FMB - Unesp)	Faculdade de Medicina de Botucatu (FMB - Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-73zrnjh	<NULL>	Women with facial melasma 18 to 60 years old, Fitzpatrick&apos;s phototypes II to V	Patients with other concomitant facial skin diseases, skin diseases with photosensitivity, melasma with mMASI less than 5, history of hypersensitivity to the active substance oral melatonin or to any other component of the formulation described, pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-9z6dw6b	Use of Cannabidiol in Patients with Chronic Heart Failure	Not yet recruiting	Intervention	2022-02-21	<NULL>	<NULL>	5235	Cannabidiol in Patients with Chronic Heart Failure: a prospective, randomized, double-blind, controlled trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-03-01	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9z6dw6b	<NULL>	Age: 18 years to 70 years; Established documented diagnosis of Heart Failure (HF) With Reduced Left Ventricle Ejection Fraction (LVEF less than 40%), which has been present for at least 12 months; Persisted HF symptoms and low quality of life defined as: New York Heart Association (NYHA) functional class III-IV or NYHA functional class II and at least one criteria: Minnesota Living with Heart Failure Questionnaire (MLHFQ) score greater than or equal to 50 points; 6 minute walk test less than 325 metres; Elevated BNP levels; Patients should receive standard of care for heart failure with reduced ejection fraction (HFrEF) and be treated according to locally recognized guidelines	Expected surgical or percutaneous treatment for HF (coronary revascularization, valve procedure, implantation of resynchronization therapy or implantable cardioverter-defibrillator, heart transplantation, left ventricular assist device) within the next 6 months of randomization; Current acute decompensated HF or hospitalization due to decompensated HF within 30 days prior to enrolment; Acute myocarditis within 6 month prior to enrolment; HF due to restrictive cardiomyopathy, constrictive pericarditis, hypertrophic (obstructive) cardiomyopathy or uncorrected primary valvular disease; HF etiology that presents potential reversibility of the disease according to the investigators&apos; judgment; Myocardial infarction or unstable angina within 6 month prior to enrolment; Coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or valvular repair/replacement within 6 month prior to enrolment or planned to undergo any of these operations after randomization; Previous cardiac transplantation or implantation of a ventricular assistance device or similar device, or implantation expected after randomization; Implantation of a Cardiac resynchronization therapy (CRT) or implantable cardioverter-defibrillator (ICD) within 6 month prior to enrolment or intent to implant a CRT or ICD device; Patient in a cardiovascular rehabilitation program; Stroke or transient ischemic attack within 12 month prior to enrolment; Severe (eGFR less tha 20 mL/min/1.73 m2 by CKD-EPI), renal disease at the time of randomization; Any condition outside the cardiovascular and renal disease area, such as but not limited to malignancy, with a life expectancy of less than 2 years based on investigator’s clinical judgment; Limiting or disabling neurological or musculoskeletal conditions; Current Sars-Cov2 infection or hospital discharge for COVID-19 within the last 30 days; Post-COVID-19 syndrome defined by persistence or onset of symptoms or sequelae (eg, fatigue, chest pain, dyspnea, decreased quality of life, muscle and joint pain, anxiety, sleep disturbances, palpitations or thromboembolism) after 4 weeks of SARS-Cov2 infection, not attributed to other causes; Active malignancy; Women who have a positive pregnancy test at enrolment or randomization, or women who are breast-feeding; Use of Illicit drugs within 24 month prior to enrolment; Severe Hepatic impairment; Human immunodeficiency virus (HIV) patients; Seizures or use of anticonvulsants drugs; Schizophrenia, bipolar disorder or attempted suicide; Glaucoma; Hypersensitivity to any cannabinoid substance or contained in cannabidiol extract; Any systemic disease evaluated by the investigators that compromises the result or poses a risk to the trial; Inability of the patient, in the opinion of the investigator, to understand and/or comply with study medications, procedures and/or follow-up, or any conditions that, in the opinion of the investigator, may render the patient unable to complete the study; Participation in another clinical research protocol; Refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-4xcrxcm	Effects of a physical exercise treatment before hemodialysis sessions on motor skill, cognition and quality of life outcomes: a randomized clinical trial	Not yet recruiting	Intervention	2022-02-22	<NULL>	<NULL>	5238	Chronic effects of a physical exercise intervention prior to hemodialysis sessions on Motor Performance, Cognition and Quality of Life outcomes: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Universidade Federal de Pelotas	Hospital Universitário São Francisco de Paula	https://ensaiosclinicos.gov.br/rg/RBR-4xcrxcm	<NULL>	Individuals diagnosed with chronic kidney disease on renal replacement therapy by hemodialysis; aged 50 or over; of both sexes; individuals on hemodialysis for at least three months with a minimum frequency of three times a week.	Individuals with a clinical diagnosis of musculoskeletal limitations; visual and auditory disturbances that prevent the performance of the tests; individuals with catheter in femoral or jugular vein; blood pressure equal to or greater than 220/110 mmHg or equal to or less than 100/60 mmHg; individuals who perform structured physical exercise, class III and IV angina; uncontrolled diabetics; cardiac arrhythmias; heart failure class III or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-5z5h789	Combined Functional Exercises with Mindfulness for improve physical and cognitive function in Older Adults with Slow Gait Speed and Cognitive Complaints	Not yet recruiting	Intervention	2022-02-22	<NULL>	<NULL>	5239	Optimizing the body-mind interaction through combining Functional Exercises and Mindfulness: effects on physical and cognitive function of Seniors with Motoric Cognitive Risk Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Universidade de Pernambuco - UPE (Campus Petrolina)	Universidade de Pernambuco - UPE (Campus Petrolina)	https://ensaiosclinicos.gov.br/rg/RBR-5z5h789	<NULL>	We will recruit older adults, 65 years and older, with MOTORIC Cognitive Risk Syndrome	We will exclude participants who have the following criteria. not being able to speak and understand the Portuguese; not being able to walk at least 10 meters without mobility aids (eg, cane); participate in structured physical exercise programs for at least 3 months; have exacerbated walking impairment due to  musculoskeletal disorders or neurological motor deficit (eg, severe osteoarthritis, lower limb amputation, Parkinson&apos;s disease, stroke with motor sequelae); use antipsychotic-type drugs, have a diagnosis of major depression or any-type dementia;  have unstable cardiovascular or metabolic diseases (eg, angina pectoris, decompensated diabetes) or chronic complications (eg, retinopathy, neuropathy) that precludes structure exercise engagement; not having adequate visual and auditory capacity to perform the cognitive assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-4yhbqwk	Effects of adding a online behavioral intervention to exercise therapy and patient education compared to exercise and education delivered online for people with anterior knee pain	Not yet recruiting	Intervention	2021-06-04	<NULL>	<NULL>	5246	Effects of an online program including mindfulness, exercise therapy and patient education compared to online exercise therapy and patient education for people with Patellofemoral Pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-05	Universidade Estadual Paulista Júlio de Mesquita Filho Campus Presidente Prudente	Universidade Estadual Paulista Júlio de Mesquita Filho Campus Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-4yhbqwk	<NULL>	Participants who meet the following criteria will be included: (i) age between 18 and 40 years; (ii) previous unilateral knee pain when performing at least two of the following activities: staying seated for a prolonged period, squating, kneeling, running, going up and down stairs, jumping and landing from jumping; (iii) previous knee pain with insidious onset of at least 6 months; (iv) worse self-reported pain in the last month of at least 30 mm on the visual analog scale (VAS) of 100 mm.	Participants who meet the following criteria will not be included in the study: (i) previous self-reported knee pain caused by knee trauma; (ii) history of dislocation or patellar subluxation; (iii) clinical evidence of meniscal injury or ligament instability assessed by a trained physical therapist; (iv) clinical osteoarthritis in any joint of the lower limbs evaluated by a trained physiotherapist according to the EULAR criteria; (v) patellar tendinopathy assessed by a trained physical therapist; and (vi) previous physical therapy for the treatment of DFP (at least 6 months prior to the study) and (vii) answer “yes” on any questions on the PAR-Q physical activity readiness questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-48gkx3m	Analgesic effect of the use of Adjuvants in Peripheral Nerve Blocks to minimize Rebound Pain in patients undergoing Shoulder Surgery	Not yet recruiting	Intervention	2022-02-25	<NULL>	<NULL>	5247	Comparative study of the analgesic effectiveness of the uso of Adjuvantes in Peripheral Nerve Blocks to minimize Rebound Pain in patients submitted to Shoulder Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Hospital Universitário do Cajuru - Pontifícia Universidade Católica do Paraná	Hospital de Urgências de Goiânia	https://ensaiosclinicos.gov.br/rg/RBR-48gkx3m	<NULL>	Healthy volunteers; both genders; age above 18 years; physical status classified by the American Society of Anesthesia as I or II	Volunteers with neuropsychiatric disorders, cognitive impairment or mental status changes; users of monoamine oxidase inhibitors or anticonvulsants; with other fractures, injuries or previous surgery on the same operated limb; with paresis or paresthesias of the upper limb of origin different from the main diagnosis; procedures requiring a change in anesthetic technique; volunteers who refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-8v2qmyz	Online rehabilitation of post-COVID-19 patients	Not yet recruiting	Intervention	2022-02-27	<NULL>	<NULL>	5248	Telemonitoring in the rehabilitation of post-COVID-19 patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Santa Catarina	Laboratório de Avaliação e Reabilitação do Aparelho Locomotor	https://ensaiosclinicos.gov.br/rg/RBR-8v2qmyz	<NULL>	Volunteers with post-covid-19 syndrome; with symptoms of fatigue; both genders; age between 18 and 70 years; no physical limitations; able to perform physical effort with grade 1, 2 and 3 classification on the modified medical research council scale;	Volunteers recovered from COVID-19 with no symptoms of fatigue; grade 4 and 5 classification on the modified medical research council scale; miss four telemonitoring sessions in total or more than two consecutive sessions; volunteers who are unable to carry out the proposed activities;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-52h647m	Effect of PRF as a complementary therapy in the treatment of periodontal disease	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5250	Effect of PRF as adjunctive therapy to scaling and root planing in the treatment of periodontitis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia - Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-52h647m	<NULL>	Patients with Stage III Periodontitis, with 5 mm or more of interproximal attachment loss or radiographic bone loss extending to the apical half or third of the root; may have vertical bone loss of up to 3 mm; grade II or III furcation lesions and moderate ridge defect; direct evidence of non-progression of attachment loss for 5 years or indirect evidence of bone loss/year up to 0.25 mm; patients with large accumulation of biofilm but little periodontal destruction; minimum of 20 teeth present and presence of two pairs of contralateral teeth with proximal periodontal sites presenting probing depth and clinical attachment level ≥ 5 mm	Underage patients; patients who do not agree with the informed consent and do not sign it; tooth loss of 5 or more teeth due to periodontitis; positive history of antibiotic therapy in the last six months; positive history of nonsurgical periodontal therapy in the last six months; systemic involvement that may interfere with disease progression or response to treatment; need for antibiotic prophylaxis for routine dental procedures; use of anti-inflammatory drugs for a long period of time; smoking; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9vv26mh	Deep Transverse Massage as a Potentiating Resource in the Treatment of Patellofemoral Pain Syndrome	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5251	Effectiveness of a Protocol Involving Deep Transverse Massage in the Treatment of Patellofemoral Pain Syndrome: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-09	Ingrid Fernanda Andrade Dias	Faculdades Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-9vv26mh	<NULL>	Adults between 20 and 40 years of age; Those with anterior or retropatellar pain in the knee; Physical activity practitioners; Presence of weakness of the muscles of the quadriceps, abductors and external hip rotators	Knee joint surgery; Presence of clinical diagnosis related to the knee (MRI findings of intra-articular pathological conditions involving ligaments or meniscal effusion, subluxation or patellar dislocation); Fracture of the patella or in the knee region; Use of anti-inflammatory drugs; Presence of comorbidities (neoplasms, obesity, neurological diseases, cardiovascular disease and respiratory diseases); Physical therapy at another service	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9k64p2q	The effect of Low Power Laser on Pain reduction, Mouth Opening Difficulty and Swelling after wisdom teeth Removal	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5252	Evaluation of the effectiveness of the Low-powered Laser in reducing Pain, Trissum and Edema after lower third molar Extraction: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Universidade Federal do Ceará - Campus Sobral (UFC)	Universidade Federal do Ceará - Campus Sobral (UFC)	https://ensaiosclinicos.gov.br/rg/RBR-9k64p2q	<NULL>	Patients older than 18 years old, who require extraction of both lower third molars; Patients who are classified by the American Society of Anesthesiology (ASA, from the English American Society of Anesthesiologists) as ASA I.	Patients with the presence of infectious conditions or pathologies associated with third molars that interfere with the clinical parameters of control of the study variables; Patients who have a chronic addiction, such as smoking or drinking; Patients who did not commit to attending at all times in this research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-5tcczr9	Effects of training consisting of different exercise modalities on functional capacity, quality of life and mental health in institutionalized elderly coronavirus survivors	Not yet recruiting	Intervention	2022-03-03	<NULL>	<NULL>	5256	Effects of multicomponent training on functional capacity, quality of life and mental health in institutionalized elderly survivors of Covid-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade Federal do Rio Grande do Sul- UFRGS	Centro Universitário da Serra Gaúcha- FSG	https://ensaiosclinicos.gov.br/rg/RBR-5tcczr9	<NULL>	Institutionalized individuals; age equal to or greater than 60 years; both genders; who had Covid-19 infection	Neurological disease; cardiovascular and respiratory changes; presence of joint or musculoskeletal injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-446krjm	Use of Prebiotic Polydextrose in Periodontitis	Not yet recruiting	Intervention	2022-03-04	<NULL>	<NULL>	5258	Impact of Prebiotic Polydextrose as an Adjunct in the Treatment of Periodontitis and Modulation of Subgingival and Intestinal Microbiomes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-14	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-446krjm	<NULL>	Presence of at least 15 natural teeth, excluding third molars and teeth indicated for extraction; diagnosis of generalized stage III grade A and B periodontitis, with at least 30% of the teeth with at least one site with probing depth and clinical level of insertion greater than or equal to 5 mm and bleeding on probing.	Presence of other systemic conditions which can affect the progression of periodontitis or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and / or use of antimicrobials in the last 6 months; use of probiotics in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; extensive prosthetic rehabilitation; tobacco consumption in the last 5 years; pregnancy and lactation and gastrointestinal diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-6bygmz9	Effect of Virtual Reality on Abdominal Contraction of sedentary young adults: randomized clinical trial	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5259	Effect of Virtual Reality on Central Stabilization of sedentary young adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-18	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-6bygmz9	<NULL>	Age between 18 and 29 years old; male and female individuals; sedentary academics; academics with preserved mental faculties.	Non-prosthetic amputees; academics with vestibular diseases in acute crises; academics with diseases with neuromotor impairment; academics with uncontrolled cardiovascular diseases; academics who practiced physical activities for at least four months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-2mfbkkk	Clinical study of the application of Light Therapy in the treatment of Taste Disorders in post-COVID-19 patients	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5262	Clinical study of the application of Photobiomodulation in treatment of Dysgeusia in post-COVID-19 patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2mfbkkk	<NULL>	Tested positive for coronavirus (COVID-19) after the Reverse Transcriptase Reaction followed by Polymerase Chain Reaction (RT-PCR) examination and who complained of symptoms of dysgeusia; Patients aged 18 years or older; Patients who are not in the disease transmission phase (fifteen days after the onset of symptoms); Patients who accept to be part of the research by signing the Free and Informed Consent Term; Patients who underwent gustatory dysfunction assessment tests and dysgeusia was confirmed	Patients who tested negative for coronavirus (COVID-19) after the Reverse Transcriptase Reaction followed by Polymerase Chain Reaction (RT-PCR) test; No complaints of dysgeusia symptoms; Under 18 years old; Pregnant and/or lactating patients; Patients who do not accept to participate in the research or who do not sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-4kdqcbt	Effect of a two-task exercise in Virtual Reality on the physical and mental point of view in the elderly: a randomized clinical trial	Not yet recruiting	Intervention	2022-03-08	<NULL>	<NULL>	5263	Effect of a Dual Task training in Virtual Reality on physical-functional and cognitive aspects in the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-4kdqcbt	<NULL>	Seniors; Age between 60 and 79 years; both sexes; with cognitive modifications on the Mini Mental State Examination (MMSE)	Inability to understand simple verbal commands; severe visual impairment or not compensated with the use of corrective lenses; serious auditory implications; who have completed any cognitive training program in the past six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-55wqx58	Effects of resistance training on the rehabilitation of athletes submitted to anterior cruciate ligament surgery	Not yet recruiting	Intervention	2022-03-10	<NULL>	<NULL>	5269	Effects of Resistance Training Periodisation on the Rehabilitations of athletes submitted to Anterior Cruciate Ligament: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-55wqx58	<NULL>	Male participants; Age between 18 and 40 years; Patients who underwent anterior cruciate ligament reconstruction;	Regular use of analgesics and/or anti-inflammatory drugs and food supplements; Grade III injury of the medial or lateral collateral ligament; Presence of grade IV chondropathy; meniscal suture; Meniscal injury that requires meniscectomy of a portion greater than 50% of the meniscus; Extra-articular tenodesis; Not wishing to return to sport; Previous knee, hip or ankle surgery; Posterolateral corner injury;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9bp2g4w	Profile of physical activity and depression in people with multiple sclerosis	Not yet recruiting	Intervention	2022-03-13	<NULL>	<NULL>	5274	Assessment of Sedentary Behavior, Physical Activity Level, Depressive Symptoms and Gait in People with Multiple Sclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9bp2g4w	<NULL>	Age between 18 and 60 years; MS diagnosis for more than one year. A score above 4 on the Patients Determined Disease Steps Scale (PDDS) and Expanded Disability Status Scale (EDSS)	Refusal to meet for data collection, previously scheduled	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-6wgwxsy	Comparative search between  HIV medicines  in Covid-19	Not yet recruiting	Intervention	2022-03-14	<NULL>	<NULL>	5275	Randomized double-blind clinical trial comparing Atazanavir + Ritonavir + Doxycycline versus Atazanavir + Ritonavir in patients with laboratory or clinical diagnosis for Covid-19, in the state of Pernambuco and Alagoas – Brazil	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital das Clínicas da Universidade Federal de Pernambuco	Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL	https://ensaiosclinicos.gov.br/rg/RBR-6wgwxsy	<NULL>	outpacients with positive diagnosis for COVID-19	Patients with indication for hospital admission;  patients with other protease inhibitors;  pregnant;  infants;  more than 5 days  from the onset of symptoms, HIV positive patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-22cv4kv	The effect of the World Health Organization&apos;s iSupport in Brazil	Not yet recruiting	Intervention	2022-03-14	<NULL>	<NULL>	5276	Translation, Cultural Adaptation and the Effects of the World Health Organization&apos;s iSupport for the Brazilian Context	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Departamento de Gerontologia da Universidade Federal de São Carlos	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-22cv4kv	<NULL>	Be aged 18 years or older; report that they are a family caregiver of a person with dementia; providing non-paid care for at least 6 months at the time of the recruitment; caring for a person holding a diagnosis of dementia; have access to a smartphone, computer or tablet with internet	Unable to comprehend written Brazilian Portuguese; not having access to a device with internet connection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-7xj4wyp	Evaluation of the use of Telemedicine in Pediatric Intensive Care Units: Randomized Controlled Trial.	Not yet recruiting	Intervention	2022-03-22	<NULL>	<NULL>	5294	Evaluation of the Impact of Telemedicine Use on Clinical Care Indicators in Pediatric Intensive Care Units: Cluster Randomized Controlled Trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde	Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7xj4wyp	<NULL>	All children admitted in the pediatric Intensive Care Unit (ICU) aged  bigger or equal 29 days and smaller 18 years, with a length of stay greater than 8 hours, and in case of death, greater than 24 hours	Patients with incomplete medical records or with incomplete data in the institution&apos;s database; patients whose guardians did not accept to participate in the study and/or who did not sign the Informed Consent Form (FICF) and term of use of image	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-9bv3dc9	Effects of balance strength training to prevent falls in the elderly population with cognitive decline	Not yet recruiting	Intervention	2022-03-25	<NULL>	<NULL>	5303	Effects of instability resistance training for falls prevention in community-dwelling older adults with probable cognitive impairment: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-31	Universidade Federal do Vale do São Francisco - UNIVASF	Universidade Federal do Vale do São Francisco - UNIVASF	https://ensaiosclinicos.gov.br/rg/RBR-9bv3dc9	<NULL>	Participants both sex, male or female, aged 65 and older; are able to walk 10 meters without assistance; present subjective cognitive complaints and / or score less than 26 (of a total of 30 points) in Montreal Cognitive Assessment (MoCA); live independently in the community; and be able to read, write, speak and understand in the Portuguese language	Be engaged in structured exercise (e.g. aerobic, resistance or mind-body exercise classes) in the last three months; have had a clinical condition that interferes with exercise (e.g., angina pectoris); have had a previously diagnosed cardiovascular (e.g., stroke), neurodegenerative (e.g., Parkinson’s disease) or psychiatric (e.g., major depression) disease; have severe musculoskeletal or vestibular disorders; or are unable to complete the assessments or intervention due to inadequate vision and/or hearing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-8zbys7m	Metabolic profile of frail and pre-frail elderly women and its response to exercise	Not yet recruiting	Intervention	2022-03-28	<NULL>	<NULL>	5308	Metabolomic profile of frail and pre-frail elderly women and its chronic response to exercise: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Faculdade de Educação Física da Unicamp	Faculdade de Educação Física da Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-8zbys7m	<NULL>	Women over 65 years old	Engaging in exercise programs in the six months preceding the beginning of the experimental design; consumption of nutritional supplements and anabolic steroids in the six months preceding the beginning of the experimental protocol; adherence to restrictive diets; nephropathies, hyper or hypothyroidism, cancer, or obstructive lung disease; untreated arterial hypertension; diabetes mellitus; body mass index greater than 35 kg / m2; smoker; cognitive impairment; any cardiovascular, neurological or musculoskeletal problem that makes physical exercise unfeasible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-73yp7vc	Immediate and medium-term effect of photobiomodulation on vocal fatigue in professionals of the voice	Not yet recruiting	Intervention	2022-03-28	<NULL>	<NULL>	5309	Immediate and medium-term effect of photobiomodulation on vocal fatigue in professionals of the voice	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-73yp7vc	<NULL>	Professional voice men and women; with vocal fatigue complaint; with a clinical diagnosis of behavioral dysphonia; age group from 18 to 45 years	Volunteers under the age of 18 and over 46; that present in the vocal folds; phonotraumatic injuries; organic; neurological changes; previous laryngeal surgeries; vocal fold hemorrhages at the time of evaluation; upper airway infections in the last 2 weeks, active tumor processes; who were previously submitted to speech therapy in the voice area; active smokers; pregnant women; menopausal women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-4wtq84v	Auriculotherapy in the treatment of gestational nausea and vomiting: a randomized clinical trial	Not yet recruiting	Intervention	2022-01-13	<NULL>	<NULL>	5312	Technological innovations and integrative and complementary therapies in obstetric care	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4wtq84v	<NULL>	"Pregnant women referred to the AEHU (Ambulatório de Especialidades do Hospital Universitário) from prenatal care at usual risk will be included, and pregnant women at usual risk attended at the basic health units of the network of the city of Londrina, Paraná, with chronological age over 18 years old; gestational age between 5 and 16 weeks confirmed by ultrasound, regardless of parity, who report symptoms of nausea and/or vomiting of a mild degree (PUQE score less than 6) or moderate (PUQE score between 7 and 11)
*PUQE: (Pregnancy Unique Quantification of Emesis)"	Pregnant women with diagnosed mental retardation and suicidal idealization will be excluded; coagulation disorders; in pharmacological treatment for psychosomatic illness such as anxiety and depression; hyperthyroidism; dermatological lesion in the pinna; unexplained fever; multiple pregnancy; gestational trophoblastic disease, hyperemesis gravidarum; use of antiemetic; diarrhea; pregnant women with fetuses with Down syndrome, and pregnant women afraid to receive the semi-permanent needle	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-559x2b3	Effectiveness of electroacupuncture and laseracupuncture in the health of post-covid-19 patients: randomized clinical trial	Not yet recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5319	Effectiveness of electroacupuncture and laseracupuncture in the health of post-covid-19 patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-559x2b3	<NULL>	Age between 18 and 59 years; history of positive testing for SARS-Cov-2; with new or persistent symptoms since the acute phase of the disease lasting at least two months, unexplained by an alternative diagnosis; that has one or more of the following characteristics: altered spirometry parameters; fatigue score greater than 4; anxiety score equal to or greater than 11; score on the depression scale equal to or greater than 8; not having a contraindication factor for performing electroacupuncture and laseracupuncture; not being on specific clinical treatment for the post-COVID-19 syndrome; present agreement with the Free and Informed Consent Form signed in two copies; agree to participate in the proposed tests.	Institutionalized people; who do not present the signature of the Free and Informed Consent Form; who do not fit into the aforementioned age group; history of carcinoma; neoplasms; physical disability; motor and/or cognitive; use of metallic prostheses; pacemaker; photosensitivity history; contraindication for the use of photobiomodulation (melanin changes; history of burns); current treatment/follow-up other than usual care. Pregnant women, people with severe mental disorders, risk of suicide attempt, people with hormonal disorders, people who are under any therapeutic intervention of traditional Chinese medicine will also not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-26bhg4z	Cognitive Therapy Based on Mindfulness and Treatment Resistant Depression: A study comparing two groups	Not yet recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5322	Mindfulness-based cognitive therapy and Depression resistant to treatment: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-26bhg4z	<NULL>	Participants aged 18 or over; major depressive disorder according to the DSM-V criteria; a score equal to or greater than 18 points on the Hamilton Depression Scale (HAM-D17)	without diagnosis of major depressive disorder DSM-V criteria; diagnosis of schizophrenia or other psychotic symptoms; meet the DSM-V criteria for alcohol or substance abuse or addiction within 3 months before entering the study; had been practicing meditation or yoga for at least two months; have cognitive impairment (score &lt;22 on the MMSE); are in individual or group psychotherapy and are not willing to discontinue treatment for the duration of 8 weeks of study treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-4ttd9yc	Use of anti-inflammatory eye drops after laser therapy for glaucoma treatment	Not yet recruiting	Observational	2022-04-04	<NULL>	<NULL>	5327	Use of anti-inflammatory eye drops after selective laser trabeculoplasty: a randomized clinical trial	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-05-01	Hospital Oftalmológico de Brasília	Hospital Oftalmológico de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4ttd9yc	<NULL>	Patients with primary open-angle glaucoma or ocular hypertension or pseudoexfoliative glaucoma or pigmentary glaucoma or pigment dispersion syndrome, with inadequate control of intraocular pressure or intolerance to topical treatment, that will undergo selective laser trabeculoplasty (SLT). Patients approached must be at least 18 years of age on the date of the procedure and be able to undergo post-SLT follow-up for at least 12 months	Angle-closure glaucoma; Any previous glaucoma surgery; Any previous corneal procedure (refractive surgery, intrastromal rings, corneal transplant); Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-4bhmm7y	CBD/THC solution as a pharmacological strategy for patients with fibromyalgia (FibroCann)	Not yet recruiting	Intervention	2022-02-23	<NULL>	<NULL>	5328	CBD/THC solution as a pharmacological strategy for patients with fibromyalgia: single-center, double-blind, randomized, placebo controlled clinical trial protocol (FibroCann)	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-04-15	FG Brasil LTDA	3F Clinical Trials LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4bhmm7y	<NULL>	Previous diagnosis of fibromyalgia based on the pharmacological criteria of the American College of Rheumatology, 2016 to fibromyalgia, having received three months of pharmacological treatment without relevant clinical improvement; Adult individuals (aged 18 to 75 years) with a mean pain intensity greater than or equal to 7 on the FIQ numerical pain scale (Fibromyalgia  Impact Questionnaire); No use of Cannabis or its derivatives (THC and CBD) in any systemic administration route in the last six months; Capability to read, write and speak in Portuguese (Brazil); Sign the ICF (Informed Consent Form).	Pregnancy or breastfeeding; Any known pathology, in an advanced stage, associated with the locomotor system (arthritis, osteoarthritis, uric acid); Neurological disorders; Previously reported renal disorders or changes in the exams during the pre-randomization stage; Previously reported liver disorders or changes in tests during the pre-randomization stage; Peripheral neuropathy; Known serious cardiovascular disease (uncontrolled hypertension, heart failure, cardiac pacemaker); Medical decision that participation in the study is not in the best interest of the patient; Making previous use of cannabinoids by any route of administration; Diagnosis of alcohol dependence; Usage of psychotomimetic drugs or narcotics; Having participated in research projects in the two months prior to the beginning of the study; Having a history or having first-degree relatives with a history of psychosis in any level at least once in their lifetime; Inappropriate metabolic profile of THC or CBD cannabinoids for the use of the test doses in this study, observed  by pharmacogenetic testing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-9c7pkd8	Efficacy of a Health Education Program on physical activity and food consumption in schoolchildren	Not yet recruiting	Intervention	2022-04-08	<NULL>	<NULL>	5333	Efficacy and effectiveness of a Health Education Program regarding the practice physical activity and food consumption in schoolchildren in a southern Brazilian county: a controlled community trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-06-20	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-9c7pkd8	<NULL>	All high schools in the state public network in the municipality of Rio Grande will be included in the Health Education Program; schoolchildren of both sexes aged between 14 and 17 years old and duly enrolled; first year high school students	Students who have physical and or cognitive limitations that prevent them from completing the self-administered questionnaires and performing the physical assessments will be excluded; students who are in the gestational period or who are breastfeeding; schoolchildren outside the age group of 14 to 17 years; students who do not reach a minimum attendance of fifty percent in the activities proposed by the Health Education Program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-3tkjtpw	Use of a mobile application for professional management and communication and use of a game through virtual reality at the beginning of recovery after stroke	Not yet recruiting	Intervention	2022-04-08	<NULL>	<NULL>	5334	Use of an Application as a Management and Professional Communication tool and use of a Serious Game through non-Immersive Virtual Reality in the Initial Phase of Rehabilitation after Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3tkjtpw	<NULL>	Patients diagnosed with ischemic and hemorrhagic stroke 24 hours after the injury; both sexes; older than 18 years; able to remain seated without support; ability to move the affected limb against gravity (specifically, shoulder flexor and abductor muscle groups, elbow flexor-extensor muscles, and fingers)	Patients with previous stroke; partial or total anopsia; cognitive deficits; coordination disorders in the upper limb; amputation at any level of the affected upper limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-2z27nc9	Clinical study to evaluate the perceived safety and efficacy, under normal conditions of use, of the unflavored denture fixative cream product by evaluating the acceptability in the oral mucosa	Not yet recruiting	Observational	2022-04-12	<NULL>	<NULL>	5340	A clinical trial to evaluate the safety of the investigational product denture fixing cream without flavor , evaluating the acceptability in the oral mucosa and perceived efficacy under normal conditions of use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-25	Kosmoscience Ciência e Tecnologia Cosmética Limitada	Cimed Industria Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-2z27nc9	<NULL>	Age range between 18 and 60 years. Female and male. Phototype (Fitzpatrick): I to VI. Being a user of removable dental prostheses (dentures). Be a user of products of the same category. Agree on procedures and requirements during study use: study time (after 21 days) laboratory to perform investigational product home study procedures, change the product study diary, do not change the study product study diary. Agree to perform facial aesthetic dermatological treatments until the end of the study (21 days), such as: peelings, laser, fillers, use of any unusual suitable products	Pregnant or lactating women. Participant who belongs to the risk group for COVID-19, that is, with cardiovascular, renal and chronic respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group. Presence of dermatoses, active skin lesions (local and/or disseminated) or irritation in the mouth region (internal or external). Expected vaccination during the study or up to 3 weeks before the study. History of oral pathologies. Use of non-steroidal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study. Be participating in another study in the same application region. History of non-adherence or unwillingness to adhere to the study protocol. Being undergoing dental treatment. Not taking vitamin A or derivatives. Any condition that, in the opinion of the researcher, could compromise the study. (To describe)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-25dnqsk	Health economic outcomes of the medication reconciliation service in the pediatric sector of a high-complexity public hospital: A Randomized Clinical Trial	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5347	Trials on the costs of medication reconciliation in pediatrics at a high-complexity public hospital	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-15	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-25dnqsk	<NULL>	Patients admitted to hospital; stay in hospital for at least 24 hours; children who are from 0 days to 12 years of age and that the caregiver or guardian signs the Informed Consent Form or the Informed Assent Term	Readmitted patients; those who do not consent to participate; those who are discharged within 24 hours of admission; when counseling is not possible, as stated by the care or patient due to physical or mental restrictions, severity of illness or language restrictions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-6sm7n2w	The additional effect of electrotherapy in patients with shoulder tendinitis	Not yet recruiting	Intervention	2022-04-18	<NULL>	<NULL>	5349	The Additional Effect of Percutaneous Microelectrolysis in patients with rotator cuff Tendinopathy : a controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-10	Geraldo Carvalho Magalhães	Hospital Universitário Alcides Carneiro	https://ensaiosclinicos.gov.br/rg/RBR-6sm7n2w	<NULL>	Men and women aged or older than 18 years; complaint of persistent pain in one or both shoulders for the past 3 months; clinical and imaging diagnosis of tendinopathy of any of the rotator cuff muscles	People with absolute or relative contraindication to MEP ( Percutaneous Microelectrolysis); diagnosis of rheumatologic, systemic or neurodegenerative diseases causing shoulder pain such as rheumatoid arthritis, sickle anemia or stroke hemiparesis; shoulder surgery history; history of corticosteroid infiltration treatment performed within the last 2 months; having other pathological conditions of a traumatic-orthopedic nature such as adhesive capsulitis, traumatic lesions of the labrum and fractures in the shoulder complex	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-4d93q84	Effect of active storytelling methodology on learning about the Unified Health System	Not yet recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5351	Effect of storytelling on learning about the history and institutionalization of the Unified Health System: a randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4d93q84	<NULL>	students regularly enrolled in the 2nd period of the course; older than 18 years.	students expected to leave for the next 15 days; students who have already participated in the previous assessment of the instrument (in any of the previous stages of the study); not completing the data collection instrument completely; non-participation in the second application of the post-test that will occur on the 15th day after the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-7cdwqzk	Forrotherapy: Effect of a procedure adapted from dance training on the conditions and quality of life of elderly people in the community	Not yet recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5353	Forrotherapy: Effect of a protocol adapted from a functional training through dance on the quality of life and the physical-functional aspects of the elderly in the community: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-18	Centro Universitário CESMAC (Centro de Estudos Superiores de Maceió)	Centro Universitário CESMAC (Centro de Estudos Superiores de Maceió)	https://ensaiosclinicos.gov.br/rg/RBR-7cdwqzk	<NULL>	Elderly; both sexes; age equal to or greater than 60 years; preserved cognition; preserved mobility capacity.	Elderly people with paraplegia; totally dependent on walking aids; has dementia and severe attention deficit that makes it impossible to understand to respond to a simple verbal command. any orthopedic, rheumatologic or neurological alteration that makes independent walking impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-33t6s52	The effect of Transcranial Direct Current Stimulation in pain control in patients with Rheumatoid Arthritis	Not yet recruiting	Intervention	2022-04-25	<NULL>	<NULL>	5361	Transcranial Direct Current Stimulation in pain control in patients with Rheumatoid Arthritis: a randomized, placebo-controlled, double-blind, phase II clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal do Amazonas	Fundação Hospital Adriano Jorge	https://ensaiosclinicos.gov.br/rg/RBR-33t6s52	<NULL>	Adult volunteers (higher than 18 years) diagnosed with Rheumatoid Arthritis; both genders; with chronic pain longer than 12 weeks or 3 months; with a pain level greater than 7 by the visual analog scale of Pain and who are using synthetic disease-modifying drugs	Volunteers who are using biological disease-modifying drugs; who have neuropsychiatric diseases; who have a history of illicit drug use and abuse; who have neurological, cognitive, or motor deficits; who underwent neurosurgical interventions (craniotomy); who have a clinical diagnosis of severe depression with more than 30 points according to the Beck Depression Inventory tool; who have a history of seizures and/or epilepsy; who are using high doses of opioids (more than 30 mg of Oxycodone, Hydrocodone or 7.5 mg of Hydromorphone or equivalent drug); pregnant women; who have metallic implants in the cranial and/or facial region; who use a pacemaker; with a history of skin diseases; who have other autoimmune diseases not related to Rheumatoid Arthritis; who have cancer diseases; who have disease in the decompensated phase (ischemic heart disease, kidney and/or liver diseases)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-2gq7mqr	Acupuncture in muscle fatigue	Not yet recruiting	Intervention	2022-03-29	<NULL>	<NULL>	5362	Effect of acupuncture on muscle fatigue	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-03	Faculdade Motricidade Humana	Faculdade Motricidade Humana	https://ensaiosclinicos.gov.br/rg/RBR-2gq7mqr	<NULL>	Healthy men; aged between 18 and 30 years; practicing regular physical exercise, at least twice a week	Recent lower limb injuries; lower limb prosthesis; Body Mass Index &gt;25; use of muscle myorelaxant; needle phobias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-7s8qnjj	Effect of Botulinum Toxin Type A on neuromuscular adaptations in individuals with muscle stiffness after Stroke	Not yet recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5364	Effect of Botulinum Toxin Type A on neuromuscular plasticity in individuals with spasticity post-Stroke	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2022-05-09	Universidade Federal do Rio Grande do Sul -UFRGS	Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul- PUCRS	https://ensaiosclinicos.gov.br/rg/RBR-7s8qnjj	<NULL>	individuals over 18 years of age; of both sexes; who have suffered a stroke; incident time greater than 12 months; ability to walk with or without crutches/canes; presence of spasticity in the ankle plantarflexor muscles	Individuals in rehabilitation or any treatment of a kinetic-functional nature; individuals who have already applied botulinum toxin for less than six months; history of surgical procedure or use of orthopedic prosthesis; presence of neurological disease or dementia; cognitive alteration that prevents understanding of the research; presence of joint or musculoskeletal injury of an inflammatory nature	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-46kpjkm	Momentary and long-term effects of different walking intensities on the psychological elements of the elderly	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5366	Acute and chronic effects of different intensities of aerobic exercise on the psychological aspects of the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-04	Programa de Pós Graduação em Ciências da Saúde da Universidade Comunitária da Região de Chapecó	Programa de Pós Graduação em Ciências da Saúde da Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-46kpjkm	<NULL>	Elderly people in the city of Chapecó aged over 60 years. Classified as insufficiently active by the reduced IPAQ version VIII. Who have a minimum score on the Mini-Mental State Examination (MMSE). Until reaching the number of elderly people resulting from the sample calculation plus loss estimate	Participants who do not have a minimum frequency of 75% in the program.  Who have changes in levels of physical activity during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-8qnmdpm	Pelvic muscle training associated with the use of pessaries in the treatment of pelvic organ fall: Randomized clinical trial	Not yet recruiting	Intervention	2022-04-28	<NULL>	<NULL>	5369	Pelvic floor muscle training associated with the use of pessaries in the treatment of pelvic organ prolapse: Randomized clinical trial	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2022-05-16	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8qnmdpm	<NULL>	Women with pelvic organ prolapse; staging equal to or greater than two; present intact vaginal mucosa and prolapsed region; are without signs and / or symptoms of urinary tract infection; without vaginal infections	Women whose insertion of the pessary was not successful; women with a modified Oxford score less than two	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-4p29wg5	Effects of Osteopathy and Ankle Self-Mobilization on Athlete Ankle Range of Motion Gain	Not yet recruiting	Intervention	2022-04-28	<NULL>	<NULL>	5371	Effects of Osteopathic Manipulative Treatment versus Talocrural Automobilization on Ankle Mobility and Functionality in Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	UDF - Centro Universitário do Distrito Federal	UDF - Centro Universitário do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-4p29wg5	<NULL>	Athletes who practice soccer, running, crossfit or any other modality that generates joint impact in the execution of their movements; practitioner of the modality with training frequency of at least three times a week; Age between 18 and 40 years; Possess reduced active range of motion (ROM) of ankle dorsiflexion (less than 20 degrees of ROM for dorsiflexion in one or both ankles), either in open kinetic chain (OCC) or chain closed kinetics (CCF)	Acute or chronic muscle, ligament, joint and/or tendon injuries; Use of lower limb prostheses; Congenital orthopedic and neurological injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-2jbsf3j	Video exercise sessions for healthy people	Not yet recruiting	Intervention	2022-05-10	<NULL>	<NULL>	5387	Video containing physical exercise sessions to improve the physical activity level of healthy adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2jbsf3j	<NULL>	Adult individuals aged between 18 and 64 years will be included; with absence of comorbidities, physical mobility problems and/or changes in the cognitive level; not be performing physical activity at the moment; and have the ability to speak and understand the Portuguese language	Participants who did not perform the assessments of primary and secondary outcomes before and after the intervention and those who were not cleared by the physician to perform physical exercise will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-4gwpvmr	Study of the implementation of integrative practices in a tertiary hospital in the city of São Paulo	Not yet recruiting	Intervention	2022-05-11	<NULL>	<NULL>	5389	Implementation of the Integrative Pediatrics Unit at the Children and Adolescents Institute (ICr) of the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo (HC-FMUSP)	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4gwpvmr	<NULL>	This implementation study will include one pediatric inpatient unit of medium and high complexity of the Instituto da Criança e do Adolescente, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo; with a multidisciplinary team; number of beds less than 20	Not being a pediatric inpatient unit of medium and high complexity at the Instituto da Criança e do Adolescente of the Hospital das Clínicas, Faculty of Medicine, University of São Paulo; not having a multidisciplinary team; with a number of beds over 20	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2svpc94	Efeito of a digital game on physical activity and diet in adolescents	Not yet recruiting	Intervention	2022-05-12	<NULL>	<NULL>	5392	Impact of a digital game on physical activity and eating habits in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-21	Universidade Federal do Paraná	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-2svpc94	<NULL>	Volunteers healthy, with no health problems that prevent them from practicing physical activity; aged between 10 and 14 years old; enrolled in elementary school II (6th to 9th grade); have a minimum class attendance of 75%; have a Free and Informed Consent Form signed by parents or guardians before the beginning of the interventions; sign the Free and Informed Consent Form; have their own smartphone for the intervention.	Volunteers who withdraw from the research; do not adapt to the use of the exergame.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-5328h8g	Effect of high and low volume of specific training for the trunk in chronic low back pain	Not yet recruiting	Intervention	2022-05-13	<NULL>	<NULL>	5394	Neuroimmunoendocrine effects of core stabilization training in women with chronic non-specific lumbar pain: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5328h8g	<NULL>	Women with a clinical diagnosis of chronic nonspecific low back pain; age between 18 and 59 years; complaint of low back pain for more than 3 months; pain level greater than 3 on the 11-point numerical pain scale; body mass index (BMI) &lt;30 kg/m2; not having undergone spinal surgery; not practicing physical exercise regularly; not having physical therapy or other pain treatment; not taking analgesic, anti-inflammatory, opioid or immunosuppressive medication	Missing one of the assessments; missing more than 10% of the intervention; have any motor, psychiatric or cognitive impairment; have hearing, visual or communication disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2wdjcdv	The Klivo Intervention Program: a digital platform to monitor patients with type 2 diabetes mellitus	Not yet recruiting	Intervention	2022-05-17	<NULL>	<NULL>	5396	The Klivo Intervention Program protocol: management of type 2 diabetes mellitus through a digital platform	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Klivo Licenciamento Ltda.	Klivo Licenciamento Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-2wdjcdv	<NULL>	Diagnosis of type 2 diabetes mellitus in the electronic medical record of health plans and healthcare provider organizations (HbA1c reading 7% or higher; aged between 18 and 65 years). Willingness to receive phone calls and messages for monitoring the disease and for tele-education. Willingness to use the standard monitoring devices (glucometer), synchronized with the telemonitoring system according to the study protocol throughout the 12-month study period.	Cognitive impairment based on a diagnosis of dementia or mild cognitive impairment reported in the medical records. Self-declared reluctance to receive phone calls or messages for disease management. Pre-existing condition: chronic kidney disease stage 5; individuals with any end-stage disease with a life prognosis of fewer than two years; or pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-8q6z6kq	Effect of Bach Flower treatment on hope and quality of life in patients with Advanced Cancer	Not yet recruiting	Intervention	2022-05-19	<NULL>	<NULL>	5400	Effectiveness of Bach Flower therapy on hope and health-related quality of life of patients with Advanced Cancer: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Leonel dos Santos Silva	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8q6z6kq	<NULL>	Be over 18 years old; have a histologically proven diagnosis of any type of advanced (stage IV) cancer; Eastern Cooperative Oncology Group (ECOG): 0, 1, 2 or 3 characterized as: 0 (fully active); 1 (restricted from strenuous physical activity and able to perform work of a light or sedentary nature); 2 (self-care capacity without working conditions, remains out of bed 50% of the time) and 3 (limited self-care capacity, remains 50% of the time in bed or chair rest)	Continuous use of anxiolytic and antidepressant medications; use of some integrative or complementary health practice such as flower essences, chromotherapy, aromatherapy, acupuncture, reiki, therapeutic touch, among others; unable to maintain verbal and/or written communication by the assessment of the Eastern Cooperative Oncology Group (ECOG) 4 performance scale (completely limited and unable to perform self-care activities, totally confined to bed or chair)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-4yjvpxg	Effects of a Group Intervention to prevent Post-traumatic stress disorder linked to childbirth: a comparative study between two groups of high-risk pregnant women	Not yet recruiting	Intervention	2022-05-23	<NULL>	<NULL>	5401	Evaluating the effectiveness of a Brief Intervention for Post-traumatic stress disorder associated with childbirth/birth: a clinical, randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-04	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4yjvpxg	<NULL>	The pregnant women must be 18 years of age or older; being in the third trimester of pregnancy (between 28 and 32 weeks of gestation); no history of previous (self-reported) mental disorders, except for common mental disorders and current ones (score on the Self Report Questionnaire less than 7), score on the Health Questionnaire of the Patient-9 less than 10 and General Anxiety Disorder Questionnaire-7 score less than 10; not being in psychological and psychiatric treatment at the time of data collection; and agree to voluntary participation in the study, signing the Free and Informed Consent Form	Women who drop out of the study at any stage of data collection before the conclusion of the same; do not attend the sessions for the application of the assessment instruments or the meetings of the intervention group, regardless of the reason; and are not found after the pregnancy is resolved by the telephone and/or e-mail provided by them for the evaluation of outcomes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-8cb536g	Effects of Omega-3 Supplementation, associated or not with Physical Exercise in patients with Metabolic Syndrome	Not yet recruiting	Intervention	2022-05-24	<NULL>	<NULL>	5402	Effects of Omega-3 Supplementation, associated or not with High-intensity Physical Training on anthropometric, physiological, biochemical and molecular parameters in patients with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8cb536g	<NULL>	Both sexes; age between 20 and 60 years; diagnosis of grade I obesity (Body Mass Index between 30.0 and 34.9 kg/m²) and type 2 diabetes mellitus; exclusive use of metformin; no evidence of coronary artery disease (history of angina, history of myocardial infarction or acute coronary syndrome, history of abnormal segmental motion of the heart wall on echocardiography); no bowel disease (short bowel syndrome, irritable bowel syndrome, Chron&apos;s disease, ulcerative colitis, celiac disease, colorectal cancer); no diseases related to the central nervous system (Alzheimer&apos;s, Parkinson&apos;s, hepatic encephalopathy, autism spectrum disorders); physical inactivity according to the International Physical Activity Questionnaire (short version); signing the informed consent form (ICF).	Individuals with musculoskeletal or cardiovascular limitations that make physical exercise impossible; fasting blood glucose greater than 300 mg/dl; use of any drug of continuous use for less than 3 months (except metformin); use of antibiotics, non-steroidal anti-inflammatory drugs or corticosteroids in the last month; use vitamin/food supplements that contain omega-3; individuals with genetic and hormonal limiting disease; abuse of alcohol and drugs; retinopathy; pregnancy or lactation; life expectancy less than 6 months (example: metastatic malignant neoplasm); patients with renal failure or congestive heart failure; individuals with previous organ transplants; wheelchair users; individuals with weight loss in the last 3 months (voluntary or not); volunteers in another experimental study on the date of enrollment; individuals who do not have access to the internet; discontinuation of omega-3/placebo use for 3 consecutive days; non-compliance with the physical activity protocol for 2 consecutive sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2znphfj	Efficacy of Acupuncture in the pinna to reduce Anxiety in Primary Health Care professionals	Not yet recruiting	Intervention	2022-05-26	<NULL>	<NULL>	5406	Efficacy of Auriculotherapy to reduce Anxiety in Primary Health Care professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-06	Anny Caroline Santos Almeida	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2znphfj	<NULL>	All PHC health professionals in the city of Lagarto Sergipe. Assent to participation by means of a Free and Informed Consent Term. Have moderate or severe levels of anxiety, according to the State Trait Anxiety Inventory	Professionals with scheduled vacations during the research period. On sick leave. pregnant women Allergic to tape and micropore. Those who at the time of the study are using anxiolytics focus on the treatment of anxiety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-10s75n9x	Evaluation of the use of the COVISTIX/COVIMARK rapid test for identification of COVID-19 virus (coronavirus) by lay people	Not yet recruiting	Intervention	2022-05-27	<NULL>	<NULL>	5408	Usability evaluation of the rapid SARS-CoV-2 antigen detection self-test (COVISTIX/COVIMARK) by lay subjects	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	CAEP - Centro Avançado de Estudos e Pesquisas	CAEP - Centro Avançado de Estudos e Pesquisas	https://ensaiosclinicos.gov.br/rg/RBR-10s75n9x	<NULL>	Cohort A - Adult subjects over 18 years old, of both sexes; be able to sign the ICF approved by the EC and to execute and understand all the procedures and instructions of the study; presenting suspected flu-like symptoms of COVID-19 with an onset of 5 days or less; or having had contact with a person infected with SARS-CoV-2 within 14 days; Cohort B - Adult subjects over 18 years of age, of both sexes; be able to sign the ICF approved by the EC and execute and understand all assay procedures and instructions; previous positive test for COVID-19 less than 2 days; if the subject is symptomatic for COVID-19, the symptoms are of mild to moderate intensity; be immunized with at least two doses of the COVID-19 vaccine; availability of maintaining isolation for up to 9 days from the signing of the ICF, to perform the self-test at home and home collection of RT-PCR for SARS-CoV-2 at the end of the study; be able to photograph the cassettes with the test result and sending the images to the research center, daily	Cohort A - Present a diagnosis of COVID-19 with symptoms of severe acute respiratory syndrome; presence of nasal obstruction that prevents swab collection; participation in a clinical trial in the previous twelve months; any condition that, in the investigator&apos;s judgment, precludes participation for reasons of subject safety or data integrity; Cohort B - Having a negative result in the self-test with COVISTIX/COVIMARK during the selection visit; being immunocompromised or using an immunosuppressant; having chronic diseases such as diabetes, hypertension, asthma, chronic obstructive pulmonary disease, obesity; having a diagnosis of COVID-19 with symptoms of severe acute respiratory syndrome; presence of serious symptoms or symptoms that require hospital care; previous positive test for SARS-CoV-2 infection or confirmed diagnosis of COVID-19 more than 2 days; being hospitalized or requiring hospitalization; inability to maintain isolation for up to 9 days after signing the ICF, for conducting the self-test at home and collecting a nasal swab at home of RT-PCR for SARS-CoV-2 at the end of the study; inability to photograph cassettes with test results and send the images to the study center daily; presence of nasal obstruction that prevents swab collection; - participation in a clinical trial in the previous twelve months; any condition that, in the investigator’s judgment, precludes participation for reasons of subject safety or data integrity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-6vbfszv	Analysis of Syringe Identification Pattern for Medication Administration during Anesthesia and its association with medication errors	Not yet recruiting	Observational	2022-06-01	<NULL>	<NULL>	5414	Analysis of Syringe Identification Pattern for Drug Administration during Anesthesia in Brazil and its association with medication errors in the perioperative period	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-12	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6vbfszv	<NULL>	Training anesthesiologists will be included; as well as those already trained; of public and private hospitals in different Brazilian regions	Anesthesiologists who refuse to sign the consent form or who show prior knowledge of the study to be carried out will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-7p8wzyr	Use of video games and conventional physical therapy to improve balance and postural control in patients with knee arthrosis: a randomized clinical trial	Not yet recruiting	Intervention	2022-06-11	<NULL>	<NULL>	5428	Virtual reality and kinesiotherapy for improving balance and postural adjustments in patients with knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-10	Universidade Federal do Pará	Associação das Pioneiras Sociais	https://ensaiosclinicos.gov.br/rg/RBR-7p8wzyr	<NULL>	Female and male individuals, aged at least 18 years and diagnosed with knee osteoarthritis will be included.	Those who have a previous history of orthopedic surgery, fractures, neurological diseases, self-reported cognitive impairment that affects collection procedures, pregnancy, loss of protective foot sensitivity, individuals who are not clinically stable and who have contraindications to exercise will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-10k3pkd2	Study of the effects of Aerobic Physical Training on blood pressure and heart rate in men who had Covid-19	Not yet recruiting	Intervention	2022-06-21	<NULL>	<NULL>	5435	Study of the effect of Aerobic Physical Training on cardiorespiratory and metabolic parameters in individuals affected by Covid-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Faculdade de Medicina de Ribeirão Preto	Universidade de Franca - Unifran	https://ensaiosclinicos.gov.br/rg/RBR-10k3pkd2	<NULL>	Men and women; aged between 30 and 55 years; affected by Covid-19 in the mild form of the disease (treated at home); and in the severe form of the disease (required hospitalization); individuals who present any symptoms of the disease such as dyspnea; fatigue; respiratory and/or skeletal muscle weakness; among others.	Men and women who are in the period of transmission of the Covid-19 disease or who are undergoing previous home or outpatient physical therapy treatment; individuals with a cognitive disorder that prevents them from understanding the tests and training; musculoskeletal changes that make it impossible to perform tests and aerobic physical training; hemodynamic instability or that evolved with arrhythmias; smokers or who use drugs that interfere with cardiac functionality and cardiovascular autonomic control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-7tr9sbx	Efficacy potential of a behavioral intervention to promote adherence to oral antidiabetic drugs	Not yet recruiting	Intervention	2022-06-23	<NULL>	<NULL>	5441	Efficacy potential of a behavioral intervention to promote adherence to oral antidiabetic drugs	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de São João del Rei	Universidade Federal de São João del Rei	https://ensaiosclinicos.gov.br/rg/RBR-7tr9sbx	<NULL>	People with type 2 diabetes mellitus; 18 years of age or older; who have been using oral antidiabetic drugs for at least six months; are undergoing health monitoring in a health unit; with positive intention (greater than or equal to 4) to perform oral antidiabetic taking behavior; that have the ability to establish effective communication.	People who use insulin concomitantly with oral antidiabetics; that the administration of the medication is carried out by a caregiver.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5cr6ngd	Laser Ear Acupuncture to treat jaw joint changes	Not yet recruiting	Intervention	2022-06-24	<NULL>	<NULL>	5444	The effect of Laser Auriculotherapy for the treatment of Temporomandibular Dysfunction: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-20	Sara Lisboa Marques	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5cr6ngd	<NULL>	"Presence of temporomandibular disorder confirmed by the Diagnostic Criteria for Temporomandibular
Disorders DCTMD; age group from 18 to 50 years; availability to attend the research site during the study period"	Use of piercing or birthmark; history of neoplasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-10rv3fqt	Suspension training and chronic low back	Not yet recruiting	Intervention	2022-06-27	<NULL>	<NULL>	5447	Comparison of the effects of two suspension training protocols on pain and skeletal muscle function of individuals with  chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10rv3fqt	<NULL>	chronic nonspecific, persistent or periodic low back pain for more than three months; 18 and 60 years of age;  pain with a Numerical Pain Scale greater than 3 on the day of assessment; be classified as at least moderately active according to the Human Activity Profile Questionnaire.	"pregnant women; lactating women; sedentary individuals; Body Mass Index (BMI) greater than or equal to 30 kg/m2; without physical therapy treatment simultaneously with the study period; surgery in the lumbar region; without clinical diagnosis of low back pain; not present low back pain radiating to the glutes and lower limbs; sensory alteration in the lower limbs and the use of medication to relieve low back pain 48 hours before the performance of the exercises;  neurological disease, previous 
diagnosis of heart disease, acute lung disease, pregnant women, uncontrolled hypertension beginning of medication use less than 1 year ago), orthopedic injuries."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-9szgmpp	Deep Heat Application in Women with Fibromyalgia	Not yet recruiting	Intervention	2022-07-04	<NULL>	<NULL>	5461	The effects of Radiofrequency in patients with Fibromyalgia: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Instituto de Neurologia, Neurocirurgia e Comportamento	Universidade Federal do Amazonas - Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-9szgmpp	<NULL>	Women; over 18 years of age; with fibromyalgia; one year of diagnosis; accepted to participate in the intervention	Women with metallic implants at the application site; with sensitivity alterations at the application site; with silicone prostheses; with a cardiac pacemaker; with neoplasms; with acute inflammatory processes; who are pregnant; with ischemic tissues; with tuberculous lesions; who have had recent deep vein thrombosis; with hemorrhagic conditions or the likelihood of this occurring; with heart disease; with decompensated blood pressure; who have attendance lower than 75% at the appointments/treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-738zkp7	Effects of cerebral stimulation during treadmill training on gait in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2022-07-04	<NULL>	<NULL>	5462	Effects of transcranial direct current stimulation combined with treadmill training on gait in people with Parkinson&apos;s disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro	Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro	https://ensaiosclinicos.gov.br/rg/RBR-738zkp7	<NULL>	Subjects with diagnosis of idiopathic Parkinson&apos;s disease given by a private neurologist, according to the London Brain Bank criteria.	Subjects with another neurological disease in addition to Parkinson&apos;s disease; subjects in stage above of 3 on the adapted Hoehn &amp; Yahr scale; subjects with characteristics that make transcranial direct current stimulation risky (neural implants, history of seizures, pacemaker, epilepsy); history of orthopedic and/or vision problems that make it impossible to comply with experimental procedures; indicative of dementia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-2v2k9gg	Neurostimulation of the motor area and its effects on anxiety, depression and inflammation in patients with rheumatoid arthritis	Not yet recruiting	Intervention	2022-07-08	<NULL>	<NULL>	5475	Transcranial Direct Current Stimulation (tDCS) on the motor cortex: effect on anxiety and depression symptoms and the interplay with the inflammatory profile of pacients suffering from chronic pain since diagnosed with rheumatoid arthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-15	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-2v2k9gg	<NULL>	Patients with chronic pain manifested for a minimum period of 12 weeks; in clinical treatment with synthetic DMARDs; who present pain in intensity greater or equal 7 by the visual analogical pain scale (EVA-Dor); Who present anxiety symptoms according to the Beck scale (psychological assessment instrument, BAI, Beck Anxiety Inventory); who present symptoms of depression according to the Beck psychological assessment instrument, BDI, Beck Depression Inventory	Patients who have other autoimmune diseases not related to AR; Who are being treated with biological DMARDs; pregnant women; who have a clinical diagnosis of major depressive disorder (greater than 30 in the evaluation score according to Beck Depression Inventory, BDI); with clinical diagnosis of generalized anxiety disorder (GAD), (greater than 31 in the evaluation score according to Beck Anxiety Inventory, BAI); patients with a history of skin diseases; who use high doses of opioids; with a history of illicit drug use/abuse; with metal implants in the cranial or facial region; that use pacemakers; with a history of seizures or epilepsy; with neurological, cognitive and motor deficits; patients who underwent craniotomy; patients with cancer diagnosis; decompensated disease (ischemic heart disease, kidney and/or liver diseases)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-4jq79xt	The treatment of a malocclusion related to lack of dental contact between the upper and lower teeth with a fixed appliance: a randomized clinical trial	Not yet recruiting	Intervention	2022-07-10	<NULL>	<NULL>	5476	Anterior Open Bite Treatment with Fixed Tongue Educator: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Federal do Pará	Centro Universitário do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4jq79xt	<NULL>	patients in mixed dentition; anterior open bite greater than or equal to 1 mm	Patients with cognitive difficulties; cleft lip and palate; syndromes and; or anomalies and dental agenesis will be previously excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-37xt8f6	Effect of co-contraction training on muscle mass, torque and functional capacities in older people	Not yet recruiting	Intervention	2022-07-13	<NULL>	<NULL>	5483	Effect of a coactivation training program, on functional capacity and gait biomechanical parameters, in older people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Marina Mello Villalba	Universidade de São Paulo - Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-37xt8f6	<NULL>	Healthy older; active or non active; aged between 60 to 80 years; available to participate in this research for eight weeks; non participant in any other physical exercise program during this period; all participants must sign an informed consent form.	Walking with an assistive device (cane, crutches, walker); presence of neurological disease; orthopedic impairment in the last 6 months in lower limbs (sprains, ligament ruptures, muscle injuries, fractures and surgeries); backache; vestibular impairment (presence of vertigo or labyrinthitis); non-corrective visual impairment by lenses; low score on the cognitive test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-10m474jv	Effect of photobiomodulation application on neck muscle pain	Not yet recruiting	Intervention	2022-07-18	<NULL>	<NULL>	5492	Effect of photobiomodulation on trapezius myofascial pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-15	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-10m474jv	<NULL>	Men or women aged 18 or over; diagnosis of trigger point in the upper trapezius muscle by the diagnostic criteria according to the consensus described in the study by Fernandez-De-Las-Penas and Dommerholt (2018), in which three criteria are established: two manual findings (a tense band and a hypersensitive point) and a symptom (referred pain, with characteristic depth and irradiation), requiring the presence of one of the manual findings and referred pain for the diagnosis to be positive.	neck or shoulder trauma; diseases that contraindicate the use of laser; surgery history; refusal to perform the assessment and intervention after randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-835hmdg	Comparison of intervention with conventional exercises and graded exposure for the treatment of shoulder pain	Not yet recruiting	Intervention	2022-07-19	<NULL>	<NULL>	5494	Graded exposure-based approach compared with a strengthening exercises and manual therapy in patients with chronic shoulder pain: a randomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-835hmdg	<NULL>	Individuals with shoulder pain in the proximal anterolateral aspect of the shoulder; aggravated by movement; who present symptoms lasting at least three months and who present a minimum score of 50 points on the disability scale (Shoulder Pain and Disability Index)	Individuals with a history of trauma or surgery in the shoulder; total rupture of the rotator cuff and biceps tendon; practitioners of sports-level physical activity involving the upper limbs; individuals with a history of cancer; neurological; cardiac and systemic disorders (rheumatoid arthritis or fibromyalgia) in order not to compromise the study objectives; reproduction of shoulder pain with radiating pain; numbness or tingling in the upper limb as an indication of primary involvement in the cervical or thoracic region; presence of wrist dysfunctions (eg. carpal tunnel syndrome); have undergone physical therapy treatment for the shoulder or any other musculoskeletal condition in the last six months; individuals who have contraindications for physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-366n64w	Stimulating Disfunctional Bowel before Ileostomy Closure	Not yet recruiting	Intervention	2022-07-19	<NULL>	<NULL>	5496	Stimulating Excluded Loop before Ileostomy Closure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-366n64w	<NULL>	Adult patients (older than 18 years); with rectal cancer in clinical stages cT3/4Nx or cTxN+; that maybe treated with neoadjuvant chemoradiotherapy; anda submitted to laparoscopic or robotic total mesorectal excision, and submitted to loop protection ileostomy; And also patients who are not undergoing systemic chemotherapy	Patients who refuse to participate in the study; Patients with a history or suspicion of inflammatory bowel disease; Pregnant patients; Patients who have any contraindication for general anesthesia or surgical intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-5hq9y3k	Development of a nurses&apos; training to improve the perception over patients becoming severely ill	Not yet recruiting	Intervention	2022-07-20	<NULL>	<NULL>	5499	Nurses&apos; training for early clinical deterioration assessment and management	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Estadual de Campinas (Unicamp)	University of Rhode Island	https://ensaiosclinicos.gov.br/rg/RBR-5hq9y3k	<NULL>	All the floor nurses, both genders, allocated to an adult inpatient unit at a University Hospital in the state of São Paulo will be considered eligible	All nurses who are inactive, on leave, and on vacation during the data collection period will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-108bctm7	Intra-hospital rehabilitation versus conventional physical therapy in post-intensive care syndrome: a randomized controlled trial	Not yet recruiting	Intervention	2022-07-21	<NULL>	<NULL>	5504	Integrated actions to prevent post-intensive care syndrome and better use of health resources.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-22	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-108bctm7	<NULL>	The following will be eligible for the study: patients over 18 years of age who were discharged from the ICU and who has remained in the ICU for at least 5 days and/or who underwent mechanical ventilation for 72 hours or more; patients diagnosed with ICU-acquired muscle weakness with a Medical Research Council (MRC) score of less than 48/60 in 12 muscle groups or an average MRC of minus 4 per muscle group; be able to understand the proposed protocol; have access to a telephone. Will be included in the study: all patients considered eligible and who sign the free and informed consent form. Consent may be provided and the consent form signed by a family member or caregiver, by mutual agreement, in the impossibility of signature by the participant himself.	Will not be eligible: patients with a survival expectancy of less than six months or who are in palliative care; patients with neurological injury that determines permanent impairment of consciousness, neurodegenerative diseases such as Parkinson&apos;s, Alzheimer&apos;s or previous dementia or that the reason for admission to the ICU is spinal cord injury (SCI), cerebrovascular accident (CVA) and/or neuromuscular disease, such as Guillian -Barré, Myastenya gravis, multiple and/or amyotrophic lateral sclerosis; present unstable fractures in the upper limbs (MMSS), lower limbs (LL) and spine; presence of absolute or relative contraindications for exercise according to the recommendations of the American College of Sports Medicine. Will be excluded: those who withdraw consent after signing the TCLE; patients who for some reason return to the ICU; participants who are unable to perform the protocol and proposed assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-64n2g5h	Pilates methods can cause perineal effects and Exercises in the treatment of perineal dysfunctions in postpartum women: a randomized clinical trial	Not yet recruiting	Intervention	2022-07-22	<NULL>	<NULL>	5505	Effects of the pilates method with floor activation pelvic and Perineal exercises in the treatment of Dysfunctions of the pelvic floor in postpartum women: clinical test randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-64n2g5h	<NULL>	Will be included in the present study; women who have given birth within one year; who are in the age group between 18 and 50 years; who have gynecological complaints arising from pelvic floor dysfunctions; who answer yes to at least two of the nine questions asked in the questionnaire during the assessment; and who reside in the city of Quixeré CE	They will be excluded from the present study; women who do not enjoy full mental health to answer the form and/or questionnaire; who have performed any surgical procedure involving the pelvic floor area as well as total or partial hysterectomy and/or perineal surgery; who present pathologies that interfere with the muscle health of the pelvic floor; that sketch pelvic muscle strength equal to or less than grade 1 in the assessment; women who have passed or are going through climacteric; and those who are already or who have been in any type of treatment related to floor dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-106x5n9j	Innovative technologies applied to tuberculosis and HIV surveillance	Not yet recruiting	Intervention	2022-07-26	<NULL>	<NULL>	5511	Innovative technologies applied to tuberculosis and HIV surveillance	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-106x5n9j	<NULL>	Patient over 18 years old with indication for Tuberculosis treatment; patient who has access to a smartphone; patient who agrees to participate in the research	Patients without indication for Tuberculosis treatment; patients deprived of liberty; patients without access to a smartphone; homeless or hospitalized patients; patients with limitations in understanding the application&apos;s commands and their functions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-55n74zm	Carotid-Body modulation through Meditation in Hypertensive subjects	Not yet recruiting	Intervention	2022-07-28	<NULL>	<NULL>	5514	Carotid-Body modulation through Meditation in stage-I Hypertensive subjects: study protocol of a  randomized and controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal de Mato Grosso do Sul	Hospital Universitário Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-55n74zm	<NULL>	Subjects of both sexes; aged between 30 and 70 years; patients with arterial hypertension or using at least one antihypertensive medication; stage I systemic arterial hypertension with a minimum diagnosis of 1 year; use of unchanged antihypertensive medication for at least 2 months; did not participate in regular exercise programs 3 or more times a week in the last 3 months prior to the study; are able to read; speak and understand Portuguese	Subjects who do not adhere to the experimental protocol; who have a diagnosis of heart failure greater than or equal to New York Heart Association I; chronic obstructive pulmonary disease; cognitive impairment that makes it impossible to understand the protocols; or psychiatric disease; previous stroke; neuromuscular disease; asthma; uncontrolled diabetes; vascular disease peripheral; obesity grade III; renal failure of stage greater than 2; sleep apnea; malnutrition; or other diseases that interfere with the performance of the protocol; and lack of more than two sessions of supervised meditation; secondary hypertension; individuals with contraindications to performing a symptom-limited maximal exercise test; and individuals who regularly practice meditation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-5qyszr9	Assessment of skin irritability	Not yet recruiting	Intervention	2022-07-28	<NULL>	<NULL>	5516	Assessment of primary dermal irritability, accumulated dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5qyszr9	<NULL>	Participants of both sexes; age between 18 and 70 years; phototypes: I, II, III and IV (according to the Fitzpatrick adapted scale – Annex 1); intact test region skin; agreement to comply with the trial procedures and to attend the clinic on the days and times determined for the medical evaluations and for the application and reading of the dressings, understanding, consent and signing the Free and Informed Consent Form (FICT)	Participants who have been diagnosed with COVID-19 in the last 4 weeks or who have symptoms such as fever, dry cough, tiredness, body aches or other discomforts; pregnancy or risk of pregnancy and/or lactation (when female); use of anti-inflammatory drugs for 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases, decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; predicted intense exposure to sunlight or tanning sessions during the study period; forecast of bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month before the start of the study; cosmetic and/or dermatological treatment on the body within 3 weeks prior to selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization and irritation to topical product; active skin pathologies (local and/or disseminated) that could interfere with the study results; use of new drugs and/or cosmetics during the study; skin reactivity; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in study products (test or comparative products); history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study, or other conditions deemed by the researcher to be reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-897tzz6	Evaluation of the safety and efficacy of using the mint-flavored denture fixative cream product through Acceptability Assessment in the oral cavity	Not yet recruiting	Observational	2022-07-29	<NULL>	<NULL>	5517	Clinical study to evaluate the safety of the investigational product mint-flavored denture fixative cream through the Assessment of Acceptability in the oral mucosa and Perceived Efficacy under normal conditions of use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-05	Kosmoscience Ciência e Tecnologia Cosmética Limitada	Cimed Industria Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-897tzz6	<NULL>	Age range between 18 and 60 years. Female and male. Phototype (Fitzpatrick): I to VI. Being a user of removable dental prostheses (dentures). Be a user of products of the same category. Agree on procedures and requirements during study use: study time (after 21 days) laboratory to perform investigational product home study procedures, change the product study diary, do not change the study product study diary. Agree to perform facial aesthetic dermatological treatments until the end of the study (21 days), such as: peelings, laser, fillers, use of any unusual suitable products	Pregnant or lactating women. Participant who belongs to the risk group for COVID-19, that is, with cardiovascular, renal and chronic respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group. Presence of dermatoses, active skin lesions (local and/or disseminated) or irritation in the mouth region (internal or external). Expected vaccination during the study or up to 3 weeks before the study. History of oral pathologies. Use of non-steroidal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study. Be participating in another study in the same application region. History of non-adherence or unwillingness to adhere to the study protocol. Being undergoing dental treatment. Not taking vitamin A or derivatives. Any condition that, in the opinion of the researcher, could compromise the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7cr9yvf	Development of CAR-T cells to treat malignant B neoplasms	Not yet recruiting	Intervention	2022-07-30	<NULL>	<NULL>	5519	Development of car-t cell for B malignacies treatment - Phase I clinical trial with autologous T cell genetically modified to express chimeric antigen receptor (car) to treat refractory or relapsed patients with B neoplasm CD19+	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-7cr9yvf	<NULL>	Provision of the dated and signed free and informed consent form (IC); express willingness to comply with all study procedures and availability during the study; men or women; age 02 and 70 years; Good general health, proven by medical history; diagnosis of refractory or recurrent ALL or LLC and non-Hodgkin lymphoma; Ability to administer oral medications; for women with reproductive potential: use of highly effective contraceptive for at least 1 month before screening and agree to use a contraceptive method during participation in the study and for an additional 4 months after the completion of the administration of CAR T cells; for men with reproductive potential: use of condoms or other methods to ensure effective contraception with the partner; Agreement to adhere to Lifestyle Recommendations: Women of childbearing potential, defined as all women physiologically capable of becoming pregnant, must use highly effective contraceptive methods at least 4 months after the infusion of CAR-T; Sexually active men must use a condom during sexual intercourse from the moment the project is signed for at least 4 months after the infusion of CAR-T. A condom is required for all sexually active male participants to prevent them from having a child and to prevent delivery of the study treatment via the seminal fluid to their partner. In addition, participants must not donate sperm. The subjects should attend the consultations, do the tests according to the protocol, use antibiotics and other medications as indicated. Individuals must have ALL, LLC or relapsed or refractory lymphoma treated with at least two lines of treatment. The disease must have progressed or show partial remission or the complete response must not have been achieved with the last regimen; individuals with Philadelphia Chromosome positive acute lymphoblastic leukemia (ALL + Ph) are eligible if they have progressed, have a stable or recurrent disease after two lines of treatment, including tyrosine kinase inhibitors (TKIs); Individuals with LNHDGCB (large B-cell non-Hodgkin&apos;s lymphoma) must have progressed, presented with stable disease or recurrence after initial treatment regimens that include an anthracycline and an anti-CD20 monoclonal antibody; Individuals with transformed LF (follicular lymphoma), LZM (mantle zone lymphoma) or LLC / ALL must have progressed, presented with stable disease or recurrence with transformed disease after initial treatment for LNHDCGB; Individuals who had a recurrence ≥12 months after treatment must have progressed after autologous transplantation or be ineligible for autologous transplantation; The patient&apos;s disease must be positive for CD19 by immunohistochemistry or flow cytometry analysis in the last available analysis; 2 to 70 years of age; General status: Adult individuals: ECOG less than or equal 2 for individuals over 16 years old; Lansky greater than or equal to 50% for individuals under 16 years old; Normal Functioning of Organs and Marrow (supportive treatment is allowed according to institutional rules, that is, filgrastim, transfusion): Total bilirubin ≤ 2; AST (TGO) ≤ 5 times the normal limit; ALT (TGP) ≤ 5 times the normal limit; Serum Creatinine ≤ 1.5; Pulse oximetry&gt; 91% in room air; Absence of dyspnea or mild dyspnoea (≤ Grade 1); Forced expiratory volume in 1 s (FEV1) ≥50% or carbon monoxide diffusion test (DLCO) ≥50% of the predicted level; Left ventricular ejection fraction ≥45% confirmed by echocardiogram; individuals must have the following parameters of hematological function: Neutrophil&gt; 1000 / ul; Absolute Lymphocyte Count&gt; 100 / ul; Platelets&gt; 50,000 / ul; Patient should not be excluded if the above parameters are changed due to infiltration of spinal disease; Elimination of prior treatment: At least 2 weeks or 5 half-lives, whichever is longer, must have elapsed since any previous systemic therapy at the time that leukapheresis is planned for the individual, except systemic inhibitory checkpoint therapy / immunostimulant, which requires 5 half-lives. Patient with previous treatment with blinatumumab, at least 4 months after the last application; Individuals must be able to understand in order to be willing to sign an informed consent form.	Autologous transplantation within 6 weeks of the planned infusion of CAR T cells; history of allogeneic stem cell transplantation of hematopoietic stem cells (HSCT) 4 months before the infusion; receiving treatment with CAR T cells outside this protocol; compromise of the active central or meningeal system by tumor. Individuals with untreated brain metastases / CNS disease will be excluded from this clinical study because of their unfavorable prognosis and because they often develop progressive neurological dysfunction that would confuse the assessment of neurological and other adverse events. Patients with a history of CNS or meningeal involvement should be in documented remission by assessing cerebrospinal fluid and contrast-enhanced MRI for at least 90 days before registration; history of active malignancy, other than non-melanoma skin cancer, carcinoma in situ (eg, cervical, bladder, breast); HIV infection; HTLV; individuals with uncontrolled intercurrent disease, among others, existing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, lung abnormalities or psychiatric diseases / social situations that would limit compliance with the requirements of the study; pregnant or lactating women are excluded from this study, as treatment with CAR T cells may be associated with the potential for teratogenic or abortion effects. Fertile women must have a negative serum pregnancy test result. As there is an unknown but possible risk of adverse events in infants secondary to the mother&apos;s treatment with CAR T cells, breastfeeding should be discontinued. These possible risks can also be applied to other agents used in this study. Fertile individuals must be willing to use contraceptives from admission to this study and for 4 (four) months after receiving the preparatory regime; evidence of myelodysplasia or cytogenetic abnormality indicative of myelodysplasia in any bone marrow biopsy before the start of treatment; serological status reflecting active hepatitis B or C infection. Patients who test positive for hepatitis B core antibody, hepatitis B surface antigen (HBsAg), or hepatitis C antibody must have a negative polymerase chain reaction (PCR) result prior to admission. (patients with a positive PCR result will be excluded); serious and / or potentially fatal medical conditions; patients with a clinical history of pathology in the relevant central nervous system such as epilepsy, convulsive diseases, paresis, aphasia, severe brain injury, dementia and Parkinson&apos;s disease; history of autoimmune disease (such as rheumatoid arthritis, systemic lupus erythematosus) in need of immunosuppressive medication in the last 12 months; history of severe hypersensitivity to one of the agents used in the study; creatinine level below 30 ml / min	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-8mdbmcp	The effects of Nordic curl performed once a week on injury protection and performance improvement in athletes: a clinical trial	Not yet recruiting	Intervention	2021-03-17	<NULL>	<NULL>	5520	Effects of a low volume protocol of Nordic hamstring exercise on risk factors for musculoskeletal injuries and athlete performance: a  clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-09-19	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8mdbmcp	<NULL>	Intermittent sports athletes (e.g., futsal, soccer and rugby); male; aged 18 to 40 years; and who practice the sport with competitive objectives.	Athletes will be excluded if they have any health condition that prevents them from performing the sports practice, the Nordic hamstring exercise, and the physical tests during the research; enter or leave the club after the beginning of the games and training; are injured or have injured their hamstrings or anterior cruciate ligaments of the knees in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-57b63d	Evaluation of the irritation potential of HG22	Not yet recruiting	Intervention	2020-05-26	<NULL>	<NULL>	5540	Assessment of primary and cumulative irritation potential, sensitization potential of the skin and the potential for phototoxicity and photoallergy of the skin supervised by Dermatologist for HG22 Vaginal Moisture Restorative Product	<NULL>	1, single-arm-study, single-blind	1	<NULL>	<NULL>	<NULL>	2022-08-30	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-57b63d	<NULL>	Participants of both sexes; Age between 18 to 65 years; Phototypes: I, II, III and IV; Skin of the whole test region; Agreement to obey the trial procedures and attend the clinic on the days and times determined for medical evaluations and for application and reading of the dressings; Understand, consent and sign the Free and Informed Consent Form (ICF).	Pregnancy or risk of pregnancy and / or lactation; (when women); Background atopic or allergic to health products; Use of anti-inflammatory drugs 30 days and / or immunosuppressive for up to three months before selection; Diseases that cause suppression of immunity, such as diabetes and HIV; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the evaluation; Prediction of intense exposure to sunlight or tanning sessions during the study period; Prediction of sea baths, pool or sauna during the study; Water sports practice during the study; 10) Dermographism (property that has the skin of certain individuals to swell and redden in the place where it is streaked by something relatively sharp); Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the beginning of the study; Aesthetic and / or dermatological treatment on the body within 03 weeks before selection; Vaccination scheduled during the study period or up to 03 weeks before selection; History of sensitization and irritation to a topical product; Active skin pathologies (local and / or disseminated) that may interfere with the results of the study; Use of new drugs, health products that are not part of the participant&apos;s routine during the study; Skin reactivity; Previous participation in studies with the same product; Known history or suspected intolerance to any ingredient in the study products (test or comparative products); History of lack of adherence or unwillingness to adhere to the study protocol; Other conditions considered by the evaluating physician as reasonable for the disqualification from participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-8nkqvw4	Evaluation of irritability and sensitization of a skin cream, through the Contact Test	Not yet recruiting	Intervention	2022-08-10	<NULL>	<NULL>	5541	Evaluation of primary, accumulated dermal irritability and sensitization of a cream, through the Patch Test_TCI01.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-26	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	TCI Biotecnologia Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8nkqvw4	<NULL>	Male and female; Age: 18 to 65 years; Phototype: I to IV; Whole skin of the area	Participants who refuse to participate in the study in question; Revision marks and experimental area that interfere in the evaluation of reactions of reactions; Active dermatoses (local and disseminated) that may interfere with the study results; Pregnant or lactating women; History of drugs for allergic reactions, purchases or products of sensations of intense and topical use: Volunteers with a history of allergies to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergies and products in the category tested; Recent gynecological surgeries; discharges; History of pathologies aggravated or triggered by ultraviolet radiation; Immunodeficiency carriers; Kidney, heart or liver transplants; Forecast of intense sun exposure or tanning session during the period conducting the study; Forecast to take a bath in the sea, swimming pool or sauna during the study; Participants who play sports; Use of the following systemic topical drugs: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Treatment with acidic vitamin A and/or its oral or topical delivery up to 1 month before the start of the study; Forecast before carrying out study 03; Any condition not mentioned above that may, in the opinion of the investigator, carry out an evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-9586tdy	Efficacy of Ozone Treatment in Patients with Circulatory Disease (in the veins) and Leg Wounds	Not yet recruiting	Intervention	2022-08-10	<NULL>	<NULL>	5542	Evaluation of the Efficacy of Ozone Therapy Applied to the Treatment of Venous Ulcers: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9586tdy	<NULL>	Patients over 18 years of age; Both sexes; Confirmed medical diagnosis of venous insufficiency recorded in the patient&apos;s medical record and confirmed by USG doppler of the lower limbs; Presence of pedal and tibial pulses after palpation in the lower limbs	Patients with infectious and contagious disease; Chronic use of corticosteroids; Bedridden or wheelchair; Diabetics; Pregnant women; Patients who show signs of allergy to any of the components of the Unna Boot; Infection in the ulcer bed; Low adherence: Irregularities in the frequency of visits to consultations (Missing 3 times without justification) or discontinuity in the use of the products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7tvbt4v	Comparison of feeding transition time in premature newborns exposed to Speech Therapy.	Not yet recruiting	Intervention	2022-08-11	<NULL>	<NULL>	5544	Comparative analysis of the food transition process of premature newborns after the application of Speech Therapy Intervention Programs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-23	Irmandade da Santa Casa de Misericórdia de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7tvbt4v	<NULL>	Newborns conceived, with a gestational age of 37 weeks according to the corrected gestational age; preterm newborn who have not yet started offering oral feeding	Presence of genetic syndromes congenital malformations of the head and neck or central nervous system; neurological disorders; clinical instability at the beginning and throughout the study based on the analysis of the medical team on respiratory and cardiac instability of the newborn; levels saturation below 90%; respiratory rate above 60 or any other intercurrences that make speech-language intervention impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-10v4dxgm	Transcranial Direct Current Stimulation and Physical Exercise on interlimb coordination, cortical activity and gait parameters in individuals with Parkinson&apos;s disease	Not yet recruiting	Intervention	2022-08-15	<NULL>	<NULL>	5551	Effects of Transcranial Direct Current Stimulation combined with Physical Exercise on individuals with Parkinsons disease locomtion and cortical activity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-20	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-10v4dxgm	<NULL>	Individuals aged 60 or over will be included; both genders; diagnosed with idiopathic Parkinsons disease, based on criteria determined by the London Brain Bank	Participants with a stage greater than 3 on the Hoehn &amp; Yahr scale; insanity; history of orthopedic and vision problems that make it impossible to comply with the experimental protocol; patients at risk of receivingtranscranial direct current stimulation (neural implants, pacemakers, history of seizures and epilepsy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-4b5kzhd	Antibody persistence at 6 months or more in individuals primed with 2 doses of an inactivated vaccine who received a heterologous or homologous third dose – extension of study RHH_001 and safety and immunogenicity of a 4th dose with recombinant covid-19 vaccine (AstraZeneca/Fiocruz) or mRNA covid-19 vaccine (Comirnaty, Pfizer/ Wyeth)	Not yet recruiting	Intervention	2022-08-17	<NULL>	<NULL>	5557	Persistence of binding and neutralizing antibodies against SARS-CoV2 strains at 6 months or more after a third dose with recombinant covid-19 vaccine (AstraZeneca/Fiocruz), mRNA covid-19 vaccine (Comirnaty, Pfizer/ Wyeth), recombinant covid-19 vaccine (Janssen) or adsorbed inactivated Covid-19 vaccine Coronavac (Sinovac/ Butantan) in subjects primed with two Sinovac/Butantan doses – extension of study RHH_001 and assessment of safety and immunogenicity of 4th dose with recombinant covid-19 vaccine (AstraZen	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-10-15	Instituto D&apos;Or de Pesquisa e Ensino	Universidade de Oxford	https://ensaiosclinicos.gov.br/rg/RBR-4b5kzhd	<NULL>	Participants in study RHH 001 per protocol population who were fully evaluable. Those participants included in previous neutralization assay subsets will be targeted for enrolment first if operationally feasible; Subjects willing and able to provide informed consent prior to any study procedure; Participants willing and able to comply with the study procedure; Subjects who had received heterologous or homologous third vaccine dose 6 months or more prior to this study. For part 2 in addition: nformed consent to receive 4 th vaccine dose, AstraZeneca/Fiocruz or Pfizer/Wyeth; No contraindication against AstraZeneca/ Fiocruz or Pfizer/ Wyeth SARSC0V2 vaccine; For females of childbearing potential: willingness to practice continuous effective contraception during the study and a negative pregnancy test on the days on day of vaccination.	Any additional SARSCoV2 vaccine after the 3rd dose in study RHH 001. For part 2 in addition: Participants with a history of serious vaccine-related adverse reaction or serious allergic reaction (e.g., anaphylaxis) to any study vaccine component, as described in the last summary of product characteristics for AstraZeneca/Fiocruz or Pfizer/Wyeth; Participants with a known bleeding disorder that, in the investigator’s opinion, would contraindicate intramuscular injection; Participants with any progressive or serious neurological disorder, seizure disorder or history of Guillian-Barré syndrome; Participants given treatment with immunosuppressant therapy within the last 90 days, including cytotoxic agents or systemic corticosteroids or planned receipt during the study period. If a short-term cycle of immunosuppressant systemic corticosteroid dose has been used to treat acute disease, the participant should not be enrolled in the study until corticosteroid therapy has been discontinued for at least 15 days prior to the first study vaccination. In case the participant has been on an immunosuppressant dose of a depot, intramuscular or intra-articular corticosteroid, 60 days should be waited for their enrolment in the study. Inhaled/nebulized, intra-articular, intrabursal or topical (skin or eyes) corticosteroids are allowed; Participants with autoimmune diseases, other than: Hashimoto thyroiditis, vitiligo, psoriasis, discoid lupus and the like; HIV positive participants and/or in treatment for HIV; Participants given any other investigational product within the 30 days prior to administration of 4th dose or who intend to take part in another clinical trial at any time during this study conduction; Participants given any other licensed vaccine within 14 days prior to enrolment in this study or who plan to receive any vaccine up to 28 days after vaccination; Participants given treatment with Rituximab or any other anti CD20 monoclonal antibody within 9 months prior to administration of 4 th dose or planned during the study period; Administration of intravenous immunoglobulins and/or any blood products within 3 months prior to enrolment or planned dosing during the study period; Participants with any condition that, in the investigator’s opinion, could interfere with the status primary objectives or represent an additional risk for the participant. Temporary exclusion criteria for both Part 1 and Part 2: Participants with a recent history of COVID19 (minor 4 weeks prior to visit 1) will be delayed until 4 weeks after diagnosis; Participants with fever major 37.5 °C (axillary) or any acute disease at baseline (Day 1) or within the 3 days prior to randomization. Febrile participants with mild diseases may be enrolled at the investigator’s discretion once fever has resolved.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-2tqjyp9	Neuromuscular electrical stimulation protocol in intensive care unit-acquired weakness (ICUAW) patients: a clinical, prospective and randomized study	Not yet recruiting	Intervention	2021-07-06	<NULL>	<NULL>	5564	Neuromuscular electrical stimulation protocol in intensive care unit-acquired weakness (ICUAW) patients: a clinical, prospective and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-02	Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2tqjyp9	<NULL>	Individuals aged between 18 and 65 years; using invasive mechanical ventilation for more than 24 hours.	neuromuscular desease; neurodegenerative desease; autoimmune desease; aneurysm, traumatic brain injury; severe spinal cord injury; stroke	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-103c2tr6	Effect of the application of Osteopathic Techniques on pulmonary function and quality of life of individuals with Chronic Obstructive Respiratory Diseases	Not yet recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5568	Effect of Manual Osteopathic Techniques (BMT) on lung function and quality of life in patients with Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2022-09-01	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-103c2tr6	<NULL>	Adult men and women; age group between 35 and 70 years; patients with Chronic Obstructive Pulmonary Disease; stable clinical picture; no exacerbation of the condition in the last three months; agreement and signature of the Free and Informed Consent Form	Pregnant women; individuals with advanced osteoporosis; fractures in the consolidation phase; cancer; thoracic surgeries; decompensated heart disease; systemic arterial hypertension; physical or cognitive factor that limits or prevents the understanding and execution of the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-723bk5p	The effect of Alogliptin in the prevention of Type 1 Diabetes Mellitus	Not yet recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5570	Evaluation of the effect of Alogliptin in the prevention of type 1 Diabetes Mellitus	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-09-30	Universidade Federal do Ceará	Universidade de São Paulo - Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-723bk5p	<NULL>	Patients of both sexes aged between 18 and 35 years; Confirmed diagnosis of stage 2 autoimmune diabetes mellitus through the presence of 1 or more positive pancreatic islet autoantibodies anti-insulin antibodies, anti-GAD, IA-2, anti-ZnT8A associated with 2 blood glucose values fasting glucose between 100-124 mg/dL or 2 glycated hemoglobin values between 5.7%-6.4% or a fasting glucose between 100-124 mg/dL + 1 glycated hemoglobin value between 5.7%-6.4%	Pregnant women, breast-feeding women or those who wish to conceive in the last 3 months; Patients with a clinical-laboratory diagnosis of diabetes; Patients on insulin therapy or any other hypoglycemic therapy at the time of inclusion; chronic kidney failure carriers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-9b3mcsx	Nursing care based on Theory of Self-Care for people with chronic Chagas Disease	Not yet recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5571	Nursing care based on Orem&apos;s Theory of Self-Care for patients with chronic Chagas Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-29	Faculdade de Ciências da Saúde da Universidade do Estado do Rio Grande do Norte	Faculdade de Ciências da Saúde da Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9b3mcsx	<NULL>	People with Chagas Disease in the chronic form who are registered and treated at the Chagas Disease Outpatient Clinic; Be over 18 years old	For some ethical or legal-legal reason they are unable to respond; Those who do not have the physical conditions to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-7bvmccs	Is self-selected exercise (where people can choose the load) able to provide health benefits?	Not yet recruiting	Intervention	2022-08-25	<NULL>	<NULL>	5581	Effect of imposed and self-selected exercise on perceptual and affective responses, muscle function and quality and functionality in strength training in elderly women and men	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7bvmccs	<NULL>	Be over 60 years of age; Have conditions that allow the regular practice of exercise; Submit negative responses to all items on the Revised Physical Activity Readiness Questionnaire (rPAR-Q); Not having participated in strength training programs in the last 6 months.	Be under 60 years of age; Not having conditions that allow the regular practice of exercise; Provide positive responses to all items of the Revised Physical Activity Readiness Questionnaire (rPAR-Q); Be physically active.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-3rgpwg	Dermatological Evaluation of HB22	Not yet recruiting	Intervention	2020-05-25	<NULL>	<NULL>	5584	Assessment of primary and cumulative irritation potential, sensitization potential of the skin and the potential for phototoxicity and photoallergy of the skin supervised by dermatologist for vaginal moisture restorative product HB22	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-30	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-3rgpwg	<NULL>	Male and female participants; Age group between 18 and 65 years; Be in agreement not to change your habits of using health products, including hygiene; Skin intact in the test region; Agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for reading the dressings; Understanding, agreement and signing the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and / or lactation; (when women); Atopic or allergic background to health products; Use of anti-inflammatory drugs 30 days and / or immunosuppressive for up to three months before selection; Diseases that cause suppression of immunity, such as Diabetes, HUman Immunodeficience Vírus, etc; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the evaluation; Prediction of intense exposure to sunlight or tanning sessions during the study period; Prediction of sea baths, swimming pool or sauna during the study; Water sports during the study; Dermographism (property that has the skin of certain individuals to swell and redden in the place where it is streaked by something relatively sharp); Use of oral or topical treatment with vitamin A acid and / or its derivatives up to 1 month before the beginning of the study; Aesthetic and / or dermatological treatment on the body within 03 weeks before selection; Vaccination scheduled during the study period or up to 03 weeks before selection; History of sensitization and irritation to a topical product; Active skin pathologies (local and / or disseminated) that may interfere with the results of the study; Use of new drugs and / or health products during the study; Skin reactivity; Previous participation in studies with the same product; Known history or suspected intolerance to any ingredient in the study products (test or comparative products); History of lack of adherence or unwillingness to adhere to the study protocol; Other conditions considered by the researcher to be reasonable for disqualifying participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-99m424c	Efficacy of acupuncture on quality of life, functional performance, shortness of breath, and lung function in patients with Pulmonary emphysema: randomized clinical trial	Not yet recruiting	Intervention	2022-09-01	<NULL>	<NULL>	5587	Efficacy of acupuncture on quality of life, functional performance, dyspnea and pulmonary function in patients with Chronic obstructive pulmonary disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-99m424c	<NULL>	Clinical diagnosis of COPD according to GOLD; ability to offer written authorization or indicate a person to read the Free and Informed Consent Form (ICF), with the agreement of the research participant; there will be no age limit, however individuals who are over 65 years old must have preserved cognitive function according to the Mini-Cog (individuals under 65 years old will not do the Mini-Cog); clinical stability in the month prior to the beginning of the protocol.	Patient with a previous medical diagnosis of a disease that affects the cognitive and does not allow the understanding of the questionnaires; individuals unable to perform any of the assessments; individuals who had exacerbations of the condition in the month prior to the beginning of the protocol; prior acupuncture therapy; being in a rehabilitation group or having been in the last 3 months; individuals who present an exacerbation of the clinical condition during the collection period will be excluded;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-10hdj2bg	Evaluation of the pharmacist&apos;s performance in the care of hospital discharge patients in the cardiology unit of a teaching hospital in Espírito Santo	Not yet recruiting	Intervention	2022-09-02	<NULL>	<NULL>	5591	Evaluation of Pharmaceutical Services for Clinical Support to Hospital Discharge in the cardiology unit of a teaching hospital in Espírito Santo	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-30	Leonardo Coutinho Ribeiro	Empresa Brasileira de Serviços Hospitalares (EBSERH)	https://ensaiosclinicos.gov.br/rg/RBR-10hdj2bg	<NULL>	Patients over 18 years of age; both sexes, admitted to the Cardiology Ward, who entered the institution under study on an emergency basis, agreed to sign the free and informed consent form (FICT) and voice recording term	Electively admitted patients; no contact phone; without autonomy to self-administer, without assistance from others, medication and who are not accompanied by a family member or caregiver who can provide necessary and reliable information about their treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-7y24t7t	Assessment of heart rate variability and body composition in the elderly undergoing Exercise and Gametherapy	Not yet recruiting	Intervention	2022-08-11	<NULL>	<NULL>	5593	Evaluation of autonomic cardiac modulation and body composition in elderly submitted to the Protocol of exercise and the Gametherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Sáskia Fürstenberg Thoma	Unifacisa- Centro Universitário	https://ensaiosclinicos.gov.br/rg/RBR-7y24t7t	<NULL>	Active elderly people who do physical activity according to the IPAQ (short form) will be included, a questionnaire that aims to carry out a global survey of the prevalence of physical activity in the world (MATSUDO et al, 2001) (ANNEX B). They must be elderly people over 60 years of age who live in the city of Campina Grande-PB and/or adjacent cities, due to the ease of accessibility to the services offered; that have means of transportation that allow their transport to the collection site, as this is an elderly sample group, those who are unable to move will be under the responsibility of the researcher to transport them; those elderly with chronic degenerative diseases may also be included, if they are under drug control.	Exclusion criteria will be those who present disabling pathologies for performing aerobic activities (cardiopathies and decompensated respiratory pathologies), they will be excluded because the protocol requires a satisfactory level of cardiorespiratory resistance to perform the activities proposed by the protocol; those elderly who have musculoskeletal disorders that prevent them from participating in the collection and/or who make use of gait devices since the exercises require large amplitude movements, those who are over 80 years old also do not participate, thinking they have a risk that overcome the benefit and elderly people who are performing other aerobic or anaerobic activities so as not to interfere with the evidence of the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-2br4cwp	Effect of two types of Shoulder Stretching on pain and mobility in Symptomatic Athletes	Not yet recruiting	Intervention	2022-09-08	<NULL>	<NULL>	5597	Effect of Posterior Shoulder Capsule Stretches in symptomatic overhead athletes with Internal Rotation Deficit: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-26	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2br4cwp	<NULL>	Overhead athletes aged between 18 and 40 years; competitive level; difference of at least 20 degrees of limitation in internal rotation compared to the non-dominant limb; pain in activities of daily living or sports at least 2 on the Visual Numerical Scale. Athletes with a previous history of glenohumeral instability; shoulder surgery; current symptoms related to the cervical spine; or structural injuries to the shoulder complex such as a fracture; labrum or tendon injuries will not be included	Athletes who injure their shoulder and/or elbow during the study; refusal to participate in study interventions and evaluations after randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-67wbv3r	Effects of physical exercise associated with laser therapy on functional capacity and muscle performance in individuals with persistent symptoms of Covid-19	Not yet recruiting	Intervention	2022-07-06	<NULL>	<NULL>	5598	Effects of physical exercise associated with photobiomodulation therapy on functional capacity and muscle performance in individuals with persistent symptoms of Covid-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Santa Catarina - Campus Araranguá	Laboratório de Avaliação e Reabilitação do Aparelho Locomotor-LARAL (UFSC/Campus Araranguá)	https://ensaiosclinicos.gov.br/rg/RBR-67wbv3r	<NULL>	Individuals aged between 18 and 70 years, of both genders with musculoskeletal pain, myalgia or arthralgia, persisting after four weeks of Covid-19 infection. Individuals with pain rating equal to or greater than 3 on the Visual Analogue Scale. Individuals classified as grade 1, 2 and 3 on the modified Medical Research Council scale	Individuals with pain rating lower than 3 on the Visual Analogue Scale. Individuals with grades 4 and 5 on the modified Medical Research Council scale. Individuals with chronic pain complaint in the treatment region, prior to Covid-19. Individuals with epilepsy, fibromyalgia, cardiac alterations and decompensated diabetes. Recent surgeries in regions related to the treatment site with less than 3 months; Laser photosensitivity; Continuous use of analgesics, muscle relaxants or anti-inflammatory drugs in the 48 hours prior to the intervention. pregnant women. Individuals with neurological and cognitive dysfunctions, such as dementia, intellectual disability, communicative deficit or any other condition that makes it impossible to understand the study procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3v9q7vx	Testing drugs that stop tooth decay	Not yet recruiting	Intervention	2022-09-13	<NULL>	<NULL>	5603	Comparative study between the effects of cariostatics in initial dental caries lesions: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-19	Gabriel Magalhães Cairo	Universidade Estadual do Sudoeste da Bahia - UESB	https://ensaiosclinicos.gov.br/rg/RBR-3v9q7vx	<NULL>	Children who have caries activity defined by the presence of at least one active initial lesion will be included (ICDAS-II Scores 1 and 2); no history of allergy to silver, colophonium, fluorine, chlorhexidine, xylitol or vehicles used in cariostatic formulations.	Children who used antibiotics in the last three months will be excluded; who use other systemic medications; who have dental elements with pulp involvement; carriers of syndromes or mental disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-9ktk6cv	Evaluation of the effectiveness of a educational game for the prevention of surgical site infection	Not yet recruiting	Intervention	2022-09-14	<NULL>	<NULL>	5607	Development and evaluation of the effectiveness of the Serious Game for the prevention of surgical site infection: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal do Triângulo Mineiro	Programa de Pós-Graduação strictu sensu em Atenção à Saúde	https://ensaiosclinicos.gov.br/rg/RBR-9ktk6cv	<NULL>	Healthy volunteers; Both sexes; students in the ninth and tenth period of the nursing course; age above 18 years	Volunteer with a history of dependence in the Fundamentals of Nursing discipline or in the discipline of Technical Nursing Bases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-7j4cc2k	BETERC: Brazilian epidemiological trial evaluation rotator cuff	Not yet recruiting	Observational	2022-09-19	<NULL>	<NULL>	5615	Brazilian cohort of patients undergoing rotator cuff repair	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7j4cc2k	<NULL>	Adult patients of both male and female; aged over 18 years; who have a rotator cuff injury with indication for surgical repair confirmed by the exam ultrasound or magnetic resonance imaging; with a record of consent to participate in the study by signing the free and informed consent form.	Patients who refuse to register their consent by signing the term of informed consent; with incomplete documentation; who do not have an magnetic resonance images (MRI) preoperative magnetic field capable of confirming their injuries and those who lose the postoperative follow-up. Those with a history of fracture in the shoulder girdle; previous shoulder surgeries; local neoplasia or undergoing surgical treatment for re-rupture of the rotator cuff will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-249zxxh	Development of an ointment for the treatment of cutaneous Leishmaniasis	Not yet recruiting	Intervention	2022-09-19	<NULL>	<NULL>	5616	"Development and evaluation of a topical formulation containing jucá product
(Libidibia ferrea) for the treatment of cutaneous Leishmaniasis"	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Amazonas - UFAM	INPA - Instituto Nacional de Pesquisas da Amazônia	https://ensaiosclinicos.gov.br/rg/RBR-249zxxh	<NULL>	Age between 18 and 70 years; both genders; Individuals considered healthy after initial clinical and laboratory evaluation; Agreement and voluntary signature of the free and informed consent form	Individuals who present alterations in the pre-treatment clinical and/or laboratory assessment; History of visceral leishmaniasis or American cutaneous leishmaniasis; Liver or kidney dysfunction, diabetes or heart disease; Allergy to the experimental treatment; Pregnant and lactating women; Alcoholics, smokers or those using medication; Patients with chronic diseases and/or infectious diseases such as tuberculosis, leprosy, human immunodeficiency virus, visceral leishmaniasis or American cutaneous leishmaniasis, among others; Patients with a medical history of visceral leishmaniasis or American cutaneous leishmaniasis; Inability or refusal to sign the informed consent form or inability to comply with the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-53gfpy9	Evaluation of Bone Loss around teeth in radiographs of children and adolescents treated at Piracicaba Dental School	Not yet recruiting	Observational	2022-09-21	<NULL>	<NULL>	5619	Evaluation of Radiographic Bone Loss in children and adolescents treated at Piracicaba Dental School. Retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-01	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-53gfpy9	<NULL>	Patients of both genders; aged between 1 and 15 years; patients that presented interproximal radiographs taken between 2011 and 2020; the most recent radiograph from each region will be included as a measurement reference for the analysis;	Interproximal radiographs that are not angled perpendicular to the tooth; are not of good quality; Individual sites in which the cementoenamel junction (CEJ) or alveolar bone crest (BC) are not visible; the presence of overlapping structures that make the evaluation unfeasible; deciduous molars that are exfoliating with extensive root resorption	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-4dk4rss	A study to evaluate innate and pro-inflammatory responses of an Ad26-based SARS-CoV-2 vaccine, an Ad26-based RSV vaccine, and an Ad26-based Ebola virus vaccine in adults aged 18 to 59 years	Not yet recruiting	Intervention	2022-09-21	<NULL>	<NULL>	5620	VAC18193RSV2008 A Randomized, observer-blind, phase 1 study to evaluate innate and pro-inflammatory responses of an Ad26.RSV.preF-based vaccine, Ad26.COV2.S vaccine and Ad26.ZEBOV vaccine in adults aged 18 to 59 years	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2022-11-03	Janssen Vaccines &amp; Prevention B.V	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4dk4rss	<NULL>	Participant must have a body mass index less than 35.0 kilograms per meter square. In the investigator’s clinical judgment, participant may have a stable and well-controlled medical condition including comorbidities associated with an increased risk of progression to severe coronavirus disease-2019, as long as their symptoms and signs are stable at the time of vaccination, and these conditions receive routine follow-up by the participant’s healthcare provider. Participants will be included on the basis of relevant medical history, vital signs, and body mass index measurement at screening. - Participant agrees to not donate bone marrow, blood, and blood products from the first study vaccine administration until 3 months after receiving the last dose of study vaccine. Before randomization, participants must be either: (a) Not of childbearing potential; (b) Of childbearing potential and practicing an acceptable effective method of contraception and agrees to remain on such a method of contraception from signing the consent until 3 months after the last dose of study vaccine (including optional Ad26.COV2.S vaccination on Day 29 in Groups 2 and 3). Use of hormonal contraception should start at least 28 days before the first administration of study vaccine	Participant has a history of malignancy within 5 years before screening (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix, or malignancy, which is considered cured with minimal risk of recurrence). Participant has a known or suspected allergy or history of anaphylaxis or other serious adverse reactions to vaccines or their excipients (including any of the excipients of the study vaccine, or trace residues [chicken and/or egg proteins, gentamicin]). Per medical history, participant has chronic active hepatitis B or hepatitis C infection. Per medical history, participant has human immunodeficiency virus type 1 or type 2 infection. Participant has a history of acute polyneuropathy (example, Guillain-Barré Syndrome) or chronic inflammatory demyelinating polyneuropathy. Participant has abnormal function of the immune system resulting from: (a) Clinical conditions (example, autoimmune disease or immunodeficiency) expected to have an impact on the immune response elicited by the study vaccine. Participants with autoimmune disease (example, autoimmune-mediated thyroid disease, autoimmune inflammatory rheumatic disease such as rheumatoid arthritis, and Type 1 diabetes) that is stable and inactive without the use of systemic immunomodulators, and glucocorticoids may be enrolled at the discretion of the investigator; (b) Use of systemic corticosteroids within 2 months before administration of the first study vaccine until 28 days after first study vaccination. A substantial immunosuppressive steroid dose is considered to be greater than (&gt;) 2 weeks of daily receipt of 20 milligrams (mg) prednisone or equivalent. Note: Ocular, topical, or inhaled steroids are allowed; (c) Administration of antineoplastic and immunomodulating agents, example, cancer chemotherapeutic agents, or radiotherapy within 6 months before administration of study vaccine until 28 days after first study vaccination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-469yd6	Transcranial Direct Current Stimulation (tDCS) and its therapeutic effects on Chikungunya Fever	Not yet recruiting	Intervention	2018-06-25	<NULL>	<NULL>	5622	Transcranial Direct Current Stimulation (tDCS) and its therapeutic effects on Chikungunya Fever: phase II	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-469yd6	<NULL>	Man or woman aged 18 or older; be in chronic phase of chikungunya fever least 3 month of the initial infection and show laboratory tests or clinical diagnostic confirmation of chikungunya virus; pain related with more than 4 in a numeric rating scale; to have physical capacity to do physical evaluation and be capable of consenting to treatment and understanding study explanations and questionnaires; having provided informed consent	Electrical implants in the body; a history of epilepsy; people who are clinically contraindicated to receive transcranial direct current stimulation such as having metal embedded in their scalp or brain; psychiatric illness, and history of drug abuse; pregnant women; signs of severity and indication of hospitalization; presence of previous rheumatic disease including gout, rheumatoid arthritis, fibromyalgia, lupus and others chronic pain syndromes with diagnosis prior to chikungunya	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-4b5dsg	Evaluation of the efficiency of different schemes of Pre-operative Analgesia in Oral Surgeries	Not yet recruiting	Intervention	2018-12-21	<NULL>	<NULL>	5627	Evaluation of the efficacy of different protocols of Preemptive Analgesia in Oral Surgeries	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4b5dsg	<NULL>	For periodontal surgeries patients with periodontitis and need for open flap periodontal surgery for scaling and root planing; patients with good systemic health ASA I or II who do not make continuous use of any analgesic and anti-inflammatory medication could bring some kind of bias to the study outcomes; patients with absence of pain; for dental implant surgeries patients with need of bone-integrated dental implant diameter 3.5 mm or 3.75 mm height 10 or 13 mm with the site presenting 2 mm of keratinized gingiva and 10 mm of vertical bone and more than 5 mm of vestibular-lingual bone; patients with good systemic health ASA I or II who do not make continuous use of any analgesic and anti-inflammatory medication that could bring some kind of bias to the study outcomes; patients with absence of pain and signs of oral infection.	Pregnant or lactating mothers; asthmatics; history of allergy or intolerance to the drugs and other substances or materials used in the present research; patients with a history of kidney or liver problems; patients with blood dyscrasias; history of the use of drugs with analgesic or anti-inflammatory properties within 7 days before surgery; patients taking bisphosphonates and other anti-resorptive agents; cases in which the duration of the surgery or number of anesthetics exceeds the average time that will be standardized, trans or postoperative complications; patients who do not respond to the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-10m7c788	Effect of Platelet-Rich Fibrin on the stability of Bone Graft and soft tissues around dental implants: a randomized clinical trial	Not yet recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5631	Guided Bone Regeneration in the maxilla with the use of Xenogeneic Graft associated or not with Platelet-Rich Fibrin: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade Paulo Picanço	Faculdade Paulo Picanço	https://ensaiosclinicos.gov.br/rg/RBR-10m7c788	<NULL>	Volunteers aged between 20 and 80 years; both genders	Partially dentate volunteers; with jaws without adequate bone height; uncontrolled systemic disease; smokers; history of radiation in the treatment area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-88hrnnw	Effect of Rosemary on sleep, mood status and cardiovascular risk in emergency nursing: intervention study	Not yet recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5635	Effectiveness of Rosemary on sleep, affectivity and cardiovascular risk in emergency nursing: a quasi-experimental study	<NULL>	2-3, n/a, open	2-3	<NULL>	<NULL>	<NULL>	2022-10-03	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-88hrnnw	<NULL>	Nursing assistants; nursing technicians; nurses; work in emergency services (emergency care unit and hospital emergency department) for at least one month; aged 30 years or older; under any form of contract	Hypersensitivity to Rosemary; pregnant women; lactating women; epileptics; dyslipidemia treatment; diabetes mellitus treatment; biliary or hepatic dysfunction; prostatic diseases; gastroenteritis; those with hair &lt; 2 cm in the region of the posterior vortex of the head; use of topical medication on the scalp; or away from work for any reason during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-53643h8	Effect of Hygiene Devices on the healing of Inflammation around dental implants	Not yet recruiting	Intervention	2022-09-26	<NULL>	<NULL>	5639	Effect of Hygiene Devices on the healing of Peri-implant Mucositis lesions: a parallel randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-53643h8	<NULL>	Age greater than or equal to eighteen years; Implants in function for more than a year; Diagnosis of peri-implant mucositis, defined as: Presence of visual signs of peri-implant inflammation combined with profuse bleeding on probing (line or drop) and/or suppuration at two or more sites, probing depths of four to five mm and no detectable bone loss	Absence of adjacent teeth; No contact point with adjacent teeth; Implants diagnosed with peri-implantitis; Patients in which the Curaprox IAP Probe cannot be used due to lack of space; Full-arch or removable implant-supported rehabilitation; Fixed implant-supported rehabilitation (multiple prosthesis); Implants with inadequate hygiene access or marginal misfit; Individuals with limited manual dexterity, making self-administered implant hygiene impossible; Presence of active periodontal disease; Heavy smokers; Patients with transmissible diseases or critical medical conditions such as, but not limited to: uncontrolled diabetes, AIDS, bone disease and rheumatic fever; Conditions requiring prophylactic antibiotic coverage prior to dental treatment; Pregnancy or breastfeed; Any known allergies to the components of the supplied products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-10kpgx78	A package of social media material targeting low back pain beliefs in the general community: a randomized controlled trial.	Not yet recruiting	Intervention	2022-09-28	<NULL>	<NULL>	5640	Effect of a digital pain education material on beliefs and attitudes about low back pain in the general community: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10kpgx78	<NULL>	Adults residing in Brazil; aged 18 years old or over; able to speak Portuguese; know how to read and understand reading in the Portuguese language; have access to the internet.	Not applicable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7kh27st	Cognitive-Evolutionary Group Therapy	Not yet recruiting	Intervention	2022-09-29	<NULL>	<NULL>	5641	Efficacy of Cognitive-Evolutionary Group Therapy for Depression: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-7kh27st	<NULL>	Aged at least 18 years old; have mild or moderate depression, expressed as a score of at least 9 to 20 on the Patient Health Questionnaire-9 (PHQ-9), without suicide risk evaluated by the Structured Clinical Interview for DSM-5 (SCID-5); have Internet at home and a computer or any electronic device connected to the Internet in order to access the free platform of Google meet; filled out the mandatory inform consent.	Having hypothyroidism due to being a cause of organic depression related to hormone levels; having suicide risk evaluated by the Structured Clinical Interview for DSM-5 (SCID-5); having severe depression (score &lt; 20 or more on the PHQ-9); having a medical disorder that would interfere to participating; having substance abuse (alcohol and others drugs), psychosis, anxiety or panic disorder out of context of depression, personality disorders (obsessive-compulsive and borderline disorder); bipolar disorder; be under psychological treatment by the time of the recruiting.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-8s5vqbb	Clinical evaluation of Resin Restorations in teeth with abfraction	Not yet recruiting	Intervention	2022-09-30	<NULL>	<NULL>	5644	Clinical evaluation of direct Adhesive composite resin Restorations in abfraction dental lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-08	Universidade do Estado do Rio Grande do Norte	Faculdade de Enfermagem e Medicina Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-8s5vqbb	<NULL>	Patients of both biological sexes; age between 18 and 50 years; good general health and satisfactory oral hygiene; with at least 20 teeth; with dental retainer; diagnosis of at least two abfraction lesions with at least 1 mm of depth, in different premolars located in different hemi-arches, in occlusion and which have opposing teeth; sound premolars or with satisfactory restorations in an area different from the abfraction lesion; no nearby gingival inflammation or periapical changes	Patients in need of use of dental prosthesis with the edentulous space adjacent to the dental elements that could be included in the research; caries diagnosis coinciding with the abfraction lesion or endodontic treatment indication; diagnosis of severe parafunctional habits; presence of moderate or severe periodontal involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-3g655ht	Infant motor profile: portuguese translation and data of Brazilian population	Not yet recruiting	Observational	2022-10-03	<NULL>	<NULL>	5645	Infant motor profile: portuguese translation and normative data	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-30	Eloisa Tudella	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3g655ht	<NULL>	Brazilian infants. Both genders. Chronological age between 3 and 18 months old. Infants whose parents or legal guardians consent to participation by signing the Free Consent and Clarified Term.	Infants whose parents and legal guardians cannot understand the Free Consent and Clarified Term and the Portuguese language.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-89z5hb7	Effect of the medication buspirone hydrochloride on teeth grinding as a side effect of anxiety: a previous study	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5648	Effect of buspirone hydrochloride on awake bruxism as a somatic manifestation of anxiety: a pilot study	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2022-11-30	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-89z5hb7	<NULL>	female volunteers, over 18 years old, diagnosed with definitive awake bruxism	participants who do not agree to participate in this study or who have some cognitive difficulty that prevents them from answering the questionnaires; under 18 years old; individuals with epilepsy; with acute intoxication and/or chronic use of alcohol, hypnotics, analgesics, or antipsychotic drugs; with severe kidney and liver failure; history of seizure; current illness or history of serious neurological or psychiatric disorders; history of chronic musculoskeletal pain; previous diagnosis or signs and symptoms of other chronic temporomandibular disorders; use of prescription drugs or drugs with possible effects on sleep or changes in motor behavior or drug interactions with buspirone hydrochloride; smoking; currently undergoing medical or dental treatment; with some dental characteristics, such as loss of more than two posterior teeth, except third molars and users of complete dentures, removable partial dentures and orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-5cjpz86	Effectiveness of hot tub bath in pain of hospitalized children	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5649	Effectiveness of hot immersion bath in pain management of hospitalized children: Randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5cjpz86	<NULL>	Children who meet the following criteria will be included in the study: Children between 28 days and 2 years old, hospitalized in the Pediatric Inpatient Unit/Ward for respiratory problems; Children with pain, evaluated by validated scales: Neonatal Infant Pain Scale (NIPS), whether it is: severe, moderate or mild pain; or Face, Legs, Activity, Cry, Consolability (FLACC), be it: severe, moderate or mild pain; Have the permission of their parents or guardians to participate in this study. In addition to these criteria, the inclusion of the same child within 12 hours of the last inclusion in the study will also be allowed if the child is not under the influence of pain management medications and the last medication for this purpose was taken within 6 hours, considering the time of action of the most used drugs.	Exclusion criteria will be: Children over 2 years of age; Children using positive pressure ventilation (CPAP); Children awaiting transfer to the Intensive Care Unit (ICU) due to worsening respiratory distress, since the immersion bath can cause crying and irritability and the condition worsens; Children who have taken any medication for pain management within 6 hours of pain detection using the validated scales; Children with a previous diagnosis of chronic pain. It is worth mentioning that there are medications that are used both for pain management and for other conditions, for example dipyrone, which in addition to being an analgesic also has antipyretic properties, and can be used in the management of fever. Thus, the researcher at the time of collection will pay attention to the medications that were previously administered to the child and whether they have analgesic properties, in order to avoid inclusion bias. If they also act in pain management, the medication must have been administered within a 6-hour interval prior to the moment of pain detection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-6pq5f74	Effects of a Physical and Cognitive Exercises program in community-dwelling elderly gait	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5650	Effects of a dual-task Exercises Program in community-dwelling elderly gait	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6pq5f74	<NULL>	60 years of age or older; live in Porto Alegre; be available to participate in the program on the days and times established; be physically independent	To have physical limitations that make it impossible to perform the proposed exercises; having uncontrolled chronic diseases; disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-36w6cbr	Effect of task training on prevention of arm contracture in subjects after Stroke – a feasibility study	Not yet recruiting	Intervention	2022-10-06	<NULL>	<NULL>	5652	Effect of task-specific training in the prevention of upper limb contracture in individuals after Stroke- a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-36w6cbr	<NULL>	Individuals aged 18 years or older; clinical diagnosis of stroke (first episode); presence of lacunar infarction; be within the period of up to 10 days after stroke; unilateral clinical signs (hemiparesis with muscle weakness of the upper limb greater than or equal to 10%, confirmed by the average of three measurements of handgrip strength performed with a dynamometer); ability to respond to simple commands, such as “put your hand on your head” and “raise your arm” performed with the non-paretic limb; and who reside in the metropolitan region of Belo Horizonte.	Presence of orthopedic conditions in the upper limbs or others that prevent measurement proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-6z857dk	Nursing Intervention in the Glycemic Control of the Elderly	Not yet recruiting	Intervention	2022-10-07	<NULL>	<NULL>	5654	Evaluation of the effectiveness of a nursing intervention based on the Theory of Dorothea Orem&apos;s self-care deficit in the glycemic control of elderly people with type 2 diabetes mellitus: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade de Brasília	Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6z857dk	<NULL>	Age over 60 years; have at least six months and a maximum of 10 years of diagnosis of type 2 diabetes mellitus to be confirmed in the electronic medical record; be registered at the basic health unit; have a cell phone with access to an instant messaging application; have long availability to attend the study; and be able to understand, verbalize and respond to proposed questions.	Diagnosis of type 1 diabetes mellitus; being insulin dependent; having chronic complications of diabetes mellitus (nephropathy, retinopathy, limb amputation and diabetic foot); have mobility limitations; and not knowing how to read and write.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-107w28wf	The use of an intermediate flowable base in restorations of endodontically treated premolars	Not yet recruiting	Intervention	2022-10-10	<NULL>	<NULL>	5656	Clinical evaluation of posterior composite restorations placed with an intermediate flowable base in endodontically treated premolars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-20	Pontificia Universidade Católica de Paraná	Pontificia Universidade Católica de Paraná	https://ensaiosclinicos.gov.br/rg/RBR-107w28wf	<NULL>	Adult patients who underwent endodontic treatment in the past 30 days and currently have a temporary restoration in upper premolars. The teeth should have at least the buccal and lingual walls remaining and occlusal contacts in the teeth included in the study	Patients with teeth in need of indirect restorations due to significant loss of tooth structure, parafunctional habits, absence of the antagonist teeth, tooth mobility, and periodontally compromised condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3rqcxqd	Benefits of Morphine gel for pain reduction in patients with Cancer Wounds	Not yet recruiting	Intervention	2022-10-13	<NULL>	<NULL>	5660	Effectiveness of Topical Morphine use in patients with painful Neoplastic Wounds in the breast and head and neck: double blind randomized clinical trial - MorphineGel	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-11-01	Escola de Enfermagem Aurora de Afonso Costa	Instituto Nacional de Câncer José Alencar Gomes da Silva - Hospital do Câncer IV	https://ensaiosclinicos.gov.br/rg/RBR-3rqcxqd	<NULL>	Patient enrolled in the unit; primary or metastatic breast or head and neck disease of any histological type; malignant neoplastic wound with stage II or greater; 18 years of age or older; karnofsky performance status greater than or equal to 30%; have at least 3 on the pain intensity scale; admission time of 48 hours or more; using systemic morphine	Fistulated wound; wound with extensive coagulation necrosis (more than 50% of the wound area); wound with exudation greater than 1 (pressure ulcer scale for healing); wound with bleeding greater than 1 (validated intraoperative bleeding scale); radiotherapy in progress in the wound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-2x6hmbv	Consequences of Covid19 on the cardiovascular system of hypertensive patients	Not yet recruiting	Intervention	2022-10-14	<NULL>	<NULL>	5662	Consequences of Sars-Covid19 on the cardiovascular autonomic control of hypertensive patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-27	Faculdade de Medicina de Ribeirão Preto - FMRP/USP	Faculdade de Medicina de Ribeirão Preto - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-2x6hmbv	<NULL>	Homens; hipertensos ou normotensos; idade entre 35 e 55 anos; acometidos por COVID-19 entre 6 e 24 meses antes; assintomático, leve ou internados em enfermaria por baixa saturação de oxigênio	Smokers; diagnosis of cognitive disturbances, musculoskeletal disorders, and chronic diseases; during the period of transmission of the Covid-19 disease; patients who had the severe form and required ICU admission; previous home or outpatient physical therapy treatment; current use of drugs that interfere with cardiac functionality and cardiovascular autonomic control	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-5dhhhdd	Clinical evaluation of the antidepressant effect of the use of probiotics in bipolar disorder	Not yet recruiting	Intervention	2021-10-15	<NULL>	<NULL>	5671	Clinical evaluation of the antidepressant effect of the use of probiotics in bipolar disorder and possible mediating effects of systemic and Intestinal Inflammatory markers in the microbiota	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dhhhdd	<NULL>	Bipolar disorder type I or type II; score on the YMRS scale less than 8; score on the MADRS scale greater than 8	"Pregnant or lactating women; patients dependent on alcohol and illicit drugs like marijuana, crack or cocaine; patients on prolonged antibiotic therapy; immunosuppressive therapies; introduction of recent antidepressants up to 15 days from the beginning of the study; HIV carriers with manifestations of the syndrome
of acquired immunodeficiency and serious clinical diseases; with delayed mental or inability to understand the study instructions will be excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-6fm2x4d	Use of blood concentrates to control pain, swelling and postoperative mouth opening difficulties in mandibular wisdom teeth extractions	Not yet recruiting	Intervention	2022-10-20	<NULL>	<NULL>	5675	Use of blood concentrates in the control of pain, edema and postoperative trismus following lower third molar removal: a triple blind randomized clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-04	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6fm2x4d	<NULL>	Will be included in the study, 28 patients aged between 18 and 30 years and without impairment of general health according to medical history (healthy) and physical examination who agree to participate in the study. Through clinical and radiographic examination, asymptomatic patients with indication for bilateral extraction of mandibular third molars will be selected, in class IIB position, according to Pell &amp; Gregory&apos;s classification.	Exclusion criteria will be considered: (I) history of use of any type of medication in the 15 days prior to the start of the surgical procedure; (II) history of hypersensitivity to drugs, substances or materials used in this experiment; (III) pregnancy or lactation; (IV) pericoronitis or other local infection within 15 days prior to the surgical procedure; (V) people with a history of systemic disease, such as hypertension, diabetes, or diseases with high oxidative stress, such as favism, severe anemia), (VI) and time of the shortest intervention less than 75% of the time elapsed in the longest intervention long.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-7gsnvdv	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Intervention	2022-10-21	<NULL>	<NULL>	5677	Assessment of gynecological and dermatological acceptability of a helth product in normal conditions of use_Ave01.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-03	Avenca Indústria Cosmética Eireli -EPP	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7gsnvdv	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; discharges; Immunodeficiency carriers; Kidney, heart or liver transplants; Active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-55wtdr8	Evaluation of Magnesium Sulfate in Pain Relief in burn victims	Not yet recruiting	Intervention	2022-10-25	<NULL>	<NULL>	5681	Evaluation of the Analgesic Effect of Magnesium Sulfate in burn patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Fundação de Ensino e Pesquisa em Ciências da Saúde/ FEPECS/ SES/ DF	Hospital Regional da Asa Norte	https://ensaiosclinicos.gov.br/rg/RBR-55wtdr8	<NULL>	Patients admitted to the burn treatment unit who will undergo balneotherapy and dressing change; of both genders; age between 18 and 59 years; classified in physical states I and II (according to the classification of the American Society of Anesthesiology); with 10 -20% burned body surface area; with more than 24 hours and less than 72 hours of hospitalization	Readmitted patients; outpatient balneotherapy/dressing; illicit drug users; previous pain syndromes; cognitive impairment; allergic to any component of the study; psychiatric disorders; pharmacodermia; myasthenia gravis; heart disease; hypermagnesemia; pregnant women; lactating women and creatinine elevation (&gt;1.2 mg/dl)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-43hpwqk	Online Psychological Interventions to improve Well-Being - OPIW	Not yet recruiting	Intervention	2022-10-27	<NULL>	<NULL>	5686	Positive Psychology-based Interventions for Telehealth in a pandemic context: Well-being and emotional health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-03	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-43hpwqk	<NULL>	Healthy volunteers; both genders; ages between 18 and 60 years; access to internet and a mobile device with android operating system; being a national resident in Brazil; voluntary acceptance and consent to participate in the study	Volunteers with a psychiatric diagnosis; presents mental health problem	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-5wqbzx8	Assessment of cardiac measurements, blood sugar levels and psychological parameters of people with Diabetes Mellitus who practice Physical Exercise	Not yet recruiting	Intervention	2022-11-01	<NULL>	<NULL>	5694	Evaluation of cardiovascular, glycemic and psychophysiological parameters of people with Diabetes Mellitus who practice Physical Exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto Mantenedor de Ensino Superior da Bahia	Centro Universitário de Excelência - UNEX	https://ensaiosclinicos.gov.br/rg/RBR-5wqbzx8	<NULL>	Volunteers with type I or type II diabetes mellitus, female or male; age between 18 to 45 years	Volunteers who have neuropathy developed by diabetes, a history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; suffer some type of muscle injury that prevents the practice of physical exercises; individuals who during the research period fail to show up for physical tests or exercise sessions and who are not available for a new day/time to perform the procedures; who have medical restrictions for the practice of physical exercise or any type of secondary disease that may be aggravated due to participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-728v4h3	Verification of the vertical jump performance of volleyball athletes after Forced stretching of lower limbs	Not yet recruiting	Intervention	2022-11-03	<NULL>	<NULL>	5697	Verification of the acute effect of the Forced stretching of the lower limb musculature on the vertical jump height gain in volleyball athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-29	Erickson Zacharias Barboza	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-728v4h3	<NULL>	The project foresees the participation of 30 healthy participants; male; between 18 to 50 years of age; body mass index greater than 18 less than 25 kilograms per square meter; residents in the city of Florianópolis; volleyball players regularly	Will be removed who have any type of disease that prevents the vertical jump; athletes aged under 18 and over 50; athletes who have already had experience with the use of the stretching technique with proprioceptive neuromuscular facilitation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-49zrxsx	Surgical distance Mentoring versus face to face Mentoring in the training of Scleral Fixation surgeries for intraocular lenses	Not yet recruiting	Intervention	2022-11-04	<NULL>	<NULL>	5702	Telementoring versus Presential Mentoring in the Training of Scleral Fixation surgeries for intraocular lenses	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-04	Universidade Federal de São Paulo	Alcon Brasil cuidados com a saúde LTDA	https://ensaiosclinicos.gov.br/rg/RBR-49zrxsx	<NULL>	Ophthalmologist volunteers; both genders; no age restrictions; no previous experience with the scleral fixation technique of the Akreos lens with GoreTex sutures	Ophthalmologist volunteers with previous experience in the technique of scleral fixation of the 4-haptic scleral lens fixation (Akreos® - Bausch Lomb) using polytetrafluoroethylene sutures (GoreTex®)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-4q3xpdt	Lymphatic Drainage and Taping  in the treatment of edema in pregnant women	Not yet recruiting	Intervention	2022-11-04	<NULL>	<NULL>	5703	Lymphatic Drainage and Taping  in the treatment of edema in pregnant women: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-20	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4q3xpdt	<NULL>	Pregnant women at usual risk (normotensive, without cardiac or vascular pathologies, pulmonary, without high cholesterol levels, gestational diabetes or renal failure); age group between 18 and 34 years; being between the twenty-seventh and thirty-eighth week of gestation; edema in the lower limbs	Present skin lesions in the area of the lower limbs that make manual lymphatic drainage or taping application impossible; not attending sessions; not complete the assessment procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-10myxdss	Comparative study of self-report scales in cancer patients undergoing oral antineoplastic medications such as tyrosine kinase inhibitors	Not yet recruiting	Intervention	2022-11-07	<NULL>	<NULL>	5706	Use of the patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE) short version and MDASI in patients with Cancer patients submitted to oral antineoplastic medications such as Tyrosine Kinase Inhibitors: a comparative study of the 2 scales	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de São Paulo	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10myxdss	<NULL>	older than 18 years; being treated with TKI alone as anticancer therapy, orally and for 3 months or more; being diagnosed with one of three cancers: kidney, lung, or chronic myeloid leukemia; Performance status between 0 and 2, evaluated according to the Eastern Cooperative Oncologic Group – ECOG scale	multiple comorbidities (3 or more), partial completion of one of the data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-7xhvw6n	Effect of Neuromodulation associated with Gametherapy on upper limb function and brain activity in children with Down Syndrome: double-blind, placebo-controlled, crossover clinical trial	Not yet recruiting	Intervention	2022-11-08	<NULL>	<NULL>	5710	Effect of Transcranial Direct Current Stimulation associated with Gametherapy on function, upper limbs reaching movement and brain activity in children with Down Syndrome: crossed, placebo-controlled and double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-10	Universidade Evangélica de Goiás	Universidade Evangélica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7xhvw6n	<NULL>	Diagnosis of Down Syndrome; adequate understanding and cooperation during proceedings;age between six and twelve years; impairment of upper limb motor coordination and declaration of free and informed consent signed by a legal guardian; neurotypical; adequate understanding and cooperation during proceedings; age between six and twelve years; declaration of free and informed consent signed by a legal guardian, consent form signed by the child.	Children who have undergone surgical procedures in the twelve months prior to the beginning of the training sessions; orthopedic deformity of the lower limbs or spine with surgical indication; uncontrolled epilepsy; metallic implant in the skull or hearing aids; associated neurological disorder; and pacemaker use; associated neurological disorders, bone deformity in the lower and upper limbs, uncorrected visual deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-2zd2rgy	Effects of moderate training and high-intensity training on measures of metabolism and liver health in adults	Not yet recruiting	Intervention	2022-11-08	<NULL>	<NULL>	5711	Effects of Continuous Moderate Intensity Training and High Intensity Interval Training on physiological and pathological makers of Metabolic Syndrome and hepatic health in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto de Pesquisa da Capacitação Física do Exército	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2zd2rgy	<NULL>	Male sex; military personnel from the Army Physical Training Center and/or from the 1st Guards Battalion; submitted to a weekly nutritional control; and signature on the free and informed consent term.	military personnel who have undergone any type of abdominal surgery, or with any type of osteoarticular or musculoskeletal injury and other clinical conditions that prevent them from performing any of the assessments, which limit movements or who are undergoing restrictive medical treatments; Military personnel who are using any substance or drug capable of altering the test results; Military personnel who are unable to attend all stages of data collection or who are considered physically unfit by a previous medical assessment, especially cardiopulmonary health assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-9gdssk9	Distance-Oriented Exercises for patients with Cystic Fibrosis	Not yet recruiting	Intervention	2022-11-09	<NULL>	<NULL>	5713	Telerehabilitation of individuals with Cystic Fibrosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-30	Faculdade de Educação Fisica e Fisioterapia	Hospital de Clínicas da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9gdssk9	<NULL>	Patients with a confirmed diagnosis of cystic fibrosis; age between 12 and 34 years; with a Shwachman Kulczycki (SK) severity score greater than 7 (less severe disease); who agree to participate in the research; that have pulse oximeter monitoring available and internet access via cell phone or computer	Patients with significant cognitive and or orthopedic alterations; comorbidities that limit physical activity; pregnant women; patients who did not perform the exercise protocol for more than one week; those who for some reason do not keep in touch via cell phone or computer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-6prps8g	HOTFy: randomised clinical trial to Hyperbaric Oxygen Therapy in Fibromyalgia	Not yet recruiting	Intervention	2022-06-17	<NULL>	<NULL>	5718	HOTFy: randomised clinical trial to Hyperbaric Oxygen Therapy in Fibromyalgia	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6prps8g	<NULL>	ages between 18-70 years; diagnosis of fibromyalgia at least 2 years prior to enrollment based on one of two criteria: symptoms of generalized pain occurring above and below the waist and affecting the right and left sides of the body for at least 3 months and not having another somatic disorder that warrants the symptoms and/or presence of at least 11 of the 18 tender points (“Tender Points”).	contraindications for hyperbaric oxygen therapy (pregnancy, use of bleomycin, cisplatin, disulfiram and doxorubicin, middle ear surgery, untreated pneumothorax or pneumomediastinum, claustrophobia); associated autoimmune rheumatologic disease and inability to sign the informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-57v9mrb	Comparison between models of resistance training volume progression on strength and muscle mass	Not yet recruiting	Intervention	2022-11-10	<NULL>	<NULL>	5719	Comparison of volume load progression models in Resistance training in strength gains and muscle hypertrophy: a within-subject randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-57v9mrb	<NULL>	Healthy young people; both sexes; age between 18 and 35 years	Have practiced resistance training in the last 6 months; Musculoskeletal injury of lower limbs; neuromuscular disorders that may prevent the execution of the protocols proposed by the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-4q69573	Transcranial Electrical Stimulation for chronic pain relief in individuals with Endometriosis	Not yet recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5720	Transcranial Direct Current Electrostimulation for chronic pain relief in individuals with Endometriosis: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4q69573	<NULL>	Age range from 18 to 40 years; diagnosis of endometriosis; having a pain score greater than 3; cognitive ability to understand and answer questionnaires; tolerance to electrical stimulation treatment	Severe headache; dizziness or migraine; having other chronic urinary tract and/or gynecological diseases; being in the puerperal period; be breastfeeding; having a history of brain surgery; presence of tumors; having epileptic disease; have a history of alcohol or drug abuse; have metal implants in the head; have a history of previous gynecological surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-7dm3sp7	Clinical evaluation of Restorations in Anterior Teeth with Composite Resin using the cloud shades concept	Not yet recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5723	Clinical evaluation of Restorations in Anterior Teeth with Composite Resin using the cloud shades concept: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-02	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7dm3sp7	<NULL>	Two anterior permanent teeth requiring restorations in each patient (two class III or two class IV), large cavities or defective restorations with similar dimensions and including the same number of tooth surfaces; presence of the antagonist and opposing teeth making contact; vital pulp; good oral health, age between 18 and 70 years; both genders	Extremely deep caries lesions, unrestorable crown; mechanical pulp exposure during caries removal; teeth previously treated with direct pulp capping; teeth exhibiting spontaneous or constant pain indicating irreversible pulpitis; severe systemic diseases; allergies to dental composites; periodontal disease; deleterious parafunctional habits and bruxism; hypersensitivity on the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-104xsgky	Effects of the Animal Fun Program on movement and psychosocial performance in children aged between 4 and 6 years	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5724	Effects of the Animal Fun Program on motor and psychosocial performance in children aged between 4 and 6 years	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104xsgky	<NULL>	Children aged 4 to 6 years old can participate in the Animal Fun programme; enrolled; signed informed consent form (TCLE) and assent form (TELE).	not being able to perform the Movement Battery Assessment for Children (MABC-2).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-104bdhff	Zinc supplementation in patients with Head and Neck Cancer in Radiotherapy	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5726	Effectiveness of Zinc supplementation on Dysgeusia in patients with Head and Neck Cancer submitted to Radiotherapy: a randomized clinical test protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-15	Liga Norte Riograndense Contra o Câncer	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-104bdhff	<NULL>	Patients with head and neck cancer; age between 19 and 65 years; under radiotherapy treatment, of both genders.	Gastrointestinal tract disorders; exclusive alternative food route, such as total parenteral nutrition (TPN) and enteral nutritional therapy (ENT); Exocrine pancreatic insufficiency; Tongue or palate demolition surgery; Sjögren&apos;s syndrome, considering that the pathophysiology of this disease can affect the salivary glands and impair taste; Diagnosis for Covid-19 with presence of dysgeusia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-2frpntv	Development of a Protocol for using Steroids after Cataract Surgery	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5727	Development of a Cost-effective Corticosteroids Protocol in the postoperative Cataract Surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto para o Desenvolvimento da Educação Ltda-IPADE/Faculdade	Universitary Center Christus (Centro Universitário Christus - Unichristus)	https://ensaiosclinicos.gov.br/rg/RBR-2frpntv	<NULL>	Patients with cataracts; Over 18 years old; Patients from Instituto Cearense de Oftalmologia cataracts department; Patients who do not have other eye conditions that cause eye inflammation, increased intraocular pressure, decreased visual acuity and macular edema, including diabetic retinopathy; Patients who accepted to participate the study signed the informed consent form.	"Ocular affections which cause inflammation, elevated intraocular pressure, reduced vision acuity and macular edema; Allergy to corticosteroids; Any condition that could interfere to the correct use of the eye drops, including patient&apos;s social and/or economic situation; Use of any eye drops, except lubricants
Ocular or systemic use of Non-steroidal anti-inflammatory drugs, corticosteroids, immunosuppressives or anti-histaminics 2 days before to 21 days after the surgery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-8wd82p8	Effect of Osteopathic treatment for patients with knee Arthrosis	Not yet recruiting	Intervention	2022-11-17	<NULL>	<NULL>	5731	Effects of Visceral Manipulation associated or not with Structural Techniques on pain, range of motion, activation and muscle strength of individuals with knee Osteoarthritis: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto Docusse de Osteopatia e Terapia Manual	Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-8wd82p8	<NULL>	To be included in this study, participants must be over 40 years-old; medical diagnosis of knee osteoarthritis; pain for more than three months; have at least one of the following symptoms: limited range of motion, crepitus, difficulty/pain when going up and down stairs, walking, standing up or sitting in a chair	Exclusion criteria for the present study are history of knee surgery; presence of rheumatoid arthritis; initiation of opioid analgesia or intervention with corticosteroid injection or analgesic for knee pain within the last 30 days; inability to understand and complete study assessments or comply with study instructions; neurological diseases that could influence the investigated outcomes (e.g., stroke)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-10b6jkd2	The effect of Speech Therapy associated to Laser Therapy on swallowing in the elderly	Not yet recruiting	Intervention	2022-11-18	<NULL>	<NULL>	5733	Controlled and randomized clinical study of the effect of Orofacial Myotherapy associated with Photobiomodulation in elderly with presbyphagia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-10b6jkd2	<NULL>	Seniors; age over 60 years; complaints of difficulty in chewing and/or swallowing (Dysphagia)	Individuals with neurological diseases; elderly with cognitive impairment; head and neck tumor resection surgery; tracheostomized patients; patient with pathology in the thyroid region; elderly people with mobility difficulties or need for a companion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-8ywgvm8	The effect of an App for cell phones and tablets on the blood glucose of elderly people with Type 2 Diabetes	Not yet recruiting	Intervention	2022-11-21	<NULL>	<NULL>	5737	Effectiveness of a mobile device Application on glycated hemoglobin in elderly people with Type 2 Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-06	Universidade de Brasília - Faculdade de Ceilândia	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-8ywgvm8	<NULL>	Elderly aged between 60 and 75 years of both sexes; literate; access to electronic mobile devices; Internet access; medical diagnosis of type 2 diabetes for at least one year; use of oral medication for type 2 diabetes; able to have independence and autonomy to perform activities of daily living that will be measured by the Barthel index; in need of adaptation or supervision by third parties to carry out activities of daily living; who do not practice physical activity or who have insufficient physical activity, assessed using the International Physical Activity Questionnaire (IPAQ) short version	Elderly people using insulin; with multiple chronic comorbidities such as cancer, rheumatoid arthritis, congestive heart failure, severe depression, emphysema, Parkinson&apos;s disease, myocardial infarction, stroke, class III chronic renal failure or worse, end-stage disease such as metastatic cancer, class 4- 5, chronic lung disease requiring oxygen therapy, dialysis patients, severe functional and cognitive impairment; participants in another clinical trial, research study, or exercise program in which they perform similar balance and strength activities; have mobility limitations or use walking devices; diagnosis of progressive neurological disease or other acute or unstable medical condition that prevents exercise; cardiac risk classification II, III and IV according to the New York Heart Association (NYHA) Functional Classification	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-7cztcpk	Performance of Physical Exercise on Cognition, Creativity and Performance in Childrens and adults	Not yet recruiting	Intervention	2022-11-21	<NULL>	<NULL>	5738	Effects of Physical Exercise on Cognition, Creative Thinking and Occupational Performance in childrens and adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Fisioterapia e Terapia Ocupacional da Universidade Federal do Pará	Faculdade de Fisioterapia e Terapia Ocupacional da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7cztcpk	<NULL>	Healthy participants; age between 08 to 59 years; both genders; assets in the educational institution; accept sign the Free and Informed Consent Term (FICT) to participate in the study, in case of participants under 18, the consent form must be signed by the legal guardian	Participants with cardiac, neurological or physical pathologies; under 8 years old and over 59 years old; who use drugs that influence the central nervous system; licit and/or illicit drug users; who do not agree to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-6vb9gn4	Hemolysis after Transfusion of Packed Red Blood Cells by Peripherally Inserted Central Catheter in neonates: randomized clinical trial	Not yet recruiting	Intervention	2022-11-22	<NULL>	<NULL>	5740	Alteration of Hemolysis markers in Packed Red Blood Cell Transfusion using PICC in newborns: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6vb9gn4	<NULL>	Newborns with Peripherally Inserted Central Catheter (PICC) admitted to the Neonatology Service; both sexes with a medical prescription for transfusion of packed red blood cells (pRBCs)	Newborn who has not had blood collected within 24 hours after transfusion; Newborns diagnosed with hemolytic disorders; Newborns receiving vasoactive drug in a single monolumen Peripherally Inserted Central Catheter (PICC); Newborns receiving Total Parenteral Nutrition with osmolarity above 900 milliosmol(mOsm) in a single mono lumen PICC	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-4rj97vw	Evaluation of Surgery for Shoulder Instability with two techniques	Not yet recruiting	Intervention	2022-11-23	<NULL>	<NULL>	5744	Latarjet Surgery: a prospective comparison of the fixation of the screw with and without washer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-13	Centro de Traumatologia do Esporte	Centro de Traumatologia do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-4rj97vw	<NULL>	Patients with anterior shoulder instability; follow-up in the postoperative period for at least 12 months.	Patients with other shoulder associated conditions such as multidirectional instability; posterior shoulder instability; rotator cuff injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-49qbrs4	Mindfulness, self-compassion and associated factors in the context of parenting	Not yet recruiting	Intervention	2022-11-23	<NULL>	<NULL>	5745	Mindfulness, self-compassion and associated factors in the context of parenting: a study protocol for a randomized clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-49qbrs4	<NULL>	Be over 18 years of age; be a parent of children between 0 and 18 years of age; have an electronic device with internet to watch instructional videos with mindfulness practices, as well as to answer the assessment instruments; having interest and availability of time to practice mindfulness; and agree and sign the Free and Informed Consent Term (ICF)	Being a parent with comorbidity that requires intense care; be responsible for a child or other family member with a condition that requires full dedication;  perform other non-pharmacological mental health therapy and  not know how to read and write	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-9sjh5rm	Bone Evaluation of Dental Implants Produced by 3D Printing in Mandible or Maxilla: clinical study	Not yet recruiting	Intervention	2022-11-25	<NULL>	<NULL>	5747	Marginal Bone Level Assessment of Additive-Manufactured Titanium Implants at 30 and 90 Days: 1-year non-inferiority within-subject randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade de São Paulo - Faculdade de Odontologia	M3 Health Indústria e Comércio de Produtos Médicos, Odontológicos e Correlatos Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-9sjh5rm	<NULL>	Patients who are a minimum age of 18 years and a maximum of 70 years; with good general health; who have signed the Informed Consent Form; in need of rehabilitation with dental implants in areas of mandible or posterior maxilla (premolars and/or molars); with bacterial plaque index ≤ 20%; bleeding rate ≤ 20%; sufficient alveolar bone volume for an implant of 8 or 10mm length, diameter of 3.5mm, 4.00mm or 4.5mm, with bone quality type I-III and no associated bone regeneration required	Pregnant and lactating women; uncontrolled diabetes; history of chemotherapy or radiotherapy in the last 5 years; radiation therapy to areas of the head and neck; use of immunosuppressants, bisphosphonates or prolonged use of corticosteroids; smokers; alcohol or drug abuse; untreated periodontitis; history of previous bone augmentate in the implant installation region; presence of residual roots at the site to receive the implant; type IV bone density; individuals with connective tissue disorders or bone metabolic diseases; postmenopausal osteoporosis or other systemic diseases that may affect bone metabolism; need for guided bone regeneration at the time of implant placement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-9dsnjq8	Effect of Strengthening Exercises on the force transmission between the latissimus dorsi and the gluteus maximos	Not yet recruiting	Intervention	2022-12-07	<NULL>	<NULL>	5759	Evaluation of the effect of Resistance Training on myofascial force transmission between latissimus dorsi and gluteus maximus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9dsnjq8	<NULL>	Healthy volunteers; both genders; aged between 18 and 35 years; body mass index (BMI) less than or equal to 27 kg/m²; at least 25º of passive medial and lateral hip rotation without pain	Individuals who have practiced physical activity in the last three months; musculoskeletal injury or current or recent symptoms (6 months) in the assessed regions; inability to keep Latissimus Dorsi, paraspinal and hip muscles relaxed during the assessment; pain or discomfort during data collection or intervention and that makes it impossible for them to remain in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-85kg336	Pharmaceutical follow-up of patients treated in primary care	Not yet recruiting	Intervention	2022-12-09	<NULL>	<NULL>	5760	Implementation of a pharmacotherapeutic service in primary care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-03	Universidade Federal de São João del-Rei (UFSJ)	Universidade Federal de São João del-Rei (UFSJ)	https://ensaiosclinicos.gov.br/rg/RBR-85kg336	<NULL>	In the first phase, pharmacists who work in Primary Health Care of the Unified Health System of the participating municipalities will be included. There are no exclusion criteria at this stage. In the second phase, patients aged 18 years or older with type I Diabetes Mellitus will be included; or type II; or gestational; or adult latent autoimmune diabetes, known as the LADA type; or Maturity Onset Diabetes of the Young MODY; and who are using at least one drug for the treatment of Diabetes Mellitus	Second phase: patients who are not responsible for their own pharmacotherapy and who do not have a caregiver to accompany them to consultations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-4r6jhy6	Conservative versus surgical treatment of grade III acromioclavicular dislocations	Not yet recruiting	Intervention	2022-12-13	<NULL>	<NULL>	5761	Conservative versus surgical treatment of grade III acromioclavicular dislocations: prospective and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-15	Centro de Traumatologia do Esporte da Escola Paulista de Medicina	Centro de Traumatologia do Esporte da Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-4r6jhy6	<NULL>	Both genders; over 18 years of age; type III acromioclavicular dislocations with up to 21 days of evolution; absence of acromioclavicular dislocation in the shoulder in question; absence of previous surgery on the shoulder in question; absence of concomitant fracture of the acromion, coracoid or clavicle; signing the consent form.	Patients who did not meet the return schedule; patients in whom radiological examinations were not performed correctly; patients who did not comply with the proposed rehabilitation program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-7w6dh9q	Effect of a simulated environment on the knowledge and skills of health course students	Not yet recruiting	Intervention	2022-12-15	<NULL>	<NULL>	5765	Effectiveness of a simulated environment on the knowledge and skills of healthcare students	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Juiz de Fora	Faculdade de Enfermagem da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7w6dh9q	<NULL>	Students aged 18 or over. Students who have already taken the Fundamentals and Technologies of Nursing Care	Students who are not attending the course. Students who drop out. Students who do not fully participate in the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-2fqcbrx	A  study to evaluate the efficacy of Eclipta prostrata (L.) L. in the treatment of atopic dermatitis in children	Not yet recruiting	Intervention	2022-12-16	<NULL>	<NULL>	5766	A double-blind, randomized, placebo-controlled study to evaluate the efficacy of Eclipta prostrata (L.) L. in the treatment of atopic dermatitis in children above 2 years old	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - USP	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FAEPA)	https://ensaiosclinicos.gov.br/rg/RBR-2fqcbrx	<NULL>	Children and adolescents between 2 and 18 years old; clinical diagnosis of atopic dermatitis, according to the Hanifin and Rajka criteria	Diagnosis or presence of acute or chronic cutaneous diseases, not suggestive of atopic dermatitis, that may interfere with the study results; use of corticosteroids, systemic immunosuppressants or immunobiologicals for at least 30 days before or during participation in the study; allergy or serious adverse events attributable to the administration of the investigational product; non-adherence to treatment (ie, not using the investigational product regularly, as prescribed) for at least one continuous month; failure to attend more than 50% of the evaluations (clinical and/or laboratory) that will be carried out during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-106gykpj	The Effect of Hypopressive training improves Postpartum Belly, urine Loss and Abdominal Strength	Not yet recruiting	Intervention	2022-12-22	<NULL>	<NULL>	5774	The Effect of Hypopressive Exercises, original method, on improving Rectus Abdominal Diastasis, Adbominal Dysfunction and Pevic Floor Complaints in postpartum women: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-106gykpj	<NULL>	Will be included women aged 18 or over;  between 45 days and six months postpartum; with diagnosis of diastasis, considered as from 2 cm of distance at a point of the extension of the linea alba,  no history of previous abdominal aesthetic surgeries; do not have musculoskeletal disease that makes it impossible to perform the requested exercises.	Women who miss 20% of the intervention or do not show up for evaluation; women diagnosed with midline abdominal hernia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-8dvw5zp	Intervenções Farmacêuticas sobre o tratamento medicamentoso dos idosos com Doença de Risco Cardiovascular	Not yet recruiting	Intervention	2022-12-22	<NULL>	<NULL>	5775	Pharmaceutical Interventions on the Complexity of Pharmacotherapy in the elderly with Cardiovascular Risk Disease: a randomized controlled clinical trial with a pharmacoeconomic study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8dvw5zp	<NULL>	Be aged 60 years or older; Perform outpatient follow-up by physicians from the study site; Having systemic arterial hypertension, diabetes mellitus and/or dyslipidemia; Having uncontrolled blood pressure, glycemic and/or lipid levels; Taking medication for a period equal to or greater than three months for one of the chronic conditions of the study, these drugs being: losartan potassium together or not with other medications (systemic arterial hypertension), metformin together or not with other medications (diabetes mellitus), simvastatin together or not with other drugs (dyslipidemia); Included patients or caregivers must sign the Free and Informed Consent Form (TCLE)	Patients diagnosed with resistant or secondary systemic arterial hypertension; History of myocardial infarction or stroke in the last six months; Diabetes and/or secondary dyslipidemia; End-stage renal disease (glomerular filtration rate &lt;10mL/min or hemodialysis); Liver disease; Cancer treatment; Acquired immunodeficiency syndrome or anticoagulation; Unstable psychiatric illness; If the patient is already followed up by other clinical pharmacists; Inability to attend scheduled appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-5vw3vpg	Study comparing vaginal energy equipment	Not yet recruiting	Intervention	2022-12-26	<NULL>	<NULL>	5777	Laser and Radiofrequency treatment in women with Genitourinary Menopause Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-5vw3vpg	<NULL>	Post-menopausal women; genitourinary menopausal syndrome symptoms; vaginal dryness complaint	Vaginal estrogen use in the last 6 months; current or past 6 months use of systemic hormone replacement therapy; presence of stage III or IV pelvic organ prolapses; use of pacemaker; decompensated heart disease; cognitive deficit; peripheral or central neurological disorders; presence of any type of cancer or cervical dysplasia; hx of active urinary or vaginal infection; decompensated metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-5tw3rrr	The effects of Osteopathic Treatment with specific techniques in patients with chronic non-specific back pain	Not yet recruiting	Intervention	2022-12-27	<NULL>	<NULL>	5780	The effects of specific Osteopathic Manipulative Treatment in patients with non-specific Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-26	Silvia de Lima Filó Lins	Clinica Reabilitar	https://ensaiosclinicos.gov.br/rg/RBR-5tw3rrr	<NULL>	Both sexes. Adults from 18 to 65 years old. Chronic non-specific low back pain for more than 3 months. With or without irradiation to the lower limb. Numerical rating scale of the same or greater than 2 in the last week. Score not greater than Roland Morris disability equal to 4.	Spinal canal stenosis, spine surgery or hip arthroplasty, recent trauma or fracture; infection, active cancer; reporting unexplained weight loss in the last month; pregnancy, breastfeeding or expecting to become pregnant in the next 3 months; neurological disorders such as cauda equina syndrome, spinal cord injury, alzheimer&apos;s, amyotrophic lateral sclerosis, multiple sclerosis, parkinson&apos;s, stroke; cardiorespiratory disorders, congestive heart failure, heart attack within the last 24 months, or any bleeding disorder; musculoskeletal disorders such as advanced osteoporosis, rheumatoid arthritis, avascular necrosis or osteonecrosis, osteoarthritis, use of narcotics or muscle relaxants during study enrollment, report having received any manual therapy intervention applied to the spine 30 days prior to the first study intervention, have a body mass index &gt; 35 kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-7fqxkpp	Effects of an Application on the Knowledge of nursing students interventions	Not yet recruiting	Intervention	2022-12-28	<NULL>	<NULL>	5782	The effectiveness of using a Mobile Application in the knowledge of nursing students about the Health of the Elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Faculdade de Ceilândia da Universidade de Brasília	Fundação Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7fqxkpp	<NULL>	Being a student regularly enrolled in the nursing course; being in the 9th or 10th-degree semester; having a cell phone with internet to access the app; showing availability to participate in the research; being available to participate in the meetings.	Students who have any impediment (personal, emotional, and others) the use of the app; do not have a mobile device with the Android or IOS operating system; express unfamiliarity with digital technology; tahose who did not complete the research stages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-4mzcwpw	The extra benefit of using topical Clobetasol before Hydroquinone 4% in the treatment of Melasma	Not yet recruiting	Intervention	2022-12-28	<NULL>	<NULL>	5784	Topical Clobetasol as an adjunct treatment to 4% Hydroquinone in moderate to severe facial Melasma: a randomized, double-blind, controlled clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Estadual Paulista (UNESP)	Universidade Estadual Paulista (UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-4mzcwpw	<NULL>	Women; age between 18 and 60 years old; with moderate to severe facial melasma or mMasi greater than 5; without treatment for at least 45 days except of the using of sunscreen	Pregnant and lactating women; carriers of other concomitant facial dermatoses; dermatoses with photosensitivity; glaucoma; previous episode of perioral dermatitis; melasma with mMASI less than 5; history of hypersensitivity or local adverse reactions to the use of hydroquinone or clobetasol or any other component of the formulation described	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-4d8jr7s	Health Technology Tools for safe Dysphagia care: a randomized clinical trial	Not yet recruiting	Intervention	2022-12-29	<NULL>	<NULL>	5787	Health Technology Tools for safe Dysphagia care: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-17	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-4d8jr7s	<NULL>	be an adult (age ≥ 18 years and &lt; 60 years);present risk of dysphagia verified when meeting two or more criteria according to Felix et al (2017) and later confirmed by swallowing videoendoscopy (VED);those who confirm voluntary participation in the study by signing the Free and Informed Consent Term (FICT).	Participants who have an intellectual condition that makes it impossible for them to participate and/or understand the stages of the research; Participants diagnosed with severe dysphagia after VED will also be excluded considering the risk of maintaining oral feeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-8xdc8yz	Use of Olaparib, a drug that inhibits an enzyme linked to inflammatory response and DNA repair, in sepsis	Not yet recruiting	Intervention	2022-12-30	<NULL>	<NULL>	5790	Randomized clinical trial to evaluate the safety and pharmacodynamics of the PARP inhibitor Olaparib in sepsis	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2023-02-01	Escola Paulista de Medicina, Universidade Federal de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xdc8yz	<NULL>	Male patients diagnosed with septic shock for less than 24 hours; signing of free and informed consent form	Female patients (women) because women&apos;s hormones can alter the effects of olaparib; patients unable to use medication by mouth or by tube; patients with AIDS; patients using immunosuppressive therapy, that is, which compromises the body&apos;s defenses; patients using corticosteroids; patients with cancer or undergoing chemotherapy; chemotherapy performed up to 30 days; patients who had cardiac arrest; patients with recent acute infarction or problems with the coronary artery, the artery that supplies the heart; liver disease, such as liver cirrhosis; very severe patients, with the prospect of death within 24 hours; palliative or end-of-life care; patients using treatments that may have their effects altered or alter the effects of olaparib (examples: itraconazole, fluconazole, verapamil, rifampicin, phenytoin, carbamazepine, phenobarbital and modafinil; Saint John&apos;s herb)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-6v5cvhj	Family constellation and chronic pelvic pain	Not yet recruiting	Intervention	2023-01-02	<NULL>	<NULL>	5796	The effect of Family constellation on quality of life, anxiety, depression, resilience and pain intensity in women with chronic pelvic pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-23	Hospital das Clínicas da Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6v5cvhj	<NULL>	Age ≥ 18 years; women with lower abdominal pain starting at least six months ago, not exclusively cyclical or related to intercourse	History of pregnancy in the last 12 months; suspected or confirmed current pregnancy; history of treatment for malignant neoplasm, with the exception of non-melanoma skin cancer; history of surgery in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-97vs4tt	Effect of Exercises with Partial Blood Flow Restriction on muscular and functional aspects of individuals with difference in muscle strength between lower limbs	Not yet recruiting	Intervention	2023-01-09	<NULL>	<NULL>	5806	Effects of Partial Vascular Occlusion on muscular and functional aspects of individuals with Strength Asymmetry in Lower Limbs	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-97vs4tt	<NULL>	Participants must be between 18 and 59 years old; presence of muscle imbalance, identified by a difference greater than or equal to 10% in muscle strength between the lower limbs and/or presenting values within the upper quartile among all those evaluated, if difference greater than or equal to 5% and medical clearance to perform the test training, provided by the physician associated with the study (Dr. Francisco Wekerlin Morozowski)	Participants will be excluded from the research if they present alterations that make it impossible to complete the questionnaires or understand the guidelines and carry out the tests; systolic blood pressure greater than or equal to 140 mmHg or diastolic blood pressure greater than or equal to 90 mmHg; cannot have more than one risk factor for thromboembolism, which includes: (1) body mass index greater than or equal to 30 kg.m-2; (2) diagnosis of chronic inflammatory disease; (3) history of pelvic, hip, and femur fractures; (4) major surgeries in the last 6 months; (5) diagnosis of varicose veins in the last 6 months; (6) family history of deep vein thrombosis and pulmonary embolism; (7) use of oral contraceptive methods; or (8) tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-97vy9n7	The effects of Home Rehabilitation compared to Face-to-face Rehabilitation in people with Peripheral Arterial Disease	Not yet recruiting	Intervention	2022-04-14	<NULL>	<NULL>	5813	Effectiveness of Home-based Rehabilitation compared to Face-to-face Rehabilitation in individuals with Peripheral Arterial Disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais  (HC-UFMG)	https://ensaiosclinicos.gov.br/rg/RBR-97vy9n7	<NULL>	Individuals over 18 years of age and with a diagnosis of peripheral arterial disease confirmed by the service; who have an ankle-brachial index at rest below 0.90; complain of intermittent claudication; no pain at rest; clinical stability no decompensation or hospitalization in the last three months; and who have access to a telephone	Will not be eligible subjects whose gait is limited by a condition other than peripheral arterial disease  (such as orthopedic; neurological or respiratory problems); who have any medical condition in which exercise is contraindicated (e.g. sepsis; critical limb ischemia; unstable angina; severe heart failure; active malignancy); and/or those who, in the concomitant presence of coronary artery disease are considered to be at high risk for moderate-intensity physical exercise; and/or have cognitive impairment assessed using the Mini-State Examination Mental in individuals aged equal or older to 60 years through the cut-off point of 13 for illiterates, 18 for low and medium schooling and 26 for high schooling; and/or are unable to understand and perform the procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-6dctww5	Movement research project: effects on movement after Physical Therapy in children with Cerebral Palsy after application of Botulinum Toxin type A	Not yet recruiting	Intervention	2023-01-12	<NULL>	<NULL>	5816	Kinesis research project: effects on motor performance after Physiotherapy Care in children with Cerebral Palsy after application of Botulinum Toxin type A	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-30	Hospital Universitário Bettina Ferro de Souza	Hospital Universitário Bettina Ferro de Souza	https://ensaiosclinicos.gov.br/rg/RBR-6dctww5	<NULL>	Affected with diparetic or spastic hemiparetic cerebral palsy; age between 4 and 14 years; both genders; be able to walk independently in a closed environment (Gross Motor Function Classification System [GMFCS] from I to III; able to perform all assessment and treatment procedures in the study	Presence of joint blockage in the joints of the lower limbs; previous orthopedic surgery in the lower limbs up to one year prior to selection; presence of visual impairment; important cognitive alterations that prevent the accomplishment of the study protocols; abandonment of physical therapy; presence of fixed contracture in the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-9xtq9p6	CuidAR: reducing hospitalizations and costs with Asthma in Brazil	Not yet recruiting	Intervention	2023-01-16	<NULL>	<NULL>	5827	CuidAR: reducing morbidity and costs in Asthma in the country	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Associação Hospitalar Moinhos de Vento	Associação Hospitalar Moinhos de Vento	https://ensaiosclinicos.gov.br/rg/RBR-9xtq9p6	<NULL>	Participants of both sexes, aged between ≥6 and ≤65 years at the time of study entry; Medical diagnosis of asthma; Asthma Control Test or Childhood Asthma Control Test with a score &lt; 20; Previous history of two or more episodes of exacerbation; use of bronchodilators and systemic corticosteroids in the last 12 months; Possibility of access by the study team through the patient&apos;s personal phone and/or guardians; Patient followed up for at least 3 months in the basic health unit.	Absence of consent to participate in the study by the guardian and/or participant; Patients diagnosed with chronic obstructive pulmonary disease, defined as dyspnea accompanied by chronic cough with or without sputum, recurrent respiratory infections and spirometry with an forced expiratory volume in one second/forced vital capacity index &lt;0.7 after bronchodilator administration; Major smoking history (&gt; 20 years of smoking or &gt; 10 packs/year); Pregnant women, breastfeeding and/or planned pregnancy during the study period; Hospitalization for asthma in the last 30 days; Cognitive impairment and other conditions that may affect asthma treatment or study adherence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-57c9wnd	Prebiotic and functional effects of Ora-pro-nobis (Pereskia aculleata) in overweight women	Not yet recruiting	Intervention	2023-01-17	<NULL>	<NULL>	5830	Effects of Ora-pro-nobis (Pereskia aculleata) on female health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Universidade Vila Velha	Universidade Vila Velha	https://ensaiosclinicos.gov.br/rg/RBR-57c9wnd	<NULL>	Volunteer women; age between 18-59 years; diagnosed with overweight or obesity by BMI&gt;24.5;	Disease diagnosis; consumption of food supplements in the last 6 months; consumption of laxatives in the last 6 months; consumption of antibiotics in the last 6 months; surgical procedures in the last 6 months; vegetarianism; consumption of herbal remedies; consumption of herbal preparations; known allergic reactions to product components; intake of probiotics in the previous year; use of hypoglycemic drugs; use of lipid-lowering drugs; use of hypotensive; presence of other comorbidities; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2ntr3yd	Evaluation of vaginal atrophy symptoms and sexual function in Breast Cancer Survivors after local treatment with Radiofrequency	Not yet recruiting	Intervention	2023-01-24	<NULL>	<NULL>	5841	Evaluation of vaginal microbiota and sexual function after Microablative Fractional Radiofrequency for the Genitourinary Syndrome of Menopause in Breast Cancer suvivors	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2ntr3yd	<NULL>	Women with nonmetastatic breast cancer; age 45 to 65 years; sexually active; with genitourinary symptoms	Women with recurrent or metastatic cancer; prior reconstructive pelvic surgery for prolapse; use any form of hormonal therapy in the last six months; use of lubricants or moisturizers in the past month; the presence of genital infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-59q849	Gynecological perceived efficacy of HB22	Not yet recruiting	Intervention	2020-05-21	<NULL>	<NULL>	5854	Clinical assessment of gynecological acceptability and subjective perceived efficacy under Normal conditions of use for Vaginal Moisture Restorative Moisturizer HB22	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-30	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-59q849	<NULL>	Female participants; Participants complaining of vaginal dryness and active sex life; Age between 18 to 65 years; Examination of gynecological inspection must be normal; Agreement to obey the trial procedures and attend the clinic on the days and times determined for medical evaluations; Understand, consent and sign the Free and Informed Consent Form (ICF).	Pregnancy or pregnancy risk; Lactation; Use of anti-inflammatory / immunosuppressive drugs (in the last 30 days and during the study); Active skin pathologies (local and / or disseminated) in the evaluation area; Pathologies that cause suppression of immunity, such as diabetes, HIV, etc .; Endocrine pathologies such as thyroid diseases, ovarian or adrenal gland disorders; Any infection in the product analysis region diagnosed at the time of inclusion; Other conditions considered by the investigating physician as reasonable for the individual&apos;s disqualification from participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-9tf7y5	Gynecological assessment of HG22	Not yet recruiting	Intervention	2020-06-03	<NULL>	<NULL>	5865	Clinical assessment of gynecological acceptability and subjective perceived efficacy under normal conditions of use for vaginal moisture restorative moisturizer HG22	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-15	INFAN - Indústria Química e Farmacêutica Nacional	INFAN - Indústria Química e Farmacêutica Nacional	https://ensaiosclinicos.gov.br/rg/RBR-9tf7y5	<NULL>	Female participants; Participants complaining of vaginal dryness and active sex life; Age between 18 to 65 years; Examination of gynecological inspection must be normal; Agreement to obey the trial procedures and attend the clinic on the days and times determined for medical evaluations; Understand, consent and sign the Free and Informed Consent Form (ICF).	Pregnancy or pregnancy risk; Lactation; Use of anti-inflammatory / immunosuppressive drugs (in the last 30 days and during the study); Active skin pathologies (local and / or disseminated) in the evaluation area; Pathologies that cause suppression of immunity, such as diabetes, HIV, etc .; Endocrine pathologies such as thyroid diseases, ovarian or adrenal gland disorders; Any infection in the product analysis region diagnosed at the time of inclusion; Other conditions considered by the investigating physician as reasonable for the individual&apos;s disqualification from participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-6f2q3my	Assessment of acceptance in use and self-assessment under normal use conditions	Not yet recruiting	Intervention	2023-02-05	<NULL>	<NULL>	5866	Assessment of acceptance in use and self-assessment by the pediatric subject of the study (100222-01), under normal use conditions	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-31	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-6f2q3my	<NULL>	Healthy pediatric subjects; Intact skin on test site; Agreement of the pediatric subject&apos;s legal guardian to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; Ability by the guardian of consenting to the participation of the pediatric subject in the study; Aged between 2 and 12 years old; Study subjects of any gender; Subjects presenting phototype (Fitzpatrick) I to IV; Users of products of the same category	Skin pathology on the area of product application;Diabetes; Immunological insufficiency; Current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs; Skin diseases: vitiligo, psoriasis, atopic dermatitis; History of reaction to the category of product tested; Other diseases or medications that might directly interfere with the study or put subject&apos;s health under risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-5753p8c	Assessment of acceptance and self-assessment of a nasal spray	Not yet recruiting	Intervention	2023-02-05	<NULL>	<NULL>	5867	Assessment of acceptance in use and self-assessment of a nasal spray (094840-01) under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-31	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5753p8c	<NULL>	Healthy pediatric subjects; Intact skin on test site; Agreement of the child&apos;s legal guardian to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; Ability by the guardian of consenting to the participation of the child in the study; Children aged from 6 months to 2 years and 11 months; Study subjects of any gender. Subjects presenting phototype (Fitzpatrick) I to IV;Users of products of the same category.	Skin pathology on the area of product application; Diabetes; Immunological insufficiency.Current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs.Skin diseases: vitiligo, psoriasis, atopic dermatitis; History of reaction to the category of product tested; Other diseases or medications that might directly interfere with the study or put subject&apos;s health under risk.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-10v7xxmp	Effect of Visceral Osteopathy on heart rate and pain in patients with Fibromyalgia	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5868	Effect of Visceral Osteopathic Manipulative Therapy on heart rate variability and conditional pain modulation in patients with Fibromyalgia - controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Escola de Osteopatia de Madrid	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-10v7xxmp	<NULL>	Female participants;aged between 18 and 65 years; clinical diagnosis of fibromyalgia; persistent or recurrent musculoskeletal pain greater than 12 weeks; symptomatic at the time; motor independence; good understanding of the Portuguese language to answer the questionnaires	Hstory of recent trauma or fractures; tumors or a history of cancer; rheumatologic disease in an acute inflammatory phase; heart disease; use of a pacemaker; pregnant or postpartum women who are breastfeeding during the evaluation or treatment period; cognitive limitations to complete the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-10yxgcr9	Effect of physical exercise performed at home on people with the indeterminate form of Chagas disease	Not yet recruiting	Intervention	2021-01-12	<NULL>	<NULL>	5873	Home-based physical exercise program in the indeterminate form of Chagas Disease (PEDI-CHAGAS STUDY): A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	Instituto Nacional de Infectologia Evandro Chagas - Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10yxgcr9	<NULL>	Serological positivity for Chagas disease; both sexes; absence of symptoms and or clinical signs of cardiac and / or digestive disorders associated with Chagas disease.	Age below 18 years; cardiopathies of non-chagasic etiology; osteomioarticular changes that make it impossible to perform the physical exercise protocol; clinical contraindication for physical exercise; regular physical exercise in the last 2 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-4ycx6xp	The Effect of Physical Exercise Performed During Hemodialysis on Blood Pressure, Heart Rate, Oxygenation, Muscle Strength, Fragility and Fatigue of People with Chronic Kidney Disease	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5874	Effectiveness of Intradialytic Physical Exercise on Hemodynamic Behavior, Peripheral Muscle Strength, Fragility and Fatigue of Chronic Kidney Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-03	Universidade Cidade de São Paulo	Fundação Pública Hospital das Clínicas Gaspar Viana	https://ensaiosclinicos.gov.br/rg/RBR-4ycx6xp	<NULL>	Chronic kidney patients aged 18 years and over who undergo hemodialysis at Fundação Hospital de Clínicas Gaspar Viana-FHCGV and Monteiro Leite hemodialysis center; patients with hemodynamic stability, according to the VII Brazilian Guidelines on Arterial Hypertension and the AHA; patients with blood glucose below 250 mg/dl of blood; patients who do not have cardiac arrhythmias and cardiopulmonary limitations; patients with or without neurological and musculoskeletal sequelae, but with muscle strength above grade 3 for the muscles of the upper limbs (large dorsal, pectoralis major and biceps brachii and lower limbs (quadriceps, gluteus, iliopsoas and hamstrings)	Patients who have an arteriovenous fistula in the lower limb; patients who have any level of intellectual and/or psychological disability that may impact the performance of the activities proposed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-798j8cr	Effect of telesimulation on teaching and learning of basic in-hospital life support in nursing	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5877	Effect of telesimulation on teaching and learning of basic in-hospital life support in nursing: a quasi-experiment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-798j8cr	<NULL>	Nursing students; age equal to or greater than 18 years; having completed the discipline of Technical Bases of Nursing Assistance of the Nursing Graduation Course	Having contact with in-hospital Basic Life Support for less than 12 months; not having equipment or technological conditions to follow the intervention remotely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-5p6nv8b	The effect of grape seed flour Supplementation on decreasing weight loss and muscle mass before and after surgery in patients with colorectal cancer Cachexia.	Not yet recruiting	Intervention	2023-02-07	<NULL>	<NULL>	5879	Grape seed flour Supplementation as a strategy to reverse muscle mass loss in perioperative colorectal cancer Cachexia patients: a translational study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-16	Universidade Federal de São Paulo	Hospital Guilherme Álvaro	https://ensaiosclinicos.gov.br/rg/RBR-5p6nv8b	<NULL>	Histopathological diagnosis of colorectal carcinoma; Indication of curative surgery for resection of malignant primary colorectal tumor; Tumor classification according to the Union for Internacional Cancer Control (UICC) criteria; Pre-cachexia or cachexia diagnosis (2011 Consensus); Age between 40 and 90 years; Signed Informed Consent;	Confirmed distant metastasis; Radio/Chemotherapy treatment in the last 3 months; Body Mass Index (BMI) greater than 40 kg/m²; History of liver function impairment (Child-Pugh-Turcotte score B and C); History of chronic kidney disease (defined according KDIGO 2012); HIV positive with AIDS-related complications; Hypersensitivity to trial supplement; Continuous supplementation of polyphenols or pre/probiotics in the last 3 months; Inflammatory bowel diseases (IBD) or chronic inflammatory processes unrelated to cachexia, such as autoimmune disorders; Pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-3vj5dc5	How Much Strength Exercise does it take to Improve Insulin Sensitivity?	Not yet recruiting	Intervention	2023-02-08	<NULL>	<NULL>	5888	Acute Effects of Manipulation of Strength Exercise Volume on Insulin Sensitivity in Obese Adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-15	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-3vj5dc5	<NULL>	Individuals of both sexes with obesity (body mass index – BMI &gt; 30 kg/m²); and with central obesity (waist circumference &gt; 102 cm in men and &gt; 88 cm in women); aged over 40 years; with stable body mass (&lt;3 kg) in the last 3 months; able to perform physical activity	Individuals with signs, symptoms or presence of diabetes or any other metabolic disease, cardiovascular disease, cerebrovascular disease, kidney disease, respiratory disease, and osteoarticular disease; use of medication that affect blood glucose or insulin levels; use of anabolic steriods; use of dietary supplements that enchace physical performance (beta-alanine, sodium bicarbonate, caffeine, creatine); pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-8n2y6sq	Assessment of proctological, gynecological and dermatological acceptability using the product at home	Not yet recruiting	Intervention	2023-02-22	<NULL>	<NULL>	5916	Evaluation of the proctological , gynecological and dermatological acceptability of a health product under normal conditions of use_MAKE03.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Makelife Comercio Atacadista e Varejista LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8n2y6sq	<NULL>	Gender: female; Age: 18 to 59 years; Phototype: I to IV; Intact skin in the region; Occasional user of products in the category	"Skin marks in the experimental area that interfere with the evaluation of possible chemical reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); Pregnant or lactating women; Participants with a history of allergies to the material used in the study; History of atopy; Use of vaginal cream; Participants with a history of allergies to cosmetic products in the test category; Recent gynecological surgeries; discharges; People with immunodeficiencies; Kidney, heart or liver transplants; Active cell pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticoid in the experimental area up to 8 days before the beginning of the study. Any condition not mentioned above which, in the opinion of the investigator, may compromise the study evaluation
Note: the participants included are instructed not to change their diet, exercise routine and contraceptive method. Also, do not use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-54w3vgs	Evaluation of the proctological, gynecological and dermatological acceptability of a health product using the product at home	Not yet recruiting	Intervention	2023-02-24	<NULL>	<NULL>	5922	Evaluation of the proctological, gynecological and dermatological acceptability of a health product under normal conditions of use_MAKE02.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Makelife Comercio Atacadista e Varejista LTDA	https://ensaiosclinicos.gov.br/rg/RBR-54w3vgs	<NULL>	Women; age: 18 to 59 years old; phototype: I to IV; intact skin of the region; occasional user of category products	Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); pregnant or lactating women; participants with a history of allergy to the material used in the study; history of atopy; use of vaginal cream; participants with a history of allergy to cosmetic products in the tested category; recent gynecological surgeries; discharges; people with immunodeficiencies, kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the beginning of the study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8hmqbmf	Clinical Performance of Complete Crowns in Printed Resins obtained by Digital Flow in dentistry	Not yet recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5928	Performance of Full Crowns in Printed Resins obtained by CAD/CAM System. Clinical, controlled, triple blind and randomized study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-06	Faculdade de Odontolologia da Universidade Federal de Uberlândia	Faculdade de Odontolologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8hmqbmf	<NULL>	Adult patients aged 18 years or older; both genders; in need of a single crown in a posterior tooth(s) with major coronary destruction; that the tooth has pulp vitality or satisfactory endodontic treatment; with or without intraradicular retainer; that has a medical history that does not compromise the evolution of the results; that has the habit of brushing the teeth at least once a day; that has normal periodontal condition front to probing parameters; has occlusal stability	Patients younger than 18 years old; with some chronic disease with oral manifestations; who present some oral pathology considered serious; with signs and/or symptoms of parafunction (clenching and/or bruxism); with no oral hygiene; with periodontal disease; with allergies to any material that will be used in the study; smokers; or any other condition that may indirectly interfere with the primary and/or secondary outcomes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-9qg9qhh	Effect of oral Probiotic supplementation in children with Obesity: evaluation of the impact on body weight and variables associated with Obesity	Not yet recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5929	Effect of oral Probiotic supplementation in children with Obesity: avaluation of the impact on nutritional status and variables associated with Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-11	Fundação Universidade Federal de São João Del Rei	Secretaria municipal de saúde de Divinópolis	https://ensaiosclinicos.gov.br/rg/RBR-9qg9qhh	<NULL>	Kids; both genders; age between 7 and 10 years; with a nutritional diagnosis of obesity or severe obesity	Children with liver diseases; nephropathy; heart disease; cancer; inflammatory bowel disease using probiotic supplements; prebiotics; symbiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-7xqzb9h	Treatment for urine loss with urgent symptoms and overactive bladder with High Frequency Energy Waves	Not yet recruiting	Intervention	2023-03-03	<NULL>	<NULL>	5932	Microablative Fractional Radiofrequency versus SHAM in the treatment of women with Urinary Incontinence: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Faculdade de Ciências Médicas  da Universidade Estadual de Campinas	Faculdade de Ciências Médicas  da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7xqzb9h	<NULL>	Women aged between 45 and 65 years; with symptoms of urinary incontinence with a predominance of symptoms of urgency or overactive bladder such as increased frequency, nocturia, urinary urgency, urge incontinence, enuresis; availability to attend the treatment on the date and places previously scheduled	Pacemaker use; presence of genital prolapse stages III and IV; decompensated heart disease; cognitive deficit / difficulty in understanding; peripheral or central neurological impairment (diabetic neuropathy, nerve damage, alzheimer, parkinson); presence of any type of cancer; presence of cervical dysplasia; presence of active urinary or vaginal infection; Decompensated diabetes; mixed incontinence with a predominance of loss on exertion; Patients using estrogen vaginally in the last 6 months; Patients in current use or in the last 6 months of oral hormone replacement therapy; Patient already submitted to prolapse or sling correction surgery; Patients with neurogenic bladder; Patients who underwent drug treatment for emergency incontinence or overactive bladder less than 6 months; Patients who underwent physiotherapeutic treatment of the pelvic floor muscles or transcutaneous electrical stimulation of the tibial nerve in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8vc5r8b	Success rate of inflamed and necrotised teeth treated with the product LUM01 compared with similar products	Not yet recruiting	Intervention	2023-03-03	<NULL>	<NULL>	5933	Success rate of teeth with apical Periodontitis treated with LUM01: A randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-8vc5r8b	<NULL>	Diagnosis of necrosis with periapical lesion that will be confirmed by a negative response to pulp sensitivity tests (cold and hot tests), and radiographic evidence of periradicular bone resorption (periapical lesion); Apexes completely closed; Need for endodontic treatment; Anatomical classification in relation to curvature classes I or II (Schneider, 1971); Age between 18 and 90 years.	Patients with indication for endodontic retreatment; Images suggestive of periradicular lesions with diameters greater than 8 mm; Patients who used antibiotic therapy, immunosuppressive drugs and anti-inflammatories in the last three months; Teeth with root fractures, with previous endodontic treatment, with the presence of periodontal pockets, with anatomical complexities such as, for example, very pronounced curvatures, dystrophic calcifications, among others, with crown fracture or very extensive caries that would prevent adequate absolute isolation; Pregnant and lactating patients; Patients with systemic and oral diseases that could influence the natural course or treatment of the disease, eg AIDS, diabetes, etc; Patients with systemic conditions requiring prophylactic antibiotic coverage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-39vm2nd	Effectiveness of screening actions based on Clinical Breast Examination in Breast Cancer stage and mortality: randomized study	Not yet recruiting	Intervention	2023-03-12	<NULL>	<NULL>	5944	Effectiveness of screening actions based on systematic Clinical Breast Examination in Breast Cancer stage and mortality: randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal de Goiás	Rede Brasileira de Pesquisa em Câncer de Mama	https://ensaiosclinicos.gov.br/rg/RBR-39vm2nd	<NULL>	Participating in the study will be women aged 40 years or older; living in the city of Itaberaí (urban and rural areas); users of the Unified Health System and registered by the Family Health Strategy; who accept to participate in the project and sign the Term of Free and Informed Consent	Women under 40 years of age; with a current or suspected diagnosis of breast cancer or who refuse to collect data or sign an informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-8yvhdzj	Effects of TDCS on late muscular pain after resisted training	Not yet recruiting	Intervention	2023-03-15	<NULL>	<NULL>	5948	Effects of Transcranial Direct Current Stimulation (TDCS) on late muscular pain after resisted training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Faculdade de Ciências da Saúde do Trairí- Universidade Federal do Rio Grande do Norte (FACISA/ UFRN))	Faculdade de Ciências da Saúde do Trairí- Universidade Federal do Rio Grande do Norte (FACISA/ UFRN))	https://ensaiosclinicos.gov.br/rg/RBR-8yvhdzj	<NULL>	sedentary young adult men, recommended by the american college of sports medicine; absence of neurological or rheumatic disease known as rheumatoid arthritis, gout, lupus, and chronic chikungunya; age between 18 and 30 years; availability and interest in participating in the study and not being on analgesic and antinflammatory medication	history of seizures or epileptic illness; metallic implants in the head or neck; having exercised regularly in the last 3 months; acute inflammation of the upper respiratory tract; dental treatment within the last 4 weeks; use of nicotine, coffee or alcohol on the day of the assessment; physical activities as examples cited; walking to college, going up and down stairs, washing clothes, sweeping, up to 2 hours before the assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-2bz5dm6	Evaluation of skin Irritation and Allergy potential of a Nasal Product under controlled and maximized conditions (RIPT)	Not yet recruiting	Intervention	2023-03-22	<NULL>	<NULL>	5956	Evaluation of the potential for Primary and Cumulative Irritability and Skin Sensitization of a Nasal Spray (094840-01) under controlled and maximized conditions (RIPT)	<NULL>	1, non-randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2023-04-20	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2bz5dm6	<NULL>	Agreement to comply with safety guidelines to minimize the risks of contamination with COVID-19; healthy participants; both genders; intact skin in the test region; agreement to adhere to trial procedures, scheduled visits, and requirements; ability to consent to your participation in the study in writing; age 18 to 70 years; phototype (Fitzpatrick) I to IV	Participants who belong to the risk group for COVID-19 (diabetes, with chronic cardiovascular, kidney and respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group); pregnant or lactating women; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); active dermatoses (local or disseminated) that may interfere with the study results; history of allergic reactions, irritation or intense feelings of discomfort to topical cosmetics, health products or medications; history of atopy (atopic dermatitis, allergic rhinitis, allergic bronchitis, allergic conjunctivitis, etc.); discomfort with changes in temperature (too hot/too cold) and/or when using air conditioning; participants with a history of allergy to the materials used in the study; participants with known allergy to acrylates; history of pathologies aggravated or triggered by ultraviolet radiation; people with immunodeficiencies; intense sun exposure or tanning session up to 15 days before the initial assessment; prediction of intense sun exposure or tanning session during the study period; planning to take a bath in the sea, pool or bathtub during the study; participants who practice water sports; dermographism; body aesthetic and/or dermatological treatment up to 03 weeks before selection; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs and corticosteroids up to 2 weeks before selection or, considering deposit corticosteroids, the interval should be 1 month before selection; treatment with acidic vitamin A and/or its derivatives orally or topically up to 01 month before the beginning of the study; prediction of vaccination during the study or up to 03 weeks before the study; be participating or have participated in another clinical study that ended less than 07 days before the selection, in case the previous study was acceptable in use; be participating or have participated in another clinical study that ended less than 21 days ago, if the previous study is a compatibility or investigative study of Adverse Reaction; any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; history of non-adherence or unwillingness to adhere to the study protocol; professionals directly involved in carrying out this protocol and their family members	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-6h5knrj	Virtual rehabilitation in patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5957	Telerrehabilitation in individuals with Parkinson&apos;s disease: Single-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Neurobots Pesquisa e Desenvolvimento LTDA	https://ensaiosclinicos.gov.br/rg/RBR-6h5knrj	<NULL>	Individuals participating in a university extension project (AGruPar - Group therapy assistance for individuals with Parkinson&apos;s disease) will be recruited for the study, considering as eligibility criteria: Having clinical diagnosis of Parkinson&apos;s disease; Be between 20 and 70 years old; Being on regular drug treatment for PD; Being in the Parkinson&apos;s disease stage classified from 1 to 3 on the Modified Hoehn and Yahr Scale (HOEHN, YAHR, 1967), considered with mild to moderate disability (SHENKMAN et. al, 2001); Manage to walk for at least 10 meters without personal assistance	Individuals who are unable to handle the devices (computer or mobile) during remote treatment and/or who do not have a caregiver available for the appropriate purposes will be excluded; For this, before we start the evaluations will be asked if there is experience and familiarity with the management of the devices, or if there is any support for this	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-8vvpztm	Effects of strength training with Vascular Occlusion associated with Electrical Stimulation	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5958	Effects of strength training with Blood Flow Restriction associated with Neuromuscular Electrostimulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Estadual Paulista Júlio de Mesquita Filho - Instituto de Biociências	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8vvpztm	<NULL>	Will be included in the study participants of both sexes; aged between 18 and 45 years; physically active	Body Mass Index (BMI) above 30; alterations in sensibilities and mental disturbances that may alter the results or be harmful to the subject; risk factors for thromboembolism; who have a family history of deep vein thrombosis or pulmonary embolism; who have hypertension (blood pressure at rest &gt; 140/90 mmHg)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-9t36r35	Comparative study between the video laryngoscope manufactured by printer and the traditional model in Tracheal Intubation	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5959	Comparative study between the 3D-printed videolaryngoscope by lipecin (ufcspa) and the macintosh model in the management of the airways of patients undergoing Tracheal Intubation: clinical, randomized and blinded trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Irmandade da Santa Casa de Misericordia de Porto Alegre	Irmandade da Santa Casa de Misericordia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9t36r35	<NULL>	Patients of both genders; over 18 years old and under 70 years old; candidates for surgeries under general anesthesia and in need of tracheal intubation; with risk classification by the American Society of Anesthesiology	Urgent/emergency surgeries; upper airway surgeries; head and neck surgeries; orthognathic surgeries; surgeries with planned nasotracheal intubation; previous surgeries on the cervical spine; patients with a body mass index greater than 35; patients with cervical disc injury; with spine fractures; patients using a cervical collar; patients with head and neck injuries that preclude the use of standard intubation techniques; patients with type I diabetes; syndromic patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-5xnhwsw	The effectiveness of Auricular Vagus Nerve Electrical Stimulation associated with Global Osteopathic Treatment in patients with Fibromyalgia	Not yet recruiting	Intervention	2022-11-30	<NULL>	<NULL>	5965	Effect of Transcutaneous Electrical Stimulation of the Vagus Nerve combined with Osteopathic Global Treatment in women with Fibromyalgia: clinical trial randomized controlled	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-03	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5xnhwsw	<NULL>	Female volunteers; residents of greater Florianópolis; clinical diagnosis of Fibromyalgia; over 18 years of age and must sign the Free and Informed Consent Form	Volunteers with cardiovascular diseases; pulmonary; kidneys; oncological; pacemaker; epilepsy; skin pathologies; infection; decompensated metabolic diseases; decompensated arterial hypertension; aquaphobia; joint prostheses that make the technique unfeasible with global osteopathic treatment; associated rheumatologic diseases; cognitive not preserved; musculoskeletal disorders that compromise the execution of the proposed interventions; immunosuppressed; pregnant or lactating women; skin irritation from electrical stimulation; piercing in the area of the concha cava and cymba of the ear where the electrostimulation will be performed; have urinary incontinence; fecal incontinence; decreased skin sensitivity and vestibular dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-10d7dj3w	Evaluation of the dermatological acceptability of a health product using the product at home	Not yet recruiting	Intervention	2023-03-28	<NULL>	<NULL>	5966	Dermatological clinical acceptability study under normal conditions of use with cosmetic appreciability (evaluation of the opinion of volunteers) of a health product under normal conditions of use_Ave04.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-25	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Avenca Indústria Cosmética Eireli -EPP	https://ensaiosclinicos.gov.br/rg/RBR-10d7dj3w	<NULL>	Intact skin in the product application region (intimate region); Age 18 to 65 years; Women; Participants with phototypes I, II, III and IV (according to the Fitzpatrick classification); No history of irritation/allergy to the material used in the study; Having signed the Free and Informed Consent Form (TCLE); Participants who want to participate in the study without financial profit	Participants who have or have had symptoms characteristic of COVID-19 for at least 7 days prior to the survey date; Participants who are part of the COVID-19 risk group (elderly people, people with heart and lung diseases, people with immunodeficiencies, people undergoing transplants or undergoing chemotherapy; people with kidney diseases or on dialysis; diabetics, people with liver diseases and obese people) ; participants who refuse to participate in the study in question; Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); Active dermatoses (local and disseminated) that may interfere with the study results; History of dermatological pathologies in the study region; History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medications; Participants with a history of allergy to the material used in the study; Intense sun exposure or tanning session up to 15 days before the initial assessment; Prediction of intense sun exposure or tanning session, during the study period; Provision of bathing in the sea, swimming pool or sauna during the study; Participants who practice water sports; Use of the following topical systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Treatment with acidic vitamin A and/or its derivatives orally or topically up to 01 month before the beginning of the study; Prediction of vaccination during the study or up to 03 weeks before the study, in order not to correlate the possible side effects of the vaccine with the study in question; Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; Note: the participants included are instructed not to change their diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-4h3chsp	Analysis of anti-inflammatory and anti-pain effects of Black Sesame Oil on performance of day-to-day functions and pain intensity in adults with Low Back Pain	Not yet recruiting	Intervention	2023-01-20	<NULL>	<NULL>	5971	Analysis of anti-inflammatory and antinociceptive effects of Subcritical Extract of Black Sesame (Sesamum Indicum L.) on functional performance and pain intensity in adults with Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal do Oeste do Pará	Universidade Federal do Oeste do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4h3chsp	<NULL>	Adults of both sexes; be in the age group between 18 and 55 years; peoples confirmed with the presence of low back pain; present functional impairment and limiting pain due to low back pain; staying one day prior to the start of the study intervention without performing any type of treatment for low back pain; have consent, voluntarily, through the Free and Informed Consent Term (ICF)	"Presence of neoplastic, infectious, neurological, severe progressive orthopedic, rheumatic 
or autoimmune conditions; fibromyalgia diagnosis; presence of decompensated metabolic and/or cardiorespiratory disorders; pregnancy status; obesity; compression fracture of the spine; candidates for neurosurgery or orthopedic surgery; use of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, analgesics, muscle relaxants, psychotropic drugs and/or some other specific treatment for low back pain during the study intervention; previous surgery on the lumbar spine; to present changes in cognitive functions that make it impossible to proceed with the study treatment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-9778pj4	Mobile app to assist in the treatment of Adolescent Idiopathic Scoliosis	Not yet recruiting	Intervention	2023-03-29	<NULL>	<NULL>	5973	Development and validation of a tool for education and assistance in the conservative treatment of Adolescent Idiopathic Scoliosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9778pj4	<NULL>	Female adolescents; age between 10 and 17 years old; diagnosis of adolescent idiopathic scoliosis for at least three months; in conservative treatment with the use of a brace and specific physiotherapeutic exercises for scoliosis; literate, who are attending school regularly; have a smartphone with internet access	Scoliosis with possible non-idiopathic etiology; diagnosis of neurological, neuromuscular pathologies or congenital malformation; other health problems that make physical activity impossible; cognition and learning problems; inability to understand Portuguese; surgery for scoliosis scheduled for the next six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-5zdnw6t	An online-based Nutritional Intervention study to promote a healthy diet among Amazonian schoolchildren (Cruzeiro do Sul/Acre-Brazil)	Not yet recruiting	Intervention	2023-03-30	<NULL>	<NULL>	5976	Remote Nutritional intervention to promote healthy eating practices among Amazonian schoolchildren: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Faculdade de Saúde Pública da Universidade de São Paulo	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5zdnw6t	<NULL>	Being a parent or guardian of a 7- to 8-year-old schoolchild (both genders); who is a participant in the Maternal-Infant Birth Cohort Study in Acre; be literate; and have access to a cell phone with internet access	Não ter acesso semanal à internet; não ter disponibilidade para acompanhar o estudo durante as 24 semanas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-5dym7yh	Monitoring Band for Encephalic Involvement in Liver Diseases	Not yet recruiting	Observational	2023-04-05	<NULL>	<NULL>	5984	Non-invasive method for Monitoring Intracranial Pressure in the evaluation of Hepatic Encephalopathy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-20	Faculdade de Medicina de São José do Rio Preto - Famerp - SP	Brain4Care	https://ensaiosclinicos.gov.br/rg/RBR-5dym7yh	<NULL>	Subjects with acute liver disease; subjects with chronic liver disease; subjects with exacerbation of chronic liver disease	Refusal by the subjects or their guardians to participate in the study; subjects with healthy liver	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-32v2gm5	Effect of Probiotic and Sorghum Beverage on Metabolic Responses of Normal Weight and Overweight Individuals	Not yet recruiting	Intervention	2023-04-05	<NULL>	<NULL>	5985	Effect of Probiotic (Lactobacillus rhamnosus) and Symbiotic Beverage with Extruded and Germinated Sorghum ([Sorghum bicolor (L.) moench]) on Metabolic Responses of Adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-32v2gm5	<NULL>	fasting capillary blood glucose ranging from 70 to 99 mg/dL; regular breakfast intake; Body Mass Index (BMI) between 27 and 34.9 kg/m²; body fat percentage &gt; 30% for females and &gt; 20% for males; increased waist circumference; have a level of light physical activity; level of food restriction/disinhibition ≤ 14	smokers; alcohol consumption greater than 2 doses/day (&gt; 50g of ethanol/day); use of medications that affect blood glucose, energy metabolism or appetite; use of medications, herbs, or diets to reduce appetite and body weight; weight instability (gain or loss of more or less 3 kg in the 3 months prior to the beginning of the study); recent change in physical activity level; aversion, intolerance or allergy to food provided in the study; existence or history of recent digestive, liver, kidney, cardiovascular, thyroid or inflammatory diseases, diagnosis of cancer in the previous year; report of eating disorders; pregnant or lactating; use of laxatives or antibiotics in the three months prior to the beginning of the study; continuous use of anti-inflammatory drugs and/or corticosteroids; use of probiotics, prebiotics or synbiotics (&gt; 2 times a week) in the month prior to the beginning of the study; menstrual irregularity three months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-9hyfc4v	Electrical Stimulation and the potential therapeutic approach in different populations	Not yet recruiting	Intervention	2022-11-22	<NULL>	<NULL>	5987	Transcranial Direct Current Stimulation and the potential therapeutic approach in different populations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Ciências da Saúde do Trairí	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-9hyfc4v	<NULL>	Participants were selected from a specialized outpatient service and regarded as suitable to participate in this study if they fulfilled the following criteria: clinical diagnoses of diabetic polyneuropathy; aged from 30 to 69 years; not lactating; no history of brain surgery, tumor, or intracranial metal implantation	Participants with any uncontrolled clinical disease, such as thyroid disease, cardiovascular, pulmonary, haematological or renal disease; alcohol or other substance abuse; pregnancy; lactation; neuropsychiatric disorders; history of epilepsy and metallic implants in the head were excluded; patients with significant cognitive dysfunction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-49p6g3t	Evaluation of pelvic floor muscle function after clinical surgery or surgery associated with cystopexy to control urinary loss	Not yet recruiting	Intervention	2023-04-10	<NULL>	<NULL>	5989	Evaluation of the functionality of the pelvic floor muscles after Urinary Incontinence Surgeries isolated and associated with Cystopexy: a cohort study and clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-49p6g3t	<NULL>	Age between 18 and 65 years; no historic of surgery for urinary incontinence and correction of anterior prolapse; no historic of hysterectomy;	No psychic disorders; neoplasms; the presence of alterations in the organs that present posterior pelvic; decide not to continue the research; withdraw consent;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-9p3w4hb	Bleeding Control after Tooth Removal in a patient using anticoagulant medication	Not yet recruiting	Intervention	2023-04-13	<NULL>	<NULL>	6001	Use of Hemostatics in alveolar socket after Dental Extraction in anticoagulated individuals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-15	Universidade de Cuiabá	Hospital Geral e Maternidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-9p3w4hb	<NULL>	Volunteers using anticoagulant therapy continuously; with Surgical indication for tooth extraction; with international normalized ratio (INR) values reported by prothrombin time of up to 3.5; who agree to participate in the research and sign the term of free and informed consent (TCLE) specific to the research in question	Volunteers with changes in preoperative laboratory tests that contraindicate dental surgery; when, for any reason, they suspend the continuous use of medication prior to surgery; individuals who do not cooperate with the postoperative instructions that interfere with the maintenance of the clot	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-4bdbbbq	Effect of a Nutritional Intervention	Not yet recruiting	Intervention	2023-04-13	<NULL>	<NULL>	6004	Feeding Practices: the effect of a Nutritional Intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4bdbbbq	<NULL>	66 women; age between 20 to 59 years; BMI between 25 and 39.99Kg/m2; without prior nutritional monitoring; employees linked to the University of Passo Fundo; who accept and sign the Free and Informed Consent Form	women aged less than 20 years or over 60 years; BMI less than 24.99 kg/m2 or greater than 40 kg/m2; perform nutritional monitoring; participate in other intervention protocols; use weight loss medications; pregnant and lactating women; have a non-communicable chronic disease; use medication to any Chronic Noncommunicable Disease; having had previous bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-3g6dbt8	Comparison of the results of non-surgical treatments of clavicle fractures using a sling or immobilizer in eight	Not yet recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6006	Conservative treatment of mid-shaft clavicle fractures, arm sling versus figure-of-eight immobilization. Randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-3g6dbt8	<NULL>	Volunteers with acute midshaft clavicle fractures (up to 10 days after the trauma); adults between 18 and 65 years old; no medical contraindications for the proposed treatments; acceptance and understanding of the informed consent form	Patients with proximal or distal clavicle fractures, fracture with deviation or shortening greater than 2 cm between the bone fragments in at least one of the radiographic views (AP or Zanca); pathological fracture; open fracture; associated neurovascular injury diagnosed on physical examination; head trauma (Glasgow &lt;12); fracture and/or dislocations in the ipsilateral upper limb; previous diseases in the affected limb that may influence the results; inability to maintain outpatient clinical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-55sfpf4	Physiotherapy in premature infants: from intensive care to the home environment	Not yet recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6007	Impact of a structured intervention in preterm infants from the intensive care unit to the home environment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-55sfpf4	<NULL>	50 preterm newborns (≤ 32 weeks) and their parents/main caregivers, admitted to the Neonatal Intensive Care Units will be included	Infants with congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-107zc6gt	Efficacy of Occlusal Sealants on permanent molars using two bioactive materials: a two-year follow-up clinical trial	Not yet recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6008	Efficacy of Occlusal Sealants on permanent molars using two categories of bioactive materials: a two-year follow-up double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-107zc6gt	<NULL>	Children of both sexes; age between 6 to 8 years; who will voluntarily present themselves for dental care at the Children&apos;s Dental Clinics of UEPG and at the Center for Integral Attention to Children and Adolescents (CAIC UEPG), as well as at Municipal Schools in the municipality of Ponta Grossa; with the presence of permanent molars with indication for the application of preventive sealants (ICDAS 0, but with risk of developing carious lesions) or therapeutic sealants (with the presence of incipient carious lesions ICDAS 1, 2 and 3); who are accompanied by their parents/guardians and/or with the TCLE and TALE duly signed	Children residing in rural areas and/or places where there is no supply of fluoridated water; do not show favorable behavior; are not in good general health and/or have any physical, mental, visual or hearing impairment; are allergic to any of the materials used in the research (latex); use orthodontic appliance in the period stipulated by the survey; have unfavorable oral conditions (presence of abscess, fistula, residual root, intense caries activity)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-4hbcn6z	Technique for improving the retention of composite Resin Restorations in non-carious cervical lesions	Not yet recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6011	"Evaluation of a technique for improving the retention of composite Resin Restorations in non-carious 
cervical lesions: a randomized clinical trial, split mouth, double-blinded"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-03	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4hbcn6z	<NULL>	Non-carious non-retentive cervical lesions; non-carious cervical lesions deeper than 1 mm; non-carious cervical lesions with enamel and dentin involvement; teeth without mobility.	Patients with extremely poor oral hygiene; patients with severe or chronic periodontitis; bruxist patients; patients using orthodontic devices; participants allergic to resin-based materials or any other material used in this study; pregnant women; nursing mothers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-109zf3kn	The effects of Pilates Exercises on gait, balance and risk of falls in lower limb Amputees	Not yet recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6012	Effects of a Pilates Exercise program on spatio-temporal parameters of gait, balance and risk of falls in lower limb Amputees	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-30	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-109zf3kn	<NULL>	Unilateral transtibial lower limb amputees; both genders; ages between 18 and 59 years; adapted to prosthetic use for at least 6 months; able to walk independently, without the need for auxiliary equipment; no comorbidities such as high blood pressure and diabetes; able to walk and practice exercises; without paresis or plegia of lower limbs; free from neurological diseases that could compromise verbal comprehension; no injuries to the stump that would affect the use of the prosthesis; who do not use medications that have a proven effect on balance such as antidepressants, tranquilizers or sedatives; be available to participate in the Pilates training program; not present injuries or illnesses or contraindications that prevent the performance of the evaluations and the practice of physical exercises	Lower limb amputees who are not adapted to the use of a prosthesis; who need auxiliary equipment to walk around, such as canes and crutches; hypertensive and diabetic; paresis or plegia of lower limbs; neurological diseases that compromise verbal comprehension; stump injuries; use of antidepressants, tranquilizers or sedatives; other injuries or illnesses that prevent participation in the Pilates training program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-7nbvjkh	Effects of Individualized Education on Abdominal Dialysis patients	Not yet recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6014	Impact of an Individualized Education tailored for the learning style on Peritoneal Dialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Pontificia Universidade Católica do Paraná	Baxter Healthcare	https://ensaiosclinicos.gov.br/rg/RBR-7nbvjkh	<NULL>	Age higher than 18 years old; chronic peritoneal dialysis for at least 3 months; peritoneal dialysis should be automated peritoneal dialysis; sign the informed consent	Not willing to participate in the study or don&apos;t sign the informed consent; Illiterate; blindness; be on assited peritoneal dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-83nxqwz	Standardization of breastfeeding techniques for preterm infants	Not yet recruiting	Intervention	2023-04-04	<NULL>	<NULL>	6015	Intervention for health professionals with Bundle on Translactation in an infant using the Kangaroo Method	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual do Ceará	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-83nxqwz	<NULL>	healthy babies; with clinical stability; both genders; on full enteral nutrition and a minimum weight of 1250 grams	Babies with orofacial alteration or congenital malformation; diagnoses of cardiac, gastrointestinal, pulmonary pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-9j7rs22	Anxiety and satisfaction of surgical patients	Not yet recruiting	Intervention	2023-04-18	<NULL>	<NULL>	6018	Anxiety and satisfaction of surgical patients undergoing educational intervention: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Departamento de Enfermagem da Faculdade de Medicina de Botucatu	Hospital das Clinicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-9j7rs22	<NULL>	Adult patients undergoing elective colorectal surgeries in any segment; age equal to or greater than 18 years; both gender	Patients with any kind of difficulty in verbal and written communication or comprehension; patients submitted to surgical reoperation due to complications arising from a previous surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-7wsgdm8	Minoxidil 5 mg oral versus Minoxidil 5 mg sublingual for treating Male Pattern Baldness	Not yet recruiting	Intervention	2023-04-19	<NULL>	<NULL>	6024	Minoxidil 5 mg oral versus Minoxidil 5 mg sublingual for the treatment of Male Androgenetic Alopecia: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Clinica Sanabria Transplante e Restauração Capilar	Clinica Sanabria Transplante e Restauração Capilar	https://ensaiosclinicos.gov.br/rg/RBR-7wsgdm8	<NULL>	Male patients; age between 18 and 55 years; diagnosed with Androgenetic Alopecia classified on the Norwood Hamilton scale in 3V, 4V or 5V; clarified and agreeing to participate in the research, during consultations carried out at Clínica Sanabria	Patients who underwent previous treatment for hair loss in the last 4 months; hypertensive; heart disease; kidney disease; patients with other causes of hair loss or scalp dermatoses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-10kynbky	Comparison of caloric expenditure in two types of high-intensity exercise in middle-aged individuals	Not yet recruiting	Intervention	2023-04-19	<NULL>	<NULL>	6025	Comparison of post-exercise energy expenditure and Excessive Oxygen Consumption (EPOC) in response to high-intensity interval exercise performed in a single session versus three shorter sessions over the course of a day in middle-aged subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-05	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-10kynbky	<NULL>	Healthy individuals aged 45 to 64 years; physically active.	Individuals diagnosed with cardiometabolic, renal, and pulmonary diseases; Individuals with orthopedic or neurological limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-33m2tb8	Effect of using a Nursing Care Protocol on a person with an amputation due to Diabetes Mellitus	Not yet recruiting	Intervention	2023-04-20	<NULL>	<NULL>	6029	Effect of using a Nursing Care Protocol on people with Amputations due to Diabetic Complications: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual da Paraíba - UEPB	Universidade de Pernambuco - UPE	https://ensaiosclinicos.gov.br/rg/RBR-33m2tb8	<NULL>	Be 18 years of age or older; present amputation due to diabetic complications; being treated in the inpatient units of the hospitals participating in the study	Patients admitted to the Intensive Care Unit; presenting a medical diagnosis of neurological deficit that hinders the learning process; have hearing and/or visual impairment; Health professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-6t2b47y	Hyaluronic Acid Injection for the management of shoulder Impact Syndrome	Not yet recruiting	Intervention	2023-04-25	<NULL>	<NULL>	6032	Hyaluronic Acid Injection for the management of shoulder Impact Syndrome. Triple blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-6t2b47y	<NULL>	Volunteer of both genders; presenting shoulder impingement syndrome with at least three months of symptoms without improvement with conservative treatment; older than 18 years; who have not had previous infiltrations in the evaluated shoulder; no medical contraindications to local anesthesia	Individuals with complete rotator cuff injuries or injuries greater than 50% of the tendon thickness or with traumatic cuff injuries; those submitted to previous infiltrations in the shoulder; who have a previous disease that may interfere with the result of the outcome assessment; with medical contraindication to anesthesia or any of the proposed treatments; with inability to maintain outpatient clinical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-6xbgv9j	Initial Coagulation Markers in Patients with Kala-Azar Associated with Tranexamic Acid	Not yet recruiting	Intervention	2023-04-28	<NULL>	<NULL>	6038	Early Coagulation Markers in patients with Visceral Leishmaniasis associated with Tranexamic Acid	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Instituto de Doenças Tropicais Nathan Portela - IDTNP	CIATEN - Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados	https://ensaiosclinicos.gov.br/rg/RBR-6xbgv9j	<NULL>	Patients with confirmed visceral leishmaniasis; both genders; without age restrictions, who agree to participate voluntarily by signing the Free and Informed Consent Term and the Minor&apos;s Assent Term, in patients aged between six and 18 years	Patients using anticoagulant or antiplatelet medication at the time of admission; recent diagnosis or history of thrombosis at any vascular site; congenital or acquired hemostasis disorders; need for dialysis, surgery or an invasive procedure; known or suspected hypersensitivity to any study drug; recent or past history of seizures; history of dengue fever or Severe Acute Respiratory Syndrome Coronavirus 2 infection in the last 30 days; having received specific anti-Leishmania treatment in the last 90 days; having received antifibrinolytic treatment in the last 48 hours or blood products in the last 360 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-106fywbx	Eating behavior and body image of adolescents participating in Mindfulness-based interventions	Not yet recruiting	Intervention	2023-04-29	<NULL>	<NULL>	6042	Eating behavior and body self-image of adolescents participating in Mindfulness-based interventions: a mixed methods study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-106fywbx	<NULL>	Age 15 to 19 years old	Evidence of severe depressive traits, anxiety, or stress, verified through the SCAS-BRASIL scale; Severe cognitive impairment, described through medical diagnosis; Presence of an eating disorder (anorexia, bulimia, binge eating disorder), described by medical diagnosis; Physical impairment that makes it difficult to perform the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-3hnmbdt	Dermatological test on revitalizing lotion and restorative lotion	Not yet recruiting	Intervention	2023-05-02	<NULL>	<NULL>	6045	Assessment of primary and cumulative irritation potential and sensitization potential from the skin supervised by a dermatologist to the investigational products lotion revitalizing and restorative lotion	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Kosmoscience Ciência e Tecnologia Cosm Imp Exp Ltda	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-3hnmbdt	<NULL>	Healthy research participant; age range between 18 and 70 years; both sexes; phototype (Fitzpatrick): I to IV; agree to adhere to the requirements of the study in combating the COVID-19 pandemic, through preventive measures: use a mask as recommended by the WHO; use the mask while traveling to the research center and during study procedures; maintain social distancing; frequently wash your hands with soap and/or alcohol gel and attend the research center only at scheduled times to avoid crowds; agreement not to wet the site during the entire test period; understand the test procedures and agree to adhere to the study requirements; absence of inflammatory dermatoses or tattooing at the application site; signature of the Free and Informed Consent Term (TCLE)	Gestation; lactation; participants who have hyperthermia (body temperature greater than or equal to 37.5°C); participants who have been diagnosed with COVID-19 by RT-PCR test or by the presence of IgM antibodies in the serology test, in the last 4 weeks or who are showing the following symptoms: dry or productive cough, sneezing, runny nose, body pain , headache, anosmia (loss of smell), ageusia (loss of taste) and/or any other symptom that may be related to covid-19 at the discretion of the investigator; participant who belongs to the risk group for COVID-19, that is, with chronic cardiovascular, renal and respiratory problems, immunosuppression or other conditions that the doctor judges as belonging to the risk group; participants with heart diseases (for example, but not limited to: atrial fibrillation, obstructive coronary artery disease); participants with kidney and/or neurological diseases; participants with severe or decompensated pulmonary and/or respiratory diseases; use of corticoids, antihistamines and/or anti-inflammatories; presence of localized or generalized dermatological diseases; presence of active inflammatory dermatoses in the test region; frequent exposure to the sun or tanning beds; having participated in an allergenicity study within a period of less than four weeks from the start of the study; research participants with a history of allergy to the material used in the study; history of atopy; history of pathologies aggravated or triggered by ultraviolet radiation; people with immunodeficiencies; prediction of intense sun exposure or tanning session during the study period; plan to take a bath in the sea, pool or sauna during the study; research participants who practice water sports; survey participants with dermographism; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticoids up to 2 weeks before selection; vitamin A acid treatment and/or its derivatives orally or topically up to 01 month before the beginning of the study; body aesthetic and/or dermatological treatment up to 03 weeks before selection; prediction of vaccination during the study or up to 03 weeks before the study; any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; history of non-adherence or unwillingness to adhere to the study protocol; professionals directly involved in carrying out this protocol and their families; currently participating in another study; any condition that, in the opinion of the researcher, could compromise the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-44nrnjz	Oral health literacy and behavioral factors and their association with oral conditions in preschool children	Not yet recruiting	Intervention	2023-05-03	<NULL>	<NULL>	6049	Oral health literacy and parental psychosocial factors and their association with oral conditions in preschool children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-05	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-44nrnjz	<NULL>	Volunteers over 18 years of age; who stays with the child most of the time; both sexes; who have Brazilian Portuguese as their native language; Children aged between 4 completed years and 5 years 11 months and 29 days; enrolled in the Municipal School of Early Childhood Education Tijucas do Sul	Volunteers over 80 years of age; with reported vision or hearing problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-9rydqwx	Evaluation of the effect of Ozone Therapy on the perception of pain, swelling and difficulty opening the mouth in the postoperative period of Surgery to Remove a mandibular wisdom tooth	Not yet recruiting	Intervention	2023-05-04	<NULL>	<NULL>	6051	Evaluation of the effect of Ozoniotherapy on the perception of pain, edema and post-operative trismus in Dental Extraction of third mandibular molars: a double-blind randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Livia Bonjardim Lima	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9rydqwx	<NULL>	Patients aged between 18 and 30 years. No impairment of general health as per medical history (healthy). Normal physical examination. Patients who agree to participate in the study. Patients with indication for bilateral extraction of mandibular asymptomatic third molars. Third molars in class IIB position, according to the Pell &amp; Gregory classification	History of use of any type of analgesic, anti-inflammatory and antibiotic medication in the 15 days prior to the beginning of the surgical procedure. History of hypersensitivity to drugs, substances or materials used in this experiment. Pregnancy or lactation. Pericoronitis or other local infection within 15 days prior to the surgical procedure. History of systemic disease, such as hypertension, diabetes, or diseases with high oxidative stress, such as favism, severe anemia. Shortest intervention time less than 75% of the time elapsed in the longest intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-9hk6pgz	Benefits of Physical Exercise for older adults with Obstructive Sleep Apnea	Not yet recruiting	Intervention	2023-05-04	<NULL>	<NULL>	6052	Obstructive Sleep Apnea treated with Exercise and Inspiratory Muscle Training: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9hk6pgz	<NULL>	Age between 60 and 79 years; both genders; moderate to severe Obstructive Sleep Apnea, with an apnea-hypopnea index greater than 15 events per hour; no history of previous or current Obstructive Sleep Apnea treatment; and no other sleep disturbance than Obstructive Sleep Apnea	Use sleeping medications; have engaged in physical exercise within the past six months; have contraindications (cardiovascular, respiratory, musculoskeletal, or neurological) for exercise; or have cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-10dv8yp2	Dexamethasone and Paracetamol with Codeine in Pain Control of Acute Dental Abscess: a randomized clinical trial	Not yet recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6060	Dexamethasone and Paracetamol with Codeine in Pain Control of Acute Dentoalveolar Abscess in Evolution: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10dv8yp2	<NULL>	Patients aged 18 to 55 years; diagnosis of acute dentoalveolar abscess in evolution; pain score equal to or greater than 40 mm in the Visual Analog Scale, at the time of initial care	Patients allergic to the drugs used in the present study; chronic use of opioids, steroid anti-inflammatories, antidepressants; history of liver disease; rheumatoid arthritis; severe heart disease; diagnosis of depression/anxiety; pregnant or lactating women; alcoholics; current or former users of substances such as crack, oxy, cocaine, marijuana and solvents; chronic pain; difficulties in understanding the scales	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-4ngnx3b	Nerve Stimulator implantable to ameriolate Erectile Function in men living with Spinal Cord Injury	Not yet recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6063	Safety and Tolerability of a novel implantable Nerve Stimulator to ameliorate Erectile Function: a first study in men living with Spinal Cord Injury	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	E Pizolato Preparacao de Documentos e Servicos Especializados de Apoio Administrativo	Fundação do ABC	https://ensaiosclinicos.gov.br/rg/RBR-4ngnx3b	<NULL>	Men; 18 to 55 years old; traumatic spinal cord injury; injury less than 1 year ago; treat erectile dysfunction; responsive to PDE5 inhibitors; IIEF-15 score is equal to or less than 25 points.	Spinal injury at T6 or above; history of autonomic dysreflexia; known allergies to any device material (Platinum/Iridium, Silicone, Pellethane, Titanium, Polysulfone, Polyurethane); contraindicated for surgery under general anesthesia; PSA greater than 4.0ng/mL; priapism or Peyronie&apos;s disease; hypertension; previous pelvic surgery; irradiation therapy; current use of an implantable penile device; diagnosed with a progressive degenerative neurological disease that can negatively impair erectile function; diabetes mellitus suffering from peripheral neuropathy or other complications associated with diabetes; not interested in sexual activity; currently participate in other clinical investigations; depression or abnormal behavior; IIEF-15 score equal to or greater than 26 points; high risk of prostate cancer, as determined by a positive PSA test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-7wwjrq3	Effectiveness of an early intervention program by telehealth for infants at high risk of Cerebral Palsy	Not yet recruiting	Intervention	2023-05-10	<NULL>	<NULL>	6065	Effectiveness of a goal-oriented collaborative early intervention program (early together) by telehealth for infants at high risk of Cerebral Palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7wwjrq3	<NULL>	Infants born at term or preterm aged three to five months corrected age for preterm infants and three to five months of chronological age for term infants at high risk of cerebral palsy	Children with clinical instability, tracheostomy or oxygen dependents	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-3c5f7xt	Model of attention by cell phone application to change the level of Physical Activity in workers	Not yet recruiting	Intervention	2023-05-15	<NULL>	<NULL>	6074	M-Health-mediated care model for changing the level of Physical Activity in workers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-3c5f7xt	<NULL>	Both genders. Age range above 18 years. Have an employment relationship with the Institution with a workload equal to more than 30h/week, with a face-to-face shift. Own a smartphone with Android version equal to or greater than 7.0. Have an affinity with using apps. Have internet at home (wi-fi) and/or cell phone (mobile data)	Participants who have more than one employment relationship. Participants who are undergoing chemotherapy treatment. Physically active participants and/or regular participants in a physical activity program (&gt;150 min/week)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-3xf7v9k	Effects of functional training and dual task in elderly women with and without chronic low back pain	Not yet recruiting	Intervention	2023-05-16	<NULL>	<NULL>	6082	The effects of Functional Training in asymptomatic elderly women with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3xf7v9k	<NULL>	Will be included in the research, women with a clinical diagnosis of nonspecific chronic low back pain, between 60 and 79 years old, with a complaint of low back pain for more than 3 months, a pain level greater than 3 on the numerical pain scale of 11 points and women in the same age group without low back pain and/or other type of chronic pain. Asymptomatic elderly women cannot have chronic low back pain and no episodes of pain in the last three months. Volunteers will also need to have a body mass index (BMI) &lt;30 kg/m2, not have undergone spinal surgery; not exercising regularly; not doing physical therapy or other pain treatment; not to use analgesic, anti-inflammatory, opioid or immunosuppressive medication	Exclusion criteria will be missing one of the assessments, more than 20% of the intervention or presenting any motor impairment (paraplegia, paraparesis, monoplegia, monoparesis, hemiplegia, hemiparesis), psychiatric (schizophrenia, epilepsy, severe depression) or cognitive (moderate mental retardation , severe and/or profound), auditory, visual or communication disorders that make it impossible to carry out the protocol. If there is any suspicion of a disability, the volunteer will be referred for evaluation by a general practitioner and, if confirmed, the participant will be referred to the physiotherapy, speech therapy and/or psychology departments at UFS for proper follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-58hnx64	Clinical performance of Ceramic Dental Crowns	Not yet recruiting	Intervention	2023-05-16	<NULL>	<NULL>	6083	Clinical performance of Zirconia Monolithic Implant-Supported Single Crowns: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-58hnx64	<NULL>	"Volunteers that require tooth replacement with an implant-supported single crown in one posterior quadrant in the maxilla or mandible; age from 18 to 70; good oral hygiene;	periodontal health or successful periodontal therapy; at least one adjacent tooth/restoration; presence of antagonistic contacts"	Volunteers with dental implants exhibiting biologic complications before the fabrication of the definitive implant-supported single crown; severe parafunctional habits; lack of occlusal stability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-7hh489b	Effects of exercise on strength of Colorectal Cancer patients undergoing Chemotherapy	Not yet recruiting	Intervention	2023-05-17	<NULL>	<NULL>	6086	Effects of co-contraction training on neuromuscular, biomolecular, and functional parameters in Colorectal Cancer patients undergoing Chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7hh489b	<NULL>	Men and women over the age of 18; diagnosed with colorectal cancer; undergoing chemotherapy treatment; with access to a tablet, smartphone, laptop, or computer with an integrated video camera; and willing to appear on camera during exercise sessions to enable safety monitoring	Diagnosis of cardiovascular disease and neurodegenerative diseases; presenting any other health problem that interferes with the execution of the proposed exercises and evaluations; history of neuromuscular injury in the upper and lower limbs in the last 12 months; not being considered able to participate in the study after medical evaluation; refusing to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-4hnphgb	A Mindfulness-Based Intervention to strengthen mental health and psychological resources in university students: a randomized controlled trial	Not yet recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6094	Effects of a Mindfulness-Based Intervention on the mental health of Brazilian university students: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Universidade Cesumar	Universidade Cesumar	https://ensaiosclinicos.gov.br/rg/RBR-4hnphgb	<NULL>	Undergraduate students from Cesumar University; aged ≥18 years;  who wish to participate in the study; who can participate in at least six of the eight sessions of the mindfulness program; and who provide informed consent	Students with severe symptoms of anxiety (GAD-7 equal to or greater than 15), depression (PHQ-9 equal to or greater than 15) and severe mental disorder (self-reported); those who report experience with mindfulness, other meditations or mind-body practices such as yoga in the previous 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-7nt59gn	Early Oral Refeeding for Cancer patients undergoing Bowel Surgery	Not yet recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6097	Early oral refeeding in cancer patients undergoing colorectal surgery: a controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Empresa Brasileira de Serviços Hospitalares	Hospital Universitário Professor Alberto Antunes	https://ensaiosclinicos.gov.br/rg/RBR-7nt59gn	<NULL>	Adults and seniors; both sexes; aged 30 years or older; with a proposal to perform elective colorectal surgery due to colorectal neoplasia	Patients with limited mobility; clinical and/or postoperative complications resulting from surgery performed before the start of this study; hospitalizations for diagnostic procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-92db3n2	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Intervention	2023-05-24	<NULL>	<NULL>	6101	Evaluation of the gynecological and dermatological acceptability of a health product under normal conditions of use_Glo01.2023	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-14	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Globalpro Cosmeticos Eireli	https://ensaiosclinicos.gov.br/rg/RBR-92db3n2	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; pregnant or lactating women; participants with a history of allergy to the material used in the study; atopy history; use of vaginal cream; participants with a history of allergy to products in the tested category; recent gynecological surgeries; discharges; immunodeficiency carriers; kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the start of the study; any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7z8kn4k	Evaluate the effect of using Virtual Reality on anesthetic induction in children	Not yet recruiting	Intervention	2023-05-25	<NULL>	<NULL>	6108	Use of Virtual Reality in anesthetic induction in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-7z8kn4k	<NULL>	Pediatric patients aged 4 to 14 years; both sexes; non-carriers of hearing, visual or cognitive disabilities; who will undergo anesthetic induction	Hearing deficiency; Visual impairment; intellectual disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-4z9h7nk	Surgical treatment of acute acromioclavicular Dislocations	Not yet recruiting	Intervention	2023-05-26	<NULL>	<NULL>	6110	Surgical treatment of acute acromioclavicular Dislocations with or without ligament transfer. Randomized clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-4z9h7nk	<NULL>	Volunteers of both genders with grade IV and V acute traumatic acromioclavicular dislocation; between 18 and 65 years old; no medical contraindications to general anesthesia; who accept informed consent	Individuals under 18 or over 65 years of age; dislocation with more than 21 days of evolution; presenting associated neurovascular lesion diagnosed in the physical exam and complementary exams; head trauma (Glasgow &lt;12); with associated fracture in the ipsilateral upper limb; inability to maintain outpatient clinical follow-up, that is, patients who will not be able to make the necessary returns for the correct follow-up, or because they are institutionalized, or for being followed up in other services, or other reasons that prevent them from performing the returns in consultations scheduled; with medical contraindication for surgery and/or anesthesia; patients who are unable or unwilling to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-92kyfck	Comparative study of Anterior Cruciate Ligament Reconstruction with Peroneus Longus tendon x Hamstring tendon grafts	Not yet recruiting	Intervention	2023-05-26	<NULL>	<NULL>	6111	Randomized clinical trial comparing the functional outcome of patients undergoing Primary Reconstruction of the Anterior Cruciate Ligament with ipsilateral Peroneus Longus tendon x Hamstring tendon grafts after a 2-year follow-up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92kyfck	<NULL>	Patients with anterior cruciate ligament injury with surgical indication, with or without menisci injuries; Both genders	Presence of associated ligament injuries needing reconstruction; Patients with indication of associated procedures, such as osteotomies around the knee; Presence of associated fractures or other pathological conditions of the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-5yr2xjb	Effectiveness of an intervention based on Mindfulness on Stress, Burnout and quality of life of nurses: a randomized clinical trial	Not yet recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6114	Mindfulness, quality of life, perception of Stress and Burnout in nursing professionals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Escola Paulista de Enfermagem	Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-5yr2xjb	<NULL>	Workers of both genders; of any age; working in a health institution for at least 1 year; exercise the role of nurse; be available to participate in all stages of the randomized clinical trial	Being unemployed, on vacation or on sick leave during the survey period; have a medical diagnosis of psychiatric or neurological disease; use some psychotropic medication and perform some meditative practice regularly in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-10chb63w	Use of in-office bleaching agents with different pH in combined bleaching, a randomized clinical trial	Not yet recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6118	Combined bleaching using in-office bleaching agents with pHs different: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-10	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-10chb63w	<NULL>	Healthy volunteers; both genders; minimum age of 18 years and maximum without limit; non smokers; have vital teeth free of carious lesions; non-carious in the anterior region; free from periodontal disease; and the upper right canine should be A2 or darker in color compared to the Vita Classical scale; patients must sign the Informed Consent Form after explaining the details of the research	Volunteers with previous tooth sensitivity; who never performed any type of dental bleaching; smokers, pregnant or breastfeeding women; in continuous use of medications such as analgesics or anti-inflammatories; who do not use prostheses; no restorations on the upper anterior teeth; are not using fixed orthodontic appliance; without any parafunction; no gingival recession; no endodontic treatment of anterior teeth, no severe dental discoloration (tetracycline staining or fluorosis) and visible cracks in teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-73vcyff	Triathlon performance	Not yet recruiting	Observational	2023-05-31	<NULL>	<NULL>	6123	Performance characteristics in Olympic Distance Triathlon	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de São Paulo	Centro Olímpico de Treinamento e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-73vcyff	<NULL>	triathlete; more than a year of triathlon practice; medical clearance to perform maximum physical exercise	pain and/or any injuries in the lower limbs; medical restriction for maximum effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-337hq7s	Effect of Specific and Non-Specific Exercises on pain in patients with Chronic Neck Pain	Not yet recruiting	Intervention	2023-05-31	<NULL>	<NULL>	6125	Effect of Specific and Non-Specific Exercises on pain processing in individuals with Chronic Neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-10	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-337hq7s	<NULL>	Age between eighteen and sixty-five years; both sexes; neck pain lasting three months or longer, non-specific (no known causes), with or without irradiation; presence of pain at rest and/or during active cervical movements with a score greater than or equal to three on the Numerical Pain Scale; and score greater than or equal to ten on the Neck Disability Index	Signs of radiculopathy in the upper limbs (loss of muscle strength in the myotome, sensory loss in the dermatomes and/or changes in reflexes); whiplash-associated disorder; cervicogenic headache; fibromyalgia; pregnancy; history of trauma; cervical fractures or surgeries; cervical-related rheumatic inflammatory diseases; neurological; tumors and/or medical contraindication to practice physical exercise; physiotherapy or cervical infiltration in the last three months; starting some physical activity in the last two weeks; use of analgesics, use of anti-inflammatories or muscle relaxants in the twenty-four hours prior to the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-696xwzw	Surgical versus conservative treatment for acute grade III acromioclavicular dislocation	Not yet recruiting	Intervention	2023-05-31	<NULL>	<NULL>	6126	Surgical versus conservative treatment for acute grade III acromioclavicular dislocation. Randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-696xwzw	<NULL>	Volunteers of both genders with grade III acromioclavicular dislocation; acute acromioclavicular dislocations; adults between 18 and 65 years old; no medical contraindications for the proposed treatments; acceptance and understanding of the informed consent form	Acromioclavicular dislocations grades I, II, IV, V and VI; dislocation with more than 14 days of evolution; associated neurovascular injury diagnosed on physical examination; head trauma; fracture in the ipsilateral upper limb; previous diseases in the affected limb that may influence the results; medical contraindication for surgery and/or anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-8pn8fw	Effect of Exercise on older adults that suffering falls in Mato Grosso	Not yet recruiting	Intervention	2019-09-01	<NULL>	<NULL>	6127	Functional Training for fallers older adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-07	Hospital Universitário Julio Muller	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-8pn8fw	<NULL>	Elderly fallers and non fallers; aged 65 years or older; with preservation of intellectual understanding	Cognitive alterations of clinical dementia; visual and auditory problems; labyrinthitis; chronic diseases; fatigue or signs of tiredness; heart diseases; Severe osteoporosis; severe cardiopulmonary disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-6gv37z8	Evaluation of skin and child Acceptability for Cosmetic Product	Not yet recruiting	Intervention	2023-06-05	<NULL>	<NULL>	6133	EN22-0674-03_Evaluation of dermal and pediatric Acceptability for Cosmetic Product	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-20	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-6gv37z8	<NULL>	Participants of both sexes aged between 0 and 3 months; intact skin in the product analysis region; up-to-date vaccination card; be a user of cosmetic products of the same category; parents or legal representative willing to obey the trial procedures and be available for telephone contacts and/or via WhatsApp and telemarketing, with internet access on the days and times determined for the assessments; parents or legal representative who have a mobile device suitable for use and with access to the internet network for telephone contacts and/or via WhatsApp and call center, with internet access; parents or legal representative willing to attend the Clinical Research Center if necessary for evaluations; parents or legal representative of the participants must understand and agree with the Free and Informed Consent Term (TCLE) and consent to the participation of their child	Participants and parents or legal representative who have been diagnosed with COVID-19 in the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; use of anti-inflammatory/ immunosuppressive/ antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); atopic or allergic history to cosmetic products; pathologies and/or active skin lesions (local and/or disseminated) in the assessment area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; known history of or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the evaluation; aesthetic or dermatological treatment in the evaluation area up to 04 weeks before selection; children of employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-7jt6zny	Impact of Music in childhood	Not yet recruiting	Intervention	2023-06-05	<NULL>	<NULL>	6136	Effects of Music Training in childhood: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Bravo Academia de Música	https://ensaiosclinicos.gov.br/rg/RBR-7jt6zny	<NULL>	Children with a minimum age of 180 days and maximum age of 209 days of life at the pre-intervention time; of both genders; Term born with no history of risk factor for developmental delays; parents and first-degree relatives who are not music professionals; result passes neonatal hearing screening; brainstem auditory evoked potential with presence of wave V at 30 dBnHL at the pre-intervention moment; parents or guardians have not been exposed to the formal musical approach during the gestation period	Children who present failure in neonatal hearing screening; history of disease in the first six months of life; neurological alterations; motor impairment and syndromes; external, middle and/or inner ear malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-94bszgk	Effects of association of an intensive motor training and brain stimulation on gait, balance and legs movement of people who suffered a stroke	Not yet recruiting	Intervention	2023-06-06	<NULL>	<NULL>	6139	Association of Lower Extremities - Constraint Induced Movement Therapy (LE-CIMT) and Transcranial Direct Current Stimulation (tDCS) on functionality and performance of lower limbs, gait and balance of post-stroke patients ¿ Triple-blinded, controled, randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-03	Associação de Assistência a Criança com Deficiência	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94bszgk	<NULL>	Medical diagnosis of a single Stroke with more than six months of injury; both genders; minimum age of 18 years old and maximum age of 79; clinically stable; presenting hemiparesis as a sequel to the stroke; present a gait deficit caused by the sequelae of the stroke, classified at Level 3 to 5 of the Functional Ambulation Classification; go from sitting to standing independently even with the help of upper limbs; not having undergone orthopedic surgery in the last 6 months or chemical blockade in the last 3 months prior to the beginning of the study; no history of seizures; without anticonvulsant medication	Not tolerate the electrical stimulation; lesions in the scalp region where there will be electrode contact; to present convulsive episode during the protocol; epileptic Focus on Electroencephalogram exam even with no clinical manifestation; to have brain implant; to have cardiac markpacer; diagnosed or investigating bipolarity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-973pt5n	Study of the treatment of Chronic Chagas disease and with cardiac involvement in adults based on the regions of Brazil	Not yet recruiting	Intervention	2023-06-07	<NULL>	<NULL>	6140	BENBRASIL Trial - prospective study of efficacy and safety of Benznidazole, with randomized, double-blind phase II study of Benznidazole compared to Nifurtimox in adults with Chagas Disease in chronic indeterminate or mild cardiac forms, in Brazil	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-08-01	Instituto Nacional de Infectologia Evandro Chagas	Ministerio da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-973pt5n	<NULL>	Both sexes; older than 18 years; having two positive serological tests for Chagas disease; weight between 50 kg and 95 kg	Previous treatment with Benznidazole or Nifurtimox, pregnant women, breastfeeding or expressing gestational desire for the next 2 months; Any concomitant use or documented history of use of allopurinol or antifungals ketoconazole, itraconazole and posaconazole; History of hypersensitivity, allergic or severe adverse reactions to any nitroimidazole compound and/or its components; liver disease with liver failure and kidney disease requiring supportive treatment; Sinais and/or symptoms of the severe cardiac form of Doença de Chagas; History of cardiomyopathy, heart failure, or severe ventricular arrhythmia of any etiology; Participation in another clinical trial in the last 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-3sdgfyy	Dipyrone for the acute treatment of Dialysis Headache	Not yet recruiting	Intervention	2023-06-07	<NULL>	<NULL>	6141	Evaluation of Dipyrone in the acute treatment of Dialysis Headache: a randomized, double-blind, placebo-controlled study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-06-30	Pós Graduação em Neuropsiquiatria e Ciências do Comportamento - Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3sdgfyy	<NULL>	Patients of both genders; aged 18 years or over; on hemodialysis treatment for chronic renal failure; diagnosed with dialysis headache according to the criteria of the International Classification of Headache Disorders (ICHD-3); who experience this headache during dialysis	Patients who have a known diagnosis of Acute Chronic Renal Failure; patients who are allergic to dipyrone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-10brpqhz	Evaluation of an Investigational Product in the Restructuring of the skin protection barrier	Not yet recruiting	Intervention	2023-06-09	<NULL>	<NULL>	6142	EN22-0674-05_ Evaluation of the efficacy of the Investigational Product in the Restructuring of the Cutaneous Barrier through the kinetic phase, after the Tape Stripping procedure	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-10brpqhz	<NULL>	Participants of both sexes; aged between 18 and 60 years; intact skin in the region of the forearms; agreement to follow the trial procedures and to attend the clinic on the day and times determined for applications and/or evaluations; understand, consent and sign the informed consent form	Participants diagnosed with COVID-19 in the last 4 weeks or showing symptoms such as fever, dry cough, tiredness, body aches or other discomfort; pregnancy/lactation or intention to become pregnant during the study period; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to 30 days before selection or considering immunosuppressants, the interval should be 3 months before selection; history of atopy and history of allergies to cosmetic products; pathologies and/or active skin lesions (local and/or disseminated) in the evaluation area; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); pathologies that cause suppression of immunity, such as diabetes, HIV, etc.; decompensated endocrinopathies; participants with known congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known history of or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the evaluation; aesthetic or dermatological treatment in the evaluation area up to 04 weeks before selection; professionals directly involved in performing this study; other conditions considered by the evaluating physician as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-58pm9jh	Empathy project - the use of Cognitive Behavioral Therapy in children and adolescents in the dental office	Not yet recruiting	Intervention	2023-06-14	<NULL>	<NULL>	6149	Empathy project - evaluation of Cognitive Behavioral Therapy resources in the approach to child and adolescent patients in the dental office	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-58pm9jh	<NULL>	Children and teenagers; both genders; Brazilians literate in Portuguese; who did not need emergency dental care; who had dental anxiety; it will also be essential that both children/adolescents and parents/guardians are interested in self-help therapy for inclusion in the study	Individuals who are undergoing psychiatric/psychological treatment or who have some limitation that makes it difficult for them to understand the guides will be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-7468j4q	Treatment of Diabetic macular edema with intravitreal injection of antiangiogenic agents with or without Dexamethasone	Not yet recruiting	Intervention	2023-06-15	<NULL>	<NULL>	6150	Treatment of Diabetic Macular Edema with intravitreal injection of anti-VEGF agents with or without Dexamethasone 4 mg/mL solution, randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7468j4q	<NULL>	Age equal to or greater than 18 years; both genders; diagnosis of diabetes; presence of clinically significant diabetic macular edema in at least one eye according to the ETDRS (Early Treatment Diabetic Retinopathy Study) guidelines; Best Corrected Visual Acuity between 20/400 and 20/40; Central Macular Thickness &gt;= 300 µm, measured by Spectral Domain Optical Coherence Tomography	Any diabetic macular edema treatment in the last 4 months; Panretinal photocoagulation in the last 4 months; any eye surgery performed in the last 4 months; history of Pars Plana Vitrectomy; hx of open-angle glaucoma or corticosteroid-induced elevated intraocular pressure requiring ocular antiglaucoma or antihypertensive treatment; intraocular pressure &gt;= 21 mmHg; history of allergy to any product used in the procedure; presence of tractional retinal detachment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-4tpbssz	Evaluation of blood glucose and cholesterol levels in people who ingested Acai Coffee	Not yet recruiting	Intervention	2023-06-16	<NULL>	<NULL>	6155	Evaluation of glycemic levels, total cholesterol and triglycerides after ingestion of Toasted and Ground Açaí Core Infusion	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal do Tocantins	Universidade Federal do Tocantins	https://ensaiosclinicos.gov.br/rg/RBR-4tpbssz	<NULL>	Serving professionals at the Federal University of Tocantins/UFT located on the Palmas/TO campus who wish to take part in the research and comply with the TCLE; of both genders; aged between 30 and 50 years	Pregnant and lactating participants, due to the lack of evidence that the studied herbal medicine, even if natural, may pose a risk; people with diabetes or those who during screening have blood glucose levels higher than 99 mg/dL, as the tests are carried out with glucose administration; participants with a known history of food allergy to açaí or any derivative; any other personal reasons that prevent them from carrying out the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-8y3qx39	Efficacy of nursing consultation guided by Felix&apos;s Theory in improving risk of impaired cardiovascular function: a randomized clinical trial	Not yet recruiting	Intervention	2023-06-19	<NULL>	<NULL>	6159	Effecacy of the Felix Theory-based nursing consultation in improving risk of impaired cardiovascular function: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-8y3qx39	<NULL>	Having the nursing diagnosis risk of impaired cardiovascular function; being aged ≥18 years and &lt; 60 years; both genders; being enrolled in Comprehensive Health Care Center	Reporting a diagnosis of cardiovascular disease; presenting impediments to obtaining anthropometric measurements (pregnant women, wheelchair users) or requiring instruments adapted for the execution of interventions (physically, hearing, and visually impaired), not yet developed by other researchers; being in temporary or permanently impaired mental conditions that make it impossible for them to be aware of and cooperate with the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-6dpzvty	Effect of Amitriptyline Cream on Muscle and Joint Pain	Not yet recruiting	Intervention	2023-06-19	<NULL>	<NULL>	6160	Effect of Base Cream with 5% Amitriptyline on Orofacial Pain: Muscle and Joint	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6dpzvty	<NULL>	Age equal to or greater than 18 years; Undergraduate and postgraduate students at the Piracicaba School of Dentistry; Complaint of persistent facial and/or joint pain (TMJ) present for at least 3 months that corresponds to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) (Pereira and Gonçalves, 2020; Schiffman, 2014). The diagnostic nomenclature of Axis I and Axis II of DC/TMD will be used; Having accepted and signed the Informed Consent Form	Under 18 years old; Present other pain syndromes; Refusal to adhere to treatment using topical drugs; Report an allergy to any component of the formula; Make use of antidepressant, anticonvulsant and anti-inflammatory; Be under the direct supervision of the researchers (developing some type of activity in undergraduate and postgraduate courses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-6td87pq	Minimum Effective Volume of local anesthetic for Ultrasound-guided PENG Block.	Not yet recruiting	Intervention	2023-06-21	<NULL>	<NULL>	6167	Minimum Effective Volume for Ultrasound-guided PENG Block	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6td87pq	<NULL>	Patients with chronic hip pain, defined as pain for more than 3 months, and with indication for hip joint arthroplasty due to osteoarthritis.	Patients allergic to local anesthetics or the contrast agent used. Patients addicted to alcohol or illicit drugs. Weight &lt; 50 kg. Morbid obesity defined as body mass index (BMI) &gt; 40 kg/m2. Pregnant women. Patients with previous sensory alterations in dermatome of femoral or obturator nerves. Patients with cognitive impairment who are incapable of understanding the study and signing the informed consent form. Patients with skin infection at the puncture site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-8wdrwhs	Do the characteristics of the Bite-Stabilizing Plate change depending on how it is printed?	Not yet recruiting	Intervention	2023-06-23	<NULL>	<NULL>	6174	Prosthetic properties of the Interocclusal Stabilizing Device, do they change according to the impression angle? A randomized crossover blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Uberlândia - Faculdade de Odontologia	Universidade Federal de Uberlândia - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-8wdrwhs	<NULL>	Patients with a probable diagnosis of Sleep Bruxism (SB); with discomfort in the masticatory muscles; apparent hypertrophy of the masseter; history of teeth grinding during the night; healthy oral mucosa, absence of systemic diseases; the autonomy of behavior and expression; both genders; over 18 years old	Patients diagnosed with moderate and severe Obstructive Sleep Apnea; absence of one or more molars; patients with upper removable dental prostheses; patients undergoing orthodontic treatment; patients with neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-2dqd733	Effect of ozone gel on pain, swelling and limitation of mouth opening after wisdom tooth extractions in the same patient, one side using the gel and the other not	Not yet recruiting	Intervention	2023-06-26	<NULL>	<NULL>	6176	Effect of ozonized gel on the control of pain, edema and trismus in patients undergoing mandibular third molar extractions: a randomized split-mouth clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-21	Faculdade de Ciências da Saúde da Universidade de Brasília - UnB	Faculdade de Ciências da Saúde da Universidade de Brasília - UnB	https://ensaiosclinicos.gov.br/rg/RBR-2dqd733	<NULL>	Volunteers of both sexes; age between 18 and 30 years; healthy; do not use any medication; having (radiographically evaluated) the two lower third molars in position B and class II of the Pell &amp; Gregory Classification	Volunteer with systemic disease; pregnant; lactating woman; smoker; patient with an infectious process or tumor; person who presents incompatibility with standardized medication; patient who has and wishes to extract upper third molars (provided they are indicated) in the same surgical intervention; patient who wants to extract both lower third molars in the same session	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-10qh48qj	Effect of the combination of platelet-rich fibrin with deproteinized bovine bone on bone formation after pre-radiotherapy tooth extraction in head and neck cancer patients	Not yet recruiting	Intervention	2023-06-26	<NULL>	<NULL>	6177	Effect of combined PRF with deproteinized bovine bone on bone formation after pre-radiotherapy tooth extraction in head and neck cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-10	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10qh48qj	<NULL>	Patients diagnosed with head and neck cancer; both genders; age above 18 years; with indication and need for pre-radiotherapy tooth extraction and who provide consent to participate in this research project by signing the free and informed consent form	Minor patients; patients who do not agree with the free and informed consent form; patients with advanced tumors who, due to the urgency of starting radiotherapy, do not have enough time to perform tooth extractions; patients with health alterations that contraindicate surgical procedures for tooth extraction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-10kxn5rs	Effectiveness of the Pikluc® to relieve pain of intramuscular injection in children and adolescents	Not yet recruiting	Intervention	2023-07-03	<NULL>	<NULL>	6194	Effectiveness of the Pikluc® Device for pain relief associated with intramuscular injections in children and adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-10kxn5rs	<NULL>	Medical indication for intramuscular injection, in the right or left ventro-gluteal region or right or left deltoid region; to have the possibility of body weighing and height measurement; to be aged between 4 and 15 years; both genders	Cognitive deficit; psychiatric disorders; diseases that felt sensitivity to pain; having ingested substances that affect sensitivity to pain; people who underwent invasive procedures on the same day as the intramuscular injection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-10fg77vk	Effects of cupping therapy on pain intensity, fatigue and performance after a 10km run	Not yet recruiting	Intervention	2022-01-28	<NULL>	<NULL>	6197	Effects of sliding cupping therapy on pain intensity, fatigue perception and muscular performance after a 10km run	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	Caio Alano de Almeida Lins	https://ensaiosclinicos.gov.br/rg/RBR-10fg77vk	<NULL>	"Street runners for at least 1 year who run twice a
week; Being able to run 10 km continuously in the time interval between 40 and 60 minutes in at least one training session; Be between 18 and 45 years old; Not present severe cardiorespiratory or metabolic alterations, proven by a medical report; Not reporting the presence of musculoskeletal disorders in the lower limbs, in the last 6 months, that have prevented the maintenance of the training routine; Do not report any of the contraindications for the application of cupping therapy; Never having used cupping therapy"	"Presenting disorders in the quadriceps femoris, such as hematoma and cramp, during
study procedures; Present allergy or skin irritation due to the use of vegetable oil necessary for cupping therapy; Not being able to complete the 10km run within 60 minutes; Failure to correctly perform the assessment procedures; Not attending any stages of collection development; Make use of anti-inflammatory drugs, corticosteroids, analgesics or muscle relaxants during the collection period or in the 30 days preceding the beginning of the study; Make use of ergogenic resources, such as anabolic steroids, in the last 6 months prior to the start of collection; Carry out another type of intervention for muscle recovery during the development of the research; Refusing to sign the Free and Informed Consent Form (ICF)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-239fmgx	Oya Care protocol for management of the health of patients with ovaries	Not yet recruiting	Observational	2023-07-04	<NULL>	<NULL>	6198	Oya Care protocol for healthcare of patients with ovaries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-23	Fundação do ABC - Faculdade de Medicina do ABC	Fundação do ABC - Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-239fmgx	<NULL>	Patients with ovaries; patients aged at least 18 years; patients of any race, skin color and ethnics; patients of any sexual orientation; patients of any gender identity; patients of any social status; patients of any social group	Patients aged less than 18 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-6r3q4zn	Effects of home Exercise Technology for the elderly	Not yet recruiting	Intervention	2023-07-04	<NULL>	<NULL>	6199	Development and Evaluation of Home Exercise Technology for the elderly: Heeh Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Universidade de Brasília	Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6r3q4zn	<NULL>	Both sexes; age between 60 and 80 years; be registered and monitored at the Ambulatory; own or have relatives in the same household who have a smartphone that supports the application with internet access; be available to attend the monthly consultations carried out throughout the study; being independent in activities of daily living, through the Barthel index; non-practitioners of physical activity or insufficient physical activity, assessed using the International physical activity questionnaire (IPAQ), an instrument that assesses the level of physical activity	Age greater than 80 years; chronic complications of DM (neuropathy; nephropathy, retinopathy, limb amputation and diabetic foot); participate in another clinical trial, research study, or exercise program where they perform similar balance and strength activities; having mobility limitations or using walking devices; diagnosis of progressive neurological disease or other acute or unstable medical condition that precludes performing the exercises; make use of medications that interfere with balance; failing to perform any evaluation proposed in the study protocol; presenting cognitive impairments assessed through the Mini Mental State Examination (MMSE) - the cutoff scores used for exclusion will be: 17 for illiterates; 22 for seniors with between 1 and 4 years of schooling; 24 for those with between 5 and 8 years of schooling and 26 for those with 9 or more years of schooling; and those with mobility deficits – Timed Up-and-Go (TUG) over 20 seconds, a timed test that assesses walking speed, balance and risk of falling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-32qgytk	The effect of Social Skills on the marital relationship of people with Anxiety symptoms	Not yet recruiting	Intervention	2023-07-10	<NULL>	<NULL>	6219	Social Skills training in people with Anxiety and marital satisfaction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-07	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-32qgytk	<NULL>	Participants over 18 years old; minimum of 1 in the affective relationship; low repertoire of social skills; anxiety symptoms; marital dissatisfaction	Participants with diagnosed psychiatric disorder; who are under psychological and/or psychiatric follow-up; couples who both volunteer; participants with approximation or any kind of bond with the interns who will carry out the interventions; incompatibility with the time of the intervention; psychology students or psychology professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-2h6gdh7	Product Efficacy evaluation for Children&apos;s Diaper Rash	Not yet recruiting	Intervention	2023-07-11	<NULL>	<NULL>	6224	EN22-0674-04 – Comparative evaluation of the Efficacy of two products in improving Diaper Rash in children - clinical and subjective study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-2h6gdh7	<NULL>	Participants of both sexes; age between 3 months and 2 years and 11 months; diaper wearers; with irritant diaper dermatitis; with mild to moderate intertrigo, mild or clear erythema, without maceration, erosion or signs of infection in the area where the diaper is used; at least one parent or legal responsible willing to follow the trial procedures and attend the clinic on the days and times determined for applications and/or evaluations; at least one parent or legal responsible of the participants must understand, agree and sign the Informed Consent Form (TCLE)	Participants and parents or legal responsible who have been diagnosed with COVID-19 in the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; use of anti-inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; atopic or allergic history to cosmetic products; immunosuppression by drugs or active diseases; decompensated endocrinopathies; known history of or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the assessment; aesthetic or dermatological treatment up to 4 weeks before the evaluation; children of employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-5rmxgnb	&quot;Comparing the Well-being of Physicians  Network-Based Medical Residency of the Department of Public Health of the City of São Paulo and of Irmandade da Santa Casa de Misericórdia de São Paulo&quot;	Not yet recruiting	Observational	2023-07-12	<NULL>	<NULL>	6230	Comparative Study on the Well-being of Resident Physicians of the Network-Based Medical Residency of the Department of Public Health of the City of São Paulo and of Irmandade da Santa Casa de Misericórdia de São Paulo	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5rmxgnb	<NULL>	Resident physicians ; both sexes ; between 18 and 60 years old ; agree to participate in the study	Non-agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-5qq46rb	Effectiveness of an intervention on physical activity and eating behavior in adolescents	Not yet recruiting	Intervention	2023-07-12	<NULL>	<NULL>	6232	Effectiveness of a school-based intervention on stages of behavior change related to physical activity and diet in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5qq46rb	<NULL>	First year high school students; regularly enrolled in the selected schools; of both genders; between 13 and 18 years of age; not having physical and/or mental limitations that would prevent their participation in the stages of the study; having parental consent through the signing of the TCLE (Free and Informed Consent Form); having agreed to and signed the TALE (Free and Informed Consent Form)	Students not enrolled in the first year of high school in the selected schools; not meeting the minimum and maximum ages established; having physical and/or mental limitations that prevent their participation in the stages of the study; not having parental consent through the signing of the TCLE (Free and Informed Consent Form); not having agreed to and signed the TALE (Free and Informed Consent Form)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9jynn64	Intervention based on mindfulness on levels of emotional response, mindfulness and stress in nursing students: clinical trial randomized	Not yet recruiting	Intervention	2023-07-12	<NULL>	<NULL>	6234	Mindfulness based intervention on levels of emotion regulation, dispositional mindfulness and perceived stress in nursing students: clinical trial randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Univerdidade do estado de Mato Grosso	Univerdidade do estado de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-9jynn64	<NULL>	Students regularly enrolled in the ninth and tenth phase of the undergraduate nursing course; over eighteen years old	Have previously participated, at least once a week, in some type of meditation in the last twelve months; being under treatment with the use of psychotropic drugs; have physical contraindications to the exercises that will be performed during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-4x9kcbf	Reduction of Heart Issues in individuals with Paraplegia through Physical Activity	Not yet recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6237	Reduction of Cardiovascular Combities in people with Paraplegia through a Physical Rehabilitation Program	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-13	Faculdade de Medicina de Campos	Faculdade de Medicina de Campos	https://ensaiosclinicos.gov.br/rg/RBR-4x9kcbf	<NULL>	Eligibility criteria will be age between 18 and 65 years, chronic spinal cord injury more than1 year post-injury; self-reported wheelchair use for more than 75% of your waking day; stable weight in the past 3 months	Individuals who self-report the use of medication for type 2 diabetes or medication that affect glucose metabolism and those who have a fracture or dislocation; uncontrolled inflammatory disease or those prevented from performing physical activity for any clinical reason will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9gtr9sc	Effect of Tooth Enamel humidity on Tooth Whitening using High-concentration Carbide Peroxide: A Randomized Clinical Trial	Not yet recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6240	Effect of Enamel humidity on the action of High-concentration Carbide Peroxide: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-24	Universida Federal de Sergipe	Universida Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9gtr9sc	<NULL>	Any individual who is interested in teeth whitening at least 18 years of age, patients who have a color equal to or darker than 2.5 M2 on the maxillary anterior canines (on the Vita Bleach Guide scale) and agree to participate and sign the informed consent form	Presence of restorations in the upper anterior teeth, presenting any pre-existing general medical and/or oral condition that put the individual at risk during the study, such as systemic fungal infections, being pregnant or breastfeeding, dental treatment planned to be performed during the course of the study , generalized periodontal disease, complex intrinsic staining due to tetracycline, fluorosis or hypocalcification, and previous tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-4pc8c47	Physiological and psychological responses promoted by a beach tennis session	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6247	Comparison of physiological and psychobiological responses promoted by a beach tennis session in single and double mode	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4pc8c47	<NULL>	Age between 18 and 40 years; both sexes; minimum of two months of experience in beach tennis; be literate	Contraindication for performing physical activity (PAR-Q); having some type of musculoskeletal injury; being on your period; discontinuity in the research and e) not having the complete immunization cycle of COVID-19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9ghqkdx	Effect of systemic Corticosteroid use after Maxillary Sinus Lift Surgeries	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6248	Postoperative Period inMaxillary Sinus Lift	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-31	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9ghqkdx	<NULL>	Volunteers patients (18 years of age or older); both sexes; patients in need of maxillary sinus lift surgery	Volunteers with previous chronic or acute pain; volunteers in chronic or acute systemic use (in the 48 hours prior to the procedure) of analgesic, anti-inflammatory and/or muscle relaxant; volunteers with difficulty in understanding instructions (cognitive changes), which impair the application of the scales proposed by the study; illiterate volunteers; volunteers with contraindications for the use of paracetamol associated with codeine; volunteers with contraindication for the use of dexamethasone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-47nqzj2	Effects of Osteopathic Manipulative Treatment in women with Intestinal Constipation	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6249	Effects of Osteopathic Manipulative Treatment in women with Functional Constipation: pragmatic randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Univerisade Estadual do Oeste do Paraná	Univerisade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-47nqzj2	<NULL>	Women; age range from 18 to 60 years; present functional constipation as mentioned in the ROME III criteria (LONGSTRETH et al., 2006)	Not accepting manipulations; pregnant women; being in the inflammatory phase of gastrointestinal or urinary diseases (kidney stones, appendicitis, colicistitis, peritonitis); presenting metabolic or cardiovascular diseases; having already undergone some surgical procedure on the spinal column or abdominal cavity; having undergone some type of treatment for constipation less than 6 months ago, such as: use of laxative medications and body massages or teas that alter intestinal motility; present contraindications for the Osteopathic techniques to be performed during the collection of the study, these being: recent fracture, osteoporosis and spinal tumor (PANAGOPOULOS et al. , 2015; FERNANDES et al., 2018)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9d23t9t	The effect of using an application in the care of Overweight or Obesity adults in Primary Health Care	Not yet recruiting	Intervention	2023-07-21	<NULL>	<NULL>	6260	Efficacy of interventions mediated or not by Technologies in the care of Overweight or Obesity adults in Primary Health Care: A trial randomized community	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Ouro Preto	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-9d23t9t	<NULL>	People who are overweight or obesity (BMI ≥ 25Kg/m2): adults over 18 and under 60 who have a compatible device and availability/interest to download the mobile app.	"Children; adolescents; pregnant women; elderly with or without excess weight and
obesity; Adult users in drug treatment for obesity; Adult users with body weight over 200kg."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-2gdd984	Effect of the use of two different types of dental motors on the perception of pain, swelling and difficulty opening the mouth postoperatively in Dental Extractions of lower wisdom teeth: a double-blind randomized clinical trial in a split-mouth	Not yet recruiting	Intervention	2023-07-24	<NULL>	<NULL>	6263	Effect of using a 1:3 multiplier surgical contra-angle versus high-speed pen on the perception of postoperative pain, edema and trismus in mandibular third molar Extraction: a double-blind randomized clinical trial in a split mouth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-25	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2gdd984	<NULL>	Will be included in the study, 24 patients aged between 18 and 30 years and without impairment of general health according to medical history (healthy) and physical examination, who agree to participate in the study. Through clinical and radiographic examination, patients with indication for bilateral extraction of mandibular third molars, asymptomatic and in class IIB position, according to the Pell &amp; Gregory classification, will be selected.	Exclusion criteria will be considered: (I) history of use of any type of analgesic, anti-inflammatory and antibiotic medication in the 15 days prior to the beginning of the surgical procedure; (II) history of hypersensitivity to drugs, substances or materials used in this experiment; (III) pregnancy or lactation; (IV) pericoronitis or other local infection within 15 days prior to the surgical procedure; (V) and people with a history of acute or chronic systemic disease, such as hypertension or diabetes, for example.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-8tqs3cc	Immediate Effect of Electrical Stimulation on the Scalp on heart measurements in patients with Stroke	Not yet recruiting	Intervention	2023-07-24	<NULL>	<NULL>	6267	The immediate Effect of Transcranial Direct Current Stimulation (tDCS) on Cardiorespiratory parameters in adult hemiparetic patients with to stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8tqs3cc	<NULL>	Hemiparetic adults diagnosed with Chronic Stroke;  with lesions in the left or right hemisphere; aged between 49 and 71 years; able to walk independently; have signed the consent document	Participants with cognitive deficits; visual impairment; severe heart problems; pacemaker use; transcranial Direct Current Stimulation contraindications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-64g476p	Comparative evaluation of At-home bleaching in patients with two different age groups - a parallel, single-blind, non-randomized controlled trial.	Not yet recruiting	Intervention	2022-04-06	<NULL>	<NULL>	6270	Clinical evaluation of the efficacy of at-home dental bleaching in patients of different age groups	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-64g476p	<NULL>	Patients aged between 15 and 24 years (young patients); patients between 45 and 59 years old (middle-aged adult patients); elderly patients (60-80 years); presenting a good state of general and oral health; absence of caries; absence of restorations bigger than 1/3 of tooth structure and endodontic treatment in anterosuperior teeth; with upper right canine (element 13) the participants must present color A2 or lesser value according to the value-oriented color scale (Vita Classical, Vita Zahnfabrik, Bad Sa¨ckingen, Germany).	Participants using an orthodontic appliance; severe internal discoloration of the tooth (tetracycline stains, fluorosis and non-vital teeth); bruxism; pregnant / lactating women; use of medications (analgesics or anti-inflammatory drugs); participants who had already undergone previous tooth whitening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-5996nhj	The efficacy and safety of Cannabis Extract in muscle pain control	Not yet recruiting	Intervention	2023-07-25	<NULL>	<NULL>	6272	"Evaluation of the efficacy and safety of Full Spectrum Cannabis Extract, in pain control, in patients with Muscular Temporomandibular Disorder
Clinical, randomized, double-blind, placebo-controlled trial"	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-01-01	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	Sociedade Brasileira de Estudo de Cannabis Sativa	https://ensaiosclinicos.gov.br/rg/RBR-5996nhj	<NULL>	Patients at least 18 years old; both genders; able to understand the questions applied in the tests selected for the research; totally or partially dentate patients with a maximum absence of two (2) teeth per hemi-arch or rehabilitated by fixed prosthesis; patients with presence of Temporomandibular Muscle Dysfunction - TMD according to Axis I (CD/TMD) (Schiffman et al., 2014), whose main complaint of muscle pain is for a period longer than 3 months; patients who sign the Informed Consent Form	Patients with serious diseases, trigeminal neuralgia, tumors, neurological diseases, and psychological problems; patients with total prosthesis; people diagnosed with dental malocclusions and/or presenting with a difference between the central and maximum intercuspation ratio greater than 5 mm, overjet and overbite greater than 6 mm, and anterior or unilateral crossbite; people who have had previous history of Temporomandibular Joint - TMJ surgery, degenerative diseases and neuropathic pain; pregnancy; presence of primary headaches; people allergic to the formulation of the substance used in the study; patients with a history of psychiatric disorders, such as schizophrenia, or a family patients with a history of psychiatric disorders such as schizophrenia or a family history of this disorder; patients taking (or who have taken in the last 3 months before the beginning of the study) of any cannabis product (Liability Waiver present in Appendix 3); patients whose work requires toxicological tests, such as drivers and machine operators, competitive athletes in activities and members of the armed forces, since the substance can lead to labor losses by prohibition of these entities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-10w787j6	Effect of Transcranial Stimulation and Aerobic Training in patients with Heart Failure on physical capacity and inflammatory profile	Not yet recruiting	Intervention	2023-04-04	<NULL>	<NULL>	6274	Effect of Transcranial Direct Current Stimulation associated with Aerobic Training in patients with Heart Failure on physical capacity and inflammatory profile: controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-08	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-10w787j6	<NULL>	Patients aged over 18 years; Both sexes; Ejection fraction (EF) below 40%; Functional class II or III according to NYHA (New York Heart Association); Who are on optimized clinical treatment	Orthopedic dysfunctions that prevent physical exercise (such as, for example, osteoarthritis in the lower limb and/or spine); Neurological and/or cranial alterations that prevent the application of tDCS (Transcranial Direct Current Stimulation); Diagnosed seizures; Unstable angina symptoms; Patients using a pacemaker or implantable ventricular defibrillators; Metabolic syndromes linked to thyroid or liver; Body mass index (BMI) less than 18.5 and greater than 34,9; Patients with less than 3 months of cardiac decompensation; Patients undergoing cardiovascular rehabilitation in the last 12 months; Patients with cognitive disorders, assessed by the Mini Mental State Examination (MMSE) with a lower score in their education category; Uncontrolled diabetes, systemic arterial hypertension and dyslipidemia; Diagnosed lung disease, such as exercise-induced asthma and pulmonary fibrosis; Pregnant women; Smokers; Alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-6kw6qnx	The effect of an application for cell phones and tablets on medication adherence of elderly people with Systemic Arterial Hypertension	Not yet recruiting	Intervention	2023-07-27	<NULL>	<NULL>	6279	Therapeutic adherence of elderly patients with arterial hypertension: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-15	Universidade de Brasília	Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6kw6qnx	<NULL>	Elderly aged 65 years or older, with stage 1 or 2 SAH; with uncontrolled blood pressure in at least 2 consultations; who use at least 1 daily medication for at least 1 year; who has a cell phone with memory space and internet access; elderly people classified in Profile 1 and 2 of functionality for care purposes, in the Line of Care for Comprehensive Health Care for the Elderly; not practicing physical activity or showing insufficient physical activity, assessed using the short version of the International Physical Activity Questionnaire (IPAQ).	Illiterate elderly will be excluded; who have some physical or intellectual impediment that prevents them from using the application or mobile device; patients with Chronic Kidney Disease and who have a self-reported medical diagnosis of dementia, delirium, psychotic or substance-related mental disorders according to DSM-5 criteria and those who do not complete the research steps; elderly people who present cognitive impairments evaluated through the 10-CD Cognitive Test in which the cutoff scores used for exclusion will be: 17 for the illiterate; 22 for seniors with between 1 and 4 years of schooling; 24 for those with between 5 and 8 years of schooling and 26 for those with 9 or more years of schooling; elderly people with mobility deficits using the Timed Up-and-Go (TUG) scale over 20 seconds, a timed test that assesses gait speed, balance and risk of falling; seniors participating in another clinical trial; research study or exercise program where they perform similar balance and strength activities; and those who have mobility limitations or use walking devices; diagnosis of progressive neurological disease or other acute or unstable medical condition that precludes performance of the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-5wy4vhx	Randomized clinical trial: how a plant called Eclipta prostrata (commonly known as false daisy) can help people with Obesity	Not yet recruiting	Intervention	2023-07-28	<NULL>	<NULL>	6282	Randomized clinical trial: effect of the herbal medicine from Eclipta prostrata (L.) L. (Asteraceae) on phase angle in adults with grade I Obesity	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5wy4vhx	<NULL>	Adults of both genders; aged 18 to 59; with grade I obesity; monitored in primary healthcare unities	Participants with comorbidities characterized by low-grade chronic inflammation, except for those associated with obesity and metabolic syndrome; history of chronic use of corticosteroids, immunosuppressants, or nonsteroidal anti-inflammatory drugs; health conditions that may interfere with the parameters measured by bioelectrical impedance analysis, such as edema, chronic kidney disease, end-stage organ failure, or amputated limbs; implanted cardiac devices; chronic diarrhea; ethical restrictions that prevent proper consent for study participation; women who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-294pmdq	The effect of Activities in Contact with Nature on adults&apos; Depressive Symptoms	Not yet recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6297	Activities in Contact with Nature and Symptoms of Depression in adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Estadual de Santa Cruz	Universidade Estadual de Santa Cruz	https://ensaiosclinicos.gov.br/rg/RBR-294pmdq	<NULL>	Be 18 years of age or older. Both genders. Be able to answer the survey questionnaire. Attend weekly spaces at the State University of Santa Cruz. Have time availability to participate in the activities that will be promoted	Participants who have medical restrictions to carrying out the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8hv4fms	Video that helps to reduce the anxiety of patients with HIV/AIDS	Not yet recruiting	Intervention	2023-08-01	<NULL>	<NULL>	6302	Effectiveness of audiovisual resource in the acquisition of knowledge and reduction of the level of anxiety of patients with HIV/Aids: randomized blind trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-10	Daniele Vieira Dantas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8hv4fms	<NULL>	age 18 years or older; of both sexes; having been diagnosed with HIV, being admitted to Hospital Giselda Trigueiro with a recent diagnosis of HIV; be hospitalized at Hospital Giselda Trigueiro for at least 24 hours	patients who present: have been diagnosed with AIDS with knowledge of HIV prior to hospitalization; have a reduced level of consciousness or psychomotor agitation; communication difficulty; visual and auditory deficit that impairs your ability to see and hear; be under sedation, physiological or induced coma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-49dk634	Effects of Pelvic Floor Training in the preoperative period of Radical Prostatectomy on Urinary Incontinence and Erectile Dysfunction	Not yet recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6304	Effects of a Pelvic Floor Muscle Training Program in the preoperative Radical Prostatectomy on Urinary Incontinence and Erectile Dysfunction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-20	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-49dk634	<NULL>	Men between 55 and 80 years of age; localized prostate cancer	Patients with metastatic cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8trwmwd	Effects of the amount of muscle mass involved in aerobic exercise on state anxiety level in young women exposed to unpleasant stimuli	Not yet recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6305	Effects of the amount of Muscle Mass involved in Aerobic Exercise on State Anxiety level in young women exposed to Unpleasant Stimuli	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8trwmwd	<NULL>	Women; aged between 18 and 40 years	Are in menstrual period; pregnant; contraindication for performing physical activity (PAR-Q); anxiolytic treatment of any kind; dysfunction (cardiac, endocrine, orthopedic and metabolic) self-reported that may interfere with performance; are not literate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-7pzb4sw	The effects of flower essence therapies on people with alcohol withdrawal	Not yet recruiting	Intervention	2023-08-07	<NULL>	<NULL>	6316	Efficacy of Bach Flower Remedies in individuals with down Syndrome Alcohol Abstinence: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7pzb4sw	<NULL>	Female and male users, have a diagnosis of disorder related to alcohol abuse, be 18 years old or older, have been admitted to CAPS AD III, have an up-to-date Single Therapeutic Project (PTS), have been previously diagnosed with Down Syndrome Mild/moderate alcohol abstinence and being in overnight care (24-hour monitoring) for the first time.	Users who make use of multiple drugs, who have a previous allergy to any component of the Bach Flower Remedies, who for some reason have evaded the service, or any situation that interrupts continued follow-up (evasion or transfer to another device in the healthcare network). health).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-7gbffqc	Does nurse counseling reduce anxiety in women starting assisted reproductive treatments?	Not yet recruiting	Intervention	2023-08-09	<NULL>	<NULL>	6320	Nursing consultation to reduce anxiety in women starting assisted reproductive technology treatments: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7gbffqc	<NULL>	Infertility; IVF/ICSI	Intrauterine insemination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-825ymxq	Randomized clinical trial comparing different treatments for Dental Fluorosis	Not yet recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6327	Effectiveness of different treatment protocols for Dental Fluorosis: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-825ymxq	<NULL>	Presenting a minimum of four anterior and/or superior teeth affected by dental fluorosis in the range of 1 to 6 according to the Thylstrup and Fejerskov Index; demonstrating good oral health condition (absence of active caries or periodontal disease in the anterior and/or superior and inferior teeth); being at least 15 years of age; having good general health condition (absence of cardiac problems, hypertension, or uncontrolled diabetes); showing an interest in improving the appearance of stained teeth	Presence of structural defects on the enamel surface; loss or fracture of any upper element; evidence of significant malocclusion; pregnant or lactating individuals; individuals undergoing orthodontic treatment; history of previous dentin sensitivity; restorations involving more than 1/6 of the vestibular face of any of the six anterior and/or inferior teeth; severity of fluorosis greater than 6 according to the Thylstrup and Fejerskov Index; history of prior treatment for dental fluorosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-8g25rh4	Effect of non-invasive Brain Stimulation on functionality and concurrent tasks in people with Diabetes Mellitus: a randomized clinical trial	Not yet recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6329	Effect of Transcranial Direct Current Stimulation on functional performance and dual task of individuals with Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal do Amazonas	Faculdade de Educação Física e Fisioterapia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8g25rh4	<NULL>	adults; not elderly; diagnosed with Type 2 Diabetes Mellitus; able to walk independently without the use of a walking aid; no history of diabetic neuropathy; vestibulopathy; retinopathy; nephropathy; neurological or orthopedic disease that affects gait quality, such as poliomyelitis; Brain stroke; parkinson, cerebellar ataxia; lower limb fracture; knee or hip replacements; congenital clubfoot; Charcot arthropathy; lameness of any etiology	presence of plantar ulcers; diagnosis of epilepsy; materials surgically implanted in the head or neck; use of psychotropic medication; known allergies to tDCS preparation materials; history of psychiatric illness or previous neurosurgical procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-2qpm3gt	Physiotherapeutic Exercises in Perineal Pain in Women with Endometriosis	Not yet recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6334	Application of a Physiotherapeutic Protocol in the Pelvic Dysfunctions of women With Deep Endometriosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2qpm3gt	<NULL>	For the groups (intervention group A and control group B), women in menacme; over 18 years old and up to 50 years old; diagnosed with deep endometriosis through surgery or diagnosed by imaging (ultrasound or MRI) will be included. performed by a specialist in the area) and hormone treatment for at least six months; who still had pelvic pain and/or dyspareunia (depth) associated or not with other pain complaints (dysmenorrhea, dyschezia and dysuria)	For both groups (intervention group A and control group B), the following exclusion criteria will be adopted: not having coitarche; spontaneous or surgical menopause; immediate gestational desire; presence of cognitive alterations that make it impossible to apply questionnaires and physical disabilities that make it impossible to apply the physical assessment techniques and perform the exercises in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-5snf9q3	The effect of Auriculotherapy in reducing pain in elderly people with Low back pain	Not yet recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6341	Efficacy of Auriculotherapy in reducing pain levels in elderly people with Low back pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-30	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5snf9q3	<NULL>	Elderly aged 60 years or older, of both sexes, who are being treated at the Basic Health Units, and/or attending the selected elderly centers and who accept to participate in the research by signing the Free and Informed Consent Term will be included.	Elderly people who have some physical and mental limitation to participate in the research will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-9gffcgq	Effects of a goal-oriented collaborative intervention associated with home positioning strategies for non-ambulatory children with cerebral palsy	Not yet recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6342	Effects of a goal-directed collaborative intervention with postural management strategies by telehealth in children with non-ambulant Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9gffcgq	<NULL>	Children aged 1-5 years with a diagnosis of cerebral palsy (CP) VERIFICAR SIGLAS , classified at levels IV and V of the Gross Motor Function Classification System (GMFCS), who receive conventional Physical Therapy 1 or 2 times a week, in the state of Minas Gerais, Brazil.	Children with clinical instability, tracheostomy or oxygen dependents; or those who had undergone surgery or botulinum toxin injections in the last six months. Those who are currently participating in an intensive physiotherapy protocol will only be included when the protocol ends and three months after they return to the Conventional Physical Therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-10bzg6v2	Usability of a 3D Printed Face Shield Prototype for Intensive Care Professionals: Pragmatic Clinical Trial	Not yet recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6344	Usability Evaluation of a High Fidelity Face Shield Prototype Developed for Intensive Care Health Professionals: Pragmatic Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-30	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10bzg6v2	<NULL>	Nursing professionals working in intensive care units	Professionals on probationary period (less than 3 months in the hospital); professionals in the process of dismissal (with prior notice); pregnant professionals; intolerance or allergies (formal or declared) to face shield materials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-10g7v5bx	Treatment of people with a sprained ankle at different stages of the injury	Not yet recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6350	Rehabilitation of individuals with ankle sprains in their different stages	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10g7v5bx	<NULL>	Participants must have experienced an ankle sprain within 96 hours prior to the day of evaluation; present visible swelling in the ankle region as a consequence of the sprain; at least 15 years old; both genders	People with ankle or foot fractures diagnosed after the sprain; presence of systemic or hormonal edema related to cardiac and renal problems; pregnancy; treatment with an immovable plaster cast; any reported neurological, musculoskeletal, cardiovascular, pulmonary, or metabolic conditions that may interfere with or contraindicate the research procedures will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-28xttdt	Effects of ear Acupuncture on the mental health of nursing professionals	Not yet recruiting	Intervention	2023-08-15	<NULL>	<NULL>	6353	Effects of Chinese Auricular Acupuncture on Compassion Fatigue and emotional health of nursing professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Hospital Universitário Júlio Muller	Hospital Universitário Júlio Muller	https://ensaiosclinicos.gov.br/rg/RBR-28xttdt	<NULL>	nursing professionals with at least 6 months of practical experience; who work in sectors that provide direct care to patients; that you have answered all the questions in the questionnaires; who have available time to participate in the stages of the research, and who agree to participate in the research by signing the Free and Informed Consent Term	having a previously diagnosed severe psychiatric disorder in continuous use of psychotropic medications; being pregnant, on vacation, or on leave during the intervention period; act only in administrative functions; presenting skin lesions, infection, inflammation or injury to the ear; allergic to adhesive tape in the pavilion; excessive oiliness in the ear; use a hearing aid; use steroidal anti-inflammatory drugs or opioid analgesics; to have  coagulation disorders, or to use anticoagulants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3dp727r	Effects of Exercise Training with body weight in Hypertensive individuals	Not yet recruiting	Intervention	2023-08-16	<NULL>	<NULL>	6355	Acute and chronic effects of Exercise Training with body weight in Hypertensive individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de São Paulo	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-3dp727r	<NULL>	The inclusion criteria will include individuals who: are male; are hypertensive through a previously requested medical report; whose hypertension is controlled by medication; are between 30 and 50 years old; have been sedentary for at least a period of 6 months; hold medical clearance to practice physical exercise; do not present injuries that limit the partial or total practice of physical exercise; agree to be volunteers for the realization of this project; provide personal and health information; perform pre-participation assessments of the exercise program; sign the free and informed consent form (TCLE)	Participants who change their drug treatment during their participation in the research and who, during the 17-week training period, have a frequency below 75% will be excluded from the analyses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-10t3wc7z	Development and evaluation of flexible sensor devices and construction of plasmid positive controls for molecular diagnosis and detection of residual disease in Leukemia	Not yet recruiting	Observational	2023-08-18	<NULL>	<NULL>	6361	Accuracy of a flexible nanodevice based on DNA probes and conductive polymers for ultrasensitive diagnosis of chimeric oncogenes associated with childhood Lymphocytic Leukemia in health units in Brazil and therapeutic decision under the Brazilian Childhood Leukemia Treatment Group (GBTLI) protocol - 2020	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Instituto Aggeu Magalhães - Fiocruz de Pernambuco	Instituto de Medicina Integral Prof. Fernando Figueira - IMIP	https://ensaiosclinicos.gov.br/rg/RBR-10t3wc7z	<NULL>	Patients with a maximum age of 20 years; both genders; attended at reference services for the treatment of leukemia in Brazil with a clinical and cytological diagnosis of leucemia; who express the desire to participate in the project and the legal guardians sign the Free and Informed Consent Form and the children between 8 and 18 years old sign the Free and Informed Assent Term, providing clinical information, and allowing the analysis of samples (bone marrow) in the laboratory reference of the study in Recife	Patients with mature B-cell Leukaemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-5bq9jh3	Effects of group training in elderly women with knee osteoarthritis	Not yet recruiting	Intervention	2023-08-18	<NULL>	<NULL>	6362	Effects of group training on clinical and functional aspects in elderly women with knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5bq9jh3	<NULL>	Women; age between 60 and 80 years; diagnosis of osteoarthritis of the knee according to the criteria of the American College of Rheumatology; osteoarthritis of the medial femorotibial knee on radiography classified as grades 2 or 3 according to the Kellgren and Lawrence criteria (1957); mean knee pain score between 4.0 and 9.0 on the Numerical Pain Scale (NRS);	Body mass index greater than or equal to 30 kg/m2; cognitive deficits screened by the mini-mental state examination; being in current treatment with physiotherapy or doing regular physical exercise (more than twice a week) in the last 6 months; history of joint infiltration in the last 3 months or planning to receive infiltration in the next 6 months; history of knee or hip arthroplasty; history of knee surgery in the last 6 months or planning to undergo surgery in the next 6 months; presence of other illnesses that threaten safety or prevent participation in interventions or tests (symptomatic or severe coronary artery disease; dementia; use of walking aids; other types of arthritis such as rheumatoid arthritis); history of knee trauma in the last 30 days; inability to perform training protocol (inability to walk short distances or need assistance from another person to complete activities of daily living);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-9hyhm9c	Multicenter quasi-experimental clinical trial to evaluate the efficacy of pharmacotherapeutic intervention on clinical outcomes in liver failure	Not yet recruiting	Observational	2023-08-22	<NULL>	<NULL>	6372	Quasi-experimental pre-post-implementation, multicenter trial for evaluation of efficacy of pharmacotherapeutic interventions for the identification and reporting of drug-related problems in patients hospitalized for moderate and severe liver failure in improving outcomes Clinical	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Centro de Ciências de Saúde - UFRN	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-9hyhm9c	<NULL>	Age over 18 years; both sexes; hospitalized at Onofre Lopes University Hospital for chronic liver disease as the main diagnosis or as a comorbidity; clinical and laboratory signs of moderate or severe liver failure defined by Child-Pugh class B or C; signing of the Free and Informed Consent Form	Hospitalization for adverse reaction; discharge from hospital less than 3 months ago; hospitalization only for diagnostic procedure (e.g. liver biopsy) or procedure (e.g. esophageal variceal binding); patients transferred from another hospital or department; patients previously included in this study; diagnosis of metastatic liver, hepatocellular carcinoma, cholangiocarcinoma, sclerosing cholangitis, primary biliary cholangitis, hemochromatosis, Wilson&apos;s disease, zoonoses (echinococcosis, amebiasis, schistosomiasis, fasciolosis); acute hepatitis of viral, alcoholic, autoimmune, toxic, or gestational etiology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-7hmxnkm	Postoperative analgesia in gynecological laparoscopy: intraoperative methadone or magnesium sulfate	Not yet recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6377	Post-Laparoscopic gynecological analgesia: Methadone x Magnesium Sulfate. Randomized clinical trial	<NULL>	3, non-randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-09-01	Real e Benemérita Associação Portuguesa de Beneficência	Real e Benemérita Associação Portuguesa de Beneficência	https://ensaiosclinicos.gov.br/rg/RBR-7hmxnkm	<NULL>	Patients scheduled for medium-sized gynecological surgical laparoscopy (hysterectomy, oophorectomy, salpingectomy, endometriosis, without intestinal involvement, without inflammatory disease); who freely agree to sign the consent form and participate in the study	Cases that evolve with serious surgical complications (organ damage, hemorrhage, etc.); widening of the interval between the Q and T waves on the electrocardiogram; heart block other than first-degree atrioventricular block; renal failure; alteration in neuromuscular function; chronic pain in treatment with corticosteroids and/or opioids; allergy/contraindication to any of the study components	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-6xgzhpy	Effect of a period without and with smartphone use and continuous aerobic exercise on levels of anxiety and anger	Not yet recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6384	Comparison of the acute effect of a period without smartphone use with a period with smartphone use and continuous aerobic exercise on levels of state-anxiety and state-rage	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6xgzhpy	<NULL>	Age between 18 to 40 years; both genders; have your own cell phone with internet access	Contraindication for performing physical activity (PAR-Q); participants who are menstruating; pregnant participants; dysfunction (cardiac, endocrine, orthopedic and metabolic) that negatively influences the participants&apos; performance; anxiolytic treatment of any kind; and illiterate participants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-6fhv7x5	Analysis of clinical, humanistic and economic outcomes of patients with anxiety using herbal medicines	Not yet recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6387	Analysis of clinical, humanistic and economic outcomes of patients with anxiety using Passiflora sp.	<NULL>	4, n/a, n/a	4	<NULL>	<NULL>	<NULL>	2023-10-15	Universidade Federal de Alfenas- MG	Universidade Federal de Alfenas- MG	https://ensaiosclinicos.gov.br/rg/RBR-6fhv7x5	<NULL>	The study population will consist of people aged ≥ 18 years, without gender restriction, who sought pharmaceutical care at a university pharmacy with a main complaint of anxiety or symptoms that characterize anxiety.	Patients who do not adhere for any reason to the treatment with the proposed herbal medicine during the three months of follow-up in this study will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-3m5rqzh	Use of Repetitive Transcranial Magnetic Stimulation in the treatment of Dementia	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6391	Repetitive Transcranial Magnetic Stimulation in the adjunctive treatment of Neurodegenerative Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-03	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3m5rqzh	<NULL>	Diagnosis of dementia,Complementary imaging exam for the diagnosis of dementia;either Alzheimer&apos;s Dementia, Mixed,Frontotemporal Lobar Degeneration,Lewy bodies, among others;use of acetylcholinesterase inhibitors and or memantine in doses stable for at least 3 months;clinical dementia rating ≤ 2;the patient must be able to communicate,read and understand the term informed consent and be able to carry out assessments neuropsychological	Comorbidity with previously diagnosed psychiatric illness,contraindications to performing the neuromodulation method non-invasive like epilepsy,metal brain implants, non-removable metallic implants, cardioverter defibrillators,implantable devices, trauma or brain tumor;decompensated clinical disease like neoplasms, heart disease, pulmonary, hepatic, renal,and endocrine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-96yz64d	Evaluation of the clinical efficacy of Red Propolis-Modified Dental Cements	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6392	Evaluation of the clinical efficacy of Red Propolis-Modified Restorative Glass Ionomer Cements: a prospective randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-96yz64d	<NULL>	Patients who have vital teeth in need of deep class II restorations, evaluated clinically and radiographically, will be included in the study. They must be over 18 years old, free of systemic diseases and parafunctional habits	Exclusion criteria are: teeth with irreversible pulpitis or with indication for endodontic treatment; presence of abscess in antagonistic or adjacent teeth; teeth with periodontal and/or periapical pathologies; patients with extremely poor oral hygiene, xerostomia or with a history of allergies to the materials used; patients undergoing orthodontic treatment; pregnant or lactating patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-835555x	Effects of the consumption of Coffee with Cocoa and Cinnamon in the cardiovascular health	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6394	Cardiovascular effects of consumption of Coffee formulations enriched with Cocoa and Cinnamon: ECARDIO-CACACA study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-10	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-835555x	<NULL>	Be aged between 18-80 years; Mini-Mental State Examination ≥ 27 points; ≥ 22 points (person with 1-11 years of education) and ≥ 9 points (illiterate person); female patient; have telephone contact; Not allergic to products derived from cocoa, coffee and/or cinnamon; Have been diagnosed with high blood pressure for at least six months; Living in the health territory.	Being a chronic user of glucocorticoid and/or psychotropic drugs; Being a user of ≥ 3 different pharmacological classes of antihypertensive drugs; Being afflicted with diabetes; Being pregnant or breastfeeding; Being a woman with a history of osteoporosis; Having been submitted to some surgical treatment less than 30 days ago; be a smoker; Have severe kidney, liver, or cardiovascular problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-7twgjp6	Clinical evaluation of polymp active zinc to decrease dentinal hipersensibility	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6397	Clinical evaluation of polymp active (Zn) to decrease dentinal hipersensibility	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Andres Felipe felipe Millan Cardenas	Centro Universitário de Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-7twgjp6	<NULL>	Good oral and general health; be at least 18 years of age; probing depth less than 3 millimeters, dentin sensitivity; have at least 2 teeth and a maximum of 4 teeth with non-carious cervical lesions	Patients with advanced periodontal disease; severe or chronic periodontitis; bruxism; Pregnant or lactating participants; participants in chronic use of anti-inflammatory, analgesic or psychotropic drugs, patients with dental fractures, or with unsatisfactory restorations or deep caries or who use fixed, removable or total partial dentures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8zvwkv8	Genial Care model: treatment for children with autism spectrum disorder	Not yet recruiting	Observational	2023-09-04	<NULL>	<NULL>	6404	Genial Care model: intervention for children with autism spectrum disorder	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo PUCSP campus Sorocaba	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo PUCSP campus Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-8zvwkv8	<NULL>	Children aged between zero and five years; children of both genders; children belonging to any social group, skin color, race, or ethnics; children diagnosed with autism spectrum disorder; children that are not being submitted to a similar intervention protocol; children whose guardian is available for conducting the child to the Genial Care clinic or partner clinic; children whose guardian is available for participating in parental guidance; children whose guardian has access to the Internet	Children that are being submitted to a similar intervention protocol; children aged over five years; children whose guardian is not available for conducting the child to the Genial Care clinic or partner clinic; children whose guardian is not available for participating in parental guidance; children whose guardian does not have access to the Internet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-6t6grh7	Effect of an ankle-focused Global Exercise program on static posture balance, task stability, and functionality in individuals with Ankle Instability	Not yet recruiting	Intervention	2023-09-05	<NULL>	<NULL>	6408	Effect of a Global Rehabilitation program with local emphasis on static postural control, stability, dynamics and functionality in individuals with lateral ankle Instability - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-30	Escola de educação física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de educação física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6t6grh7	<NULL>	The sample of this study will be for convenience and will consist of individuals of both sexes; aged between 18-45 years; body mass index less than 30 kg/m²; with no history of other injuries in the lower limbs; without acute ankle sprains ( minimum three months prior to the collection); who do not participate in other rehabilitation programs; and who report the presence of the following criteria: having a history of at least one ankle sprain associated with pain requiring a change in gait pattern; avoiding weight bearing on the foot affected for at least one day; present a feeling of weakness, pain or instability that appeared after the traumatic ankle event; present a score less than or equal to 24 on the Cumberland Ankle Instability Tool	Individuals who are unable to attend the reassessments (cannot be contacted or have an injury that prevents the proposed tests from being carried out) and who initiate some other type of treatment after the start of the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8dwf73m	Prevention of Eating Disorders	Not yet recruiting	Intervention	2023-09-06	<NULL>	<NULL>	6410	Prevention of Eating Disorders	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade de Franca	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-8dwf73m	<NULL>	Female adolescents from public schools in a city in the interior of São Paulo who voluntarily agreed to participate in the study; aged between 11 and 14 years; who are not pregnant; who did not have a diagnosis of psychiatric illness - except for eating disorders; who are unable to hear or communicate.	The exclusion criteria adopted for the groups will be: adolescents in a situation of pregnancy; who did not present the minimum conditions necessary to perform the task in a group, both in cognitive terms (indication of lowering in the intellectual level, evaluated empirically), and clinically (presence of severe organic or psychiatric disease - in the latter case, except for the diagnosis of AN in the RG), or even hearing or communication impairment that made it impossible to carry out the group interview	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-5cbvq6p	Evaluation of the Allergy potential of a Cosmetic Product (HRIPT+Phototest)	Not yet recruiting	Intervention	2023-09-12	<NULL>	<NULL>	6424	EN22-0674-01_02_Allergenic evaluation for Cosmetic Product (HRIPT+Phototest)	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-13	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-5cbvq6p	<NULL>	Participants of both sexes aged 18 to 70 years; intact skin in the region of application; agreement to follow trial procedures and to report to the clinic on designated days and times for medical assessments and application and reading of pads; understanding, consent and signature of the Free and Informed Consent Term (TCLE); phototype: I, II, III and IV (for the phototest test, only phototypes II and III will be considered)	For the HRIPT trial and phototest: Participants who have been diagnosed with COVID 19 within the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; pregnancy or risk of pregnancy and/or lactation (when women); use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the evaluation or during the study period; anticipated intense exposure to sunlight or tanning sessions during the study period; prediction of sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; scheduled vaccination during the study period or up to 03 weeks before selection; history of sensitization, irritation, or photosensitivity to topical products; active skin pathologies (local and/or disseminated) that may interfere with the study results; skin reactivity; use of new drugs/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; history of known or suspected intolerance to any ingredient of the study products (test or comparative product); history of non-compliance or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study. If yes, it should be described in observation in the clinical record. Only for the phototest test: previous history of pathologies aggravated or triggered by ultraviolet radiation; use of photosensitizing drugs; history or activity of photodermatoses; personal or family history of skin cancer; presence of precursor lesions of skin cancer, such as melanocytic nevi and actinic keratoses; use of new drugs/cosmetics during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-7jc7btr	Assessment of skin irritability after using a health product responsible for reinforcing the skin&apos;s protection barrier, preventing microorganisms that cause skin diseases	Not yet recruiting	Intervention	2023-06-22	<NULL>	<NULL>	6428	Assessment of primary dermal irritability, cumulative dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-09	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7jc7btr	<NULL>	Participants of both sexes aged 18 to 70* years; Phototype: I, II, III and IV (according to an adapted scale); Skin of the application region is intact; Agreeing to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for applying and reading swabs; Understanding, consent and signature of the Free and Informed Consent Term	Participants who have been diagnosed with COVID 19 in the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; Pregnancy or risk of pregnancy and/or lactation (when women); Use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; Immunosuppression by drugs or active diseases; Decompensated endocrinopathies; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; Expect intense exposure to sunlight or tanning sessions during the study period; Provision of bathing in the sea, swimming pool or sauna during the study; Practice of water sports during the study; Dermographism; Use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; Aesthetic and/or dermatological treatment on the body within 03 weeks prior to selection; Scheduled vaccination during the study period or up to 03 weeks before selection; History of sensitization, irritation or photosensitivity to topical products; Active skin pathologies (local and/or disseminated) that may interfere with the study results; Skin reactivity; Use of new drugs/cosmetics during the study; Previous participation in studies with the same product; Congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; History of known or suspected intolerance to any ingredient of the study product (test or comparative product); History of non-adherence or unwillingness to adhere to the study protocol; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; Other conditions considered by the researcher as reasonable for disqualification from participation in the study. If yes, it should be described in observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-8bbz36g	Supervised versus Minimally Supervised Exercises in the Treatment of Chronic Neck Pain	Not yet recruiting	Intervention	2023-09-14	<NULL>	<NULL>	6434	Supervised versus Minimally Supervised Exercises in the Treatment of Non-Specific Chronic Neck Pain: Randomized and Blinded Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-10	Departamento de Fisioterapia da UFRN	Departamento de Fisioterapia da UFRN	https://ensaiosclinicos.gov.br/rg/RBR-8bbz36g	<NULL>	Individuals of both sexes; age between 18-50 years; present a primary complaint of non-specific neck pain (equivalent to classification grades I and II according to the Neck Pain Task Force)(5), present pain for 12 weeks or more; presenting pain equal to or greater than 3 on the END (numerical pain scale 0-10); understand, tolerate and monitor assessment and intervention procedures; not having performed previous surgery of the cervical spine.	Subjects who have blood clotting disorders, diffuse idiopathic skeletal hyperostosis (DISH), significant infectious disease, or other serious disabling health conditions; Pregnant or breastfeeding women; or having received treatment in the past 2 months for neck pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-9hvrmz8	Immediate placement delayed loading of a patient specific dental Implant; an essential experimental device exemption study	Not yet recruiting	Intervention	2023-09-15	<NULL>	<NULL>	6437	Immediate placement delayed loading of a patient specific one piece cad/cam designed dental implant: a pivotal ide study	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade de São Paulo - Faculdade de Odontologia	Atlantis Clinical Brazil LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9hvrmz8	<NULL>	Subjects 22 to 75 years of age. Both sexes. Subject indicated for single-rooted tooth or fused premolar roots atraumatic extraction with the intention for immediate implant placement that does not require bone augmentation (i.e., no lateral, vertical, or sinus augmentation required), the implant restoration will support a single-unit prosthetic restoration. Proposed implant sites should have intact cortical plates (at least 1 mm in thickness) and free of apical lesions or marginal bone loss. Implant sites with sufficient soft tissue quality, quantity, and morphology that do not require augmentation (thick phenotype). Subjects will have read, understood, and signed an institutional review board approved Informed Consent Form. Subjects must be able and willing to follow study procedures and instructions	Subjects with a history of tobacco use within the last two years. Subjects with healing disorders (such as: diabetes mellitus confirmed HgA1C of &gt; 7 within six months prior to screening, cancer, HIV, bone metabolic diseases or Type IV heart disease) that could compromise wound healing and/or preclude implant surgery; or who are currently receiving, or have received within two months prior to study entry, systemic corticosteroids, immunosuppressive agents, radiation therapy, and/or chemotherapy which could compromise wound healing and/or preclude oral surgery. Subjects taking any bisphosphonates; Subjects taking hormone therapy or have had a hysterectomy. Female subjects who are pregnant or lactating, or who intend to become pregnant during the study duration. Subjects participating in other clinical studies involving therapeutic intervention (either medical or dental). Subjects with proposed implant sites that demonstrate soft tissue recession or soft tissue deficiency that requires soft tissue augmentation. Subjects with untreated periodontal disease or other uncontrolled infections of the oral cavity. Subjects who have a bruxing or clenching habit. Subjects with insufficient oral hygiene (plaque score &gt; 25%, bleeding on probing &gt; 50% of sites). Subjects, who in the opinion of the investigator, for any reason other than those listed above, will not be able to complete the study per protocol. Subjects with cuspid protected occlusion, where full disclusion of all working side posterior teeth occurs in lateral movements. Subjects with other implant treatments currently in progress or who require replacement of additional teeth within the time frame of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-10wr9c7d	Interventions to support the Recovery after Muscle Exhaustion	Not yet recruiting	Intervention	2023-09-15	<NULL>	<NULL>	6438	Interventions for Physical Recovery after Muscle Fatigue	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-25	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10wr9c7d	<NULL>	College athletes of any sport; of both genders; over 18 years old; to train at least three times a week at a competitive level	Interruption of sports activities in the last six months due to injuries; report of any neurological, musculoskeletal, cardiovascular, pulmonary or metabolic condition that may interfere or contraindicate the research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-273z6gj	Pain sensation, hypervigilance and oral habits in individuals with Painful Temporomandibular Disorders and Tinnitus	Not yet recruiting	Observational	2023-09-17	<NULL>	<NULL>	6439	Pain Threshold, hypervigilance and oral behaviors in individuals with Painful Temporomandibular Disorder and Somatosensory Tinnitus	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-273z6gj	<NULL>	Volunteer individuals; both sexes; between 18 and 60 years old; diagnosed with painful temporomandibular disorder, defined by the Diagnostic Criteria for Temporomandibular Disorders and somatosensory tinnitus	Participants who do not agree to participate in the study; who have some cognitive difficulty that prevents them from answering the questionnaires; under 18 years old; with degenerative neurological diseases; history of psychiatric hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-3hv3hhs	Training on postpartum depression for nurses working in health centers	Not yet recruiting	Intervention	2023-09-17	<NULL>	<NULL>	6440	Continuing Education on Postpartum Depression for primary health care nurses: a quasi-experimental study	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-3hv3hhs	<NULL>	The study will be carried out with 96 participants; aged over 18; nurses who work in the Primary Health Care network and provide care to puerperal women	Nurses who do not provide nursing care to the puerperal woman; those who are on vacation or away from their work activities during the data collection period; or for some other reason that makes it impossible for them to participate; and those who fail to participate in any of the permanent health education meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-8m3htgm	Evaluation of the Activity of Supraphysiological Testosterone Doses in the Fall of PSA in Patients with Prostate Cancer Unresponsive to the lack of Testosterone and without Metastases	Not yet recruiting	Intervention	2023-09-17	<NULL>	<NULL>	6442	Evaluation of supraphysiological doses of Testosterone in patients with castration-resistant prostate Adenocarcinoma without metastases	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-28	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8m3htgm	<NULL>	Patients between 18 and 75 years old; diagnosis of prostate adenocarcinoma without neuroendocrine differentiation or unconventional subtypes; resistant to surgical or medical castration; not metastatic; PSA doubling time &lt; 10 months	Patients with PS &gt; 2; Presence of moderate to severe organic dysfunctions related, among others, to liver, kidney or heart function; Uncontrolled primary prostatic disease; Presence of previous or current diagnosis of another neoplasm except non-melanoma skin cancer; Positive pelvic node disease, considered as any pelvic lymph node larger than 2.0 cm in the shortest axis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-2v4qz72	Study of the effects of biperiden in the treatment of alcoholism	Not yet recruiting	Intervention	2023-09-18	<NULL>	<NULL>	6445	Effects of biperiden in the treatment of alcohol use disorder: a randomized, double-blind, placebo-controlled trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-09-28	Escola Paulista de Medicina - Universidade Federal de São Paulo	Escola Paulista de Medicina - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2v4qz72	<NULL>	Patients with alcohol dependence, according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition; age between 18 and 50 years old; male; literate the ability to write and read in Portuguese	Present other serious psychiatric disorders, such as schizophrenia and bipolar mood disorder; present severe dependence criteria for other drugs, except tobacco; have severe cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-8nwxhs4	Test validation for HRD detection using NGS methodology	Not yet recruiting	Observational	2023-09-18	<NULL>	<NULL>	6446	Homologous recombination deficiency (HRD) test validation by NGS methodology at Oncoclínicas Precision Medicine laboratory in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Oncoclinicas do Brasil Serviços Médicos S.A	LOCUS - Anatomia Patologia e Citologia LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8nwxhs4	<NULL>	Patients &gt; 18 years old; diagnosed with high grade serous ovarian cancer; platinum-sensitive; mutant or wild type for germline or somatic HRR genes based on OCPM Next Generation Sequencing (NGS) panels.	Patient that do not accept to sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-2fs9kms	Development of a mobile application and the effectiveness of a brief asynchronous mindfulness and self-compassion intervention for cases of Anxiety, Stress and Depression	Not yet recruiting	Intervention	2023-09-18	<NULL>	<NULL>	6447	Development of a mobile application and the effectiveness of a brief asynchronous mindfulness and self-compassion intervention for cases of Anxiety, Stress and Depression in university students and teachers of basic education: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Centro de Ciências Humanas, Letras e Artes - Universidade Federal da Paraíba	Centro de Ciências Humanas, Letras e Artes - Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2fs9kms	<NULL>	Study 1: be between the ages of 18 and 65; both genders; be Brazilian; being a basic education teacher; have internet access and a cell phone with Android system; be willing to download and use the application; achieving a score greater than 0 on symptoms of depression, anxiety, and stress measured by subscales of the Depression, Anxiety, and Stress Scale (DASS-21) (Vignola &amp; Tucci, 2014). Study 2: be between the ages of 18 and 35; both genders; be Brazilian; be a university student (undergraduate or graduate); have internet access and a cell phone with Android system; be willing to download and use the application; achieving a score greater than 0 on symptoms of depression, anxiety, and stress measured by subscales of the Depression, Anxiety, and Stress Scale (DASS-21) (Vignola &amp; Tucci, 2014)	Studies 1 and 2: already adopting a frequent mindfulness practice in the last 6 months; be using some type of psychotropic medication; being under psychological treatment; have a diagnosis of psychiatric or neurological illness (eg, schizophrenia, borderline personality disorder); not have or be willing to create a Gmail account	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-6j4kw7q	Evaluation of analgesia provided by the use of Morphine or Methadone in women undergoing Laparoscopic Surgery	Not yet recruiting	Intervention	2023-09-20	<NULL>	<NULL>	6455	Morphine versus Methadone as postoperative analgesia in women undergoing Laparoscopic Surgery: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-6j4kw7q	<NULL>	Women undergoing clinical follow-up for gynecological pathologies at the Center for Integral Attention to Women&apos;s Health -  CAISM; 18 years or older, regardless of ethnicity or race; elective surgeries; laparoscopic surgery	Patients who have chronic pain; patients who are regularly using opioids; patients using illicit drugs; patients diagnosed with dementia; patients who do not understand the Portuguese language; patients with allergy to local anesthetics or to all non-steroidal anti-inflammatory drugs (ketoprofen, tenoxicam, diclofenac, dipyrone, paracetamol)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-6yqjpv6	Blood flow restriction mobilization for prevention of acquired weakness	Not yet recruiting	Intervention	2023-09-21	<NULL>	<NULL>	6458	Kinesiological Ultrasonography analysis of early active and passive mobilization with blood flow restriction in the prevention of acquired weakness in patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-14	Universidade Estadual do Piauí - UESPI	Universidade Estadual do Piauí - UESPI	https://ensaiosclinicos.gov.br/rg/RBR-6yqjpv6	<NULL>	Adults over 18 years old.  Both genders. Hospitalization for more than 24 hours in the ICU ward. The stay must be at least 72 hours	Neuromuscular pathology. Osteoarticular contraindication to mobilization. Amputees. Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-38trvv9	Evaluation of maxilla, mandible and nose size among participants with Cleft Lip compared to participants without Cleft Lip	Not yet recruiting	Intervention	2023-09-26	<NULL>	<NULL>	6462	Evaluation of the maxillomandibular and nasal proportion of participants with Cleft Lip and Palate compared to normotypical participants	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Hospital da Baleia	https://ensaiosclinicos.gov.br/rg/RBR-38trvv9	<NULL>	Non-syndromic individuals with unilateral or bilateral cleft lip and palate; individuals born up to 3 weeks old (control and to be treated with NAM); individuals aged up to 2 years (groups not treated with NAM – pre and post surgical follow-up); male and female babies individuals with no cleft lip and palate (control group); individuals without a medical history of recurrent middle ear otitis; individuals whose parents and/or guardians agree to participate in the study and sign the TCLE; individuals whose parents or guardians are of legal age	Cleft individuals with other systemic diseases; participants with incomplete cleft lip and palate; individuals who have already undergone palate repair surgery; individuals using topical or systemic antibiotics or corticosteroids, individuals whose parents or guardians are minors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-2n2nfp6	Acrylic splints for treating chronic muscle pain in patients with TMD: randomized clinical trial	Not yet recruiting	Intervention	2023-09-28	<NULL>	<NULL>	6467	Total and partial splints in the treatment of chronic myalgia in patients with TMD: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-2n2nfp6	<NULL>	Having myalgias related to Temporomandibular Disorders (TMDs) for longer than 6 months; myalgias located in the temporal region accompanied, or not, by other facial myalgias; be aged 18 years or over; both genders; pain on palpation with a score greater than or equal to 7 on the numeric rating scale; pain related to functional and/or parafunctional activities of the stomatognathic system	Patient undergoing physiotherapeutic and/or speech therapy treatments that have repercussions on muscle, joint and/or skeletal structures in the head and neck region; who have undergone some type of temporomandibular joint procedure in the last 12 months; patients with facial paralysis; patients undergoing orthodontic treatment; complete denture users; who underwent a procedure using botulinum toxin in the head and neck region in the last 6 months; patients using Selective Serotonin Reuptake Inhibitors (SSRI) antidepressants; patients undergoing psychological treatment; patients who have cognitive and/or neuromotor difficulties that compromise the stages of the study&apos;s development	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-75v8pxk	Effectiveness of an Eye Patch for preventing Corneal Injury in intensive care unit patients: an interventional study	Not yet recruiting	Intervention	2023-09-29	<NULL>	<NULL>	6469	Effectiveness of a Polyethylene Chamber for the prevention of Corneal Injury in sedated and mechanically ventilated patients: a randomized clinical trial	<NULL>	array, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-06	Universidade Federal do Acre- UFAC	Universidade Federal do Acre- UFAC	https://ensaiosclinicos.gov.br/rg/RBR-75v8pxk	<NULL>	Adult and elderly patientssedated and on mechanical ventilation from the Intensive Care Unit	Patients hospitalized for less than 48 hours or with corneal injury on admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-10xv7t6b	Skin cleansing soap with Candida auris: clinical trial to evaluate safety and efficacy	Not yet recruiting	Intervention	2023-10-01	<NULL>	<NULL>	6474	Cutaneous antiseptic for Candida auris decolonization: randomized double-blind clinical trial to evaluate safety and efficacy	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-12-01	Centro de Ciências Médicas da Universidade Federal de Pernambuco	Hospital da Restauração de Pernambuco Governador Paulo Guerra	https://ensaiosclinicos.gov.br/rg/RBR-10xv7t6b	<NULL>	Patients hospitalized in the Intensive Care Units of the Hospital da Restauração who have skin colonization with Candida auris confirmed by the hospital&apos;s clinical analysis laboratory, aged 18 years or older, without limitation of gender and race and who have signed the Term of Free and Informed Consent - TCLE	Patients with a previous diagnosis of superficial or invasive mycosis and who are using antifungal therapies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-73v6sqk	Social Skills Training and psychological distress in health students	Not yet recruiting	Intervention	2023-10-03	<NULL>	<NULL>	6479	Social Skills Training and psychological distress in health students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Juiz de Fora - UFJF	Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-73v6sqk	<NULL>	Students of the research target courses who present complaints related to difficulties in interpersonal relationships and symptoms of psychological distress. Minumim age 18 years. Both genders. Students who have or have not responded to the assessment protocol in the first study proposed in this project may participate. Indication of the need to participate in a Social Skills Training program (according to the score obtained in the Del-Prette Social Skills Inventory - IHS2-Del-Prette). Clinical indices of depression, generalized anxiety and/or social anxiety, according to the score obtained on the instruments used for such assessment	Those students who at the time of the pre-test are undergoing psychological and/or psychiatric treatment will not be included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-3mcdzwg	Effect of practicing Auriculotherapy on tremors and motor symptoms in elderly people with Parkinson&apos;s disease: a case-control study	Not yet recruiting	Intervention	2023-10-04	<NULL>	<NULL>	6483	Effect of Auriculotherapy on the motor symptoms of elderly people with Parkinson&apos;s: Case-control study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade do Estado do Rio Grande do Norte	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3mcdzwg	<NULL>	Individuals over 60 years of age; of both sexes; with a diagnosis of Parkinson&apos;s disease with medical report by a neurologist, in regular outpatient follow-up; absence of other neurological disorders or comorbidities that could affect gait; absence of dementia; vision and hearing adequate or corrected to normality; be available to participate in activities and time availability for submission to intervention sessions	Individuals with uncompensated morbidities; having physical problems and/or impairments that could be aggravated during the intervention, such as a history of vestibular disease, psychiatric disorders, unilateral or bilateral hearing deficit; having a cognitive disorder; severe change in visual acuity and/or history of stroke; who have an infection, inflammation or injury to the ear; make use of piercing (except normal earring); refusal to receive auricular treatment using mustard seeds; not responding to three contact attempts made by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10vpf9bm	Telehealth Intervention to improve Heart Failure care after hospital discharge	Not yet recruiting	Intervention	2023-10-03	<NULL>	<NULL>	6484	Digital Optimization Toolkit for management of Heart Failure after discharge	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-23	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-10vpf9bm	<NULL>	Age &gt;18 years; diagnosis of heart failure (HF) with left ventricular ejection fraction (LVEF) ≤50%, from Echocardiogram, Cardiac Magnetic Resonance Imaging or Myocardial Scintigraphy; hospitalization for HF with discharge scheduled for the next few days or recent hospitalization for HF with discharge less than 2 weeks ago; at least one medication of the conventional treatment (betablockers, ACEI/ARB/ARNI, MRA) not started or two medications among those with a prescribed dosage less than or equal to 50% of the target dose; and who agree to participate and sign the Informed Consent Form	CKD (chronic kidney disease) stage V; Previous heart transplant or active patient on the heart transplant list; Previous use of Ventricular assist device; Cardiac amyloidosis; Pregnant or planning to become pregnant; Estimated life expectancy of less than 6 months related to non-cardiac comorbidities according to the investigator&apos;s judgment; Defined as for palliative support; Current participation in another study to investigate devices or drugs, or have participated in another study in the last 30 days; Patient or caregiver who lives in the same household without access to Smartphone; Patient without cognitive conditions to make own decisions; Illiterate patients (do not know how to read and/or write) without a responsible caregiver; patient who for some reason will not be available to complete the procedures (eg interviews) established in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-9ycg67p	Laser to control Anxiety during Third Molar Extraction	Not yet recruiting	Intervention	2023-10-05	<NULL>	<NULL>	6485	Intravascular Laser Irradiation of Blood (ILIB) to control Anxiety in patients undergoing Lower Third Molar Extraction: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade Evangélica de Goiás	Universidade Evangélica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9ycg67p	<NULL>	Patients who agree to participate in the study and sign the free and informed consent form; older than 18 years; both genders; ASA classification I or II (American Society of Anesthesiologists, 2023), who have not previously undergone third molar extraction; indication of extraction of at least one lower third molar, with a moderate or minimally difficult level according to Pederson&apos;s classification	Patients with signs of infection or inflammation in the tissues adjacent to the teeth indicated for extraction; with psychiatric disorders; cognitive distortions that interfere with the application of the questionnaire; patients using anxiolytics or antidepressants; pregnant women; patients who do not have at least one radial artery available for Intravascular Laser Blood Irradiation (ILIB) therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-5k9fz6d	Palliative care: competencies among medicine students in Brazil	Not yet recruiting	Observational	2023-10-09	<NULL>	<NULL>	6490	Palliative Care: Competencies among medicine students in Brazil, a Cross-Sectional Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5k9fz6d	<NULL>	All students regularly enrolled in the medical course in Brazil and of legal age who wish to participate in the research will be invited and included.	Minors and those who present some limitation to answer questionnaires will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-6yp5vsr	Increased index finger strength induced by a overflow of strength from the contralateral shoulder musculature	Not yet recruiting	Intervention	2023-10-10	<NULL>	<NULL>	6497	Increase in index finger flexion strength induced by overflow contralateral to isometric contraction of the shoulder abductor muscle	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-06	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Centro Universitário Padre Albino	https://ensaiosclinicos.gov.br/rg/RBR-6yp5vsr	<NULL>	Both sexes; age group from 18 to 30 years old; motor preference for the right upper limb	Presenting any orthopedic alteration or pain that hinders the execution of the movement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-655vxdd	Effect of Strength, Aerobic and Concurrent Training on memory, musculature and intestinal health in the elderly	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6498	Effect of Strength, Aerobic and Concurrent Training on cognitive, neuromuscular parameters and the microbiota-intestine-brain axis in elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-655vxdd	<NULL>	Age over 60 years. Elderly men and women. Body mass index below 30. Present physical conditions to carry out the exercise protocol. Have not been performing any regular physical activity for at least three months. Without a history of practice competitive sports throughout life. Achieve a score equal to or greater than 24 on the Mini-Mental State Examination. Achieve a score of up to 9.11 on the Baecke Physical Activity Questionnaire, the cut-off point adopted for low intensity of daily physical activity	"Use of antidepressants, antiepileptics, anticonvulsants, psychoactive drugs or other medications that act on the Nervous System. In use of antimicrobials for 30 days. In use of chemotherapy/immunotherapeutics
In use of probiotics. In use of metformin and or proton pump inhibitor. On enteral diet. Recently hospitalized for 30 days. Acute or chronic bowel conditions (diarrhea, inflammatory bowel disease, Irritable Bowel Syndrome). Bariatric disease. Chronic diseases (diabetes). Cancer. Rheumatological diseases. Neurodegenerative diseases. Autoimmune diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-4msk3yg	Effect of Fludroxycortide and Imiquimod creams in the treatment of lip lesions resulting from chronic sun exposure	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6499	Effect of Fludroxicortide and Imiquimod creams on the treatment of Actinic Cheilitis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-05	Fernanda Gonçalves Salum	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4msk3yg	<NULL>	Patients with actinic cheilosis classified as grades III or IV as previously described; Over the age of 30 years; White skinned	The presence of other lesions in lip vermilion in addition to solar cheilitis; Immunosuppression such as transplanted or infected with HIV patients; Any type of treatment for actinic cheilosis in the last six months (except with sunscreen and lip balms; Known allergy to imiquimod or fludroxycortide; Pregnancy or breastfeeding; Histopathological diagnosis of carcinoma in situ or invasive squamous cell carcinoma; History of radiotherapy in the head and neck region; Any condition that may compromise the collaboration in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-5vktsgj	Multicomponent Exercises and their relationship with Intrinsic Capacity and Frailty	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6500	Intrinsic Capacity and Frailty: an intervention with Multicomponent Exercises based on the integrated care for the elderly – Icope of the World Health Organization	<NULL>	0, randomized-controlled, triple-blind	0	<NULL>	<NULL>	<NULL>	2023-10-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5vktsgj	<NULL>	Persons aged 60 years or older; Both sexes; Enrolled in the School Health Center; Under elective follow-up with the health team at the study site; Living at home; Which presents the impaired mobility domain in the intrinsic capacity screening; Have access to a mobile phone with internet to participate in the proposed intervention; Who has a family member and/or caregiver to accompany/supervise the performance of the exercises	Inability to perform the Short Physical Performance Battery test; Insanity; Severe hearing or visual impairment; Illness causing severe functional limitation (Barthel less than 20); Permanent or temporary inability to walk; Amputation of limbs; Aphasia and loss of strength caused by a stroke; Hospital admission in the last three months for any reason; Diagnosis of cancer with active chemotherapy or radiotherapy treatment; Score less than &lt; 20 points on the Mini Mental State Examination (MMSE); Performing physical exercises in daily life.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-86rj26s	The effect of physiotherapeutic assistance on the first delivery of high-risk pregnant women: a randomized clinical trial	Not yet recruiting	Intervention	2023-06-23	<NULL>	<NULL>	6504	Effectiveness of phisiotherapy assistance in the induced labor of high-risk primiparous: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-30	Departamento de Fisioterapia - Universidade Federal de Pernambuco	Centro de Parto Normal e Alojamento Conjunto - Hospital da Mulher do Recife	https://ensaiosclinicos.gov.br/rg/RBR-86rj26s	<NULL>	Primiparous women; labor induction with misoprostol 25mcg, vaginally; gestational age between 37 and 42 weeks, confirmed by the date of the last menses and/or by the most recent obstetric ultrasound; presence of a single, live fetus with cephalic presentation	Women with difficulty understanding verbal commands; identification of obstetric factors during hospitalization that suggest failure of induction or indication for cesarean section: fetal cardiotocography not tranquilizer/acute fetal distress, severe pre-eclampsia with blood pressure spikes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-8fqyxjc	Immediate effects of the Hook on Pain and Mouth Opening after Fitting Dental Appliances	Not yet recruiting	Intervention	2023-10-13	<NULL>	<NULL>	6506	Immediate effects of Diacutaneous Fibrolysis on Pain assessment and Mouth Opening after Orthodontic Appliance Placement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-16	Instituto de Saúde e Biotecnologia	Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-8fqyxjc	<NULL>	Volunteers starting orthodontic treatment aged between 12 and 45 years; accepting and signing the conditions of the study in accordance with the Informed Consent Form and Assent Form; good general health; absence of caries lesions or periodontal diseases	Use of analgesic or anti-inflammatory medication; fibromyalgia sufferers; volunteers with Temporomandibular Disorder and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10mxzptc	Effects of knee clicking on thigh muscles and walking in people with and without knee pain	Not yet recruiting	Observational	2023-10-18	<NULL>	<NULL>	6517	Repercussions of knee crepitus on objective aspects of the muscle and locomotor functions of people with and without Patellofemoral Pain: main project	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10mxzptc	<NULL>	Both genders; aged between 18 and 35 years; unilateral pain in the anterior, retro, or peripatellar region; insidious pain present for at least 3 months; self-reported pain intensity greater than 3 when quantifying the worst pain experienced in the knee in the week prior to screening, using a numerical scale ranging from 0 to 10; a score lower than 83 on the Anterior Knee Pain Score (AKPS) questionnaire	Bilateral knee pain complaints; history of surgery in any lower limb joint; history of patellar subluxation or dislocation; clinical evidence of meniscal injury; ligamentous instability; patellar tendinopathy; osteoarthritis in any lower limb joint; the presence of referred pain originating from the spine or any musculoskeletal condition more severe than patellofemoral pain; neurological disease; previous treatment for patellofemoral pain in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-2h3tz6f	Exercise protocols to prevent Muscle Loss after Bariatric Surgery and improve Sleep-Disordered Breathing	Not yet recruiting	Intervention	2023-10-20	<NULL>	<NULL>	6525	Analysis and control of muscle Mass Loss After Bariatric Surgery and possible implications for Sleep-Disordered Breathing: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Faculdade de Ciencias Medicas de Minas Gerais	Instituto Bariátrico	https://ensaiosclinicos.gov.br/rg/RBR-2h3tz6f	<NULL>	Participants aged between 18 and 65 years; of both genders; who seek the Bariatric Institute to undergo bariatric surgery;  will be operated on by disabsorptive, restrictive techniques or a combination of both	Participants who have surgical complications after hospital discharge; participants who do not show satisfactory adherence to the proposed exercise programs; participants who have a clinical condition that precludes the prescription of physical activity in the postoperative period of bariatric surgery;  participants who need a new intervention surgery during the study period; participants who declare themselves pregnant during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-2typh66	Effects of two types of associated brain stimulation to improve unilateral spatial neglect after stroke	Not yet recruiting	Intervention	2023-10-24	<NULL>	<NULL>	6533	Effect of Transcranial Magnetic Stimulation by Theta Burst Modality as a Priming Effect to Transcranial Direct Current Stimulation in Unilateral Spatial Neglect after Stroke: TITAN TRIAL	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Departamento de Clinica Médica	Departamento de Clinica Médica	https://ensaiosclinicos.gov.br/rg/RBR-2typh66	<NULL>	Individuals of both sexes, aged 18 to 85 years, with a diagnosis of ischemic stroke in the subacute phase (7 days to 3 months from the onset of symptoms, due to lesions of the right virus, confirmed by tomography CT and or magnetic resonance imaging (MRI) and unilateral spatial neglect diagnosed by checking less than 129 on the Behavior Intention Test - BIT	Individuals with any metal in the head segment, skin lesions in the electrode placement area, clinical instability, severe cognitive impairment, global aphasia, visual disturbances prior to stroke, hemorrhagic stroke, previous Rankin bigger then 1, bilateral lesions, pacemaker, epilepsy, severe CHF or unstable conditions that may pose a risk to the participant, concurrent diagnosis of rapidly deteriorating illness (eg, terminal cancer), participating in studies involving medications or other interventions, pregnancy, or other associated neurological conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-4pzsfxw	Effects of adding Gait Retraining to lower limb muscle Strengthening on clinical, functional and kinematic parameters of individuals with knee Arthrosis	Not yet recruiting	Intervention	2023-09-08	<NULL>	<NULL>	6534	Effects of adding Gait Retraining to Lower Limb Muscle Strengthening on clinical, functional and kinematic parameters of individuals with knee Osteoarthritis: a double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-18	Universidade Federal de Juiz de Fora	Programa de Pós-Graduação em Ciências da Reabilitação e Desempenho Físico-Funcional da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4pzsfxw	<NULL>	Reliability test participants: students from the Federal University of Juiz de Fora; age equal to or greater than 18 years; no inflammatory, autoimmune, infectious, or traumatic arthropathies; no history of surgery of any joint of the lower limbs; did not use intra-articular injections in the last 6 months. Participants in the intervention or control groups: individuals aged 50 to 65 years; clinical diagnosis of unilateral and bilateral knee osteoarthritis according to the criteria of the American College of Rheumatology; radiographic severity grade II and III according to Kellgren and Lawrence criteria; able to walk freely for at least 10 minutes without needing an assistive device; no inflammatory, autoimmune, infectious, or traumatic arthropathies; no history of arthroplasty or any other surgery of any joint of the lower limbs; who did not use intra-articular injections in the last 6 months; body mass index less than 30 kg/m2; lack of diagnosis of neurological diseases, whether central or peripheral, and vascular diseases of the lower limbs; controlled blood pressure levels, with resting systemic blood pressure below 160/110 mmHg	Participants who do not have the minimum score on the Mini Mental State Examination test; participants who perform intra-articular or surgical infiltration procedures during the application of the research protocol; those who present cardiovascular decompensations, given by pressure levels higher than 220/105 mmHg during the execution of the exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2kk9vnh	The cognitive and motor effects of Immersive Virtual Reality in patients with Cognitive Impairment	Not yet recruiting	Intervention	2023-10-25	<NULL>	<NULL>	6536	Cognitive and motor effects of Immersive Virtual Reality in patients with Neurocognitive Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2kk9vnh	<NULL>	Will be included (1) elderly patients (&gt;60 years old); (2) of both genders; (3) with adequate command of the Portuguese language; that are classified into one of the following two categories: (3) Mild Neurocognitive Disorder – at least one domain with composite score less than or equal to – 1, but without criteria for dementia; (4) Mild Major Neurocognitive Disorder with CDR less than 2 and (5) accepting to participate in the study by signing the Informed Consent Form.	Individuals with (1) previous diagnosis of major neurocognitive disorder with CDR greater than or equal to 2 will be excluded; (2) presence of delirium, psychotic mental disorders, or substance-related mental disorders according to DSM-5 criteria; (3) severe retinal problems or severe visual impairment using corrective lenses; (4) severe uncorrected hearing deficit; (5) have decompensated cardiovascular diseases, such as angina, heart failure; (6) epilepsy; (7) motion sickness; (8) experiencing cybersickness during the familiarization game (9) health problem that makes it impossible to use immersive Virtual Reality; (10) serious clinical conditions with uncontrolled symptoms or instability and (11) missing the first 2 consecutive sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5xcszv2	The effect of a 3D Device compared to Elastic Bandages in controlling Swelling after Facial Surgery	Not yet recruiting	Intervention	2023-10-25	<NULL>	<NULL>	6537	Efficacy of a Personalized Rigid Device compared to Adhesive Tapes in controlling Edema in the postoperative period of Trauma Surgeries in Oral and Maxillofacial Surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade de Pernambuco - Departamento de Cirurgia e Traumatologia Buco-Maxilo-Facial	Núcleo de Tecnologias Estratégicas em Saúde (NUTES)	https://ensaiosclinicos.gov.br/rg/RBR-5xcszv2	<NULL>	Patients under the care of the Oral and Maxillofacial Surgery and Traumatology specialty at the Campina Grande Trauma Hospital, aged 18 years or older, regardless of gender, with unilateral and isolated zygomatic fractures classified as type III, IV, and V according to Knight and North&apos;s classification (1961), and treated by the same operator (surgeon) during the same surgical procedure	Presence of neurological deficit after the trauma episode; history of surgery in the facial region prior to the current trauma; systemic disease without clinical control; continuous drug therapy for special patients, with coagulopathies, rheumatic and autoimmune diseases; chronic use of nicotine, alcohol or drugs; trans or postoperative complications; sensitivity/allergy to elastic tape or any component that makes up the personalized rigid device; deny participation in the study and do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-44vqd7r	Safety and efficacy evaluation of a health product using the product at home	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6538	Evaluation of gynecological and dermatological acceptability of a health product under normal conditions of use with cosmetic appreciation (volunteer opinion assessment)_	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-11	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Maredifiori Indústria e Comércio de Cosméticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-44vqd7r	<NULL>	Women; age between 18 to 59 years old;  phototype: I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; pregnant or lactating women; participants with a history of allergy to the material used in the study; atopy history; use of vaginal cream; participants with a history of allergy to products in the tested category; recent gynecological surgeries; discharges; immunodeficiency carriers; kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the start of the study; any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5ghx4y6	Effects of acute administration of a single dose of Cannabis Extract on laboratory-induced pain: comparison with placebo	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6539	Investigation of the effects of acute administration of Full Spectrum Cannabis Extract on Experimentally Induced Pain: A randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-10-30	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo  FMRP - USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo  HCFMRP - USP	https://ensaiosclinicos.gov.br/rg/RBR-5ghx4y6	<NULL>	Participants aged at least 18 years; both genders; absence of current or previous history (self-reported) of substance abuse, psychiatric disorders and/or neurological disorders, cardiovascular diseases, pulmonary diseases, high blood pressure; absence of painful disorders and complaints of chronic or acute pain; score less than ten on the Patient Health Questionnaire (PHQ-9), on the Generalized Anxiety Instrument (GAD-7); absence of experience of pain of any kind in the seven days prior to the experimental session, assessed by means of a checklist questionnaire of pre-existing painful conditions and the perception of present pain (Visual Analog Pain Scale)	Adverse reactions of any nature after the use of cannabis extract; failure to complete the experimental tasks that make up the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-749zsx6	Effects of Non-Invasive Electrostimulation on students with Anxiety at an university in the Amazon: a randomized clinical trial	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6540	Effects of Non-Invasive Neuromodulation on academics with Anxiety Disorders at an university in the Amazon: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Instituto de Saúde e Biotecnologia	Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-749zsx6	<NULL>	be aged between 18 and 40, of both sexes, be a university student at ISB/UFAM, have a clinical diagnosis, according to the criteria of the American Psychiatric Association 5th edition - DSM-V (2014), of anxiety disorders, and cognitive ability to understand the purpose of the research and to answer the scales and questionnaires	conditions such as uncontrolled epilepsy, individuals with metallic intracranial implants near the electrodes, pregnant women, history of brain surgery, tumor and undergoing psychotherapy at the time of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-55p8vr4	The effect of Neuromodulation and Restriction Therapy on the upper limb of people after stroke	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6541	Effects of transcranial Direct Current Stimulation and modified Constraint Therapy on upper limb motor function in people after chronic Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-55p8vr4	<NULL>	Single episode of stroke, ischemic or hemorrhagic, with at least six months between the ictus and their inclusion in the study, proven by a medical report; aged between 40 and 70 years; classified with a degree of spasticity with a score less than or equal to 2, detected using the Modified Ashworth Scale for spasticity; active extension capacity of 10 degrees in the metacarpophalangeal and interphalangeal joints, and 10 degrees in the wrist joint; no cognitive deficit (score less than 24), verified using the Mini-Mental State Examination; pain threshold with a maximum score of 4 in the affected upper limb, verified using the Visual Analog Pain Scale	Those who had clinical evidence of multiple brain injuries and other comorbidities, inability to ambulate and instability to walk with the healthy upper limb (HUL) immobilized, failure to perform the training tasks with the paretic HUL, or symptoms of depression or severe anxiety, as verified by the Hospital Anxiety and Depression Scale, would be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-427g9ht	Comparison study of the different Surgical Techniques for the treatment of Benign prostatic growth with large volume: Endoscopic Laser Treatment x Minimally-invasive Abdominal Treatment x Endoscopic Treatment with Bipolar Energy	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6542	Randomized clinical trial evaluating the Surgical Treatment of large-volume Benign Prostatic Hyperplasia: Endoscopic Enucleation with Holmium Laser x Minimally-invasive Simple Prostatectomy x Bipolar Transurethral Resection of Prostate	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-30	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-427g9ht	<NULL>	Prostatic volume between 80 and 150mL measured by abdominal ultrasound of the prostate. Present at least one indication criteria for surgical treatment of Benign prostatic hyperplasia (BPH): renal failure with bilateral ureterohydronephrosis, recurrent macroscopic hematúria, acute urinary retention, recurrent urinary tract infection secondary to high post-void volume, moderate to severe voiding urinary symptoms even with clinical treatment interpreted by International Prostate Symptom Score (IPSS) &gt; 15 and/or maximum urinary flow (Qmax) &lt; 12mL/s,  moderate to severe voiding urinary symptoms interpreted by International Prostate Symptom Score (IPSS) &gt; 15 and/or maximum urinary flow (Qmax) &lt; 12mL/s in patients intolerant to pharmacological therapy	Prostate câncer. Neurogenic bladder. Previous prostatic surgeries. Bladder stones. Urethral pathologies. Impossibility of suspending anticoagulants or anti-platelet agentes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2hs894w	Effects of Oxandrolone on clinical outcomes and muscle mass in patients with Septic shock	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6543	Effects of Oxandrolone on clinical outcomes and muscle mass in patients with Septic shock: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Estadual Paulista Júlio de Mesquita	Universidade Estadual Paulista Júlio de Mesquita	https://ensaiosclinicos.gov.br/rg/RBR-2hs894w	<NULL>	Individuals over 18 years of age; of both genders; hospitalized with a diagnosis of septic shock in the Intensive Care Service of the Hospital das Clínicas da Faculdade de Medicina de Botucatu from October 2023 to June 2025	Patients with the following characteristics will be excluded: pregnant women; noradrenaline dose &gt; 2.0µg/Kg/min; patients with non-functioning gastrointestinal tract; diagnosis of brain death; patients with a history of previous use of anabolic steroids; association with other types of shock (cardiogenic, hemorrhagic or hypovolemic); patients with breast or prostate cancer and those who spontaneously refuse to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-9kkjvnj	Pharmaceutical guidance for optimizing the use of asthma medications	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6544	Pharmaceutical intervention to optimize the use of inhalation devices in asthma patients: a randomized, open clinical tirial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-02	Universidade Federal do Rio Grande do Norte	Secretaria de Estado da Saúde Pública do Rio Grande do Norte - SESAP	https://ensaiosclinicos.gov.br/rg/RBR-9kkjvnj	<NULL>	Both sexes. Aged 18 years or older. Confirmed diagnosis of Asthma through spirometry. Patients currently using or starting the use of a dry powder inhaler (Aerolizer, Turbuhaler) and/or inhalation solution (Respimat system) on D0. Informed and voluntary consent to participate in the clinical trial	Conditions that may influence the learning of the inhalation technique (psychiatric, neurological, or rheumatological disorders). Presence of respiratory diseases other than asthma. Ongoing viral or bacterial respiratory infection. Dependency on third parties for DI handling. Hearing impairment. Severe visual impairment. Treatment with a different DI other than Aerolizer, Turbuhaler, and Respimat. Active smoking. Undergoing respiratory physiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5y8ntfq	The effect of Strength Training (resistance) on inflammatory markers, physical performance and fatigue symptoms in women with fatigue resulting from Breast Cancer treatment	Not yet recruiting	Intervention	2023-10-30	<NULL>	<NULL>	6548	Understanding the role of Strength Training on fatigue (sensation and fatigability) in women with a history of Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-07	Universidade Federal do Triângulo Mineiro	Grupo de pesquisa em exercício, nutrição e fisiologia aplicada	https://ensaiosclinicos.gov.br/rg/RBR-5y8ntfq	<NULL>	Women; over 25 years old; undergoing treatment for breast cancer or a breast cancer survivor; fatigue.	Practitioners of resistance exercises or similar exercises; vegetarian; smokers; alcoholics; with endocrine diseases; gynecological; joints; cardiac; myopathies; arthropathies; neuropathies; muscle disorders; thromboembolic; infectious diseases; metastases; concomitant tumors.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-359p69v	AtivaRS project: Exercise Practice to reduce Sedentary Behavior in the population	Not yet recruiting	Intervention	2023-08-21	<NULL>	<NULL>	6552	AtivaRS project: Combating Sedentary Lifestyle	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade do Vale dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-359p69v	<NULL>	Sedentary individuals; aged between 20 and 60 years; with no medical contraindications for physical exercise; must own a smartphone; agree to participate in the research by signing the informed consent form	Individuals who experience angina during exertion; history of acute myocardial infarction within the 12 months prior to the start of the protocol; require oxygen supplementation; exhibit clinical instability in the month preceding the protocol initiation; uncontrolled hypertension; visual diseases that prevent the performance of the protocol; chronic conditions  hindering participation in the exercise protocol; illiterate; refuse to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-10w3x7r3	Bioimpedance, respiratory health and inflammation in adults with Cystic Fibrosis: a prospective observational study	Not yet recruiting	Observational	2023-10-31	<NULL>	<NULL>	6556	Phase angle of bioelectrical impedance, lung function, and systemic inflammation in adults with Cystic Fibrosis: a prospective observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-20	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-10w3x7r3	<NULL>	Adults of both genders; aged 18 to 59; with Cystic Fibrosis; under the care of a specialized outpatient clinic at a tertiary hospital	Comorbidities characterized by systemic low-grade chronic inflammation or malabsorptive syndromes, except for those secondary to Cystic Fibrosis; malignant neoplasm; edema; chronic kidney disease with glomerular filtration rate less than 60 mg/dL; end-stage organ failure; amputated limbs; gastric or intestinal resections; implanted cardiac devices; chronic use of oral immunosuppressants or anti-inflammatory drugs; initiation of diuretic use or dose modification 3 months prior to recruitment; pulmonary exacerbations within 3 months of recruitment; ethical restrictions that prevent proper consent for study participation; women who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-10sghzys	Use of low-power laser to control pain and discomfort due to the use of mini-implants: a clinical research	Not yet recruiting	Intervention	2023-11-03	<NULL>	<NULL>	6560	Use of low-level laser therapy to control pain and discomfort resulting from skeletal anchorage with miniscrews: a triple-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	karine cestaro mesquita	Centro Universitário Christus	https://ensaiosclinicos.gov.br/rg/RBR-10sghzys	<NULL>	healthy volunteers; both genders; between 18 and 55 years old; showing the need for lateral distalization of the teeth based on the use of an orthodontic mini-implant	Patients with systemic and/or oral diseases; Use of anti-inflammatory medication or antibiotics in the last 24 months and chronic consumption of alcohol or tobacco, or history of installation and/or previous rejection of mini-implants; who did not have uncontrolled periodontal disease; patients with no history of radiotherapy, or using medication with bisphosphonates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-7phn8yv	Efficacy of analgesics in controlling pain associated with the insertion of a Copper or Hormone Intrauterine Device	Not yet recruiting	Intervention	2023-11-06	<NULL>	<NULL>	6564	Double-blind clinical trial, phase IV, prospective, national, single-center, randomized, to evaluate the efficacy of prophylactic administration of DEC103 compared to placebo in controlling pain associated with the insertion of a Copper Intrauterine Device (TCu380A IUD) or Intrauterine System with Levonorgestrel (LNG-IUS) 52 mg - DEC103-IV0123	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-11-13	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-7phn8yv	<NULL>	Women; with ability to confirm voluntary participation and agree to all the purposes of the trial by signing and dating the Informed Consent Form; age between 18 and 49; participants who will undergo the TCu380A Intrauterine Device (IUD) or LNG 52mg Intrauterine Device (IUD) insertion procedure for the first time; nulliparous women	Any clinical observation finding (clinical/physical evaluation) or laboratory condition that is interpreted by the investigating physician as a risk to the research participant&apos;s participation in the clinical trial or presence of uncontrolled chronic disease; chronic pelvic pain of any etiology; abnormality in the uterine cavity; psychiatric disorders; chronic use of medications that interfere with the pain threshold, e.g.: antidepressants and anticonvulsants; use of analgesics and/or anti-inflammatory drugs in the last 24 hours before the procedure; signs and/or symptoms of vaginal and/or cervical infection; contraindication to the use of Trometamol Ketorolac 10 mg, or Dipyrone Monohydrate + Scopolamine Butylbromide + Hyoscyamine Hydrobromide + Homatropine Methylbromide, 300 mg + 6.5 mcg + 104 mcg + 1mg; current alcohol or illicit drug use disorder; breastfeeding; participants with known allergy or hypersensitivity to the components of the drugs; participants with a current medical history of cancer and/or treatment for cancer in the last 5 years; participated in clinical trial protocols in the last 12 (twelve) months (CNS Resolution 251, of August 7, 1997, item III, sub-item J), unless the investigator judges that there may be a direct benefit to the investigator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-95vw7sj	Effect of Aerobic Exercise on Anxiety level in healthy individuals	Not yet recruiting	Intervention	2023-11-08	<NULL>	<NULL>	6566	Comparison of the acute effect of Aerobic Exercise performed at different intensities on State Anxiety level in healthy individuals exposed to anxiogenic stimuli	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-06	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-95vw7sj	<NULL>	Both gender; aged between 18 and 40 years old; be literate	Be in the menstrual period (applicable for women); use psychotropic drugs;have restrictions to perform physical exercise (determined by the Physical Activity Readiness Questionnaire); have a diagnosis of anxiety disorder and/or depression; being in the gestational period (applicable to women)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7d3yxz3	Effects of the Vibrating Platform on Nerve Injury caused by chemotherapy	Not yet recruiting	Intervention	2023-11-10	<NULL>	<NULL>	6567	Effects of Whole Body Vibration in chemotherapy periphery induced Neuropathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Hospital do Cancer II	Hospital do Cancer II	https://ensaiosclinicos.gov.br/rg/RBR-7d3yxz3	<NULL>	protocol of carboplatin associated with paclitaxel at a high dose; curative intent;  ovarian cancer; endometrial cancers	previous chemotherapy treatment; pre-existing neuropathy; metastases unstable bone fractures; cardiac pacemaker; lower limb surgeries in the last year; presence of metallic prostheses; deep venous thrombosis for less than 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-32592zd	Randomized comparative study of double J catheter with reduced tip vs conventional double J catheter (normal tip)	Not yet recruiting	Intervention	2023-11-13	<NULL>	<NULL>	6570	Randomized comparative study of customized double J loop catheter X convencional double J catheter	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Irmandade da Santa Casa de Misericórdia de Santos	Irmandade da Santa Casa de Misericórdia de Santos	https://ensaiosclinicos.gov.br/rg/RBR-32592zd	<NULL>	Patients of both genders; at least 18 years old; indicated for a double J catheter, regardless of the study; who understand and accept informed consent	Patients who do not agree to participate; those under 18 years of age; those with a urinary catheter at the time of the intervention or less than 6 months ago; those with neurological diseases or those using antidepressants; bilateral catheters; those with malignant disease; active infection; ureter injury greater than 2 on the Traxer scale; antegrade double J; patients with chronic pain and pelvic radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-4h8z5js	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Intervention	2023-11-16	<NULL>	<NULL>	6576	Evaluation of the gynecological and dermatological acceptability of an intimate fluid for health under normal conditions of use_INT01.2023	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-14	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Intt Comercio, Distribuição, Importação e Exportação de Cosmeticos LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4h8z5js	<NULL>	Women; age 18 to 59 years; phototype I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; pregnant or lactating women; participants with a history of allergy to the material used in the study; atopy history; use of vaginal cream; participants with a history of allergy to products in the tested category; recent gynecological surgeries; discharges; immunodeficiency carriers; kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the start of the study; any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7hqhj3y	"Use of calcium carbonate supplementation to prevent Pre-eclampsia in pregnant women high risk:
randomized clinical trial"	Not yet recruiting	Intervention	2023-11-16	<NULL>	<NULL>	6581	Use of calcium carbonate supplementation to prevent Pre-eclampsia in pregnant women high risk: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Centro de Ciências Biológicas e da Saúde - Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7hqhj3y	<NULL>	Pregnant women who are up to the 20th week of pregnancy at the first stage of the approach; minumium age of 15 years; who present one or more of the risk factors: history of pre-eclampsia, multiple pregnancy, chronic hypertension, type 1 or 2 diabetes, autoimmune disorder) will be included in the study. , kidney disease, nulliparity, body mass index &gt;30 kg/m2, family history of preeclampsia (first-degree relative), sociodemographic characteristics (African American, low socioeconomic status), age &gt;35 years, history factors (pre-low birth weight or small birth for gestational age, previous adverse pregnancy outcome, interval &gt;10 years since previous pregnancy, term birth without previous complications) for the occurrence of pre-eclampsia; and/or low intake of calcium	Pregnant women with known placental abnormalities; current pregnancy as a result of in vitro fertilization; regular use of platelet-active drugs; known fetal abnormalities; uterine bleeding documented within one week of screening; uterine malformations; pregnant women with chronic systemic hypertension; sickle cell anemia; those under 15 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-2fvknfd	Stability of printed versus conventional retainers: randomized clinical trial	Not yet recruiting	Intervention	2023-11-20	<NULL>	<NULL>	6591	Stability of 3x3 digital printed versus conventional retainers: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-20	Faculdade de odontologia de Bauru - Universidade de São Paulo	Faculdade de odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2fvknfd	<NULL>	Volunteers in the final phase of orthodontic treatment; of both sexes; in the permanent denture phase; with erupted second molars; all dental elements present without changes in shape or number; adequate correction of malocclusion and alignment of dental elements; good collaboration and oral hygiene	Volunteer who had complex initial malocclusions that required large transverse expansions and/or orthognathic surgery; poor oral hygiene; history of periodontal disease or systemic conditions that may influence periodontal health; any type of condition that makes it impossible to carry out clinical care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-296drgz	Effects of deep relaxation on pain in patients with chronic wounds	Not yet recruiting	Intervention	2023-11-20	<NULL>	<NULL>	6592	Effects of Hypnosis on pain: a clinical trial in patients with chronic wounds	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Universidade do Estado da Bahia	Secretaria Municipal de Saúde de Salvador	https://ensaiosclinicos.gov.br/rg/RBR-296drgz	<NULL>	Being 18 years of age or older; both genders; have a wound that has existed for four weeks or more, and complain of moderate to severe pain	Patients with altered hearing acuity;  patients with disorientation in time and space	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-6ktm4zx	Application of laser to surgical wounds for breast cancer surgery	Not yet recruiting	Intervention	2023-11-22	<NULL>	<NULL>	6603	Photobiomodulation in operative wounds in breast surgery by Malignant Neoplasm	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-08	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-6ktm4zx	<NULL>	Patients over 18 years of age; diagnosed with any malignant neoplasm of the breast and who will undergo breast surgery	Patients diagnosed with benign breast neoplasia; diagnosed with bilateral malignant neoplasm; diagnostic sectorectomy; musculocutaneous flap; inflammatory T4B staging due to dermal infiltration; with tattoo or hematoma in approximately 30% of the extent of the surgical wound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-5tnzyc9	Home programs as intervention for babies with Down Syndrome: a feasibility study	Not yet recruiting	Intervention	2023-11-24	<NULL>	<NULL>	6609	Home programs for early intervention in Down Syndrome: a feasibility study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5tnzyc9	<NULL>	Children with Down Syndrome. Children util 3 years old.	Children with associated comorbidities as cerebral palsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-937bj9r	Educational hypermedia for risk classification	Not yet recruiting	Intervention	2023-11-27	<NULL>	<NULL>	6610	Elaboration, validation and effects of educational software in embracement and obstetric risk classification	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Centro Universitário Inta	Centro Universitário Inta	https://ensaiosclinicos.gov.br/rg/RBR-937bj9r	<NULL>	Being a student regularly enrolled in the disciplines of Process of Care in Sexual and Reproductive Health (seventh semester) and Hospital Internship (ninth semester); Being regularly enrolled from the sixth semester; Being over 18 years old; Being attending the university during the period of data collection	Have previous practical experience in embracement and risk classification in obstetrics (students who carry out or have carried out extracurricular internships in this area)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-37gx2f4	The effect of Interprofessional Clinical Simulation on the care of patients with Myocardial Infarction	Not yet recruiting	Intervention	2023-11-27	<NULL>	<NULL>	6613	Interprofessional Clinical Simulation as a teaching-learning strategy in the care of patients with Acute Coronary Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de Santa Maria	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-37gx2f4	<NULL>	Being a nursing and medicine undergraduate student at the Pontifical Catholic University of Rio Grande do Sul (PUCRS); a technical nursing course at the Fundação Universitária de Cardiologia Professional School (FUC), who has completed the disciplines that address patient care with Acute Coronary Syndrome (ACS); regularly enrolled in these institutions; both genders	Students with total lockout at the time of data collection; on leave for health treatment; with certification from any technical or higher course in the health area, considering that they may have previous knowledge on the subject, thus favoring their performance in the simulated scenario	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-26rcv2n	Application of Physiotherapeutic Devices in patients with Lombalgy	Not yet recruiting	Intervention	2023-11-29	<NULL>	<NULL>	6618	Application of Electrothermalphototerapeutic Current in patients with Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-26rcv2n	<NULL>	Localized lumbar pain; female and male; age 18 to 85 years; numerica pain scale (NPS more than 3; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology	pregnant women; lactating women; sedentary individuals; Body Mass Index (BMI) greater than or equal to 30 kg/m2; without physical therapy treatment simultaneously with the study period; surgery in the lumbar region; without clinical diagnosis of low back pain; not present low back pain radiating to the glutes and lower limbs; sensory alteration in the lower limbs and the use of medication to relieve low back pain 48 hours before the performance of the exercises;  neurological disease, previous diagnosis of heart disease; acute lung disease; uncontrolled hypertension beginning of medication use less than 1 year ago); orthopedic injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-5r7zrs2	The effect of photobiomodulation therapy on Menopause	Not yet recruiting	Intervention	2023-11-30	<NULL>	<NULL>	6624	Effect of Photobiomodulation Therapy on Genitourinary Syndrome of Menopause: blinded, controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5r7zrs2	<NULL>	Women who had natural menopause at least 1 year ago; aged between 45-65 years; without use of hormone replacement therapy for at least 3 months; being sexually active; presenting a diagnosis of sexual dysfunction and urinary incontinence; not performing exercises for the pelvic floor muscles; have a negative Pap smear result for cervical cancer precursor cells in the last year	Women who present null value in the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF); score above 26.55 in the Female Sexual Function Index (FSFI); those unable to understand simple verbal commands or who do not comply with the guidelines provided during the evaluation; volunteers with infectious and degenerative diseases; those who present genital prolapse III or IV according to the Baden-Walker Scale; report of unbearable pain during the gynecological evaluation; have more than 20% absences in the period of intervention; those who decide not to continue in the research and/or withdraw their consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-75yp56r	The Effect of Clinical Simulation on Teaching and Learning in occupational therapy	Not yet recruiting	Intervention	2023-12-05	<NULL>	<NULL>	6630	The Effect of Clinical Simulation on Teaching and Learning in occupational therapy: a quasi-experiment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-75yp56r	<NULL>	Undergraduates aged eighteen or over; regularly enrolled in the seventh and eighth periods; in the occupational therapy course at Federal University of Triangulo Mineiro; who are taking the following courses  Supervised Internships one, two, three, and four; the study will be carried out with fifty-three occupational therapy graduates from the Federal University of Triângulo Mineiro; the sample size calculation will be carried out after the pilot study	Students with signs and symptoms of flu syndrome; pregnant women; students with medical conditions and symptoms of flu syndrome; students with medical conditions that make it impossible to transfer the that make it impossible to safely transfer the patient from the bed to the wheelchair; inactive students; students on sick leave; students who did not take part in any of the any of the research stages	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-8pjxs75	Technology in Postural Education in Online and Online Format for elementary school students	Not yet recruiting	Intervention	2023-12-05	<NULL>	<NULL>	6631	Technology in Postural Education in Online and Online Format for Elementary School Students: A Non-Randomized Clinical Trial	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-01-25	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8pjxs75	<NULL>	Children of both sexes, aged between 6 and 12 years old, who understand the tests to be carried out and agree to participate in the postural intervention; adolescents of both sexes, aged between 10 and 17 years old, who understand the tests to be carried out and agree to participate in the postural intervention; enrolled and attending public and private schools in municipalities in the South of Brazil;teachers of both sexes and different subjects from participating schools; parents and/or legal guardians of participating students	students with diagnosed motor and cognitive disabilities, previously acquired physical disabilities, congenital and neurological changes; students who do not attend 2/3 of the Technology in Postural Education Online and In-person Program interventions; teachers who do not attend training programs;Illiterate parents and/or guardians	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-26d4nwz	Evaluation of the epidemiological profile tailored to dysfunctions of the urinary tract, intestinal and sexuality of people with Spinal Cord Injury in Brazil	Not yet recruiting	Observational	2023-12-06	<NULL>	<NULL>	6632	Epidemiological profile of patients with Spinal Cord Injury: dysfunctions of the urinary, intestinal and sexual systems	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26d4nwz	<NULL>	Patients with a spinal cord injury; regardless of gender and ethnicity; aged 18 years or over; who wished to participate in the research	Individuals who do not meet the inclusion criteria described above; people with cognitive or communication limitations that make it impossible to properly conduct the interview	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-87kzkbm	Association between glucose control and exercise capacity in Type 1 Diabetic adolescents	Not yet recruiting	Observational	2023-12-07	<NULL>	<NULL>	6636	Association between glycemic control and cardiorespiratory fitness in Type 1 Diabetic adolescents	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-08	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-87kzkbm	<NULL>	For the Type 1 Diabetes Mellitus (DM1) group: Individuals, female, with a clinical and laboratory diagnosis of DM1; aged between 13 and 17 years; classified as pubertal (from P3M3), according to biological maturation; agreeing to the procedures and signing the Free and Informed Assent Form and the Free and Informed Consent Form. For the control group: individuals without a clinical or laboratory diagnosis of DM1; agreeing to the procedures and signing the Informed Consent Form and the Informed Consent Form; matched by age, biological maturation and level of physical activity with the participants in the DM1 group	For the Type 1 Diabetes Mellitus (DM1) group: presence of complications such as diabetic retinopathy, nephropathy and/or neuropathy; respiratory exchange coefficient lower than 1.1 in the Cardiopulmonary Exercise Test; loss of data related to the variables of the Cardiopulmonary Exercise Test; absence of information or incorrect completion of information on the time of diagnosis of diabetes, laboratory tests, body composition and level of physical activity. For the control group: respiratory exchange coefficient lower than 1.1 in the Exercise Cardiopulmonary Test; loss of data related to the Exercise Cardiopulmonary Test variables	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-5b6q7vf	Task-Specific Training Approach involving Augmented Reality Games (Interact Protocol) in children with Spastic Cerebral Palsy: a randomized controlled trial	Not yet recruiting	Intervention	2023-12-11	<NULL>	<NULL>	6643	Task-Specific Training in an Augmented Reality Context (Interact Protocol) in children with Spastic Cerebral Palsy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5b6q7vf	<NULL>	Children with a medical diagnosis of unilateral and bilateral spastic cerebral palsy; level of GMFCS (Gross Motor Function Classification System) I and II; who walk without walking aids; MACS (Manual Ability Classification System) I, II, and III; with modified Ashworth score from 0 to 1+; aged between 6 and 12 years; who understand simple verbal commands; with mass and height within the normal growth curve	Children who have dystonic, athetoid, or ataxic tonus classification; GMFCS level III, IV and V; MACS IV and V; with modified Ashworth score from 2 to 4 in limbs; with cognitive impairment that may compromise understanding of verbal commands; who receive orthopedic surgical procedures less than a year ago; with application of chemical blockages less than 6 months ago; with physical deformities that prevent or compromise the execution of the proposed activities; with use of medications that may alter strength or muscular tone; visual or auditory sensory deficits without correction with auxiliary devices; cardiorespiratory limitations of any intensity; who have undergone other intensive therapies less than 6 months ago; children that do not like video games	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-8k52dw8	The effects of photobiomodulation on the gut-brain axis in adolescents with depression.	Not yet recruiting	Intervention	2023-12-11	<NULL>	<NULL>	6647	The effects of photobiomodulation on the gut-brain axis in adolescents with depression: a double-blind randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8k52dw8	<NULL>	All individuals of both sexes aged 15 to 17 years with a diagnosis of depression made by a physician will be included in this study. Participants must be duly enrolled and attending schools of the 8th Regional Education Management (GERED) in Campos Novos/SC.	Participants with cognitive problems and unable to answer the questionnaires will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-2337ckv	Progressive exercises for people with a sprained ankle	Not yet recruiting	Intervention	2023-12-12	<NULL>	<NULL>	6653	Rehabilitation of individuals with ankle sprains in their different stages	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-2337ckv	<NULL>	Participants must be in a subacute phase of the ankle sprain (between one and eight weeks after the sprain event); of both sexes; and aged between 15 and 45 years	People with fractures in the ankle or foot region diagnosed after the sprain; treatments with a plaster splint that cannot be removed; the report of any neurological, musculoskeletal, cardiovascular, pulmonary or metabolic condition that may interfere with or contraindicate research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-104736f4	Study on the implementation of Long-Action Injectable Pre-exposure Prophylaxis in male adolescents who have sex with men and transgender individuals, aged 15 to 19, in Brazil. PrEP 15-19 Study	Not yet recruiting	Intervention	2023-12-14	<NULL>	<NULL>	6656	PrEP1519 (fase 2)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo	Instituto de Saúde Coletiva, Universidade Federal da bahia	https://ensaiosclinicos.gov.br/rg/RBR-104736f4	<NULL>	Self-identified men who have sex with men, non-binary assigned as male at birth, and transgender people; age between 15 and 19 years; HIV negative status (including HIV-rapid test for oral PrEP and HIV-viral load for CAB-LA PrEP) at screening/enrollment; at high risk for sexually acquiring HIV infection (condomless receptive or insertive anal intercourse in the 6 months prior to screening/enrollment, condomless vaginal intercourse in the last 6 months, any STI episode in the last 6 months, post-exposure prophylaxis (PEP) use at least once in the last 6 months, frequent use of alcohol or drugs before or during sexual intercourse, transactional or commercial sex); PrEP request by the participant who shows vulnerability and/or increased risk of HIV infection, based on risk management counseling and vulnerability context assessment by the research team	Weight under 35 Kg; currently participating in another interventional trial of PrEP agents, experimental medication or HIV vaccine trial; participant shows, according to a specialized psychological assessment, mental and/or intellectual impairment that do not allow PrEP use; only applicable for CAB-LA PrEP: surgically-placed buttock implants, including injected silicon, or fillers, per self-report; diagnosis of chronic hepatitis B2 with indication for antiviral treatment, alanine aminotransferase, ALT &gt; 2 times the upper limit of normal, ULN; total bilirubin &gt; 2.5 times ULN; Current or chronic history of liver disease, e.g., non-alcoholic or alcoholic steatohepatitis, or known hepatic or biliary abnormalities, with the exception of Gilbert&apos;s syndrome, asymptomatic gallstones, or cholecystectomy; any known coagulopathy that contraindicates receiving intramuscular injections; use of carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifampin and/or rifapentine; plan to relocate out of the area during the study period; a history or presence of allergy to the cabotegravir or its components; Only applicable for oral PrEP: estimated glomerular filtration rate, eGFR &lt; 60 mL/min/1.73m2; history of spontaneous bone fracture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-3pxmycv	Association of an Aerobic Exercise protocol with Systemic Photobiomodulation ) for treatment of women with Fibromyalgia	Not yet recruiting	Intervention	2023-12-19	<NULL>	<NULL>	6665	Effects of the association of an Aerobic Exercise protocol with Systemic Photobiomodulation (transcutaneous ILIB) on the level of pain, fatigue and quality of life in women with Fibromyalgia: a single blind randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-3pxmycv	<NULL>	Women; aged between 18 years and 60 years; who have been diagnosed with fibromyalgia (the diagnosis will be made by a patient&apos;s own referring physician and confirmed by a PhD physiotherapist with eight years of experience in the field of rheumatology, taking into consideration the diagnostic criteria for fibromyalgia set forth by the American College of Rheumatology); with cognitive capacity to understand the study according to the Mini Mental State Examination cutoff score; classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version; and interest in participating in the entire experimental protocol	Participants with uncontrolled systemic diseases such as diabetes mellitus and systemic arterial hypertension; neurological and musculoskeletal conditions that could directly interfere with assessments, such as paralysis, significant sensory alterations, advanced joint diseases (such as joint replacements or osteoarthritis); absolute contraindication to phototherapy, such as the presence of neoplasia; individuals with malnutrition (Body Mass Index -BMI) less than 18.5 kg/m2) or morbid obesity (Body Mass Index -BMI greater than or equal to 40 kg/m2)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-2bzty9v	Low Power Laser in Pain and Nipple injury due to Breastfeeding	Not yet recruiting	Intervention	2023-12-19	<NULL>	<NULL>	6668	Early Photobiomodulation in Pain and Nipple injury resulting from Breastfeeding	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	Universidade Estadual de Londrina - UEL	Centro de Ciências da Saúde - Departamento de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-2bzty9v	<NULL>	Mothers who are allocated in the rooming-in of the participating maternity hospitals; single pregnancy; gestational age equal to or greater than 37 weeks; nursing their babies; who has a smartphone to enable follow-up in the survey	Contraindication to breastfeeding; unpretentiousness to breastfeed; child with clinical conditions that may interfere with or prevent breastfeeding during the research period; anomalies in the breasts and/or nipples that may interfere with the breastfeeding process; contraindications for local photobiomodulation or transcutaneous ILIB: diagnosis of autoimmune disease (lupus or rheumatoid arthritis); tumor diagnosis; using antiplatelet medications; previous history of malignant pathology; pacemaker carrier, glaucoma; prior photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-4wgg9bk	Can smartphones be an alternative to reducing sitting time?	Not yet recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6671	Can Smartphone be an alternative to combat sedentary behavior?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4wgg9bk	<NULL>	Being 18 years of age or older; both genders; being duly registered; being regularly attending classes	Do not accept to participate in the research at any time; do not participate in one of the data collection moments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-9k5tc4d	Assessment of pH stability and influence on tooth sensitivity after in-office dental whitening in adult patients: a double-blind randomized clinical trial	Not yet recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6675	Influence and stability of pH on the sensitivity of in-office teeth whitening in adults: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-05	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9k5tc4d	<NULL>	Participants over 18 years old; both genders; with good general and oral health conditions; caries-free upper teeth and upper anterior teeth free of restorations on the buccal surface; they should also have  A2 or darker colored central incisors, evaluated against a tooth value-driven visual color scale  (Vita Classical, Vita BleachedGuide)	Pregnant women; nursing mothers; smokers; users of fixed orthodontic appliances; with pre-existing anterior restorations; presence of severe intrinsic stains (stains due to tetracycline use, fluorosis and pulpless teeth); participants with a previous history of tooth sensitivity or any associated pathology (bruxism , gingival recession, non-carious lesion with exposed dentin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-1049dx8g	Eficacy and safety of Continuous and Micropulse Cyclophotocoagulation on the treatment of refractory Glaucoma	Not yet recruiting	Intervention	2023-12-22	<NULL>	<NULL>	6677	Eficacy and safety of Continuous and Micropulse Transscleral Cyclophotocoagulation on the treatment of refractory Glaucoma. A randomised clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-1049dx8g	<NULL>	Visual acuity better than or equal to light perception; diagnosis of refractory glaucoma, by the attending physician: uncontrolled intraocular pressure, presence of previous fistulizing glaucoma surgery and/or glaucoma drainage implant, contraindication to fistulizing surgery and glaucoma drainage implant; indication of cyclophotocoagulation by the attending physician	Under 18 years old; previous cyclophotocoagulation procedure; presence of retinal and/or choroidal detachment; presence of perilimbic scleral thinning or any other anatomical change that prevents transscleral cyclophotocoagulation; presence of an eye tumor; patients unable to perform the proposed exams or remain in the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4bwtfbc	Immediate effect of ischemia on muscle performance in CrossFit athletes	Not yet recruiting	Intervention	2023-12-22	<NULL>	<NULL>	6679	Acute effects of different Ischemic Preconditioning protocols on performance, strength and muscle activation of CrossFit practitioners: crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4bwtfbc	<NULL>	Healthy subjects; CrossFit practitioners; both genders; age between 18 and 35 years old; at least 1 year of practice; no history of metabolic, cardiovascular or locomotor system diseases that would contraindicate the practice of exercise and the use of vascular occlusion; Ankle Brachial Index between 0.91 and 1.30; respond negatively to all items on the Physical Activity Readiness Questionnaire	Present during the experiment any aggravating cardiovascular, pulmonary or musculoskeletal problems; not completing all the sessions proposed by the study; give up the same	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-7gfvn3y	Assessment of the self-care capacity of informal caregivers of elderly people living with Dementia	Not yet recruiting	Intervention	2023-12-22	<NULL>	<NULL>	6680	Self-care capacity of informal caregivers of elderly people with Dementia: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-7gfvn3y	<NULL>	Being 18 years of age or older. Both genders. Being the main informal caregiver for elderly people with dementia. Being an informal caregiver for an elderly person with dementia for at least one year. Have access to a smartphone and internet and know how to use a messaging app	Have difficulty communicating, listening and understanding the questions asked by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-3xtxhtz	Effect of Low Pressure Fitness (LPF) on abdominal diastasis in postpartum women	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6682	Effect of the Low Pressure Fitness (LPF) technique on rectus abdominis diastasis in postpartum women: blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Faculdade de Ciências da Saúde do Trairi	Faculdade de Ciências da Saúde do Trairi	https://ensaiosclinicos.gov.br/rg/RBR-3xtxhtz	<NULL>	Primiparous or multiparous women aged 18 or over; from 12 weeks after birth, BMI less than or equal to 29 kg/m27; who gave birth vaginally to a single fetus after a full-term pregnancy; parity &lt;4; with a separation of the rectus abdominis muscles &gt;2 cm and ≥2 fingers wide, above, below or at the level of the navel; with the ability to adequately contract the Pelvic Floor Muscles and perform the hypopressive maneuver of the LPF® Method adequately; who do not have: history of previous cesarean section; perineal laceration; medical restriction that prevents participation in the proposed assessments and interventions (cardiorespiratory, respiratory (including excessive coughing or sneezing), neurological and/or musculoskeletal changes); any form of vulvovaginal pain, low back pain, pelvic pain, prolapse or incontinence; a pathology of the lower limb (e.g. fracture, surgery, neoplasm); history of pelvic or abdominal surgery; or with a history of smoking; history of multiple pregnancies; complications related to the last pregnancy, such as Polyhydramnios, fetal macrosomia, diabetes or hypertension	Postpartum women who are unable to understand and/or complete the study questionnaires; who have decompensated reflux and those who miss 3 consecutive sessions of the intervention protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-8rv93wn	Evaluation of the use of Cannabidiol in Third Molar Extraction	Not yet recruiting	Intervention	2023-10-17	<NULL>	<NULL>	6684	Evaluation of the use of Cannabidiol in Third Molar Extraction Surgeries	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8rv93wn	<NULL>	Patients of both genders. aged between 18 and 60 years. who are systemically healthy and who require surgery to remove the four third molars	Patients using drugs acting on the central nervous system. decompensated diabetics (glycated hemoglobin above 8%). consumption of any medication 15 days prior to inclusion in this study, patients with hypersensitivity to the drugs to be used in postoperative care, pregnant women or during lactation. chronic smokers and alcoholics. presence of periapical lesions. presence of pericoronitis lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-25ng5pt	Comparison of the use of a Biodressing and Laser Therapy for the treatment of Diabetic Foot Wounds	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6686	Comparison between the use of a Biocuration and Low Intensity Laser Therapy in the treatment of Diabetic Foot Ulcers	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-03-31	Universidade Federal do Delta do Parnaíba	Universidade Federal do Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-25ng5pt	<NULL>	Volunteers of both sexes;aged over 18; with a clinical diagnosis of type 2 diabetes mellitus; diabetic ulcers located in the foot region;who agree to take part in the study by signing the Informed Consent Form (ICF)	Ulcers located in other regions of the body; who are unable to attend the treatment days proposed by the research; who are using other types of coverage for diabetic ulcers, which hinder the use of Laser and the identification of the results proposed by this research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-7yqtbvk	Gel for orthodontic aligners	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6689	Chitosan gel and Melaleuca essential oil for orthodontic aligners - a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7yqtbvk	<NULL>	Participants will be included in the study: both sexes; aged between 18 and 30 years; absence of systemic disease known by the individual to affect periodontal tissues (such as cardiovascular diseases, diseases leading to neutropenia, diabetes, leukemia and AIDS); absence of periodontal disease prior to orthodontic therapy; absence of extensive restorations.	Participants who do not correctly follow the protocol for using gel in orthodontic aligners will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4r5xs6d	The effectiveness of Psychotherapy for patients who have attempted suicide	Not yet recruiting	Intervention	2023-12-28	<NULL>	<NULL>	6691	Construction of Psychotherapeutic Resources for the treatment and prevention of Suicidal Behavior	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-10	Pro Reitoria de Pesquisa - Universidade Federal de Minas Gerais	Fundação Hospitalar do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4r5xs6d	<NULL>	Being 18 yeas old or over; both genders; residing in the city of Belo Horizonte; have been admitted to João XXIII hospital after a suicide attempt and have a reference person  who attends the first session	Participants cannot be considered legally incompetent; present a medical or psychiatric condition that prevents informed consent or participation in outpatient treatment, such as active psychosis or manic phase and present homicidal ideas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-7p32sbb	Effects of different tonic, isometric, and isometric and vibratory Strength Training programs on Motor Symptomatology in People with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6700	Effects of different tonic, isometric, and isometric and vibratory Strength Training programs on Motor Symptomatology in People with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-15	Universidad de las Americas	Universidad de Atacama	https://ensaiosclinicos.gov.br/rg/RBR-7p32sbb	<NULL>	Individuals of both sexes; diagnosis of Parkinson&apos;s disease in stages I-III according to the Hoehn and Yahr classification; authorized by your treating physician to participate in the intervention program; controlled medication; able to follow verbal instructions and with motor autonomy; mini - mental exam score greater than 23 points; Signed informed consent to participate in the study	Participants with adherence below 80% to the different types of intervention sessions will not be included in the results analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-2mpn8qk	Coaching leadership development program for nurses	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6702	Effectiveness of a program for developing leadership coaching in nurses: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Hospital de Clínicas da UNICAMP	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2mpn8qk	<NULL>	Nurses; minimum age 18 years; both genders; provide direct assistance to the patient; work for at least three months at the institution; not have a temporary contract; not have undergone coaching training or have previously participated in a coaching process	Nurses who do not attend two sessions of the intervention program; professionals who do not respond to the instruments in T7; those who leave more than 50% of the questionnaire responses blank, at any time during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-6jd7ps4	Results of Gum Treatment in exercisers and non-exercisers	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6703	Characterization of response to Periodontal Treatment of individuals practitioners and non-practitioners of physical exercise - a quasi-experiment	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6jd7ps4	<NULL>	Recreational CrossFit athletes who perform 3 to 5 workouts weekly; Professional Volleyball athletes; Sedentary patients at the Federal University of Paraná dental clinic; All participants must be systemically healthy and non-smokers, have a body mass index (BMI) of less than 30, and have periodontitis according to the 2018 Classification of Periodontal Diseases	People who have received periodontal treatment in the last 6 months; Present conditions that affect the research such as: diabetes, smoking, pregnant or lactating women; Use of antibiotics, anti-inflammatories, and immunosuppressants within 3 months prior to the study; Alcohol consumption; Use of drugs that can cause gingival hyperplasia; Recreational athletes who train with the main objective of competition performing more than 01 hour per day and exceeding 5 hours per week of training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-8rvtccf	Pain and clinical characteristics following Crown Lengthening: study in smokers and non-smokers	Not yet recruiting	Intervention	2024-01-05	<NULL>	<NULL>	6704	Pain management and clinical characteristics after Gingival Surgery in smokers and non-smokers: randomized controlled trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8rvtccf	<NULL>	Men and women aged at least 18 years; available to participate in all study phases; with a diagnosis of periodontal health in either intact or reduced periodontium; requiring ACC periodontal surgery with a need for osteotomy of at least 1 mm to restore supracrestal structures (periapical radiographs and/or transperiodontal probing will be used to determine the need for osteotomy in these patients); in the non-smoker group, only individuals who report never having smoked or having quit smoking for more than five years will be included; in the smoker group, only individuals who report daily consumption of at least ten cigarettes will be included	Individuals requiring crown lengthening for purely aesthetic purposes; those using any type of orthodontic appliance; individuals with soft or hard tissue tumors in the oral cavity; presence of active infectious foci (endodontic abscesses); chronic use of analgesics or anti-inflammatories for any condition, or use of any analgesics, anti-inflammatories, or chlorhexidine mouthwashes in the seven days preceding the periodontal surgery; this also includes pregnant or lactating; those who have received local or systemic antimicrobial treatment in the last 90 days; individuals requiring antimicrobial prophylaxis for dental treatment; individuals with a history of allergy to paracetamol, ibuprofen, or dipyrone, including their byproducts; a history of allergy to chlorhexidine, including its byproducts; patients with uncontrolled systemic diseases (such as diabetes); patients on anticoagulants or platelet anti-aggregants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-8xk82pt	Study with Electrostimulation on the Skin of the Ankle Region in Children and Adolescents with Bladder Problems due to a Spine Problem	Not yet recruiting	Intervention	2024-01-05	<NULL>	<NULL>	6706	Transcutaneous Electrical Stimulation of the Posterior Tibial Nerve in Children and Adolescents with Neurogenic Overactive Bladder Secondary to Myelomeningocele: Randomized, Double-blind, Placebo-controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	UNiversidade Federal de Minas Gerais	UNiversidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8xk82pt	<NULL>	A sample will be provided for children and adolescents; aged between four and 18 years; diagnosed with refractory Hyperactive Neurogenic Bladder due to myelomeningocele using anticholinergics and a clean intermittent urinary catheter; patients whose parents or guardians agreed to participate in the study after reading, understanding and signing the Informed Consent Form; participants aged six years or over who decided to participate in the study, after reading, understanding and signing the Informed Consent Form.	Children and adolescents with neurogenic bladder due to other neurogenic causes such as spinal tumors, cerebral palsy, spinal cord trauma, among others; patients with underlying medical conditions (metabolic diseases, anorectal and urogenital malformations, previous urogenital surgery such as augmentation cystoplasty or vesicostomy); patients using a pacemaker; patients and/or parents or guardians who did not agree to participate in the study and/or did not agree with the Informed Consent Form and/or Informed Assent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-69pjrtt	Utilization of Clinical Simulation for educating nurses about the Sexuality of the Elderly	Not yet recruiting	Intervention	2024-01-09	<NULL>	<NULL>	6715	Competencies for Addressing Elderly Sexuality: A Simulated Intervention proposal	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-69pjrtt	<NULL>	Nurses working in Primary Health Care	Nurses  who are absent from any stage of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-45vq9cb	Durability of toothbrushes in orthodontic patients: a randomized clinical trial	Not yet recruiting	Intervention	2024-01-10	<NULL>	<NULL>	6717	Durability and efficiency of orthodontic toothbrushes in patients with fixed appliances: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-45vq9cb	<NULL>	Patients in the permanent dentition phase; between 13 and 50 years old; with upper and lower fixed braces; bonded or banded from molar to molar; of both sexes; in good health and with a minimum of 20 permanent teeth, excluding third molars	Patients with active caries; patients with dental development defects; pregnant women; patients with systemic diseases (diabetics or smokers); patients using medications that may affect gingival health (such as calcium channel blockers; cyclosporine and anticoagulants) will be previously excluded; individuals allergic to the plaque discloser and who have limited manual dexterity and cognitive difficulties; cleft lip and palate; syndromes and/or craniofacial anomalies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-82wt6jr	The effect of auriculotherapy in the treatment of pain symptoms, bite force and brain activity in people with changes in the temporomandibular joint	Not yet recruiting	Intervention	2024-01-12	<NULL>	<NULL>	6721	Efect of auriculotherapy by laser biophotomodulation in clinical symptoms, bite force and cortical electrical activity and muscle in people with temporomandibular dysfunction:Crossover randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-30	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-82wt6jr	<NULL>	Both sexes; age above 18 years; diagnosis of temporomandibular disorder	use of ear piercing or birthmark; history of neoplasm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-10ksfmxx	Analysis of strategies for Dental Sensitivity reduction: a medical study	Not yet recruiting	Intervention	2024-01-12	<NULL>	<NULL>	6722	Effects of Glutaraldehyde/HEMA-based products, S-PRG or 980nm Diode Laser on the Dentin Hypersensitivity treatment: a randomized controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10ksfmxx	<NULL>	Participants who have at least one tooth with dentin hypersensitivity, with a score equal to or greater than 4 on the Analogic Visual Scale (VAS). Participants must be aged between 18 and 65. Both genders. Having overall good health. Being available to attend the scheduled appointments and treatment sessions throughout the study period	Individuals with active caries lesions and/or defective restorations on the selected and/or adjacent teeth; structural dentin loss requiring restoration or periodontal treatment; prior use of professional desensitizing agents in the last 6 months; smokers; pregnant individuals; those using anti-inflammatory and/or analgesic medications during the study period - or up to 72 hours before the initial assessment; those who regularly use anticonvulsants, antihistamines, sedatives, and/or anxiolytics; have orthodontic appliances; have a history of or current presence of neoplasms in the head and neck region; or are allergic to any component of the products used in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-5c23n4p	Evaluation of transcutaneous electrical nerve stimulation in patients with cancer pain under palliative care who make chronic use of morphine	Not yet recruiting	Intervention	2024-01-12	<NULL>	<NULL>	6724	Evaluation of low and high frequency transcutaneous electrical nerve stimulation in patients with cancer pain under palliative care who make chronic use of morphine: experimental study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-30	Fundação Pio XII - Hospital de Amor de Barretos	Fundação Pio XII - Hospital de Amor de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-5c23n4p	<NULL>	Patients at least 18 years old; of both sexes; who have neuropathic cancer pain assessed by the Questionnaire for the Diagnosis of Neuropathic Pain (DN-4), Nociceptive or Mixed, with pain intensity classified by Scale Visual Numerical greater than or equal to 4; who make chronic use of morphine, characterized as use more than three months ago	Patients who present inability to communicate verbal or cognitive inability to perform Transcutaneous Electrical Nerve Stimulation (TENS) and non-tolerance within the time proposed therapy; patients with cardiac conditions such as cardiac pacemakers and cardiac arrhythmias; metallic implants at the site of electrode placement;  epilepsy; dermatologic conditions, or skin lesions at the location of the pain that makes it impossible to attach the electrode and history of allergies to conductive gel componentes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-104b9shm	Use of the muscle relaxant Rocuronium in abdominal surgeries by video: comparison between small fractioned doses and continuous infusion	Not yet recruiting	Intervention	2024-01-22	<NULL>	<NULL>	6741	Use of Rocuronium in elective Videolaparoscopic surgeries: comparison between bolus administration and continuous infusion	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital Central do Exército	Hospital Central do Exército	https://ensaiosclinicos.gov.br/rg/RBR-104b9shm	<NULL>	Adults over 18 years old; both sexes; ASA I, II and III - Anesthetic risk classification according to the American Society of Anesthesiologists [ASA1 (patient without comorbidities), ASA 2 ( patient with compensated comorbidities, without functional limitations), ASA 3   (patient with decompensated comorbidities with mild functional limitation.)]; surgery expected to last more than 1 hour	Known allergy to Rocuronium and/or Sugammadex; prior extensive surgery in the surgery cavity; locomotor or neurological disease; gestation; kidney or liver failure; refusal by the patient or his guardian; concomitant use of drugs that are known to interact with Rocuronium according to the manufacturer&apos;s package leaflet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-5tbdpy5	Effect of Mechanical Ventilation Pressure Changes in Obese patients undergoing Laparoscopic Surgery	Not yet recruiting	Intervention	2024-01-29	<NULL>	<NULL>	6751	Effect of ventilatory strategy with Recruitment Maneuvers and PEEP Titration versus ventilatory strategy with Recruitment Maneuvers and 6 cmH2O PEEP versus ventilatory strategy without Recruitment Maneuvers and 6 cmH2O PEEP in Obese patients submitted to Videolaparoscopic Bariatric Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Saullo Queiroz Silveira	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5tbdpy5	<NULL>	"Individuals aged 18 to 65 years old; American Society of Anesthesiologists Physical Status Classification System 2 or 3;
Body mass index ≥ 30 Kg/m2; Elective laparoscopic bariatric surgery; Elective robotic bariatric surgery"	American Society of Anesthesiologists Physical Status Classification System greater than or equal to 4; congestive heart failure; kidney failure; alcohol or drug abuse; allergy to study components; patients undergoing degastrectomy; patients undergoing combined surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-223s4bw	Evaluation of the Laser in Periodontal and Bone Healing in Diabetics	Not yet recruiting	Intervention	2024-01-30	<NULL>	<NULL>	6763	Evaluation of Photobiomodulation in Periodontal and Bone Repair in Diabetic Patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-223s4bw	<NULL>	"Study 1: Participants will be selected according to the following
inclusion criteria: 18 years old, positive diagnosis for Grade B or C periodontal disease, stages 2-4; presence of at least 16 teeth in the oral cavity, with at least 4 non-neighboring sites with a probing depth of 5 mm and bleeding, absence of periodontal treatment one year before the research and not having used antibiotics in the last three months . Study 2: During study 1, patients who consent to participate in study 2 must present the following characteristics: Individuals over 18 years of age; individuals with teeth condemned due to lack of periodontal support; individuals who are indicated for future rehabilitation with an implant (in the region of the units to be extracted); individuals with ASA I or II classification; individuals with the cognitive capacity to maintain their own oral hygiene.”"	"&quot;Study 1: The following will be excluded from the study: pregnant or lactating women, who have periodontal treatment in less than a year, who have used antibiotics in the last three
months, patients using antiresorptive medications.Study 2: The following will be excluded from this study: patients who are metabolically decompensated (ASA classification equal to or greater than III - except diabetics); chronic users of antiresorptive and immunosuppressive medications; patients who present acute periodontitis; heavy smokers (more than 10 cigarettes per day); pregnant and breastfeeding women; history of radiotherapy to the head and neck; have a diagnosis of bruxism; immunosuppressed; teeth with root dilaceration or condition that requires odontosection.”"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-4sv4b8n	Improvement of Anxiety and Stress in Pregnant patients in the practice of the Six Healing Sounds and Conscious Breathing	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6764	Management of Anxiety and Stress in Pregnancy Practice of Six Healing Sounds and Conscious Breathing randomized clinical trial and controlled	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-20	Clínica Cinesiopelvica - CC	Pessoa física responsável Roberta Pitta Costa Luz	https://ensaiosclinicos.gov.br/rg/RBR-4sv4b8n	<NULL>	Criteria pregnant women between 18 and 40 years old;  with a single pregnancy	Diagnosis of psychiatric illnesses: depression and/or anxiety; with pregnancy complications; risk pregnancy; who use mood-moderating medications; who practice yoga, meditation and mindfulness techniques, as they offer satisfactory results in controlling anxiety, it was decided to exclude pregnant women who practice these techniques	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-9r68r8y	Comparison of laparoscopic versus robot-assisted treatment for achalasia	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6765	Comparison of Laparoscopic versus Robot-assisted Cardiomyotomy with Fundoplication for Achalasia treatment: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9r68r8y	<NULL>	Patients with achalasia; patients with indication for surgical treatment (with Eckardt ≥3); age between 18 and 65 years old; male and female sex	Patients who refused to participate in the study; pregnant patients; patients who have any contraindication to general anesthesia or laparoscopic intervention; morbid obesity (BMI&gt;30 kg/m2); patients undergoing previous diaphragmatic hiatus surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-96h3k97	Effects of Electric Current on pain after Breast Augmentation surgery: placebo research protocol	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6769	Effects of Transcutaneous Electrical Nerve Stimulation on the intensity of acute postoperative pain in Breast Augmentation: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Centro de Ciências Biológicas e da Saúde -  Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde -  Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-96h3k97	<NULL>	Women; aged between 18 and 65; Requests for breast augmentation surgery using the 24-hour rapid recovery protocol; report a pain intensity significantly equal to or greater than 3 points on the Numerical Pain Scale in the immediate postoperative period	Chronic diseases; previous experience with electrical currents for pain; history of use of illicit and psychotropic drugs; chronic use of opioids; presence of a cardiac pacemaker; neurological disorders that interfere with the level of consciousness; changes in previous skin sensitivity in the breast; inability to support the shoulder elevated at 90 degrees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-6rrc63n	Effects of Aromatherapy on women with climacteric symptoms	Not yet recruiting	Intervention	2024-02-14	<NULL>	<NULL>	6783	Effects of Aromatherapy with Lippia alba (Mill.) N.E. Brown essential oil on climacteric symptoms: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Susy Maria Feitosa de Melo Rabelo	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6rrc63n	<NULL>	Interest in participating in the study; age between 40 and 65 years; presence of one or more climacteric symptoms, reported from the Blatt and Kupperman Menopausal Index and with moderate to intense intensity; Menopause occurred no more than 5 years ago; Preserved cognitive function, assessed using the Mini Mental State Examination.	Women who have any speech articulation or hearing problems that prevent them from responding to the research instruments and participating in the intervention; Presence of dermatological lesions or considerable deformities in the nose, in addition to already recognized anosmia; Women who have undergone aromatherapy treatment or other PICS in the last month; Women using anxiolytic substances in the last month, such as: benzodiazepines, antihistamines, hypnotics, sedatives, antidepressants, antipsychotics, stimulants and corticosteroids; Women using hormone replacement therapy (HRT) in the last 3 months prior to the intervention; Previous clinical diagnosis of chronic diseases, such as: diabetes mellitus, systemic arterial hypertension, cardiovascular diseases, cancer, seizures, epilepsy and so on, decompensated; Women using antithrombotic medication, as drug interactions with Lippia alba are known; Recognized hypersensitivity after using Lippia alba in other formulations (teas, infusions, creams, lotions, shampoos, etc.); Users of Lippia alba essential oil.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-7b43sfr	Personalized nutrition: dietary intervention to reduce the risk of cardiometabolic diseases using knowledge-based system technology	Not yet recruiting	Intervention	2024-02-15	<NULL>	<NULL>	6788	Precision nutrition: personalized intervention to reduce the risk of cardiometabolic diseases using a knowledge-based system	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-02	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7b43sfr	<NULL>	Volunteers of both sexes; age between 20 and 59 years	Drug users; vitamin and or mineral supplementation; menopausal women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-37qx63d	Assessment of the tolerance and safety of Prescription of different doses of Psilocybin in Healthy adults.	Not yet recruiting	Intervention	2024-02-17	<NULL>	<NULL>	6791	Assessment of the tolerability and safety of Administration of different doses of Psilocybin in Healthy adults.	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2024-05-01	Biocase Brasil	Instituto Alma Viva	https://ensaiosclinicos.gov.br/rg/RBR-37qx63d	<NULL>	Adults without comorbidities aged between 21 and 65 years from both gender	Participants who meet any of the following exclusion criteria are not eligible for the study including use of medications that may interfere with the study drug, history of heart, liver, kidney disease, history of cancer or organ transplant, insulin dependent diabetes or uncontrolled diabetes, gastrointestinal disease that may interfere with the absorption of the substance orally, current or past history of psychiatric disorders as schizophrenia, psychotic disorder, bipolar disorder, personality disorder, first degree family history of psychiatric disorders, seizures or fainting, creatinine elevation, nicotine dependence that would prevent an individual from being nicotine-free for 7 to 10 hours during the dosing period, women who are pregnant or intending to become pregnant during the study or who are currently breastfeeding, chemical dependency or abuse of alcohol or illicit drugs in the last 12 months, platelets disorders,  clinically significant anemia, liver injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-106bhhcy	Trial study of a Treatment of Behavior Change in the practice of walking exercise in people after Stroke	Not yet recruiting	Intervention	2024-02-19	<NULL>	<NULL>	6793	Intervention protocol based on the Theory of Self-Determination on the adherence of individuals after Stroke to the recommendation for walking exercise: A randomized feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-18	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-106bhhcy	<NULL>	Individuals ≥18 years old; ≥ six months after a stroke (ischemic or hemorrhagic); who can understand simple commands, assessed through the Mini Mental State Examination (MMSE) (score greater than 13 points for illiterate, 18 points for low/medium education, and 26 points for others); being able to walk independently with an auxiliary device or not;;having access to smartphone and internet with a minimum volume of 3G	Significant cardiovascular conditions (uncontrolled resting hypertension or uncontrolled metabolic disease); lower limb orthopedic problems that make walking impossible; perform &gt;150 minutes of walking per week on a scheduled basis at moderate intensity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-8fvmt99	Effects of Health Self-Management Strategies on biological, psychological and social aspects of people with Rheumatological Diseases	Not yet recruiting	Intervention	2024-02-20	<NULL>	<NULL>	6795	Effects of a health self-management strategy protocol on biophychosocial aspects of individuals with rheumatological diseases: a single-blinded randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8fvmt99	<NULL>	Volunteers diagnosed with any rheumatological disease; Are not undergoing any type of physiotherapeutic treatment; Older than 18 years; Both genders	History of recent fracture (last 3 months); Have participated in any therapies in the last 3 (three) months; Inability or interruption during functional tests; Perform more than 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity per week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-2kg65g7	Effects of Transcranial Direct Current Stimulation at Different Intensities Associated or Not with Binaural Frequencies on Oxygen Saturation and Reaction Time: Randomized Controlled Study	Not yet recruiting	Intervention	2024-02-23	<NULL>	<NULL>	6801	Effects of Transcranial Direct Current Stimulation at different Intensities associated or not with Binaural Frequencies on Cerebral Hemodynamics and Reaction Time: Randomized Controlled Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Maria de Cassia Gomes Souza Macedo	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2kg65g7	<NULL>	Young adults aged between 18 and 30; with normal hearing; without a history of neuropsychiatric disorders; without the use of psychoactive substances	Participants with metallic materials implanted in or near the head; with pacemakers or cardiac stents; with active devices where interaction with the electrical field may interfere with their operation; individuals with eczema on the head	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-9fkncwv	Clinical monitoring of patients with heart failure	Not yet recruiting	Intervention	2024-02-26	<NULL>	<NULL>	6810	Effectiveness of clinical monitoring in the Transition of patients with Heart Failure between health care networks: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9fkncwv	<NULL>	Adults more than 18 years old; with decompensated heart failure with a minimum left ventricular ejection fraction lower than 40 percent; possibility of access to cell phones to receive video calls	Patients on the heart transplant waiting list; who have undergone surgical or percutaneous treatment (coronary or valve) in the last 3 months and with heart failure considered terminal or in palliative care confirmed in medical records; patients with other serious clinical comorbidities with life expectancy less than 1 year confirmed in medical records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-54s92mh	Free dance versus Hatha Yoga on quality of life and motor and non-motor symptoms in people with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-02-29	<NULL>	<NULL>	6817	The effectiveness of a Free Dance and Hatha Yoga protocol on the motor and non-motor symptoms of people with Parkinson	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-54s92mh	<NULL>	Clinical diagnosis confirmed by a neurologist following the Movement Disorder Society criteria; both sexes; residents of Florianópolis and São José; on stable doses of medication for the last four weeks; on ON medication; aged 45 years or over; not practicing physical exercise in the month prior to data collection; classified in stages 1 to 4 of PD by the Hoehn &amp; Yahr Disability Scale	Cutoff point of the Montreal Cognitive Assessment (MoCA) instrument for screening, considering ≤ 22 points; classified in stage 5 of PD by the HY Disability Scale; who did not complete all stages of the study; who performed other physical exercise concomitantly; who were not present in up to 75% of the classes.date for enrollment of the first participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-86ycwq7	Influence of a Cleaning Agent on the clinical performance of Resin Restorations in endodontically treated teeth: a clinical study	Not yet recruiting	Intervention	2024-02-29	<NULL>	<NULL>	6818	Influence of Katana mt Cleaner on the clinical performance of Bulk Fill Restorations of endodontically treated teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Centro universitário do maranhão-uniceuma	Centro universitário do maranhão-uniceuma	https://ensaiosclinicos.gov.br/rg/RBR-86ycwq7	<NULL>	Participants must be between 18 and 50 years of age; molar with class I and/or II cavity; have an acceptable level of oral hygiene according to the Simplified Oral Hygiene Index (OHI S)19; the cavo-superficial margin cannot involve more than 50% of the tooth enamel; must have two adjacent teeth; presence of the contralateral; the patient accepts the proposed treatment; signed informed consent form	Patients with extremely poor oral hygiene; periodontal index less than 3; xerostomia; orthodontic appliances; intense bruxism; trismus; ankylosis; tooth positioning outside of normal alignment; history of trauma; pregnancy; presence of teeth that require endodontic retreatment; crack in the tooth; existing fractures in the enamel or dentin; tooth support for prosthesis; participants with known allergies to resins or any other material used in the research; patients using anti-inflammatories; analgesics or psychotropic drugs within 15 days of the restorative procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-2vm96f8	Clinical study to verify the best treatment for posterior deciduous teeth: Hall Technique or Resin-Modified Glass Ionomer Cement	Not yet recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6822	Comparison of clinical success between Hall Technique and Resin Modified Glass Ionomer Cement in primary molars: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-05	Bianca Spuri Tavares	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2vm96f8	<NULL>	Children aged 4 to 8; of both sexes; with at least one primary molar affected by interproximal caries affecting dentin and without signs of pulp involvement; Surfaces with obvious carious lesions will be selected and will include ICDAS (International Caries Detection and Assessment System) code 4 underlying dark shade of dentin; 5 ICDAS (International Caries Detection and Assessment System)  distinct cavity with visible dentin; 6 ICDAS (International Caries Detection and Assessment System)  distinct extensive cavity that exposes dentin	Children who present systemic impairment; Children who are allergic to any dental material to be used; Primary teeth that present spontaneous pain or any indication of pulp involvement such as periapical or interradicular lesions; teeth with a history of trauma; teeth whose roots present more than 1/3 of rhizolysis; teeth with carious lesions located below the free gingival margin; teeth with great coronal destruction that do not allow the use of absolute isolation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-9nf6d27	Effects of a digital health education on the knowledge of patients with low back pain about the condition	Not yet recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6825	Effects of an online intervention in patients with low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-15	Universidade do Oeste Paulista - UNOESTE	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9nf6d27	<NULL>	Adults (over eighteen years old); report low back pain without any restriction for duration of symptoms	People unable to understand the Portuguese language; healthcare professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-9tr6hb4	Use of Autolog for cell salvage to prevent complications of blood loss in liposuctions	Not yet recruiting	Intervention	2024-03-06	<NULL>	<NULL>	6834	Use of Autolog system to prevent complications of blood loss in liposuctions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Hospital Agamenon Magalhaes	Hospital Agamenon Magalhaes	https://ensaiosclinicos.gov.br/rg/RBR-9tr6hb4	<NULL>	Patients aged 18 to 60; both genders;  approved by the hospital&apos;s medical board for liposuction	diabetes mellitus; heart problems; vascular diseases; history of previous surgery in the same area; therapy with anticoagulant; replacement with blood products in the last 90 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-4m9yf5k	Effect of probiotics and yoga practice on metabolic syndrome in menopausal women	Not yet recruiting	Intervention	2024-03-06	<NULL>	<NULL>	6837	Effect of Probiotics and Yoga Practice on Metabolic Syndrome in Climacteric Women and assessment of associated epigenetic mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-4m9yf5k	<NULL>	Climacteric women; age between 40 to 65; diagnosis of metabolic syndrome according to the Joint Interim Statement (JIS) criteria	Diagnosis of lactose intolerance or cancer; women who have engaged in yoga practice within the current or past 12 months; women who have used probiotics within the current or past 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-53xtrxx	Vocal behavior and facial of elderly people with Parkinson under the effect of Stimulation Transcranial Direct Current and Photobiomodulation	Not yet recruiting	Intervention	2024-03-07	<NULL>	<NULL>	6840	Randomized clinical trial of vocal behavior and facial of elderly people with Parkinson under the effect of Stimulation Transcranial Direct Current and Photobiomodulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-10	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-53xtrxx	<NULL>	Age group with a minimum age of 65 years; both sexes; diagnosis of Parkinson&apos;s disease at stage 1, 2 or 3 of the Hoehn and Yahr Scale Scale; and without previous speech-language pathology treatment of the voice in the last year with technological resources of Photobiomodulation and Stimulation Transcranial Direct Current (tDCS)	Other associated vocal alterations (detected by previous otorhinolaryngological evaluation); hearing loss; previous acquired brain injuries; general health, cognitive and/or psychiatric conditions that limit the comprehension or performance of the tasks to be performed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-3cdtw97	Modified Laser Intravascular Blood Irradiation in women with Breast Cancer: clinical trial	Not yet recruiting	Intervention	2024-03-11	<NULL>	<NULL>	6843	Effects of Modified Laser Intravascular Blood Irradiation in women with Breast Cancer: randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Paraná	Liga Paranaense de Combate ao Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3cdtw97	<NULL>	Women over the age of 21; with a clinical diagnosis of unilateral or bilateral primary breast cancer; undergoing conventional adjuvant antineoplastic treatment (chemotherapy, radiotherapy or hormonal therapy); whether or not undergoing surgical treatment to remove the solid tumor; with a score between 0 to 2 on ECGO-OS (Eastern Cooperative Oncology Group Performance Status); with the ability to communicate in Portuguese; residing in Curitiba or the Metropolitan Region; available to participate in research interventions in a 10-week follow-up schedule	Women under 21; who do not agree to participate in this study; illiterate or who present cognitive deficit determined by the MMSE questionnaire - Mini Mental State Examination; hearing deficit that prevents understanding verbal instructions; with the presence or suspicion of metastatic areas, presence of allergies or skin diseases (atopic dermatitis, contact dermatitis, psoriasis or rosacea); pregnant or lactating women; women with a body mass index (BMI) above 40 (due to the presence of comorbidities related to obesity that may interfere with the results); contraindications for the application of mILIB will (cardiogenic shock, arterial hypotension, heart disease, circulatory failure in stages II and III, anemia, sick sinus syndrome, existence of blood coagulopathies, personal history of cancer at the application site); hemorrhagic, infected or photosensitive area; women with phototype VI on the Fitzpatrick scale confirmed by the analyzer as phototype V; blood tumors; pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-10rmznpy	Determination of the progression of Erosive Tooth Wear by two Clinical Methods	Not yet recruiting	Observational	2024-03-12	<NULL>	<NULL>	6850	Validation of two methods of Detection and Clinical Measurement of Erosive Tooth Wear: A prospective Cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	https://ensaiosclinicos.gov.br/rg/RBR-10rmznpy	<NULL>	To be at least 18 years old; have good oral health; present at least one of the conditions: with diagnosis of gastroesophageal reflux disease, receiving medical treatment or taking over the counter medication for gastroesophageal reflux disease, having heartburn episodes, sour taste in the mouth at least twice a week; having recurrent vomiting; daily consumption of acidic foods and drinks	Active caries lesions or defective restorations; pregnant or breast feeding; subjects with denture; subjects under orthodontic treatment; being in another research in the same period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-3tvtfzq	Cardiopulmonary Resuscitation Learning Program for school-age children	Not yet recruiting	Intervention	2024-03-15	<NULL>	<NULL>	6857	The social impact of the Cardiopulmonary Resuscitation Learning Program for school-age children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Centro Universitário Faculdade de Medicina ABC	Centro Universitário Faculdade de Medicina ABC	https://ensaiosclinicos.gov.br/rg/RBR-3tvtfzq	<NULL>	500 children and their respective teachers will be invited to participate in the research. All students from the second to fifth year of Elementary School I and the sixth and seventh year of Elementary II regularly enrolled in educational institutions participating in the research will be included	All students who do not sign the Informed Assent Form (TALE - Annex A) and parental consent form (Annex B), in addition to the authorization signed by the parents (Annex C) will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9tfcwh4	Impact of physical exercise on the Heart Rate of patients after cardiac surgery	Not yet recruiting	Intervention	2024-03-18	<NULL>	<NULL>	6863	Impact of combined physical exercise on Heart Rate Variability of patients after Cardiac Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Maranhão	Hospital Dr. Carlos Macieira	https://ensaiosclinicos.gov.br/rg/RBR-9tfcwh4	<NULL>	adult patients; in the postoperative period of cardiac surgery; over 18 years of age and under 70 years of age; both sexes; who are on the first postoperative day; who have the cognitive capacity to understand the research process, by signing the Free and Informed Consent Form	have diseases or some type of musculoskeletal disability; bone or joint disorders that make assessments and exercise protocol impossible; mechanical ventilation; neurological and behavioral changes; patients with hematocrit lower than 30%; hemoglobin less than 7; severe lung conditions; pathologies that incapacitate the study, such as amputation of the upper limbs or lower limbs; amaurosis; deep vein thrombosis; patients who were already performing aerobic or resistance exercise;  participants who have unstable angina; decompensated cardiac arrhythmia; interaction difficulties that are unable to answer the questionnaires; systolic blood pressure greater than or equal to 160 mmHg; diastolic blood pressure greater than or equal to 100 mmHg recurrent in 3 sessions; mediastinitis; decompensated diabetes mellitus; fasting blood glucose greater than 300; acute systemic infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-87dk5nk	Online refraction exam	Not yet recruiting	Observational	2024-03-19	<NULL>	<NULL>	6869	Online Refraction Test vs. manifest subjective refraction: Non-Inferiority Clinical Trial	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-25	Eyecare Health	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-87dk5nk	<NULL>	Healthy volunteers. Aged between 18 and 40 years. With no history of ocular diseases or current evidence of serious ocular conditions	Participants with refractive error greater than 6 diopters (myopia or hypermetropia), astigmatism greater than 3.00 diopters, antimetropic anisometropia. Diabetes. Pregnancy. Lactation. History of previous ophthalmic surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-2tq2jky	Multicomponent exercises in older adults - VIVIFRAIL®	Not yet recruiting	Intervention	2024-01-22	<NULL>	<NULL>	6878	Effect of multicomponent exercises on the intrinsic functional capacity of older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-25	Pontifícia Universidade Católica do Rio Grande do Sul	Fundação de Assistência Social e Cidadania- FASC	https://ensaiosclinicos.gov.br/rg/RBR-2tq2jky	<NULL>	Older individuals of both genders; aged at least 60; who regularly attend meetings of elderly groups at the Foundation of Social Assistance and Citizenship; who do not have severe visual, auditory, or cognitive impairment that would hinder the safe completion of the proposed assessments or exercises	Participants who have surgeries or scheduled procedures in the next eight months that would prevent them from participating in the exercise program; participants who cannot remain seated without support for at least 10 minutes during the functional assessment; participants who, during the cognitive assessment, demonstrate an inability to respond to verbal commands; exclusion criteria for the VIVIFRAIL® exercise protocol: Acute myocardial infarction or recent unstable angina within 6 months; recent report of uncontrolled atrial or ventricular arrhythmias within 30 days; history of dissecting aortic aneurysm; severe aortic stenosis; acute endocarditis/pericarditis; uncontrolled high blood pressure; acute thromboembolic disease; severe acute heart failure; severe acute respiratory failure; uncontrolled orthostatic hypotension; acute decompensation of diabetes mellitus or uncontrolled hypoglycemia; recent fracture within the last month; any other circumstance that is considered a hindrance or risk for engaging in physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-103g8nwg	Effects of a single session of Physical Exercise performed in Immersive Virtual Reality and Exergame in young adults subjected to Unpleasant Stimulus	Not yet recruiting	Intervention	2024-03-22	<NULL>	<NULL>	6886	Comparison of the physiological and psychobiological effects of a single session of Physical Exercise carried out in Immersive Virtual Reality and Exergame in young adults subjected to Unpleasant Stimulus	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-103g8nwg	<NULL>	Do not exercise regularly and do not have significant visual impairment (i.e., everyone with normal or corrected-to-normal visual acuity)	Present contraindication to carrying out physical activity; people on their menstrual period; have a diagnosis of mood or anxiety disorders; be using any type of psychotropic drug; have abusive use or dependence on alcohol or tobacco; report some type of labyrinthopathy (Benign Paroxysmal Positional Vertigo, Ménière&apos;s Disease, Labyrinthitis, etc.); not answering any study question; discontinuity of tests; and not being literate (due to the need to respond to questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-10bqkrcw	Dental and periodontal manifestations in individuals with occlusal overload	Not yet recruiting	Observational	2024-03-22	<NULL>	<NULL>	6888	Occlusal pathologies in individuals with occlusal overload	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10bqkrcw	<NULL>	Voluntary individuals; toothed; without specific complaints; of both sexes; aged 18 years or older; to read and agree to the Informed Consent Form	Individuals who do not have a compatible smartphone to respond to the required questionnaires; wearers of full or partial removable dentures in one or both arches; with fixed protocol-type prostheses; in orthodontic treatment or still in upper retainer use; with iodine allergy; with active periodontal disease; using an occlusal splint; using a mouthguard; on continuous Selective Serotonin Reuptake Inhibitor (SSRI) medication; with special needs; pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-6hmfkgs	Elastographic analysis of the muscle after the application of thermal therapies.	Not yet recruiting	Intervention	2024-03-26	<NULL>	<NULL>	6895	Elastographic analysis of muscle tissue in healthy subjects after interaction with thermal resources	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-10	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6hmfkgs	<NULL>	Healthy volunteers; Aged between 18 and 30 years old.	Present neuromuscular injuries involving the knee extensor muscles; Present thermal sensitivity disorders; Have performed exercises with load on the lower limbs in the last 72 hours; Have ingested caffeine and energy drinks 24 hours before the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-4d7kgrw	An internet-delivered pain and exercise education program for low- and middle-income individuals with back pain	Not yet recruiting	Intervention	2024-04-02	<NULL>	<NULL>	6907	Efficacy and equity of exercise combined with Education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-04	Universidade Federal dos Vales de Jequitinhonha e Mucuri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4d7kgrw	<NULL>	Patients over the age of 18 who have had nonspecific low back pain for at least 3 months; able to read and understand Portuguese; have access to the internet	Suspected or confirmed severe spinal pathology; fracture; metastatic diseases; inflammatory or infectious diseases of the spine; generalized neurological disorder; previous history of spine surgery in the last 12 months; pregnancy; and contraindications to exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-10xvvn39	Mixture of green banana pulp and peel flour: use in the production of functional foods and effect on the health of overweight people	Not yet recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6909	Mixed prata green banana pulp and peel flour: potential application in the development of functional foods, and impact on intestinal health and metabolic changes in individuals with obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-26	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-10xvvn39	<NULL>	women between 20 and 55 years of age; body mass index 27 and &lt;30 kg/m²; high waist circumference (80 cm); excess body fat (&gt; 30% for women) associated with at least one other component of metabolic syndrome: triglycerides 150 mg/dL or blood pressure 30/85 mmHg) or fasting glycemia fasting blood glucose 100 mg/dL/HgA1&gt;57% or HOMA-IR&gt;3.2 (fasting blood glucose/insulin) who is taking medication to control these markers; or obesity (BMI &gt;= 30 kg/m²); high waist circumference ( 80 cm for women) and excess body fat (&gt; 30% for women) regardless of the presence of the other components of the syndrome	women aged &lt; 20 years or &gt; 55 years; BMI&lt;27 kg/m²; absence of at least one other component of metabolic syndrome; waist circumference &lt; 80 cm; body fat percentage &lt; 30%; consumers; pregnant women; lactating or menopausal or climacteric with or without hormone replacement; athletes; vegans; patients with a history of HIV; digestive diseases or changes; hepatic; renal; cardiovascular; thyroid; Cancer; inflammatory diseases and eating disorders; history of drug and/or alcohol abuse; infectious episode in the last month; I have not had COVID in the last 6 months; use of antiinflammatory medications, corticosteroids, antibiotics and others that may affect appetite and energy metabolism; weight instability without weight (5% of usual weight) in the last 3 months; alcohol consumption &gt; 21 units (168g) per week; aversion or intolerance to foods provided in the study; consumption of dietary supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-34dc8f4	Effect of physical training associated or not with Whole-Body Electromyostimulation at elderly people survivors of COVID-19	Not yet recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6910	Effect of physical training associated or not with Whole-Body Electromyostimulation in Functional, Vascular and Autonomic variables of elderly people survivors of COVID-19: controlled clinical trial and randomized	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2024-06-17	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-34dc8f4	<NULL>	Elderly people of both sexes; aged over 60 years; positive diagnosis for COVID 19 according to the test at least 2 months before being included in the exercise protocol; classified with Post COVID 19 Functional Status Scale greater than 2; volunteers who tested positive for COVID 19 and were isolated at home; as per WHO guidance; elderly people who required hospitalization due to COVID 19 after 30 days of hospital discharge as previously recommended and who present post COVID 19 syndrome; patients with persistent symptoms of fatigue and dyspnea within 1 to 3 months after confirmed diagnosis of COVID 19	Volunteers with orthopedic or neurological impairments that prevent participation in a physical exercise program; myocardial infarction; within six months of the beginning of the study; implanted pacemaker or any metallic synthesis; history of heart disease; unstable angina; arterial hypertension controlled; uncontrolled or insulin dependent diabetes mellitus and participation in a regular physical exercise program at the beginning of the study; hospital admission less than 72 hours ago; volunteers will also be excluded if they present hypersensitivity to electrical stimulation; chronic obstructive pulmonary disease;heart failure; asthma; previous tuberculosis; bronchitis; lung cancer; a condition that may compromise the performance of functional tests, documented diabetic neuropathy; cognitive deficit; difficulty understanding or adherence to study procedures; declared users of illicit drugs; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-10mc9dwz	Evaluation of the use of Membranes incorporated with Ozonized Oil in the healing of Extraction Surgery of lower third molar teeth: randomized, split-mouth, prospective, double-blind clinical trial	Not yet recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6915	Evaluation of the use of Nanofibers incorporated with Ozonized Oil in the healing of lower third molar extractions: randomized, split-mouth, prospective, double-blind clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-06-15	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10mc9dwz	<NULL>	Adult patients aged 18 to 59 years; of both sexes; without problems systemic; with semi-retained teeth 38 and 48 indicated for extraction	Patients with fully erupted lower third molars; patients with diseases such as hypertension; diabetes and syndromes; pregnant patients; patients with diagnosis of platelet problems; smokers or alcoholics; patients under 18 years of age and over 59 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-86bzhkv	Electrical Nerve Stimulation associated exercises in patients with low back pain	Not yet recruiting	Intervention	2024-04-05	<NULL>	<NULL>	6921	Low-frequency Transcutaneous Electrical Nerve Stimulation associated stabilization exercises in pain in patients with non-specific chronic low back pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-86bzhkv	<NULL>	Men and women; between 18 and 60 years of age; body mass index between 18.5 and 30 kg/m2; non-specific low back pain for at least 12 weeks and pain at least 3 on Visual Analog Scale -  VAS; without prior contact with any electrotherapy current; absence of red flags such as - fracture, infection, tumor, inflammatory arthritis, pain with radicular characteristics, spondylolisthesis and spinal canal stenosis; without previous surgeries in the lumbar spine; no chronic use of analgesic opioids; no skin changes or changes in sensitivity at the application site; without pregnancy and pacemaker use	Participants who start using analgesics that modulate the primary outcome during treatment; accidents that prevent the exercise protocol; pregnanc; death and change of residence from the study state	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-26ymzkc	Pulverize Yam (D. Cayennensis) supplementation in the treatment of Gestational Diabetes Mellitus	Not yet recruiting	Intervention	2024-04-08	<NULL>	<NULL>	6925	Therapeutic perspective of Gestational Diabetes Mellitus with Yam Pulverize supplementation (D. Cayennensis)	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-26ymzkc	<NULL>	Voluntary pregnant women with Gestational Diabetes Mellitus treated at the Lauro Wanderley University Hospital; over age	Pregnant women who are allergic to yams will be excluded; patients with kidney diseases; patients with liver or neurological diseases; pregnant women using multiple medications; minors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-5q5g4s6	Analysis of biceps and triceps brachii muscle activity during elbow flexion and extension movements using Pilates breathing with different loads: a clinical trial	Not yet recruiting	Intervention	2024-04-10	<NULL>	<NULL>	6929	Electromyographic analysis of the biceps and triceps brachii muscles during elbow flexion and extension movements using the Pilates method breathing technique in different load settings: a clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5q5g4s6	<NULL>	Participants must be healthy individuals of both sexes; aged between 18 and 25 years; with no experience with the Pilates method	Participants who do not sign the informed consent form; who cannot attend a second data collection session; who are unable to perform the Pilates method technique; who cannot remain in an upright position; who are unable to perform flexion and extension movements of the curves; who have undergone surgical procedures that prevent the protocol from being performed; who have recent injuries in the elbow region; who show signs and symptoms of inflammation; who have a high degree of muscle imbalance between the upper limbs; who have serious neurological, cardiorespiratory, or metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-10242sbz	Effect of intraoral and extraoral Photobiomodulation Therapy in the treatment of oral mucosal diseases	Not yet recruiting	Intervention	2023-01-18	<NULL>	<NULL>	6930	Intraoral and extraoral Photobiomodulation Therapy in the treatment of common oral mucosal diseases: basket trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2023-07-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10242sbz	<NULL>	volunteers; diagnosed with oral lichen planus or burning mouth syndrome; treatment-naive; both genders; minimum age of 18 years	patients with oral lichen planus diagnosed with gastrointestinal ulcer; decompensated systemic arterial hypertension and/or decompensated diabetes mellitus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-4s62j8t	Factors associated of Influence on Tinnitus	Not yet recruiting	Observational	2024-04-15	<NULL>	<NULL>	6933	Factors associated with the level of Somatosensory influence on Subjective tinnitus	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4s62j8t	<NULL>	Both genders; age between 18 and 60 years old; with tinnitus	Under 18 years old; over 60 years old; cognitive difficulty; degenerative neurological disease; moderate to severe hearing loss; history of psychiatric hospitalization; volunteers who bring information considered dubious; volunteers who withdraw their consent to participate; who develop some of the conditions foreseen in the non-inclusion criteria or another medical condition judged by the investigator as impeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-77sqd4z	Study with cancer patients followed at the Cecon Foundation Pain Therapy and Palliative Care Service to analyze whether a Meditation intervention using Virtual Reality glasses will alleviate Pain and improve patients&apos; quality of life	Not yet recruiting	Intervention	2024-04-15	<NULL>	<NULL>	6939	Study with cancer patients followed at the Pain Therapy and Palliative Care Service of Fundação Cecon: an analysis of quality of life and the impact of a Meditation intervention with Immersive Virtual Reality for pain relief	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-11	Fundação Centro de Controle de Oncologia do Estado do Amazonas - FCECON	Fundação Centro de Controle de Oncologia do Estado do Amazonas - FCECON	https://ensaiosclinicos.gov.br/rg/RBR-77sqd4z	<NULL>	Be monitored at the  Pain Therapy and Palliative Care Service (STDCP) to control symptoms arising from any type of neoplasia at any stage; a diagnosis of chronic pain recorded in the medical record; both genders, male and female; be between 18 and 75 years old on the date of the first collection; able to understand Portuguese (read and write); normal vision and hearing; have an Android cell phone; able to perform movements with the head and with sufficient motor control to perform body movements; agree to participate in the study and sign the Free and Informed Consent Form (ICF)	Patients of the indigenous race, due to cultural, linguistic peculiarities and legislation special; patients with records of serious psychiatric illnesses in the medical record from Diagnostic and Statistical Manual of Mental Disorders  (DSM-5), schizophrenia, schizotypal disorders, delusional disorders, borderline and dementia; impairment of the ability to understand or communicate based on the researcher&apos;s assessment; report of discomfort with the use of Immersive Virtual Reality; progression of the disease with the limitation of maintaining the proposed regular outpatient return; patients with brain tumors, brain metastases, or past history of seizures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-7v33r6x	Assessment of the impact of using more affordable Videolaringoscopes in airway management	Not yet recruiting	Intervention	2024-04-16	<NULL>	<NULL>	6940	Evaluation of the impact of the use of 3d printed Videlaryngoscopes on airway management	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-10	Hospital Santa Izabel - Santa Casa da Misericórdia da Bahia / Professor Doutor Celso Figueirôa	Instituto de Ensino e Simulação em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7v33r6x	<NULL>	Doctors participating in the advanced cardiology life support course at Health Education and Simulation Institute; who agree to the study and sign the Free and Informed Consent Form	Refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-1034kxcw	Effect of Respiratory Muscle Training on respiratory muscle strength and exercise resistance in patients with Acute Heart Failure in the hospital phase of cardiac rehabilitation	Not yet recruiting	Intervention	2024-04-18	<NULL>	<NULL>	6951	Effect of Inspiratory Muscle Training on Inspiratory Muscle Strength and Exercise Resistance in a Patient with Acute Heart Failure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-24	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-1034kxcw	<NULL>	Patients diagnosed with heart failure; ventricular ejection fraction less than 40 percent; aged greater than or equal to 18 years; hospitalized for decompensated heart failure and clinically stable without the need for continuous ventilatory support	Decompensated lung diseases, pregnancy, head trauma, brain injury, cognitive impairment, neuromuscular disorders, hemodynamic instability with high dose of inotropes or acute coronary syndrome, presence of physical limitation that limits the performance of assessments and those who do not agree to sign the term of free and informed consent. Hemodynamic instability will be considered if systolic blood pressure is less than 90 mmHg or mean arterial pressure is less than 65 mmHg, peripheral hypoperfusion, heart rate is less than 40 or greater than 130 beats per minute, SpO2 is less than 88%, recent episodes of vomiting, complaints of dizziness or headache, high dose of dobutamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-3gpm324	The effect of Zumba and electronic movement games on Anxiety levels	Not yet recruiting	Intervention	2024-04-22	<NULL>	<NULL>	6956	The influence of Zumba through the Exergame compared to the traditional form on the Anxiety	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-3gpm324	<NULL>	Young people of both sexes; aged between 18 and 39 years old; have anxiety according to the State-Trait Anxiety Inventory questionnaire	Participants who have a low level of anxiety;  participants that use any type of anxiolytic or antidepressant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-10ch623r	The first 6 months of life of newborns assisted with Preemietest equipment	Not yet recruiting	Observational	2024-04-24	<NULL>	<NULL>	6959	Morbidity in the first 6 months of life of newborns assisted with the Preemietest equipment: a cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-01	Birthtech Dispositivos para a Saúde Ltda	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-10ch623r	<NULL>	NB from mothers; and the mothers themselves; and who delivered the baby; between the likely period of October 2023 to October 2024 (after ethical approval); in Units assisted with Preemiertest equipment	Malformation with structural changes to the skin; skin modifiers: anhydramnios; dropsy; congenital skin diseases or chorioamnionitis; newborns with congenital heart defects; patent ductus arteriosus; tachypnea not due to prematurity; and newborns with a clinical or laboratory diagnosis of infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-2cr7h9f	The Effects of Photobiomodulation in children with autism: a randomized controlled clinical trial	Not yet recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6963	Effect of Photobiomodulation In children with Autism Spectrum Disorder: a randomized and controlled clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-05-06	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2cr7h9f	<NULL>	Children aged between 3 and 12 years; both sexes; diagnosed with Autistic Spectrum Disorder, regardless of the degree of severity, gender, race, ethnicity or type of treatment they are undergoing	Are undergoing medical treatment and using medications for non-Autism Spectrum Disorder-related pathologies (e.g., diabetes, cancer, epilepsy). Have any comorbidity that prevents the use of Photobiomodulation (photosensitivity or other conditions).  Discontinue the ongoing conventional multiprofessional treatment at Comprehensive Care Program for Children and Adolescents - PAICA or initiate a new treatment during the study. Have had an unstable medical condition in the last thirty days. Interrupt the treatment for more than one week or miss more than two Photobiomodulation sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-10gjt53p	Effect of online Psychotherapy on the quality of life of old people	Not yet recruiting	Intervention	2024-04-26	<NULL>	<NULL>	6971	Effectiveness of online Systemic Relational Psychotherapy for the quality of life of old people: clinical trial randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-10gjt53p	<NULL>	Age between 60 and 80 years old; low quality of life in WHOQOL-bref; mild to moderate depressive symptoms on the GDS-15; access to the internet and digital technologies; live in the northern region of Rio Grande do Sul	Functional and/or cognitive impairment; hearing impairment; in psychotherapy; illiterate; failure to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-10qgbdg3	Effect of Two Procedures for Dressing the Roof of the Mouth Evaluating Pain, Quality of Life and Healing in People Who Underwent Gum Grafting	Not yet recruiting	Intervention	2024-04-28	<NULL>	<NULL>	6974	Effect of different protective interventions of the palatal donor area on Healing, Pain and Quality of Life of individuals undergoing Epithelized Free Gingival Grafts: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal de Minas Gerais (UFMG)	Universidade Federal de Minas Gerais (UFMG)	https://ensaiosclinicos.gov.br/rg/RBR-10qgbdg3	<NULL>	Individuals aged 18 or over; systemically healthy or controlled American Society of Anesthesiologists (ASA) (ASA I / ASA II); with minimum palatal tissue thickness 2mm assessed with a University of North Carolina (UNC) periodontal probe; both genders	Smokers and alcoholics; individuals with altered coagulation, i.e., history of hemophilia, von Willebrand disease, or currently undergoing anticoagulant therapy; individuals with altered healing patterns, that is, decompensated type 2 Diabetes Mellitus; pregnant and breastfeeding women; individuals with a history of bacterial endocarditis; with continuous use of anti-inflammatories and corticosteroids; individuals who underwent gum grafting in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-10htn4xy	Effect of Dry Needling on the psychoacoustic characteristics of Somatosensory Tinnitus	Not yet recruiting	Intervention	2024-04-30	<NULL>	<NULL>	6979	Somatic Tinnitus and Trigger Points	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10htn4xy	<NULL>	Over 18 years old; both sexes; constant or intermittent tinnitus, uni or bilateral and chronic; tinnitus must be perceptible at the time of the evaluation, in the in case it&apos;s intermittent; modulation of tinnitus during muscle palpation, at least in one trigger point	Patients with alterations and/or systemic diseases not controlled; patients with diseases of the central nervous system; Patients undergoing treatment using ototoxic medications; Patients with a history of alcohol and/or drug abuse; Patients afraid of needles; patients receiving dry needling treatment previously; patients with impaired language or cognition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-5jy7kzj	Use of music with the objective of reducing anxiety in patientes who will have coronary angioplasty	Not yet recruiting	Intervention	2024-05-09	<NULL>	<NULL>	6998	Music in anxiety and stress in patientes who will undergo transluminal coronary angioplasty: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Rodrigo Assis Neves Dantas	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-5jy7kzj	<NULL>	Patients aged 18 years or over; patients undergoing angioplasty for the first time; patients scheduled on an outpatient basis; absence of the use of sedatives or anxiolytics; possibility of assessment with anxiety and stress scales	Patients with neurological problems; patient with hearing impairment; using anxiolytic medication or antidepressant drug; don&apos;t like music	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-9xhn6qn	Effect of physical exercise on functional capacity, muscle strength and quality of life in patients with liver cirrhosis	Not yet recruiting	Intervention	2024-05-10	<NULL>	<NULL>	6999	Effect of physical exercise program on functional capacity, peripheral muscle strength, respiratory muscle strength and quality of life in patients diagnosed with liver cirrhosis: randomized controlled experiment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-9xhn6qn	<NULL>	Patients diagnosed with liver cirrhosis with Child A classification; both sexes; minimum age of 18 years and undergoing clinical monitoring	volunteers with encephalopathy from grade 2 (through clinical diagnosis); who had esophageal varices in the last 6 months (through clinical diagnosis); volunteers who have respiratory pathologies and/or associated musculoskeletal pathologies (through medical diagnosis prior to the research); and exercisers for at least 3 months (self-report)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-6sz8zht	A clinical study to investigate the effects of oral immunonutrients during the perioperative period of patients with gastrointestinal cancer	Not yet recruiting	Intervention	2024-05-10	<NULL>	<NULL>	7000	Effects of enteral supplementation with immunonutrients in the perioperative course of patients with cancer of the gastrointestinal tract: A double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-6sz8zht	<NULL>	Patients aged over 18 years will be included; with anatomopathological examination that shows any histological type of cancer of the gastrointestinal tract; who will undergo any curative and elective surgical procedure	Pregnant women will be excluded; people submitted to the use of artificial nutrition in the 15 days prior to inclusion in the study; people allergic to any components of the diet; people with any gastrointestinal diseases prior to the malignancy; people with immunosuppression or using immunosuppressive therapies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-10v99xgj	Effects of Multicomponent Physical Exercise and Auriculotherapy in the elderly	Not yet recruiting	Intervention	2024-05-13	<NULL>	<NULL>	7002	Effects of a Physical Exercise protocol Multicomponent and Auriculotherapy in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-13	Universidade Comunitária da Região de Chapecó	Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-10v99xgj	<NULL>	Physiotherapeutic and/or medical diagnosis of chronic low back pain; (2) age group between 60 and 75 years old and of both sexes; preserved cognitive, assessed by the Mini-exam Mental State; chronic low back pain, defined as a complaint of pain in the lumbar region below the twelfth thoracic vertebra, with or without irradiation, lasting more than six months and with a moderate to intense degree of intensity, tested by the Visual Analogue Pain Scale	Missing two consecutive sessions of intervention or three interspersed; (2) carrying out acupuncture treatment in the last six months; undergoing physiotherapeutic treatment in the last three months; have neurological injuries or disorders that compromise walking and execution of exercises; have tumors or are undergoing cancer treatment; present bone or marrow infections and ankylosing spondylitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-3xsnft5	Comparison of healing and pain after surgery to remove a gingival graft from the palate protected by light-cured fluid composite resin and cyanoacrylate-based tissue adhesive	Not yet recruiting	Intervention	2024-05-14	<NULL>	<NULL>	7003	Comparative analysis of healing and posoperative pain in donor sites of free gingival graft protected with flowable resin composite and cyanoacrylate tissue adhesive	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-3xsnft5	<NULL>	To be 18 or over; do not report the presence of systemic diseases; present healthy periodontium and periodontal stability after conventional periodontal therapy; present a plaque and bleeding index on probing &lt; 10% of sites; needing periodontal plastic surgery using a deephelialized free gingival graft (EGL-d) to treat single and multiple gingival recessions (Class I and II of Cairo, 2011) in the mandible or anterior region of the maxilla (canine to canine); no previous history of palatal graft removal	Pregnancy; report use of medication that may have an adverse effect on periodontal tissues; inadequate endodontic treatment; tooth mobility at the surgery site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-10cqv83n	Application of myofascial release aiming to prevent injuries in athletes	Not yet recruiting	Intervention	2024-05-15	<NULL>	<NULL>	7007	Myofascial release and injury prevention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10cqv83n	<NULL>	Participants must practice Taekwondo at least twice a week for two cycles; have at least 12 years old; both genders	To perform some preventive monitoring within the practice of the sport; already be injured at the beginning of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-2bd7gnb	The long-term effects of Betaine supplementation on Cholesterol, Blood Sugar levels, Body Measurements, Cardiovas-cular Health, and Exercise Habits in adults who engage in Weightlifting	Not yet recruiting	Intervention	2024-05-16	<NULL>	<NULL>	7009	Chronic effects of Betaine supplementation on Lipid and Glycemic profile, Anthropometric and Cardiovascular parame-ters, and on Physical Exercise practice in adults engaged in Weightlifting: a randomized, double-blind, placebo-contro-lled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2bd7gnb	<NULL>	Male individuals; practicing physical activity; within the age range of 35 to 55 years; who have been engaged in weightlifting for a minimum of 6 months; exercising for at least 30 minutes, 3 times a week; willing to be evaluated by a nutritionist; agreeing to be supervised by a fitness professional who will determine and oversee their weightlifting training; and committing to at least 9 days of training during the study period under the supervision of the fitness professional	Smokers; individuals with any reported chronic diseases such as cardiovascular diseases, metabolic syndromes, pulmonary diseases, and renal diseases; individuals with orthopedic problems and/or muscular or orthopedic injuries; individuals using any type of steroids, supplements, or herbal remedies; individuals with needle phobias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10gm45rd	Assessment of skin irritability after using a medical device	Not yet recruiting	Intervention	2024-05-16	<NULL>	<NULL>	7011	ORC_95616_EN23-0748-01_Assessment of primary dermal irritability, cumulative dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-10gm45rd	<NULL>	Participants of both sexes aged 18 to 70; phototype: I, II, III and IV; skin in the application region is complete; agreement to follow the trial procedures and attend the clinic on the specified days and times; understanding, consent and signature of the free and informed consent form	Pregnancy or risk of pregnancy and/or lactation; use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; expect intense exposure to sunlight or tanning sessions during the study period; provision for bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; vaccination scheduled during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitization to topical products; active skin pathologies that may interfere with the study results; skin reactivity; use of new medications/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient of the study product; history of lack of adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or an immediate family member of an employee involved in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-3njdgg4	Effects of Auriculotherapy on Stress in healthcare workers	Not yet recruiting	Intervention	2024-05-24	<NULL>	<NULL>	7023	Effects of Auriculotherapy on subjective and objective Stress in healthcare workers: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade do Estado da Bahia - Departamento Ciências da Vida	Universidade do Estado da Bahia - Departamento Ciências da Vida	https://ensaiosclinicos.gov.br/rg/RBR-3njdgg4	<NULL>	Volunteers with salivary cortisol and perceived stress levels above the general average; workers from Family Health Units; both genders; age between 18 and 70 years	Pregnant women; workers using antidepressants; bleeding oral lesions; treatment with auriculotherapy by other means	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-2fr644j	Low-cost 3D-printed device for the Assessment and Training of Respiratory Muscles in the elderly	Not yet recruiting	Intervention	2024-05-24	<NULL>	<NULL>	7025	Use of a low-cost 3d printed Prototype in the Assessment and Training of the Respiratory muscles of elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-04	Instituto de Ciências da Saúde - Universidade Federal da Bahia	Instituto de Ciências da Saúde - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-2fr644j	<NULL>	Be 60 years of age or older; score from 1 to 5 on the visual frailty scale; score at least 19 points in the Mini-Mental State Examination (MMSE), if you are not illiterate, 23 points if you have 1 to 3 years of schooling, 24 points for 4 to 7 years of schooling and for more than 7 years of schooling , 28 points.	Having decompensated musculoskeletal and neurodegenerative diseases, chronic diseases (hypertension, diabetes mellitus, chronic pain); unstable cardiovascular and pulmonary diseases (acute heart failure, recent myocardial infarction, unstable angina, uncontrolled arrhythmias, asthma, among others) that make it impossible to practice the training protocol; smokers/smokers; practice or have practiced a pulmonary rehabilitation program in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-5x936hn	Efficacy of a new intervention in the control of non-allergic Rhinitis: a randomized controlled trial	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7026	Efficacy of cold bath as an intervention in the control of non-allergic Rhinitis: a randomized and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	M A Fornazieri Servicos Medicos (nome fantasia Clínica Olfact)	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5x936hn	<NULL>	Participant aged between 18 and 55; have negative specific IgE (data from medical records) or negative Prick test (allergic skin test carried out at the Olfact Clinic); being diagnosed with non-allergic rhinitis	Have a history of allergy or hypersensitivity to budesonide; participant with a history of traumatic brain injury, due to the risk of neurological damage in association with hyposmia/anosmia; participants with acute or chronic rhinosinusitis; participant with a history of post-infectious olfactory loss; participants with neurodegenerative diseases, due to the high association with hyposmia/anosmia; participants with heart disease; participants with uncontrolled hypertension, asthma or chronic bronchitis; participants who are unable or unwilling to sign an Informed Consent Form or comply with the study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-48gcrk8	Effects of Brain Stimulation on Anxiety, Inhibition Control and Risk taking behavior in young university students	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7029	Effects of Transcranial Direct Current Stimulation on Anxiety, Inhibition Control and Risk taking behavior in young university students	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal do Delta do Parnaíba	Universidade Federal do Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-48gcrk8	<NULL>	University students; aged between 18 and 30 years old; from public and private institutions in the city of Parnaíba-PI; of both genders; who are currently attending university; scoring ≥ 15 points on the Hamilton Anxiety Rating Scale (HAM A); answering negatively to all questions on the non-invasive techniques screening instrument	Having a history of seizures, epilepsy, traumatic brain injury, or unexplained loss of consciousness; having a diagnosis of any neurological and/or cognitive conditions; currently being prescribed antipsychotic, hypnotic, or sedative medications; abusing/being dependent on substances, excluding tobacco and/or caffeine; having metallic implants in the body, such as pacemakers; presenting with skin diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-3sp77cq	Treatment study of Breast Cancer related Lymphedema	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7030	Efficacy of Compressive Therapy with an Internal Foam Layer in reducing the volume of Breast Cancer related Lymphedema: randomized clinical trial	<NULL>	3, randomized-controlled, n/a	3	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital do Câncer III	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3sp77cq	<NULL>	Women aged 18 years and older; diagnosed with upper limb lymphedema after 6 months of surgical treatment for breast cancer; in the volume reduction phase, with 10 to 20% excess volume; classified as stage II according to the International Society of Lymphology classification, in which there is the presence of interstitial fibrosis; with or without a lock sign and with mild to moderate volume changes	Women undergoing bilateral lymphadenectomy or with bilateral lymphedema; lymphedema since the preoperative period; presence of phlogistic signs in the edematous limb; with lesions with loss of continuity in the skin of the limb with lymphedema; previous history of allergic reaction to the material used for compression therapy; active locoregional or distant disease; undergoing chemotherapy or radiotherapy; those with functional changes in the upper limbs prior to the diagnosis of breast cancer; those with heart disease and decompensated systemic arterial hypertension; psychiatric, mental, neurological disorders or cognitive deficits that make it impossible for them to answer the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-5s234bn	Immediate and adaptive effect of interventions with and without physical exercise on the quality of walking in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2024-05-28	<NULL>	<NULL>	7032	Acute and chronic effect of motor and non-motor intervention on gait asymmetry in patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-5s234bn	<NULL>	For participants of the Parkinson group: have a minimum age of 50 and a maximum of 80 years; both genders; having a diagnosis by a private neurologist that indicates the presence of Idiopathic Parkinson Disease; have independent locomotion without the aid of auxiliary devices (cane, for example); being under drug treatment with stable levodopa for at least 3 weeks; not having undergone brain surgery or deep brain stimulation for Parkinson Disease treatment; no history of orthopedic and vision problems that make it impossible to comply with the experimental protocol (corrected vision with glasses is allowed); not having uncontrolled cardiovascular, metabolic or inflammatory problems; not showing advanced cognitive decline; present a medical certificate authorizing the performance of physical exercise. For control group participants: have a minimum age of 50 and a maximum of 80 years; both genders; independent locomotion without aid of auxiliary devices; not having history of orthopedic and vision problems that make it impossible to comply with the experimental protocol (corrected vision with glasses is allowed); not having uncontrolled cardiovascular, metabolic or inflammatory problems; not showing advanced cognitive decline	Do not present proof of Parkinson&apos;s disease, only for participants in the Parkinson&apos;s group in interventions 1 and 3; those with other neurological disorders; heart problems (i.e., arrhythmias, indication of myocardial ischemia); musculoskeletal disorders; cognitive deficits; brain surgery or Deep Brain Stimulation for the treatment of Parkinson disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-8nsbprb	Effects of Physical Training associated with Transcranial Direct Current Stimulation on the physical performance of individuals with Chronic Obstructive Pulmonary Disease - COPD	Not yet recruiting	Intervention	2024-05-29	<NULL>	<NULL>	7037	Effects of in-person and remote Physical Training and Transcranial Direct Current Stimulation on the functional, neuromuscular and mechanical performance of individuals with COPD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Instituto de Educação Superior da Paraíba - IESP	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-8nsbprb	<NULL>	Subjects diagnosed with mild or moderate Chronic Obstructive Pulmonary Disease - COPD according to the Global Initiative for Chronic Obstructive Lung Disease criteria (GOLD 1: Forced expiratory volume in the first second (FEV1) mild ≥ 80% of predicted, GOLD 2: 50% moderate ≤ FEV1 &lt;80% of predicted); of both sexes; aged between 45 and 75 years; and classified as sedentary or insufficiently active (International Physical Activity Questionnaire - IPAQ, reduced version)	Individuals with acute exacerbation of Chronic Obstructive Pulmonary Disease - COPD, with unstable hemodynamic parameters (blood pressure &lt;100mmHg systolic and &lt;60mmHg for diastolic and Mean Arterial Pressure (MAP) &lt;80mmHg), who have undergone surgery in the last 6 months; with a recent history of chest wall trauma or abdominal trauma; and/or substantial chest wall deformity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-8m9p6ht	Effect of Functional Fitness and Urban Dances on the physical and psychological health of Menopausal Women	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7041	Functional Fitness and Urban Dances in the physical and psychological aspects of Menopausal Women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-8m9p6ht	<NULL>	Only menopausal women between 40 and 59 years old who fall into the Menopause Rating Scale; who have serum follicle-stimulating hormone levels greater than or equal to 25 IU/ml; who have not practiced Functional Fitness and Urban Dances in the three months prior to data collection; who refrain from practicing these same types of physical exercise in an environment other than that of the research, during the 12 weeks, however, any other type of physical exercise or physical activity that the participant is already practicing or will carry out throughout the year may be carried out. of this period	Women who do not have menopausal symptoms according to the Menopause Rating Scale cutoff point 1 point; do not abstain from training during the intervention period (12 weeks); those with a history of neurological and musculoskeletal diseases; who have performed aerobic, resistance, or dance training in the three months prior to data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-7pbwhnv	New Moisturizing Cream containing pre- and post-biotics in the skin bacteria of patients with Atopic Dermatitis	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7042	New Moisturizing Cream containing pre- and post-biotics in the skin microbiome of patients with Atopic Dermatitis: a pilot study of therapeutic intervention, randomized, prospective, comparative, parallel-group, double-blind, placebo-controlled	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7pbwhnv	<NULL>	Signature of the Informed Consent Form (ICF) and Assent Form before any study procedures; Patients of any gender, aged one to fourteen years old; Clinical diagnosis of mild atopic dermatitis (SCORAD less or equal to 20). Eczematous lesions present in the antecubital fossae	Patients or guardians who do not agree with the study conditions or lack the capacity to understand and strictly follow the received instructions, without availability to attend reassessments, or who refuse to sign the Informed Consent Form (ICF) and Assent Form; non-agreement to sign the Photography Authorization Form will not be a reason for exclusion from the study; Pregnant or lactating women; Moderate and severe atopic dermatitis; Immunosuppression or genodermatoses, such as Netherton syndrome; Chlorine bath in the last week; Use of topical corticosteroids or calcineurin inhibitors in the last two weeks; Use of topical or oral antibiotics in the last thirty days; Use of oral immunosuppressive medications in the last thirty days; Use of immunobiologics in the last sixteen weeks; Use of phototherapy in the last thirty days; Active bacterial, viral, or fungal skin infections; Hypersensitivity to any component of the formulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-5y5pbpr	Effect of acute use of Melatonin on Hemodynamic, Metabolic and Physical Variables during and after Running exercise in different conditions	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7044	Effect of acute Melatonin administration on Physiological and Physical Performance Parameters during and after Running in different conditions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de São Carlos - UFSCar	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-5y5pbpr	<NULL>	Men and women aged between 18 and 35; apparently healthy; physically independent; normotensive; non-obese (i.e., Body Mass Index greater than 30 kilograms per square meter and body fat percentage less than 20 percent; not tobacco or alcohol users; moderately active (i.e., greater than or equal to 150 minutes per week of physical activity ); engaged in regular physical training programs.	Subjects who self-report cardiovascular, metabolic diseases, sleep and neuromuscular disorders and/or musculoskeletal injuries; continuous use of dermatological medications and antipyretics and diuretics; have used ergogenic substances (e.g., anabolic androgenic steroids) in the last six months prior to the start of research; skin folds in the regions of interest (front of the thigh and arm) greater than 20 millimeters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-78w4k8c	Omega-3 nutrient supplementation and inflammatory and metabolic markers in people with Obesity: a randomized, controlled, double-blind clinical study	Not yet recruiting	Intervention	2024-06-05	<NULL>	<NULL>	7048	Physiological dose DHA supplementation and inflammatory and metabolic markers in people with Obesity: a randomized, controlled, double-blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-25	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78w4k8c	<NULL>	Female biological sex; male biological sex; age range between 18 and 59 years; BMI equal to or greater than 30 kg /m2 (indicating obesity); sedentary (practicing less than 150 minutes of moderate to vigorous aerobic activity per week)	Unstable weight (2kg in the last 6 months); previous history or evidence of diseases that compromise the absorption of nutrients; cognitive impairment, in a way that compromises the understanding and consequent acceptance of participation in the research; hypertension; pacemaker patients; being in the gestational period or menopause; having an irregular menstrual cycle; smokers; have a food allergy or debilitating disease(s) of the gastrointestinal tract or some type of impairment of nutrient absorption; drug addicts or those with a history of misuse; those who start a diet or a sporting discipline during the study; those who are using or who during the study need to use medication that compromises or biases the results of the study; non-adherence to the proposed treatment (intervention); denial or withdrawal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-5z6dxkr	Comparison between normal diet and special diet for Diabetes in controlling blood sugar level in critically ill patients	Not yet recruiting	Intervention	2024-06-05	<NULL>	<NULL>	7050	Comparison between standard formula and specialized formula for Diabetes in glycemic control in critically ill patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-06-30	Centro Universitário do Espírito Santo - UNESC	Hospital e Maternidade São José - HMSJ	https://ensaiosclinicos.gov.br/rg/RBR-5z6dxkr	<NULL>	Adult and elderly patients - minumum age 18 years old; on invasive mechanical ventilation; of both sexes; who present hyperglycemia (blood glucose ≥180 mg/dl) in the first 72 hours after hospitalization	Patients already admitted to palliative care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-7nrvmmm	Clinical trial on the incidence of complications related to the insertion of more than one Central Venous Access into the internal jugular vein	Not yet recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7052	Incidence of complications related to multiple Central Venous Access in the internal jugular vein: multicenter randomized non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição	Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7nrvmmm	<NULL>	Patients over 18 years of age; ASA I to IV; scheduled for heart surgery; vascular surgeries; abdominal surgeries; major thoracic surgeries; liver transplants; lung transplants; with anesthetic planning for the insertion of at least two central venous catheters	Patients with a previous history of central venous thrombosis; or central venous stenosis; patients under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-2md8855	Effect of Transcranial Neuromodulation (TN) associated with a program based on meditation on the pain of women with Migraine	Not yet recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7055	Effect of Transcranial Magnetic Stimulation (TMS) associated with a program based on Mindfulness meditation on the pain of women with Migraine: a feasibility study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-20	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-2md8855	<NULL>	Women (cis or trans). Aged between 18 and 65 years old. Present a diagnosis of Migraine according to the criteria of The International Classification of Headache Disorders (ICHD-3) 2018, for more than 3 months: at least five attacks meeting criteria from B to D; headache attacks lasting 4-72 hours (without treatment or with ineffective treatment); the headache has at least two of the following characteristics: unilateral location, pulsatile character, moderate or severe pain intensity, exacerbated by or causing the individual to avoid routine physical activities (for example: walking or climbing stairs); during headache, at least one of the following: nausea and/or vomiting, and photophobia and phonophobia, not better explained by another ICHD-3 diagnosis	Participants who are at a peak of cardiovascular disease or have severe cardiopulmonary disease. With sequelae of neurological diseases. Use walking aids. With visual and hearing impairments. With amputations of lower and upper limbs. With rheumatic diseases in the acute phase. Cancer. Epilepsy. Fractures of the skull, neck or rib cage. Severe osteoporosis. People with a pacemaker or implantable cardioverter defibrillator, epilepsy or who underwent surgery less than 1 year ago. Pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-59xmv6s	Non invasive electrical stimulation of the head combined with physical exercise for individuals with shoulder pain for more than three months	Not yet recruiting	Intervention	2024-06-08	<NULL>	<NULL>	7058	Effects of Transcranial Direct Current Stimulation combined with Physical Exercise on pain and function in individuals with Chronic Shoulder Tendinopathy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-28	Faculdade de Ciências da Saúde do Trairi, Universidade Federal do Rio Grande do Norte - FACISA/UFRN	Faculdade de Ciências da Saúde do Trairi, Universidade Federal do Rio Grande do Norte - FACISA/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-59xmv6s	<NULL>	Men and women who have a clinical and/or imaging diagnosis (ultrasound or magnetic resonance imaging) of shoulder tendinopathy, accompanied by pain for more than three months during resisted abduction and external rotation movements of the shoulder and have shoulder pain; report pain ≥3 on the Numerical Pain Scale; age between 18 and 65 years old; have central pain sensitization according to the Central Sensitization Questionnaire Brazilian Portuguese Central Sensitization Inventory – BP and not present neuropathic pain; not have a neurological deficit that could compromise the follow-up and understanding of interventions; do not use implanted metallic devices, in addition to not being pregnant; not be undergoing any other medication or physiotherapeutic treatment for tendinopathy throughout the study; Individuals with initial pain intensity less than 3 (END &lt; 3) will not be included in the study, to avoid ground effect bias	Individuals with complete rotator cuff tear; report pain and/or irradiation to the spinal region; have other disorders such as frozen shoulder, severe osteoarthritis, fracture and dislocation; those who had a corticosteroid injection in the last 6 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-42xvqrz	Does Combined Non-Invasive Neuromodulation affect cerebral oxygenation and the sympathetic/parasympathetic system in subjects with Depression? Controlled and randomized study	Not yet recruiting	Intervention	2024-06-12	<NULL>	<NULL>	7063	Does Combined Non-Invasive Neuromodulation affect intracranial hemodynamics and sympathetic/parasympathetic neurovegetative tone in subjects with Depressive Disorder? Controlled and randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-42xvqrz	<NULL>	Participants with mild and moderate depressive disorder; aged between 18 and 45 years; diagnosed and reported by a professional psychiatrist and/or psychologist	Individuals with epilepsy using anticonvulsant medication and/or sleep deprivation; participants with metallic materials implanted in or near the head; participants with cardiac pacemakers or wires (Stents) or with another active device in which the interaction with the electric field may interfere with its functioning; participants with eczema on the head	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-8p38sh3	Use of Auriculotherapy for Urinary Incontinence in adults or elderly people who have undergone genital or urinary surgery	Not yet recruiting	Intervention	2024-06-12	<NULL>	<NULL>	7065	Efficacy of Auriculotherapy for Urinary Incontinence in adults or elderly people undergoing genitourinary surgical procedures: mixed methods study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-8p38sh3	<NULL>	Adults or elderly people will be included; who undergo genitourinary surgery at a university hospital in southern Brazil; who are in the immediate post-operative period (between 24 hours and seven days) or late post-operative period (from the seventh post-operative day); have moderate, severe or very severe urinary incontinence, as classified using the urinary incontinence severity assessment questionnaire – Incontinence Severity Index; and, have preserved cognitive capacity, assessed through the Mini Mental State Examination	People who underwent treatment for urinary tract infections within 30 days of data collection; patients who require the use of an indwelling bladder catheter postoperatively	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-4pkhf4b	Effect of Therapeutic Laser Compared to Standard Care on Pain and Inflammation in Postoperative Cesarean Section: Comparative Study	Not yet recruiting	Intervention	2024-06-13	<NULL>	<NULL>	7067	Efficacy of Low-Level Laser compared to usual care on pain Intensity and inflammatory modulation of immediate postoperative cesarean section wound: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-24	Departamento de Fisioterapia da Universidade Federal de Pernambuco - Campus Recife	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4pkhf4b	<NULL>	Participants who are over eighteen years old; participants without any clinical or obstetric complications and who have a score higher than three on the Visual Analog Scale VAS	Participants lacking capacity to consent; postpartum participants who have experienced complications such as hemorrhage; cesarean wound dehiscence; or sepsis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-98rr4sm	Clinical comparison between the use of a giomer technology composite resin and resin-modified glass ionomer cement in restorations in posterior primary teeth: a randomized clinical trial	Not yet recruiting	Intervention	2024-06-17	<NULL>	<NULL>	7072	Comparison of clinical success between giomer resin composite restorations and resin-modified glass-ionomer cement in primary molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-10	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-98rr4sm	<NULL>	Children aging between 4 and 8 years; both genders; children presenting good health conditions; children whose parents or legal guardians accept and sign the consent form; children with at least one occlusal proximal caries in primary molars, only occlusal-proximal surfaces with caries with dentin involvement	Severe behavioral issues; presence of fistula or abscess near the selected tooth; presence of pulp exposure in the selected tooth; presence of mobility in the selected tooth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-4m4p248	Increased strength training volume and blood flow restriction on muscle mass gains in well-trained postmenopausal women	Not yet recruiting	Intervention	2024-06-19	<NULL>	<NULL>	7076	The effect of increased strength training volume and blood flow restriction on muscle mass gains in well-trained postmenopausal women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Pró Reitoria de Pesquisa da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4m4p248	<NULL>	Healthy volunteers; postmenopausal; aged between 47 and 80 years; non-smokers or drinkers; non-vegetarians; well-trained in strength training	Volunteers with musculoskeletal, thromboembolic, and gastrointestinal diseases; a history of cardiovascular or infectious diseases; or the presence of varicose veins in the legs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-2xjfkk8	Effect of combination diuretics in patients with acutely decompensated Heart Failure and Acute Kidney Injury: a randomized controlled clinical trial	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7080	Effect of combined diuretic therapy in patients with acutely decompensated Heart Failure and Acute Kidney Injury: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2xjfkk8	<NULL>	Patients of both sexes will be included in the study; older than 18 years; with a previous clinical diagnosis of heart failure; in daily home use of oral loop diuretic (furosemide ≥ 80 mg and ≤240 mg); with clinical signs of volume overload (edema, ascites, pleural effusion or pulmonary congestion); Acute Kidney Injury KDIGO 1 and 2 admitted to the Clinical Emergency Room at the Referred Emergency Room of Hospital das Clinicas de Botucatu	Exclusion criteria will be use of vasoactive drugs, systolic blood pressure less than 90 mmHg; stage 5 chronic kidney disease or KDIGO 3 Acute Kidney Injury on admission; presence of hemodynamically significant arrhythmias; hypokalemia and hyponatremia on admission; inability to comply with planned study procedures or refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-10p7wv9y	Change in electrical properties of leg muscle by stimulation of Systemic Acupuncture points	Not yet recruiting	Intervention	2023-10-05	<NULL>	<NULL>	7081	Change Dielectric Constant by stimulation of Systemic and Auricular Acupuncture points	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10p7wv9y	<NULL>	Healthy volunteers; both genders; age between 18 and 38 years	Fear of needles; pregnant women; women with delay in menstrual cycle longer than 28 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-6xhtgj8	Effects of exergame physiotherapy on clinical-functional outcomes, hemodynamic parameters and epigenetic markers in sedentary hypertensive elderly women	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7082	Effects of kinesiotherapy intervention with exergame on clinical-functional outcomes, hemodynamic parameters and epigenetic markers in sedentary hypertensive elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Universidade de Passo Fundo	Universidade Regional Integrada do Alto Uruguai e das Missões	https://ensaiosclinicos.gov.br/rg/RBR-6xhtgj8	<NULL>	Being female. Be aged 60 or over. Have the ability to walk. Be sedentary according to the World Health Organization  WHO 2018 classification  practicing less than 150 minutes of moderate physical exercise per week. Have a previous diagnosis of hypertension, have been using antihypertensive medication for at least three months and are not in a hypertensive crisis Systolic Blood Pressure  SBP maior que 180 milímetros de mercúrio mmHg and Diastolic Blood Pressure  DBP maior que 120 milímetros de mercúrio mmHg. Present a preserved cognitive aspect, according to the results of the Montreal Cognitive Assessment - MoCA  above 26 points. Participants who do not reach the minimum score will normally participate in the study, but will not be included in the data analysis	Inability to communicate with investigators. Present a high risk of deep vein thrombosis. Grade II and III obesity Body mass index BMI≥35 kg/m2. Participants who do not achieve 75% attendance at meetings. Patients with a cardiac pacemaker. Present depressive symptoms (above 6 points) according to the results of the geriatric depression scale (GDS-15). Have a previous diagnosis of oncological, rheumatological, cardiovascular diseases (except SAH), kidney disease resulting from Systemic Arterial Hypertension - SAH or with cardiovascular, neurological, psychiatric and/or cognitive, immunological and hematological repercussions. Patient on continuous use of hypoglycemic medications. Patients with reduced mobility (range of movement)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-2258hp5	The effectiveness of topical Estradiol, Vaginal Dilators or a combination of both in preventing vaginal stenosis after Radiotherapy for the treatment of cervical cancer	Not yet recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7086	Randomized clinical trial with topical use of Estradiol, Vaginal Dilator and the combination of both in the prevention of vaginal stenosis in women with cervical cancer after treatment with Radiotherapy	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2258hp5	<NULL>	Women diagnosed with cervical cancer with disease stage I to IIIC2, who are recommended to undergo pelvic Radiotherapy treatment.	Age under 18 or over 75 years old; use of hormonal therapy in the three months prior to inclusion; previous pelvic radiotherapy treatment; refuse to participate in the study; be under treatment or have been treated for breast or endometrial cancer from the time of inclusion; suspicion of neoplasm or hormone-dependent precursor lesion during study follow-up; personal history of thromboembolism or diagnosis of thrombophilia; current or recent history (less than 6 months) of angina or stroke or myocardial infarction; active liver disease; hypersensitivity to the components of the medications used in the study or the orthosis (dilator); porphyria; neurological diseases disabling the ability to follow study instructions; use of an implanted ferromagnetic defibrillator or pacemaker and cochlear implant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-8m8754y	Comparison of the success of two antibiotic pastes used in root canal treatment without instrumentation	Not yet recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7088	Evaluation of the sucess rate of two antibiotic pastes used in lesion sterilization and tissue repair: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8m8754y	<NULL>	Children aged 3 to 11 years; no distinction between the sexes; with at least one deciduous molar diagnosed with irreversible pulpitis or pulp necrosis and internal or external resorption; sufficient tooth structure to allow absolute isolation of the operative field and rehabilitation with a stainless steel crown	Children who present any systemic alteration; history of allergic reaction to the components of the pastes to be studied; and have used antibiotics in the last three months from the date of the exam; patients with systemic manifestations (fever and extra-oral abscess) resulting from the infectious process of dental origin or teeth that present obliteration of the pulp canal; impairment of the bone crypt of the permanent tooth; coronary destruction that makes absolute isolation with a rubber dam and/or rehabilitation with a stainless steel crown impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-9zvtc5b	Assessment of functional capacity, falls, frailty and vulnerability of elderly people	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7098	Assessment of functional capacity, falls, frailty and clinical-functional vulnerability of frail and non-frail elderly people	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Ana Paula Felix Arantes	Centro de Referência em Hipertensão e Diabetes	https://ensaiosclinicos.gov.br/rg/RBR-9zvtc5b	<NULL>	Elderly people over the age of 60 years; elderly people which are not included in a regular physical exercise program	Elderly people who might have any clinical conditions that contraindicate the practice of physical activity; elderly people with cognitive deficits that might limit the performance of assessments and/or interventions (present under 19 points on the Mini Mental State Examination)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4zjkzv7	Salivary fluoride following toothbrushing in the oral cavity and prevention of dental caries with the use of brazilian red propolis toothing	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7101	Fluoride concentration in the oral cavity and prevention of dental caries using Brazilian red propolis dentifrice: randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Departamento de Farmácia - Universidade Federal do Ceará	Departamento de Farmácia - Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4zjkzv7	<NULL>	Individuals with orthodontic braces; aged between 8 - 18 years;both genders; individuals with visible plaque; individuals with at least 20 teeth; individuals with no caries lesions	Pregnant women; allergy history; systemic diseases; use of professional fluorides in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10xsbmmb	Effectiveness of Exercise and Education via Telehealth in Patients with Back Pain	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7103	Efficacy and equity of exercise combined with education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-21	Universidade Federal dos Vales de Jequitinhonha e Mucuri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10xsbmmb	<NULL>	Patients of both genres; over the age of 18; who have had non-specific low back pain for at least 3 months; disability scores of 4 out of 24 points or more on the Roland Morris Disability Questionnaire; and pain intensity scores of 3 out of 10 points or more on an 11 point Numerical Pain Scale; able to read and understand Portuguese; and with internet access	Suspected or confirmed severe spinal pathology (fracture, metastatic, inflammatory or infectious diseases of the spine, cauda equina syndrome/generalized neurological disorder); radiculopathy, grade 2 affected strength, reflex, or sensation to the same nerve root; previous history of spine surgery in the last 12 months; scheduled for major surgery during the study or follow up period; pregnancy; and contraindications to exercise listed in the American College of Sports Medicine guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4pvhhg5	The Use of Laser in Runners with Achilles Tendonitis using Vascular Points Technique: A clinical, longitudinal, Interventional Study	Not yet recruiting	Intervention	2024-06-27	<NULL>	<NULL>	7107	Photobiomodulation in Runners with Achilles Tendinopathy using the Vascular Points Technique: Clinical, longitudinal, interventional study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade São Francisco - USF	Universidade Federal de São Paulo - Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-4pvhhg5	<NULL>	Volunteers with insertional calcaneal tendon tendinopathy or in the tendon body, both genders, age between 18-55 years, runners (minimum 10-50 km per week) are in activity that present: symptoms and/or functional disability: VISA-A (&lt;80); Numerical pain scale (&gt;4) during running activity; pain at tendon palpation; modified Blazin &gt; 3; Evaluation of symptoms and functional capacity in Heel Rise and unipodal jump	Volunteer who has a history of previous lower limb surgery ; any physiotherapeutic treatment for calcaneal tendon tendinopathy in the last 6 months; individuals with a history of recent fracture and/or calcaneal tendon rupture; history of prolonged use of corticosteroids and/or anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4bxpkbb	A New Lung Treatment Device for Adult Patients with a Breathing Tube: a Randomized Controlled Clinical Trial	Not yet recruiting	Intervention	2024-06-27	<NULL>	<NULL>	7109	A new Lung Expansion Device for adult Tracheostomized patients: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Fundação Universidade Federal Do Amapá	Fundação Universidade Federal Do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4bxpkbb	<NULL>	Adult patients aged 18 and over. Hospitalized patients. Patients without impairment of cognition and understanding	Patients requiring invasive mechanical ventilation. Tracheostomy patients due to neuromuscular diseases or spinal cord injury. Patients who withdraw from participating in the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-6kzpwyk	Salivary Cortisol level to assess Anxiety of children before surgery with the use or not of medicine	Not yet recruiting	Intervention	2024-06-28	<NULL>	<NULL>	7111	Salivary Cortisol and preoperative Anxiety level of children with the use or not of pre-medication: clinical trial	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-10-01	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-6kzpwyk	<NULL>	Children aged 2 to 9 years; both genders; indication of small and medium-sized elective surgery; literate responsible	Children who receive chronic medications that depress the central nervous system, such as for the treatment of autism spectrum disorder, attention deficit hyperactivity disorder; american society of anesthesia classification greater than II; use of corticosteroids; carrying out dental treatment in the 24 hours before surgery; surgeries performed after 10 am, a time defined due to the circadian cycle, which causes a bias in the collection of salivary cortisol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-26jjmzm	Psychological intervention pProtocol for promoting Healthy Ageing	Not yet recruiting	Intervention	2024-07-04	<NULL>	<NULL>	7120	Personality change focused on Healthy Aging: proposing and evaluating the validity of a psychological intervention protocol	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Centro Universitário Estácio de Sá de Santa Catarina	Centro Universitário Estácio de Sá de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-26jjmzm	<NULL>	minimum level of secondary education completed; interest and willingness to participate in the research for a period of one year; ability to answer psychological instruments	be under the age of 18; undergoing psychotherapy; undergoing psychiatric treatment or taking psychiatric medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-96x28w8	The tactical performance of football players under Cerebral Stimulation	Not yet recruiting	Intervention	2024-07-08	<NULL>	<NULL>	7123	Ergogenic effect of Transcranial Continuous Current Stimulation on the tactical performance of football players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-96x28w8	<NULL>	Participants over 18 years old up to 40 years old; fit to play football; Participants without injuries	Participants with injury; injured participants; participants returning from injury; participants who consume psychoactive and psychodepressant medications; participants who have a history of depression and epilepsy; participants who are absent twice consecutively; participants with any cardiovascular, osteo-articular and central problem for physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-2zx5y9r	Use of the Placental Growth Factor (PlGF) test in pregnant women with Chronic Hypertension to evaluate superimposed Pre-eclampsia	Not yet recruiting	Intervention	2024-07-09	<NULL>	<NULL>	7127	Implementation of the PlGF test to evaluate superimposed Pre-eclampsia in pregnant women with Chronic Arterial Hypertension: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2zx5y9r	<NULL>	All pregnant women diagnosed with chronic hypertension and clinical suspicion of superimposed preeclampsia (due to worsening blood pressure control); age over 18 years; gestacional age over 20 weeks; exacerbated weight gain; emergence or worsening of proteinuria; signs of placental insufficiency after 20 weeks of gestation	HELLP syndrome; eclampsia; signs of imminent eclampsia; hypertensive crisis, when systolic blood pressure ≥160 and/or diastolic blood pressure ≥110mmHg; acute fetal distress	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-9857xj3	Impact of physical exercise on heart and skeletal muscle health	Not yet recruiting	Intervention	2024-07-12	<NULL>	<NULL>	7131	Evaluation of the effect of a physical exercise program on the muscular and vascular health of elderly individuals	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-08-15	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-9857xj3	<NULL>	Elderly people (over 60 years of age); male and female sex; high triglycerides (&gt;150 mg/dL); reduced HDL-cholesterol (&lt;50 mg/dL for men and &lt;40 mg/dL for women); waist circumference &gt; 102 cm for men and &gt; 88 cm for women; hypertensive (systolic pressure above 130 mm Hg and diastolic pressure above 90 mm Hg); and increased fasting blood glucose (&gt; 100 mg/dL) or diagnosed with type II diabetes mellitus; with or without a diagnosis of common mental disorder (anxiety and/or depression). Young people (over 18 years old); male and female sex; sedentary or physically active; no musculoskeletal diseases; with or without the presence of risk factors for cardiovascular diseases; with or without a diagnosis of common mental disorder (anxiety and/or depression)	Osteoarthritis and rheumatoid arthritis; infected with HIV virus; use of drugs that interfere with the vascular and nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-8kdv3pt	Effects of Light Therapy and Manual Manipulation Technique on improving physical capacity and reducing pain in adults subjected to Muscle Damage	Not yet recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7132	Effects of Photobiomodulation and Osteopathy on blood and salivary parameters, pain perception and physical performance in young adults undergoing Muscle Damage induced by physical exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal de Jataí	Universidade Federal de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-8kdv3pt	<NULL>	The study will include male people; aged between 18 and 35 years; Caucasian and unused to performing plyometric jumps in their usual training; Participants must also have at least 6 months of experience with resistance training	Individuals who use nutritional supplements or anti-inflammatory and pain medications in the last seven days will be excluded; having consumed alcohol or ergogenic drinks 72 hours before the tests; present musculoskeletal injury; not carrying out all the collection stages and/or giving up during the study; practitioners of sports that involve plyometric jumps	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-557c2cz	Use of Myoinositol in patients with Polycystic Ovary Syndrome who will undergo a procedure to try to get pregnant	Not yet recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7133	Myoinositol as adjuvant therapy in patients with Polycystic Ovary Syndrome undergoing Assisted Reproduction procedures	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-557c2cz	<NULL>	Women; between 18 and 40 years of age; with a body mass index between 18 and 34,9 kg/m2; diagnosed with Polycystic Ovary Syndrome according to the Rotterdam criteria; diagnosed with marital infertility according to the World Health Organization criteria; who agree to sign the Term of Free and Informed Consent	Presence of other diseases that cause hyperandrogenism (non classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid diseases without adequate control, androgen secreting tumors, Cushing&apos;s Syndrome); Type 1 diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-7w75qby	Pharmacological Therapy for the treatment of Obstructive Sleep Apnea: a randomized clinical trial	Not yet recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7134	Reboxetine and Oxybutynin for the treatment of Obstructive Sleep Apnea: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-09-01	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7w75qby	<NULL>	Patients aged 18 years or older diagnosed; both genders; with Obstructive Sleep Apnea according to the criteria of the American Academy of Sleep Medicine (AASM).	Pregnant patients; cognitive disorders that prevent understanding to provide consent and adequate use of proposed therapies; use of medications or drugs that have a known interaction with the proposed therapy; allergy to any of the components of the proposed therapies; angle-closure glaucoma; partial or total obstruction of the gastrointestinal tract; paralytic ileus; intestinal atony in the elderly; megacolon; toxic megacolon; complication of ulcerative colitis;  severe colitis; myasthenia gravis; unstable cardiovascular status due to acute hemorrhage; obstructive uropathy or urinary retention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-68j3f26	Treating Endometriosis: Pill of Dienogest alone vs. Pill of Dienogest with Hormonal Intrauterine Device - a randomized clinical trial	Not yet recruiting	Intervention	2024-07-16	<NULL>	<NULL>	7139	Endometriosis treatment with Dienogest Monotherapy or Dienogest associated to Intrauterine Dispositive of Levonorgestrel - a randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Estadual de Campinas	Hospital da Mulher José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-68j3f26	<NULL>	Women aged 18 to 45 years. Diagnosis of endometriosis by specific imaging examination ultrasound, magnetic resonance imaging (MRI). Present at study entry with complaints of pelvic pain and/or deep dyspareunia. Agree to the use of dienogest or levonorgestrel intrauterine device (LNG IUD). No contraindications to the use of levonorgestrel intrauterine device (LNG IUD). No desire for pregnancy during the one-year study period	Asymptomatic women. Women who have not initiated sexual activity. Women with psychiatric or neurological disorders that compromise the ability to respond to the questionnaires developed such as schizophrenia, neurodegenerative disorders, severe depression. Women undergoing treatment for chronic systemic diseases that lead to painful symptoms fibromyalgia, interstitial cystitis, neuropathic pain. History of abdominal surgery hysterectomy, colectomy, exploratory laparotomy, complicated appendectomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9mtwh2j	Effectiveness of technologies in maintaining venous access in hospitalized children and adolescents	Not yet recruiting	Intervention	2024-07-19	<NULL>	<NULL>	7143	Effectiveness of technologies in the Maintenance of short Peripheral Intravenous Catheters in hospitalized children and adolescents (ManCIP)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-22	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-9mtwh2j	<NULL>	Age between 1 and 14 years old. Intravenous therapy peripherally for 48 hours or more. Use of a Short Peripheral Intravenous Catheter for intermittent or continuous medication administration	Children who request to withdraw their consent or whose parents no longer consent to their participation during follow-up and children who remove the Short Peripheral Intravenous Catheter accidentally or on their own will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6ktzzh8	Affective experience and opioid use before anesthesia: a double-blind randomized clinical trial	Not yet recruiting	Intervention	2024-07-22	<NULL>	<NULL>	7147	The affective experience and use of opioids before anesthetic induction: a double blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-08-10	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Faculade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6ktzzh8	<NULL>	Both genders; age range between 18 and 65 years old; classified according to surgical risk as ASA 1 or ASA 2 or ASA 3; according to medical assessment based on health history, physical examination and laboratory tests; subjected to previously scheduled surgery, and may or may not be hospitalized with general anesthesia	"Physical or intellectual inability to respond to the questionnaires, as assessed by the researchers;
Illiterate; patients who have a previous history of an allergic reaction to opioids; chronic opioid users;
users of psychoactive drugs for recreational use; patients with nephropathy, pacemakers and beta blockers"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-52r82gy	Comparative study of donated corneas with and without Descemet&apos;s membrane in corneal transplants with perforation during surgery	Not yet recruiting	Intervention	2024-07-23	<NULL>	<NULL>	7148	Comparison of donated corneas with and without Descemet&apos;s membrane in deep anterior lamellar corneal transplantation with intraoperative perforation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-15	Hospital Oftalmológico de Sorocaba	Hospital Oftalmológico de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-52r82gy	<NULL>	Patients 18 years of age or older; patients indicated for  deep anterior lamellar keratoplasty (DALK) by the Hospital Oftalmológico de Sorocaba (HOS); patients who agree to participate in the study	Patients who do not present intraoperative perforation of the Descemet&apos;s membrane; patients requiring conversion to penetrating keratoplasty (PK); pregnant or breastfeeding woman; patients who at some point give up participating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-2f58ykv	Educational-care strategy for guidance on self-care, through a chatbot, for the Health Care Network and for people with intestinal stoma	Not yet recruiting	Intervention	2024-07-29	<NULL>	<NULL>	7162	Educational-care technological strategy for guidance on self-care, through a chatbot-type mobile application, to Health Care Network and for people with intestinal ostomies in State of Pernambuco	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-20	Fundação Universidade de Pernambuco	Complexo Hospitalar do Hospital Universitário Oswaldo Cruz/Pronto-Socorro Cardiológico Universitário de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2f58ykv	<NULL>	Age equal to or over 18 years old; have a colostomy or ileostomy; post-operative time from 1 to 4 months	Illiterate; psychiatric disorder; cognitive deficit; physical disability that compromises the practice of self-care; total or partial sensorimotor alteration; presence of peristomal dermatitis; presence of prolapse; presence of a hernia; presence of retraction; have received prior guidance on how to care for an intestinal ostomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-5r6pm9x	Effects of Neuromodulation associated with Treadmill gait Training on functional mobility and balance in people with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-08-01	<NULL>	<NULL>	7171	Effects of repetitive Trans-spinal Magnetic Stimulation associated with Treadmill gait Training on functional mobility and postural balance in people with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5r6pm9x	<NULL>	Men and women between 18 and 80 years old; people with Parkinson&apos;s Disease (PD) in Hoehn Yahr stages between 2 and 4 (moderate disease) whose primary symptom includes gait alteration; being able to walk independently for 30 meters or with a unilateral assistive device; having a Mini-Mental State Examination (MMSE) score greater than or equal to 24 for people with more than 8 years of schooling and above 20 points for illiterate people	Unstabilized psychiatric comorbidities; other neurological disorders, musculoskeletal, orthopedic, cardiovascular, and respiratory changes that may affect the ability to walk on the treadmill; labyrinthine problems; deep brain stimulation surgery or epidural stimulation of the spinal cord; uncontrolled infection or other uncontrolled pre-existing medical conditions (e.g. uncontrolled infection or other uncontrolled pre-existing medical conditions (e.g. decompensated diabetes, hypertension, symptomatic lung or heart disease); concomitant treatment with other experimental drugs; pregnant or breastfeeding women; chronic low back and lower limb pain; not walking without an aid (cane, crutch, walker) or help from another person; metal implants and cardiac pacemakers; history of neurosurgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-7xz8bvw	Comparison of the effect of Laser protocol and Cryotherapy on the occurrence of postoperative pain in inflamed molar teeth	Not yet recruiting	Intervention	2024-08-05	<NULL>	<NULL>	7176	Comparison of the effect of Photobiomodulation protocol and Cryotherapy on the occurrence of postoperative pain and on the success of endodontic treatment in molar teeth with Irreversible pulpitis. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-07	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-7xz8bvw	<NULL>	Capable adult patients; aged between 18 and 65 years; both genders; who already have an indication for endodontic treatment in permanent molar teeth; diagnosed with irreversible pulpitis, confirmed by a positive response to clinical, electrical sensitivity and radiographic tests; have a contact number (telephone or cell phone or username on social networks) to be able to carry out postoperative evaluations	Patients who are at any stage of pregnancy. Patients who have been taking any medication such as analgesics or anti-inflammatories in the last 48 hours or who are immunocompromised, as these factors may alter the perception of pain or interfere with the analysis of the post-treatment pain score. Patients who have teeth with endodontic complications, such as: calcifications, external or internal resorption, partial formation of the apex, with dental perforations, with longitudinal or vertical fractures or with severe periodontal disease. During the endodontic procedure, patients who cannot have the endodontic treatment completed in the same session, or those patients who for any reason cannot be contacted to perform the outcome assessment will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-84pqzdw	Stimulating movement and Physiotherapy interventions to prevent post-cesarean pain	Not yet recruiting	Intervention	2024-08-06	<NULL>	<NULL>	7177	Stimulation of movement and Physiotherapeutic interventions in the immediate postpartum of cesarean section to prevent pain due to antalgic postures: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Hospital das Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-84pqzdw	<NULL>	Postpartum women undergoing cesarean section; over 15 years old; hemodynamically stable; conscious; oriented; in good clinical condition according to progress in the medical record; whose procedure was carried out more than eight hours ago; after having had the bladder catheter removed and who ate after surgery	Women who present complications/intercurrences; who have clinical contraindications or medical diagnosis of impaired cognition that makes participation impossible; as well as those who required the use of opioid medications before allocation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-66hpcw7	Can whole genome sequencing improve Tuberculosis care?	Not yet recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7188	Evaluation of the implementation of whole genome sequencing for diagnosis, detection of resistance and choice of therapeutic regimen for Tuberculosis in clinical practice conditions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Instituto de Ciências Biomédicas da Universidade de São Paulo - ICB/USP	Instituto de Ciências Biomédicas da Universidade de São Paulo - ICB/USP	https://ensaiosclinicos.gov.br/rg/RBR-66hpcw7	<NULL>	Both sexes. Be a patient of at least one of the six medical centers participating in this study during the data collection period. Patients with treatment failure or relapse in whom antimicrobial resistance is suspected, but diagnostic resistance tests have not been performed or who have a negative result for rifampicin resistance on the Xpert® MTB/RIF Ultra. Patients with a positive test for rifampicin resistance by Xpert® MTB/RIF Ultra. Patients with a negative test for resistance to rifampicin by the Xpert® MTB/RIF Ultra, but positive for resistance to any of the first-line drugs by the Hain ribbon genotypic tests (GenoType MTBDR). Patients with relapse and previous diagnosis of resistant Tuberculosis	Extrapulmonary tuberculosis at the time of diagnosis or diagnosed during the study. Negative culture. Co-infection with nontuberculous mycobacteria. Patients who change treatment centers during the study. Patients who wish to abandon the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-45hz53y	The acidity of in-office bleaching gels affects dental sensitivity and bleaching efficacy in patients undergoing orthodontic treatment: A randomized clinical trial	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7193	Effect of the acidity of in-office bleaching gels on dental sensitivity and bleaching effectiveness in orthodontic patients: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Andres Felipe felipe Millan Cardenas	Centro Universitário de Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-45hz53y	<NULL>	volunteers over 18 years old; with devices metal and ceramic orthodontics; good general and oral health; caries-free teeth; without gingival recessions and periodontal disease in the anterior region; who agree with the term of free and informed consent (TCLE); has one of the canines with color A2 or darker according to the Vita Classical scale	Patients who report previous tooth sensitivity; who had already undergone bleaching previously; smokers; women who are pregnant or breastfeeding; who were making continuous use of medication such as analgesics or anti-inflammatories; patients who used prostheses or had restorations in the upper anterior teeth; with parafunction, gingival recession; endodontic treatment of anterior teeth; severe tooth discoloration (tetracycline staining or fluorosis) and visible cracks in teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-83fs5dr	Comparison of Treatment Duration (12 or 24 hours) for Patients with Postpartum Pre-Eclampsia: a Randomized Clinical Study	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7196	Comparison of Magnesium Sulfate regimen for 12 or 24 hours in Postpartum Women with Pre-Eclampsia: A Randomized Clinical Study	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83fs5dr	<NULL>	Pregnant patients, diagnosed with pre-eclampsia, with indication for the use of magnesium sulfate due to maternal cause, as assessed by the care team; start using magnesium sulfate before delivery, with a schedule for maintaining the medication after delivery	"Patient unable to understand the informed consent form, due to cognitive incapacity, definitive or temporary, as a result of pre-eclampsia itself (suspected bleeding in the central nervous system) or due to a cause prior to pregnancy. Patients unable to read the informed consent form (because they are intubated or have clinical or imaging evidence of neurological involvement) will not be invited to participate in this study, as they are considered to be in a vulnerable situation that prevents their participation in this protocol; gestational age is less than 24 weeks;
diagnosis of fetal death before delivery (i.e., ultrasound diagnosis of absence of fetal heartbeat upon admission for delivery); presence of multiple pregnancy (more than one fetus); patient with antenatal diagnosis of fetal malformation incompatible with extrauterine life; indication for the use of magnesium sulfate was made exclusively for fetal neuroprotection due to the risk of premature birth, without any maternal clinical indication that would justify its use; magnesium sulfate treatment was suspended before delivery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3fmc62z	Analysis of the incidence, severity and temporal evolution of motion sickness after using the Air Force Academy&apos;s T-2000, T-3000 and T-4000 flight simulators	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7199	Analysis of the incidence, severity and temporal evolution of Simulator Sickness after exposure to the Air Force Academy T-2000, T-3000 and T-4000 flight trainers: An exploratory experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade da Força Aérea	Academia da Força Aérea	https://ensaiosclinicos.gov.br/rg/RBR-3fmc62z	<NULL>	Healthy volunteers; both genders; aviation cadets enrolled in the second or fourth year of the Air Force Academy&apos;s Aviation Officer Training Course. For the sample referring to second year cadets, it will be required to have successfully completed the Primary Flight Course on the Universal aircraft. For the sample referring to fourth year cadets, it will be required to have successfully completed the Basic Flight Course on the Tucano aircraft.	Be medically exempt from aerial activity or simulator training for any reason.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-9wkqh8x	Results of Preventive Physiotherapy carried out using a cell phone application on workers&apos; Self-Perception of Health: a randomized clinical trial	Not yet recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7203	Effects of Preventive Physiotherapy mediated by Mobile Application on workers&apos; self-perceived health: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-9wkqh8x	<NULL>	Participant of both sexes; participating employee must be over 20 years old; spend more than/equal to 8 hours sitting per day; the participant must have a cell phone with the messaging application (WhatsApp) installed	Participants who are being treated for chronic illnesses; participants who are away from their work duties during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3t8pw38	Effect of Laser on maternal complications during the Postpartum period	Not yet recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7204	Effect of Photobiomodulation therapy on complications maternal during the Postpartum	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal de Alfenas- Campus Santa Clara	Universidade Federal de Alfenas- Campus Santa Clara	https://ensaiosclinicos.gov.br/rg/RBR-3t8pw38	<NULL>	Age over 18 years; primiparous or multiparous; women after vaginal delivery with grade two, three, or four perineal laceration; women after vaginal delivery with episiotomy; approximation of the edges of the lesion by means of suturing (healing by first intention); pain graded in at least two, by the numerical scale of pain; ability to understand	Refusal to receive the protocol; presence of systemic or lesion-site infectious process; Birth of twins; hemodynamic instability; postpartum complications (hemorrhages); Use of medicines for associated diseases; Smoker; Diabetes mellitus or diabetes Gestational; neurological diseases; cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-9pb4qsq	Impact of COVID-19 on tuberculosis prevention and control in Brazil: a look at social policies, the disease situation and new technologies (CoV-TB Project)	Not yet recruiting	Intervention	2024-08-12	<NULL>	<NULL>	7205	Impact of COVID-19 on the prevention and control of Tuberculosis in Brazil: Analysis of social protection policies, the epidemiological situation and technological incorporation (CoV-TB Project)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-15	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9pb4qsq	<NULL>	New cases of tuberculosis. Over 18 years old. No gender criteria. Own a mobile phone (intervention group). Health professionals responsible for Directly Observed Treatment (DOT) and/or monitoring of people with tuberculosis. Unit managers (Primary Health Care (PHC) coordinators and/or tuberculosis program coordinators of the health units in the municipalities, previously selected)	Resistant Tuberculosis. Professionals and/or managers who have been in the position or working with tuberculosis for less than 6 months. Unavailability of individual or family cell phone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-49dt8yj	Use of technologies to monitor and guarantee the treatment of Tuberculosis among Migrants, Refugees and Stateless Persons in Brazil (MIRA-TB Project)	Not yet recruiting	Intervention	2024-08-13	<NULL>	<NULL>	7216	Implementation of technologies for tracking and adherence to treatment of Tuberculosis infection or disease among International Migrants, Refugees and Stateless Persons in Brazil (MIRA-TB Project)	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-08-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-49dt8yj	<NULL>	Individuals over 18 years old; both gender; international migrants, refugees, and stateless persons diagnosed through the verification of induration (greater than 5 mm) 72 hours after the application of the Tuberculin Test (TT), applied intradermally on the forearm and/or use of the Interferon-Gamma Release Assay (IGRA) in situations where the use of TT is not possible, and according to the protocols of the World Health Organization (WHO); migrants, refugees, and stateless persons with drug-resistant tuberculosis (DR-TB) identified through project screening and/or spontaneous demand at health services, diagnosed according to the protocols of the Ministry of Health (MoH), based on the Rapid Molecular Test (RMT), sputum smear microscopy, or sputum cultur	Lack of familiarity or difficulty using a smartphone; individuals under 18 years old; Brazilians; migrants, refugees, and stateless persons not residing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-686kqdx	Chronic Effect of Time Under Stress in Recreational Runners	Not yet recruiting	Intervention	2024-08-14	<NULL>	<NULL>	7219	Chronic Effect of Strength Training with Time Under Tension on the Performance of Recreational Runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-11	Universidade Federal de Sergipe - UFS	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-686kqdx	<NULL>	Volunteer for research; be 18 years of age or older; run at least three times a week with an average weekly mileage of 16 kilometers; have an average running pace of between 5 and 5:30 minutes per kilometer over a long distance; participate in a strength training program at least once a week with at least three months of practice, report no osteoarticular injuries during the last three months that compromised strength exercises and running; and have at least one year&apos;s experience in long-distance running	Individuals who do not perform all steps as instructed; present depravity in the upper respiratory tract; injuries that make it impossible to perform maximum effort during the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-46gs8pk	How the COVID-19 Pandemic Impacted Tuberculosis Control in São Paulo Challenges Realities and Solutions Technologies	Not yet recruiting	Intervention	2024-08-15	<NULL>	<NULL>	7220	Interaction and effect of the COVID-19 pandemic on tuberculosis control in the state of São Paulo: political-social, clinical-epidemiological aspects and innovative practices	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-08-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-46gs8pk	<NULL>	Managers from different levels (federal, state, regional, and municipal) will be included. Health and social assistance professionals who have worked in healthcare and/or health surveillance for at least six months, starting from September 2019, due to their prior experience before the pandemic context. Representatives of social movements and health councils (national, state, municipal, and local) who have at least six months of experience will also be interviewed. All cases and deaths from tuberculosis (TB) reported in the Notifiable Diseases Information System (SINAN) from 2015 to 2022 and cases and deaths from COVID-19 from 2020 to 2022 available on the Coronavirus Panel will be considered. The population for this study phase will consist of people undergoing treatment for TB. No gender criteria apply. Professionals who are part of the health team responsible for Directly Observed Treatment (DOT). Managers of the units (Primary Health Care (PHC) coordinators and/or coordinators of PHC units in the municipalities and units previously selected)	Serão excluídos gestores ou profissionais que não respondam a três contatos seguidos. Só serão considerados os casos e óbitos notificados como causa básica tuberculose ou COVID-19 dentro do período citado; outras doenças ou notificações fora do período serão excluídas. Serão excluídas pessoas que não estejam fazendo tratamento para tuberculose (TB) no momento e profissionais de saúde que não atuem no Tratamento Diretamente Observado (TDO), exceto gestores das unidades	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-5zfkxdy	Evaluation study of a rapid test and treatments for Chagas disease in Bahia, Brazil	Not yet recruiting	Observational	2024-08-15	<NULL>	<NULL>	7223	Evaluation of the effectiveness of a rapid test and treatments for Chagas disease: Oxente Chagas Bahia Cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-28	Centro de Pesquisas Gonçalo Moniz	Instituto Gonçalo Moniz	https://ensaiosclinicos.gov.br/rg/RBR-5zfkxdy	<NULL>	Part A: Volunteers residing in the municipalities of Tremedal and Novo Horizonte, Bahia, with active registration in municipal health systems; both genders; and aged over nine months. Part B: Volunteers who tested positive with the Bio-Manguinhos Rapid Chagas Test, along with 10% of those who tested negative; both genders; and aged over nine months. Part C: Volunteers with laboratory-confirmed Chagas disease; both genders; aged under fifty years; and with a normal electrocardiogram (heart rate: 50-100 beats per minute, waves P and R (PR) interval ≤ 200 milliseconds, waves Q, R, and S (QRS) complex ≤ 120 milliseconds, and waves Q and T (QT) interval between 350-450 milliseconds)	Parts A and B: Volunteers residing in Novo Horizonte or Tremedal, Bahia, who are not registered with the local health systems will be excluded from the study, as will volunteers unable to undergo peripheral blood collection. Part C: Exclusion criteria include volunteers with signs of advanced chronic Chagas disease; diagnosis of HIV/AIDS, mental illness, or suicidal tendencies; any acute or chronic disease deemed contraindicated for treatment by the attending physician; history of alcoholism or drug use; known hypersensitivity to nitroimidazoles; and unavailability to comply with the procedures and visits outlined in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-105rqvph	Study to assess the quality of restorations made with composite resin and a polyethylene strip in posterior baby teeth: research with controlled trials	Not yet recruiting	Intervention	2024-08-15	<NULL>	<NULL>	7226	Clinical evaluation of the quality of direct class II restorations with composite resin associated with ribbond in primary molars: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-105rqvph	<NULL>	Children aged five to ten years old will be included; of both sexes; who may or may not have experience in dental care; and who need occlusoproximal restorative dental treatment in upper or lower deciduous molars due to caries lesions	Patients with acute pain or presence of odontogenic infection associated with systemic signs and symptoms; dental urgency; endodontic compromise; history of allergy to drugs used in the research or components of absolute isolation; history of asthma; extensive root resorption and neurological disorders will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-4nm87k2	Clinical Simulation for training health professionals in assistance in the first hour of labor and birth	Not yet recruiting	Intervention	2024-02-21	<NULL>	<NULL>	7227	Effectiveness of Clinical Simulation for training health professionals in assistance in the first hour of labor and birth: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Faculdade de Enfermagem da Universidade Federal de Goiás	Secretaria da Saúde do Estado de Goiás - Leide das Neves Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-4nm87k2	<NULL>	Health professionals in the obstetric area working in direct assistance to parturient and postpartum women and newborns in the following sectors: Obstetric Emergency, Surgical Center, Normal Delivery Unit and Joint Accommodations; be contactable by telephone; have access to the internet at home or on your cell phone; both genders	Health professionals who, during the period of data collection, are on vacation, or on sick leave, or away from care or serving prior notice; professionals who, after three attempts, are not on their original shift according to the duty schedule; professionals who have already participated in a Clinical Simulation course for Postpartum Hemorrhage (PPH)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-6t3w7pt	Evaluation of a universal adhesive containing quercetin in non-carious cervical lesion restorations: a clinical trial.	Not yet recruiting	Intervention	2024-08-16	<NULL>	<NULL>	7228	Evaluation of the clinical longevity of a universal adhesive system containing nanoencapsulated quercetin in self-etch mode in non-carious cervical lesion restorations: a double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6t3w7pt	<NULL>	Participants with good general health; participants aged over 18 years to 60 years (men and women); acceptable level of oral hygiene; participants must present at least 20 teeth in occlusion; 20 teeth in function; no active clasps from removable partial dentures on the included teeth; the teeth should not be abutments for prostheses; absence of periodontal disease; no active carious lesions; no parafunctional habits; participants should have at least two non-carious cervical lesions (NCCLs) to be restored in different teeth; the lesions should be non-retentive; lesions deeper than 1 mm; lesions that involve both enamel and dentin of vital teeth; and the cavosurface margin should not involve more than 50% of the enamel	Participants with extremely poor oral hygiene; participants using orthodontic devices; participants with severe or chronic periodontitis; participants with parafunctional habits; participants with known allergies to resin-based materials or any other materials used in this study; pregnant women; breastfeeding women; participants on chronic use of anti-inflammatories, analgesics, and psychotropics; participants who have difficulty attending follow-up appointments after the restoration will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-99qvrnj	Assessment of postoperative events after Ozonetherapy in lower third molar Extractions	Not yet recruiting	Intervention	2024-08-19	<NULL>	<NULL>	7231	Effects of Ozonetherapy in the postoperative period of lower third molar Extraction – pilot, randomized, blind, split-mouth clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-20	Instituto de Ciência e Tecnologia - Campus de São José dos Campos – Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Campus de São José dos Campos – Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-99qvrnj	<NULL>	Female and male patients,  need of third molar extraction; regardless of gender; patients who have not used analgesics or anti-inflammatories in the last 15 days; have teeth in opposing semi-included or included hemi-arches, meeting the same classification as Pell &amp; Gregory (1933); aged between 18 and 30 years; who agree to participate in the research voluntarily, being aware of the risks and benefits, and sign the Free and Informed Consent Form (TCLE).	Patients who present local or systemic changes that contraindicate the procedure; patients undergoing drug treatments that interfere with the methodology; erupted lower third molars; patients allergic to anesthetics and medications; patients with contraindications to the use of ozone therapy; smoking patients; pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-106hchyb	Immediate effects of Mechanical Knee Traction with different weights on measures of Pain and Functional Capacity in people with Knee Osteoarthritis: a randomized clinical study	Not yet recruiting	Intervention	2024-08-19	<NULL>	<NULL>	7232	Immediate effects of Mechanical Femorotibial Traction with different loads on Pain and Functional Mobility measures in people with Knee Osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-30	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-106hchyb	<NULL>	Volunteers diagnosed with knee osteoarthritis; both genders; age over 40 years; feel pain in the knee with osteoarthritis; be able to walk without the aid of canes or walkers; be able to bend the knee up to 60º	Volunteers who underwent analgesic procedures 24 hours before the research; having undergone knee surgery in the last 12 months; present systemic inflammatory disease; to have a tumor in the knee; express skin diseases and/or open wounds around the knee joint; to have pain in the lower extremities related to: central nervous system disease; fibromyalgia; polyneuropathy; restless legs syndrome; hip diseases; compression of nerve roots	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-7tpy7rr	Oropharyngeal exercises for Snoring and Sleep Apnea	Not yet recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7236	Myofunctional Orofacial Therapy for the treatment of Primary Snoring and Obstructive Sleep Apnea: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-22	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7tpy7rr	<NULL>	Patients aged 18 year or older; diagnosis of obstructive sleep apnea or primary snoring by polysomnography.	Pregnancy; age below 18 years; psychiatric and cognitive disorders that impair understanding of the proposed therapy and providing consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-5vcmzfs	Application for the detection of the risk of increased blood pressure at the beginning of pregnancy	Not yet recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7249	Assistance Application for Prediction of Preeclampsia in the First Trimester Gestational Quarter: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5vcmzfs	<NULL>	Pregnant women over 18 or under 18 who are accompanied by a legal guardian; Unique pregnancy; Pregnancy between 11+0 and 13+6 weeks of evolution	prior kidney disease; Committed physical or mental health that makes interaction with researchers unfeasible at any time of study data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-5ty2pnv	COVID-19 Pandemic and Tuberculosis Control in the State of São Paulo: Monitoring by Telemonitoring	Not yet recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7256	Impact of COVID-19 on tuberculosis control in the state of São Paulo - Brazil: Analysis of morbidity and mortality indicators and coping strategies through digital health.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5ty2pnv	<NULL>	New cases of tuberculosis. Over 18 years old. No gender criteria. Own a smartphone (intervention group). Health professionals responsible for Directly Observed Treatment (DOT) and/or monitoring of people with tuberculosis. Unit managers (Primary Health Care (PHC) coordinators and/or tuberculosis program coordinators of the health units in the municipalities, previously selected)	Resistant Tuberculosis. Professionals and/or managers who have been in the position or working with tuberculosis for less than 6 months. Unavailability of individual or family cell phone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7r6z2nk	Effects of physical exercise on the health of the heart, blood vessels and muscles in older adults	Not yet recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7258	Effects of exercise training on cardiovascular, functional, metabolic, inflammatory parameters, and body composition of older adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-7r6z2nk	<NULL>	Individuals aged 60 years or older gender both sexes; not participating in any supervised physical training program in the last 6 months; availability to perform physical exercises twice a week; not having undergone recent surgery; not having chronic obstructive pulmonary disease; feeling pain; nor having an orthopedic injury that prevents participation in the experiment; for example, joint instability; dislocation; recent fractures; severe contracture in muscles of the lower limbs	Present nausea; dizziness; discomfort; fainting; or excessive sweating; miss one of the assessments; request to leave the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-424gzzy	Evaluation of the Chemical and Mechanical Properties of Invisible Orthodontic Aligners: A Laboratory and Human Study	Not yet recruiting	Observational	2024-08-22	<NULL>	<NULL>	7259	Evaluation of the chemical and mechanical properties of orthodontic aligners: in vitro and in vivo study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-16	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-424gzzy	<NULL>	Individuals between the ages of 18 and 30; both genders; systemically healthy; with good oral hygiene; with the presence of dental malocclusion; healthy periodontium and absence of dental caries	Individuals under 18 years of age, with serious systemic alterations; using medications that may cause alterations in salivary flow; using antibiotics and anti-inflammatory drugs in the last 03 months; abnormal/non-healthy periodontium and presence of dental caries; individuals with clinical signs of parafunctional habits, free of malocclusion, and who underwent restorations in the last 12 months will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-44k3f3x	Assessment of bleaching efficacy using two concentrations of carbamide peroxide in home bleaching in adolescents	Not yet recruiting	Intervention	2024-08-23	<NULL>	<NULL>	7261	Assessment of bleaching efficacy using two concentrations of carbamide peroxide in home bleaching in adolescents: double-blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-44k3f3x	<NULL>	Good general and oral health; 12 to 16 years old; Six upper anterior teeth free of active caries and endodontic treatment; restorations of a maximum of 1/3 of the dental structure; canines (13,23) should be A2 color or darker.	Participants undergoing orthodontic treatment; dental prostheses; severe tooth discoloration (tetracycline stains, fluorosis or devitalized teeth); pregnant and lactating patients, continuous users of anti-inflammatories or analgesics; participants who have already undergone teeth whitening procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-4zvg678	Effect of Propolis Extract Supplementation and Combined Training on Chronic Low-Grade Inflammation and Oxidative Stress in Postmenopausal Overweight and Obese Women	Not yet recruiting	Intervention	2024-08-23	<NULL>	<NULL>	7262	Propolis and Exercise Training combined on Chronic Low-grade Inflammation and Oxidative stress in Overweight and Obese Postmenopausal Eomen	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-20	Pró Reitoria de Pesquisa da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4zvg678	<NULL>	Women aged between 60-79 years;  BMI between 25 and 30 kg/m2; not practicing resistance training (&gt; 6 months without practice); without weight change in 6 months; non-smoker for more than 1 year; without history of cancer, cardiorespiratory disease, uncontrolled hypertension (SBP ≥160 mmHg and DBP ≥120 mmHg)	Have any gastrointestinal discomfort or hypersensitivity to the use of propolis supplementation; have any musculoskeletal discomfort with combined training;not perform the proposed tests before and after the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-5g64wy4	Comparison of the use of Tens associated with Pilates in Chronic Low Back Pain	Not yet recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7266	Comparative analysis of association of Tens with the Pilates Method in Chronic Low Back Pain: randomized, sham-controlled and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Centro de ciências da saúde da Universidade Federal da Paraíba	Centro de ciências da saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5g64wy4	<NULL>	Volunteers aged between 18 and 85 years old; of both sexes; with a primary diagnosis compatible with nonspecific low back pain (low back pain without other specification); with a pain intensity score of 3 or higher on the Numerical Rating Scale (NRS); who have not undergone previous surgery in the lumbar region; who have no skin lesions; who do not have a pacemaker; who have not used medication for low back pain relief within 48 hours prior to the intervention; who are not undergoing treatment for low back pain; and who agree to participate in the research by signing the Informed Consent Form	Develop a health disorder during the study. Present allergic reactions to the electrical current generated by the therapeutic resource	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-9qm8wqh	Remote Monitoring for Pelvic Floor Muscle Strengthening in Pregnant Diabetic Women	Not yet recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7270	Use of Telemonitoring to Train the pelvic floor muscles of Diabetic pregnant women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Maternidade Escola Januário Cicco	https://ensaiosclinicos.gov.br/rg/RBR-9qm8wqh	<NULL>	Women; age between 18 and 45 years; diagnosis of Gestational Diabetes Mellitus, according to the criteria of the World Health Organization; gestational age between 14 and 21 weeks identified by first-trimester ultrasound; having attended a maximum of three consultations in High-Risk Prenatal Care; medical clearance to perform exercise; access to a smartphone; interest in participating in any of the interventions	Prescription of insulin therapy upon recruitment; multiple pregnancy; chronic arterial hypertension at recruitment; pre-eclampsia at recruitment; history of intrauterine fetal death or multiple miscarriages; orthopedic limitation; alcohol consumption doses of alcohol per week; smoking; neurological, language, hearing and/or visual limitations that may make participation in the study difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-783g4zj	Evaluation of manual therapy technique in women with breast cancer during radiotherapy	Not yet recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7273	Evaluation of the safety and efficacy of manual therapy in women with breast cancer during the radiotherapy treatment period	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-19	Centro Estadual de Oncologia - CICAN	Fundação Oswaldo Cruz - FIOCRUZ/ Instituto Gonçalo Moniz - IGM	https://ensaiosclinicos.gov.br/rg/RBR-783g4zj	<NULL>	Women with breast cancer; over 18 years old; treated surgically with conservative surgeries; mastectomy; with or without axillary dissection and referral for adjuvant radiotherapy sessions with moderate hypofractionation (conformational technique - 3D); who respond to the DASH questionnaire; the care questionnaire; will be included in the study; with the skin; to the Free and Informed Consent Form (ICF) and Image Use Authorization Term	Women who have difficulty understanding or answering the questionnaires used; patients undergoing immediate breast reconstruction; problems or orthopedic surgeries on the ipsilateral limb; grade 3-4 radiodermatitis; referred for 2D conventional radiotherapy and intensity modulated radiotherapy (IMRT) sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-10mk5gvb	Efficacy and safety of the combined use of a bioestimulator and ultrasound for improvement of facial sagging	Not yet recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7277	Efficacy and safety of the combined use of Poly-L-lactic acid and Microfocused Ultrasound for improvement of Facial Sagging: a randomized, triple-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-15	Fernanda Almeida Nunes Castro	Angioderm Centro de Estética Ltda	https://ensaiosclinicos.gov.br/rg/RBR-10mk5gvb	<NULL>	Healthy women, 35 and 50 years old, with mild to moderate facial laxity.	facial surgical scar; history of herpes simplex infection; active or systemic infection;  non-steroidal anti-inflammatory drugs use; anticoagulants use; steroids use; heparin; vitamin K or E within the last 30 days prior to the study; pregnancy; breastfeeding; any clinical condition and or laboratory abnormality; previous aesthetic procedures with biostimulators or physical resources such as laser, radiofrequency and or ultrasound on the face in the last 3 years; injection of permanent materials in the face anytime	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-4j5ph5m	Evaluation of the reduction of dental whitening time to control dental sensitivity in adolescents	Not yet recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7278	Evaluation of reducing dental bleaching time to control dental sensitivity in adolescents: double blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4j5ph5m	<NULL>	good general and oral health; be between 12 and 16 years old; at least six upper front teeth free of active caries and endodontic treatment; Canines (13,23) should be A2 color or darker.	Patients undergoing orthodontic treatment; patients with dental prostheses; severe tooth discoloration (tetracycline stains, fluorosis or devitalized teeth); pregnant and lactating patients; participants who have already undergone teeth whitening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-656kdr2	Efficacy of Diaphragmatic Release on airflow in individuals with Parkinson&apos;s Disease: randomized controlled clinical trial	Not yet recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7284	Study of the effect of the Myofascial Release Technique of the diaphragm on the airflow of individuals with Parkinson&apos;s Disease: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-656kdr2	<NULL>	Adult men and women (over 18 years old); with early-stage Parkinson&apos;s Disease (PD) (modified Hoen &amp; Yahr scale 0-2.5); undergoing regular pharmacological medical treatment for PD with the use of Levodopa; physical and understanding conditions for carrying out the research; no smoking; absence of respiratory diseases or other diagnosed neurological diseases	Participants who miss 3 continuous sessions and those who are unable to perform the tests properly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-9q6yb9p	Effects of protein supplementation on body composition of obese women with breast cancer undergoing chemotherapy	Not yet recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7287	Effects of supplementation with isolated whey protein on the body composition of obese women with breast cancer undergoing chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Centro Estadual de Oncologia	Fundação Oswaldo Cruz - Fiocruz Bahia	https://ensaiosclinicos.gov.br/rg/RBR-9q6yb9p	<NULL>	Women; aged &gt;=18 years; diagnosed with invasive breast carcinoma stages I to III; already initiated neoadjuvant or adjuvant systemic chemotherapy treatment; Body Mass Index (BMI) &gt;=30kg/m2	Women diagnosed with associated metastasis; severe obesity (BMI &gt;=40kg/m2); allergy to milk proteins; conditions that affect body water composition such as edema; conditions that affect muscle mass such as muscular dystrophy; limb amputation; pregnancy; use of pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-29xt8nh	Use of the Etonogestrel implant in women with kidney transplant to prevent pregnancy.	Not yet recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7290	Etonogestrel Implant in Kidney Transplant	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Irmandade da Santa Casa de Misericórdia de Porto Alegre	Irmandade da Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-29xt8nh	<NULL>	Kidney transplant women between 14 and 49 years old; carry out follow-up at the Gynecology outpatient clinic of Santa Casa de Porto Alegre; desire for etonogestrel implant insertion	Kidney transplant less than 6 months ago; use of medroxyprogesterone in the last 6 months; patients in organ rejection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-3b3fc72	Evaluation of the effect of using Adjustable Tables on Posture problems, Body Pain, and Caloric Expenditure in high school adolescents: a crossover clinical trial	Not yet recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7293	Evaluation of the effect of using Standing Desks on Postural Deviations, Musculoskeletal Pain symptoms, and Energy Expenditure in high school adolescents: a crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal do Rio Grande (FURG)	Universidade Federal do Rio Grande (FURG)	https://ensaiosclinicos.gov.br/rg/RBR-3b3fc72	<NULL>	Second year high school students; aged 14 to 21; both sexes; duly enrolled in the year 2024 at the Federal Institute of Rio Grande do Sul - IFRS, Rio Grande campus; who agree to participate in the study	Students with physical and/or cognitive limitations that prevent them from completing self-administered questionnaires and carrying out physical assessments and postural assessments on their own; students who are pregnant or breastfeeding;  students outside the age range of 14 to 21	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-10kn9x8f	Effect of the association of Amitriptyline or Jambu with lidocaine and Prilocaine	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7294	Evaluation of the association of Amitriptyline or Acmella Oleracea with Lidocaine and Prilocaine nanocapsules in topical anesthesia: randomized, crossover clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2024-10-05	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10kn9x8f	<NULL>	Age 18 or older and under 30 years old. Both genders. Undergraduate and graduate students of the Piracicaba School of Dentistry. Having accepted and signed the Free and Informed Consent Form - Healthy individuals; those who do not present any type of comorbidity that could generate any risk to the volunteer during the study and do not use continuous medications. Previous experience with local anesthesia, previously with an anesthetic agent of the same class (amide), thus, we can state that they have already had topical use of a similar drug without negative responses. Absence of history of allergy or complications resulting from local anesthetic. Who does not use medications that alter the perception of pain. Upper premolars (14 and 24) healthy on both sides (absence of restorations). Responsive to the Pulp Tester electrical stimulus, an electrical impulse emitting device, called Pulp Tester (PTE) will be used	Pregnant women. Breastfeeding women. Under 18 years of age and 30 years of age or older. Refusal to adhere to treatment using topical drugs. Reporting allergies to any component of the formula. Taking antidepressants, anticonvulsants and anti-inflammatories. Presence of inflammation in the region. Being under direct supervision of researchers (developing some type of activity in undergraduate or graduate studies)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-6bczsb6	How Electromassage can help patients with Hematological Cancers: a study on sensory aspects and well-being	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7297	Effects of Electromassage on Perceptual Aspects of Hematooncology patients: a non-randomized clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6bczsb6	<NULL>	Individuals of both male and female ages between 18 and 59 years old; diagnosis of hematological cancer; being treated for hematological cancer; and, medical clearance to participate in the research	Patients with the presence of metastasis; exacerbated diseases (e.g. severe cardiovascular or respiratory diseases); contraindication for the use of electromassage: loss of sensitivity, acute skin injuries and/or devitalized skin; and poor general health that makes it impossible to carry out all assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-88c4zpy	Assessment of skin acceptability with perceived efficacy for both adults and children	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7299	ORC_110114_EN24-0215-01_Dermal acceptability assessment with perceived efficacy and Dermal and pediatric acceptability assessment with perceived efficacy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-09	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-88c4zpy	<NULL>	Inclusion Criteria group I participant of both sexes aged 18 and 60; participants with mouth ulcers; participants with mild gingivitis; participants who use orthodontic appliances and/or removable prostheses; be a user of products in the same category; participants willing to follow the trial procedures, who have a cell phone capable of use and with access to the internet network and are available for telephone contacts and/or via WhatsApp and teleservices, with internet access on the days and times determined for the assessments ; participants willing to attend the Clinical Research Center for evaluations, if necessary; participants must understand and agree to the Free and Informed Consent Form (e-TCLE) and consent to their participation; group II participants of both sexes aged between 6 months and 1 year; participants in the first teething phase; vaccination card (updated and up to date); intact skin of the analysis region; be a user of products in the same category; parents or legal representative willing to follow the trial procedures, who have a cell phone capable of use and with access to the internet network and are available for contact by telephone and/or via WhatsApp and teleservice, with internet access on determined days and times for assessments; parents or legal representative of participants willing to attend the Clinical Research Center for evaluations, if necessary, parents or legal representatives of participants must understand, agree and sign the Free and Informed Consent Form (e-TCLE)	Pregnancy or risk of pregnancy/lactation (when women) – for group I; use of anti inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the assessment of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); history of allergies to medical products; active skin pathologies and/or lesions (local and/or disseminated) in the assessment area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; relevant or current clinical history of evidence of alcohol or other drug abuse (for group I); known history or suspected intolerance to products in the same category; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; intense sun exposure up to 15 days before the assessment; employees or children of employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher to be reasonable for disqualification from participation in the study; If yes, it should be described in observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-5pb2g33	Non-Invasive Head Electrical Stimulation Combined With Physical Exercise for Individuals With Knee Pain for More than Three Months	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7305	Analysis of the application of Transcranial Direct Current Stimulation combined with an Exercise protocol on Pain and Physical Function outcomes in individuals with Knee Osteoarthritis: A randomized, controlled, blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-05	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5pb2g33	<NULL>	Female individuals; Score pain at least three on the numerical pain scale; Not undergoing physiotherapy treatment for at least sixty days	History of epilepsy; Metal devices implanted in the skull; Significant psychiatric or neurological illnesses that prevent the patient from responding to the study assessment instruments; Being pregnant; Having undergone some type of infiltration in the knee joint in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-8f8dsqg	Evaluation of a universal adhesive containing naringin in non-carious cervical lesion restorations: a clinical trial.	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7306	Evaluation of the clinical longevity of a universal adhesive system containing nanoencapsulated naringin in self-etch mode in non-carious cervical lesion restorations: a double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8f8dsqg	<NULL>	Participants with good general health; participants aged over 18 years to 70 years; men and women; acceptable level of oral hygiene; participants must present at least 20 teeth in occlusion; 20 teeth in function; no active clasps from removable partial dentures on the included teeth; the teeth should not be abutments for prostheses; absence of periodontal disease; no active carious lesions; no parafunctional habits; participants should have at least two non-carious cervical lesions to be restored in different teeth; the lesions should be non-retentive; lesions deeper than 1 mm; lesions that involve both enamel and dentin of vital teeth; and the cavosurface margin should not involve more than 50% of the enamel	Participants with extremely poor oral hygiene; participants using orthodontic devices; participants with severe or chronic periodontitis; participants with parafunctional habits; participants with known allergies to resin-based materials or any other materials used in this study; pregnant women; breastfeeding women; participants on chronic use of anti-inflammatories, analgesics, and psychotropics; participants who have difficulty attending follow-up appointments after the restoration will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-10rvpcp3	Immediate Effect of Osteopathic Manipulative Treatment on ankle movement and gait in Individuals with dorsiflexion limitation	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7307	Acute effect of Osteopathic Manipulative Treatment on ankle range of motion and spatio-temporal and kinematic gait variables in individuals with limited dorsiflexion: pragmatic crossover randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10rvpcp3	<NULL>	Non-pregnant adult subjects; aged between 18 and 40 years; with ankle dorsiflexion limitation measured by the Weight Bearing Lunge Test (Lunge Test); who have never undergone manipulative treatment or manual therapies; without ankle and/or foot surgery, ankle sprains in the last 6 months; without a diagnosis of neurological disease; who agree to participate in the study by signing the informed consent form	Participants who present with acute musculoskeletal and osteoarticular conditions in the lower limbs on the day of the assessment and intervention will be excluded, with acute musculoskeletal and osteoarticular conditions in the lower limbs defined as those for which participants are using analgesics and anti-inflammatory medications to control pain and the inflammatory process; conditions that interfere with gait or standing position	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-65tyfff	Prevention program of Lip, Oral Cavity, and Oropharyngeal Cancer: intervention and costs of the program	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7309	Prevention Program of Oral Cavity, Lip and Oropharyngeal Cancer: intervention process and cost-effectiveness	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal de Goiás	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-65tyfff	<NULL>	Dentists, phisians, nurses, nursing technicians, dental assistants, and community health agents working in primary health care units and secondary care professionals, selected according to planning with the SMS-Goiania team. Risk group for individuals aged 40 years or older, smokers, those exposed to the sun for more than 2 hours daily, and those with a history of sexually transmitted diseases	Individuals who do not agree to participate in the research and those under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-7g99bx3	Manual therapy to relieve postpartum shoulder pain	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7310	The effect of manual therapy to relieve pain in the shoulder girdle in the immediate postpartum period: series of 10 cases	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-28	Universidade Santa Cecília	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-7g99bx3	<NULL>	Lactating women in the immediate postpartum period, between the second and third day postpartum; admitted to the Guilherme Álvaro Hospital; arising from a high-risk pregnancy; primiparous; from 18 years of age; presence of pain in the region of the shoulder girdle and/or breasts, without the presence of breast complications (breast engorgement, breast fissure, mastitis, blockage of the ducts and breast abscess); postpartum women who have signed the Free and Informed Consent Form	Presence of impairment of the shoulder girdle in the previous period and/or during pregnancy, such as: muscle and/or joint injury, dislocation or subluxation, tendinopathy(ies), infection and local surgery(ies); breastfeeding woman with a history of benign breast disease, breast cancer, Paget&apos;s disease and breast cyst; previous breast surgery (breast reconstruction and silicone prosthesis); cognitive deficit; use of medications that depress the central nervous system; desire to give up studying	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-3jxmntz	Educational proposal for the Birthing workshop methodology for health professionals	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7315	Psychoeducational Proposal of the Birthing workshop methodology for primary care professionals	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-12	Universidade Santa Cecília - UNISANTA	Secretaria Municipal de Saúde de Santos	https://ensaiosclinicos.gov.br/rg/RBR-3jxmntz	<NULL>	For primary health care professionals - work directly in prenatal care for pregnant women; work in the health units proposed in the study; be 18 and over; agreement to participate in the research and signature of the Free and Informed Consent Form (ICF) - health professionals For postpartum women - having received prenatal care at the health units participating in the present study; nulliparous; be 18 and over; agreement to participate in the research and signature of the TCLE for postpartum women	Withdrawal from participating in the study at any time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-93gmjsz	The use of Laser Therapy (ILIB) in pain and improvement of quality of life of patients with Rheumatoid Arthritis	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7316	Analysis of the effectiveness of Laser Therapy (ILIB) for pain, kinesiophobia, handgrip strength and impact on the quality of life of patients with Rheumatoid Arthritis: planned and controlled clinical trial	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2024-09-15	Faculdade de Enfermagem e Medicina Nova Esperança	Faculdade de Enfermagem e Medicina Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-93gmjsz	<NULL>	People with rheumatoid arthritis; aged between 35 and 75 years; both genders; with joint signs and symptoms lasting at least three months; able to fill out the Informed Consent Form	People with juvenile idiopathic arthritis; pregnancy; collagenous tissue diseases; chronic infectious disease; severe acute or chronic underlying disease; with changes in clotting factors; with hemorrhages; glaucoma; pregnant women; with a malignant tumor or cancer and missing more than 25% of irradiation treatment sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-62w99vg	Relationship between motor distraction and Transcranial Direct Current Stimulation in handgrip	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7317	Influence of isometric contraction of the index finger on contralateral palmar grip strength (overflow) in patients after Stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-04	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-62w99vg	<NULL>	Healthy adults; with a diagnosis of ischemic stroke confirmed by computed tomography or magnetic resonance imaging, between 3 weeks and 1 year after the stroke; of both sexes; aged between 18 and 59 years old	Individuals with any metal in the cranial cavity; injuries in the electrode placement area; with joint deformity in the upper and lower limbs; previous skull, eye or decompression surgery; severe cognitive impairment on the mini mental state examination scale (MMSE); uncontrolled epileptic seizure; in addition to clinical instability; global aphasia; previous visual disturbances; amputation of limbs; other associated neurological diseases or pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-2rsmbsf	The effects of a Zumba Dance and Mat Pilates in women post Breast Cancer Surgery	Not yet recruiting	Intervention	2024-09-06	<NULL>	<NULL>	7320	The effects of a Zumba Dance and Mat Pilates protocol in women post Breast Cancer Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2rsmbsf	<NULL>	Age over 18 years; females; who have undergone surgery to remove the tumor; undergoing chemotherapy and/or radiotherapy and/or hormonal treatment and/or immunotherapy; who have completed chemotherapy and/or radiotherapy and/or hormonal treatment and/or immunotherapy within a maximum period of 5 years; sedentary and non-sedentary; normal body mass index, overweight, or obesity class I; availability of time to undergo the offered protocols; capacity for understanding	Refusal to receive the protocol; pregnant women; amputation of one or more upper and/or lower limbs; neurological disorders with cognitive impairments or movement difficulties; decompensated heart diseases; severe metastases limiting functional status; and failure to respond to three contact attempts by the researcher for scheduling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-28swytb	Use of Dexmedetomidine as an auxiliary medication in nerve blocks to control pain in hip surgery: randomized clinical study	Not yet recruiting	Intervention	2024-09-09	<NULL>	<NULL>	7322	Use of Dexmedetomidine as an adjuvant in Peng Block for hip surgery: randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-28swytb	<NULL>	Patients indicated for hip surgery under spinal anesthesia; of both sexes; aged between 18 and 85 years; ASA classification (American Society of Anesthesiology) I, II and III	Patient refusal; known sensitivity or contraindication to local anesthetics or dexmedetomidine; history of psychological disorders; localized infection at the blockage site; use of anticoagulants/coagulopathies (platelet count &lt; 80,000 or  international normalized ratio (INR) &gt; 1.5)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-8r96g87	Importance of oral health guidance for pregnant women	Not yet recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7325	Evaluation of prenatal dental care efficacy on oral health literacy of pregnant women: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8r96g87	<NULL>	Pregnant; second trimester of pregnancy; own a smartphone	High-risk pregnancy; third trimester of pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-78934cv	Potential of Resveratrol as an auxiliary treatment for type 2 Diabetes Mellitus	Not yet recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7326	Effect of Resveratrol on the metabolic profile of individuals with type 2 Diabetes Dellitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-78934cv	<NULL>	The following inclusion criteria will be used to recruit individuals: (1) diagnosed with type 2 diabetes mellitus; (2) aged between 18 and 59 years; (3) undergoing oral hypoglycemic treatment or combination therapy for at least 6 months; (4) not undergoing any antioxidant therapy such as vitamin supplements; and (5) not being allergic to the components present in the treatments	Patients with type 1 diabetes, pregnant women, lactating women and patients with severe heart disease, liver disease and renal failure will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8yp7h7k	Immunonutrition and mental factors in recovery after Stomach Cancer surgery	Not yet recruiting	Observational	2024-09-11	<NULL>	<NULL>	7331	Immunonutrition and psychosocial factors in the recovery of patients after Gastric Cancer surgery: a multidimensional analysis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8yp7h7k	<NULL>	Adult or elderly patients; age 18 or older; both genders; undergoing gastric cancer surgery who used immunonutrition	Patients with pre-existing hematologic diseases that might affect blood count results; patients with other malignancies, and those with a history of psychological disorders that impair their ability to respond to the study questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8rwbb77	Effect of Laser Light associated with Corticosteroid irrigation in controlling inflammatory manifestations in lower third molar extractions - a randomized clinical trial	Not yet recruiting	Intervention	2024-09-15	<NULL>	<NULL>	7343	Effect of Photobiomodulation associated with Hydrocortisone irrigation for the control of inflammatory manifestations in the extraction of impacted lower third molars – a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-26	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8rwbb77	<NULL>	Eligibility criteria will include participants who: are between 18 and 40 years old, are not pregnant, require bilateral extraction of lower third molars with a similar degree of bone impaction, have no systemic diseases or local conditions that could interfere with the tissue repair process, undergo a surgical procedure lasting up to 60 minutes, have no contraindications to the use of hydrocortisone, have no history of hypersensitivity to mepivacaine, dipyrone, and ibuprofen, have the presence of upper and lower central incisors, and have no light hypersensitivity	Exclusion criteria will include participants under 18 or over 40 years of age, participants who are pregnant, procedures that exceed 60 minutes in duration, trans-surgical complications (e.g., hemorrhage or fainting), participants who do not follow up within the proposed interval or do not return for the second extraction, participants who report using medications other than those provided by the research team, use of anesthetics exceeding the amount outlined in this study (2 cartridges), as well as the absence of upper and lower central incisors, a history of hypersensitivity to mepivacaine, dipyrone, and ibuprofen, and light hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-5kcyrnq	Effect of a strength training program for abdominal muscles on performance in multidirectional jumps	Not yet recruiting	Intervention	2024-09-16	<NULL>	<NULL>	7345	Strength training for CORE muscles and performance in multidirectional jumps: implications for training and rehabilitation in sports	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidade Federal do Pampa - Campus Uruguaiana	Universidade Federal do Pampa - Campus Uruguaiana	https://ensaiosclinicos.gov.br/rg/RBR-5kcyrnq	<NULL>	Male and female; age between 18 and 35 years; recreational practice in sports involving jumping; who have not had delayed onset muscle pain and ligament or muscle injuries in the lower limb in the last 6 months	Body mass index greater than 30 kg/m²; musculoskeletal and/or vestibular problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-10zh7737	LevantAE! APP: reducing sedentary lifestyle in obese patients before bariatric surgery	Not yet recruiting	Intervention	2024-09-17	<NULL>	<NULL>	7349	Reducing sedentary time in Obese individuals pre-bariatric surgery at a teaching hospital: using the “Levantae! App”	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Centro de Ciências da Saúde	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10zh7737	<NULL>	Men and women; aged 18 years or older up to 59 years old; body mass index ≥ 30kg/m2; not participating in any physical exercise program; being properly monitored at the general surgery outpatient clinic of the Hospital das Clínicas of the Federal University of Pernambuco; being able to understand and use the application; having their own smartphone with a data package capable of installing the application; residing in the metropolitan region of Recife	Have contraindications for practicing physical activities; patients with severe arthritis, fibromyalgia or any other type of disease that prevents them from performing any type of physical activity; do not use the application for at least 70% of the stipulated period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-868rxjt	Effect of bonding on the performance of veneers	Not yet recruiting	Intervention	2024-09-17	<NULL>	<NULL>	7350	Effect of the kind of cement on the performance composite veneer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-868rxjt	<NULL>	An upper or lower anterior tooth (incisor or canine) requiring indirect veneer restoration; presence of antagonists and neighboring teeth making contact, good oral health; age between 18 and 70 years; both genders	Extensive coronary destruction that contraindicates a veneer restoration; teeth with spontaneous or constant pain indicative of irreversible pulpitis; presence of periapical lesions; severe systemic disease; allergy to restorative materials; periodontal disease; bruxism; harmful parafunctional habits; history of hypersensitivity in the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-55z5hzf	Study of the potentiation of propofol sedation by dipyrone	Not yet recruiting	Intervention	2024-09-18	<NULL>	<NULL>	7353	The role of Dipyrone as an adjuvant in the Sedation of adult patients with Propofol: Randomized, double blind and crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Associação Evangélica Beneficente de Londrina  - AEBEL	Anestesioclinica de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-55z5hzf	<NULL>	Both sexes; 18-60 years old; American Society of Anesthesiologists (ASA)  I and II functional classification	Personal history of allergic or pseudoallergic reactions to dipyrone; propofol and/or lidocaine; pregnant women; regular use of benzodiazepine medications; current history of chemical dependency; children; elderly (&gt;60 years); ASA functional classification &gt; II	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8h6tk9z	Evaluation of the use of Auriculotherapy to improve pain in Tumor Wounds in patients undergoing palliative care	Not yet recruiting	Intervention	2024-09-19	<NULL>	<NULL>	7357	Evaluation of the effects of Auriculotherapy to control pain in lesions or tumor wounds in patients with advanced cancer undergoing palliative care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-03	Instituto Nacional do Câncer	Instituto Nacional do Câncer	https://ensaiosclinicos.gov.br/rg/RBR-8h6tk9z	<NULL>	Patients of both sexes in palliative care enrolled at the Cancer Hospital Unit Four (HCIV); patients with pain symptoms of a minimum intensity of four points on the Edmonton Symptom Assessment System (ESAS) scale in the wound/tumor lesion (LFT) located in the skin, breast, head and neck, genitals, rectum or anal canal; patients with FLT staging record (1, 1N, 2, 3 and 4); patients at least 20 years old; patients with (KARNOFSKY PERFORMANCE STATUS SCALE (KPS) greater than 30%, therefore responsive; patients agreeing to sign the Informed Consent Form (ICF)	Patients with injuries to both ear pinnae; patients with adhesive plaster allergy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-99h2qmf	Effect of Vitamin E in pregnant women with Severe Preeclampsia	Not yet recruiting	Intervention	2024-09-23	<NULL>	<NULL>	7369	Vitamin E Supplementation in pregnant women with Severe Preeclampsia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Departamento de Análises Clínicas e Toxicológicas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-99h2qmf	<NULL>	Pregnant women aged ≥ 18 years, diagnosed with severe preeclampsia, defined as systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥110 mmHg or the presence of other clinical and laboratory alterations, such as: severe headache, chest pain, dyspnea, O2 saturation &lt;97%, leukocytosis, thrombocytopenia, elevated creatinine and uric acid, nausea, vomiting, epigastric pain, elevated bilirubin, plasma albumin, low non-reactive cardiotocography, oligohydramnios, umbilical artery Doppler with absent or reversed dialysis flow, will be included. The inclusion criteria also include pregnant women with inadequate levels of serum alpha tocopherol (≤ 30 mmol), from the 20th gestational week, with a single fetus and followed up at the high-risk multidisciplinary prenatal outpatient clinic at the Januário Cicco Maternity Hospital	Women with a previous or current diagnosis of Diabetes Mellitus or Gestational Diabetes Mellitus, cases of multiple pregnancies, pregnant women who smoke, have allergies or are taking supplements containing vitamin E above 50 IU, who are using illicit drugs or alcohol during the current pregnancy, have fetal abnormalities, have documented uterine bleeding within one week of screening, have pregnancies resulting from in vitro fertilization, have thrombophilia, are carriers of Human Immunodeficiency Virus, syphilis and systemic lupus erythematosus will be excluded from this study. Women with serum tocopherol levels &gt; 30 mmol/L and whose delivery does not take place at the Januário Cicco Maternity Hospital will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-2bgcvwj	Intravitreal injection of dexamethasone disodium phosphate as a predictor of response to intravitreal dexamethasone implant in diabetic macular edema refractory to anti-VEGF therapy	Not yet recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7376	Intravitreal injection of dexamethasone disodium phosphate 2 mg/mL as a predictor of response to dexamethasone 0.7 mg intravitreal implant in diabetic macular edema refractory to anti-VEGF therapy	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2bgcvwj	<NULL>	(1) age 18 years or older; (2) diagnosis of diabetes mellitus for at least 5 years; (3) presence of refractory diabetic macular edema defined as central macular thickness (diabetic macular edema [DME]) &gt;300 μm caused by intraretinal or subretinal fluid and a &lt;10% reduction in DME from baseline 1 month after at least three monthly intravitreal anti-VEGF (bevacizumab, ranibizumab, or aflibercept) injections, as measured by spectral-domain optical coherence tomography (SD-OCT); (4) best-corrected visual acuity (BCVA) between 1.3 (20/400) and 0.2 (20/32) LogMAR; and (5) history of uncomplicated ipsilateral cataract surgery with intraocular lens implantation; (6) both genders	(1) any diabetic macular edema (DME) treatment in the last 4 months; (2) panretinal photocoagulation (PRP) in the last 6 months; (3) any ophthalmic surgery performed in the last 4 months; (4) history of pars plana vitrectomy (PPV); (5) history of open-angle glaucoma or corticosteroid-induced elevated intraocular pressure requiring antiglaucoma or antihypertensive ocular treatment; (6) intraocular pressure &gt;= 21 mmHg; (7) history of allergy to any product used in the procedure; (8) presence of tractional retinal detachment affecting the fovea	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-26cnqdt	Effect of resistance training with different exercises on muscle strength and selective hypertrophy of the quadriceps femoris	Not yet recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7377	Chronic effect of different exercises on strength and selective hypertrophy of the quadriceps femoris	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-26cnqdt	<NULL>	Men; university students; aged between 18 and 35 years; body mass index less than 30 kg/m2; physically active; no restrictions on the practice of physical exercise; with previous experience in resistance training but who have not been training in the last six months; no history of osteomyoarticular injury of the lower limbs in the last twelve months; who have not used any ergogenic resource in the last twelve months	Subjects who do not achieve 85% adherence to training sessions; use supplements; engage in other high-intensity counter-resistance activities during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-2sgn9cy	Effectiveness of educational software in the teaching-learning of nursing students on infant development	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7379	Effectiveness of Wise Infant Development® software in the acquisition of knowledge about infant development among nursing students: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal do Ceará	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-2sgn9cy	<NULL>	Both sexes; be at least 18 years old; be regularly enrolled in the educational institution; be a nursing student; not currently taking or having taken the child health course; have basic computer skills	Students absent due to medical leave or maternity leave; students who are already nursing technicians; obtain a score equal to or greater than 70% in the pre-test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6cr3b2w	Short-term effects of different weekly frequencies of Strength Training on the Subjective Perceptions of Elderly People: A randomized crossover trial	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7380	Short-term effects of different weekly frequencies of Strength Training on Perceptive Responses of dwelling Elderly People: A randomized cross trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidade Federal Rural de Pernambuco	Programa Academia da Cidade, polo Cavouco	https://ensaiosclinicos.gov.br/rg/RBR-6cr3b2w	<NULL>	People of both genders; at least 60 years of age; have not practiced physical activity for at least six months; do not have disabling diseases that imply a risk for participating in the physical training program; do not have a diagnosis of cognitive impairments or mental health disorders that prevent them from understanding and assuming the commitments of the study	Participants who have a limiting health condition will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-3fnbr78	Evaluation of a Bioactive Gel for controlling Tooth Sensitivity after dental whitening using 6% Hydrogen Peroxide in adolescents	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7381	Evaluation of the effectiveness of a Bioactive Gel to control Dental Sensitivity after tooth whitening using 6% Hydrogen Peroxide in adolescents: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-23	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3fnbr78	<NULL>	Good general and oral health; ages between 12 and 16 years; both sexes; have at least six upper front teeth free of active caries and endodontic treatment; canines (13,23) should be A2 color or darker	Participants undergoing orthodontic treatment; use of dental prostheses; severe tooth discoloration (tetracycline stains, fluorosis or devitalized teeth; pregnant and lactating women; patients who have already undergone tooth whitening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-5wr5kw5	The effects of Dry Needling on Delayed Muscle Pain in healthy women	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7384	The effects of Dry Needling on Delayed Muscle Pain in healthy women:  a sham-controlled randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-25	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	https://ensaiosclinicos.gov.br/rg/RBR-5wr5kw5	<NULL>	Feminine gender; be between 18 and 28 years of age; considered active according to the characterization of the International Physical Activity Questionnaire Short Version (IPAQ); perform physical activity involving upper limbs at least twice per week; present integrity of the shoulder, elbow and hand joints of the member non-dominant; no history of musculoskeletal injury in the assessed limb, in the last 6 months, nor neurological, visual and/or auditory deficits adjusted; no regional sensitivity disorder; do not use anticoagulants; not have needle phobia; no previous experience using dry needling	Not correctly carrying out assessment procedures; do not attend any stages of the research; carry out another type of intervention for muscle recovery during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-10fpnsh5	Risk scores Respiratory Risk Assessment in Surgical Patients in Catalonia - ARISCAT, American Society of Anesthesiologists - ASA, Local Assessment of Ventilatory Management During General Anesthesia for Surgery - LAS VEGAS and the incidence of postoperative pulmonary complications in patients undergoing thoracic surgery	Not yet recruiting	Observational	2024-09-27	<NULL>	<NULL>	7386	ARISCAT, ASA and LAS VEGAS risk scores and the incidence of postoperative pulmonary complications in patients undergoing thoracic surgery with single-lung ventilation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10fpnsh5	<NULL>	All patients over 18 years of age; both genders;  undergoing non-cardiac thoracic surgery and with single-lung ventilation	Patients undergoing thoracic cardiac surgeries; patients under 18 years of age; pregnant women; patient refusal; contraindications to the proposed surgical, anesthetic or analgesic techniques; sepsis; psychiatric illness; uncontrolled endocrine, renal or hepatic disease; coagulopathies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-4q22z7y	Exploring medical education in Brazil: an investigation into anesthesiology competencies	Not yet recruiting	Intervention	2024-09-28	<NULL>	<NULL>	7387	Teaching anesthesiology competencies in Brazil: from general practitioners and family doctors to anesthesiology specialists	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Hospital Universitário Gaffree e Guinle/HUGG da Universidade Federal do Estado do Rio de Janeiro - UNIRIO	Hospital Universitário Gaffree e Guinle/HUGG da Universidade Federal do Estado do Rio de Janeiro - UNIRIO	https://ensaiosclinicos.gov.br/rg/RBR-4q22z7y	<NULL>	Individuals of all genders aged over 18; for semi-structured interviews, participants must be physicians with a specialization or medical residency degree; for questionnaires on anesthesiology, socioeconomic, and professional profiles, participants must be physicians enrolled in a medical residency or specialization program; for the use of the teaching software, participants must be medical students between the eighth and twelfth periods or members of an anesthesiology academic league	Being a minor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-2k3zczn	Vaginal Massage by Hand or Device to Treat Women with Pain During Sex	Not yet recruiting	Intervention	2024-10-02	<NULL>	<NULL>	7394	Manual or Instrumental Perineal Massage to treat women with Sexual Pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-05	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2k3zczn	<NULL>	Over 18 years; who has already experienced sexual intercourse with vaginal penetration; meets the Diagnostic and Statistical Manual of Mental Disorders criteria for genitopelvic on penetration pain disorder; and has pelvic floor muscles hypertonia verified by vaginal palpation	Women with diagnosed neuromuscular disease will be excluded; pregnant; symptoms of urinary tract infection at the time of assessment; pain triggered after a surgical procedure; already menopausal women; women who cannot tolerate perineal and intravaginal touch; previous trauma or fracture in the pelvic area; neurological or cognitive diseases that hinder or prevent a full understanding of the procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-10k3srtd	Subproject 2: Effectiveness of Mobile Application in Preventing Falls in the hospital	Not yet recruiting	Intervention	2024-10-02	<NULL>	<NULL>	7395	Effectiveness of Educational Technology to Prevent Falls in the hospital: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10k3srtd	<NULL>	Being 18 years of age or older; having been admitted to the institution for more than 12 hours; being literate; having a smartphone and/or another mobile device, such as a tablet; obtaining minimum scores in the Mini Mental State Examination, with the cut-off points: 21 for those with between one and three years of schooling, 24 for people with between four and seven years of formal education, and 26 for people with more than eight years of schooling	Patients with scheduled discharge; those with incapacitating mental illness; dementia; or those who present hemodynamic instability at the time of recruitment will be excluded; which will be assessed by assessing the patients&apos; vital signs, already carried out by professionals in the study sectors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-5t8k6qz	Comic Books and the impact on adolescents&apos; Knowledge and Skills in Basic Life Support: a randomized controlled trial	Not yet recruiting	Intervention	2024-10-03	<NULL>	<NULL>	7397	Effectiveness of Comic Stories on the Knowledge and Skills of adolescents about Basic Life Support: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-04	Universidade Federal do PIauí	Universidade Federal do PIauí	https://ensaiosclinicos.gov.br/rg/RBR-5t8k6qz	<NULL>	Being a teenager; both genders; aged 10 to 19 years old	have professional training in the health area; have completed a Basic Life Support (BLS) course (less than 1 year ago); be expected to be away from work during the data collection period; have participated in the construction and validation stage of the Comic Book (HQ); have a self-reported limitation that makes it impossible to participate in the lecture class, in reading the Comic Book HQ or in developing Basic Life Support maneuvers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-6vfbzj6	Validation of the questionnaire for Portuguese (Brazil) and evaluation of the effect of the Posthumous Dignity Therapy intervention in bereaved informal caregivers	Not yet recruiting	Intervention	2023-07-14	<NULL>	<NULL>	7407	Posthumous Dignity Therapy: validation of the questionnaire for Portuguese (Brazil) and evaluation of the effect of the dignity therapy intervention in bereaved informal caregivers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Instituto de Câncer de Londrina	Instituto de Câncer de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-6vfbzj6	<NULL>	Bereaved informal caregivers of patients cared for by the Oncology Palliative Care Team at the Londrina Cancer Hospital; informal caregivers of patients in the active death process or who have already died cared for by the Team; over 18 years of age of both genders; previously elected by patients or the healthcare team as the patients’ main caregivers; who write, speak or read Brazilian Portuguese; with cognitive capacity to understand questions and answers, which will be evaluated by the researcher; willing to meet researchers for up to 3 consecutive meetings at an interval of approximately 45 days in total, in person or online	Previous or ongoing psychiatric disorders; caregivers presenting criteria for diagnosis of depression using the PHQ-9 questionnaire (9-item Patient Health Questionnaire), which will be applied before the TCLE (Informed Consent Form), with the aim of screening for suicidal ideation or depression	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-9q8pknt	Non-contact Heart Rate Monitoring via Webcam during Rest and Virtual Reality Activities in people with Cerebral Palsy	Not yet recruiting	Intervention	2024-10-08	<NULL>	<NULL>	7412	Contactless Heart Rate Monitoring based on Photoplethysmography using Webcam during Rest and Virtual Reality Activities in People with Cerebral Palsy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	https://ensaiosclinicos.gov.br/rg/RBR-9q8pknt	<NULL>	Children and adults with Cerebral Palsy will be included in the study; of both sexes; with a minimum age of 5 years and no maximum age limit; with Gross Motor Function Classification System level I to V and Manual Skill Classification System level I to V	Participants unable to understand the activity; unable to carry out the instructions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3tt2zhz	Comparison of recovery after addition of a medication to spinal anesthesia in patients undergoing uterine removal	Not yet recruiting	Intervention	2024-10-09	<NULL>	<NULL>	7415	Quality of recovery after hysterectomy surgery with the use of clonidine in spinal anesthesia	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tt2zhz	<NULL>	age between 18 and 65 years; woman; underwent abdominal hysterectomy; american society of anesthesiology physical status 1 and 2	illiterate; contraindication to any medication used in the research; refusal to spinal anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-58986zm	Cognitive rehabilitation program for patients with long COVID	Not yet recruiting	Intervention	2024-10-11	<NULL>	<NULL>	7424	Characterization of Neuropsychiatric, Neuropsychological, Radiological and Biological Findings of COVID-19 Infection in the Central Nervous System: a Cohort Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-18	Instituto de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo	Núcleo de Inovação Tecnológica – InovaHC	https://ensaiosclinicos.gov.br/rg/RBR-58986zm	<NULL>	Individuals aged 18 or over, with a history of hospitalization due to COVID-19, who present complaints about their cognition demonstrated by performance below expectations in clinical assessments two years after hospital discharge.	Individuals with intellectual disabilities; individuals with severe visual and/or motor difficulties; and participants with less than eight hours of exposure to the game.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3vcy2qq	Modulation of pain, muscle function and viscoelastic properties through PENS in paralympic athletes	Not yet recruiting	Intervention	2024-10-14	<NULL>	<NULL>	7428	Improving the diagnosis of myofascial pain syndrome in athletes paralympics through the application of multiple parameters and the acute effects of Percutaneous Electrical Nerve Stimulation (PENS)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-20	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3vcy2qq	<NULL>	Paralympic athletes selected based on convenience and the evaluator’s judgment; athletes participating in sports with high physical demands on the upper limbs; both sexes; age over 18; having a myofascial trigger point being diagnosed through clinical examination; have participated in competitions at state level; national or international in the last year	Signs of cervical radiculopathy and positive Spurling test; severe cervical regenerative disc disease; direct trauma to the dorsal cervical region or shoulder in the last 90 days; major depression; suspected cancer; complete tear of the rotator cuff muscles; antiplatelet or anticoagulant therapies other than aspirin; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-5yzdx8g	Evaluation of the safety and efficacy of Doctive® lollipop in the treatment of Denture Stomatitis	Not yet recruiting	Intervention	2024-10-18	<NULL>	<NULL>	7439	Evaluation of the safety and efficacy of Doctive® for the treatment of Denture Stomatitis: a randomized double-blind clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-12-30	Faculdade de Odontologia da Universidade Federal de Goiás	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5yzdx8g	<NULL>	Patients using upper total dentures (PT) with a clinical diagnosis of Denture Stomatitis; over 18 years old; both sexes; with autonomy and ability to understand the purpose of the treatment and availability to voluntarily collaborate with the research	Patients allergic to any component of the DOCTIVE® formulation; immunocompromised; who have recently made continuous use of systemic or topical intraoral antifungals; patients who have recently made use of broad-spectrum antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-7y89mh3	Transcranial electrical stimulation can improve pain intensity, cardiac activity, brain and muscle activity in a person with low back pain	Not yet recruiting	Intervention	2024-10-18	<NULL>	<NULL>	7440	Effect of transcranial electrical stimulation pain parameters, cardiac variability, brain and muscle electrical activity for the treatment of chronic non-specific low back pain: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-09	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7y89mh3	<NULL>	Presence of non-specific low back pain confirmed by the roland morris disability questionnaire; age group over 18 years old; availability to attend the research site during the study period; both genders	Pregnant; person with seizure; pacemaker; open wound at the application site; cancer; deep vein thrombosis; epilepsy; spinal canal stenosis; radiculopathy; spondylolisthesis; scoliosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-6zvxsdb	Effect of an intervention with Electrical Stimulation of the brain through the skull bones associated with Motor Exercises on motor symptoms in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2024-10-21	<NULL>	<NULL>	7444	Effect of an intervention with Electrical Stimulation on the brain through the skull bones combined with exercises on locomotion and balance in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6zvxsdb	<NULL>	Individuals with Parkinson&apos;s Disease; of both sexes; they must have the disease diagnosed by doctors following the criteria determined by the London Brain Bank; age equal to or greater than 50 years; and present independent locomotion (without assistance from people or use of auxiliary devices)	Staging greater than 3 on the Hoehn &amp; Yahr scale; orthopedic and vision problems that make it impossible to comply with the experimental protocol; presence of another neurological disease, in addition to Parkinson&apos;s Disease (PD); indicative of cognitive decline (score less than 24 on the Mini Mental State Examination - MMSE); individuals at risk of receiving Transcranial Direct Current Stimulation - tDCS (e.g., neural implants, individuals with deep brain stimulation implants, pacemaker, history of seizures and epilepsy); have uncontrolled diseases (e.g. high blood pressure and diabetes); experience intense pain or discomfort that makes it impossible and difficult to perform motor exercises; and not understanding the motor exercises proposed in the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-5f7x539	Assessment of skin irritability after using a health product	Not yet recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7448	ORC_115312_EN24-0384-01 - Assessment of Primary Dermal Irritability, Cumulative Dermal Irritability and Dermal Sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5f7x539	<NULL>	Participants of both sexes; aged 18 to 70 years; skin of the application region integrates; agreeing to follow the test procedures and to attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consent and signing of the Free and Informed Consent Term (ICF)	Pregnancy or risk of pregnancy and/or lactation; use of anti-inflammatory drugs and/or immunosuppressive drugs for up to three months before selection; immunosuppression by drugs or active disease; decompensated endocrinopathies; Personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; expect intense exposure to sunlight or tanning sessions during the study period; provision of bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitization to topical products; active skin pathologies (local and/or disseminated) that may interfere with the study results; skin reactivity; use of new drugs/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in study products (test or comparative product); history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-5454tsk	Effect of Pilates and Walking on the pelvic muscles of postmenopausal women	Not yet recruiting	Intervention	2024-10-23	<NULL>	<NULL>	7453	Effects of Pilates and Aerobic Exercise on the pelvic floor musculature in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5454tsk	<NULL>	Postmenopausal woman with 1 to 10 years of amenorrhea; having a cardiometabolic condition (hypertension, diabetes, high cholesterol, or being overweight); and having a medical clearance to engage in physical activities	Have physical problems or cardiovascular complications that prevent them from performing physical exercises; a history of stroke or acute myocardial infarction; renal pathologies; use medications that affect lipid metabolism; are smokers; have intolerance to vaginal palpation and/or the insertion of a pressure manometer; presence of neurological and/or cognitive impairments that hinder understanding of the proposed procedures; undergoing physical therapy for pelvic floor dysfunctions  before and during the participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-7c4c5jx	Comparing Benzodiazepine-Ketamine and Benzodiazepine-Fentanyl sedation in Cataract surgery	Not yet recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7454	Comparison between Benzodiazepine associated with Ketamine versus Benzodiazepine associated with Fentanyl in Phacoemulsification	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-10-31	Hospital Oftalmológico de Brasília	Hospital Oftalmológico de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7c4c5jx	<NULL>	Patients undergoing phacoemulsification at HOBrasil, Salvador, Bahia; at least 18 years old; of both genders	Patients under 18 years of age; pregnant patients; patients with chronic pain syndrome; patients with hypersensitivity to any of the tested medications or the topical anesthesia used; patients with communication difficulties (significant hearing loss, speech impairments, aphasias); patients with physical status determined by the American Society of Anesthesiologists  classification of III-VI	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-286pv6k	Clinical evaluation of color compatibility between monochromatic composite resin and the tooth after dental whitening	Not yet recruiting	Intervention	2024-10-23	<NULL>	<NULL>	7455	Evaluation of color compatibility of monochromatic composite resin with the tooth after in-office bleaching - randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-286pv6k	<NULL>	Age between 18 and 60 years; in good general and oral health; presenting healthy upper canines with color variation A3 to D4 on the Vita scale; no pain or pulp alteration in the tooth to be whitened; consent to participate in the research; both sexes	Use of fixed orthodontic appliances; active periodontal disease; endodontic treatment on the upper anterior teeth; pregnant patients; smokers; presence of cavities or restoration in the tooth to be whitened	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-1094zfg5	Assessment of patient satisfaction with different types of periodontal probes	Not yet recruiting	Intervention	2024-10-24	<NULL>	<NULL>	7456	Assessment of patient satisfaction with periodontal probes: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-1094zfg5	<NULL>	Age between 18 and 60 years; absence of gingival inflammation or periodontal disease; consent to participate in the research; both genders	Self-reported systemic disease; smokers, pregnant women and those with dentin hypersensitivity; patient using non-steroidal anti-inflammatory drugs and analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-3vr6nq8	Use of SecurAcath and Cyanoacrylate Glue for prevention of Peripheral Insertion Central Catheters Dislodgement in Children: a clinical study	Not yet recruiting	Intervention	2024-10-24	<NULL>	<NULL>	7457	Securacath and Cyanoacrylate Glue in reducing Central Venous Catheters Displacement in children: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-30	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-3vr6nq8	<NULL>	Child or adolescent; both sexes; age range between 0 days and incomplete 15 years of age; indication for insertion of Peripherally Inserted Central Catheter equal to or greater than 2.8 French; child or adolescent scheduled for hospital follow-up	Children or adolescents or their guardians who request the withdrawal of their data from the research after the research data collection protocol has begun or at its end; children or adolescents allocated to the Experimental Group and for whom, by decision of the professional at the time of insertion of the peripherally inserted central catheter, it was not possible to use the SecurAcath® or Cyanoacrylate Glue devices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-76xg97x	Evaluation and satisfaction of methods for labor induction	Not yet recruiting	Intervention	2024-10-29	<NULL>	<NULL>	7464	Interventions for improving success rates and satisfaction in labor induction: B.O.M. study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Hospital da Mulher Professor Doutor José Aristodemo Pinotti da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-76xg97x	<NULL>	Women above 18 years old; nulliparous and multiparous women; gestational age of 37 weeks or more; single pregnancy; cephalic presentation; intact membranes; bishop score of 6 or less; and cervical dilation of 2 centimeters or less	Patients who have any contraindication to vaginal birth; category 3 fetal heart rate tracking; presence of hemolysis; elevated liver enzymes and low platelet syndrome (HELLP); eclampsia; growth restriction below the 10th percentile (Hadlock growth curves) with reversed flow in doppler studies of the umbilical artery; restriction below the 5th percentile with elevated, absent, or reversed flow on doppler studies of the umbilical artery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-8hkzzxn	The effects of home exercise guidance on improving strength and mobility in older adults cancer patients	Not yet recruiting	Intervention	2024-10-31	<NULL>	<NULL>	7467	The effects of home exercise guidance on improving strength and functional mobility in older adults cancer patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital de Clínicas da Faculdade de Medicina de Ribeirão Preto	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8hkzzxn	<NULL>	Individuals of both sexes. over 60 years old. diagnosed with cancer. Who are under follow-up at the Hospital das Clínicas de Ribeirão Preto in the Geriatric Oncology Outpatient Clinic. capable of using a cell phone for telephonic follow-up or having a companion and/or caregiver to assist the older adult in accessing treatment	A low score on cognitive screening using the 10-point Cognitive Screener (10-CS); according to the level of education; neurological disease; bone metastasis; palliative care; decompensated cardiovascular disease; or blood pressure equal to or greater than 160/90mmHg	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-35qcc8f	The Effects of Pilates on Menopausal Women on Urine Loss, Heart Health and Sleep Quality	Not yet recruiting	Intervention	2024-11-04	<NULL>	<NULL>	7481	The effects of Mat Pilates in postmenopausal women with Stress Urinary Incontinence, Cardiovascular Risks and Sleep Quality: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-05-04	Faculdade de Educação Física e Fisioterapia - Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia - Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-35qcc8f	<NULL>	Women after menopause; aged between 45 and 65 years; have stress urinary incontinence; if you have high blood pressure, it must be controlled; have a Body Mass Index (BMI) between 25 and 35; be sedentary or perform less than 150 minutes of physical activity per week; pelvic floor muscle strength greater than or equal to 2 on the modified Oxford pelvic floor scale	Not knowing how to read and not being able to answer the questionnaires; having a urinary tract infection at the time of treatment; feeling pain during sexual intercourse during penetration and/or constipation; using hormone therapy; being a smoker; having undergone any previous pelvic surgery (including surgery for stress urinary incontinence, with the exception of cesarean section); not having undergone previous pelvic radiotherapy; having a neurological disease; having only Urgency Urinary Incontinence or Overactive Bladder Syndrome; using beta-blockers; not accepting to participate in the research and/or not signing the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:15
RBR-6p76t5x	Efficacy of a profissional use paste with PRG technology in reducing Dental Plaque in children with Molar-Incisor Hypomineralization (MIH)	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7485	Efficacy of a prophylactic paste with PRG technology in reducing Dental Plaque index in children with Molar-Incisor Hypomineralization (MIH): an in situ and in vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6p76t5x	<NULL>	Minimum age of 7 and maximum age of 17 years; both sexes; diagnosis of Molar-Incisor Hypomineralization (MIH); signature of the Informed Consent Form (ICF) by the legal guardian and the Informed Assent Form (IAF) by the participant; high biofilm accumulation and poor oral hygiene	Presence of syndromes or general health conditions that prevent a complete clinical examination; children who do not allow the procedure; use of fixed appliances or metal bands that may interfere with the clinical examination of all tooth surfaces; children who are illiterate or semi-literate; patients requiring emergency treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-10p45rdg	Evaluation of the benefit of a new psychotherapy applied to students at the Federal University of Rio Grande do Norte in controlling Anxiety and Depression Symptoms through specific questionnaires for anxiety and depression and laboratory tests	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7486	Assessment of the efficacy of a novel brief psychotherapy technique applied to students at the Federal University of Rio Grande do Norte in controlling Anxious and Depressive Symptoms through specific questionnaires and biomarkers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Empresa Brasileira de Servicios Hospitalares - EBSERH	Empresa Brasileira de Servicios Hospitalares - EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-10p45rdg	<NULL>	Students from the Federal University of Rio Grande do Norte attending the outpatient clinic in the Mental Health Unit  within the Clinical Medicine Department, Psychiatry Division, at the Onofre Lopes University Hospital; If on antipsychotics, the use must be stable, with no changes in psychotropic medications in the past 6 weeks; both sexes will be included without age limit	Drug use or substance dependence; smokers;  alcohol consumption; recent physical exercise within the past 48 hours; sleep of less than 7 hours the night before sample collection; imminent risk of suicide; schizophrenia; psychotic symptoms; bipolar disorder;  for women use of oral contraceptives or pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-5gqgs99	Effects of a Walking Program associated with Blood Flow Restriction on strength, muscle thickness, and gait in individuals with leg strength imbalance	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7488	Effects of a Walking Program associated with Partial Blood Flow Restriction on muscular and functional aspects in individuals with muscle strength asymmetry in lower limbs	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-20	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5gqgs99	<NULL>	Individuals aged between 18 and 59 years; muscle strength difference between lower limbs greater than or equal to 10 per cent in the knee extensor musculature (quadriceps), indicating asymmetry; medical clearance for training, granted by the physician associated with the study (Dr. Francisco Wekerlin Morozowski); signing the Informed Consent Form; completing 75 per cent of the proposed training sessions if selected for the intervention	Having conditions that prevent the completion of questionnaires, understanding of instructions, and performance of tests (e.g., severe vestibular deficits, mobility deficits, and cognitive impairment); having systolic blood pressure greater than or equal to 140 mmHg or diastolic blood pressure greater than or equal to 90 mmHg; having more than one risk factor for thromboembolism, which includes: body mass index greater than or equal to 30 kg/m². diagnosis of chronic inflammatory disease. history of pelvic, hip, and femur fractures. major surgeries in the last 6 months. diagnosis of varicose veins in the last 6 months. family history of deep vein thrombosis and pulmonary embolism. use of oral contraceptives. tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-9fcpncq	ORC_128436_EN24-0540-03_Analysis of the Acceptance and Perceived Effectiveness of a Product for Maintaining Intimate pH	Not yet recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7498	ORC_128436_EN24-0540-03_Gynecological Acceptability Assessment and pH Maintenance with Perceived Efficacy	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-01-09	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9fcpncq	<NULL>	Female population; female participants aged 18 to 60 years; participants with an active sex life; participants with a pH value between 3.8 and 4.5; heterosexual couples through stable union or civil marriage; intact skin in the area of analysis of the product (vaginal mucosa); must be users of products in the same category; agreement to follow the study procedures and attend the Clinical Research Center on the specified days and times for evaluations; understanding, consent, and signing of the Informed Consent Form (ICF); male population; male participants aged 18 to 60 years; heterosexual couples through stable union or civil marriage; intact skin in the area of analysis of the product (penile region); must be users of products in the same category; agreement to follow the study procedures and attend the Clinical Research Center on the specified days and times for evaluations; understanding, consent, and signing of the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and/or lactation (for women); sexually transmitted infections, such as candidiasis, trichomoniasis, or conditions that compromise the safety evaluation of the product; use of anti-inflammatory drugs, immunosuppressants, or antihistamines up to 3 weeks before selection; skin markings in the experimental area that interfere with the evaluation of possible skin reactions, such as vascular malformations, scars, increased hair growth, numerous nevi, or sunburns; atopic or allergic history to products in the same category; active skin pathologies or lesions (local or disseminated) in the evaluation area; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or drug abuse; known or suspected intolerance to products in the same category; intense sun exposure up to 15 days before evaluation; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; other conditions deemed reasonable by the investigator for disqualification from participation in the study, which should be described in the clinical record observation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-98vwvvy	EN23-0216-01 Skin Reaction and Sensitivity Test for a Product	Not yet recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7499	EN23-0216-01 Evaluation of Primary Dermal Irritability, Cumulative Dermal Irritability, and Dermal Sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-27	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-98vwvvy	<NULL>	Participants of both sexes aged 18 to 70 years; skin Phototype: I, II, III, and IV (according to the adapted Fitzpatrick scale); intact skin in the application area; agreement to follow the trial procedures and attend the clinic on the specified days and times for medical evaluations and for the application and reading of dressings; understanding, consenting to, and signing the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and/or lactation (for women); use of anti-inflammatory drugs within 30 days and/or immunosuppressive drugs up to three months prior to selection; immunosuppression due to drugs or active diseases; uncontrolled endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before evaluation or during the study period; planned intense sun exposure or tanning sessions during the study period; planned sea bathing, swimming, or sauna use during the study; participation in water sports during the study; dermographism; use of oral or topical vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 3 weeks prior to selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation, or photosensitization to topical products; active skin conditions (local and/or widespread) that could interfere with study results; skin reactivity; use of new medications/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to any ingredient of the study products (test or comparator products); history of non-compliance or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable grounds for disqualification from the study; if so, this should be noted in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-32b24ck	The effect of supplementation of the nutrient Coenzyme Q10 in the treatment of Dermatological Wounds in people with Type 2 Diabetes Mellitus	Not yet recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7504	Evaluation of Coenzyme Q10 supplementation on the development of Dermatological Wound healing in individuals with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Federal de Juíz de Fora Campus GV	Universidade Vale do Rio Doce	https://ensaiosclinicos.gov.br/rg/RBR-32b24ck	<NULL>	People aged 18 years or older; of both sexes; people with confirmed diagnosis of type 2 diabetes mellitus and with dermatological lesions	People with generalized edema, pregnant women, breastfeeding women, who cannot perform anthropometric assessment, with amputated limbs or with some type of mental or physical disability; individuals with intrinsic vulnerability who have difficulty understanding their decisions due to a mental disorder, chemical dependency or neurological disease; people who consume antioxidant or omega 3 supplements and anticoagulants; smoking people	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3s6fk6j	Effect of electrical stimulation applied to the left ear associated with physical training on a bicycle in people with high blood pressure	Not yet recruiting	Intervention	2024-11-12	<NULL>	<NULL>	7506	Effects of Noninvasive Vagus Nerve Stimulation and Aerobic Exercise on Blood Pressure, Cardiac Autonomic Modulation, Inflammation and Functional Capacity in Hypertensive Patients: a controlled, randomized, blinded clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Associação Educacional Nove de Julho	Associação Educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-3s6fk6j	<NULL>	Individuals of both genders diagnosed with mild to moderate hypertension (Stages I and II); over 18 years of age; who use a maximum of 3 classes of drugs; hypertensive individuals with systolic blood pressure (SBP) levels of 140 to 160 mmHg and diastolic blood pressure (DBP) of 90 to 100 mmHg; hypertensive individuals physically fit to perform exercises and with medical clearance for the activity	Individuals with contraindications for the use of vagus nerve stimulation (cochlear implant, metals or skin lesions at the application site); Individuals with a history of ischemic stroke, coronary disease, chronic obstructive or restrictive pulmonary disease, peripheral arterial disease, hyper or hypothyroidism, chronic atrial fibrillation, Diabetes Mellitus, immunodependent, chronic kidney disease on dialysis; Individuals using antihypertensives (beta blockers); pregnant women; Individuals with cardiac pacemakers; Individuals who do not complete all training and who do not perform post-intervention evaluations will be excluded from the final analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3bgyznp	Oral irrigators and the protection of dental implants: results from a study on oral hygiene and patient health	Not yet recruiting	Observational	2024-11-13	<NULL>	<NULL>	7509	Effect of the adjunctive use of oral irrigators on the Peri-Implant Condition in individuals under Maintenance Therapy: prospective study on clinical, microbiological, and immunological aspects	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3bgyznp	<NULL>	Patients of both genders; non-smokers or former smokers; non-diabetic; absence of other systemic diseases that would impede periodontal and peri-implant clinical examination; no continuous use of systemic antimicrobials or anti-inflammatory medications in the two months before periodontal and peri-implant examinations; dentate individuals with fixed prosthetic rehabilitations on implants	Participants with inadequate adherence to the use of interdental brushes or oral irrigators; individuals who developed diabetes during the study; individuals under continuous use of corticosteroids; individuals who resumed smoking; participants with irregular attendance at periodontal and peri-implant maintenance therapy appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-8xtsgvv	Evaluation of Metabolic and Cardiovascular Risk markers in transgender men using Testosterone	Not yet recruiting	Observational	2024-11-14	<NULL>	<NULL>	7517	Evaluation of Metabolic, Inflammatory, Cardiovascular and Endothelial Risk markers in transgender men on Testosterone therapy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Federal de São Paulo - Escola Paulista de Medicina	Centro de Referência e Treinamento DST/AIDS-SP	https://ensaiosclinicos.gov.br/rg/RBR-8xtsgvv	<NULL>	Transgender men; 18 to 59 years old; no previous hormone therapy; or hormone therapy stopped at least 6 months before the begining of the study; willing to start testosterone therapy	Not being able to understand the protocol rules; not being able to attend the institution for the scheduled visits and laboratory exams	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-64jx632	Assessment of skin irritation after use of a medical device	Not yet recruiting	Intervention	2024-11-18	<NULL>	<NULL>	7519	ORC-131878_EN24-0608-01_Evaluation of primary skin irritability, cumulative skin irritability and skin sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-64jx632	<NULL>	Participants of both sexes; aged 18 to 70 years; phototype: I, II, III and IV; intact skin in the application region; agreement to follow the trial procedures and to attend the Center on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consenting to and signing the Free and Informed Consent Form	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs 30 days and/or immunosuppressive drugs for up to three months prior to selection; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days prior to the assessment or during the study period; anticipated sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month prior to the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks prior to selection; scheduled vaccination during the study period or up to 03 weeks prior to selection; history of sensitization, irritation or photosensitization to medical devices; active skin pathologies that may interfere with the results of the study; skin reactivity; use of new medications during the study; previous participation in studies with the same physician; congenital or acquired immunodeficiency; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to any ingredient of the study medical device; history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-79pss6w	Effect of Water with Ozone in the treatment of Pericoronitis	Not yet recruiting	Intervention	2024-11-22	<NULL>	<NULL>	7532	Effect of Ozonated Water as an adjunct in the treatment of Pericoronitis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal dos Vales do Jequitinhonha e MucurI	Universidade Federal dos Vales do Jequitinhonha e MucurI	https://ensaiosclinicos.gov.br/rg/RBR-79pss6w	<NULL>	Participants with signs/symptoms of pericoronaritis, such as the occurrence of spontaneous pain, erythema, purulent or draining edema, affecting the gingiva of the oral cavity, located over the lower third molar; age 18 to 35 years; both sexes; surgical risk level I and level II, according to the American Society of Anesthesiologists (ASA I and ASA II); periodontal status level I and II, according to the American Academy of Periodontology; consent to participate in this clinical trial by signing the Informed Consent Form (ICF)	Participants with surgical risk level III and level IV, according to the American Society of Anesthesiologists (ASA III and ASA IV); with periodontal status level IV, according to the American Academy of Periodontology; undergoing antibiotic therapy in the last two months; with any medical contraindication for periodontal probing; currently using tobacco and aged less than 18 years and more than 35 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9q35d6n	Clinical longevity of impression-made composite resin restorations and out-of-mouth restorations in destroyed teeth: a clinical study	Not yet recruiting	Intervention	2024-11-22	<NULL>	<NULL>	7533	Clinical longevity of composite resin restorations obtained by 3D printing and semi-direct restorations in extensively destroyed teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-30	Universidade Federal de Pelotas - Faculdade de Odontologia	Universidade Federal de Pelotas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-9q35d6n	<NULL>	Indicate extensive restoration in posterior teeth (molar and premolar); be in good general health to undergo dental treatment; and; agree to participate in the study by signing an informed consent form; both sexes	Patients who do not have at least 12 posterior teeth in occlusion; patients who are undergoing orthodontic treatment or planning to undergo orthodontic treatment; patients with a systemic disease that prevents dental treatment; patients not available for follow-up appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-2n2g2p5	Clinical evaluation of a chemical active composite in atraumatic restorative treatment in primary teeth: randomized, double-blind clinical trial	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7534	Clinical evaluation of a self-polymerizing composite in atraumatic restorative treatment in primary teeth: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2n2g2p5	<NULL>	Patients with one class II cavities  in deciduous molars; healthy and cooperative patients; patients between 4 and 8 years old; be male or female	Patients with systemic diseases; patients with erosion, bruxism and incisal wear; use of orthodontic appliances; allergy to the materials used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9yk239p	ORC-128436_EN24-0540-02_Skin Evaluation of Potential to Cause Irritation or Sensitivity When Exposed to Light	Not yet recruiting	Intervention	2024-11-25	<NULL>	<NULL>	7535	ORC-128436_EN24-0540-02_Dermatological Evaluation of Topical Photoirritant and Photosensitizing Potential	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9yk239p	<NULL>	Participants must be of both genders; aged between 18 and 70; have Fitzpatrick skin type II or III; intact skin in the product application area. They must agree to follow all study procedures; attend the Center on specified days and times for medical evaluations, applications, and patch readings; sign the Informed Consent Form (ICF), demonstrating full understanding and acceptance of the study conditions	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs in the last 30 days and/or immunosuppressive drugs up to three months before selection; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the evaluation or during the study period; anticipated sea bathing, pool use, or sauna sessions during the study; practice of aquatic sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to one month before the start of the study; aesthetic and/or dermatological treatment on the body within three weeks before selection; scheduled vaccination during the study period or up to three weeks before selection; history of sensitization, irritation, or photosensitization to topical products; active skin conditions (local and/or widespread) that could interfere with study results; skin reactivity; use of new medications during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or drug abuse; known history or suspected intolerance to any ingredient in the study product; history of non-adherence or unwillingness to follow the study protocol; previous history of conditions worsened or triggered by ultraviolet radiation; use of photosensitizing drugs; history or activity of photodermatoses; personal or family history of skin cancer; presence of precursor lesions for skin neoplasia, such as melanocytic nevi and actinic keratosis; use of new medications during the study; other conditions considered by the researcher as reasonable for disqualification from study participation, which must be described as a note in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-5sfqt7n	ORC-128436_EN24-0540-01_02_Evaluation of Skin Irritation and allergies	Not yet recruiting	Intervention	2024-11-25	<NULL>	<NULL>	7537	ORC-128436_EN24-0540-01_02_Primary Skin Irritability Evaluation, Irritability (HRIPT)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-25	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-5sfqt7n	<NULL>	Participants of both sexes aged 18 to 70 years. Phototype I, II, III, and IV according to the Fitzpatrick scale. Intact skin in the application area. Agreement to follow the trial procedures; attendance at the Center on the specified days and times for medical evaluations, applications, and patch readings. Understanding, consent, and signing of the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy/lactation. Use of anti-inflammatory drugs in the last 30 days and/or immunosuppressive drugs up to three months before selection. Immunosuppression due to drugs or active diseases. Uncompensated endocrinopathies. Personal history of atopy. Intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period. Planned exposure to sea baths, swimming pools, or saunas during the study. Practice of water sports during the study. Dermatographism. Use of oral or topical treatment with vitamin A acid and/or derivatives up to 1 month before the study start. Aesthetic and/or dermatological treatment on the body within 3 weeks prior to selection. Scheduled vaccination during the study period or up to 3 weeks before selection. History of sensitization, irritation, or photosensitization to topical products. Active skin conditions (local and/or widespread) that may interfere with the study results. Skin reactivity. Use of new medications during the study. Previous participation in studies with the same product. Congenital or acquired immunodeficiency. Relevant clinical history or current evidence of alcohol or other drug abuse. Known or suspected history of intolerance to any ingredient of the study product. History of non-adherence or unwillingness to adhere to the study protocol. Medcin employees or sponsor company employees involved in the study or immediate family members of an employee involved in the study. Other conditions considered reasonable by the researcher for disqualification from study participation being described in the observation section of the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-8ckxj5g	How the recovery of front teeth with implants by the unified health system works: evaluating efficiency in the dental trauma clinic	Not yet recruiting	Intervention	2024-11-27	<NULL>	<NULL>	7540	Implant rehabilitation protocols for anterior tooth loss in SUS patients: analysis of effectiveness associated with the dentoalveolar trauma clinic	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-05	Faculdade de Odontologia - Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8ckxj5g	<NULL>	Patient level: age greater than 18 and less than or equal to 60 years old; both genders; anterior tooth loss (single or multiple) or tooth with indicated extraction, assessed as sufficient for surgical planning; willingness to participate and sign informed consent. Implant site level: healed anterior edentulous space (at least 8 weeks since extraction), or tooth indicated for extraction due to fracture; coronary destruction with unfeasibility of recovery; minimum ridge dimensions of 5.4 mm (width) by 12 mm (height) in the anterior region of the maxilla, allowing the installation of implants with a regular or narrow diameter and a minimum length of 10 mm	Exclusion criteria at the patient level: inability to perform adequate oral hygiene or post operative care; inability to provide written informed consent and/or compliance with the study protocol; any contraindication to oral surgery, such as (but not limited to) uncontrolled diabetes, immunosuppression, radiation, chemotherapy or anti resorptive medication such as bisphosphonates; presence of multiple posterior edentulous spaces with an indication for extensive oral rehabilitation; heavy smoking with more than 20 cigarettes/day	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-5wnvtpk	Impact of bacterial vaginosis screening on the prevention of premature rupture of the amniotic sac and preterm birth in high-risk pregnancies	Not yet recruiting	Intervention	2024-11-27	<NULL>	<NULL>	7542	Impact of bacterial vaginosis screening on the prevention of premature rupture of membranes (PROM) and preterm birth (PTB) in high-risk pregnancies: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Faculdade de Medicina da Universidade Federal Fluminense	Faculdade de Medicina da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5wnvtpk	<NULL>	Pregnant women with less than 20 weeks of gestation; no age limit; with one or more risk factors for preterm birth or premature rupture of membranes, such as a previous history of preterm birth or premature rupture of membranes; cervical insufficiency; multifetal pregnancy; young maternal age; advanced maternal age; maternal Body Mass Index below 20; chronic or gestational diabetes; chronic or gestational hypertension	Inability to understand and sign the Informed Consent Form; presence of clinical signs of bacterial vaginosis, such as abnormal discharge; allergy to metronidazole	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-6c59zjb	Simultaneous TENS and exercises in knee Osteoarthritis	Not yet recruiting	Intervention	2024-11-30	<NULL>	<NULL>	7551	Previous photobiomodulation and Transcutaneous Electrical Nerve Stimulation simultaneously with therapeutic exercises in Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6c59zjb	<NULL>	Patients with knee osteoarthritis grades 2 and 3 on the Kellgren-Lawrence scale; with clinical and radiological diagnosis carried out by an independent traumatologist; age between 45 and 80 years; minimum pain of 3/10 in the numerical scale of pain; of both genders	Patients with knee osteoarthritis grades 0, 1 and 4 according to the Kellgren-Lawrence radiological classification; non-ambulatory patients; neurological diseases that lead to cognitive deficits that make it difficult to understand exercises; neuropathy; clinical manifestations that do not allow exercise; previous history of infiltration of the knee joint in the last three months; history of knee joint arthroplasty; history of knee trauma or surgery in the last six months; patients participating in another knee rehabilitation program; have undergone rehabilitation with or without transcutaneous electrical nerve stimulation (TENS) in the last 6 months; contraindications to TENS (pacemakers, dermatological lesions and changes in sensitivity in the knees); three consecutive unjustified absences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-10pzjmbj	Evaluation of the use of human milk in the growth and development of very low birth weight premature infants	Not yet recruiting	Intervention	2024-12-02	<NULL>	<NULL>	7553	Impact of nutritional therapy with pasteurized colostrum/hypercaloric human milk on perinatal outcomes of very low birth weight preterm infants: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-17	Departamento de Nutrição da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-10pzjmbj	<NULL>	Very low birth weight newborns (VLBN) of both sexes; on an enteral diet by orogastric tube, with mother&apos;s own expressed breast milk (LMO) and pasteurized human milk (LHP) from the milk bank	Neonates diagnosed with severe congenital malformations; with congenital errors of metabolism; with chromosomal disorders; with birth weight &lt; 700 g; with gestational age at birth &lt; 23 weeks; neonates prescribed a colostrum diet, high-calorie, transitional or mature LHP; in use of human milk additive	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-7nq5sqn	EN23-0216-04_Evaluation of skin irritation and allergy caused by light	Not yet recruiting	Observational	2024-12-03	<NULL>	<NULL>	7559	EN23-0216-04_Dermatological evaluation of topical phototoxicity and photosensitization potential	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-15	Universidade São Francisco	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7nq5sqn	<NULL>	Participants of both sexes; age between 18 and 70 years; phototype II or III (adapted Fitzpatrick scale); intact skin in the application area; agreement to follow the trial procedures; attendance at the clinic on scheduled dates and times for medical evaluations and application and reading of patches; understanding and signing of the Informed Consent Form (ICF)	Pregnant or breastfeeding women; use of anti-inflammatory drugs in the last 30 days and immunosuppressive drugs in the last three months; immunosuppression due to medication or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before or during the study; anticipated intense sun exposure or tanning sessions during the study; planned sea bathing, swimming pool, or sauna sessions during the study; practice of water sports; dermographism; use of oral or topical vitamin A acid treatments or derivatives up to one week before the study; aesthetic or dermatological treatments on the body within three weeks before the study; scheduled vaccination up to three weeks before or during the study; history of sensitivity, irritation, or photosensitization to topical products; active skin conditions that may interfere with the study results; use of new medications or cosmetics during the study; skin reactivity; congenital or acquired immunodeficiency; significant history or current evidence of alcohol or drug abuse; conditions aggravated by UV radiation; use of photosensitizing drugs; history or activity of photodermatoses; personal or family history of skin cancer; presence of precancerous skin lesions, such as melanocytic nevi and actinic keratoses; lack of adherence to the protocol; employees of Medcin or the sponsoring company involved in the study or close relatives of employees; other conditions considered by the researcher to disqualify participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-58wdpvh	Clinical profile, physical and sensory aspects of patients with Blood Cancer	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7561	Clinical profile, physical and perceptual aspects of Hemato-Oncology patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-58wdpvh	<NULL>	Both genders; age between 18 and 59 years old; diagnosis of hematological cancer; being treated for hematological cancer	Use of medications for pain, nausea or constipation before applying foot reflexology; present medical contraindication to practicing foot reflexology; pregnancy (1st trimester); diarrhea and/or vomiting; localized skin diseases on the feet; localized inflammation or edema in the feet;  fever; infectious diseases; extreme negative reaction to the application of foot reflexology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-4pk34zm	Clinical performance of restorations using fibers in teeth with treated canals: randomized clinical trial	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7562	Clinical performance of fiber-based restorations in endodontically treated teeth: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-16	Faculdade de Odontologia da Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4pk34zm	<NULL>	Being men and women; at least 18 years of age; in good general and oral health; the dental elements of the study must: have a posterior tooth, with satisfactory endodontic treatment; have loss of at least one proximal wall (occluso-mesial, occluso-distal, mesio-occluso-distal cavity); being in occlusion and having adjacent teeth; have a coronary structure remaining from the buccal or palatal/lingual walls with at least one cavity wall with a thickness of less than 2 mm	Patients with poor oral hygiene; smokers; pregnant women; breastfeeding women; teeth that have color changes due to intrinsic factors (dentinogenesis and amelogenesis imperfecta, fluorosis, tetracycline);  periodontal disease; severe parafunctional habits; cervical lesions (carious and non-carious); active clasps of removable partial dentures on the tooth included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-84gy8sc	Periwalking for labor analgesia. Comparative study between two anesthetics	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7564	Epidural Block with Ultra-low doses of Local  anesthetics (Periwalking) for Labor analgesia. Comparative study between 2  anesthetics	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-12-18	Hospital da Mulher Professor Doutor José Aristodemo Pinotti	Hospital da Mulher Professor Doutor José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-84gy8sc	<NULL>	Primiparas on active labor; patients classified as ASA 2 in accordance with the American Society of Anesthesiologists class 2; AGE higher than 18 yo; higher than 37 weeks of gestational age; single, live fetus with cephalic position; cervical dilation higher or equal than 6 cm; without previous cesarian section	Regional anesthesia contra-indication; alergic reactions with local anesthetics;ASA3 or more; psychiatry disorders; drugadiction; age below 18yo; Body mass index 40; fetus malformation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-9stskc6	Effect of Acupuncture on anxious symptoms of healthcare students with Generalized anxiety disorder: randomized controlled clinical trial	Not yet recruiting	Intervention	2024-12-04	<NULL>	<NULL>	7565	Effect of Acupuncture on anxious symptoms in healthcare students: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás	Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9stskc6	<NULL>	Students with symptoms of generalized anxiety even with conventional treatment (Generalized Anxiety Disorder Scale greater than 10); previous diagnosis by a psychiatrist according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders for generalized anxiety disorder; and students in the health area, regularly enrolled in the educational institution; over 18 years old; both sexes	Current psychosis and psychosis in the last 6 months; substance dependence in the last 6 months; severe depression that is significantly more relevant than generalized anxiety disorder; pregnancy or postpartum women; having undergone acupuncture treatment in the last 30 days; intolerance to acupuncture (needle phobia); students who are taking the subject of Acupuncture and Medical Homeopathy, and students who have completed less than 1 year of graduation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-9fjmcnp	Use of Bergamot Essential Oil to reduce Stress and Anxiety in public school teachers in Lajedo-PE: A clinical study	Not yet recruiting	Intervention	2024-12-04	<NULL>	<NULL>	7568	Use of Citrus bergamia Essential Oil in the management of Stress and Anxiety in public school teachers in the city of Lajedo-PE: A single-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-16	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9fjmcnp	<NULL>	Being a teacher in the public education network in the municipality of Lajedo-PE; be in full performance of their activities; be between 25 and 60 years old	People with upper airway obstruction problems at the time of the experiment; people with uncontrolled chronic respiratory diseases; people undergoing treatment with psychotropic medications or who have neurological and/or psychiatric comorbidities that affect cognition; people with a history of adverse reactions to aromatic products; present a score on the DASS-21 questionnaire, as defined by a score below 8 for anxiety and 15 for stress	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-45bk3sw	Efficacy of In-office Bleaching with Self-mixed reducing application time: a single-blind randomized clinical trial	Not yet recruiting	Intervention	2024-12-05	<NULL>	<NULL>	7571	Efficacy of in-office Bleaching using 35% Self-mixed Hydrogen Peroxide reducing application time: a single-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-45bk3sw	<NULL>	Volunteers aged at least 18 years; both sexes; with good general and oral health; with teeth free of caries and periodontal disease in the anterior region; who agree to the free and informed consent form (FICF) and whose canines must have A2 color or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Volunteers who have previously undergone a whitening procedure; who have reported the presence of previous dental sensitivity; presence of dental prosthesis; fixed orthodontic appliance; restorations in the upper anterior teeth; endodontic treatment in the upper anterior teeth; gingival recessions; teeth with tetracycline staining or fluorosis; continuous use of medications such as analgesics and anti-inflammatories; pregnant or lactating women and those with habits such as bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-3mcg82f	FotoBio-HIV: evaluation of Laser Therapy on Inflammatory, Immunological, and Coagulation Processes in People Living with HIV/AIDS	Not yet recruiting	Intervention	2024-12-05	<NULL>	<NULL>	7572	PhotoBio-HIV: evaluation of the effects of Vascular Photobiomodulation on Inflammatory, Immunological, and Coagulation Biomarkers in people living with HIV/AIDS – clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3mcg82f	<NULL>	Participants must have been diagnosed with HIV/AIDS for at least one year; be over 18 years of age; both sexes; be on regular antiretroviral therapy for at least six consecutive months; be in viral suppression (undetectable or less than the minimum limit); must not present active opportunistic infections at the time of study enrollment	People under 18; pregnant women; patients with active opportunistic infections; history of neoplasms; carriers of active electronic implants such as cardiac pacemakers; those with a history of epilepsy or seizures; people with known photosensitivity conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-6gr5kf	Phototherapy and blood flow restriction to protect against muscle damage	Not yet recruiting	Intervention	2020-02-19	<NULL>	<NULL>	7574	Photobiomodulation versus ischemia in protection against exercise-induced muscle damage: a clinical trial analyzing functional, perceptual and biochemical markers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-30	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-6gr5kf	<NULL>	Be a healthy male, aged 18-35 years and classified as irregularly active or active in the International Physical Activity Questionaire (IPAQ); Not being involved in strength training programs for upper limbs; not with a body mass index (BMI) of less than 18.5 kg / m-2 and greater than 30 kg / m-2; not be smokers or who use vasoactive medications and nutritional supplements regularly. Do not report musculoskeletal injury to lower limbs within 3 months prior to testing; not having uncontrolled diabetes mellitus or blood pressure; have no inflammatory rheumatologic condition or severe cardiovascular and / or pulmonary disease that prevents them from performing the evaluation and the proposed exercise; not having psychiatric disease and malignant tumors; not have presented Zika or Chikungunya in the last year	Missing some day of collection; at any time and for any reason expressing an intention to leave the study; present a health problem that prevents them from continuing to participate in the research; use of medications, electrotherapeutic equipment or other therapeutic resources to improve pain and performance during the collection period; practicing unusual or strenuous physical activities during the days of collection; Volunteers who smoke; history of alcohol or drug abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-6vnrmfn	Effect of Buriti supplementation compared to whey protein in healthy young adults undergoing physical exercise	Not yet recruiting	Intervention	2024-12-08	<NULL>	<NULL>	7579	Effect of Hyperproteic Supplementation Based on Buriti (Mauritia Flexuosa) Versus Whey Protein in Healthy Young Adults Undergoing Physical Exercise: A Randomized, Blind, Controlled Pilot Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-6vnrmfn	<NULL>	The study will enroll men and women; aged between 18 and 35 years; who are apparently healthy according to the criteria of the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+); and classified as insufficiently active or sedentary based on the International Physical Activity Questionnaire (IPAQ)	Individuals with musculoskeletal injuries that limit the capacity for moderate and vigorous exercise during the study period; neoplastic, hepatic, renal, or cardiovascular disorders; malabsorption disorders; those consuming anti-inflammatory drugs, analgesics, antibiotics, or vitamin and mineral supplements during the study period; individuals on medications affecting metabolic profile; and vegetarians will be excluded. Additional exclusion criteria will include pregnancy and breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-2tyjxf2	Comparison of two surgical techniques for treating recent achilles tendon injuries: a clinical study	Not yet recruiting	Intervention	2024-12-14	<NULL>	<NULL>	7590	Comparison of two Surgical techniques of Acute Injury Repair in the Achilles Tendon: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-02	Instituto de Ciências da Saúde da Universidade Federal do Pará - ICS/ UFPA	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-2tyjxf2	<NULL>	18 to 60 years old; both sexes; closed Achilles tendon injury with up to 21 days of evolution; non insertional Achilles tendon injury	Bilateral injury; history of previous surgery on the lower limb with injury; rerupture; diabetes mellitus; neurovascular disease; immunosuppressive therapy; use of drug from the fluoroquinolone group; patient who does not attend the return appointment; patient who does not follow the rehabilitation protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-98zsxkw	Efficacy of In-office Bleaching with an attachable syringe varying the application tip: double-blind randomized clinical trial	Not yet recruiting	Intervention	2024-12-17	<NULL>	<NULL>	7601	Efficacy of In-office Bleaching using 35% Hydrogen Peroxide in an attachable syringe varying the application tip: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-98zsxkw	<NULL>	Volunteers of both genders will be included in the study; with a minimum age of 18 years; with good general and oral health; with teeth free of carious lesions; gingival recessions and periodontal disease in the anterior region; who agree with the informed consent (ICF) and one of their canines must be A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Volunteers who have performed a bleaching procedure previously will be excluded from the study; who have reported the presence of previous tooth sensitivity; presence of dental prosthesis; fixed orthodontic appliance; restorations in maxillary anterior teeth; endodontic treatment in maxillary anterior teeth; gingival recessions; teeth with tetracycline staining or fluorosis; visible cracks in the teeth; continuous use of medications such as analgesics and anti-inflammatories; pregnant or lactating women and those with habits such as bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-3bhzqsm	Clinical trial to evaluate superior efficacy and safety of the association of Diltiazem hydrochloride 2% + Lidocaine hydrochloride 2% perianal gel in relation to Proctyl® rectal ointment (Policresulene 50 mg/g + Cinchocaine hydrochloride 10 mg/g) in the treatment of chronic Perianal Fissure	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7603	"DLG Protocol: Phase III, multicentre, single-blind, parallel, randomized clinical trial to evaluate the
superior efficacy and safety of the fixed-dose combination of diltiazem hydrochloride 2%
+ lidocaine hydrochloride 2% perianal gel compared to Proctyl® rectal ointment
(polyresulene 50 mg/g + cinchocaine hydrochloride 10 mg/g) in the treatment of chronic
perianal fissure"	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2024-12-20	Irmandade da Santa Casa de Misericórdia de Santos	Laboratórios Ferring LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-3bhzqsm	<NULL>	Participants capable of reading, or following along with the reading, understanding, and signing the informed consent form approved by the research ethics committee system; of both sexes; aged 18 years or older; capable of adequately communicating with the investigator and the clinical study team; diagnosed with chronic anal fissure; female participants without the potential to become pregnant; agree to use a safe contraceptive method; agree not to have anal intercourse during the study period	Participants diagnosed with malignant disease in the last 5 years, except for successfully treated basal cell carcinoma; those with chronic diseases on regular medication that, at the investigator’s discretion, may interfere with the clinical study; participants who show hypersensitivity or contraindication to any of the components of the formulations; female participants who are breastfeeding, planning to become pregnant, or who test positive for pregnancy during the study period; any clinical observation (clinical/physical evaluation) that is interpreted by the investigator as a risk to participation in the clinical study; participants who refuse to undergo visual or medical examination of the anal fissure; participants with more than one anal fissure; participants with anal fissure associated with or caused by other conditions, including but not limited to: drug-induced, trauma, human immunodeficiency virus (HIV) infection, anal fistula, inflammatory bowel disease, perianal sepsis, or malignancy; participants who refuse to discontinue all other concomitant topical preparations applied in and around the anus from the day before the start until the end of the clinical study; use of sitz baths from the signing of the informed consent form (ICF) until the end of the clinical study; use of anesthetics from the signing of the ICF until the end of the clinical study; injection of botulinum toxin into the anal fissure within 3 months prior to signing the ICF; participants actively treated with antiviral therapies for HIV (e.g., indinavir, nelfinavir, ritonavir); participants treated with any prohibited medication within 14 days prior to signing the ICF such as: cytochrome P450 (CYP450) inhibitors and inducers; cytochrome P3A4 (CYP3A4) substrates, inhibitors, and inducers; benzodiazepines; β-adrenoceptor antagonists (Beta-Blockers); calcium channel blockers; digoxin; opioids; participants with any of the following concomitant conditions: sick sinus syndrome, except in the presence of a functioning ventricular pacemaker; second or third-degree atrioventricular block, except in the presence of a functioning ventricular pacemaker; hypotension (systolic pressure less than 90 mmHg); history of reduced left ventricular function, bradycardia, first-degree atrioventricular block, or prolonged PR interval (&gt; 0.2 seconds / &gt; 200 milliseconds) on electrocardiogram; documented acute myocardial infarction and pulmonary congestion by radiography; history of active uncontrolled diabetes and/or hypertension; current infection treated with a macrolide antibiotic; clinical evidence or history of fecal incontinence; clinical evidence or history of chronic constipation or constipation in the 4 weeks prior to signing the ICF (defined as 2 or fewer bowel movements per week; associated with straining/passage of hard stools); clinical evidence or history of anal fistula; clinical evidence or history of anal abscess; clinical evidence or history of fixed anal fibrosis; history of inflammatory bowel disease or active gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn’s disease, ulcerative colitis); history of any previous anal or rectal surgery, including but not limited to: lateral sphincterotomy and anal dilation or other previous surgery involving the anal canal or perianal region; history of pelvic radiotherapy; participants with associated acute hemorrhoidal crises; participants with anal or perianal cancer; participants with a history of cardiac (any), renal (resection or renal agenesis), gastrointestinal (partial or total removal of the esophagus, stomach, duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, sigmoid colon, or rectum) and liver or pancreas surgery, as well as a history of transplantation; having any planned surgery that may interfere with the successful completion of the clinical study; participants who have received therapy with diltiazem hydrochloride gel or other topical calcium channel blockers or other topical medicinal ointments, which at the physician’s discretion may interfere with the outcome of the clinical study, 3 days before signing the ICF; participants using oral calcium channel blockers, nitrates (e.g., glyceryl trinitrate GTN), or any other vasodilators; any clinically significant condition of renal, hepatic, neurological, dermatological, immunological, psychiatric (including drug or alcohol users) or hematological disease or any clinically significant abnormal laboratory findings that, at the investigator’s discretion and from medical records, may compromise participation in the clinical study; presenting a positive preliminary drug test result for amphetamine/methamphetamine, opiate/morphine, marijuana/tetrahydrocannabinol, cocaine/benzoylecgonine, and/or benzodiazepine; research participants who have participated in clinical study protocols in the last 12 months (National Health Council Resolution CNS 251, August 7, 1997, item III, subitem J), unless there may be direct benefit to the research participant, at the investigator’s discretion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9vf9x3w	Effects of Osteopathic Manual Therapy (OMT) on the Stress levels of workers in a hospital environment	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7604	Effects of Osteopathic Treatment on Stress levels of workers in a hospital environment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-9vf9x3w	<NULL>	64 nurses and nursing technicians will be included; of both sexes; aged between 20 and 65 years old; all workers at the Polyclinic Hospital in the city of Cascavel/PR with at least six months of experience	All employees who are undergoing treatment with psychiatric medications will be excluded from this survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-2j9zqkz	Teledentistry vs. Traditional Care: Monitoring Oral Health in Homebound Older Adults in Primary Care	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7605	Oral Health Monitoring of Homebound Older Adults Using Teledentistry Versus Traditional Strategy by Oral Health Teams in Primary Care: A Pragmatic Randomized Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2j9zqkz	<NULL>	Both genders. Dentists: Must have an effective bond with the public health service, be hired through a selection process or linked to a multiprofessional residency program, have access to the internet via mobile device or computer with multimedia capabilities, and demonstrate availability to participate in the study, as well as a commitment to performing the proposed activities within the designated timeframe. Older Adults: Aged 60 or older, home-dwelling, monitored by oral health teams from the Family Health Strategy, with access to the internet (preferably via mobile device), and able to comprehend and respond to the proposed questions. For those older adults unable to comprehend and/or respond to the research questions, their caregivers (aged 18 or older) will be included. Caregivers of Older Adults: Whether laypersons or professionals, aged 18 or older, caring for older adults aged 60 or older, either home-dwelling or not, monitored by oral health teams from the Family Health Strategy, with access to the internet and able to comprehend and respond to the proposed questions	Dentists: Those on vacation, sick leave, leave of absence, retirement process, under administrative investigation, or members of inactive teams during the intervention phase of the research. Older Adults: Those who are out of their home at the time of data collection for any reason; those not receiving home visits; residents of Long-Term Care Facilities for the Elderly (ILPI); or those with caregivers younger than 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-2skg8p4	Effects of bodyweight physical training on the physical and mental health of military police officers from the special actions battalion	Not yet recruiting	Intervention	2024-12-19	<NULL>	<NULL>	7614	Effects of a bodyweight Physical Training protocol on the physical and mental health of military police officers from the special actions battalion	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2skg8p4	<NULL>	Military police officers from the 2nd Special Actions Battalion of the Military Police - BAEP de Santos; who agree to participate in the study; have worked in the military police for at least 1 year; do not have a previous psychiatric diagnosis; age between 26 and 50 years; male	Military police officers who use medicines that modulate the nervous system; and/or who present an attendance rate of less than 75% in the physical training sessions proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-9jw6tnm	Study of two different devices for bone augmentation	Not yet recruiting	Intervention	2024-12-20	<NULL>	<NULL>	7615	Barbell technique versus titanium reinforced PTFE membranes for bidirectional bone augmentation: multi-centre randomized clinical trial study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	https://ensaiosclinicos.gov.br/rg/RBR-9jw6tnm	<NULL>	Patients should have 18 years or older; signed inform consent; partial edentulism (up to 4 adjacent missing teeth); atrophied alveolar ridge with one or more adjacent missing teeth; atrophied alveolar ridge with residual remaining thickness less than 4mm; sufficient bone height at the surgical site to install implant	Patients with periodontal or peri-implant diseases; general contraindications for surgical procedures; inflammatory process / disease of oral cavity; dental implants adjacent to the surgical site; known or suspected non-compliance, drug or alcohol abuse; smokers or subjects who did not quit smoking at least 3 months before the surgery; diabetes; previous, concurrent or planned radiation therapy for head or neck cancer; concurrent or previous immunosuppressant, bisphosphonate, high-dose or long-term corticosteroid therapy; pregnant or lactating women; women of childbearing age, who are not using a highly effective method of birth control; participants in an investigational device, drug or biological study within the last 26 weeks prior to study start; participants in any other clinical investigation during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2y7jf2c	Efiicacy of at-home teeth bleaching comparing bleaching brush vs. tray-delivery  6% hydrogen peroxide	Not yet recruiting	Intervention	2024-12-20	<NULL>	<NULL>	7619	Efiicacy of brush-on vs. tray-delivery at-home bleaching with 6% hydrogen peroxide: A randomized, single-blind, split-mouth controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2y7jf2c	<NULL>	Patients should be 18 years or older; to be female;masculine;patients need to have a good general and oral health status;absence of caries lesions;restorations and endodontic treatment in the antero-inferior teeth;the lower canines should be color A2 or darker according to the value-oriented Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients already submitted to dental bleaching;undergoing orthodontic treatment;with severe discoloration due to tetracycline stains;fluorosis will not be included in the study;in addition;participants with any other pathology that may cause sensitivity;such as recession;dentin exposure;presence of visible cracks in the teeth;or history of hypersensitivity will also be excluded;additionally pregnant;lactating women;patients with dental bruxism;taking analgesic;anti-inflammatory drugs will not be included in the study sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-8w8rxbb	Assessment of Primary and Accumulated Dermal Irritability and Sensitivity of a cosmetic product	Not yet recruiting	Intervention	2024-12-21	<NULL>	<NULL>	7622	Assessment of Primary, Accumulated Dermal Irritability and Sensitization of a facial moisturizer, through patch testing (Patch Test)	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-21	IPCLIN - Instituto de Pesquisa Clínica Integrada Ltda	IPCLIN - Instituto de Pesquisa Clínica Integrada Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8w8rxbb	<NULL>	Full skin on the back;age from 18 to 59 years old;male and female;participants with phototypes I, II, III and IV according to the Fitzpatrick classification;absence of history of irritation and allergy to the material used in the study;have signed the free and informed consent form;participants who wish to participate in the study without financial profit	Participants who refuse to participate in the study in question;skin marks in the experimental area that interfere with the assessment of possible skin reactions,such as scars,increased hairiness,large quantities of ephelides and nevus and sunburn;active dermatoses that could interfere with the study results;pregnant or breastfeeding women;history of allergic reactions,irritation or intense sensations of discomfort to topical products such as cosmetics and medicines;volunteers with a history of allergy to the material used in the study;history of atopy;history of pathologies aggravated or triggered by ultraviolet radiation;intense sun exposure or tanning session up to 15 days before the initial assessment;expected intense sun exposure or tanning session during the study period;plan to take a swim in the sea, swimming pool or sauna during the study;participants who practice water sports;use of the following systemic topical medications:immunosuppressants,antihistamines,non-steroidal anti-inflammatory drugs,and corticosteroids up to two weeks before the selection;treatment with acid vitamin A and/or its derivatives orally or topically up to 1 month before the start of the study;anticipation of vaccination during the study or up to 3 weeks before the study,so as not to correlate the possible side effects of the vaccine with the study in question;any condition not mentioned above that,in the opinion of the investigator,may compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-9g3xrqk	Testing ways to make patients&apos; experience more comfortable after chest surgery	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7628	Measures to improve the experience of patients undergoing thoracic surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9g3xrqk	<NULL>	Patients aged 18 years or over; both genders; undergoing invasive thoracic procedures whether by thoracotomy, sternotomy or videothoracoscopy	Patients under 18 years of age; patients who do not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-7z76spy	Pilates method and virtual games: strategies to improve the quality of life of women with breast cancer treated by the SUS – randomized study	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7629	Pilates Method and Augmented Reality: strategies to improve the quality of life of users of the public health system diagnosed with Breast Cancer – randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7z76spy	<NULL>	Women; over 18 years old; SUS users; diagnosed with breast cancer undergoing treatment at the Advanced Center for Breast Diagnosis at Hospital das Clínicas de Goiânia	Clinical, orthopedic or neurological contraindications that prevent the practice of physical activity; less than 85% of the expected frequency of activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2rzx848	The Effects of Adding Pelvic Floor Muscle Exercises to Behavioral Therapy Associated with Transcutaneous Parasacral Nerve Electrical Stimulation on Sleep Quality in Women Who Are Awakened by Their Bladder to Urinate: A Randomized Controlled Clinical Trial	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7630	The effects of adding Pelvic Floor Muscle Training to Behavioral Therapy associated with Transcutaneous Parasacral Nerve Electrostimulation on Sleep Quality in women with Nocturia: a randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Faculdade de Educação Física e Fisiotrapia	Faculdade de Educação Física e Fisiotrapia	https://ensaiosclinicos.gov.br/rg/RBR-2rzx848	<NULL>	Women over 18 years of age; women with complaints of nocturia (being woken up by the bladder at least once a night, every night for the last 30 days); having Overactive Bladder Syndrome (OBS) who obtain a score ≥ 8 on the Overactive Bladder – Validated 8 (OAB-V8) questionnaire - an instrument for assessing overactive bladder and scoring very or very high on question 6 in the same questionnaire and who have a high risk of sleep apnea; the research participant must have had sexual intercourse for the pelvic muscle assessment to be carried out	Not knowing how to read and not being able to answer the questionnaires; having a urinary tract infection in the last two weeks; smoking; having undergone previous pelvic surgery with the exception of a cesarean section; having undergone previous pelvic radiotherapy; having a neurological disease; not undergoing pharmacological and physiotherapeutic treatment for Overactive Bladder Syndrome (OBS); having only Stress Urinary Incontinence (SUI); pelvic floor muscle strength 0 and 1 on the modified Oxford scale; being pregnant and up to 3 months postpartum; using medications that may affect nocturnal urination (antimuscarinics, diuretics); uncontrolled type 2 diabetes and heart disease; uncontrolled high blood pressure; low risk of sleep apnea; night and shift workers; not accepting to participate in the research and/or not signing the free and informed consent form (FICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-99xqr4t	Effects of ear Acupuncture on the Mental Health of nursing professionals in a cancer hospital	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7631	Effects of Chinese Auricular Acupuncture on Compassion Fatigue and Emotional Health of nursing professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-16	Hospital Universitário Júlio Müller	Secretaria do Estado de Saúde de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-99xqr4t	<NULL>	nursing professionals; of both sexes; aged 18 or over; with at least 6 months of practical experience; who work in sectors that provide direct patient care; who have answered all the questions in the questionnaires; who have time available to participate in the research stages; and who agree to participate in the research by signing the free and informed consent form	having a previously diagnosed severe psychiatric disorder and currently using psychotropic medications at the time of data collection; being pregnant; working exclusively in administrative functions (unit management and nursing coordination); using a hearing aid; presenting dermatological lesions; infection; inflammation; or injury in the auricular pavilion; or being allergic to adhesive tape on the auricle; or excessive oiliness in the ear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2kms8f9	Sleep disorders and their causes in children and adolescents in a city in northeastern Brazil	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7632	Sleep disorders and associated factors in children and adolescents in the metropolitan region of Recife	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2kms8f9	<NULL>	presence of headache for 3 months or more, of any origin and with intensity ≥ four on the Numeric Pain Intensity Scale.	presence of infection, inflammation or injury to the pinna; microporous tape allergy; prior energy therapy up to 3 months prior to the intervention; those undergoing physiotherapeutic treatment or making continuous use of medication for pain relief and pregnant women. In addition, it will be considered as a loss: refusal to receive auricular treatment, unavailability of time for TA sessions; missing two consecutive sessions and not showing up on the days scheduled for the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-78zfpxd	Comparative study between Local Freezing and back injection for Pain control after thoracic surgery	Not yet recruiting	Intervention	2025-01-03	<NULL>	<NULL>	7634	Cryoanalgesia versus thoracic epidural analgesia for Pain control in the postoperative period of thoracic surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78zfpxd	<NULL>	Patients of either gender; 18 years of age or older; undergoing invasive thoracic procedures, whether thoracotomy, sternotomy, or videothoracoscopy	Patients undergoing sympathectomy; patients undergoing procedures that do not access the pleural cavity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-107m2sgt	10 years of nutritional health records from the teaching clinics of the Brazilian Institute of Rehabilitation Medicine, Rio de Janeiro	Not yet recruiting	Observational	2025-01-06	<NULL>	<NULL>	7639	Retrospective analysis of 10 years of nutritional records in the teaching clinics of the IBMR University Center, Rio de Janeiro	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-10	Instituto Brasileiro de Medicina de Reabilitação	Instituto Brasileiro de Medicina de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-107m2sgt	<NULL>	Medical records of patients treated at the Teaching Clinics of the Brazilian Institute of Medicine and Rehabilitation (IBMR) University Center in Rio de Janeiro during the period from January 2014 to December 2024. Records must contain complete and up-to-date information on diagnoses, treatments, and clinical progress, with detailed documentation of nutrition-related health conditions, specifically hypertension, diabetes, obesity, malnutrition, and eating disorders. Records of patients treated at all units of the Teaching Clinics, regardless of gender, age, or ethnicity, provided they meet the other established criteria	Medical records with incomplete or illegible information, hindering the extraction and analysis of the data necessary for the research. Records of patients whose care occurred outside the period of interest, that is, before January 2014 or after December 2024. Records related to emergency or specific care that do not allow for a comprehensive analysis of nutrition-related health conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9hyxs47	Impact of Surgery to Reduce Lung Size on the ability to breathe, the ability to exercise, and the quality of life of people with advanced Chronic Obstructive Pulmonary Disease (COPD)	Not yet recruiting	Observational	2025-01-07	<NULL>	<NULL>	7643	Impact of Lung Volume Reduction Surgery on lung function, exercise capacity and quality of life in patients with severe COPD	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-10	Disciplina de Cirurgia Torácica Escola Paulista de Medicina - Universidade Federal de São Paulo	Disciplina de Cirurgia Torácica Escola Paulista de Medicina - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9hyxs47	<NULL>	Patients of both genders; between 18 and 80 years of age; with severe chronic obstructive pulmonary disease (COPD) (exacerbating profile or not); clinically stable	Patients with bullous disease that has been removed by bullectomy; patients in a severe clinical condition; patients on mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9f8qtqp	Effects of Posterior Crossbite Treatment in children with Aesthetic Aligners and Removable Appliances: a randomized clinical study	Not yet recruiting	Intervention	2025-01-09	<NULL>	<NULL>	7649	Effects of Posterior Crossbite Treatment in mixed dentition with Orthodontic Aligners and Conventional Appliances: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-9f8qtqp	<NULL>	Patients in mixed dentition; 7 to 10 years old; both genders; with Angle Class I malocclusion; erupted permanent upper and lower incisors; and unilateral or bilateral posterior crossbite	Patients with craniofacial deformities; absence of permanent teeth; presence of anterior open bite; and previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-3mj5vhs	Effects of resistance training with blood flow restriction on pain reduction, physical function improvement, and quality of life in patients with fibromyalgia	Not yet recruiting	Intervention	2025-01-13	<NULL>	<NULL>	7653	Effects of blood flow restriction strength training on clinical, functional markers, and quality of life in patients with fibromyalgia: a randomized, double-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Ciências da Saúde da Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3mj5vhs	<NULL>	Individuals diagnosed with fibromyalgia by a rheumatologist according to the American College of Rheumatology criteria (2010); female; Aged between 20 and 59 years; not engaged in strength training for at least 6 months; physically active; absence of cardiovascular, neurological, or psychiatric disease; ankle-Brachial Index (ABI) between 0.90 and 1.40, not indicating peripheral arterial disease; score above 3 on the visual analog scale	Undergoing any concomitant treatment during the study protocol, such as engaging in physical exercise, changes in medication treatment, and complementary therapies; minimum attendance of 80% in the training program; worsening of disease symptoms during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-2stdy4v	Effect of physical exercise on postural control and locomotor performance in people with hemophilia	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7657	Effect of physical exercise, functional capacity, postural control and kinematic analysis of locomotor performance during obstacle overcoming associated with gripping movement in people with hemophilia	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo - Campus Goiabeira	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-2stdy4v	<NULL>	Volunteers with Hemophilia A or B; Mild to Moderate or Severe Projects; male; body mass index less than 30	History of hip; knee; and ankle surgery; inability to walk with or without a device such as a cane or walker; history of bleeding into muscles or joints in the past 2 months; respiratory or neurological disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9krffvx	Comparison of Two Methods for Securing Subcutaneous Access and Their Effects on Comfort and Safety of Patients in Palliative Care	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7660	Effects of two Hypodermoclisis fixation techiniques on the occurrence of adverse event, length of stay and their implications for patient comfort in palliative care: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-9krffvx	<NULL>	patients of both sexes; from 18 years of age; with a medical prescription for hypodermoclysis; who do not have a diagnosis of skin changes; who do not have a known history of allergy to the tape used	Patients who develop an allergy to the tape used; are transferred to another unit will be discontinued from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-3q6jfwp	Comparative study of different therapeutic modalities for controlling postoperative pain in proximal femur surgery	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7661	Comparative study between pericapsular nerve block (PENG BLOCK) associated with the lateral femoral cutaneous nerve, iliac fascia block and intrathecal morphine in postoperative pain after proximal femur surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Secretaria Estadual de Saúde - RJ	Secretaria Estadual de Saúde - RJ	https://ensaiosclinicos.gov.br/rg/RBR-3q6jfwp	<NULL>	Participants over 18 years of age; of both sexes; undergoing surgery to correct a fracture of the proximal end of the femur	Allergy or intolerance to any of the drugs used in the study; liver failure; estimated glomerular filtration rate &lt; 15 mL/min/1.73 m2; known or suspected coagulopathy; pre-existing neurological or anatomical deficits in the lower extremities; cognitive impairment with difficulties in assessing pain and severe psychiatric illness; chemical dependency; history of mental illness; hemoglobin less than 9 mg/dl; conversion of spinal anesthesia to general anesthesia; blood transfusion; duration of surgery longer than 3 hours; change of surgical plan or orthopedic complication during surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-7w2yvfp	Direct Tracks to correct Unilateral Crossbite in children	Not yet recruiting	Intervention	2025-01-16	<NULL>	<NULL>	7666	Planas Direct Tracks (PDT) compared with no intervention for correction of Functional Posterior Crossbites in children: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-17	Associação Brasileira de Odontologia secção Bahia	Associação Brasileira de Odontologia secção Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7w2yvfp	<NULL>	Children between 4-5 years of age, both sexes; who have Posterior Crossbites Functional; and do not yet have the first permanent molar erupted; posterior unilateral crossbite defined as minimum two crossed posterior teeth; deviation of mandibular position from contact in centric occlusion to position of maximum intercuspation accompanied by line deviation average of at least 1mm; perimeter compatibility between the arches, that is, in position centric relationship, the maxilla should not exceed the mandible by more than 2mm; children who have eliminated finger-sucking and/or pacifier habits due to fur least 6 months until the exam date; children whose parents sign an informed consent form after the carrying out the exams	Children with cleft lip and/or palate; syndromes or neurological diseases associated with craniofacial anomalies or dental ankylosis; children with anterior crossbite or class III skeletal relationship; previous orthodontic treatment; caries or extensive restorations, with mesio-distal or disto-vestibular involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-96b5zp9	Clinical and laboratory evaluation of resin materials containing bioactive particles	Not yet recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7667	Clinical and in vitro performance of resin materials containing the bioactive particle S-PRG	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal do Paraná - UFPR	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-96b5zp9	<NULL>	Participants can be male or female; must be at least 18 and no more than 65 years old; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-8x8nmb4	Evaluation of the use of 2% tofacitinib in the treatment of non-pustular psoriasis on the hands and feet: a placebo-controlled clinical study	Not yet recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7669	Efficacy of 2% tofacitinib ointment in the treatment of non-pustular palmoplantar psoriasis: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual do Oeste no Paraná (UNIOESTE)	Universidade Estadual do Oeste no Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-8x8nmb4	<NULL>	Eligibility criteria for participation in the study include: adult individuals of both sexes; age between 18 and 60 years; clinical diagnosis of palmoplantar non-pustular psoriasis and active lesions at the time of inclusion; presence or history (documented by a dermatologist) of at least one additional plaque of psoriasis in another region of the body; a washout period of at least two weeks from the use of other topical medications that could affect psoriasis	The following participants will be excluded: patients with pustular psoriasis, erythrodermic psoriasis, or drug-induced psoriasis; evidence of other skin diseases that could affect the assessment of palmoplantar non-pustular psoriasis or the response to treatment; pregnant women; breastfeeding women; individuals with a known sensitivity to JAK inhibitors or to the vehicle/placebo; individuals using systemic JAK inhibitors; evidence of latent, active, or inadequately treated tuberculosis; hepatitis B or C infection; HIV (Human Immunodeficiency Virus) infection; history of disseminated or recurrent herpes zoster; history of infection requiring hospitalization or treatment with oral or topical antimicrobials within 2 weeks before baseline; history of lymphoproliferative disorders or malignancies (except for excised basal cell carcinoma or squamous cell carcinoma); history of thrombophilia; individuals using potent or moderate CYP3A4 inhibitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-3wn6k3p	Gastrointestinal issues caused by metformin use: what are the treatment alternatives?	Not yet recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7670	Occurrence of gastrointestinal adverse events and the use of metformin hydrochloride: are there other management options?	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-03-03	Universidade Federal de São João del-Rei	Universidade Federal de São João del-Rei	https://ensaiosclinicos.gov.br/rg/RBR-3wn6k3p	<NULL>	Male and female patients will be recruited. Age over 18 years. Patients using 500 mg immediate-release metformin hydrochloride for the first time	Pregnant women. Patients with a history of or declared allergies to folic acid. Those considered incapable of completing the adverse event perception form accurately: for the latter exclusion criterion, the patient&apos;s level of education and the presence or absence of a caregiver will be considered	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-2yd7sy5	Use of probiotics to help treat gingivitis	Not yet recruiting	Intervention	2025-01-23	<NULL>	<NULL>	7676	Use of probiotics as adjuvant in gingivitis treatment: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-20	Universidade Iguaçu	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-2yd7sy5	<NULL>	Healthy volunteers; non-smokers; of both genders; over 18 years of age; must present Gingivitis characterized by the presence of gingival bleeding in more than 10% of the sites evaluated	Cigarete smokers; history of previous periodontal treatment; antibiotics use within the past 6 months; pregnancy; presence of acute or necrotizing lesions; history of diabetes; rheumatic fever; neurological deficiencies; immunological diseases; use of medications that affect periodontal tissues such as phenytoin, cyclosporine, nifedipine and anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-8qcgzxw	Comparison between infiltration with Hyaluronic Acid and Corticosteroid in the joint in the treatment of chronic low back pain: clinical study	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7677	Comparative study between Hyaluronic Acid and Corticosteroids in facet joints in the treatment of chronic low back pain: randomized clinical study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital e Maternidade São Domingos	Hospital e Maternidade São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-8qcgzxw	<NULL>	Both genders; older than 18 years; with chronic low back pain for more than 3 months; with pain intensity greater than 4 on the visual analogue pain scale; no radicular pain; caused by degeneration of the facet joint and which presents relief after test block	Trauma patients; neurological deficits; infection at the puncture site; cognitive impairment; psychiatric illness; hypersensitivity to medications; use of anticoagulants; coagulopathy and pregnant women will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-9vsvkn5	Wheelchair mattress and cushion evaluation for pressure ulcer prevention	Not yet recruiting	Intervention	2025-01-25	<NULL>	<NULL>	7680	Evaluation of the C-CORE surface in the prevention of pressure injuries	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Escola de Enfermagem da Universidade Federal de Minas Gerais	Escola de Enfermagem da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9vsvkn5	<NULL>	Healthy adults; both genders; be over 18 years of age; have all limbs (upper and lower; be a non-smoker for at least one year; have the ability to move independently in bed and maintain supine and prone positions	Having a body height or width exceeding the size of the bed (2.0 x 0.85 m); presence of dermatological conditions involving scaling; skin wounds, or scars in areas of bony prominences (pressure measurement sites); or exhibiting pronounced spinal deformities upon inspection (lordosis or scoliosis)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-7dj4mt3	Counseling and Physical Exercises: effects on the Health of pregnant women during prenatal care	Not yet recruiting	Intervention	2025-01-25	<NULL>	<NULL>	7682	Impact of Counseling and Physical Exercises on biomarkers and health indicators of pregnant women in prenatal care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Jataí	Secretária Municipal de Saúde de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-7dj4mt3	<NULL>	Pregnant women registered at the basic unit and undergoing prenatal care; have completed 12 weeks of pregnancy; are aged 18 or over; live in the municipality of Jataí-GO	Pregnant women with clinical comorbidities (hypertension and diabetes); multiple pregnancies; pregnant women with intellectual disabilities identified by a health professional, reported by a companion, or perceived when answering the study instruments; having self-reported or perceived motor limitations that do not allow them to perform motor and functional tests and physical exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4p5mr8c	Study on the effectiveness and tolerance of nanotechnological products based on medicinal plants in ulcers of patients with diabetes	Not yet recruiting	Intervention	2025-01-27	<NULL>	<NULL>	7683	Study of the effectiveness and clinical tolerance of nanotechnological products from volatile oils of Salvia rosmarinus and Larix decidua in planter ulcers of diabetic people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital Universitário da Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4p5mr8c	<NULL>	Adult males or females. ≥ 18 years of age. Signed written informed consent. Diagnosis of type 1 or 2 diabetes mellitus. HbA1c ≤ 86 mmol/mol (≤ 10%) at screening. Subjects with at least first time with a full-thickness ulcer or recurrent ulcer (below the ankle) that fulfills all of the following criteria at screening and at the start of the protocol: A non-Interdigital wound. Accessible for administration of the products, tests, evaluations, and wound study procedures. Persistence of the wound for at least 6 weeks prior to the start of the protocol. Complete minimal skin ulcer without detachment, without muscle, tendon, or bone exposure. A wound area of 1.0 - 5.0 cm2 after cutting or mechanical debridement at screening. During the 2 weeks between the start of the initial phase and baseline, the wound size should not decrease by more than 30% or increase by more than 25%, which corresponds to wound areas of 0.7 - 6.3 cm2. Pressure on the tip of the foot ≥30 mm Hg. Diabetic patients who present neuropathic and/or ischemic ulcers without infection at any stage of healing. Willing to refrain from using unapproved lotions or creams on the site of injury and the surrounding area during the treatment period. Willing to refrain from washing the treated area for at least 8 hours after application of study medication. Laboratory values for the tests listed below within protocol-defined reference ranges, or &quot;out of range&quot; test results that are clinically acceptable for study participation. Ability to follow study instructions and likely complete all study requirements. Agree to participate in the research by signing the Informed Consent Form	Be under 18 years old. Pregnant or breastfeeding. Patients who do not fit into the ulcer classification stipulated for the study (severe injuries with deep infection, or with indication for amputation). Patients with cognition problems that make it difficult to apply treatment. Concomitant disease or treatment that suppresses the immune system. Chronic medical condition that, without the judgment of the investigator(s), would disrupt study performance or place the patient at undue risk. Known sensitivity to any of the components of the study medication. Treatment with systemic chemotherapy agents in the 6 months prior to selection. Use of systemic retinoids in the 6 months prior to the screening period. the leg presenting the planned or performed wound within 8 weeks prior to screening. Has any disease conditions, including ulcerative dermatologic disorders and vasculitis, or comorbidities that may preclude the subject from participating in the study or confound assessment of the safety profile and effect on wound healing. Female subjects of childbearing potential unless using a contraceptive method with a failure rate &lt; 1% to prevent pregnancy. Patients who do not have continuous monitoring by their family or caregiver and those who cannot attend within the specified period for evaluation and dressing changes (lost to follow-up)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4zhxxhd	Longitudinal analysis of children and adolescents with radiographic bone alterations in the milk tooth phase treated at the Piracicaba Dental School	Not yet recruiting	Observational	2025-01-28	<NULL>	<NULL>	7688	Longitudinal analysis of children and adolescents with radiographic bone alterations in deciduous dentition treated at the Piracicaba Dental School	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-02	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4zhxxhd	<NULL>	"Individuals treated at the Piracicaba Dental School identified with a radiographic distance between the alveolar bone crest and the cementoenamel junction greater than 2 mm and parents and biological siblings;age from 5 years;any gender

Controls: Individuals treated at the Piracicaba Dental School identified with a radiographic distance between the alveolar bone crest and the cementoenamel junction equal to or less than 2 mm, and close relatives (parents and biological siblings)."	Motor impairments that hinder oral hygiene;use of fixed orthodontic appliances;continuous use of anti-inflammatory and or systemic antimicrobial medications in the past 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-9fnhzqw	Effects of Physical Exercise on Patients Treated with Drugs for Breast Cancer	Not yet recruiting	Intervention	2025-01-28	<NULL>	<NULL>	7689	Effects of Physical Exercise during Chemotherapy in Patients with Breast Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-02	Bruno Gama Linhares	Faculdade de Medicina de Campos - Fundação Benedito Pereira Nunes	https://ensaiosclinicos.gov.br/rg/RBR-9fnhzqw	<NULL>	Women over 18; histological diagnosis of stage IA-IIIC breast carcinoma; scheduled to receive chemotherapy with anthracyclines or trastuzumab; be able to understand and accept informed consent; breast cancer patients	Contraindications for exercise testing, decompensated comorbidities; pre-existing heart disease, pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-96bp2pb	Clinical trial phase 1/2 to verify the safety of oral clarified açaí extract in acute ischemic stroke	Not yet recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7697	Randomized and controlled clinical trial, single-center phase 1/2, to verify the safety of oral clarified açaí extract in acute ischemic stroke (AÇA-ICTUS study)	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-02-01	Instituto de Ciências da Saúde da Universidade Federal do Pará	Hospital da Aeronáutica de Belém	https://ensaiosclinicos.gov.br/rg/RBR-96bp2pb	<NULL>	Age 18 years or older; diagnosis of ischemic stroke on admission; absence of bleeding on admission cranial tomography; National Institute of Health Stroke Scale equal or higher than 5 on admission; possibility of administering treatment within 24 hours from the onset of symptoms	Previous moderate functional disability (modified Rankin Scale equal or higher than 3); indication of thrombolytic therapy (chemical, mechanical); inability to tolerate or accept study procedures; co-occurrence of other serious clinical emergencies/urgencies on admission (e.g., cardiopulmonary arrest, acute respiratory failure, septic shock, status epilepticus, signs of intracranial hypertension); National Institute of Health Stroke Scale equal or higher than 20 on admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-7jw7z2g	Platelet-rich blood product or corticosteroid, which is better for treating partial shoulder injuries?	Not yet recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7701	I-PRF vs Corticosteroid in the Treatment of Tendinopathy and Partial Tears (&lt;50%) of the Supraspinatus Muscle: double-blind clinical trials	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jw7z2g	<NULL>	Age between 18 and 65 years old; Shoulder pain and/or lateral deltoid; At least 3 months of symptoms; Physical examination with positive JOBE test, no pain in the acromioclavicular joint and no symptoms of instability; Tendinopathy/partial injury (less than 50%) of the supraspinatus muscle tendon confirmed by magnetic resonance imaging (MRI); no prior surgical intervention; agreement with the Free and Informed Consent Form (TCLE)	Body mass index greater than 18 and less than 35 kg/m2; pregnancy or lactation; systemic diseases (DM – glycated hemoglobin greater than 6.5); hematological disease (anemia, coagulopathy, thrombophilia); hemoglobin less than 11g/dL; Hematocrit less than 33%; Platelets less than150,000/µL; presence of another disease that could cause pain and dysfunction in the shoulder, such as arthritis or bone injury; such as arthritis or bone damage; ipsilateral limb orthopedic disease; rheumatological disease; chronic kidney disease on dialysis. Respiratory pathology (Rhinitis, Asthma, Chronic obstructive pulmonary disease); oncological disease; fibromyalgia or psychiatric pathology under treatment; chemical dependency (smoking, alcoholism, others); use of non-steroidal anti-inflammatory drugs in the last 30 days; use of glucocorticoids in the last 3 months (systemic, articular, topical, inhaled); Use of anticoagulants or antiplatelet agents; Anesthetic risk: ASA greater than or equal 3; patients receiving social security benefits (sickness benefit); limitation of range of motion compared to the contralateral side; partial injury, such as fissure, partial, fissure-type injury, partial rupture less than 50% or total of the supraspinatus tendon proven by magnetic resonance imaging; presence of acromion hooked seen on MRI; patients unwilling or unable to provide Free and Informed Consent Form (TCLE)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-35y8dwr	Assessment of skin, vagina and penis acceptability with perceived efficacy	Not yet recruiting	Intervention	2025-02-04	<NULL>	<NULL>	7704	Orc_135676_en24-0630-01_assessment of dermal, urological and gynecological acceptability with perceived efficacy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-20	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-35y8dwr	<NULL>	For the female audience: female participants aged 18 to 65 years; sexually active; with vaginal dryness; heterosexual couples in a stable union or civil marriage; intact skin on the vaginal mucosa; user of products of the same category; agreement to follow the trial procedures and attend the Clinical Research Center on the days and times determined for evaluations; understanding, consenting to and signing the Free and Informed Consent Form; for the male audience: male participants aged 18 to 65 years; sexually active; heterosexual couples in a stable union or civil marriage; intact skin on the penile region; user of products of the same category; agreement to follow the trial procedures and attend the Clinical Research Center on the days and times determined for evaluations; understanding, consenting to and signing the free and informed consent form	Pregnancy or risk of pregnancy and/or lactation (for women); participants with erectile dysfunction (for men); sexually transmitted infections, such as: candidiasis, trichomoniasis, gonorrhea, chlamydia or pathologies that compromise the evaluation of the safety of use of the product; use of anti-inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevi, sunburn); atopic or allergic history of products in the same category; active skin pathologies and/or lesions (local and/or disseminated) in the evaluation area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the evaluation; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; other conditions considered by the researcher as reasonable for disqualification from participation in the study. If so, it should be described in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-5rf37wv	The Effect of a Protein Restricted Diet on Markers of Renal Function in Patients with Long-Term Renal Impairment Who are Undergoing Conservative Treatment	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7707	Effect of Low-Protein Diet on Renal Function Markers in Conservatively Treated Patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-05	Hospital Universitário Lauro Wanderley da Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5rf37wv	<NULL>	Adult patients 18 years of age and older treated at the Nephrology Outpatient Clinic of the Lauro Wanderley University Hospital; Chronic Kidney Disease stage 3B to 5 not on dialysis; Glomerular filtration rate between 14-60 mL/minute; Male and female	Patients with chronic kidney disease due to autoimmune disease; Transplant recipients; Polycystic kidney disease; Renal neoplasia or single kidney disease; Liver Disease; Human Immunodeficiency Virus Carriers; Smokers; Pregnant women; Patients using dietary supplements such as probiotics, prebiotics, symbiotics, and antioxidants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4cfz6sp	Clinical Evaluation of Composite Resins Tetric N-PowerFill 2 vs. Tetric NCeram 2 in Deciduous Molars: A Clinical Study	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7708	Clinical Evaluation of Tetric N-PowerFill 2 vs. Tetric N-Ceram 2 in primary posterior teeth: A prospective, randomized, double-blinded parallel study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4cfz6sp	<NULL>	Good general and oral health; no need for endodontic or periodontal treatment; patients between three and ten years old who require a restoration in a primary posterior tooth; any gender	Severe systemic diseases; poor oral hygiene; allergy to any components present in the materials used; patients with a high risk of pulp exposure; endodontic complications; chronic use of medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-722dg2y	Evaluation of the treatment of Uterine Endometriosis with three types of hormones: Dienogest pill, Etonogestrel implant and System releasing Levonorgestrel	Not yet recruiting	Intervention	2025-02-06	<NULL>	<NULL>	7722	Evaluation of the treatment of Adenomyosis with Dienogest, Etonogestrel Implant and Intrauterine System releasing Levonorgestrel – randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-722dg2y	<NULL>	Women; age between 18 and 45 years old; diagnosis of adenomyosis, both by magnetic resonance imaging and transvaginal ultrasound; have agreed to participate in the study and signed the Free and informed consent form	Women with uterine fibroids, endometrial polyps and other structural causes of abnormal uterine bleeding; women with cardiovascular, hepatic, renal failure or any other contraindications for the use of progestogens or the intrauterine system; women not having initiated sexual activity; women who cannot read or have some cognitive deficit that prevents them from understanding the questionnaires and the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-485qvzm	Using light therapy to help treat Sickle Cell Anemia	Not yet recruiting	Intervention	2025-02-08	<NULL>	<NULL>	7726	Photobiomodulation Terapy: a novel approach to support the treatment of Sickle Cell Anemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-485qvzm	<NULL>	Have a diagnosis of sickle cell anemia; be 12 years old; both sexes; the weight of these individuals must be equal to or greater than 40 kg; must be treated at the Hospital Foundation of Hematology and Hemotherapy of Amazonas	Individuals with a diagnosis of coagulation factor disorders; frequent and recent hemorrhagic episodes; glaucoma; pregnancy; the presence of malignant tumors or benign tumors with the potential to become malignant; active sepsis; chest trauma; history of tracheostomy; autoimmune disease; conditions of light sensitivity or use of photosensitive drugs; neurodegenerative diseases, and terminal illnesses will not be admitted to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-99z7jnq	Effect of Ketamine combined with conventional treatment in Treatment-Resistant Depression and Suicide Risk	Not yet recruiting	Intervention	2025-02-10	<NULL>	<NULL>	7730	Effectiveness of Ketamine as an adjuvant to Lithium Carbonate and standard pharmacological treatment in adults with treatment-resistant unipolar and bipolar depression and the risk of suicide with intent: a double-blind study	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2025-02-15	Hospital Universitário Walter Cantídio Universidade Federal do Ceará	Hospital Universitário Walter Cantídio Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-99z7jnq	<NULL>	Participants of either sex; aged between eighteen and sixty-five years; body weight of fifty kilograms to one hundred twenty kilograms; informed consent obtained prior to participation; effective contraceptive methods for sexually active heterosexual women of childbearing potential (blood or urine test requested during screening, on medication administration days, and in case of clinical doubt about pregnancy status during the observation period); clinical stability demonstrated by physical examination, medical history, vital signs, and twelve-lead electrocardiogram during screening; abnormalities allowed if deemed clinically insignificant by the principal investigator and documented in source records; agreement to receive standard pharmacological treatment for treatment-resistant depression, treatment-resistant bipolar depression, and/or suicidal risk, as assessed by the responsible physicians; treatment-resistant depression: current major depressive episode without psychotic features, confirmed by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version, Montgomery-Åsberg Depression Rating Scale score of eighteen or higher, resistance to two or more antidepressants and/or adjunctive agents; treatment-resistant bipolar depression: current major depressive episode without psychotic features, confirmed by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version, diagnosis of bipolar disorder type I or II according to DSM-5 criteria, absence of sustained symptomatic remission for at least eight weeks or intolerance to two different treatments; suicidal risk with Montgomery-Åsberg Depression Rating Scale score of twenty-eight or higher, current suicidal ideation with intention confirmed by the Columbia-Suicide Severity Rating Scale and Montgomery-Åsberg Depression Rating Scale item 10 score ≥ 4	Manic episode limited to groups with treatment-resistant depression or suicidal intent; major depressive episode with psychotic features; schizophrenia or schizoaffective disorder as determined by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version; alcohol or substance use disorder, excluding tobacco, or withdrawal symptoms requiring detoxification; inpatient or outpatient detoxification treatment within six months prior to screening; suicidal ideation or behavior primarily due to a condition other than major depressive disorder; current clinical diagnosis of autism spectrum disorder, neurocognitive disorders, or intellectual disability; history of seizures, except for childhood febrile seizures; malnutrition; inability to provide informed consent or comply with study requirements; pregnancy, lactation, or intention to become pregnant within the next twelve weeks; active infection with hepatitis B virus, hepatitis C virus, human immunodeficiency virus, or COVID-19; history of traumatic brain injury within the last six months; history of hypersensitivity to the study medications or their excipients; use of monoamine oxidase inhibitors within fourteen days before screening; cardiac disease or abnormal cardiac repolarization, including a history of myocardial infarction, angina pectoris, or coronary artery revascularization within six months prior to the start of the study treatment; history of clinically significant cardiac arrhythmias, complete left bundle branch block, advanced atrioventricular block, including bifascicular block, Mobitz type two, or third-degree atrioventricular block within six months prior to the start of the study treatment; Fridericia-corrected QT interval (electrocardiographic trace measured from the beginning of the QRS complex to the end of the T wave) at rest of greater than or equal to four hundred fifty milliseconds for men or greater than or equal to four hundred sixty milliseconds for women at screening or prior to the first dose on day one; inability to determine the Fridericia-corrected QT interval (electrocardiographic trace measured from the beginning of the QRS complex to the end of the T wave); risk factors for Torsades de Pointes, including uncorrected hypokalemia or hypomagnesemia, history of heart failure, or history of clinically significant or symptomatic bradycardia, long QT syndrome, family history of sudden unexplained death or congenital long QT syndrome; concomitant medication with a known risk of Torsades de Pointes that cannot be discontinued or replaced with a safe alternative medication seven days before screening and throughout the double-blind phase; average systolic blood pressure greater than one hundred forty millimeters of mercury or diastolic blood pressure greater than ninety millimeters of mercury at screening and before the first dose of medication on day one; elevated blood pressure or intracranial pressure that poses a serious risk, including vascular disease such as aneurysm and a history of intracerebral hemorrhage; any other condition, including liver disease or malignancy, that, according to the principal investigator&apos;s assessment, compromises the participant&apos;s safety; evidence of significant renal impairment indicated by an estimated glomerular filtration rate of less than forty milliliters per minute per one point seventy-three square meters at screening; use of other investigational medications within thirty days before screening; women of childbearing potential unless using highly effective contraceptive methods during the study treatment and for one week after discontinuation of the medication; effective contraceptive methods include total abstinence when consistent with the participant&apos;s preferred and usual lifestyle; bilateral oophorectomy with or without hysterectomy, total hysterectomy, or tubal ligation at least six weeks before administration of the investigational medication; male sterilization at least six months before screening; use of intrauterine device or intrauterine system; oral contraceptive or systemic hormonal contraception, including transdermal or implanted hormonal methods; women considered postmenopausal and not fertile if they have experienced twelve months of natural amenorrhea with a clinically appropriate profile, history of age-appropriate vasomotor symptoms, bilateral oophorectomy with or without hysterectomy, total hysterectomy, or tubal ligation for at least six weeks; absence of previous clinical exams or assessments that may confirm the absence of the aforementioned conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-7x8bkv2	Evaluation of how Cryotherapy aids athlete recovery after intense CrossFit workouts	Not yet recruiting	Intervention	2025-02-11	<NULL>	<NULL>	7733	Evaluation of the effects of Cryotherapy on the recovery of delayed onset Muscle Soreness in athletes after high-intensity interval training in WOD Murphy in CrossFit: a controlled, randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7x8bkv2	<NULL>	Participants must be between 18 and 45 years old. Of either sex. They must have at least six months of regular CrossFit experience, training a minimum of three times per week. It is essential that athletes are considered healthy and do not have any current or chronic musculoskeletal injuries that could interfere with the execution of the Murph WOD or the application of cryotherapy. Participants must not have performed the Murph WOD or similar high-intensity exercises in the four weeks prior to the start of the study. All participants must provide written informed consent, indicating that they understand the study procedures, risks, and benefits. Additionally, they must be available for training sessions, cryotherapy application, and subsequent assessments within the timeframe established by the study. Athletes&apos; body mass index (BMI) must be between 18.5 and 30 kg/m². Participants must not have used cryotherapy regularly as a recovery method in the three months preceding the study. It is important that athletes demonstrate the ability to follow study instructions and protocols consistently and correctly. Participants must be able to read and comprehend the language in which the study and informed consent are presented, ensuring they fully understand all instructions and study requirements	Participants who present any medical condition that may be exacerbated by intense exercise or exposure to cold, such as severe cardiovascular, respiratory, or metabolic diseases, will be excluded. Athletes with a history of chronic or recent musculoskeletal injuries that may interfere with the execution of the Murph WOD or the application of cryotherapy will also be excluded. Individuals who have performed the Murph WOD or similar high-intensity exercises in the four weeks prior to the start of the study will not be eligible. Participants who have regularly used cryotherapy as a recovery method in the three months preceding the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-29x9zbc	Effects of bandaging on pain and abdominal muscle separation in postpartum women: a randomized controlled trial	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7735	Effects of Kinesio Taping on pain and diastasis of the rectus abdominis muscles in postpartum women: a randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-17	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-29x9zbc	<NULL>	Postpartum women; normal-risk pregnancy; single fetus; age between 18 and 40 years; up to 72 hours postpartum; via vaginal delivery or cesarean section; full-term birth between 37 and 42 weeks; no abdominal surgeries in the last 12 months	Obstetric complications; postpartum hemorrhage; postpartum depression; infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3q7szpv	Effects of Teleconsultation for the care of children with feeding difficulties	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7738	Effects of a Teleconsultation program on the quality of care for parents and caregivers of children with Dysphagia: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3q7szpv	<NULL>	Third, a non-progressive neurogenic disorder medical diagnosis, and a neurogenic dysphagia clinical diagnosis; Ser pacientes attended no ambulatório Gastropedriatria do Hospital das Clínicas da Universidade Federal de Pernambuco; Fazer parte dos casos identificados no ano de 2024 no respectiveo serviço; Aceitar participar da teleconsulta e do estudo.	First consultation; Do not accept consultation via video call.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-22bjcq6	Comparison of Mat Pilates versus Equipment-based Pilates for treating knee Osteoarthritis	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7743	Comparison between Mat Pilates and Equipment Pilates in the Treatment of Patients with Knee Osteoarthritis: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-20	Departamento de Fisioterapia da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-22bjcq6	<NULL>	Individuals of both sexes. Aged between 50 and 80 years. Presence of chronic-degenerative joint impairment in the knee for more than 12 weeks. Sedentary individuals diagnosed with unilateral or bilateral knee osteoarthritis. Confirmed diagnosis of knee osteoarthritis according to the criteria of the American College of Rheumatology presence of knee pain and at least one of the following criteria age equal to or greater than 50 years, crepitus during knee movements, increased sensitivity to compression, reduced local warmth, bone enlargement, and morning stiffness lasting less than 30 minutes. Grade 2 or higher osteoarthritis according to the Kellgren and Lawrence classification. Presence of pain with a score equal to or greater than 3 on the Numeric Pain Scale. Use of the Physical Activity Readiness Questionnaire to assess the need for medical evaluation before physical activity practice	Asymptomatic knee osteoarthritis. History of previous surgery on the lower limbs. Diagnosis of neurological inflammatory rheumatic infectious or traumatic disorders. Severe visual impairments. Use of prosthetics in the lower limbs. Inability to understand Portuguese. Body Mass Index above 40. Physical therapy treatment performed in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-29mvy54	Clinical study on the effect of Microfocused Ultrasound on facial rejuvenation	Not yet recruiting	Intervention	2025-02-13	<NULL>	<NULL>	7745	Clinical study on the efficacy and safety of Microfocused Ultrasound for Facial Rejuvenation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-02	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-29mvy54	<NULL>	Patients aged between 35 and 65 years; patients who show moderate signs of skin aging; both sexes	Patients with a history of photosensitivity will be excluded; tendency to form keloids; with dermatitis; active herpes infection at the procedure site; pregnant women; breastfeeding women; pacemaker holders; with decompensated chronic diseases; wearing metal prostheses in the area to be treated; with a history of heart disease; patients with a history of autoimmune diseases using isotretinoin; anticoagulants; with a history of previous aesthetic treatments in the area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3xtpk68	Study on the effects of Acupuncture on endometrial characteristics in embryo transfer preparation cycles	Not yet recruiting	Intervention	2025-02-13	<NULL>	<NULL>	7746	Effect of Acupuncture on Endometrial Characteristics in Cycles and Preparation for Embryo Transfer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3xtpk68	<NULL>	Women of childbearing age; between 18 and 44 years old, and that the collection of their eggs must be carried out until the age of 41; who have already undergone in vitro fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI) and have had implantation failure; who have frozen embryos and wish to transfer them; who agree to participate in the research after reading and signing the informed consent form	Daily use of medications (anti-inflammatories and muscle relaxants); women undergoing treatments for psychiatric illnesses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3gc2sqb	Effects of a mindfulness-based intervention on nurse leaders&apos; emotional intelligence, self-compassion and resilience	Not yet recruiting	Intervention	2025-02-14	<NULL>	<NULL>	7747	Effects of a mindfulness-based intervention on nurse leaders&apos; emotional intelligence, self-compassion and resilience: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3gc2sqb	<NULL>	Volunteer nurse leaders, hired by the São Paulo Hospital and Outpatient Clinics, Prof. Dr. Waldemar de Carvalho Pinto General Hospital of Guarulhos, State Hospital of Diadema Governador Orestes Quercia, General Hospital of Pedreira, and Municipal Hospital of Barueri Dr. Francisco Moran, São Paulo, Brazil; be 18 years of age or older; both sexes	Be a daily practitioner of any type of practice that uses mindfulness (such as: Yoga, Tai Chi Chuan, Chi Kung, among others), as indicated by the Sociodemographic and Clinical Questionnaire (QSDC); participants with a diagnosis and/or treatment for psychosis or schizophrenia, as indicated by the QSDC; participants who present suicidal ideation or severe depression, as scored by the Patient Health Questionnaire-9 (PHQ-9), 20 points or more for cutoff; participants who have problems with alcohol and drug abuse, as verified by the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) questionnaire, 26 points or more for cutoff	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-9d29wpj	Effect of yerba mate extract consumption on anthropometric parameters, body composition, and blood markers of inflammation, glycemic profile, and lipid profile in overweight individuals	Not yet recruiting	Intervention	2025-02-14	<NULL>	<NULL>	7748	Yerba mate extract (Ilex paraguarensis): effect of ingestion on anthropometric parameters, body composition, inflammatory markers, glycemic profile, and lipid profile in overweight individuals: a randomized, placebo-controlled, crossover, and triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-9d29wpj	<NULL>	Individuals over the age of 18; Body Mass Index (BMI) greater than or equal to 24.99 kg/m²; both sexes	Individuals with a Body Mass Index (BMI) greater than or equal to 24.99 kg/m²; significant weight variation (more than 10%) in the last 3 months; use of anti-inflammatory medications; pregnancy or breastfeeding; allergies or hypersensitivity to any of the ingredients of the interventions; smoking; alcoholism; intense physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-7mpnx6t	Assessment of heart health and metabolism in Menopausal women using Isoflavones: a control group study	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7751	Cardiovascular evaluation and metabolic profile of women in Menopause using Daidzein and Genistein: a placebo-controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Fundacao Universidade de Pernambuco	Fundacao Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7mpnx6t	<NULL>	60 female volunteers; age between 49 and 52 years old; in menopause after one year of the last menstrual period	Patients with cardiorespiratory disorders; neurological; and other known impairments that prevent the subject from carrying out the procedures; do not drink alcoholic beverages; nor consume substances containing isoflavones such as green tea, peas, peanuts, chickpeas, lima beans, broad beans, lentils and flaxseeds; or carry out high-intensity training for 24 hours prior to the assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-47274gx	Effect of strength training combined with physiotherapeutic exercises on muscle recovery and rehabilitation in athletes and active adults: an evaluation of the heart, muscle, and blood: a randomized placebo-controlled trial	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7754	Effect of strength training combined with different therapeutic modalities on musculoskeletal mecovery and rehabilitation in athletes and recreationally active adults: an integrated approach to cardiovascular, autonomic, neuromuscular, and blood responses: a randomized placebo-controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-47274gx	<NULL>	Perform at least 300 minutes of physical activity per week. Be between 18 and 59 years old. Both sexes. Be free from functional limitations that prevent the tests and/or the proposed protocol from being performed.	Consuming caffeine-based ergogenic aids. Reporting any type of acute dizziness. Presenting abnormal fluid accumulation (edema), especially in the lower limbs. Presenting impairments in the basilar artery that make cervical manipulations impossible. Diagnoses that affect postural control, such as vestibular dysfunction, Alzheimer&apos;s disease, Parkinson&apos;s disease, or motor neuron disorders. History of lower limb trauma in the last year. Presence of severe cardiopulmonary disease. Participants currently involved in a structured exercise program focused on postural control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-67fdcbg	Effects of Neurostimulation in children with speech and language difficulties	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7756	Transcranial Direct Current Stimulation in cognitive and language skills	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal de Sergipe	Programa de Pós-graduação em ciências aplicadas à Saúde (PPGCAS)	https://ensaiosclinicos.gov.br/rg/RBR-67fdcbg	<NULL>	Children of any sex; have a diagnosis of speech and language disorders; aged between 6 and 12 years old; inserted in the regular school environment; have degrees of understanding and collaboration compatible with carrying out the proposed intervention, that is, accept the placement of electrodes and the time required for stimulation	Children whose guardians, at some point during the research, withdraw their free and informed consent; children with epilepsy; who use metallic brain implants or hearing aids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6sff9qt	Postoperative nausea and vomiting in Brazil	Not yet recruiting	Observational	2025-02-17	<NULL>	<NULL>	7757	Survey on the use of antiemetics for the prophylaxis of postoperative nausea and vomiting in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-28	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-6sff9qt	<NULL>	Anesthesiologists and physicians specializing in Anesthesiology of the Brazilian Society of Anesthesiology. Who are duly registered and actively enrolled in the company. That they are in accordance with the Informed Consent Form and the research instruments. Both sexes	Anesthetists not registered on the Brazilian Society of Anesthesia website	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6ffgn7t	Efficacy of Zinc Acetate mouthwash in controlling Bad Breath - A clinical study	Not yet recruiting	Intervention	2025-02-18	<NULL>	<NULL>	7764	Efficacy of Zinc Acetate mouthwash in controlling Halitosis - Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-13	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-6ffgn7t	<NULL>	Participants of both sexes; aged over 18 years; students in the health area of ​​the Federal University of Piauí, Teresina, Brazil, diagnosed with halitosis by the organoleptic method at levels 2, 3, 4 or 5 on the Schmidt scale; who have at least 15 teeth in the mouth and do not use removable dentures	Individuals with a history of allergic reactions to the components of the tested solution; who have used mouthwash of any type in the last two days before the exam; who have consumed alcoholic beverages in the last 24 hours before the exam and who are conventional or electronic smokers will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-63q9z47	Clinical evaluation of restorations located close to the gums using universal adhesives	Not yet recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7765	Interaction of universal dentin bonding systems of non carious cervical lesions: a randomized clinical controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Clinica Multidisciplinar	https://ensaiosclinicos.gov.br/rg/RBR-63q9z47	<NULL>	Patients of any gender; at least 18 years old; good general health; acceptable oral hygiene; presence of at least 20 teeth in occlusion; two or more teeth (in occlusion, vital and without mobility) with similar cervical lesions predominantly caused by Erosive Tooth Wear and with a supragingival margin	Caries activity; systemic health complications; active or chronic periodontal disease; severe bruxism or other parafunctional habits; patients using a complete denture or implants occluding with the teeth of interest; patients who have undergone orthodontic, hypersensitivity or whitening treatment in the last 6 months; pregnant or breastfeeding women; allergies to the main components of the products used in this study; unavailability of time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-26x4qtw	Effects of peripheral ischemia on clinical recovery in patients with stroke	Not yet recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7766	Effects of ischemic post-conditioning on clinical recovery in patients with stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital Universitário da Universidade Estadual de Ponta Grossa	Grupo de Estudo sobre Respostas e Adaptações Fisiológicas ao Exercício da Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-26x4qtw	<NULL>	Both-gender patients; diagnosed with Ischemic Stroke with infarction of large arteries or small arteries; aged between 45 and 65 years; with clinical stability; independence prior to the event; degree of acute Ischemic Stroke at the time of hospital admission between 5 and 20 on the National Institutes of Health Stroke Scale will be included	Patients with infarctions of cardioembolic origin; patients whose investigation does not define the site of infarction; with previous Stroke; with systolic blood pressure above 200 mmHg; with ulcerative lesions in the lower limbs; patients who, after thrombolytic therapy, present lower than 5 points on the National Institutes of Health Stroke Scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6k6344n	Evaluation of toothpastes to treat Tooth Sensitivity in patients undergoing Home Whitening teeth treatment	Not yet recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7770	Evaluation of desensitizing toothfrices with obliterating and neural action in reducing Tooth Sensitivity during Home Whitening with Hydrogen Peroxide	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-05	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6k6344n	<NULL>	Patients with initial color selection equal to or below A2, B2 or C2; patient with periodontal health condition; patient aged 18 to 50 years; patients of both sexes; patient with central, lateral and canine incisors present in the mouth	Patient who did not sign the free and informed consent form;  patients with initial color selection equal to or above A1, B1 or C1; patient with active periodontal disease; patient with a history of sensitivity; patient with direct and/or indirect anterior restorations involving the buccal surface; patients with fixed prostheses on more than 2 anterior teeth; patients who already use continuous desensitizing toothpaste; patients who have already had whitening in the last 5 years; patients with chronic use of anti-inflammatory or analgesic medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-78bn3gf	Effect of Strength Training and Miconia Albicans on Pain, Inflammation and Functionality in women with knee Osteoarthritis	Not yet recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7772	Effect of Resistance Training and Miconia Albicans on Pain, Inflammation and Functionality in women with knee Osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-78bn3gf	<NULL>	Female subjects with radiographs showing knee osteoarthritis grades II and III on the Kellgren and Lawrence osteoarthritis classification. Knee pain greater than 3 on the numerical pain rating scale. Age 50 to 70 years and functional impairment in the past 3 months that met at least one of the American College of Rheumatology classification criteria	Female individuals with neurological, cardiovascular and/or pulmonary diseases that may compromise the execution of the exercise protocol. Have used intra-articular injections of steroids or other substances in the last three months. Have systemic inflammatory disease. Have had orthopedic surgery on the lower limbs or are unable to perform the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-7c7zh75	Comparison between regional techniques and spinal anesthesia associated with general anesthesia for laparoscopic gynecological surgeries - a randomized study	Not yet recruiting	Intervention	2024-12-02	<NULL>	<NULL>	7780	General Anesthesia combined with regional techniques in Laparoscopic Gynecological Surgeries, comparison between Tap Block, Quadratus Lumbar Block and Spinal Anesthesia with Opioid: randomized study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-05-04	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-7c7zh75	<NULL>	Patients aged 18 to 65 years; female; American Society of Anesthesiologists physical status - ASA I or II; undergoing total laparoscopic hysterectomy	Patients with severe comorbidity (American Society of Anesthesiologists physical status - ASA III or higher); cardiac arrhythmias; dilated cardiomyopathy; cardiac conduction disorder; electrolyte disorder; acid-base disorder; hypersensitivity to lidocaine; psychiatric, hepatic, respiratory or oncological diseases; patients who were receiving any type of analgesic in the week prior to surgery; patients who received blood products during the study period; and those whose health insurance does not cover the intervention procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-8csbc2g	Personalized Nutrition in the care of people with Obesity: genetic risk and personalized guidance in controlling hunger and appetite	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7798	Precision Nutrition in the care of people with Obesity: (epi)genetic scores and personalized guidance in controlling appetite and satiety	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8csbc2g	<NULL>	Men and women will be included; between 20 and 55 years old; overweight; high waist circumference; excess body fat associated with at least one of the other components of Metabolic Syndrome; obesity and excess body fat independent of the presence of the other components of Metabolic Syndrome	Pregnant women; lactating women; women in menopause; athletes; shift workers; people with physical and/or intellectual disabilities; intolerance or food allergies to the test foods; type 1 diabetes mellitus; autoimmune diseases or use of immunosuppressants; hormonal disease; digestive disease or alterations; carriers of inflammatory bowel or liver diseases; chronic kidney disease; pancreatitis; cardiovascular diseases; eating disorders; cancer; infectious episode in the last month; history of illicit drug use and/or alcohol consumption greater than 21 and greater than 14 units/week for men and women, respectively; having undergone bariatric surgery; indicating weight instability (5% of usual weight) in the last three months; habitual consumption of granola, nuts, whole grains or seeds (sesame, pumpkin and sunflowerseeds, flaxseed) &gt;30 g/day; following a vegan, vegetarian or dietary restriction diet (gluten, lactose); use of anti-inflammatory drugs, corticosteroids, antipsychotics, antidepressants that may affect appetite and energy metabolism; use of vitamin, mineral and omega-3 supplements; use of fiber supplements (psyllium, inulin); not having participated in nutritional interventions in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-7dn5w43	Evaluation of the effects of Sedation with Midazolam and Nitrous Oxide versus Physical Restraint in children with Intellectual Disabilities during dental treatments	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7800	Randomized clinical trial of the effects of Sedation with Midazolam associated with Nitrous Oxide compared to Protective Stabilization during dental care for children with Intellectual Disabilities	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal do Rio de Janeiro	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7dn5w43	<NULL>	Children of both genders; with a physical status classification from I to III, as defined by the American Society of Anesthesiologists; aged between 3 and 12 years; prior diagnosis of intellectual disability confirmed by caregivers; behavior classified as negative or definitely negative on the Frankl scale during screening at the Clinic for Children with Disabilities of the Department of Pediatric Dentistry at the Faculty of Dentistry of the Federal University of Rio de Janeiro, indicating the need for protective stabilization to perform dental treatment; need for dental treatment identified during screening, including restoration, pulpal therapy, or simple extraction	Children weighing less than 15 kg; airway classification by the modified Mallampati scale equal to or greater than III; medical contraindication for intranasal medication sedation, inhalation sedation, or protective stabilization; presence of disabilities without intellectual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-2q5dg2d	Treatment of Dental Hypersensitivity with Low-power Laser and Resin Film: a clinical study	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7801	Photobiomodulation Therapy and Light-cured Resin Varnish as treatment for Cervical Dentin Hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-31	Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2q5dg2d	<NULL>	Volunteers of both genders; aged between 18 and 45 years; must present at least one premolar and at most eight premolars with cervical dentin hypersensitivity (CDH), with pain measured on the numerical rating scale (NRS) equal to or greater than 4 and with non-carious cervical lesion (NCCL) with a maximum depth of 1mm; volunteers with at least 20 teeth in occlusion	Volunteers with premolars with Cervical Dentin Hypersensitivity - CDH with active carious lesions; or with defective restorations; or with dental tissue loss requiring restorative treatment; or with pulp inflammation; or that serve as support for removable partial dentures or fixed prostheses; individuals undergoing ongoing orthodontic and periodontal treatment; those who report having received desensitizing treatment from a professional in the last six months or using desensitizing toothpaste in the last three months; those who have used anti-inflammatory drugs or analgesics at the time of recruitment; pregnant women or those who are breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-10qjnp65	Protein Supplementation in the Functional Rehabilitation of critical patients	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7805	Protein Supplementation Strategies in the Functional Rehabilitation of critical patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade de Pernambuco	Hospital Universitário da Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-10qjnp65	<NULL>	Patients admitted to the Intensive Care Unit - ICU; over 18 years old; of both sexes; with indication of the use of exclusive enteral nutritional therapy; and that they undergo early motor rehabilitation according to the institution&apos;s protocol (24 hours after admission to the ICU, without intracranial hypertension, in hemodynamic and respiratory stability)	Patients under 18 years of age; who are on oral feeding; parenteral or mixed; or who have some type of contraindication to undergoing motor physiotherapy; patients with suspected or confirmed brain death; patients in palliative care; pregnant women; patients who have contraindications for using the cycle ergometer (skeletal, dermatological or surgical dysfunction); and Body Mass Index (BMI) greater than or equal to 30kg/m² (obesity)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8kt9t54	The influence of practice with virtual video games on motor control and skill learning in young adults	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7811	The influence of Virtual Reality practice on motor control and skill learning in young adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de São Carlos - UFSCar	Universidade de São Paulo - São Carlos/SP	https://ensaiosclinicos.gov.br/rg/RBR-8kt9t54	<NULL>	Be young adults; aged 18-30 years); with no prior experience with the games included in the practice protocol of the present study, either on Xbox 360º Kinect™ or on real practice	Body Mass Index corresponding to the obesity condition; present any visual, musculoskeletal, physical and/or neurological changes that could compromise the performance of the assessments and practice sessions proposed in this study; be absent from any of the assessments and/or practice sessions; have prior experience with the games included in the practice protocol, both virtual reality and real practice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-5vxncn2	Use of ozone for tooth whitening in patients with tooth sensitivity: clinical and randomized study	Not yet recruiting	Intervention	2025-02-28	<NULL>	<NULL>	7814	Use of medicinal ozone for tooth whitening in patients with tooth hypersensitivity: clinical and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-20	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5vxncn2	<NULL>	Patients of both sexes will be included in the study; aged between 18 and 35 years; with all vital anterior teeth; never whitened or restored; with periodontal health; no history of spontaneous dental pain; that do not use toothpaste with desensitizing properties; with grade 1 to 3 dentin sensitivity;  willing to return for future evaluations during the research period	Patients with missing anterior teeth will be excluded from the study; affected by caries lesions; with the presence of recession; with some type of restorative or prosthetic treatment; or who use fixed orthodontic appliances; patients with bruxism or visible enamel cracks; patients with a history of periodontal disease or active periodontal disease; patients with a history of dental hypersensitivity; patients with tooth color changes due to fluorosis or tetracycline; patients who use many medications; and pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-3m77djm	Feasibility and effectiveness of a pre-operative home physical exercise Program in Osteoarthritis patients awaiting knee prosthesis Surgery	Not yet recruiting	Intervention	2025-02-28	<NULL>	<NULL>	7815	Feasibility and effectiveness of a physical exercise Program pre-operative homework in Osteoarthritis patients waiting for total knee Arthroplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-28	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-3m77djm	<NULL>	Participants eligible for the study will be those aged between 50 and 75 years; of both sexes; who report being able to perform the proposed exercises (table 1); who accept the terms of the informed consent form (ICF); who are not engaged in another physical exercise program; who do not present cardiovascular, metabolic, or musculoskeletal conditions unrelated to knee osteoarthritis that may prevent the execution of the evaluation tests and the home exercise program; who present a diagnosis of unilateral knee osteoarthritis according to the Ahlbäck classification modified by Keyes et al. (1992), being grade I reduction of joint space or grade II obliteration of joint space or grade III wear of the tibial plateau &lt; 5 mm in the anteroposterior plane and intact posterior part of the plateau in the sagittal section or grade IV wear of the tibial plateau from 5 to 10 mm in the anteroposterior plane and extensive wear of the posterior margin of the tibial plateau in the sagittal section or grade V severe subluxation of the tibia in the anteroposterior plane and anterior subluxation of the tibia &gt; 10 mm in the sagittal plane; who are classified as candidates for primary total knee arthroplasty; who have some means of direct contact or through a close relative to facilitate communication; in the case of patients in the experimental group, who have availability for telerehabilitation sessions, access to communication via WhatsApp, and conditions for conducting supervised videoconferences	Patients will be excluded if they present unexpected adverse events that compromise the safety or continuity of the home-based physical exercise program; if they do not attend the scheduled telerehabilitation sessions; if they do not respond to communication attempts via WhatsApp; if they do not achieve the minimum score required on the Mini-Mental State Examination (MMSE) adjusted to their educational level with a score below the cutoff value indicating cognitive impairment which may compromise the proper understanding of the home-based exercise program as well as the use of WhatsApp for conducting and monitoring activities; if they have a cancellation or rescheduling of the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-4433szt	What is the best surgical treatment for trigger finger? Minimally invasive technique with retinaculotome or open technique	Not yet recruiting	Intervention	2025-03-05	<NULL>	<NULL>	7816	Surgical treatment of trigger finger: minimally invasive technique with retinaculotome versus open technique. Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-25	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4433szt	<NULL>	Trigger finger in any of the five fingers; over 18 years old; both sexes; trigger finger greater than II according to the green classification.	Associated Dupuytren&apos;s disease; previous surgical treatment for trigger finger; patients with associated collagen or autoimmune diseases; presence of joint stiffness in the interphalangeal joints; previous tendon injuries or fractures of the metacarpals or phalanges	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-4w7tkh3	Study on the efficacy and safety of a nanotechnology product based on Rosemary essential oil with Ultrasound application in patients with knee Osteoarthritis	Not yet recruiting	Intervention	2025-03-07	<NULL>	<NULL>	7821	Efficacy and safety of Phonophoresis with Salvia Rosmarinus essential oil nanoemulsion in knee Osteoarthritis: a randomized, triple-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Empresa Brasileira de Serviços Hospitalares	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4w7tkh3	<NULL>	Clinical and radiological diagnosis of knee osteoarthritis according to the American College of Rheumatology criteria. Age 18 years or older. Both sexes. Ability to understand and sign the Informed Consent Form. Presence of knee pain for at least three months impacting functionality. Availability to attend study sessions throughout the intervention period	Previous diagnosis of rheumatoid arthritis, gouty arthritis, infectious arthritis, or other inflammatory joint diseases. History of prior surgery on the affected knee. Use of oral or intra-articular corticosteroids in the last six months. Presence of ulcers, skin infections, or lesions in the intervention application area. Severe neurological or psychiatric diseases that may compromise study participation. Pregnancy or lactation. Use of metallic devices in the knee preventing phonophoresis application. Participation in another clinical trial in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-9tt6s3p	The effect of Cat&apos;s Claw on inflammation, pain, and quality of life in women with endometriosis	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7828	Effect of Uncaria Tomentosa Supplementation on Markers of Inflammation and Oxidative Stress, Pain, and Quality of Life in Women with Endometriosis: A Randomized, TripleBlind, Placebo-Controlled Clinical Trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9tt6s3p	<NULL>	Adult women; between 18 and 49 years old; with symptomatic Endometriosis; diagnosed through laparoscopy and/or magnetic resonance imaging and/or transvaginal ultrasound with bowel preparation; with rejection of hormonal treatment, at least in the last 3 months	Women diagnosed with Endometriosis who are pregnant and/or lactating; are allergic to the Uncaria tomentosa plant; who have liver diseases such as hepatitis, gallstones, liver cirrhosis and hepatic steatosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-5z98vxb	Effects of different rehabilitation protocols in adults and elderly individuals with chronic post-Chikungunya joint pain	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7831	Efficacy of different rehabilitation protocols on biopsychosocial variables in adults and elderly people with chronic post-Chikungunya arthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5z98vxb	<NULL>	Individuals infected with the Chikungunya virus with chronic arthralgic symptoms (more than 3 months); pain level more than 0 on Visual Analogical Scale; of both sexes; aged over 18 years old	Individuals who present any contraindication to the proposed interventions; who do not respond to simple commands; who present arthralgic symptoms of origin other than Chikungunya virus infection; who are carrying out other physical treatment protocols or begin during the intervention; who use wheelchair-type walking aids or bedridden individuals who have some severe comorbidity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-10bfs3gm	Effects of Sports Training associated with Nutritional Intervention on adolescent health	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7832	Effects of Sports Training associated with Nutritional Counseling on cardiovascular risk factors in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-15	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10bfs3gm	<NULL>	Adolescents of both sexes; aged between 11 and 14; residing in Porto Alegre - RS and the metropolitan region; available to participate on determined days and times	Adolescents with any pathology or injury that limits the total or partial execution of the training protocol; using medications that influence the results (for example: statins, hypoglycemic agents or beta-blockers); pregnancy; who have been participating in some physical activity/exercise or following some nutritional counseling program for at least six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-8psxvsq	The effect of Laser Acupuncture and Strength Exercises on the pain and function of knee osteoarthritis in the elderly: a controlled, experimental and double-blind clinical trial	Not yet recruiting	Intervention	2025-03-12	<NULL>	<NULL>	7834	The effect of Laser Acupuncture and Progressive Resistance Exercises on pain and function of knee osteoarthritis in the elderly: a controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-06	Universidade Federal de São Paulo	Secretaria Municipal de Saúde de Santos	https://ensaiosclinicos.gov.br/rg/RBR-8psxvsq	<NULL>	Individuals of both sexes; aged 60 years and over; diagnosed with knee osteoarthritis according to the criteria of the American College of Rheumatology; experiencing knee pain between 3 and 8 on the numeric pain scale (NDS) in the last week	Use of metal prosthesis in the hip or knee region; cardiac pacemaker or other electronic implants; peripheral neurological deficit; uncontrolled systemic arterial hypertension; uncontrolled diabetes mellitus; continuous use of anti-inflammatories; steroid use; thrombotic or embolic changes in blood vessels; joint infiltration in the knee in the last 3 months; regular physical activity at the time of the research and any medical condition that prevents physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-4fcb4z4	Effectiveness of Tai Chi on patients with Chronic Neck Pain	Not yet recruiting	Intervention	2025-03-17	<NULL>	<NULL>	7842	Effectiveness of Tai Chi in patients with Nonspecific Chronic Neck Pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fcb4z4	<NULL>	Chronic nonspecific neck pain (defined as pain and discomfort) located in the neck region between the upper nuchal line and the scapular level for at least three months; age between 18 and 80 years; men and women may be included in the study; present pain intensity of at least three points on the numerical pain scale; reside in the region where the study will be conducted; the selected subjects will have to present sufficient knowledge of the Portuguese language to be able to answer the questionnaires	suspected or confirmed spinal diseases (e.g. tumor, infection, and fractures); history of spinal surgery; cardiovascular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-10hxhyfp	Technology Method in Postural Education for Schoolchildren and Teachers	Not yet recruiting	Intervention	2025-03-17	<NULL>	<NULL>	7843	Technology in Postural Education (TEP): Method for Approach of Students and Teachers	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-03-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10hxhyfp	<NULL>	Teachers of both sexes and different subjects from participating schools. Children and adolescents of both sexes, aged between 8 and 17 years old. Enrolled in and attending public and private schools in the city of Florianópolis, Santa Catarina. Literate students, with reading and writing skills. Individuals with access to the internet and an electronic device, such as cell phone, tablet, computer, notebook. Teachers and students whose parents and/or guardians sign the Free and Consent Form Informed (TCLE), Consent Form for Photographs, Videos and Recordings, students who sign the Consent Form	Students with motor and cognitive disabilities, previously acquired physical disabilities, congenital and neurological disorders. Students who do not attend 70% of the program&apos;s classes. Teachers who do not attend training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-4hskt2d	Effects of a preoperative home exercise program: physical-functional and hospital outcomes in patients undergoing knee surgery	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7847	Effects of a preoperative home exercise program: physical-functional and hospital outcomes in patients undergoing total knee arthroplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-21	Ministério da Saúde	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-4hskt2d	<NULL>	Patients diagnosed with knee osteoarthritis who have been selected for total knee arthroplasty by their physician; both genders; aged between 50 and 75 years; who have signed the Free and Informed Consent Form; able to perform the exercises proposed in the home training program; availability for telerehabilitation sessions and WhatsApp for supervised video conferences	Patients who do not respond to scheduled telerehabilitation sessions or communication via WhatsApp; patients who present unexpected medical complications that prevent continuity or safety in the exercise program will be instructed to immediately stop exercising and excluded from the study; changes in the clinical condition that result in surgical contraindication or new injuries during the pre-rehabilitation period that make participation in home exercises unfeasible will also be grounds for exclusion; patients who present scores below the values ​​suggested by the Ministry of Health in the Mini Mental State Examination (MMSE) due to the possibility of inability to adequately understand the tests and the intervention protocol; are involved in another physical exercise program that has a frequency equal to or greater than once a week; have any other medical condition that prevents safe participation in the exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-3njbh7w	Effects of Acupuncture on the scalp for pain relief, depression symptoms and impact on improving the quality of life of people with Fibromyalgia	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7850	Effects of Craniopuncture on pain, depression symptoms, and impact on quality of life of people with Fibromyalgia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-03	Programa de Pós-Graduação em Enfermagem da  Universidade Federal do Rio Grande do Norte	Programa de Pós-Graduação em Enfermagem da  Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3njbh7w	<NULL>	Patients with a diagnosis of fibromyalgia obtained through the International Classification of Diseases (ICD-10) code M79 will be included. 7; patients aged 18 years or older; both sexes	Individuals with impaired cognitive ability, who are unable to understand the questions in the questionnaires; those who have other causes of pain; those who have an insurmountable fear of needles	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-34qpgjn	The benefits of Physical Exercise and Blood Molecular Analysis as an intervention for reducing Kidney Toxins in patients with Chronic Kidney Disease: an exploratory study	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7851	The benefits of Physical Exercise and Biomolecular analyses as an intervention to reduce Uremic Toxins in patients with Chronic Kidney Disease: an exploratory study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-10	Strictu Sensu em Educação Fìsica	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-34qpgjn	<NULL>	Person diagnosed with chronic kidney disease and who have persistent albuminuria (&gt;300mg/g) following the KDIGO - Kidney Disease: Improving Global Outcomes guidelines; metabolic syndrome {i.e., type 2 diabetes mellitus, arterial hypertension (blood pressure&gt;180/100mmHg), overweight or obesity, and dyslipidemia}; do not have complications arising from preexisting clinical metabolic diseases (i.e., diabetic coma, ketoacidosis, hyperosmolarity, and/or uncontrolled diabetes), evaluated by a nephrologist; absence of neurodegenerative, osteomyoarticular diseases, lupus erythematosus, or congenital kidney disease; do not have apparent cardiovascular complications, such as heart failure, severe arrhythmia, angina, or cerebrovascular disease; do not have comorbidities that limit performance in physical tests or training; have not been engaged in physical exercise programs for at least six months prior to the start of the experimental protocol; have no smoking or alcohol consumption behavior; D-dimer values ​​within normal values ​​(220-500 ng/mL); patients of both sexes; and over 18 years of age	Practice physical exercise regularly; have suffered a stroke in the last 6 months and/or have autoimmune diseases; unstable cardiac dysfunctions, such as: non-stabilized coronary disease, aneurysm at risk of rupture, uncontrolled arrhythmia, uncontrolled hypertension (SystolicBloodPressure&gt; 190 mmHg and/or DiastolicBloodPressure&gt; 100 mmHg); infarction in the last 3 months;  infectious conditions, Hemoglobin lower than 8 in the last monthly routine hemodialysis exam; myoarticular pain; fever;  oxygen saturation (SpO2) at rest less than 94%; restriction of clinical staff will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-469x3sh	Multicenter study, before and after intervention, to test the end-of-life wishes card game in oncology residents and clinical oncologists	Not yet recruiting	Intervention	2025-03-20	<NULL>	<NULL>	7854	Awareness of oncology residents and clinical oncologists regarding the application of the Go Wish Cards Game for cancer patients: a multicenter pre and post-intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-07	Hospital de Câncer de Barretos	Instituto Nacional do Câncer	https://ensaiosclinicos.gov.br/rg/RBR-469x3sh	<NULL>	Oncology residents; of both genders; being in the second or third year of clinical oncology residency; being available to participate in three sessions of the Go Wish card game intervention; and clinical oncologists	Oncology residents and clinical oncologists who have participated in previous studies involving the Go Wish Card Game	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-108r7p2n	The influence of prior information on the effect of caffeine on reaction time of university students	Not yet recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7862	The influence of caffeine on the reaction time of university students	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-06	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-108r7p2n	<NULL>	university student; of both genders, that is, men and women; non-smoker; resident in the municipality of Jequié located in the state of Bahia; Brazil; over 18 years of age	volunteers who declare themselves to have diseases or use medications that interfere with movement or muscle activation and perception of visual and auditory stimuli; as well as individuals with upper limb amputations that make it impossible to handle and attach the reaction and strength measuring device	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-10365tqp	Pharmaceutical Care for patients with Leprosy	Not yet recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7863	Implementation of the Pharmacotherapeutic Follow-up Service for Leprosy Patients in an outpatient pharmacy at a university hospital	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-06-02	Pro Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-10365tqp	<NULL>	Patients with Leprosy treated at the Hospital das Clínicas of the Federal University of Minas Gerais; both genders; with no minimum or maximum age limit	Patients without Leprosy; patients with Leprosy not treated at the Hospital das Clínicas of the Federal University of Minas Gerais	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-3g2xxj2	Efficacy of Elastic Bandage on Pain and Quality of Movement in Patients with Knee Osteoarthritis	Not yet recruiting	Intervention	2025-03-26	<NULL>	<NULL>	7865	Efficacy of Tissue Flossing associated with Pilates on pain, function and quality of movement in patients with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3g2xxj2	<NULL>	Patients aged between 40 and 80 years, of both sexes, diagnosed with symptomatic knee osteoarthritis; chronic degenerative joint condition with persistent symptoms for more than 12 weeks; not practicing physical activity regularly for more than 150 minutes per week; clinical diagnosis of knee osteoarthritis confirmed according to the criteria of the American College of Rheumatology, including knee pain associated with at least three of the following aspects: age equal to or greater than 50 years; crepitus during knee movements; increased sensitivity to compression; decreased local heat; bone enlargement; morning stiffness lasting less than 30 minutes; radiological changes from grade 2 onwards according to the Kellgren and Lawrence criteria, classified as follows: grade 0 – no changes; grade 1 – doubtful reduction of the joint space with possible presence of osteophytes; grade 2 – possibility of reduction of the joint space associated with the definitive presence of osteophytes; grade 3 – permanent reduction of the joint space, formation of osteophytes, subchondral sclerosis and deformity of the bone structures; grade 4 – large formation of osteophytes, severe reduction of the joint space, marked subchondral sclerosis and permanent deformity of the bone structures; presence of pain measured by the Numerical Pain Scale with a score equal to or greater than 3 points; painful passive range of motion in one or more osteokinematic movements of the knee complex	Patients with asymptomatic knee osteoarthritis; history of previous surgery in the lower limbs; presence of neurological or infectious disorders; severe visual impairments that compromise functionality or safety during the intervention; use of prostheses in the lower limbs; inability to understand the Portuguese language; having undergone physiotherapy treatment or Pilates in the last three months; administration of corticosteroids or hyaluronic acid in the last twelve months; presence of uncontrolled hypertension or diabetes; presence of peripheral vascular disease with a history of deep vein thrombosis, stroke, or any condition that contraindicates peripheral compression; presence of allergies or dermatitis that prevent the application of the proposed technique​	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-58j2jmh	Analysis of heart rate in people with spinal cord injury using two types of arm bicycles and physical tests and its relationship with general health. A controlled study	Not yet recruiting	Intervention	2025-03-26	<NULL>	<NULL>	7866	Analysis of heart rate variability between two types of Cycle ergometers and between functional submaximal tests and their correlation with health status in individuals with spinal cord injury - Randomized controlled clinical trial - Phase I	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Departamento de Fisioterapia da Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-58j2jmh	<NULL>	Volunteers with spinal cord injury; both genders; aged between 18 and 50; neurological levels below the 6th spinal cord segment; complete or incomplete spinal cord injury; more than 6 months since injury; no regular physical activity; no physiotherapy	Volunteers with other associated neurological diseases; history of heart disease or lung disease; diagnostic hypothesis; who are unable to complete the tests for any reason such as withdrawal, hospitalization, infections, dermal, musculoskeletal, vascular or respiratory complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-9wrq8n7	Effects of two types of Exercise on Breast Cncer	Not yet recruiting	Intervention	2025-03-31	<NULL>	<NULL>	7870	Acute effects of Exercise performed in two shorter sessions versus one longer session over the course of a day on Plasma Myokines, Growth and Viability of Mammary Carcinoma Lineage Cells: a Clinical, Randomized and Crossover Study with patients with Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Hospital Imaculada Conceição	https://ensaiosclinicos.gov.br/rg/RBR-9wrq8n7	<NULL>	Woman; over 18 years of age; breast cancer patient undergoing radiotherapy; able to perform physical exercise according to medical evaluation	Have severe cardiovascular, metabolic or osteoarticular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-5qjhyk3	Influence of Non-invasive Electrostimulation using the Scalp Acupuncture technique on Hand Strength Potentiated by the Strength of the Opposite Finger	Not yet recruiting	Intervention	2025-03-31	<NULL>	<NULL>	7871	Influence of acute Non-invasive Cranial Electrostimulation using the Scalp Acupuncture technique on Overflow-potentiated Handgrip Strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-31	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5qjhyk3	<NULL>	Healthy volunteers; both sexes; age between 18 and 59 years; right motor preference; participants diagnosed with ischemic stroke on the left confirmed by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) scans; age between 40 and 79 years; right hemiparesis; minimum score of 50% on the Fugl Meyer scale	Left motor preference; orthopedic alterations; fear of needles; hemorrhagic tendencies; clinical instability; uncontrolled epileptic seizures; other associated neurological diseases; global aphasia; inability to understand the written and spoken portuguese language	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-3t38hq2	Effect of a beam walking training on balance control during gait in older adults with a history of falls: a randomized clinical trial	Not yet recruiting	Intervention	2025-04-01	<NULL>	<NULL>	7874	Effect of beam walking training on dynamic balance control during locomotion in even and uneven terrains in older adults: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3t38hq2	<NULL>	Men and women; age between 65 and 80 years; intellectual capacity to understand verbal commands and perform tasks; ability to stand and walk independently without the use of assistive devices; older adults who have experienced at least one fall in the last six months; a MiniBEST test score below the cutoff point for fall risk, adjusted for age	Uncontrolled severe musculoskeletal, sensory, neurological, or cardiovascular problems; visual impairments not corrected by glasses or lenses; cognitive deficits such as alzheimer&apos;s, dementia, and other conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-10h3vtwm	Cardiovascular and sensory responses during Passive Ankle Movement in Elderly individuals	Not yet recruiting	Intervention	2025-04-01	<NULL>	<NULL>	7875	Cardiovascular and perceptual responses during Passive Ankle Mobilization in Elderly individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital Israelita Albert Einstein	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-10h3vtwm	<NULL>	Both genders; age equal to or greater than 60 years; have no history of heart disease and do not have orthopedic problems; are not involved in the practice of regular systematic physical activity more than once a week over the last six months prior to the beginning of the study; do not have a body mass index greater than 30 kg/m2; have calf skinfold thicknesses of less than 20 mm due to the interference of adiposity in the penetration of light from the Near-infrared Spectroscopy (NIRS) probe; and are able to perform a passive ankle mobilization session	Participants who are smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-7rrrvjw	Effects of recreational Volleyball program in Obese adolescents	Not yet recruiting	Intervention	2025-04-02	<NULL>	<NULL>	7880	Effects of a 12-week recreational Volleyball program in Obese adolescents: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Instituto de Educação Física e Esportes	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7rrrvjw	<NULL>	Be between 12 and 17 years old; both genders; display body mass index &gt; 2 standard deviations above the specific for the age and se according to the World Health Organization reference medians; be in the final stages of the pubertal maturation	Have medical conditions that contraindicate participation in physical activities; the use of medication that influences the results observed; participation in structured exercise, nutrition or weight loss programs weight in the 6 months prior to the initial screening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-9dbk25m	ProMOVE Healthy Schools: Technologies for strengthening and integrating public policies for health promotion and integral education	Not yet recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7884	Health-Promoting Schools: Technologies for strengthening and integrating public policies for health promotion and integral education	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-07	Centro de Ciências da Saúde	Secretaria Municipal de Educação, Prefeitura de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-9dbk25m	<NULL>	Be a student at Full-Time Municipal Schools in Fortaleza, the capital of Ceará, Northeast Brazil; Be of both sexes; Be enrolled in the 6th to 9th grade of Elementary School; Be at least 10 years old; Agree to participate in the research	Do not fill out the questionnaire; Withdrawing from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-7w3g2b3	The cognitive effect of using Instagram vs. TikTok	Not yet recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7885	Comparison of the cognitive impacts of Instagram versus TikTok use among adolescents from different socioeconomic levels	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-30	Universidade Federal da Bahia - Faculdade de Medicina	Universidade Federal da Bahia - Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-7w3g2b3	<NULL>	Adolescent users of Instagram and TikTok for at least 6 months from the date of the first test administration; adolescents of Brazilian nationality; between 13 and 18 years old; of both sexes	Adolescents who do not use TikTok and Instagram; adolescents who started using Instagram and TikTok less than 6 months ago from the date of the first test administration; adolescents who are not Brazilian; younger than 13 and older than 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-563rqd9	Chronic effects of motor rehabilitation in Stroke survivors through Resistance Training and Neuromodulation	Not yet recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7887	Motor rehabilitation in Stroke survivors with severe functional impairments through Unilateral Eccentric Training combined with Cortical Neuromodulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Instituto de Física Gleb Wataghin	Instituto de Física Gleb Wataghin	https://ensaiosclinicos.gov.br/rg/RBR-563rqd9	<NULL>	Patients who suffered a stroke (type 1) more than 6 months prior to participation in the study; patients who have severe hemeparesis as a consequence of the stroke; both female and male patients; patients above 18 years old	Patients who have any type of metal inside their body (pins, pacemakers, metal prostheses, revolver bullets); patients who have any musculoskeletal injury on the affected or unaffected limbs; patients who had previous conditions such as seizures, head trauma, hearing problems, and cochlear implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-5g9j4pv	Acute effect of functional training on arterial rigidity and ambulatory blood pressure in elderly people with Hypertension	Not yet recruiting	Intervention	2025-04-04	<NULL>	<NULL>	7893	Acute effect of functional training on arterial rigidity and ambulatory blood pressure in elderly people with Arterial Hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-17	Programa de Pós-Graduação em Educação Física - PPGEF	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-5g9j4pv	<NULL>	Elderly people; men and women; hypertensive; sedentary or who had not practiced any type of physical training in the month prior to the start of the intervention; not have uncontrolled heart failure; Parkinson&apos;s; Alzheimer&apos;s; insanity; physical or visual disability; morbid obesity; Cancer; unstable angina; musculoskeletal disorders that limit the performance of exercises; must be under treatment with antihypertensive medications; have medical follow-up; sign the Free and Informed Consent Form	Not completing the functional training session; failing to perform ankle brachial index (ABI) exams; not performing ambulatory blood pressure mapping (ABPM) in the pre- and post-intervention moments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-43j2rh9	Effects of Extra-articular Reinforcement in Anterior Cruciate Ligament Reconstruction on the clinical and functional status of high-performance athletes	Not yet recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7902	Effects of ACL Reconstruction on the functionality of high-performance athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-43j2rh9	<NULL>	Be a federated athlete who has participated in one or more official competitions in the last two years; be between 18 and 45 years old; have an injury to the Anterior Cruciate Ligament – ACL, without compromising other ligament structures of the knee; have not undergone previous surgery on the affected joint; of either sex	Presence of post-surgical infection; inability to or refusal to perform follow-up assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-10j3s6pd	Cataract surgery in Glaucoma patients	Not yet recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7905	Monofocal Intraocular Lens versus Monofocal-plus Intraocular Lens in Glaucoma patients: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-10j3s6pd	<NULL>	Both gender; Open angle glaucoma and angle-closure glaucoma; cataract with surgical indication; intraocular pressure lower than 21mmHg, with or without medication use; visual acuity above light perception; mild glaucoma at functional and structural evaluation	Intraocular pressure above 21mmHg; high myopia or high hyperopia; axial length above 30mm or lower than 18mm; secondary glaucomas; macular diseases; central loss at visual field; need of antiglaucomatous surgery; use of oral acetazolamide	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-7pxmfjc	Acute effects of motor rehabilitation in stroke survivors through resistance training and neuromodulation	Not yet recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7907	Motor rehabilitation in stroke survivors with severe functional impairments through unilateral eccentric training combined with cortical neuromodulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Instituto de Física Gleb Whatagin	Instituto de Física Gleb Whatagin	https://ensaiosclinicos.gov.br/rg/RBR-7pxmfjc	<NULL>	Patients who suffered a stroke (type 1); patients who have severe hemeparesis as a consequence of the stroke; both female and male patients; patients above 18 years old	Patients who have any type of metal inside their body (pins, pacemakers, metal prostheses, revolver bullets); patients who have any musculoskeletal injury on the affected or unaffected limbs; patients who had previous conditions such as seizures, head trauma, hearing problems and cochlear impalants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-65p3f3s	Evaluation of the use of Topical Anesthesia in Thyroid surgery	Not yet recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7910	Evaluation of the use of Topical Anesthesia on the airway with Lidocaine and Ropivacaine in patients undergoing Total Thyroidectomy surgery: a randomized study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-06-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-65p3f3s	<NULL>	Patients undergoing total thyroidectomy; both genders; age between 18 and 70 years; American Society of Anesthesiologists (ASA) physical status classification I or II	Patients who refuse to participate in the study; difficult tracheal intubation (trachea not intubated after the first attempt); smoking patients; patients with heart, lung, or neurological diseases; patients with a history of previous laryngeal or tracheal surgery; patients at risk of aspiration of gastric contents; patients requiring the use of a nasogastric or orogastric tube	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-4w9jscv	The effectiveness of using Limb rotation band for treatment of Femoral anteversion in children with in-toeing: a randomized clinical trial	Not yet recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7911	Study and development of Orthosis for treatment of Femoral anteversion in children with In-Toeing: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4w9jscv	<NULL>	Children of both sexes; Age between 4 and 10 years; Present in-toeing pattern due to femoral anteversion; absence of neuromotor or behavioral alteration; gait angle less than -3° and internal rotation of the hip greater than 70°; do not present in-toeing due to internal torsion of the tibia and metatarsus adductus or excessive deformity indicating surgery (over 80° of internal rotation); do not present a history of surgery; fractures in limbs and deformities that affect gait (for example, clubfoot, dislocation of the hip joint)	Low adherence to daily use of the orthosis (less than 4 hours reported); presence of allergies or irritability when using the orthosis; orthopedic surgeries on lower limbs involving the hip; possible fractures in the lower limbs; interruption in the use of the orthosis for more than 15 total days or 7 calendar days; withdrawals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-7vfx9pv	Affective response to increasing and decreasing intensity physical exercise in adolescents	Not yet recruiting	Intervention	2025-04-10	<NULL>	<NULL>	7912	The affective response to physical exercise of different intensities in adolescents	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7vfx9pv	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-10jfkh7q	Promoting physical activity among economically disadvantaged adults	Not yet recruiting	Intervention	2025-04-14	<NULL>	<NULL>	7914	Promoting physical activity and equity: overcoming barriers to physical activity participation among economically disadvantaged adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-30	Programa de Pós-Graduação em Educação Física da Universidade Federal de Sergipe	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-10jfkh7q	<NULL>	Aged 18 years or older; all gender; not meeting physical activity guidelines (less than 150 minutes of moderate-to-vigorous physical activity per week); not having participated in any physical activity program in the past three months; intending to join a walking/running programme; and agree to the Informed Consent Form by signing it	Individuals with a condition that prevents them from engaging in physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-9nkrhy6	Evaluation of the effects of transcranial magnetic stimulation on postural control in patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2025-04-15	<NULL>	<NULL>	7918	Effects of transcranial magnetic stimulation on postural control of Parkinson&apos;s patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-10	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9nkrhy6	<NULL>	Individuals aged 18 years or older; regardless of gender; who have a clinical diagnosis of Parkinson&apos;s disease, classified as mild to moderate; who have a medical diagnosis of the disease for at least six months; ability to attend scheduled sessions and availability to participate in all stages of the study, including assessments and interventions	Individuals who do not complete the assessments or any stage of the research project, carrying out the tests and applying the questionnaires proposed by the research project; who have a number of absences in interventions greater than 25%; individuals with relative or absolute contraindications to transcranial magnetic stimulation, such as a history of epilepsy or seizures, presence of implanted metal or electronic devices; individuals with severe cognitive deficits, identified during screening, that prevent understanding of the procedures or participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-9jwzn8d	Evaluation of  virtual reality to reduce anxiety before surgery in adult	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7926	Evaluation of immersive virtual reality for reducing preoperative anxiety and increasing satisfaction in adult surgical patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital Santa Cruz Sociedade Anonima	Faculdade Evangélica Mackenzie do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9jwzn8d	<NULL>	Patients of both sexes; aged between 18 and 80 years; with  cognitive ability to interact with the glasses and answer the questions	Patients with hearing or visual impairment; patients with facial infections; or with a history of seizures or migraines; those whose proposed surgeries are due to neoplasms; those requiring intensive care unit admission in the immediate postoperative period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7v86hk9	Impact of caffeine intake on mental, cognitive and affective health during a strength training session	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7928	Evaluation of the effect of acute caffeine Supplementation on affective parameters, cognition, anxiety and mood during a strength training session in an adult population	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-20	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-7v86hk9	<NULL>	Adults; both genders; with or without a diagnosis of Common Mental Disorder; age between 18 and 45 years old; be performing Strength Training for at least 6 months prior to the participant&apos;s first visit	Adults diagnosed with Osteoarthritis; Rheumatoid Arthritis; Infected with HIV Virus; Musculoskeletal Diseases that prevent physical exercise; Hypertensive; people with Cardiovascular Diseases; Pregnant women; Breastfeeding women; Ulcer sufferers; carriers of Gastrointestinal Inflammatory Diseases; volunteers who use Theophylline and Aminophylline, Anticonvulsants, Central Nervous System stimulant drugs such as Methylphenidate (Ritalin® and Concerta®), Lisdexamfetamine (Venvanse®, Juvene®), Bupropion Hydrochloride (Wellbutrin XL®, Zetron XL®, Bup), Lithium Carbonate (Carbolitium®); Smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7n2w7zt	Ankle exercises on muscle responses in athletes and active adults	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7929	Effect of short-foot on musculoskeletal responses in athletes and recreationally active adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-7n2w7zt	<NULL>	Adult volunteers of both sexes; must not engage in any physical activity other than that proposed in the experiment; must be free from functional limitations that would prevent them from performing the tests and/or the proposed protocol; and must engage in less than 300 minutes of physical activity per week	Must not be consuming caffeine-based or stimulant ergogenic aids; must not report any acute dizziness; must not present abnormal fluid accumulation (edema), particularly in the lower limbs; must not have been diagnosed with conditions affecting postural control, such as vestibular dysfunction, Alzheimer’s disease, Parkinson’s disease, or motor neuron disorders; must not have a history of lower limb trauma in the past year; and must not be currently engaged in a structured exercise program focused on postural control	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-328krjg	Impact of neuromodulation on cognitive functions altered in Attention Deficit Hyperactivity Disorder (ADHD)	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7932	Impact of High-Definition Transcranial Electrical Stimulation with Alternating Current on Executive Functions in individuals with Attention Deficit Hyperactivity Disorder	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-10-01	Campus Integrado de Manufatura e Tecnologia - CIMATEC / SENAI	Campus Integrado de Manufatura e Tecnologia - CIMATEC / SENAI	https://ensaiosclinicos.gov.br/rg/RBR-328krjg	<NULL>	Provision of Free and Informed Consent in writing, signed and dated; provision of the assent term in writing, signed and dated; individuals of both sexes; right-handed; aged 12-18 years; diagnosed with Attention Deficit Hiperativity Deficit (ADHD) according to DSM-V criteria; residing in Salvador and the metropolitan area; enrolled in regular school or who have already completed high school; and who have medical authorization to suspend the use of psycho-stimulant medication for 48 hours prior to the interventions and for an additional 5 days during the intervention period. Individuals of both sexes; aged 12-18 years; without a diagnosis of ADHD; residing in Salvador and the metropolitan area, enrolled in regular school or who have already completed high school.	Research participants who have been involved in clinical study protocols in the last 12 (twelve) months, unless the investigator deems there may be a direct benefit to them (CNS Resolution 251, dated August 7, 1997, item III, subitem J); alcohol and drug abuse (previous diagnosis according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders – DSM-V); use of illegal drug; any clinical condition interpreted by the investigating physician as a risk for the participant’s inclusion in the study, presence of head injuries contraindicating the use of neuromodulation; use of pacemakers; cochlear implants, or metal plates in the head; brain tumors; cranial deformities; diagnosis of depression and/or anxiety disorders, according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V), in the last 6 months; diagnosis of bipolar disorder, schizophrenia, autism spectrum disorder, and other developmental disorders diagnosed according to DSM-V; diagnosis of epilepsy; pregnant individuals; diagnosis of ADHD only with hyperactive presentation; initiation of new psychotropic medications or changes in the dosage of usual medication in the last 3 months; ose of psycho-stimulants 48 hours before and during the intervention; Oral language disorders and cognitive disorders that hinder understanding of the study procedures and the necessary responses; individuals who have suffered acquired neurological disorders or have congenital neurological disorders that may interfere with understanding the study results: cerebrovascular accidents, encephalopathies; visual or auditory impairments that prevent effective use of Virtual Reality; Episodes of nausea and labyrinthitis that, even when treated, hinder the use of Virtual Reality; any condition that, in the opinion of the principal investigator, poses a risk to the research participant during their participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-44cdrz2	Study on the acceptability and effectiveness of a Denture Adhesive Cream	Not yet recruiting	Intervention	2025-04-17	<NULL>	<NULL>	7937	ORC_128728_EN24-0214-01_Dental acceptability evaluation with perceived effectiveness for health product	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Kley Hertz Farmacêutica S.A	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-44cdrz2	<NULL>	Healthy volunteers; both genders; aged between 18 and 70 years; users of removable dental prostheses; who have used or currently use adhesive creams; agreement to follow the study procedures and attend the center on specified dates and times for evaluations; understanding, consenting, and signing the informed consent form	Pregnancy or risk of pregnancy, breastfeeding; use of anti-inflammatory, immunosuppressive, antihistamine drugs up to 3 weeks prior to selection; atopic history or allergies to health products in this category; active pathologies and or skin lesions (localized and or widespread) in the evaluation area; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or drug abuse; known history or suspected intolerance to products in the same category; Intense sun exposure up to 15 days prior to the evaluation; aesthetic or dermatological treatments up to 4 weeks prior to the evaluation; other conditions considered by the investigator as reasonable for disqualification from study participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-58gw8gg	At-home Bleaching with 5% versus 10% Carbamide Peroxide: a randomized, split-mouth, triple-blind, non-inferiority controlled trial	Not yet recruiting	Intervention	2025-04-17	<NULL>	<NULL>	7939	Comparison of bleaching efficacy of 5% vs. 10% Carbamide Peroxide: a randomized, split-mouth, triple-blind, non-inferiority controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-58gw8gg	<NULL>	Patients must be 18 years or older. Both sexes. Being in good general and oral health. With no carious lesions, restorations, or endodontic treatment in the maxillary anterior teeth. The maxillary canines must have a shade of A2 or darker according to the value-oriented Vita Classical shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients already undergoing tooth whitening; undergoing orthodontic treatment; with severe discoloration due to tetracycline stains and fluorosis; participants with any other pathology that could cause sensitivity (such as recession, exposed dentin or presence of visible fissures in the teeth) or history of hypersensitivity;  pregnant and lactating women; patients with dental bruxism; taking analgesics or anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9mqpwbw	Cardiac control after Pediatric Heart Surgery	Not yet recruiting	Observational	2025-04-21	<NULL>	<NULL>	7940	Cardiac autonomic control in the postoperative period of Pediatric Cardiac Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9mqpwbw	<NULL>	Children and adolescents diagnosed with congenital heart disease; of both sexes; aged between the first day of life and 17 years, 11 months and 29 days; who do not use a cardiac pacemaker; and with acceptance of the consent form by the child&apos;s legal guardians, and the assent form by the child over 2 years old	Inability to remain with the polar capture device for a specified period of time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-2nzh9vr	Use of music and ice compress for pain relief in the postoperative cardiac period	Not yet recruiting	Intervention	2025-04-21	<NULL>	<NULL>	7942	Effectiveness of the association of music and cryotherapy in pain relief in mediastinal drain removal after myocardial revascularization: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-10	Departamento de Enfermagem	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2nzh9vr	<NULL>	Being in the post operative of myocardial revascularization surgery; being hemodynamically stable and with Glasgow 15; of both sexes; be able to be assessed using pain scales; be over 18 years old; not have any neurological or cognitive condition that could influence the application of the intervention	Use of continuous sedation or analgesics; opioid use for chronic pain; narcotics addiction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-25rft3r	Effect of moderate-paced music on walking ability and muscle metabolism in people with Peripheral Arterial disease	Not yet recruiting	Intervention	2025-04-23	<NULL>	<NULL>	7946	Effect of medium-pace music on walking ability and muscle metabolism of claudicating individuals with Peripheral Arterial disease: a quasi-experimental study	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-25rft3r	<NULL>	Homens e mulheres; Age ≥ 18 years; Diagnosis of peripheral arterial disease with ankle-brachial index &lt; 0.90 at rest; Individuals without physical and cognitive limitations for performing and understanding the procedures; In case of hearing impairment, the participant may only participate if they have correction by a prosthesis that guarantees their exposure to sound stimuli	Participants with clinical conditions that contraindicate physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-4mp6nvg	Evaluation of a nutritional education program to prevent childhood obesity in Guaíba, Rio Grande do Sul	Not yet recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7950	Evaluation of a community intervention program for food and nutrition education to prevent childhood obesity in the municipality of Guaíba, Rio Grande do Sul: a randomized field trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-4mp6nvg	<NULL>	Volunteers aged between 4 and 6 years old; both genders; enrolled in preschool education; residents of the municipality of Guaíba; parents and guardians of preschoolers; preschool teachers; health agents working in the school health program	Volunteers in wheelchairs; volunteers diagnosed with cerebral palsy; volunteers diagnosed with autism spectrum disorder; volunteers diagnosed with Down syndrome; volunteers diagnosed with heart disease; volunteers diagnosed with endocrine diseases; teachers and health agents of the school health program who have sick leave; teachers and health agents of the school health program who have maternity leave	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7gs22jk	Food and the heart: the benefits of a Nutritional Intervention for people with Heart Failure	Not yet recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7952	Effect of a Nutritional Intervention on clinical, laboratory and quality of life parameters of patients with Heart Failure: 6-month follow-up	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Hospital Universitário da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7gs22jk	<NULL>	Agreement to participate in the study and signing of the Free and Informed Consent Form - TCLE. Patients diagnosed with Heart Failure - HF. HF with slightly reduced ejection fraction or HF with reduced ejection fraction, with ventricular ejection fraction less than 50%, according to the last echocardiogram performed. Patients over 18 years of age. Both sexes. Patients free of decompensation due to HF for at least 3 months before inclusion in the project	Pregnant women. Breastfeeding women. Patients with limitations in understanding the guidelines: such as the presence of cognitive disorders or difficulties in reading or understanding the booklet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-4596xc2	Comparison of the effects of prescribed physical exercise after an evaluation performed using a treadmill walk test versus the Six-Minute Walk Test in a corridor in patients with coronary artery disease: a randomized controlled clinical study	Not yet recruiting	Intervention	2025-04-27	<NULL>	<NULL>	7959	Comparison of the adaptations induced by physical training prescribed based on the cardiopulmonary exercise rest and the six-minute walk test in patients with coronary artery disease: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-30	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4596xc2	<NULL>	Volunteers diagnosed with coronary artery disease; over 18 years old; no restrictions regarding gender	Volunteers with contraindications for moderate physical training; contraindications for performing any of the assessment methods; orthopedic limitations; non-adherence to pharmacological treatment; non-adherence to the cardiovascular rehabilitation program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-3hsqzqz	Research using technology to promote healthy eating among teenagers	Not yet recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7966	Clinical trial using Digital Technology to promote healthy eating among adolescent students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-3hsqzqz	<NULL>	Adolescents must be attending high school and be regularly enrolled in the selected school; have a smartphone and internet access and use WhatsApp; the teenager signs the Term of Free and Informed Assent - TALE and have parental consent by signing the Institution&apos;s Consent Form - TCLE; age between 15 and 19 years old; both sexes	Adolescents who have physical and/or mental limitations that may prevent their participation during the program evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-73dm94r	Efficacy of Light Therapy in Temporomandibular Dysfunction in people with different skin tones: a clinical study	Not yet recruiting	Intervention	2025-04-29	<NULL>	<NULL>	7969	Effectiveness of Photobiomodulation Therapy on Temporomandibular Dysfunction in patients with different skin phototypes: a double-blind randomized controlled trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-73dm94r	<NULL>	Age between 18 and 55 years; female gender; presence of reported pain in the facial region lasting at least three months; and presence of a diagnosis of myofascial pain according to the evaluation criteria of the revised version of the Diagnostic Criteria for Temporomandibular Disorders - DC/TMD (Axis I, categories Ia and Ib)	Women who are receiving any treatment for Temporomandibular Disorders or accumulate simultaneous interventions outside of this protocol; have a history of tumor, trauma or head and neck surgery; a previous diagnosis of fibromyalgia or other painful musculoskeletal syndromes; neurological and psychiatric disorders; use of anxiolytics, antidepressants and anticonvulsants; or who are pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-4k29x2f	Effects of Bodybuilding Exercise performed at night on sleep in adults	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7973	Effects of a Resistance Exercise session performed earlier versus later at night on sleep in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4k29x2f	<NULL>	Being between 20 and 55 years old; both sexes; doing resistance exercises more than 2 days a week	Cardiovascular, respiratory, osteoarticular diseases; use of medications; smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-5nfv46m	Innovation in health: analysis of physiological signals for the prevention and monitoring of Cardiovascular and Metabolic Diseases	Not yet recruiting	Observational	2025-04-30	<NULL>	<NULL>	7974	Geometric Analysis and Spectral Topology of Physiological Markers for preclinical indicators of Cardiovascular Diseases and Metabolic Syndrome in young and adult individuals	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-02	Centro Acadêmico de Vitória - Universidade Federal de Pernambuco	Centro Acadêmico de Vitória - Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5nfv46m	<NULL>	Adult individuals aged between 25 and 55 years old, of both genders, with preclinical or clinical diagnosis of cardiovascular disease (type 2 diabetes and hypertension), may present with comorbidities such as dyslipidemia or overweight and obesity. Control group – adult individuals aged between 25 years and 55 years old, of both genders, with no cardiovascular diagnosis	Individuals who are hospitalized or in the acute phase of the disease; who present any motor impairment; or who refuse to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-8gxt823	Use of Calendula and Chamomile in the prevention and treatment of Skin Irritation caused by radiotherapy in patients with head and neck cancer: clinical study	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7977	Use of Calendula and Chamomile in the prevention and treatment of Radiodermatitis in patients with head and neck cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Liga Norteriograndense Contra o Câncer	Liga Norteriograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-8gxt823	<NULL>	Be 18 years of age or older; both sexes; have a histologically proven diagnosis of head and neck neoplasia with indication for radiotherapy treatment associated with chemotherapy; no previous history of antineoplastic treatment; no previous history of radiotherapy in the same field/treatment site; intact and continuous skin in the head and neck region on the first day of radiotherapy treatment	Interrupt oncological treatment for a period longer than eight days; use of any other type of product on the skin in the area undergoing radiotherapy treatment; have any type of allergy or hypersensitivity to EFA, calendula or chamomile	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-7qbb4bf	Evaluation of Caffeine and Sodium Bicarbonate in Athletes	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7978	Evaluation of the Effects of Caffeine and Sodium Bicarbonate in Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-21	Faculdade de Ciências da Saúde da Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7qbb4bf	<NULL>	Healthy volunteers; both genders; non-smokers; age between 18 and 40 years old	Smoking volunteers; history of alcohol or drug abuse; diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-6vkwsjx	The effects of non-invasive cerebral electrical stimulation associated with cardiorespiratory training on blood pressure parameters, respiratory rate, functional capacity and muscle strength in sedentary individuals	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7979	Effects of tDCS associated with cardiorespiratory training on hemodynamic parameters, functional capacity and muscle strength in sedentary people: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-05	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6vkwsjx	<NULL>	Volunteers of both sexes; insufficiently active sedentary identified by global physical activity questionnaire; aged between 18 and 50 years	Volunteers active smokers; seizure history; pregnancy; signs of severity and/or indications for hospitalization; diagnosis of epilepsy or use of anticonvulsants; recent heart surgery (less than 3 months); unstable angina; clinical diagnosis of aneurysm; uncontrolled hypertension; metallic implants; tumor; previous brain surgery; important cranioencephalic anatomical alteration; chronic degenerative lower limb disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-3x9gb8s	Effects of body vibration combined with respiratory physiotherapy in patients with pulmonary emphysema and osteoporosis: a controlled clinical study	Not yet recruiting	Intervention	2025-05-05	<NULL>	<NULL>	7982	Evaluation of the efficacy and safety of a whole-body vibration protocol combined with pulmonary rehabilitation on the functional capacity and bone quality of patients with Chronic Obstructive Pulmonary Disease: a prospective randomized controlled single-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3x9gb8s	<NULL>	Sign the informed consent form thus authorizing their participation in the research; participants with a  diagnosis of Chronic Obstructive Pulmonary Disease; men or women; age over 45 years; they will need to walk without assistance or supervision from others even if they use some type of walking aid	Hypercalcemia; severe vitamin D deficiency (25-hydroxyvitamin D &lt; 12 nanograms per milliliter); uncompensated thyroid function disorders; creatinine clearance &lt; 45 milliliters per minute; recent history of hip fracture (&lt; 12 months); alcohol or illicit drug dependence; use of teriparatide; calcitonin; androgens; estrogens or selective estrogen receptor modulators in the past 6 months; use of bisphosphonates in the past 12 months; osteoarthritis with synovitis; use of osteoarticular prostheses; severe heart failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-7d5bnmb	Vagus nerve stimulation in the auricular region for the treatment of patients with Temporomandibular Dysfunction – Pilot Study	Not yet recruiting	Intervention	2025-05-06	<NULL>	<NULL>	7985	Noninvasive Auricular Vagal Electrical Stimulation for the treatment of patients with Temporomandibular Dysfunction – Pilot Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-30	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-7d5bnmb	<NULL>	Adults aged 18 years or older; both sexes; diagnosis of temporomandibular dysfunction by the Diagnostic Criteria; completion of the free and informed consent form; change in heart rate variability with sympathetic or parasympathetic index outside the normal range (-1 to 1), in at least 2 of the 3 orthotest moments; minimum pain level of 4 considering an average of 4 values: greatest pain in the last week, least pain in the last week, average pain in the last week and current pain, all on a visual analogue scale from 0 to 10	Neurological impairment; rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis; cardiac arrhythmia or other cardiovascular conditions using beta-blockers; pregnant women or women who are breastfeeding; patients diagnosed with cancer; epilepsy; skull, cervical or rib fractures; severe osteoporosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-106nnmgg	Auriculotherapy for postpartum pain relief – a randomized clinical trial	Not yet recruiting	Intervention	2025-05-07	<NULL>	<NULL>	7990	Efficacy and acceptance of auriculotherapy for pain relief in the immediate postpartum period at the university hospital of Florianópolis - a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-29	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-106nnmgg	<NULL>	Vaginal delivery or cesarean section performed at Universitary Hospital (HU) of Universidade Federal de Santa Catarina (UFSC); age between 18 and 50 years; live newborn; agreement to participate in the study; sign the informed consent form	Severe medical complications in the postpartum period; history of severe psychiatric disorders or cognitive impairment; presence of piercings or similar items at the acupuncture point sites; contraindications for auricular acupuncture (infections at the application site, known allergies); additional surgeries or procedures (tubal ligation, hysterectomy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-752fqvj	Evaluation of the effects of Three ways of Teaching Torrect Pelvic Floor Muscle Contraction in women: a randomized controlled clinical trial	Not yet recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7991	Evaluation of the effects of Intracavitary and Extracavitary Perineal Awareness in women: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-752fqvj	<NULL>	Women over 18 years of age; having had sexual intercourse with vaginal penetration	Not knowing how to read and not being able to answer the questionnaires; having a urinary tract infection; having purulent and yellowish vaginal discharge; having undergone previous pelvic radiotherapy; having neurological disease; having pain during vaginal penetration during sexual intercourse; knowing how to contract the pelvic floor correctly and not accepting to participate in the research and/or not signing the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:16
RBR-536hkwg	Effects of Laser on pain and return of sexual function after postpartum Perineal Trauma: a feasibility study	Not yet recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7994	Effects of Photobiomodulation on pain and return of sexual function after obstetric spontaneous Perineal Laceration: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital Universitário Cassiano Antonio Moraes (HUCAM) da Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-536hkwg	<NULL>	Postpartum women treated at the Maternity of Hospital Antônio Cassiano de Moraes (HUCAM); normal birth with spontaneous perineal laceration of any degree; Singleton pregnancy; aged 16 or over; completion of the free and informed consent form	Infectious disease; hemorrhoid; bruise or varicose veins in the perineum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-2m9r3j2	How consuming a yerba mate (ilex paraguariensis) extract can impact nutrition, metabolism, inflammation, and oxidative balance in overweight people	Not yet recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7996	Effects of ingesting a yerba mate extract (ilex paraguariensis) on nutritional, metabolic, inflammatory parameters, and oxidative status in overweight individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-2m9r3j2	<NULL>	Men and women; age range between 40 and 65 years; without a history of cardiovascular disease; non-smokers or individuals who quit smoking in the past 3 years; individuals willing to maintain their usual diet and physical activity; individuals willing to maintain their habitual consumption of beverages rich in polyphenols (yerba mate, teas, coffee, wine, cocoa, soy milk, and fruit juices) during the study; individuals not using hypoglycemic, antihypertensive, or cholesterol-lowering medications; individuals who are overweight or obese (BMI ≥ 25 to 34 kg/m²); individuals who discontinued nutritional counseling at least 3 months ago or who are undergoing nutritional treatment but have not experienced weight changes &gt;5% in the last 3 months.	Diagnosis of uncontrolled metabolic or endocrine disorders; individuals who have undergone obesity surgery; postmenopausal women; pregnant and breastfeeding women; use of antipsychotics; those following vegetarian or vegan diets; individuals using probiotics or dietary supplements with antioxidant properties; those with weight fluctuations greater than 10% in the past three months; undergoing treatment for excess body weight (current low-calorie diet or nutritional treatment); smokers or chronic alcohol users; severe arterial hypertension, history of cardiovascular disease with clinical complications such as acute myocardial infarction and other coronary diseases; individuals with known malignant neoplasms, gastrointestinal diseases, kidney disease, and/or liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-2fsnrrb	Chronic®: A Study to Strengthen Muscle Health in Patients with Sarcopenia	Not yet recruiting	Intervention	2025-05-14	<NULL>	<NULL>	8004	Evaluation of the efficacy and safety of chronic® nutraceutical on muscle mass and functionality in patients with sarcopenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-07	Universidade Federal do Amapá	Hospital Universitário da Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-2fsnrrb	<NULL>	Individuals between 65 and 80 years old; With a SARC-CalF score &gt; or = 11 points, suggestive of sarcopenia (Barbosa-Silva et al, 2016); • Minimum score on the Mini Mental State Examination &gt; 24 points; • Capacity to consent: ability to provide written informed consent; • Medication stability: participants who are on a stable medication regimen (no changes in the last 4 weeks before the start of the study), if during the follow-up they require a substantial change in the medication regimen, the participant may be excluded.	Serious medical conditions: Individuals with serious medical conditions that could interfere with safe participation in the study or interpretation of the results, such as unstable heart disease, severe renal or hepatic impairment. Supplement use: Use of other nutraceutical supplements or changes in usual supplementation in the last 4 weeks before the start of the study. Neurological diseases that affect mobility or muscle strength. Active cancer: Patients diagnosed with active cancer or undergoing treatment for cancer in the last 5 years. Recent dietary changes: Significant changes in diet in the last 3 months. Participation in other studies: Participation in other clinical studies in the last 6 months. Individuals who perform intense physical activity or strength training regularly (more than 3 times per week) in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-2d2j5wp	A proposal for an ecological assessment of the affective response to increasing and decreasing intensity physical exercise in adolescents	Not yet recruiting	Intervention	2025-05-16	<NULL>	<NULL>	8007	The affective response to physical exercise of different intensities in adolescents	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-05-19	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2d2j5wp	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-8phx8f5	Influence of melatonin on physiological responses and physical performance during and after running	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8016	Effect of acute melatonin administration on physiological parameters and physical performance during and after running under different conditions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal de São Carlos	Laboratório de Fisiologia Endócrina e Exercício Físico	https://ensaiosclinicos.gov.br/rg/RBR-8phx8f5	<NULL>	The sample will consist of male and female runners; aged between 18 and 35 years; who are apparently healthy; physically independent; asymptomatic; normotensive; non-obese (body mass index lower than 30 kilograms per square meter and body fat percentage lower than 20%); non-users of tobacco or alcohol; moderately active (engaging in at least 150 minutes of physical activity per week, preferably running); and regularly participating in running programs	Volunteers who self-report the following conditions will be excluded: cardiovascular diseases; metabolic disorders; sleep disturbances; musculoskeletal injuries or any neuromuscular disorders affecting the lower limbs that would impair participation; use of dermatological medications (for example, creams, ointments, and lotions); antipyretics or diuretics and/or use of ergogenic substances (for example, anabolic-androgenic steroids) within the six months prior to the study. Due to the potential influence of subcutaneous fat on the signals obtained through near-infrared spectroscopy, individuals with skinfold thickness greater than 20 millimeters in the regions of interest will also be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6j752hm	Cervical manipulation and muscle and brain responses	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8017	The effect of upper cervical manipulation in physically active adults	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-6j752hm	<NULL>	Healthy male volunteers aged between 18 and 50 years; no functional limitations or medical conditions that could compromise their health or confound the study results; no abnormal fluid accumulation (edema), particularly in the lower limbs; no evidence of basilar artery impairment that would contraindicate cervical spinal manipulations	Not currently pregnant or breastfeeding; no self-reported history of neurological disorders; no reports of acute dizziness episodes; no severe visual impairments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6v9q8ft	Efficacy of Anesthetic Eye Drops for Oral Anesthesia in children: a clinical study	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8020	Efficacy of Ophthalmic Anesthetic for topical use in pediatric dentistry: randomized controlled clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-6v9q8ft	<NULL>	Healthy children; of both sexes; aged between 8 and 12 years; who require dental procedures with infiltration anesthesia in the posterior region of the maxilla; treated at the pediatric dentistry outpatient clinic of the Federal University of Piauí	Patients who are feeling pain at the time of the clinical examination; with a history of allergy to benzocaine or oxybuprocaine; who have used analgesics or anti-inflammatories up to 24 hours before the procedure; with syndromes or behavioral changes; those whose parents/guardians do not authorize participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-4yn9vmm	Efficacy of laser treatment for obstructive sleep apnea - clinical trial	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8023	Efficacy of non-ablative treatment with combination of Nd:YAG and Er:YAG lasers for sleep-disordered breathing analyzed by clinical and molecular parameters - controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-15	Faculdade de Odontologia da Universidade de São Paulo	Sistema Nacional de Laboratórios de Fotônica	https://ensaiosclinicos.gov.br/rg/RBR-4yn9vmm	<NULL>	Men and women; aged between 25 and 65 years; regardless of race or social class; who are at risk of obstructive sleep apnea by screening with the Stopbang questionnaire; with a minimum wash out of six months for other therapies for sleep-disordered breathing; who agree to participate in the study with signature of the free and informed consent form	Undergoing medical treatment or treatment for sleep-related breathing disorders; smokers; alcoholics; cancer patients; with diagnosed lung problems; with heart disease; using more than two antihypertensive drugs; with pharyngeal or nasal obstructions that require strictly surgical resolution; with previous surgery in the oropharynx region; pregnant or lactating women; history of photosensitivity (allergies); using photosensitive medication; Body mass index (BMI) above 40 kg/m2; participants who are unable to attend treatment sessions or follow-up appointments; or who do not perform follow-up exams as indicated by the researchers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-45vy5p3	How Home Exercises with online guidance can help elderly people with Neck Pain during the COVID-19 pandemic	Not yet recruiting	Intervention	2025-06-03	<NULL>	<NULL>	8032	Effects of Home-based Therapeutic Exercises via teleconsultation on Neck Pain complaints in elderly individuals during the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Centro de Ciências da Saúde da Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-45vy5p3	<NULL>	Individuals aged 60 years or older; of both sexes; with complaints of chronic cervical pain; who are actively enrolled in Open University for the Third Age (UNATI) and the waiting list of the Physical Therapy School Clinic (CEFISIO); and who have access to the internet via a mobile phone, tablet, or computer	Candidates who have generalized chronic pain syndrome (fibromyalgia); neurological diseases; decompensated systemic diseases; presence of chronic postural deformities; have undergone surgery or have trauma in the cervical spine region; active cancer; severe vestibular diseases that increase the risk of falls; severe visual impairment; musculoskeletal and vascular pathologies that contraindicate the proposed exercises; a history of psychiatric disorders that may interfere with the data to be collected; currently undergoing physiotherapy treatment for cervical pain; use of opioid analgesics (e.g., morphine, tramadol, hydromorphone, fentanyl, and others) at the time of data collection or within the past three months; and those showing any cognitive impairment verified through cognitive screening during the triage process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-4skswkf	Ultrasound-guided puncture versus conventional puncture of arteriovenous fistula	Not yet recruiting	Intervention	2025-06-04	<NULL>	<NULL>	8035	Ultrasound guided cannulation versus standard cannulation in arteriovenous fistula access: pilot and feasibility study of a crossover clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Escola de Enfermagem de Ribeirão Preto	Fundação Santa Casa de Misericórdia de Franca	https://ensaiosclinicos.gov.br/rg/RBR-4skswkf	<NULL>	Adult patients aged between 18 and 80 years; with a native arteriovenous fistula; recently created and without any previous puncture	Patients who present an arteriovenous fistula outside the maturation period and using grafts (prostheses)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-4j8p3wq	Joint manipulation on lung and heart	Not yet recruiting	Intervention	2025-06-09	<NULL>	<NULL>	8039	Joint adjustment in the functions of the lungs and heart in post-COVID-19 patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-4j8p3wq	<NULL>	Not engage in any physical activity outside of that proposed in the experiment; not be pregnant or breastfeeding; be free of functional limitations that would interfere with the performance of the experimental conditions; be free of any condition that could influence the experimental procedures or the interpretation of the resulting data; not present with abnormal fluid accumulation (edema), particularly in the lower limbs; have no basilar artery impairment that would contraindicate cervical manipulations; include both sexes; aged between 19 and 44 years	Participants must report no history of neurological disorders; must not report any episodes of acute dizziness; and must not present with severe visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-38y9xk6	Evaluation of a bioactive gel to control dental sensitivity in dental bleaching in adolescents	Not yet recruiting	Intervention	2025-06-12	<NULL>	<NULL>	8046	Evaluation of a bioactive gel to control dental sensitivity in dental bleaching in adolescents: double blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-24	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-38y9xk6	<NULL>	Good general and oral health (no need for surgery, endodontic, or periodontal treatment); both sexes; age between 12 and 16 years; at least six anterior upper teeth are free of active caries and endodontic treatment; if the anterior teeth have restorations, they must involve no more than 1/3 of the dental structure; canines (13, 23) must be A2 color or darker	Participants are undergoing orthodontic treatment; participants with dental prosthetics; severe tooth discoloration (such as tetracycline stains, fluorosis, or non-vital teeth)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-4shpqhj	Effect of Therapeutic Ultrasound on recovery after Elbow Fracture surgery	Not yet recruiting	Intervention	2025-04-24	<NULL>	<NULL>	8050	Additional effect of Therapeutic Ultrasound in postoperative rehabilitation of Elbow Fractures: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-16	Universidade Federal de Juiz de Fora	Programa de Pós Graduação em Saúde Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4shpqhj	<NULL>	Individuals aged 18 to 70 years; of both sexes; referred for physiotherapy treatment from the sixth week of surgical intervention after elbow fractures; with limited range of motion greater than or equal to twenty degrees of extension deficit; or less than or equal to one hundred and twenty degrees of elbow flexion; elbow fractures involving the distal segment of the humerus; proximal segment of the ulna; fracture of the neck and head of the radius according to Mason&apos;s Classification; elbow fractures and dislocations such as Hotchkiss&apos;s terrible triad; Monteggia lesion; transolecranon fracture and dislocation	Patients with bilateral elbow fractures or whose indicated treatment is total elbow arthroplasty; pregnant women; neurological, rheumatic or psychiatric diseases that compromise rehabilitation; previous history of elbow stiffness; previous surgical procedure on the elbow; existence of Kirschner wires or cerclage wires in the proximal ulna and distal humerus; Mini-Mental State Examination score of less than 24 points for those with higher education and 18 points with low to moderate level of education	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-88f3459	General versus regional Anesthesia complications	Not yet recruiting	Intervention	2025-06-15	<NULL>	<NULL>	8054	Impact of General versus Regional Anesthesia on the incidence of postoperative pulmonary complications in peripheral arterial surgery: a multicenter randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-07-15	Hospital de Clínicas de Porto Alegre	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-88f3459	<NULL>	Adult patients; men or women; American Society of Anesthesiologists classification II to IV;  aged &gt;18 years; scheduled for elective arterial revascularization surgery in the lower limbs	Patientes with a body mass index above 40 kg/m2;  those undergoing emergency surgery; with a history of lung surgery; persistent hemodynamic instability in the preoperative period; a history of asthma or chronic use of corticosteroid therapy; neuromuscular disorders; history of use of anticoagulants or antiplatelet agents in the preoperative period; other conditions that contraindicate spinal anesthesia will also be excluded from the study; patient refusal; infection at the puncture site for subarachnoid block; increased intracranial pressure; inability of the patient to cooperate due to agitation; cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-2rtpqt8	The use of Alpinia zerumbet gel-cream to manage pain and symptoms related to temporomandibular disorders	Not yet recruiting	Intervention	2025-06-17	<NULL>	<NULL>	8058	Clinical evaluation of the use of alpinia zerumbet gel-cream for use in patients with muscle temporomandibular dysfunction: randomized clinical study	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Sergipe	Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2rtpqt8	<NULL>	Individuals of both sexes; aged between 18 and 70 years; with at least 20 natural dental elements (10 on each side); diagnosed with muscular type temporomandibular disorders (TMD)	Individuals with any inability to answer questions asked during care; patients who are already using therapeutic ultrasound or another type of therapy for muscle fatigue	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-5x3tfq3	Effect of Water Exercise on the heart of postmenopausal women with high blood pressure	Not yet recruiting	Intervention	2025-06-19	<NULL>	<NULL>	8062	Cardiovascular effects of Aquatic Training in hypertensive postmenopausal women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-09	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Programa de Pós-Graduação em Ciências da Saúde da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5x3tfq3	<NULL>	Women; aged between 45 and 65 years; post-menopausal (1 year of permanent amenorrhea); who do not undergo hormone therapy; at most 6 years after menopause; hypertensive patients on medication; who have not practiced physical exercise regularly for at least three months, according to the response to physical activity practice obtained in the anamnesis; without musculoskeletal problems or cardiovascular complications that prevent the performance of physical exercise; must present a medical certificate proving that they are fit to practice physical exercise; have no history of stroke or acute myocardial infarction; are non-smokers and do not have a diagnosis of Diabetes Mellitus	Present any cardiovascular complications during collections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-68qv6wf	Adaptation, usability and initial results of a mindfulness program to support people in the search for meaning in life in a study with comparison groups	Not yet recruiting	Intervention	2025-06-25	<NULL>	<NULL>	8065	Adaptation, feasibility, and preliminary effectiveness of a Mindfulness-based program (Mindfulness-based health promotion - mbhp) for the search for meaning in life: a randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-68qv6wf	<NULL>	General population aged 18 years or older (based on the Mindfulness-Based Health Promotion - MBHP protocol)	a) Participants in the acute phase of depression; bipolar disorder; psychotic disorders, especially those with severe symptoms; b) Participants at risk of or with a history of dissociation, post-traumatic stress disorder, personality disorder, epilepsy, etc.; c) Participants using medications that cause cognitive impairment; d) Those with evident cognitive impairment; e) Those without access to high-speed internet for online videoconferencing (computer or smartphone); f) Those who are not available to attend 8 online sessions, each lasting 2 hours, and are unable to commit to completing the prescribed home practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-3yyd4jd	Comparison of the effects of the Invisalign Palatal Expander (IPE) and the Hyrax Expander in the treatment of narrow maxilla	Not yet recruiting	Intervention	2025-06-26	<NULL>	<NULL>	8069	Effects of treatment of Maxillary Atresia in the mixed dentition with the Invisalign Palatal Expander (IPE) system and Hyrax expander: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-3yyd4jd	<NULL>	Ages 7 to 10 years; both sexes; Angle Class I malocclusion; presence of maxillary atresia; erupted upper and lower permanent incisors	Patients with craniofacial deformities; dental agenesis; history of previous orthopedic/orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-10j6jt6x	Physiotherapeutic Follow-up of Patients with Chronic Low Back Pain: Multidimensional Assessment and Use of Data from an Extension Project	Not yet recruiting	Observational	2025-06-27	<NULL>	<NULL>	8072	Use of the Extension Project Database: Multidimensional Assessment and Physiotherapeutic Follow-up of Patients with Chronic Low Back Pain in the Management of Physical, Functional, and Psychosocial Sequelae	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Centro de Ciências Biológicas e da Saúde CCBS - Universidade Estadual do Oeste do Paraná	Centro de Ciências Biológicas e da Saúde CCBS - Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10j6jt6x	<NULL>	Volunteers with a clinical diagnosis of chronic low back pain; aged between 18 and 59 years; of both sexes; referred to the Physical Rehabilitation Center of the State University of Western Paraná (CRF-UNIOESTE), or by direct invitation	Individuals with acute low back pain; absence of safe hemodynamic conditions to perform the tests and worsening of chronic pain on the evaluation days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-2y8jkqb	THYRI Project: Two-plane uterine suture to decrease myometrial dehiscence in the cesarean site.	Not yet recruiting	Intervention	2025-06-28	<NULL>	<NULL>	8075	THYRI Project: Two-Plane Hysterorrhaphy to Reduce Isthmocele	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-15	Faculdade de Medicina de Jundiaí	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2y8jkqb	<NULL>	Pregnant woman submitted to the first cesarean section; pregnant woman submitted to lower-segment transverse cesarean section; woman with singleton pregnancy; no minimum or maximum age limit; feminine gender	Pregnant woman with myoma in the segment region of the uterus; woman submitted to emergency/urgent c-sections; woman with placenta previa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-8srwcqg	Implementation of a care program on falls prevention in older adults at high risk of falls	Not yet recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8079	Implementation of a case management-based intervention focused on falls prevention in older adults at high risk of falls: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-15	Centro de Ciências Biológicas e da Saúde	Centro de Ciências Biológicas e da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8srwcqg	<NULL>	Level of consciousness that allows the volunteer to be an active subject in the intervention; both genders; aged over 60 yeas; high risk of falls according to the global recommendation for the prevention and management of falls in older people (older people with a history of at least 1 fall in the last year and one or more of the following characteristics: injurious fall; ≥2 falls in the last year; presence of frailty syndrome; inability to get up after a fall without help for at least one hour; and fall accompanied by suspected transient loss of consciousness); ability to walk alone with or without a walking aid); and willingness to participate in the proposed assessments and interventions	Severe and uncorrected hearing and visual impairment that makes communication difficult during the intervention; presenting neurological diseases that rapidly modify the risk of falls (multiple sclerosis; diagnosis of moderate to advanced dementia; epilepsy; and traumatic brain injury; or taking associated medications); and presenting some contraindication to physical exercise (acute infectious disease; dissecting aortic aneurysm; severe aortic stenosis; congestive heart failure/unstable angina; acute myocardial infarction; acute myocarditis; acute pulmonary or systemic embolism; thrombophlebitis; ventricular tachycardia; and other dangerous arrhythmias)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-6hxvph7	Effects of green tea kombucha on health and physical performance	Not yet recruiting	Intervention	2025-07-01	<NULL>	<NULL>	8093	Green tea kombucha with grape peel phenolic extract: sensory evaluation and the acute and chronic effects on health and physical performance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-20	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Tecnologia de Alimentos da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-6hxvph7	<NULL>	Men and women; aged between 18 and 45 years; body mass index between 18.5 and 24.9 kg/m²; with low to moderate levels of physical activity, assessed by the International Physical Activity Questionnaire – short version (IPAQ)	Individuals with chronic diseases or disorders affecting the digestive, oral, hepatic, renal, cardiovascular, or thyroid systems; individuals with cancer; inflammatory diseases or eating disorders; those who have used anti-inflammatory drugs, corticosteroids, or antibiotics in the past three months; pregnant, breastfeeding, or menopausal women; individuals who use tobacco and/or drugs; those with alcohol consumption exceeding 21 units per week for men and 14 units per week for women; individuals undergoing nutritional counseling for muscle mass gain; those who use antioxidant nutritional supplements; individuals with present or recurrent musculoskeletal injuries; those who frequently consume Kombucha, other fermented foods, or green tea; individuals with an aversion to Kombucha	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-8y9z94y	EN23-0216-08_Evaluation of gynecological acceptance and pH balance, considering perceived effectiveness	Not yet recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8094	EN23-0216-08_Assessment of gynecological acceptability and pH maintenance with perceived efficacy	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2025-08-14	Medcin Instituto da Pele Ltda	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8y9z94y	<NULL>	Female population; female participants aged between 18 and 60 years; participants with an active sex life; participants with a vaginal pH value between 3.8 and 4.5; intact skin in the area of product application (vaginal mucosa); current user of products in the same category; willingness to follow the study procedures and attend the Clinical Research Center on the scheduled days and times for evaluations; understanding, agreement with, and signing of the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and/or lactation (for women); sexually transmitted infections, such as candidiasis, trichomoniasis, or conditions that compromise the safety evaluation of the product; use of anti-inflammatory drugs, immunosuppressants, or antihistamines up to 3 weeks before selection; skin markings in the experimental area that interfere with the evaluation of possible skin reactions, such as vascular malformations, scars, increased hair growth, numerous nevi, or sunburns; atopic or allergic history to products in the same category; active skin pathologies or lesions (local or disseminated) in the evaluation area; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or drug abuse; known or suspected intolerance to products in the same category; intense sun exposure up to 15 days before evaluation; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; other conditions deemed reasonable by the investigator for disqualification from participation in the study, which should be described in the clinical record observation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5nfpn48	Evaluation of hand strenght after Indirect Muscle Activation concomitant with a Mental Task, Laser Application and Pavilion Stimulation	Not yet recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8095	Evaluation of Handgrip strenght after Overflow of non-homologous muscles concomitant with Cognitive Dual Task, Laser and Auricular Stimulation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5nfpn48	<NULL>	Healthy individuals; both sexes; aged between 18 and 30; motor preference for the right upper limb	Participants will be excluded if they have orthopedic alterations, pain, difficulty in performing the palmar grip and index finger flexion movements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6rr5yq3	Effect of Lavandula angustifolia Essential Oil on the management of Facial Myalgia, Anxiety, and Bruxism	Not yet recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8097	Efficacy of Lavandula angustifolia Essential Oil in reducing signs and symptoms of Myofascial Pain, Bruxism, and Anxiety in children and adolescents: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-20	Programa de Pós-Graduação em Odontologia da Universidade Federal do Paraná	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-6rr5yq3	<NULL>	Participants of both sexes, regardless of race or ethnicity, aged between 5 and 17 years; with a diagnosis of myalgia or myofascial pain according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); and who present with related bruxism and anxiety	Participants who present with any cognitive impairment that prevents them from completing the questionnaires; whose guardians violate the study protocol, who demonstrate poor adherence to the treatment; or who provide information considered questionable by the investigators; children and adolescents with autoimmune diseases or syndromic conditions; those undergoing orthodontic treatment or those experiencing odontogenic pain; individuals using analgesic and/or anti-inflammatory medications within 48 hours prior to the start of the clinical assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9f3whw9	Phage therapy for the decolonization of specific multidrug resistant bacteria in high-risk patients	Not yet recruiting	Intervention	2025-07-04	<NULL>	<NULL>	8100	Building a decolonization model using phages against KPC producing Klebsiella pneumoniae in high risk patients: a prospective feasibility and proof of concept study	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9f3whw9	<NULL>	Patients of both genders; active hematological or oncological condition; use of immunosuppressive medications; history of infection by Klebsiella pneumoniae producing Klebsiella pneumoniae carbapenemase with high risk of recurrence; planned surgery with high risk of infectious complication; sufficient time window to administer at least 7 days of phage therapy; positive rectal swab for Klebsiella pneumoniae producing Klebsiella pneumoniae carbapenemase; availability of a combination of phages active against the patient’s isolate; age over 18 years; signed informed consent from the patient	Patients without informed consent signed; pregnancy; breastfeeding; hemodynamic instability; any other acute and severe organ dysfunction; antibiotic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-102g7f3m	Effects of ear Acupuncture on the Mental Health of college students: a clinical study	Not yet recruiting	Intervention	2025-07-09	<NULL>	<NULL>	8109	Auricular Acupuncture in the treatment of Emotional Disorders in university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-102g7f3m	<NULL>	Postgraduate strictu sensu students who present moderate or high levels of anxiety, stress, and/or depression according to the Depression, Anxiety, and Stress Scale (DASS-21); who agree to be randomly allocated to the study groups; of both genders; and who are 18 years of age or older	Ear piercings (except in the earlobe); history of allergy to metal or microporous tape; history of photosensitivity; injury, inflammation, deformity, or tattoos on the ear; history of skin cancer in the head and neck region; use of hearing aid; use of chemical peels (such as retinoic acid, retinol, Vitanol-A, tretinoin, isotretinoin) and/or Roaccutan® (Isotretinoin) up to six months prior to the start of treatment; individuals with compromised immune systems (e.g., undergoing cancer treatment or using immunosuppressive medications); epilepsy; use of a cardiac pacemaker; pregnant or breastfeeding women, or those planning to become pregnant during the study period; rejection of or fear of receiving the technique; and undergoing any other form of energy therapy concurrently with the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9tdngmz	Efficacy of Laser use in root canal treatment of deciduous teeth: a randomized clinical study	Not yet recruiting	Intervention	2025-07-09	<NULL>	<NULL>	8112	Efficacy of Photodynamic Therapy associated with potassium iodide in endodontic Treatment of Primary teeth: a ramdomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-20	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9tdngmz	<NULL>	Children of both genders; presenting at least one deciduous molar with a diagnosis of irreversible pulpitis or pulp necrosis; age between 5 and 9 years; with root resorption of a maximum of 1/3 of the roots; presence of the crypt of the permanent tooth and with sufficient dental structure to allow absolute isolation of the surgical field and subsequent restoration; children with positive behavior during the consultation	Children with any systemic alteration; history of allergic reaction to any medication; have used antibiotics in the last three months; systemic manifestation fever and extraoral abscess; negative behavior	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6m67nb9	Blood Flow Restricted Walking Training for patients with Lung Disease	Not yet recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8122	Effect of Walking Training combined with Blood Flow Restriction in patients with COPD and prolonged use of home Oxygen. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6m67nb9	<NULL>	Patients of both sexes; aged 50 years or older; presenting with Chronic Obstructive Pulmonary Disease (COPD); using home oxygen; with an Modified Medical Research Council Scale  (mMRC) score between 1-3; who have clinically tested positive for at least two weeks; Review the Informed Consent Form	orthopedic or cognitive conditions that prevent them from performing functional capacity tests; , pulmonary embolism, stroke, acute myocardial failure, peripheral arterial disease; smokers; using beta-blocker medications; undergoing another form of non-drug treatment; patients who cannot tolerate the exercise session;exacerbation in the last two weeks; those who refuse to sign the Free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5cgpv4t	Auditory Brainstem Response (ABR)) hearing test in children with speech delay: comparison between Inhalation and Intravenous Anesthesia	Not yet recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8123	Auditory Brainstem Response (ABR) in children with language delay: comparison between Inhalation and Intravenous Anesthesia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2026-02-25	Faculdade de Medicina da Universidade de São Paulo	Instituto de Pesquisa e Ensino em Saúde Infantil (PENSI)	https://ensaiosclinicos.gov.br/rg/RBR-5cgpv4t	<NULL>	Children under investigation for language delay or suspected autism spectrum disorder, or undergoing audiological monitoring, who are scheduled to undergo an auditory brainstem response under general anesthesia must present: transient otoacoustic emissions with at least four reproducible responses; distortion product otoacoustic emissions with at least four reproducible responses; and auditory brainstem responses demonstrating waves I, III, and V elicited by a click stimulus at 80 decibels	Suspected or confirmed genetic syndromes; american society of anesthesiologists physical status classification of three or higher; patients with middle ear pathology; non-portuguese speakers; clinical history of neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:09
RBR-85tkdz5	Sacred Dances versus physical training on Heart Failure	Not yet recruiting	Intervention	2025-07-15	<NULL>	<NULL>	8130	Effects of sacred dances versus physical training on Heart Failure a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-05	Fundação Bahiana para o Desenvolvimento da Ciência	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-85tkdz5	<NULL>	Women; ages 18 to 70; Heart Failure Class I, II or III according to the New York Heart Association; no regular physical exercise for 3 months; ability to perform moderate physical activities	Clinical conditions of any nature that prevent the performance of physical activities; chronic kidney disease requiring dialysis; oxygen desaturation during exercise; complex ventricular arrhythmias at rest or during exercise; hospitalization due to cardiovascular decompensation, acute myocardial infarction, surgical or percutaneous revascularization, complex arrhythmias or sudden reversed death; social incapacity to attend the proposed sessions; serious cognitive or psychiatric problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-8hqz6s6	Evaluation of the use of removal solution in the prevention of Injuries caused by medical adhesives	Not yet recruiting	Intervention	2025-07-15	<NULL>	<NULL>	8132	Effect of removal rolution in preventing the occurrence of medical adhesive-related Injuries (MARSI): randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-05	Hospital das Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8hqz6s6	<NULL>	Individuals of both sexes; aged 18 years or older; who have undergone compression dressings with medical adhesives following endovascular procedures; elective or emergency procedures; hospitalized after the procedure	Presence of previous skin lesions or lesions adjacent to the area where the compressive dressing will be applied	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-32by67h	Lifestyle and mental health in adolescents	Not yet recruiting	Intervention	2025-07-17	<NULL>	<NULL>	8136	An experimental study between lifestyle and mental health in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-32by67h	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; food intolerance to some food; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-46kgpmz	Use of Vibration Platform to increase muscle strength and improve performance in amateur street runners	Not yet recruiting	Intervention	2025-07-19	<NULL>	<NULL>	8139	Whole Body Vibration in the response of muscle strength and performance in amateur street running athletes: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Centro Universitário Augusto Motta - UNISUAM	Centro Universitário Augusto Motta - UNISUAM	https://ensaiosclinicos.gov.br/rg/RBR-46kgpmz	<NULL>	Amateur street runners; aged between 18 and 59; of both genders	Recent surgeries; prosthetic surgeries; osteoporosis; uncontrolled hypertension; metal prosthesis;recurrence of osteosynthesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-102fn4kd	The effect of Strength Exercise with Blood Flow Restriction using different Pressure Levels in the elderly	Not yet recruiting	Intervention	2025-07-21	<NULL>	<NULL>	8143	Physiological marker responses to Resistance Exercise with Blood Flow Restriction using different Occlusion Pressures in older adults	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Felipe Corbellini	Universidade Comunitária da Região de Chapecó - Unochapecó	https://ensaiosclinicos.gov.br/rg/RBR-102fn4kd	<NULL>	The study will include elderly individuals aged 60 to 70 years old; of both genders; and who do not have a routine of systematic physical exercise.	Individuals with severe arterial and/or venous insufficiency (assessed by VLab-4000); joint or mobility problems that prevent and/or limit the performance of the exercises predetermined by the protocol; and endocrine dysfunctions related to the biomarkers analyzed in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-8gbnr2x	Healthy volunteer study to test the safety of an antibiotic combination	Not yet recruiting	Intervention	2025-07-21	<NULL>	<NULL>	8144	A phase I, randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and pharmacokinetics of Pitavastatin+Polymyxin B (Pva+Pmx), Desloratadine+Meropenem (Des+Mpm), and Ceftibuten+Polymyxin B (Cef+Pmx) in healthy adults	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Evangélica de Goiás	Universidade Evangélica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8gbnr2x	<NULL>	Healthy adult men and women of non-childbearing potential. aged 18 to 55 years. Body mass index between 18.5 kilograms per square meter and 29.9 kilograms per square meter and body weight between 55.0 kilograms and 100.0 kilograms. No clinically significant abnormalities at screening or on Day 1, including vital signs within normal parameters (temperature, Normal heart rate, respiratory rate, and blood pressure), Normal electrocardiograms, hemoglobin/hematocrit, white blood cell count and platelet count greater than or equal to the lower limit of normal, serum creatinine less than 1.4 milligrams per deciliter, serum urea nitrogen less than 40 milligrams per deciliter, alanine aminotransferase and aspartate aminotransferase less than 50 units per liter	History or presence of significant cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, or neurologic disease that may increase the risk of adverse effects from study medications. History of confirmed or suspected Clostridium difficile infection. History of seizure disorders. Positive urine drug or alcohol test during screening. Positive test for human immunodeficiency virus (HIV), Positive test for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV). History of substance or alcohol abuse that increases the risk of adverse effects from study medications. Use of any prescription or over-the-counter medication; use of herbal products; use of vitamins; use of dietary supplements or hormonal supplements in the seven days prior to randomization. Documented hypersensitivity or anaphylaxis to any medication. Donation of blood or plasma in the thirty days prior to randomization, total blood loss greater than 500 milliliters in the thirty days prior to randomization, or blood transfusion in the one year prior to study enrollment. Participation in a clinical trial involving a New Chemical Entity in the last three months or a marketed drug in the thirty days prior to the first dose of the study drug. Any other condition or prior therapy that would make the volunteer unsuitable for the study, inability to fully comply with the study protocol or likely non-compliance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-3qmg5nj	Assessment of distal temperature before and after the use of positive airway pressure in patients with sleep apnea according to preferred times for sleeping and waking up	Not yet recruiting	Intervention	2025-07-22	<NULL>	<NULL>	8149	Assessment of distal temperature before and after the use of Positive Airway Pressure device in patients with Obstructive Sleep Apnea according to chronotype	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-30	Faculdade de Saúde Pública da Universidade de São Paulo	Departamento de Saúde e Sociedade da Faculdade de Saúde Pública da Universidade de São Paulo FSP/USP	https://ensaiosclinicos.gov.br/rg/RBR-3qmg5nj	<NULL>	Patients of both sexes;aged18 years or older; with a diagnosis of moderate or severe obstructive sleep apnea; who are beginning the adaptation process to Positive Airway Pressure (CPAP) with a nasal mask indication, will be recruited	Patients presenting with other sleep disorders as insomnia; parasomnias; narcolepsy; central sleep apnea; uncontrolled clinical disease as diabetes; renal or cardiac failure; recent stroke or coronary insufficiency; recent postoperative period; Chronic obstructive pulmonary disease; oxygen dependence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-8dyvkz7	Multimodal Preemptive Analgesia in third molar surgery, a randomized clinical trial	Not yet recruiting	Intervention	2025-07-25	<NULL>	<NULL>	8157	Evaluation of the efficacy of Multimodal Preemptive Analgesia with Nimesulide and Tramadol Hydrochloride versus Dexamethasone in controlling pain, edema and trismus after extraction of lower third molars	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-8dyvkz7	<NULL>	Patients over 18 years of age; both sexes; without general health impairment according to medical history and physical examination; patients with indication for extraction of bilateral mandibular third molars; impacted; asymptomatic; in class IIB position, according to the Pell &amp; Gregory classification; with similar surgical difficulty	Patients with a history of hypersensitivity to any of the components of the medications used; patients who have used anti-inflammatory drugs in the 15 days prior to surgery; patients with tuberculosis, leukocytosis, collagen vascular diseases, multiple sclerosis, HIV infection, and other autoimmune diseases; pregnant and lactating patients; patients with a history of pericoronitis; patients with cognitive disorders that make it impossible to understand and execute commands; patients who withdraw consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-8d9fhcn	Spinal Manipulation vs. Mobilization: Which Is More Pleasurable? A Randomized Crossover Study	Not yet recruiting	Intervention	2025-07-25	<NULL>	<NULL>	8158	Is Spinal Manipulation more pleasurable than Mobilization? Randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-17	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8d9fhcn	<NULL>	Healthy individuals of both sexes; aged 18 to 40 years; no significant low back pain in the past 3 months	Individuals with a history of recent trauma to the lumbar spine or other spinal regions; neurological impairment; osteoporosis; history of spinal surgery; history of spinal fractures; the presence of chronic or acute musculoskeletal injuries in the spine; use of corticosteroids in the past month and analgesics in the two days before the intervention; sensory alteration; having received spinal manipulation or mobilization in the five days preceding the interventions; pregnancy; history of autoimmune disease (ankylosing spondylitis, rheumatoid arthritis, or others); spinal inflammation; spinal tumor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-2bzxr22	Use of Laser and Antimicrobial Dressing in the treatment of foot wounds in people with Diabetes	Not yet recruiting	Intervention	2025-07-29	<NULL>	<NULL>	8161	Photodynamic Therapy Alone, DACC, and their combination in the treatment of foot Ulcers in people with Diabetes: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-30	Hospital Universitário do Oeste do Paraná	Hospital Universitário do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2bzxr22	<NULL>	Individuals aged 18 years or older (men and women); who have 1 or more infected ulcers on the foot, present for at least 2 months and a maximum of 24 months, ulcer size from 1 to 100 cm2; who have an ankle-brachial pressure index greater than or equal to 0.80	Patients with known hypersensitivities or allergies to the dressing materials used in the study; patients undergoing recent or active cancer treatment; patients with severe malnutrition; patients with ulcers diagnosed as malignant; patients with systemic infection treated with continuous antibiotics (local and/or systemic antibiotics) for more than 5 consecutive days and in the last 5 days prior to treatment; patients who have used corticosteroids (local or systemic) in the 5 days prior to treatment; uncontrolled diabetes with glycated hemoglobin: Hb A1c greater than or equal to 10; chronic diseases that impair wound healing: autoimmune disorder in an acute flare-up phase, chronic kidney disease, and peripheral vascular insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-4msv7mh	Effect of Laser therapy on pain in lactating postpartum women with nipple Fissures	Not yet recruiting	Intervention	2025-07-31	<NULL>	<NULL>	8173	Effectiveness of a protocol using Photobiomodulation therapy on pain in lactating postpartum women with nipple Fissures: a randomized, controlled, double-blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Alfenas UNIFAL-MG	Universidade Federal de Alfenas UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-4msv7mh	<NULL>	Postpartum women over 18 years of age; with nipple fissure secondary to breastfeeding; with pain graded at least two by the NDT; with the ability to understand and answer questions	Women who refused to undergo the intervention; those using other substances on the nipple, such as ointments; presence of a systemic or local infectious process; presence of underlying diseases that make therapy difficult or impossible, such as diabetes mellitus; cancer; neurological diseases; cognitive alterations; pregnancy and photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-95jnbpt	Efficacy of In-office Bleaching immediately and 72 hours after its manipulation	Not yet recruiting	Intervention	2025-07-31	<NULL>	<NULL>	8177	Efficacy of In-office Bleaching with Attachable Syringe: immediate and after 72 hours of mixing: randomized, triple-blind equivalence clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-95jnbpt	<NULL>	Volunteers aged at least 18 years; both sexes; with good general and oral health; with teeth free of caries and periodontal disease in the anterior region; who agree to the free and informed consent form and whose canines must have A2 color or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Volunteers who have previously undergone a whitening procedure; who have reported the presence of previous dental sensitivity; presence of dental prosthesis; fixed orthodontic appliance; restorations in the upper anterior teeth; endodontic treatment in the upper anterior teeth; gingival recessions; teeth with tetracycline staining or fluorosis; continuous use of medications such as analgesics and anti-inflammatories; pregnant or lactating women and those with habits such as bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-10kxvwb2	The effect of technologies that care and educate on the resilience of adolescent students at social risk	Not yet recruiting	Intervention	2025-08-01	<NULL>	<NULL>	8180	Effect of Care-Educational Technologies on the Resilience of School Adolescents in Situations of Social Vulnerability: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-20	Departamento de Enfermagem da Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10kxvwb2	<NULL>	Participants of both sexes; aged between 16 and 19 years; belonging to state schools located in communities with high levels of social vulnerability and/or low Basic Education Development Index; belonging to the Recife Sul Regional School Management	Participants with a previous medical diagnosis of special educational needs presented to the school administration that may compromise their participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-3wqx6b6	Non-invasive brain stimulation for the treatment of symptoms of Anxiety and Depression in patients with Endometriosis	Not yet recruiting	Intervention	2025-08-01	<NULL>	<NULL>	8181	Transcranial Direct Current Stimulation for the treatment of Anxiety and depressive symptoms in individuals with Endometriosis: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-30	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3wqx6b6	<NULL>	Women; age between 18 and 40 years; diagnosis of Endometriosis identified by imaging exams and the presence of clinical findings; cognitive ability to understand and answer questionnaires; tolerance to treatment with electrical stimulation; symptoms of Anxiety identified by the Hamilton Anxiety Scale; depressive symptoms identified above 16 on the Center for Epidemiological Studies – Depression Scale	Being in the puerperal period (up to 12 months postpartum); currently breastfeeding; history of brain surgery, tumors, dizziness, or epileptic disease; history of alcohol or drug abuse; having metallic implants in the head; complaint of severe headache, dizziness, or severe migraine within 6 hours after the application in more than two sessions of Transcranial Direct Current Stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-7v3rgrt	Evaluation of the Sede-E protocol in practice: clinical study conducted in multiple hospitals with randomized participants	Not yet recruiting	Intervention	2025-08-07	<NULL>	<NULL>	8190	Clinical evaluation of the use of the Sede-E protocol: multicenter randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual de Londrina	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-7v3rgrt	<NULL>	Patients admitted to the Intensive Care Unit (ICU); within one hour of extubation; not using non-invasive ventilation at the time of assessment; age 18 or older; both sexes; thirsty	Need for reintubation; post-operative head and neck surgery; dysphagia prior to intubation; and contraindication to elevating the head of the bed by 30 to 45º	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-4njwqsw	Efficacy of a New Device to prevent Cervical Narrowing after Conization	Not yet recruiting	Intervention	2025-08-08	<NULL>	<NULL>	8193	Efficacy of an Intracervical Device (ICD) in preventing Cervical Stenosis following Type III Excisional Procedure (Conization) of the uterine cervix	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2025-09-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4njwqsw	<NULL>	Women indicated for type III excision (conization) of the uterine cervix; women aged 25 and older	Women with any history of previous excisional procedures (regardless of type or timing); pregnant women; women who become pregnant within 90 days following the excisional procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-9cnvv46	Effects of Virtual Reality on children and young people with sensory and motor problems	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8194	Effects of an intervention protocol using Virtual Reality in children and young people with sensory-motor changes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	https://ensaiosclinicos.gov.br/rg/RBR-9cnvv46	<NULL>	Children and young people with sensorimotor disorders; will be included in the study; of both sexes; aged from 10 years to 17 years 11 months and 29 days	Participants unable to understand will be excluded; execute intervention-specific instructions and commands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-6735k46	Effect of functional training on postural control and gait in older adults during associated tasks	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8196	Effect of 12 weeks of functional training on postural control and locomotor pattern in dual task stair ascent and descent in older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6735k46	<NULL>	Healthy elderly; men and women; age between 60 and 80 years; preserved cognitive function; independent walking;	Neurological conditions that prevent the performance of experimental tasks; musculoskeletal conditions that prevent the performance of experimental tasks; vestibular conditions that prevent them from performing experimental tasks; health conditions that significantly compromise balance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-3vjv574	Evaluation of the effectiveness of using cosmetics for skin care in cancer patients	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8198	Evaluation of the use of cosmetics for skin care in cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de São João del-Rei	Hospital São João de Deus Fundação Geraldo Corrêa	https://ensaiosclinicos.gov.br/rg/RBR-3vjv574	<NULL>	Women; aged between 18 and 59 years; taking oral capecitabine (Xeloda®); who agree to participate in the study after reading the Informed Consent Form (FICF); who present a medical referral for participation in the proposed protocol; who do not report previous allergic reactions to cosmetics; who present mental conditions suitable for participation in the study, as assessed using the Mini Mental Scale	Patients diagnosed with breast cancer who do not use oral capecitabine (Xeloda®); Clinical condition that makes it unsafe to participate in a group setting (e.g., severe neutropenia); Report allergy to the use of cosmetics; Patients who use capecitabine (Xeloda®) concomitantly with radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2j24fkk	Effectiveness of Arginine supplementation in aiding the treatment of Sickle Cell Anemia	Not yet recruiting	Intervention	2025-08-12	<NULL>	<NULL>	8204	Randomized double-blind placebo controlled clinical trial to study the efficacy of L-arginine: adjuvant therapeutic protocol in the treatment of Sickle Cell Anemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Secretaria da Saude do Estado do Ceara	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2j24fkk	<NULL>	Adult patients with Sickle Cell Anemia; age 18 or over; of both sexes; taking hydroxyurea (dose equal to or greater than 500mg/day)	Patients who have undergone transfusion therapy in the last three months; patients using iron chelators or antioxidant vitamins; smokers; alcoholics; pregnant women; with Diabetes mellitus; renal and/or hepatic insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-4nqkkvk	Study on the use of high and low power lasers in the treatment of temporomandibular joint disorders	Not yet recruiting	Intervention	2025-08-19	<NULL>	<NULL>	8216	Comparison of high and low power diode laser in the therapeutic treatment of patients with Temporomandibular Dysfunction (TMD): a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Pontificia Universidad Catolica Madre y Maestra	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4nqkkvk	<NULL>	Patients over 18 years of age, Both genders male and female, Patients included in the Research Diagnostic Criteria for temporomandibular joint disorders (RDC/TMD); Patients with pain and symptomatology in the temporomandibular, orofacial and craniocervical regions; patients with or without limitation of jaw movements, opening and laterals; patients with or without presence of noise in the Temporomandibular Joint	Patients with congenital conditions and neoplastic conditions involving alterations in the temporomandibular joint and in orofacial and craniocervical regions; Patients with a history of recent trauma in the orofacial and craniocervical region; Patients with current use of myorelaxant plates for the treatment of temporomandibular disorders; Patients with functional orthopedic appliances or fixed or removable orthodontic appliances; Patients with cleft lip or palate; Patients with psychiatric disorders; Patients with severe cardiovascular problems; Patients with severely precarious oral and dental conditions such as periodontitis and in need of endodontic treatment; Patients using topical or systemic photo-sensitizing medications; Patients with dermatological diseases in the orofacial and craniocervical region; Pregnant women; Patients with severe oral and dental conditions such as periodontitis and in need of endodontic treatment; Patients who use topical or systemic photo-sensitizing medications; Patients with dermatological diseases in the orofacial and craniocervical region; Women in a state of pregnancy; Patients who use topical or systemic photo-sensitizing medications; Patients who are in need of endodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-2qcddnp	Analysis of the incidence, severity and temporal evolution of motion sickness after using the C-95M Flight Simulator	Not yet recruiting	Intervention	2025-08-22	<NULL>	<NULL>	8224	Analysis of the incidence, severity and temporal evolution of Simulator Sickness after exposure to the C-95M flight trainer: an exploratory experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-25	Comando da Aeronáutica	Base Aérea de Natal	https://ensaiosclinicos.gov.br/rg/RBR-2qcddnp	<NULL>	Healthy volunteers; both genders; trainee pilots of the transport aviation of the Natal Air Base	Be medically exempt from aerial activity or simulator training for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-48qqsq2	Does Mental Fatigue caused by the use of social networks impair visual-motor skills of beach volleyball players? A randomized crossover study	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	8225	Does Mental Fatigue caused by the use of social networks impair percepto-cognitive abilities of beach volleyball athletes? A randomized crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-10	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba - CCS/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-48qqsq2	<NULL>	Have been training beach volleyball for at least one year; have experience in official competitions; be training regularly for competitions; have not been diagnosed with neurological diseases; be between 15 and 21 years old; be male or female	Withdraw from participating for any reason; and/or suffer any type of injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-9kfnshy	Effects of a Conventional Cardiovascular Rehabilitation protocol compared to the use of Game therapy in participants with type 2 Diabetes	Not yet recruiting	Intervention	2025-08-28	<NULL>	<NULL>	8238	Effects of a Conventional Cardiovascular Rehabilitation protocol versus adapted to Virtual Reality in participants with type 2 Diabetes: Controlled and randomized study protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9kfnshy	<NULL>	Individuals age eighteen and over; both genders; without Pulmonary diseases and Peripheral arterial obstructive disease; those who undergo regular monitoring by an angiologist and endocrinologist; residents in the city of Natal / RN; who are not enrolled or have participated in the last six months prior to the study in any Cardiovascular rehabilitation program	Individuals with acute or uncontrolled Congestive heart failure; individuals with unstable or uncontrolled Angina; individuals with uncontrolled Cardiac arrhythmia causing hemodynamic symptoms; subjects with severe symptomatic Aortic stenosis; individuals with Deep venous thrombosis; individuals with recent Pulmonary embolism; individuals with Pericarditis or Acute myocarditis; individuals with Dissected aneurysms (known or suspected); individuals with unstable or uncontrolled Blood pressure (systolic pressure greater than one hundred sixty millimeters of mercury and diastolic pressure greater than one hundred millimeters of mercury); individuals with Acute systemic infection or uncontrolled Diabetes; individuals with limitations due to Musculoskeletal diseases or Cognitive difficulty in understanding activities; individuals who present Sweating and/or Dizziness during the evaluation and/or exercise Protocol, peripheral oxygen desaturation during the Step test below ninety percent; individuals who drop out or miss two consecutive Training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-5c7z52w	Study on two types of Intrauterine Devices - IUD for protection of the uterus in women in menopause	Not yet recruiting	Intervention	2025-08-29	<NULL>	<NULL>	8240	Randomized clinical trial with two different types of Levonorgestrel IUD for endometrial protection in women using Estradiol hormone therapy for vasomotor symptoms during menopause	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2025-09-10	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-5c7z52w	<NULL>	Postmenopausal patients or  those transitioning to menopause; aged 48 or over; with Follicle-Stimulating Hormone FSH dosage greater than or equal to 25; with indication for hormonal therapy; who have a uterus; no contraindications to the use of Intrauterine Devices; with a mammogram no more than 1 year ago classified as Breast Imaging Reporting and Data System (BIRADS) 1/2 or 3	Previous use of Hormone Therapy; refusal to participate in the study; Endometrial line greater than or equal to 5 mm in women with more than one year since the last menstruation (post-menopause); abnormal uterine bleeding of structural cause (polyp, leiomyoma, adenomyosis, suspected endometrial malignant neoplasm) in women in the menopausal transition; contraindications to the use of Hormone Therapy (breast cancer, endometrial cancer, hormone-dependent ovarian cancer, history of stroke, history of ischemic heart disease, active liver disease, thrombosis, or acquired or hereditary thrombophilia, porphyria, meningioma); uterine malformations, intracavitary changes of the uterus; patient under investigation for hormone-dependent neoplasia or precursor lesion during the study follow-up; personal history of thromboembolism or diagnosis of thrombophilia; personal history of angina, stroke or myocardial infarction; active liver disease; hypersensitivity to the components of the medications used in the study; porphyria; neurological or psychiatric diseases that make it impossible to follow the study instructions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-9xt9t5r	Do Abdominal Exercises help close muscle separations after childbirth?	Not yet recruiting	Intervention	2025-08-29	<NULL>	<NULL>	8241	Can Core Training reduce the inter-rectic distance in postpartum women with diastasis? randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9xt9t5r	<NULL>	The study will include women over 18 years of age with diastasis recti abdominis. Those with a distance of 2.8 cm between the muscle bellies at rest or 2.5 cm during flexion will be considered eligible. Furthermore, all volunteers with visible abdominal bulging on ultrasound will be included, regardless of the inter-rectus distance. Participants must be between 6 and 24 months postpartum, have no history of abdominal plastic surgery or umbilical hernia repair, have no abdominal wall hernia, have no low back pain, and are not pregnant. They must also not participate in other resistance exercise programs	Participants who, during training, become pregnant or develop any clinical condition that poses a health risk and compromises continued participation in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-5r67whx	Premature ovarian insufficiency associated with hypertension and cardiovascular effects - hormonal replacement therapy and physical training as treatments	Not yet recruiting	Intervention	2025-09-01	<NULL>	<NULL>	8244	Premature Ovarian Insufficiency associated with hypertension and hemodynamic, autonomic, morphological and cardiac functional effects - Hormonal Replacement Therapy and Physical Training as countermeasures	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo - FMRP/USP	Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-5r67whx	<NULL>	The study included normotensive and hypertensive women in two different age groups: 25 to 45 years old, and 55 to 65 years old. The younger group included women with preserved ovarian function, as well as women with premature ovarian failure who had undergone hormone replacement therapy for at least two years. The older group included women who had undergone physiological menopause, as well as women with premature ovarian failure who had undergone hormone replacement therapy until the age of physiological menopause (around 51 years).	Volunteers presenting any of the following conditions will not be included in the study: uncontrolled hypertension,  cognitive impairment preventing understanding of the tests and aerobic physical training, musculoskeletal changes preventing physical training, endocrine, metabolic and cardiovascular diseases, such as coronary artery disease and arrhythmias Smokers, individuals using drugs that interfere with cardiac function and cardiovascular autonomic control (e.g. beta-adrenergic blockers), and those using hormone replacement therapy will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-5wnttvg	The role of physical exercise in brain health the body and well being in adults	Not yet recruiting	Intervention	2025-09-02	<NULL>	<NULL>	8249	Analysis of Cognitive Cardiovascular and Metabolic parameters and quality of life in adults practicing physical exercise in the community	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-15	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5wnttvg	<NULL>	this study will include adults over the age of 18 who are part of the jequié ativo program or who want to participate of their own free will in a physical exercise program in the community	pregnant women; those with severe heart disease and those with persistent hypertension will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-82fp2rx	Effect of laser treatment on the major salivary glands of patients with Hypertension and Diabetes who have dry mouth and low saliva production and its impact on quality of life	Not yet recruiting	Intervention	2025-09-02	<NULL>	<NULL>	8250	Effect of Photobiomodulation on major salivary glands of Hypertensive and Diabetic patients with Hyposalivation and Xerostomia and its impact on quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-10	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-82fp2rx	<NULL>	Patients over 18 years of age; hypertensive patients taking antihypertensive medications; type 2 diabetics will be included	Patients undergoing cancer treatment; patients with Sjögren&apos;s Syndrome; those with renal failure; type 1 diabetics;pregnant women; breastfeeding women; patients using anxiolytics which have xerostomia and hyposalivation as a side effect; those who present any type of photosensitivity will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-10m89r69	Exercises to improve Back Pain in elderly people treated in public health services	Not yet recruiting	Intervention	2025-09-08	<NULL>	<NULL>	8263	Effectiveness of an Exercise Program for elderly people with Chronic Low Back Pain treated in Primary Health Care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal de Juiz de Fora - UFJF	Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-10m89r69	<NULL>	Aged 60 years or older; both sexes; report chronic low back pain, defined as the presence of symptoms in the lumbar region for a period longer than three months; present a score of four or higher on the Roland-Morris Disability Questionnaire and pain intensity greater than three on the Visual Analog Scale (VAS)	Individuals presenting with radiculopathies; severe spinal pathologies such as cauda equina syndrome, fractures, or cancer; history of spinal surgery within the past 12 months; signs of cognitive impairment; pregnancy; or absolute and relative contraindications to exercise, as described in the guidelines of the American College of Sports Medicine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-722vgv8	Comics for health education of schoolchildren	Not yet recruiting	Intervention	2024-08-08	<NULL>	<NULL>	8271	Construction and validation of a comic book for health education for schoolchildren	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-08-02	Programa de Pós-Graduação em Saúde Coletiva da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-722vgv8	<NULL>	School children enrolled in the 2nd to 5th grade of elementary school; aged between 7 and 10 years old; both genders	School children who have any limitation that prevents participation in intervention activities; or any severe metabolic alteration that requires the use of medications or specific dietary treatment that alters metabolism. In the event of the development of any of the exclusion criteria during the study, the child will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9f5f4yr	Transcranial Direct Current Stimulation associated with ReST for speech disorders: a randomized clinical trial	Not yet recruiting	Intervention	2025-09-15	<NULL>	<NULL>	8281	Transcranial Direct Current Stimulation associated with the ReST Method on the Treatment of Motor Speech Disorders: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-15	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-9f5f4yr	<NULL>	Study 1: Children of both sexes; ages 5 to 12 years and 11 months; speech-language pathology diagnosis of Motor Speech Delay, Childhood Apraxia of Speech, Developmental Dysarthria, or Childhood Apraxia of Speech associated with Developmental Dysarthria. Study 2: Adults of both sexes; ages 18 and older; speech-language pathology diagnosis of Apraxia or Dysarthria	Study 1: neurological diagnosis that constitutes the etiological cause of speech motor alterations such as cerebral palsy, syndromes, intellectual disability; craniofacial anomalies such as cleft lip and palate; metal implants in the skull; brain diseases such as tumors; skin diseases; failure in hearing screening performed with Transient Evoked Otoacoustic Emissions; concomitant speech-language pathology intervention; previous application of Transcranial Direct Current Stimulation. Study 2: oral comprehension deficits; failure in hearing screening performed with Transient Evoked Otoacoustic Emissions; craniofacial deformity reported or observed during the evaluation; neurological and/or psychiatric disease other than stroke; concomitant speech-language pathology intervention; previous application of Transcranial Direct Current Stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9b43r9r	The effect of an intervention on common mental disorders with community health agents	Not yet recruiting	Intervention	2025-09-16	<NULL>	<NULL>	8283	Effectiveness of an intervention on common mental disorders with community health workers: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-04-05	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-9b43r9r	<NULL>	Community Health Agents, regardless of age or gender, who are affiliated with the Municipal Health Department of Uberaba and have been in professional practice for at least 12 months will be included.	Community Health Agents who are on vacation or sick leave during the development of the research will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-37fpj5d	Efficacy of Cerebellar Neuromodulation on balance in active community-dwelling elderly people	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8294	Efficacy of Cerebellar Repetitive Transcranial Magnetic Stimulation on postural balance in active community-dwelling elderly people	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-15	Centro de Ciências da Saúde da Universidade Federal do Espirito Santo	Programa de Pós-Graduação em Ciências Fisiológicas da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-37fpj5d	<NULL>	Community-dwelling elderly; both genders; aged over 60; independent mobility; preserved bipedal stance; preserved walking ability	Neuropsychiatric crises; history of seizures; use of a cardiac pacemaker; use of ocular prosthesis; presence of a metal clip in the head; presentation of unstable vital signs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2mk8398	Ozone Therapy for the management of Oral Mucositis associated with cancer treatments	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8298	Evaluation of Ozone Therapy in the control of Oral Mucositis induced by antineoplastic therapies: randomized clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Estadual do Oeste do Paraná	Hospital do Câncer Uopeccan	https://ensaiosclinicos.gov.br/rg/RBR-2mk8398	<NULL>	Patients aged 18 years or older. Patients of both sexes. Patients with confirmed diagnosis of malignant neoplasm in the oral cavity. Patients undergoing chemotherapy or radiotherapy at the Uopeccan Cancer Hospital. Patients presenting with oral mucositis grade I to III according to the World Health Organization (WHO) classification. Patients using standard medications for mucositis management according to the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) guidelines. Patients who provide informed consent	Patients with malignant neoplasm in the hypopharynx, salivary glands, or lips. Patients with mucositis extending to the oropharynx or esophagus. Patients undergoing concomitant alternative therapies, such as biological agents or cryotherapy. Patients with severe comorbidities. Patients using medications not included in the guidelines of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Patients undergoing antineoplastic treatment not exclusively at the Uopeccan Cancer Hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-633mkf7	Best Pain Block with Ultrasound in kids: comparing techniques for Abdominal Surgeries	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8299	Comparative study between Ultrasound-Guided Quadratus Lumborum Blocks, TAP Blocks, and Sacral Epidural Anesthesia in pediatric patients undergoign Abdominal Wall Surgery: a randomized double-blind study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-10-01	Hospital São Domingos	Hospital Infantil Dr. Juvêncio Matos	https://ensaiosclinicos.gov.br/rg/RBR-633mkf7	<NULL>	Pediatric patients undergoing elective unilateral or bilateral abdominal wall surgery; both genders; age between 1 and 8 years; American Society of Anesthesiologists (ASA) physical status classification I or II	Pediatric patients presenting American Society of Anesthesiologists (ASA) physical status classification III or IV; skin redness or infection at the needle injection site; diagnosis of coagulopathy; liver disease; motor developmental delay; known allergy to local anesthetics; parental refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-5g6rk3h	Evaluation of Pregabalin as preemptive analgesia in postoperative pain in orthopedic foot and ankle surgery: randomized clinical trial	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8301	Use of Pregabalin as preemptive analgesia in orthopedic foot and ankle surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-09-30	Centro Universitário CESMAC	Centro Universitário CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-5g6rk3h	<NULL>	Patients with surgical indications; originating from elective and emergency orthopedic clinics at Santa Casa de Misericórdia de Maceió; over 18 years of age; of both sexes	Patients with neuropathy of any etiology; history of abusive use or addiction to analgesics and opioids; history of allergy or intolerance to the use of Pregabalin; history of chronic use of Pregabalin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-426p272	How to prevent Tooth Decay and Mouth Sores during Cancer treatment: the role of public universities in health and education	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8303	Prevention of Radiation Caries and Oral Mucositis in Cancer Patients: the transformative role of public universities in promoting health and education	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-31	Faculdade de Odontologia de Araraquara da Universidade Estadual Paulista (UNESP)	Santa Casa de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-426p272	<NULL>	Adults (aged 18 years or older); diagnosis of cancer in the head and neck region; indication for radiotherapy in this region, scheduled to begin within 20 days after recruitment, with or without concomitant chemotherapy; ability to understand and communicate in order to respond to questionnaires and adhere to the protocol; signed informed consent form (ICF).	History of previous radiotherapy in the head and neck region; allergy to any of the components of the products to be provided; participants with severe systemic complications, decompensated and unfit to receive the preventive protocols during treatment (e.g., degenerative neurological diseases, terminal conditions); completely edentulous participants; pregnant or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-2x5w7rf	Horizontal Bone Augmentation - comparison of Dome Technique with Guided Bone Regeneration: randomized clinical study	Not yet recruiting	Intervention	2025-09-25	<NULL>	<NULL>	8310	Horizontal Bone Augmentation of the Alveolar Ridge using the Polydioxanone Dome Technique versus Guided Bone Regeneration: a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-10-01	Departamento de Odontologia da Universidade Federal de Santa Catarina	Departamento de Odontologia da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2x5w7rf	<NULL>	Partially edentulous adult patients; minimum age of 18 years; with horizontal alveolar bone deficiency (less than 4 mm in thickness), confirmed by Cone-Beam Computed Tomography (CBCT); with adjacent teeth to the bone defect areas, in an edentulous space of no more than two missing teeth; adequate oral hygiene (plaque index of 25% or less); no history of bone augmentation procedures in the edentulous area; both sexes	Uncontrolled systemic and local conditions, such as uncontrolled diabetes; pregnant women; smokers; extraction sites with less than 3 months of healing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-9wyn4g7	Smart Pre-Surgery Prep: How a Carbohydrate Drink Can Improve Your Body’s Recovery	Not yet recruiting	Intervention	2025-09-26	<NULL>	<NULL>	8317	Effects of Carbohydrate Solutions (Preloading) on Physiological Outcomes and Endocrine-Metabolic Response to Perioperative Trauma in Patients Undergoing Elective Craniotom	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal do Piauí	Hospital Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-9wyn4g7	<NULL>	Individuals aged between 18 and 90 years; undergoing elective craniotomy for a single intracranial lesion; who signed the informed consent form	Exclusion criteria: patients with cranial trauma; emergency surgery (making it impossible to perform preoperative preparation with the solution); altered level of consciousness prior to surgery; lack of cooperation; pregnancy; presence of factors that delay gastric emptying or comorbidities that could affect postoperative recovery, such as: paralysis; spinal deformity; autoimmune diseases; coronary artery disease; severe infection; diabetes; or other dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8cq89mp	Effectiveness and safety of at-home tooth Whitening: a clinical study	Not yet recruiting	Intervention	2025-09-29	<NULL>	<NULL>	8323	Efficacy and safety of DSP Home Tooth Whitening: A prospective, single-Blind, randomized study	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-09-30	Universidade Estadual de Ponta Grossa	Programa de Pós Graduação em Odontologia da Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8cq89mp	<NULL>	Patients of both sexes; aged 18 years or older; in good general and oral health; absence of carious lesions, restorations, and endodontic treatment in at least the six maxillary anterior teeth; right and left maxillary canines with shade A2 or darker, assessed by comparison with a value-oriented shade guide	Patients with dental prostheses; orthodontic appliances; pregnant or breastfeeding women; smokers; participants with a history of tooth whitening procedures; individuals with bruxism; gingival recession; dentin exposure; visible cracks in the teeth; history of dentin hypersensitivity; users of anti-inflammatory medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-4b7xq9v	Safety and effects of using different Masks and Cannulas used to assist breathing in Premature Babies	Not yet recruiting	Intervention	2025-09-30	<NULL>	<NULL>	8333	Safety and effectiveness of different Interface models for Noninvasive Ventilation support for Preterm Newborns with gestational age greater than 28 weeks	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Fundação Hospitalar de Feira de Santana	Fundação Hospitalar de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-4b7xq9v	<NULL>	Preterm newborns, that is, those born before completing 37 weeks of gestational age; with a gestational age greater than 28 weeks; of both sexes; admitted to the neonatal intensive care unit; with mild to moderate respiratory distress identified by the Silverman Andersen bulletin; authorized by the guardian to participate in the research by signing the free and informed consent form	Patients with multiple congenital malformations; intolerant to non-invasive ventilation interfaces; patients whose legal guardians do not sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-452bhzf	Prophylaxis of postpartum hemorrhage in high-risk patients: a comparison between Carbetocin and Oxytocin. The PHARCO Study	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8336	Study on the prevention of postpartum hemorrhage: Carbetocin vs Oxytocin in high-risk patients	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2025-10-15	Hospital da Mulher Professor Doutor José Aristodemo Pinotti da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-452bhzf	<NULL>	Women; aged 18 years or older; receiving magnesium sulfate at the standard dose (intravenously with a loading dose of 4 g, followed by a maintenance dose of 1 to 2 g/hour); with an indication for delivery by vaginal birth or cesarean section	Women ;under 18 years of age; who decline to participate in the study; with a concurrent diagnosis of sepsis or intra-amniotic infection/chorioamnionitis; whose magnesium sulfate maintenance dose is not between 1–2 grams per hour; who received uterotonic medication more than 5 minutes after delivery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-2x24xpw	The effect of practicing mental and physical tasks performed at the same time on the ability to adjust gait in older adults with history of falls: a blinded randomized clinical trial	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8339	The effect of cognitive-motor training on adaptive locomotion in older adults with history of falls: a blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2x24xpw	<NULL>	Men and women; age between 65 and 80 years; intellectual capacity to understand verbal commands and to perform tasks; at least one fall in the last six months; ability to stand and walk independently without the use of assistive devices; present a MiniBEST score below the cutoff point for age-adjusted risk of falling	Cognitive deficits, such as Alzheimer&apos;s Disease; color blindness or other visual impairment not corrected by glasses or contact lenses; severe uncontrolled musculoskeletal, sensory, neurological or cardiovascular problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-33yz6xw	Effects of Video Games on the health of older adults	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8340	Effects of Active Video Games on the health of older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora, campus Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-33yz6xw	<NULL>	Individuals aged 60 years or older; of both sexes	Participants who have a medical diagnosis of psychological disorders (T.), for example: Social phobia; Bipolar disorder; Autism spectrum disorder (ASD); Personality disorder; Psychotic disorder; and Panic disorder. Neurodegenerative diseases, for example: Alzheimer&apos;s; Dementia; Parkinson&apos;s; Down syndrome; Multiple sclerosis; Autoimmune rheumatic disease; Hydrocephalus; Epilepsy; and Alcohol and/or illicit drug abuse. Cardiometabolic diseases, for example: Diabetes mellitus (type 1); Coronary artery disease; Stroke; and Chronic kidney disease. Lung diseases, for example: Chronic obstructive pulmonary disease; Pneumonia; Tuberculosis; and Bronchitis. Presenting symptoms suggestive of cardiovascular disease, such as: Syncope; Dyspnea; Tachycardia; and Angina. Presenting symptoms suggestive of neurodegenerative diseases, such as: persistent memory loss of recent events or important information; deficits in speech fluency or sentence construction; difficulty solving everyday problems or making simple decisions; difficulty recognizing people, objects, or places; irritability or aggression without apparent cause; difficulty performing simple motor tasks; loss of coordination and balance without apparent cause. Continuous use of psychotropic medications, such as antidepressants, anxiolytics, mood stabilizers, and/or stimulants, for a period of less than three months, an interval considered necessary for the body to adapt and minimize the initial effects of these medications. Introducing, throughout the intervention protocol, complementary therapies not initially planned, such as psychological and/or psychiatric interventions; use of medications that may influence the outcomes of interest; and the practice of physical or digital exercises that may impact the variables analyzed. Possess psychological or cognitive limitations; and/or osteoarticular conditions that prevent the practice of physical activity (PA) and/or medical impediment to the practice of PA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-6cdhmgx	Strategies for Dealing with Stress in Military Police Officers	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8343	Mindfulness as Coping Strategies for Burnout Syndrome in Military Police Officers: A Research Proposal for the 8th Battalion of the PMDF	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2025-10-01	Centro de Estudos Avançados e Multidisciplinares da Universidade de Brasília	Departamento de Educação e Cultura/Instituto Superior de Ciências Policiais	https://ensaiosclinicos.gov.br/rg/RBR-6cdhmgx	<NULL>	Active police officers; no history of serious mental disorders; agree to participate in all stages of the study	Reserve police officers; history of severe mental disorders such as bipolar disorder, schizophrenia, or other diagnosed psychotic disorders; refusal to participate in the study or failure to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-10tfg466	The Passage of Force between the two sides of the body induced by Palmar Grip Muscle Fatigue in right-handed women: a controlled experimental study	Not yet recruiting	Intervention	2025-10-02	<NULL>	<NULL>	8349	Motor Overflow Induced by Handgrip Fatigue in right-handed women: a controlled experimental study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10tfg466	<NULL>	Healthy volunteers; female; aged between 18 and 30; with motor preference for the right upper limb	Severe pain; discomfort during testing; inability to perform the experimental protocol as instructed; voluntary withdrawal; participants who fail to achieve at least 70% of maximum voluntary isometric contraction (MVIC) in the post-test measurement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-78dvhgs	Analysis of the stability of Implants with different macrogeometries	Not yet recruiting	Intervention	2025-10-03	<NULL>	<NULL>	8353	Comparative analysis of the initial stability of Dental Implants with different macrogeometries: in vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Márcio de Carvalho Formiga	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-78dvhgs	<NULL>	18 years old or more; systemic healthy; no contraindications for implant surgeries; no need for bone grafts; with at least one site in the need for implant supported rehabilitation; good oral health conditions;	smokers; diabetes; patients with history of use of bisphosphonates oral or endovenous; patients with the need for bone grafts; any type of systemic condition that would contraindicate oral surgeries;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-88hg3bh	Acupuncture on the control of nausea and vomiting in patients undergoing Bariatric Surgery in a private hospital in São Luís-Ma	Not yet recruiting	Intervention	2025-10-03	<NULL>	<NULL>	8355	Effect of acupuncture on the control of nausea and vomiting in patients undergoing Bariatric Surgery in a private hospital in São Luís-Ma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-88hg3bh	<NULL>	Patients undergoing bariatric surgery; aged 18 or over; with assessment of postoperative nausea and vomiting will be included in the study	Those who do not consent to participate in the research; contraindications to acupuncture techniques such as rash at the point of stimulation on the skin or systemic infection; severe obstructive sleep apnea syndrome; uncontrolled systemic diseases of the heart, lung, kidney or liver; coagulation disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-6k7gfy4	Evaluation of the effects of Orthostatism in critical patients: a randomized double-blind clinical trial	Not yet recruiting	Intervention	2025-10-05	<NULL>	<NULL>	8357	Effects of Orthostatism in Comatose patients admitted to the ICU: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-20	Universidade Federal do Delta do Parnaíba	Hospital Estadual Dirceu Arcoverde - HEDA	https://ensaiosclinicos.gov.br/rg/RBR-6k7gfy4	<NULL>	Patients admitted to the intensive care unit (ICU); of both sexes; aged 18 or over and 65 or under; who are on invasive mechanical ventilation (IMV) for at least twenty-four hours; in a coma of neurological or metabolic origin; with hemodynamic stability for carrying out the intervention	The study will not include patients under 18 years of age; patients with cardiac alterations confirmed by electrocardiogram (ECG); bronchopleural fistula; deep vein thrombosis; thrombocytopenia (below 50,000); body temperature above 37.8°C; orthopedic fractures in the lower limbs; orthopedic alterations that limit orthostatism; spinal cord injury; significant pressure injury in the calcaneus; use of intra-aortic balloon pump (IABP); intracranial pressure (ICP) monitoring catheter and/or external ventricular shunt (EVD); use of vasoactive drugs in high doses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-9qv5gd7	Metabolic profile and autonomic and cardiovascular recovery in hypertensive individuals under the acute effect of resveratrol	Not yet recruiting	Intervention	2025-10-05	<NULL>	<NULL>	8359	Acute effect of resveratrol on the metabolic profile and on autonomic and cardiovascular recovery in individuals with non-communicable chronic diseases	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-08-03	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9qv5gd7	<NULL>	Volunteers must be between 18 and 59 years of age. There will be no gender restrictions, however, study participants will be allocated to different groups based on male or female gender. Participants must not have skeletal muscle injuries	Patients with cardiorespiratory, neurological and other known impairments that prevent the subject from performing the procedures. Women will not be included in the period of 10-15 days and 20-25 days after the first day of the menstrual cycle to avoid influence of the luteal and follicular phases of the menstrual cycle. Participants will be instructed not to drink alcoholic beverages or consume substances containing resveratrol (for example, teas, açaí, chocolate, whole grape juice, red or white wine and soft drinks). Do not perform high-intensity training for 24 hours prior to the evaluation. Consumption of grape juice, caffeine, alcoholic beverages or any other type of substance prior to the procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-2gcb7ht	Diet and pain in women with Temporomandibular Disorder (TMD)	Not yet recruiting	Observational	2025-10-06	<NULL>	<NULL>	8361	Dietary profile of women with chronic Temporomandibular Joint Disorder	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2gcb7ht	<NULL>	a pain complaint with a minimum intensity of 5, measured by a numerical pain scale ranging from 0 (no pain) to 10 (worst possible pain), with the main pain in the temporomandibular joint region and no previous treatment in the last three months; the healthy group will consist of women without a diagnosis of temporomandibular dysfunction and without a history of facial pain	women with previously diagnosed incapacitating cognitive, psychological or neurological alterations; other chronic pain disorders; abuse of licit drugs or alcoholic beverages; use of illicit drugs; heart disease; pregnant and lactating women will be excluded; volunteers with loss of five or more dental elements; ill-fitting prostheses; severe periodontal disease; odontalgia; intra- or extra-oral lesions that compromise masticatory function; food intolerances; diabetes mellitus or other systemic conditions that may lead to food restriction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-82c8gr7	Aromatherapy foot bath: a randomized trial for Depression, Anxiety, and Minor Disorders	Not yet recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8363	The use of Complementary Integrative Practices, PIC&apos;s, in the municipality of Londrina, UEL, city hall of Londrina	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-82c8gr7	<NULL>	trabalhadores da saúde que atuam direta e indiretamente com o cuidado do paciente, que atuam em um hospital terciário	Retired workers or those with planned and unplanned absenteeism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-89sxw55	Realistic simulation for learning how to use pain medications	Not yet recruiting	Intervention	2025-10-09	<NULL>	<NULL>	8381	Enhancing clinical competencies in opioid management through realistic simulation: an experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	UNB Ceilândia - Faculdade de Ciências e Tecnologias em Saúde	UNICEPLAC - Centro Universitário do Planalto Central Apparecido dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-89sxw55	<NULL>	Volunteer students aged 18 or over and regularly enrolled in courses dealing with Perioperative Nursing.	Student volunteers who are nursing technicians or first responders, or those on sick leave.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-5j5swn8	Study protocol on Aerobic Exercise and Multimodal Training for people with Parkinson’s disease	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8392	Effect of Aerobic Exercise compared to a Multimodal Training on functional capacity and quality of life in individuals with Parkinson’s disease: randomized clinical trial protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-02	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5j5swn8	<NULL>	Individuals diagnosed with Parkinson’s disease; minimum age of 30 years; both sexes; varying levels of education; currently at stages I, II, or III on the Hoehn &amp; Yahr scale	Individuals who present acute osteomyoarticular injuries or limiting cardiac alterations; Dementia; Uncontrolled severe psychiatric illness or current psychotic symptoms, which would be characterized as a contraindication for the practice of physical activity; Unjustified absence; clinical instabilityity practice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5j4wkxk	Effects of S-PRG Nanoparticles Dispersion on Gum Tissues	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8398	Evaluation of the effects of S-PRG Nanoparticle dispersion on periodontal tissues: in vitro analysis of biological interactions and clinical trial in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-10	Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5j4wkxk	<NULL>	Individuals with gingivitis presenting a gingival bleeding index equal to or greater than 10%; probing depth equal to or less than 3 mm; aged 18 years or older; in good general health; and willing to participate in the study by signing the informed consent form	Individuals with periodontitis; smokers; pregnant or breastfeeding women; individuals who have used mouthwashes within the past 6 months; those under chronic use of medications that affect periodontal response, such as antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants, or sodium channel blockers within the past 6 months; individuals with systemic conditions such as diabetes, cardiovascular disease, cancer, obesity, rheumatoid arthritis, metabolic syndromes, respiratory diseases, or those requiring antibiotic prophylaxis; and individuals wearing orthodontic appliances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5bftcwk	Tongue tie and motor development in children: a prospective cohort study	Not yet recruiting	Observational	2025-10-13	<NULL>	<NULL>	8399	Oral ties and motor development in children: a prospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-5bftcwk	<NULL>	Newborns over 37 weeks; weight greater than or equal to 2,500 grams; mothers aged at least 18 years	Babies with congenital anomalies or neonatal conditions that prevent breastfeeding; babies who require intensive care unit (NICU); babies whose mothers test positive for human immunodeficiency virus (HIV) and/or human T-cell lymphotropic virus (HTLV); babies from multiple pregnancies; mothers who live in other cities where transportation is difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-8r3vzw5	Study on how Dignity Therapy can help people with advanced cancer maintain their sense of dignity and well-being at the end of life	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8402	Effects of Dignity Therapy on the sense of dignity and spiritual well-being of patients with advanced cancer at the end of life: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-15	Departamento de Enfermagem da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8r3vzw5	<NULL>	Age of eighteen years or older. All genders. Diagnosis of advanced cancer considered incurable, including solid tumors or hematologic malignancies. Life expectancy of six months or less, as determined by a score of three on the Eastern Cooperative Oncology Group performance scale or clinical judgment of the care team. Active participation in inpatient palliative care. Availability and willingness to participate in up to four sessions within a period of up to fourteen days. Functional ability to communicate in Portuguese. Cognitive functioning compatible with participation in the intervention, as assessed by the Mini-Mental State Examination	Severe cognitive impairment, such as dementia or delirium, that interferes with participation in the intervention, identified clinically or by the screening tool. Clinical diagnosis of severe mental disorder. Severe language disturbances that impair comprehension or communication. Evidence of a conspiracy of silence between the care team and the family	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5s76ksq	Non-invasive brain stimulation in neurological conditions	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8405	Non-invasive neuromodulation in neurological clinical conditions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-5s76ksq	<NULL>	Participants aged 18 years or older; of both sexes; who provide written informed consent will be included; eligibility requires a functional diagnosis of communication disorders or stomatognathic dysfunctions of neurological etiology (dysphagia, dysphonia/dysarthrophonia, aphasia, or somatosensory tinnitus); a functional diagnosis of gait and balance disorders; chronic pain; and/or a sympathetic or parasympathetic index outside the normal range (–1 to 1) in heart rate variability, observed in at least two of the three measurements of the orthostatic test	Participants who do not use the Portuguese oral language; who have rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis; with cardiac arrhythmia or other cardiovascular conditions using beta-blockers; pregnant women or women in the puerperium or postpartum period; patients diagnosed with cancer and severe osteoporosis; who have absolute contraindications for non-invasive brain stimulation (pacemaker, epilepsy, cochlear implant)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-4pf8kms	Should we wait until sufficient good teeth brushing before periodontal treatment? A randomized clinical trial	Not yet recruiting	Intervention	2025-10-14	<NULL>	<NULL>	8411	Influence of achieving sufficient mechanical control of the supragingival biofilm before subgingival instrumentation in patients with Periodontitis: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4pf8kms	<NULL>	Periodontitis Stages II-IV Grades B and C, generalized: for Stages II-IV (case definition): present at least 1 tooth with at least one interproximal site with a probing depth greater than or equal to 5 mm and attachment loss greater than or equal to 4 mm. For Grade B: have a report of attachment loss of less than 2 mm in the last 5 years or have a bone loss/age percentage (of the most affected tooth) . between 0.25 and 1. For Grade C: have a report of attachment loss greater than or equal to 2 mm in the last 5 years or have a bone loss/age percentage (of the most affected tooth) greater than 1. Present a minimum of 15 teeth (excluding third molars and teeth indicated for extraction). Minimum of 6 teeth with at least 1 non-contiguous interproximal site with a probing depth greater than or equal to 5 mm and a clinical attachment level greater than or equal to 4 mm. Both sexes. Age greater than or equal to 30 years.	Smokers of at least 10 cigarettes/day for at least 5 years; former smokers for at least 5 years; pregnant or lactating; history of periodontal treatment in the last 6 months; continuous use of oral antiseptics; use of systemic antibiotics, corticosteroids, nonsteroidal anti-inflammatory drugs, immunosuppressants, estrogen, and estrogen receptor modulators; medications that may influence bone metabolism (alendronate, calcitonin, and others) in the last 6 months; systemic disease that may alter the host response to periodontal treatment (e.g., diabetes) or that requires prophylactic medication for dental treatment (e.g., mitral valve prolapse); use of orthodontic appliances; extensive prosthetic rehabilitation and blood dyscrasias; patients with motor limitations that have a significant impact on biofilm self-control (e.g., patients with stroke sequelae)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-67bq38w	Effect of testosterone replacement in hypogonadal men with overweight and obesity: a clinical trial	Not yet recruiting	Intervention	2025-10-15	<NULL>	<NULL>	8415	Effect of testosterone replacement associated with diet and physical activity in hypogonadal men with overweight and obesity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Hospital e Maternidade São Domingos	Hospital e Maternidade São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-67bq38w	<NULL>	Obese or overweight men (Body Mass Index above 25 and less than 35; between 30 and 60 years of age; with low testosterone levels (less than 350 nanograms per deciliter); with symptoms of hypogonadism	Individuals interested in fertility in the 6 months following therapy; presence of Diabetes Mellitus; presence of hypertension; presence of Nephropathy; presence of heart disease; presence of Hepatopathy; presence of Depression; presence of anxiety disorders; presence of other hormonal diseases; presence of Hypogonadism of primary cause (testicular failure); diagnosis of active prostate or breast cancer; previous diagnosis of breast cancer; severe urinary symptoms through the score; International Prostate Symptom Score greater than 19; severe cardiopulmonary disease such as unstable angina and recent myocardial infarction; personal or family history of Thromboembolism; hematocrit above 48 percent; patients with implanted medical devices (pacemakers) or essential support devices such as monitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-73hswmb	Laterality and mirror therapy for surgically treated distal radius Fracture	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8416	Effectiveness of a laterality and mirror therapy protocol versus graded motor imagery on pain, function, and quality of life in women with surgically treated distal radius Fracture: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital Herminda Martin	Universidad San Sebastián	https://ensaiosclinicos.gov.br/rg/RBR-73hswmb	<NULL>	Women; over 18 years old; diagnosed with Unilateral Distal Radius Fracture and treated surgically	Polytraumatized patients; patients with secondary distal radius fractures (tumors, pathological bone, etc.); complicated distal radius fractures (associated with other musculoskeletal, vascular, or neurological injuries); patients with decompensated rheumatic, neurocognitive, or psychiatric diseases; patients with visual impairment preventing completion of study protocols; cognitive impairment assessed with the Mini-Mental State Examination (MMSE); and patients with complex regional pain syndrome (CRPS) at baseline	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7zbz3p3	Auriculotherapy in the birth process	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8417	Effects of Auriculotherapy on the birth process: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Estadual de Londrina	Santa Casa de Misericórdia de Cambé	https://ensaiosclinicos.gov.br/rg/RBR-7zbz3p3	<NULL>	Chronological age over 18 years; from 37 weeks; regardless of parity; who are admitted for induction of labor	Pregnant women who are induced using the Krause method	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-3t3z37t	Comparison of the effects of two suspension training protocols on the pain and musculoskeletal function of individuals with chronic low back pain	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8419	Comparison of the effects of two suspension training protocols on pain and skeletal muscle function of individuals with chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-10	Universidade Federal do Paraná	Centro de Estudos em Prescrição Clínica do Exercício (CEPREX)	https://ensaiosclinicos.gov.br/rg/RBR-3t3z37t	<NULL>	Volunteers with chronic, nonspecific, persistent, or periodic low back pain; military personnel; age range between 18 and 59 years; pain intensity greater than 3 on the numerical pain scale; moderately active according to the Human Activity Profile Questionnaire.	Body mass index greater than or equal to 30 kg/m2; no physiotherapy treatment concurrent with the study period; no surgery in the lumbar region; no clinical diagnosis of low back pain; no low back pain radiating to the glutes and lower limbs; use of medication for low back pain relief 48 hours before performing the exercises; previous diagnosis of heart disease; neurological disease; uncontrolled hypertension (less than 1 year after starting medication); acute lung disease; orthopedic injuries; failure to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-2w8s4r9	Randomized clinical trial comparing primary anterior cruciate ligament reconstruction with hamstring grafts with and without the bioinductive implant Biobrace®	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8420	Randomized double-blind clinical trial comparing the functional outcomes of patients undergoing primary anterior cruciate ligament reconstruction with hamstring grafts with and without the use of intra-articular reinforcement with the bioinductive implant Biobrace®	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2w8s4r9	<NULL>	Patients with unilateral anterior cruciate ligament injury with surgical indication, with or without associated meniscal lesions; Patients with skeletal maturity; Both genders; Aged between 16 and 50 years	Presence of other associated ligament injuries requiring reconstruction; Patients with mechanical axis deviation of the lower limb requiring corrective osteotomy; Presence of chondral lesions requiring repair; Presence of associated fractures or other pathological conditions of the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-56gdnqk	Effects of Laser Therapy on the lips of mouth-breathing children	Not yet recruiting	Intervention	2025-10-17	<NULL>	<NULL>	8423	Effects of Orofacial Myofunctional Therapy combined with Photobiomodulation in mouth-breathing children: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-56gdnqk	<NULL>	Mouth-breathing children of both sexes, aged between 5 and 12 years; who have signed the Informed Assent Form (IAF) and whose respective guardian has signed the Informed Consent Form (ICF); who have not used muscle relaxant and/or anti-inflammatory medication within the 48 hours prior to data collection; participants who do not present contraindications to phototherapy	Failure to complete all proposed tasks; low quality of the electromyographic signal; absence of dento-skeletal conditions necessary to achieve lip sealing; obstruction that prevents nasal breathing; lip sealing performed with effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-6fcwx9s	Comparison between the direct cut technique above the duodenal papilla and the traditional attempt to access the bile duct	Not yet recruiting	Intervention	2025-10-20	<NULL>	<NULL>	8425	Needle-knife fistulotomy versus conventional cannulation attempt: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6fcwx9s	<NULL>	Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) for the first time; favorable papillary morphology; infundibular bulging of at least 8 mm, with a minimum distance of 3 mm from the papillary orifice and a minimum length of 5 mm for endoscopic incision; age over 18 years; agreement with the Informed Consent Form	Refusal to sign the Informed Consent Form (ICF); previous endoscopic retrograde cholangiopancreatography (ERCP); coagulopathy; surgical history that alters endoscopic access to the biliary tract (e.g., gastrectomy with Billroth II or Roux-en-Y reconstruction); pancreatic sphincterotomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-7bcs3m4	Reducing ageism against older adults: evaluation of the effectiveness of an educational intervention in Primary Health Care	Not yet recruiting	Intervention	2025-10-20	<NULL>	<NULL>	8426	Ageism among Primary Health Care professionals: associated factors and effectiveness of an educational intervention in reducing ageist attitudes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-15	Faculdade de Enfermagem - FENF / Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-7bcs3m4	<NULL>	Health professionals with mid-level or higher education; both genders; working in Primary Health Care Units for at least three months; weekly workload equal to or greater than 30 hours	Professionals absent from work for any reason including vacation and leave; participants not reached by phone after three attempts at different days and times; non-completion of the intervention on the Moodle platform	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-62kz97v	Effect of specific Exercise with orthopedic Brace combined customized Insole in adolescents with Idiopathic Scoliosis	Not yet recruiting	Intervention	2025-10-21	<NULL>	<NULL>	8430	Therapeutic effect of specific Exercise and use of orthopedic Brace combined with 3D customized Insole in adolescents with Idiopathic Scoliosis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-31	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	https://ensaiosclinicos.gov.br/rg/RBR-62kz97v	<NULL>	Adolescents aged 11 to 18 years; diagnosis of adolescent idiopathic scoliosis; both genders	Symptomatic musculoskeletal diseases in the lower limbs; symptomatic diseases of the central and peripheral nervous system; diabetes mellitus; corrective surgery for spinal curvature; rigid foot deformities; injections in the feet and ankles in the last three months; previous or planned spinal surgery in the next twelve months; and mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4d9p9j5	Pilates Program for Knee Arthritis: Using an Educational Guide	Not yet recruiting	Intervention	2025-10-21	<NULL>	<NULL>	8434	Adherence to an Educational Booklet for Knee Osteoarthritis after a Pilates program	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4d9p9j5	<NULL>	Participants must have a clinical diagnosis of osteoarthritis according to the criteria of the American College of Rheumatology, which include knee pain and the presence of at least one of the following characteristics, age equal or above 50 years, knee crepitus during movement, increased sensitivity to compression, reduced local warmth, bony enlargement, morning stiffness lasting less than 30 minutes or radiological evidence of knee osteoarthritis of grade 2 or higher according to the Kellgren and Lawrence criteria which are as follows, grade 0 (no changes), grade 1 (doubtful joint space narrowing and possible osteophytes), grade 2 (possible joint space narrowing with definite osteophytes), grade 3 (definite joint space narrowing, definite osteophytes, and subchondral sclerosis with possible bony deformity), and grade 4 (marked joint space narrowing, definite osteophytes, definite bony deformity, and severe subchondral sclerosis); present a score equal or above 3 on the numerical pain rating scale	Asymptomatic knee osteoarthritis; surgeries performed on the lower limbs; confirmed diagnosis of neurological, inflammatory, infectious, rheumatologic, or traumatic disorders; severe visual impairment; presence of lower limb prosthesis; inability to understand the Portuguese language; body mass index (BMI) greater than 40; physiotherapy treatment within the past three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4bmwsdz	Study on the use of Ibogaine for the treatment of Cocaine and Crack Addiction	Not yet recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8440	Phase II/III randomized and multicenter clinical trial to analyze the efficacy and safety of Ibogaine (Voacanga africana) in the treatment of Cocaine and Crack Dependence	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2026-01-01	Instituto Veracruz de Pesquisa e Tratamento da Dependência Química Ltda.	Instituto Veracruz de Pesquisa e Tratamento da Dependência Química Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4bmwsdz	<NULL>	Volunteers able to understand the study procedures and voluntarily consent by signing the Informed Consent Form. Men and women aged between eighteen and fifty-five years. Diagnosis of mental and behavioral disorders due to use of cocaine, dependence syndrome or mental and behavioral disorders due to multiple drug use or use of other psychoactive substances, dependence syndrome, classified as severe. Clinical, physical and psychological evaluation within normal limits or with alterations not clinically significant at the investigators discretion. History of at least one unsuccessful attempt to reduce or cease substance use, such as hospitalization, therapeutic community treatment, self help groups or psychological follow up. Agreement to maintain abstinence from cocaine and or crack for thirty days prior to administration of the investigational product. Agreement to maintain abstinence and washout from other substances and medications prior to administration of the investigational product. Availability to participate in all stages of the protocol, including twenty four hours of hospitalization and twenty four weeks of outpatient follow up	Volunteers with a history of severe cardiovascular diseases including angina, acute myocardial infarction, coronary artery disease, heart failure, arrhythmias, endocarditis, syncope of unknown origin or significant electrocardiographic alterations. Uncontrolled systemic arterial hypertension. Uncontrolled diabetes mellitus. Clinically relevant hepatic, renal, gastrointestinal, pulmonary, hematological or metabolic diseases. Previous diagnosis of severe neurological or psychiatric disorders such as schizophrenia, bipolar disorder, other psychoses, epilepsy, Alzheimers disease, Parkinsons disease or head trauma with loss of consciousness. Previous or current history of suicidal ideation. Previous treatment with ibogaine or noribogaine. Known hypersensitivity to ibogaine, its derivatives or excipients of the investigational product formulation. Clinically significant alterations in safety laboratory tests or in the twelve lead electrocardiogram that may endanger the participants health at the investigator’s discretion. Use of antidepressants within thirty days before administration of the investigational product. Use of nicotine within twelve hours before or forty eight hours after administration of the investigational product. Use of alcohol within fifteen days prior to administration. Confirmed pregnancy or lactation. Positive serology for HIV, hepatitis B or hepatitis C. Positive drug test on the day of ibogaine administration except for substances for which there is no restriction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7jkmhf5	Doxi-Rio: study on the use of Doxycycline to prevent sexually transmitted infections in Rio de Janeiro	Not yet recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8442	Doxi-Rio: pilot implementation of post-exposure prophylaxis for sexually transmitted infections with Doxycycline in Rio de Janeiro, Brazil	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Instituto Nacional de Infectologia Evandro Chagas	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-7jkmhf5	<NULL>	Men (cis or trans) who have sex with men, transvestites or trans women; diagnosed with HIV infection or current use of PrEP for at least 6 months; age 18 years or older; laboratory diagnosis or self-reported diagnosis of at least one bacterial sexually transmitted infection (Chlamydia, Gonorrhea or Syphilis) in the last 12 months; consent to participate in the study after receiving adequate information about the study	Allergy to antibiotics of the Tetracycline class; current medications that may impact the metabolism of Doxycycline or that are contraindicated with Doxycycline (Systemic Retinoids, Barbiturates, Carbamazepine and Phenytoin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-5x5yy7w	How strength training with controlled speed compares to traditional training in the elderly: impacts on muscles and functions	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8455	Effects of velocity-based strength training compared to traditional strength training on neuromuscular and functional parameters in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-20	Universidade Comunitária Da Região De Chapecó	Universidade Comunitária Da Região De Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-5x5yy7w	<NULL>	Elderly individuals of both sexes; aged between 60 and 70 years	People with clinical or motor restrictions preventing physical exercise; who have participated in systematic strength training programs in the two months prior to this study; participants who miss a total of three training sessions or two consecutive sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-54z4k5x	Teaching in the care of patients with long-term left ventricular assist devices	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8456	Teaching strategies for the learning process of care for patients with long-term left ventricular assistive device	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-14	Faculdade de Medicina da Universidade de São Paulo	Hospital Do Coração/Associação Beneficente Síria - HCOR	https://ensaiosclinicos.gov.br/rg/RBR-54z4k5x	<NULL>	Doctors and nurses enrolled in the e-learning and in-person sessions of the course	professionals who refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-2x9sjks	Study on the effects of infrared light on memory, attention and concentration in healthy young adults	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8457	The cognitive effects of LASER Photobiomodulation Therapy in healthy subjects: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2026-03-02	Sociedade de Educação Superior e Cultura Brasil S.A.	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2x9sjks	<NULL>	Be a regular student of the medical course at the University of Southern Santa Catarina UNISUL; of both sexes; be between 18 and 25 years old	Failure to sign the Free and Informed Consent Form FICF; have a history of or present epileptic episodes; use psychiatric medication; be pregnant or breastfeeding; be an oncology patient	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-10438p9q	Exercise program, Walking and Balance Training with Shoes and Insole associated with Pain Education in older women with Plantar Fasciitis	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8460	Therapeutic effect of the intervention program with Exercise, Gait Retraining and Balance with Footwear and Insole associated with Education in Pain Neuroscience of elderly women with Plantar Fasciitis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-24	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	https://ensaiosclinicos.gov.br/rg/RBR-10438p9q	<NULL>	Women; aged between 60 and 80 years; body mass index (BMI) less than 35 kg/m²; walk independently for at least 6 hours a day; do not use orthoses to perform daily activities	History of knee, ankle, or hip surgery in the last 6 months; muscle injury in the last 6 months; diagnosed neurological disease; diagnosed rheumatological disease; leg length discrepancy greater than 1 cm; presence of hallux rigidus; indication for fasciotomy; presence of arthroplasty or indication for arthroplasty during the intervention period; use of lower limb orthoses; corticosteroid injection in the heel in the last 3 to 6 months; ankle joint instability; dementia or inability to provide consistent information; use of minimalist flexible footwear or similar shoes for more than 25 hours per week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9s9hc29	The effect of the anesthetic Clonidine combined with Bupivacaine for pain control in patients who underwent Vitrectomy surgery	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8461	Evaluation of the effect of Clonidine associated with Bupivacaine in peribulbar block for patients undergoing Vitrectomy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-11-01	Hospital e Maternidade São Domingos	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-9s9hc29	<NULL>	Patients older than 18 years; American Society of Anesthesiologists - ASA physical status I, II or III; of both sexes; undergoing vitrectomy; after signing the Informed Consent Form	Patient refusal of the block; coagulopathy or use of anticoagulants; altered state of consciousness; non-cooperative patient; uncontrolled arterial hypertension; recent acute myocardial infarction (&lt;6 months); glaucoma; recent analgesic therapy (&lt;2 weeks); chronic use of clonidine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-8zfdnd4	Psychomotor stimulation through musical practice using the Orff approach in children for the development of  spatial and temporal perception	Not yet recruiting	Intervention	2025-10-28	<NULL>	<NULL>	8464	Psychomotor stimulation focused on spatio-temporal structuring and Orff practice randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal de Alfenas UNIFALMG	<NULL>	<NULL>	<NULL>	Children enrolled in school in the school year/grade (4 and 5 years old); children whose parents agree to participate and sign the informed consent form.	Children who do not have physical or mental disabilities; children who did not participate in extracurricular activities such as swimming, martial arts, and ballet; children with orthopedic injuries that prevent them from performing psychomotor activities; children who are not enrolled in the Diadema Municipal Basic Education School.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:43
RBR-2b4t4y2	Efeitos da Eletroestimulação Auricular Vagal em Fibromialgia	Not yet recruiting	Intervention	2025-10-29	<NULL>	<NULL>	8470	Effects of transcutaneous auricular vagal electrical stimulation in individuals with fibromyalgia: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-03	Universidade Estadual da Paraíba	<NULL>	<NULL>	<NULL>	Women; aged between 18 and 70 years; with a diagnosis of fibromyalgia (the diagnosis will be made by a physician referred by the patient and confirmed by a physical therapist with experience in rheumatology), taking into account the diagnostic criteria for fibromyalgia from the American College of Rheumatology.	Participants who are pregnant, have a history of epilepsy, have a metal implant, have undergone neurosurgery, have a psychiatric illness such as schizophrenia and bipolar disorder, otitis, and those with cognitive impairment expressed with difficulty in speaking and/or understanding and visual deficit that prevent the completion of the scales.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:39
RBR-6pbpwpm	Study on sending text messages to help pregnant women with Syphilis follow treatment correctly	Not yet recruiting	Intervention	2025-10-29	<NULL>	<NULL>	8472	Use of short messages through mobile messaging applications to improve adherence to Syphilis treatment during pregnancy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-17	Centro Universitário Norte do Espírito Santo – Universidade Federal do Espírito Santo (UFES)	<NULL>	<NULL>	<NULL>	Pregnant women diagnosed with syphilis infection during pregnancy; before starting treatment or shortly after the first dose of benzathine penicillin; age 18 years or older; reside in the study area; have access to a mobile phone capable of receiving and sending text messages; willing to be followed up for up to six weeks after delivery	Pregnant women who have already completed syphilis treatment in the current pregnancy; pregnant women unable to communicate via text messaging; pregnant women who do not agree to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:41
RBR-88k7mvw	Effect of topical application of 10% Silver Nitrate solucion versus 10% Potassium Hydroxide in the treatment of Molluscum Contagium	Not yet recruiting	Intervention	2025-11-01	<NULL>	<NULL>	8474	Efficacy and safety of topical application of 10% Silver Nitrate solucion versus 10% Potassium Hydroxide in the treatment of Molluscum Contagium	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Patients with a clinical diagnosis of molluscum contagiosum, without perimolluscal eczema; aged between one and twelve years; of both sexes; whose parents or legal guardians have signed an informed consent form	Individuals with congenital or acquired immunosuppression; children who have used another treatment in the last month; patients with lesions on the face or genital region; children with allergies to the components of the medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:25
RBR-10vqn68h	Nutritional Supplements: Understanding the Responses in Strength and Endurance Training	Not yet recruiting	Intervention	2025-10-31	<NULL>	<NULL>	8478	Nutritional supplements and responses to different physical activity programs	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-10	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	Male individuals who regularly practice physical activity; Age between 18 and 35 years; Regular practice of physical activity for at least 24 months	Smoker; Patients with diabetes and/or cardiovascular diseases; History of osteoarticular injury in the last six months. Use of any ergogenic resource and / or dietary supplement; Failure to attend LEMOH or the Sports Nutrition Laboratory on the days of tests	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:29
RBR-6m2hb8h	Evaluation of the cardioprotective effects of Dapagliflozin in patients with Sickle Cell Disease	Not yet recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8480	Use of Dapagliflozin in adults patientes with Sickle Cell Disease	<NULL>	2, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2027-01-01	Centro de Hematologia e Hemoterapia da Unicamp – Hemocentro da UNICAMP	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; both sexes; confirmed diagnosis of sickle cell disease (homozygous sickle cell anemia SS or compound heterozygous SB); signed Informed Consent Form (ICF)	Pregnancy; severe liver failure; current use of sodium-glucose cotransporter 2 inhibitor (SGLT2i)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:31
RBR-8zhtrv4	Feasibility study of transcranial direct current stimulation (tDCS) efficacy in patients with neurogenic dysphagia	Not yet recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8483	Non-invasive brain stimulation in neurological conditions	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Eligibility criteria include adults (≥18 years) with a confirmed neurological diagnosis and clinical signs or symptoms of swallowing disorders	Patients receiving alternative feeding methods (e.g., enteral tube feeding or gastrostomy) and those with intracranial metallic implants or cardiac pacemakers will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:34
RBR-82fjc5f	Randomized controlled clinical trial evaluating a complementary Spiritual Intervention adjunctive to conventional psychiatric inpatient treatment	Not yet recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8484	Effectiveness of a complementary Spiritual Intervention to conventional psychiatric treatment in hospitalized patients with suicidal behavior: an observational intervention study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Adult patients admitted to a psychiatric inpatient unit	Significant cognitive disorganization that prevents the participant from understanding and adequately responding to the questionnaires used for data collection	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:35
RBR-4mztsnq	Effects of cannabis extract cream on nerve and blood-deprived wound healing: randomized trial	Not yet recruiting	Intervention	2025-11-07	<NULL>	<NULL>	8490	Effects of Cannabis extract cream on the healing process of neuropathic and ischemic wounds: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Sociedade De Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Age 18 years or older. diagnosis of type 2 diabetes mellitus. presence of neuropathic or ischemic wound in lower limbs. under follow-up at primary health units or at Policlínica Santa Maria in the city of Cajazeiras. medical prescription for use of the Cannabis-based cream. signing of the informed consent form	Wounds not related to diabetes such as those of traumatic or burn origin. known allergy to any component of the cream formulation. simultaneous participation in another clinical trial. presence of severe clinical or psychiatric conditions that impair protocol adherence. pregnancy or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:06
RBR-3s85fz4	Double conjunctival flap with suture versus conjunctival autograft with glue for primary pterygium: a prospective, randomized study	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8496	Conjunctival autotransplantation with glue versus double flap with suture for primary pterygium. Interventional study	<NULL>	2, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-20	Hospital Universitário da Universidade Federal do Maranhão/HU/UFMA	<NULL>	<NULL>	<NULL>	The inclusion criteria will be patients aged over 18 and under 80 years; without the occurrence of ocular surface disease, including dry eye and blepharitis, and with availability for clinical follow-up for at least six months after surgery. This information will be collected during ophthalmological consultations. To eliminate duplication bias when using both eyes from the same patient, only the first operated eye will be included in the analysis.	Exclusion criteria will include patients under 18 or over 80 years of age; presence of symblepharon; cicatricial conjunctival diseases; glaucoma; ocular allergy; recurrent pterygium in the ipsilateral eye, and those who do not sign the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:13
RBR-3vqhv5d	Effects of a training program involving vascular Occlusion and Jumping on the functionality of elderly people	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8497	Effects of a training program involving Ischemic Preconditioning and Jumps on the functionality and power of the lower limbs of elderly individuals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-05	Universidade São Judas Tadeu	<NULL>	<NULL>	<NULL>	Individuals of both sexes will be included; aged ≥ 60 years and &lt; 71 years; who are available to participate in the intervention program at least three times a week for 12 weeks	Participants with the following clinical conditions will be excluded: recent acute myocardial infarction or unstable angina; uncontrolled atrial or ventricular arrhythmias; dissecting aortic aneurysm; severe aortic stenosis; acute endocarditis or pericarditis; uncontrolled arterial hypertension; acute thromboembolic disease; severe acute heart failure; severe acute respiratory failure; uncontrolled orthostatic hypotension; diabetes mellitus with acute decompensation or uncontrolled hypoglycemia; recent fracture (in the last month); or any other medical condition that prevents the performance of the physical activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:14
RBR-77f8rjq	Effects of the combination of Electrical Stimulation and Exercise on pain, strength, and mobility in people with knee Osteoarthritis	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8498	Effects of adding Neuromuscular Electrical Stimulation to Resistance Exercise on pain, self-reported physical function, muscle torque, and performance-based physical function in patients with knee Osteoarthritis: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-30	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Participants with a diagnosis of knee osteoarthritis according to the clinical criteria of the American College of Rheumatology; aged 18 years or older; no gender restrictions	Secondary knee osteoarthritis (e.g., septic arthritis, inflammatory joint disease, gout, articular fracture, severe dysplasias, congenital abnormalities, or hemochromatosis); systemic arthritic conditions; history of arthroplasty or other surgical interventions in the knee or hip; associated neurological diseases that impair lower limb function (such as post-stroke, neuropathies, or multiple sclerosis); contraindications and precautions related to neuromuscular electrical stimulation, including patients with pacemakers or cardiac defibrillators, deep vein thrombosis, areas with diagnosed or suspected malignancies, active bleeding, infection, skin disease, areas with impaired sensation, or pregnancy; intra-articular corticosteroid injection within the past three month	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:42
RBR-4qrd3qt	Nutrition, routine examinations, and physical tests for youth soccer players	Not yet recruiting	Intervention	2025-11-04	<NULL>	<NULL>	8499	Nutritional status, biomarkers, and performance indicators of youth soccer players	<NULL>	n/a, non-randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de Jataí	<NULL>	<NULL>	<NULL>	Male athletes; aged between 14 and 20; registered with soccer federations; fit to participate in sports activities during the collection period	Foreign athletes; individuals with less than two years of federation membership; athletes sidelined due to musculoskeletal injuries; athletes medically unfit for a period of six months or longer	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:16
RBR-27sf3w5	Effects of a Multiprofessional Intervention on the Health of Elderly Individuals After COVID-19	Not yet recruiting	Intervention	2025-11-04	<NULL>	<NULL>	8501	Effects of a Multiprofessional Intervention on Health-Related Physical Fitness, Nutritional Profile, and Mental Health of Elderly People Post-Covid-19 According to Nutritional Status: A Clinical Trial	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-11	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Older adults of both sexes aged between 60 and 79 years, with persistent post-COVID-19 symptoms or without a history of COVID-19 infection, who are physically able to perform moderate to vigorous intensity physical exercise and available to regularly participate in the project activities will be included	Participants with debilitating neurological diseases such as Alzheimer’s disease; Parkinson’s disease, or plegias; or those with reduced intellectual capacity; will not be eligible for this study. Individuals currently using corticosteroids or with chronic or acute conditions that contraindicate physical exercise or may alter the response to the intervention will be excluded. Participants with disabling atherosclerotic disease, class 4 congestive heart failure, active rheumatoid arthritis, advanced renal or hepatic disease, undergoing chemotherapy for cancer, or other similar conditions will also be excluded. Finally, participants who attend less than 85% of the intervention sessions will not be considered	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:20
RBR-858vntn	Using Virtual Reality to relieve pain and anxiety during Hemodialysis access puncture	Not yet recruiting	Intervention	2025-11-16	<NULL>	<NULL>	8504	Effect of Virtual Reality on pain and anxiety during Arteriovenous Fistula puncture: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Departamento de Enfermagem	<NULL>	<NULL>	<NULL>	Participants of both sexes; age ≥18 years; undergoing hemodialysis through arteriovenous fistula puncture for at least 4 weeks and at most 4 months; functional and stable arteriovenous fistula in the last three sessions, without signs of infection; absence of neurological or cognitive conditions capable of interfering with the intervention or data collection.	Visual or auditory hypersensitivity; use of pharmacological therapy for anxiety or antidepressants; use of analgesics in the 24 hours prior to the procedure; history of severe migraine or balance disorders; requirement of a new puncture of the fistula during the procedure; hemodynamic instability.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:25
RBR-32j9y23	Comparison between two regional anesthesia techniques to relieve pain after partial breast removal surgery (Quadrantectomy)	Not yet recruiting	Intervention	2025-11-16	<NULL>	<NULL>	8505	Comparison between Pectoral Plane Block (PECS I AND II) and Erector Spinae Plane Block (ESP) for postoperative analgesia in Breast Quadrantectomy: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Female gender; age between 18 and 75 years; unilateral breast quadrantectomy or sectorectomy with or without axillary lymphadenectomy; signed informed consent form; elective surgery	Known allergy or hypersensitivity to local anesthetics such as ropivacaine or related agents; infection at the puncture site; coagulopathy or use of anticoagulants that contraindicate regional anesthesia; previous breast surgery; patient refusal to participate in the study; cognitive or psychiatric disorders that impair understanding of the Visual Analogue Scale; bilateral or radical breast surgery; BMI greater than 40 kg/m²; body weight below 37.5 kg	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:26
RBR-2q63v4h	Bacteria-produced dressing for treating wounds in diabetic patients	Not yet recruiting	Intervention	2025-11-14	<NULL>	<NULL>	8510	POLYTISSUE film associated with bacterial cellulose hydrogel for the treatment of venous ulcers in diabetic patients	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Universidade Federal de Alagoas (UFAL)	<NULL>	<NULL>	<NULL>	Adults with a diagnosis of non-infected venous ulcer in the granulation phase; with or without diabetes.	Pregnant women; allergy to the compound; venous ulcers resulting from trauma or any other non-chronic superficial skin lesions; significant systemic infection; cognitive deficit that prevents participation in the research; voluntary request to withdraw from the research.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:31
RBR-10q4syp6	How eating functional foods can help people living with HIV to improve their metabolism and nutrition	Not yet recruiting	Intervention	2025-11-13	<NULL>	<NULL>	8513	Repercussions Metabolic and Nutritional in HIV-Infected individuals: effectiveness of consumption of functional foods	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Universidade Federal do Rio de Janeiro - UFRJ-Macaé	<NULL>	<NULL>	<NULL>	Adults with positive HIV serology; of both sexes; aged over 18 and under 60 years; undergoing antiretroviral therapy; registered at the outpatient clinic of the Specialized Care Service of Macaé, between 2016 and 2025; who accept nutritional care and agree to sign the Informed Consent Form, as approved by the Ethics Committee of Macaé.	Pregnant women; children and adolescents; patients over 60 years of age; people with negative HIV serology; those who do not sign the Informed Consent Form and are in PHASE II of the study; individuals who do not comply with the established period for ingestion of the product (bread enriched with organic flaxseed); those who are using medications for dyslipidemia and glucocorticoids; those who have a diagnosis of lactose intolerance, egg protein intolerance and/or gluten intolerance.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:33
RBR-3vn2r5y	Prevalence of major depressive disorder and treatment-resistant depression in the mental health reference service of Araraquara	Not yet recruiting	Observational	2025-11-13	<NULL>	<NULL>	8514	Prevalence of major depressive disorder and treatment-resistant depression and potential associated factors: a cross-sectional study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Faculdade de Ciências Farmacêuticas do Câmpus de Araraquara da Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Patients treated by the Araraquara Centro de Referência de Saúde Mental do Adulto de Araraquara &quot;Dr. Ubirajara Caldas&quot; (CRASMA-A) and the Centro de Atenção Psicossocial  (CAPS-2); age 18 or older; diagnosed with depression according to the 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11) and the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); using at least one medication to treat depression	There is no exclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:34
RBR-99t5x37	Parasternal block with local anesthetic in cardiac surgery via sternotomy	Not yet recruiting	Intervention	2025-11-13	<NULL>	<NULL>	8515	Superficial parasternal block with 0.2% ropivacaine versus 0.4% ropivacaine in patients undergoing cardiac surgery via sternotomy: a randomized, double-blind, non-inferiority clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 18 and 75 years; body weight greater than or equal to 55 kg; scheduled for elective myocardial revascularization or valve replacement procedure via sternotomy; surgeries involving cardiopulmonary bypass (CPB); having provided written informed consent	Chronic opioid user, defined as more than 3 months of opioid use (excluding tramadol); undergoing thoracic incisions other than sternotomy, excluding chest drain insertion or other incisions for vascular graft harvesting; undergoing emergency surgery, heart transplantation, or surgery without the need for cardiopulmonary bypass; having undergone previous sternotomy; presence of easily detectable cognitive impairment; presenting contraindications to parasternal block analgesia, including coagulation disorders, infection, or malignancy at the puncture site; allergy to the local anesthetic used	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:35
RBR-8ks2vwn	Enavogliflozin PK/PD profile evaluation in healthy brazilian subjects	Not yet recruiting	Intervention	2025-11-12	<NULL>	<NULL>	8517	A phase I, single-center, double-blind, randomized, parallel, placebo-controlled clinical study to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability after a single dose and multiple doses of 0.3 mg, 0.6 mg, and 1.2 mg Enavogliflozin in healthy adult participants of both sexes - SYN 374.002.24 / AC2025-PK/PD-105-1 - ENVLO	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Synvia Laboratórios e Toxicologia Ltda.	<NULL>	<NULL>	<NULL>	Participants must be Brazilian and have Brazilian ancestry (i.e., Brazilian parents and grandparents). They may be male or female, aged between 18 and 55 years, with a body weight ranging from 60 to 100 kg and a body mass index (BMI) between 18.5 and 30 kg/m². They must be in good health, as determined by the absence of significant findings in medical history, physical examination, laboratory tests, vital signs measurements, and electrocardiogram results. Participants must be able to read, understand, and agree to take part in the study by signing the informed consent form (ICF) approved by the ethics committee. They must also agree to comply with the planned study procedures and attend all scheduled visits. Female participants must either have no potential for pregnancy—defined as postmenopausal women (with 12 months or more of amenorrhea) or those who have undergone surgical sterilization—or, if male or female with reproductive potential, must agree to use a reliable contraceptive method	"&quot;Participants must not belong to a vulnerable group or have difficulty swallowing solid-form medications. They must not have used any medication (including herbal remedies) within 14 days prior to hospitalization, except for contraceptives or cases where, based on the drug’s half-life and/or active metabolites, complete elimination can be assumed or, at the investigator’s discretion, the medication does not interfere with the pharmacokinetics or analytical phase of the investigational drug. They must not have used dietary supplements, including herbal or vitamin supplements, within 7 days prior to hospitalization, nor calcium or vitamin D supplements within 14 days prior. They must not have received any vaccine dose within 7 days prior to hospitalization, nor undergone treatment with any drug known to have well-defined toxic potential to major organs within the 3 months prior to the study. Participants must not have taken part in any experimental study or ingested any investigational drug within 12 months prior to the start of this study, nor have been hospitalized for any reason within 8 weeks prior to the hospitalization period.
Participants must not have a history of hepatic, gastrointestinal, or other conditions that may interfere with the absorption, distribution, metabolism, or excretion of the drug. They must not have a history of renal, urinary, respiratory, hematologic, cardiac, endocrine, gastrointestinal, neurological, neoplastic, or psychiatric diseases considered clinically significant by the investigator. They must not have a history of cardiac surgery (any type), renal surgery (removal or agenesis), gastrointestinal surgery (partial or total removal of the esophagus, stomach, duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, sigmoid colon, or rectum), or surgery involving the liver or pancreas. Participants must not present any current, acute, or chronic symptoms or illnesses under treatment or follow-up that are considered significant by the investigator. They must not have a QTc interval greater than 450 ms (for males) or greater than 470 ms (for females), confirmed by repeat testing, or electrocardiographic findings deemed unsuitable for study participation by the physician. They must not have systolic blood pressure &lt; 90 mmHg or &gt; 150 mmHg, or diastolic blood pressure &lt; 60 mmHg or &gt; 100 mmHg during the screening visit after sitting for at least 5 minutes (and no more than 20 minutes) in a quiet, stress-free environment. Participants must not present AST or ALT results equal to or greater than 1.5 times the upper limit of the reference range, nor have laboratory test results outside reference values unless deemed not clinically significant by the investigator. They must not have lab results that, in the physician’s judgment, compromise the participant’s safety. They must not be breastfeeding, pregnant, or have a positive pregnancy test. They must not test positive on a rapid alcohol detection test or on a preliminary drug test for amphetamines/methamphetamines, opioids/morphine, cannabis/THC, cocaine/benzoylecgonine, and/or benzodiazepines. Participants must not be smokers (those with a history of smoking may be included if they have abstained for at least 3 months prior to the study). They must not have a history of illicit drug abuse or be regular alcohol consumers. Women must not consume more than 4 alcoholic drinks in a single day or more than 8 drinks per week, and men must not consume more than 5 drinks in a single day or more than 15 drinks per week. They must not have consumed alcohol or drugs within 48 hours prior to hospitalization. They must not habitually consume more than 5 cups of coffee or tea per day, nor have ingested foods or beverages containing xanthines within 48 hours prior to hospitalization. They must not have consumed grapefruit, grapefruit juice, or grapefruit-containing products within 14 days prior to hospitalization until discharge from the research center, nor be unable to abstain from grapefruit products during the study period. Participants must not have engaged in intense physical exercise within 48 hours prior to hospitalization, nor have unusual or restrictive dietary habits, as determined by the investigator. They must not have donated or lost 450 mL or more of blood in the past 3 months, nor more than 1500 mL in the past 6 months. They must not have difficulty ingesting approximately 200 mL of water in the morning. They must not have any condition that prevents participation in the study, as determined by the investigator. Finally, they must not have hypersensitivity or a history of hypersensitivity to SGLT2 inhibitors, similar compounds, or other medications (e.g., aspirin, antibiotics, heparin), as determined by the physician"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:38
RBR-35gv9ct	Mindful eating intervention in university students	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8525	Effectiveness of a Mindful Eating intervention on eating behavior and body assessment of university students with symptoms of binge eating	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Be a student, regardless of age; regardless of gender; be regularly enrolled in an undergraduate program; own an electronic device (computer, tablet, or smartphone) and have internet access; present symptoms of Binge Eating Disorder (BED) identified by the Binge Eating Disorder Scale (BEDS), with a score greater than or equal to 17	Being pregnant; Having a physical disability or other condition that makes it impossible to obtain anthropometric measurements; Having a diagnosis of severe cognitive or mental disorders, such as schizophrenia or other psychotic disorders; Having a diagnosis of anorexia nervosa or acute depression for less than six months; be using medications or substances that cause loss of attention and cognitive concentration, such as anxiolytic drugs; be a regular practitioner (at least once a week in the last six months) of meditation, yoga, or mindfulnes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:46
RBR-49fgk6d	Nordic or Conventional Walking: which is more effective for people with knee osteoarthritis and metabolic risk?	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8528	Efficacy of Nordic Walking versus Conventional Walking in individuals with knee Osteoarthritis and Metabolic Risk: A pragmatic randomized clinical trial	<NULL>	1-2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal de Santa Catarina- UFSC	<NULL>	<NULL>	<NULL>	Clinical diagnosis of knee osteoarthritis according to the guidelines of the National Institute for Health and Care Excellence (NICE), which include being 45 years or older, having joint pain related to physical activity, and not presenting morning joint stiffness or presenting morning stiffness lasting less than 30 minutes; higher level of pain reported in the knee compared to other joints; waist circumference greater than 88 centimeters for women or greater than 102 centimeters for men, characterizing increased metabolic risk according to the World Health Organization guidelines	Cognitive deficits that impair understanding of instructions or provision of informed consent; inability to walk independently for at least 15 minutes; clinical conditions that contraindicate regular physical exercise; previous orthopedic surgeries in the lower limbs, pelvis, or spine within the last 18 months, including arthroplasty such as knee or hip replacement, arthroscopy, osteotomy, ligament or meniscal repairs, fracture fixation, spinal decompression or fusion; surgeries with relevant impact on body weight or metabolism such as bariatric surgery performed within the last 18 months; any surgery within the last 6 months that required immobilization for more than 14 consecutive days, restricted physical activity, or required supervised rehabilitation; other surgical procedures, at the discretion of the study coordination, that may interfere with functional capacity, pain, or muscle performance; intra-articular injection in the knee within the last 6 months; musculoskeletal trauma in the lower limbs within the last 6 months; history of knee arthroplasty regardless of date; minor outpatient procedures will not be considered exclusion criteria, such as simple dental surgeries including root canal treatment, cleaning, or simple extractions, minor dermatological surgeries such as removal of cysts or lipomas, low-impact ophthalmologic surgeries such as cataract surgery, diagnostic procedures such as colonoscopy or endoscopy, insertion of an intrauterine device (IUD) or minor gynecological procedures, provided that they did not restrict physical activity for more than 7 days in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:49
RBR-3jk98z7	Effects of Blood Restriction Muscle Training associated with Light Therapy	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8529	Effects of Blood Flow Restriction Training associated with Photobiomodulation Therapy	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Fundação do ABC	<NULL>	<NULL>	<NULL>	Men and women; Healthy individuals; Aged between 18 and 30 years; Body mass index classification up to 30 kilograms per square meter	Individuals with musculoskeletal injuries undergoing treatment or with a history of upper limb surgery; Clinical manifestations that prevent exercise, such as changes in blood pressure, heart rate, and/or respiratory rate	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:50
RBR-8ppyzb2	Clinical study of the combination of paracetamol, phenylephrine and chlorpheniramine in the treatment of flu and common cold.	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8531	Efficacy and safety study of the combination of paracetamol, phenylephrine and chlorpheniramine in the symptomatic treatment of flu and common cold.	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Scentryphar Pesquisa Clínica Ltda	<NULL>	<NULL>	<NULL>	Patients capable of understanding the nature of the study, willing to comply with all study procedures, and who agree to provide signed informed consent; Male or female, aged greater than or equal to 18 years and less than or equal to 65 years at the time of signing the informed consent; Patients must have a cold or flu-like illness diagnosed by a healthcare professional at the study center, with the following symptoms having started within 72 hours before the screening/baseline visit: nasal congestion, sneezing, and runny nose. The severity of general nasal symptoms must be at least moderate on a five-point Likert-type symptom severity scale (0 = no symptoms; 1 = mild; 2 = moderate; 3 = severe; 4 = very severe); Patients must also have non-nasal cold symptoms (sore throat, headache, cough, myalgia, and fever). The severity of pain symptoms must be at least moderate on a five-point Likert-type symptom severity scale (0 = no symptoms; 1 = mild; 2 = moderate; 3 = severe; 4 = very severe); Patients must have a sum of physician assessment of signs scores of at least 5	Pregnant or breastfeeding women (lactating women); Women who do not agree to use temporary contraceptive methods; Men who do not agree to use temporary contraceptive methods (considering the short treatment time of this study), such as barrier methods, during the study, except for those who are surgically sterile (vasectomy), or who have female partners who use effective contraceptive methods, or surgically sterile partners, or partners who have been menopausal for at least 1 (one) year, or participants who declare that they do not engage in sexual practices or engage in them in a non-reproductive manner; History of or known hypersensitivity to any of the study medications, excipients, or medications of similar chemical classes; Rapid onset of symptoms that, in the investigator&apos;s opinion, are indicative of severe cases of influenza; Use of alcohol or illicit drugs; Use of monoamine oxidase (MAO) inhibitors or barbiturates; Perennial or seasonal allergic rhinitis confirmed at screening; History of or chronic respiratory disease (within the past 5 years); Presence of nasal polyps, significant nasal septum deviation, or any other anatomical abnormality affecting airflow; Any current acute illness or uncontrolled exacerbation of a chronic disease; Any evidence (within 2 years) of significant cardiovascular, pulmonary, renal, hepatic, gastrointestinal, hematologic, endocrinologic, metabolic, neurologic, psychiatric, or other disease at screening, including hypertension, cardiac arrhythmias, serious organic changes of the heart and blood vessels, uncontrolled thyroid disease, thyrotoxicosis, decompensated diabetes, or benign prostatic hypertrophy, based on the investigators&apos; assessment; Long QT syndrome or QTc greater than 450 msec for men and greater than 470 msec for women at screening/baseline; Clinical evidence of immunosuppression; Clinically relevant chronic or acute infectious diseases or febrile infections within 2 weeks prior to study entry, including bacterial sinusitis within 2 weeks prior to the screening visit/baseline period; Influenza vaccination up to 1 week prior to enrollment; Need for antiviral therapy to treat influenza A or B infection; Need for antibacterial therapy to treat acute respiratory infection; Use of medication to treat conditions acquired prior to enrollment for a period shorter than two time intervals of administration of these medications; Patients using medications likely to interact with phenylephrine and chlorpheniramine (alcohol, opioid analgesics, anticonvulsants, antidepressants (tricyclic monoamine oxidase inhibitors), antihistamines, antiemetics, antipsychotics, anxiolytics and hypnotics, alpha and beta blockers, vasodilators, sympathomimetic agents) and paracetamol (for paracetamol alone: ​​within 24 hours before study drug intake and during the study, also anticoagulants such as warfarin and coumarin, chloramphenicol, probenecid, rifampicin and isoniazid, cholestyramine, metoclopramide, domperidone, zidovudine, didanosine, propantheline) should be excluded; Use of another investigational drug in the period less than one year before enrollment; Any other changes in laboratory tests regarding complete blood count, blood glucose (pre- or postprandial), sodium, potassium, creatinine, total bilirubin, AST, AST, alkaline phosphatase, and γ-GT, which, in the investigator&apos;s discretion, are considered clinically significant; Patient reports consumption of any drug-metabolizing enzyme (e.g., CYP3A4 or other cytochrome P450 enzymes) inducing or inhibiting foods, beverages, or dietary supplements (e.g., broccoli, Brussels sprouts, grapefruit, grapefruit juice, star fruit, St. John&apos;s wort, etc.) within 48 hours prior to the first scheduled administration of the study drug, or is expected to consume such products during the period or at any time throughout the study; Surgery of the gastrointestinal tract that may interfere with drug absorption (note: this is not applicable to minor abdominal surgery without significant tissue resection, e.g., appendectomy or herniorrhaphy)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:52
RBR-5yh9chg	Gingival Healing Response Around Surface-Treated Prosthetic Abutments: A One-Year Clinical Evaluation	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8532	Tissue Repair Analysis at the Interface of Anodized Prosthetic Abutments: A Prospective, Randomized, Controlled Clinical Trial with One-Year Follow-Up	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Centro De Pesquisas Odontologicas Sao Leopoldo Mandic Ss	<NULL>	<NULL>	<NULL>	Patients of both sexes, aged between 18 and 80 years, partially edentulous in the posterior maxilla or mandible; with the absence of at least two teeth, whether contiguous or not; healed ridges that did not require tissue reconstruction for subsequent placement of dental implants; implants installed with primary stability; minimum mucosal thickness at the ridge crest of 2 mm of keratinized tissue height	Patients who require some type of bone prosthesis or advanced surgical procedure to allow for implant placement; with systemic contraindications to the surgical procedure or conditions that interfere with the osseointegration process	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:52
RBR-3b665wc	Heart and Lung Rescue with Rapid Cycles	Not yet recruiting	Intervention	2025-11-10	<NULL>	<NULL>	8535	Cardiopulmonary resuscitation and deliberate practice in rapid cycles	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Fundação Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	The study included education professionals working in state or municipal public schools in the municipalities of Aracaju, Lagarto, and São Cristóvão in the state of Sergipe. Participants must be actively performing their duties at the time of data collection, understand and communicate in Portuguese, have the cognitive and physical capacity to complete the cardiopulmonary resuscitation training steps, and agree to participate in the study by signing the informed consent form	Professionals who are away from their duties due to vacation, leave, or absence during the data collection period will be excluded. Professionals with musculoskeletal conditions that prevent them from performing cardiopulmonary resuscitation maneuvers, such as chest compressions or specific movements required in the simulation, will be excluded. Individuals with cognitive impairment that interferes with understanding the instructions, as well as those who do not complete all stages of the study or refuse to sign the Informed Consent Form, will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:56
RBR-46gd7h3	Acute effect of high-intensity exercise on arterial stiffness in older adults: a randomized crossover clinical trial.	Not yet recruiting	Intervention	2025-11-21	<NULL>	<NULL>	8541	Acute response of arterial stiffness to anaerobic capacity in elderly individuals: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Older adults of both sexes aged 60 to 79 years, physically able to perform moderate to vigorous intensity physical exercise, and available to participate in the project’s scheduled activitie	The criteria that prevent participation are individuals with debilitating neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, or plegias; those with reduced intellectual capacity; individuals with severe cardiovascular diseases, including heart disease, arrhythmias, or uncontrolled hypertension; persons with medical contraindications to physical exercise, such as recent surgeries, joint prostheses, or musculoskeletal injuries; participants simultaneously enrolled in other clinical studies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:59
RBR-4x4xj3b	Immediate effect of hypnosis on low back pain	Not yet recruiting	Intervention	2025-11-21	<NULL>	<NULL>	8542	Immediate analgesic effect of a single hypnosis session in individuals with chronic low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Participants experiencing chronic nonspecific low back pain; pain and discomfort localized below the costal margin and above the inferior gluteal folds, with or without leg pain; symptom duration of at least 3 months; average pain intensity ≥ 3 on the 0–10 numerical pain rating scale at the time of assessment; able to understand Portuguese through both written and audio materials	Participants with specific spinal pathologies (e.g. tumor, infection, fracture, inflammatory disease); radiculopatia lombar (defined as at least two of the following signs: muscle weakness, altered reflexes, or sensory loss in the distribution of the same spinal nerve); diagnosis of neurological, renal, cardiovascular, psychiatric conditions; pregnancy or postpartum period of less than 3 months; cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:15
RBR-2ynphzg	Assessment of skin irritation after use of a medical device	Not yet recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8549	Orc_147832_25-0732-01_assessment of primary dermal irritability, cumulative dermal irritability and dermal sensitization (hript)	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-24	Medcin Pesquisa Clínica Ltda	<NULL>	<NULL>	<NULL>	Participants of both sexes aged 18 to 70 years; phototype: I, II, III and IV, according to the adapted Fitzpatrick scale; intact skin in the application area; agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consent and signing of the informed consent form	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs 30 days prior or immunosuppressive drugs for up to three months before selection; immunosuppression due to active drugs or diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the evaluation or during the study period; anticipated sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermatographism; use of oral or topical treatment with vitamin A acid or its derivatives up to 1 month before the start of the study; aesthetic or dermatological treatment on the body within 3 weeks before selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitivity to topical products; active skin pathologies that may interfere with the study results; skin reactivity; use of new medications during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in the study product; history of non-adherence or unwillingness to adhere to the study protocol; Medcin or sponsoring company employees involved in the study, or a close family member of an employee involved in the study; other conditions considered by the investigator as reasonable grounds for disqualification from study participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:09
RBR-6hdns7j	Vagal auricular stimulation for somatosensory tinnitus in patients with temporomandibular dysfunction	Not yet recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8551	Non-invasive brain stimulation in neurological conditions	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Participants aged 18 years or older, of both genders, with temporomandibular dysfunction according to the Diagnostic Criteria, with alterations in heart rate variability in at least 2 of the 3 time points of the orthotest, and with somatosensory tinnitus	Individuals with neurological, cognitive, or linguistic impairments will be excluded from the study; those who do not use the oral language code; those with tonal and vocal audiometry outside the normal limits; individuals with rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis; those with cardiac arrhythmia or other cardiovascular conditions using beta-blockers; pregnant women or women in the puerperium or postpartum period; patients diagnosed with cancer, epilepsy, skull, cervical or rib fractures, and severe osteoporosis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:11
RBR-339tjg8	The effects of parasacral nerve electrotherapy combined with behavioral changes and bladder retraining on the quality of life of women with overactive bladder: a randomized controlled clinical trial	Not yet recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8552	The effects of adding Transcutaneous Electrical Stimulation of the Parasacral Nerve to Behavioral Therapy and Bladder Training on the Quality of Life of women with Overactive Bladder: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Women over 18 years of age, with complaints of overactive bladder with Urgency Urinary Incontinence; who obtain a score greater than or equal to 8 in the Overactive Bladder Validated 8 (OAB-V8) questionnaire, who have had sexual intercourse	Not knowing how to read and not being able to answer the questionnaires; presenting symptoms of urinary tract infection on the day of the assessment; not having undergone corrective surgery for urinary incontinence; not having undergone previous pelvic radiotherapy; having neurological disease; not undergoing pharmacological and physiotherapeutic treatment for overactive bladder; presenting only Stress Urinary Incontinence (SUI), having symptoms of overactive bladder but not losing urine; grade 3 anterior and posterior wall prolapse	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-6syd77s	Inhalation of chamomile aroma for pain and anxiety during arterial sheath removal after cardiac surgery	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8557	Effect of aromatherapy with Matricaria chamomilla essential oil on pain and anxiety in the context of femoral arterial sheath removal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Rodrigo Assis Neves Dantas Dantas	<NULL>	<NULL>	<NULL>	Inclusion criteria will be based on patients aged 18 years or older; admitted to the Hemodynamics Unit of Heart Hospital of Natal for first-time ACTP-type cardiovascular surgical procedures requiring removal of an arterial introducer via the femoral approach; and undergoing an elective cardiovascular procedure.	Exclusion criteria include patients with chronic pain; continuous use of analgesics, anxiolytics, or antidepressants; neurological and/or cognitive problems that compromise comprehension and use of the scale at the appropriate time; olfactory impairment or respiratory disease; and allergies or sensitivity to chamomile.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:16
RBR-6g7wmqp	Effects of Pre-Load with Hydrolyzed Collagen on Blood Sugar and Health in Patients with Obesity and Diabetes	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8558	Acute and Chronic Effects of Hydrolyzed Collagen Pre-load on the Modulation of Glycemia, Hormonal, Inflammatory, and Metabolic Profiles in Patients Living with Obesity and Pre-diabetes or Type 2 Diabetes: A Randomized, Double-Blind Crossover Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	Adults over 18 years of age, able to provide free and informed consent; Diagnosis of Obesity or Overweight and Glycemic Dysregulation: Body Mass Index (BMI) between 25 and 39.9 kg/m² and/or waist circumference &gt; 88 cm for women and &gt; 102 cm for men, and/or Waist-to-Hip Ratio (WHR) &gt; 0.5; Pre-diabetes: Fasting glucose between 100-125 mg/dL OR Glycated Hemoglobin (HbA1c) between 5.7-7.0% OR Oral Glucose Tolerance Test (OGTT) with 2-hour post-load glucose between 140-199 mg/dL, without medication use or only on metformin; Type 2 Diabetes Mellitus (T2DM): Individuals using only stable-dose metformin or lifestyle modifications for glycemic control; Stable weight (fluctuation of ± 3 kg) in the last 3 months before screening	Smokers; Type 1 or Type 2 Diabetes Mellitus using insulin, sulfonylureas, Glucagon-like Peptide-1 agonists, or other antidiabetic medications that could mask the effect of the intervention (except metformin, if included in the inclusion criteria); Glycated Hemoglobin &gt; 8.0%, indicating inadequate glycemic control that would require more intensive pharmacological interventions and could mask the effect of the nutritional intervention; Severe clinical conditions such as chronic kidney disease (stage 3 or higher, estimated glomerular filtration rate &lt; 60 mL/min/1.73m²), significant chronic liver disease (Aspartate Aminotransferase or Alanine Aminotransferase &gt; 3x the upper limit of normal), severe cardiovascular disease (myocardial infarction, stroke in the last 6 months, decompensated heart failure, unstable angina), active inflammatory bowel diseases (Crohn&apos;s Disease, Ulcerative Colitis), autoimmune diseases, except Hashimoto&apos;s, cancer undergoing treatment in the last 5 years; Use of Concomitant Medications: Systemic corticosteroids, medications that significantly affect glucose metabolism or gastrointestinal function (e.g., SGLT2 inhibitors, glitazones, some psychotropics); Collagen supplements, in the 3 months prior to the study; Regular use of laxatives or other supplements (e.g., other high-dose fibers, specific probiotics/prebiotics) that could impact intestinal health or glucose metabolism, and that cannot be discontinued during the study; Antibiotics in the last 3 months before the intervention; Surgical Conditions: History of bariatric surgery or other gastrointestinal surgeries that significantly alter absorption or intestinal transit; Specific Conditions: Pregnancy or breastfeeding, eating disorders (anorexia, bulimia nervosa), alcohol or drug abuse, known allergy or intolerance to any component of the test product or placebo; Inability to Consent: Any physical or mental condition that prevents understanding and providing informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:18
RBR-6yysksv	Effects of Yoga on the lives of caregivers of children with Autism in Acre	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8562	Yoga as an Intervention in the Quality of Life and Emotional States of caregivers of children with Autism Spectrum Disorder in Acre	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal do Acre	<NULL>	<NULL>	<NULL>	Caregivers of any gender; aged 18 years or older; whose children (here considered to be between 2 and 14 years old) are diagnosed with Autism Spectrum Disorder using the classification indicated by ICD-10 with a medical report dated at least six months prior; receiving regular care at the care facility for at least six months; the caregiver must serve as the primary caregiver	Presence of health conditions, both physical and mental, that impair the individual&apos;s ability to complete questionnaires or respond to interviews independently will be considered an exclusion criterion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:22
RBR-8d4r7gv	Study 1 - Therapeutic and Ergogenic effects of the Regional Herb Tereré on exercise tolerance in well-trained female runners	Not yet recruiting	Intervention	2025-11-25	<NULL>	<NULL>	8566	Therapeutic and Ergogenic effects of a Regional Extract: TERERÉ	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Universidade Federal de Mato Grosso do Sul	<NULL>	<NULL>	<NULL>	Well-trained competitive or recreational female runners; experienced in endurance; healthy; aged 16 years or older; active in the modality for at least 3 years; engaged in regular endurance training (at least 4 times per week); and with familiarity in road races of at least 10,000 m	Presenting injuries during the study period; experiencing adverse effects from caffeine consumption; reporting cardiovascular diseases or chronic non-communicable diseases (NCDs) and any other health conditions; use of medications for cardiac, pulmonary, thyroid, antihypertensive, endocrinological, or neuromuscular conditions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:23
RBR-959mr56	Supplement for patients undergoing treatment for squamous cell carcinoma of head and neck	Not yet recruiting	Intervention	2025-11-24	<NULL>	<NULL>	8575	Dietary Supplement for Patients Undergoing Treatment for Head and Neck Squamous Cell Carcinoma	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-06	Universidade Estadual de Montes Claros	<NULL>	<NULL>	<NULL>	Patients over 20 years of age. Both sexes. Diagnosis and treatment of head and neck cancer in a hospital participating in the study. Participation voluntarily authorized through signing of the Free and Informed Consent Form. Presence on the scheduled days for data collection and nutritional assessment	Patients who discontinue cancer treatment or do not follow the instructions related to the use of the dietary supplement. Patients with allergies or intolerance to any ingredient of the formula. Diabetic patients. Patients using feeding tubes. Oncology patients with neoplasms in anatomical sites other than the head and neck. Patients not identified by the researchers. Patients who refuse to participate or have not signed the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:55
RBR-65frmbm	&quot;Effects of Brain Stimulation as Therapeutic Support in Body Control Issues in Individuals with Brain Differences: a Randomized Study&quot;	Not yet recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8581	Effects of using Transcranial Direct Current Stimulation as a therapeutic support tool in Autonomic Dysfunction in Neurodivergent individuals: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-30	Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco	<NULL>	<NULL>	<NULL>	Patients treated at the neuromodulation clinic located at the IFPE Campus Pesqueira, referred by the Association of People with Special Rights (PODE), the Psychosocial Care Center (CAPS), and the Basic Health Unit (UBS), all located in the city of Pesqueira-PE, with neurological reports indicating autism spectrum disorder, attention deficit hyperactivity disorder, and other neurodivergences.	Participants with epilepsy, those using anticonvulsant medications and/or suffering from sleep deprivation, patients with metallic implants in or near the head (e.g. cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, projectile fragments, jewelry, and hair clips), patients with cardiac pacemakers, stents, or other active devices whose interaction with the electric field may interfere with their functioning, patients with eczema on the head, patients with inconclusive diagnostic outcomes, therapy abandonment, and hospitalization	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-7j8fby5	The effect of Beta-hydroxy-beta-methylbutyrate supplementation on muscle mass and tumor progression in Esophageal Cancer patients undergoing Chemoradiotherapy	Not yet recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8582	Use of ß-Hydroxy ß-Methylbutyrate (HMB) as a supplement in the maintenance of muscle mass and Tumor progression in patients with Esophageal Cancer undergoing Chemoradiotherapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	<NULL>	<NULL>	<NULL>	Adult patients - 18 years of age or older; of both sexes; with a confirmed diagnosis of stage III or IV esophageal cancer, without metastases; who are undergoing concomitant chemoradiotherapy; exclusively using enteral nutrition; participants must have adequate physical and cognitive conditions to perform the proposed tests; and agree to participate voluntarily in the study by signing the Informed Consent Form	Individuals with distant metastases; senility or any condition that causes an inability to understand the procedures; inability to adhere to the protocol or refusal of treatment; history of previous thoracic radiotherapy; presence of active collagenosis; clinical conditions that prevent safe participation in assessments; use of parenteral nutrition or exclusively oral feeding; as well as concomitant participation in other clinical trials that may interfere with the results	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-5j7dqtq	Evaluation of the effectiveness of daily-use toothpastes on gingival health	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8583	Evaluation of the effectiveness of commercially available toothpaste on periodontal health - Study protocol for a randomized, controlled, blinded clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Volunteers in good general health; aged between 18 and 30 years; absence of motor, comprehension, or cognitive difficulties that could impair oral hygiene	Volunteers with active dental caries with a cavity exposing the dentin on the teeth used for the simplified oral hygiene index; teeth with developmental defects or dental crowding; periodontal disease with tooth mobility greater than 2mmor periodontal pocket depth greater than 5mm; parafunctional habits such as bruxism or nail-biting, presence of active clasps for removable partial dentures or use of orthodontic appliances; use of antibiotics in the last six months; performance of non-surgical periodontal therapy in the last six months; systemic conditions that may interfere with disease progression or treatment response, such as diabetes or immunological disorders; need for antibiotic prophylaxis for routine dental procedures; prolonged use of anti-inflammatory drugs; smoking; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-6p9769y	Effects of cancer treatment on oral health and ways to manage them	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8584	Impact of oncological treatment on oral health: side effects and therapeutic alternatives	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-20	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients over 18 years of age, of both sexes, with a diagnosis of head and neck cancer who will begin oncologic treatment. Participants must agree to use the alternative mouth rinse containing green tea and hyaluronic acid from the New Care line. They must also authorize clinical evaluations and weekly follow-ups during treatment and in the post-radiotherapy period. All participants will be required to read, understand, and sign the Informed Consent Form, confirming their willingness to participate in the study and allowing the collection and analysis of clinical data	Patients who have a history of allergy or hypersensitivity to any component of the alternative mouthwash (green tea, hyaluronic acid, and other ingredients of the New Care line); who do not agree to participate in clinical evaluations; who do not agree to provide their personal information; who do not accept the conditions of the Informed Consent Form; or who are severely debilitated and not fit to undergo evaluations and follow-up after the end of radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-42t9xmy	Effect of an Abdominal Strengthening Exercise Protocol in university students with Chronic Non-Specific Low Back Pain: A randomized clinical trial	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8585	Development and validation of a CORE Stabilization Exercise Protocol in university students with Chronic Non-Specific Low Back Pain: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de Alfenas- UNIFAL-MG	<NULL>	<NULL>	<NULL>	The criteria will be men and women aged between 18 and 60 years; who have low back pain with or without back stiffness for more than 3 months; self-reported pain at a score of 3 or more on the Visual Numerical Scale (VNS); willing to participate and be randomly allocated to the study groups; availability of time to carry out the intervention in the space provided by the Faculty of São Lourenço	Exclusion criteria include fractures or surgery of the spine or lumbar region; history of spinal cord trauma; tuberculosis; cancer; pregnancy, breastfeeding, or planning a pregnancy during the study period; rejection, fear, or unavailability of the proposed interventions; having undergone any therapy or other spinal treatment in the last three months prior to the study; receiving physical therapy concomitantly with the proposed intervention; patients with psychiatric conditions accompanied by difficulty understanding; severe systemic disease; inability to complete research questionnaires; and ongoing use of medications such as corticosteroids, muscle relaxants, or analgesics	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-3b2cggn	Social skills training with RPG for autistic adults: a clinical trial	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8590	Role-playing game–based social skills training for adults with autism spectrum disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	individuals of both gender between 18 full years and 35 years of age not yet completed with a prior clinical diagnosis of autism spectrum disorder, according to the criteria of the diagnostic and statistical manual of mental disorders, fifth edition; and who score 60 points or higher on the self-report version of the social responsiveness scale, second edition	illiterate individuals; having intellectual disability with a total intelligence quotient score less than or equal to seventy points assessed through the wechsler abbreviated intelligence scale; having any of the following current mental conditions identified by the structured clinical interview for the disorders of the diagnostic and statistical manual of mental disorders, fifth edition: current manic episode, current hypomanic episode, psychotic symptoms, psychotic disorders, substance use disorders, or risk of suicide; having a moderate or severe depressive episode according to the hamilton depression scale of seventeen items with a score greater than or equal to eighteen points, or moderate or severe anxiety according to the hamilton anxiety scale of fourteen items with a score greater than or equal to eighteen points; participating in another psychotherapeutic intervention during the course of the study or, if receiving a psychopharmacological intervention, having any change in dose or medication within the three months prior to or during the course of the study; attending less than seventy-five percent of the intervention sessions or of the control sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-2jtk8cn	Effects of Brazil nut supplementation on inflammation and oxidative stress in patients with kidney issues on peritoneal dialysis	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8593	Effects of Brazil Nut Supplementation on inflammation and oxidative stress in patients with Chronic Kidney Disease undergoing Peritoneal Dialysis	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Hospital Universitário Pedro Ernesto	<NULL>	<NULL>	<NULL>	patients with chronic kidney disease undergoing peritoneal dialysis for at least three months; both sexes; age over eighteen years; regular nutritional follow up at the peritoneal dialysis outpatient clinic of pedro ernesto university hospital; conducted every two months	smokers; pregnant women; lactating women; use of antiinflammatory drugs; individuals who are allergic, intolerant, or have a habitual intake of brazil nuts; infectious diseases, liver diseases, aids, and cancer; use of antioxidant supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-76yd7ph	Effect of high intensity interval training on 24-Hour Central Pressure	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8596	Effects of different types of physical exercise on blood pressure, arterial pressure, and indicators of sarcopenia in hypertensive adults and elderly individuals	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-06	Centro de Ciências da Saúde da Universidade Estadual de Maringá	<NULL>	<NULL>	<NULL>	Age between 40 and 79 years; clinical diagnosis of stage I or stage II systemic arterial hypertension confirmed by ambulatory blood pressure monitoring performed within the last six months; regular use of antihypertensive medication; physical and cognitive ability to perform the exercise protocols; signed informed consent form	Inability or refusal to sign the informed consent form; myocardial infarction; revascularization procedures; deep vein thrombosis; stroke or pulmonary embolism in the last twelve months; chronic heart failure class III or class IV according to the new york heart association classification (nyha); unstable arrhythmia; chronic obstructive pulmonary disease requiring corticosteroid therapy or oxygen therapy; renal disease under dialysis treatment; progressive neurological disorders such as parkinson disease or multiple sclerosis; cancer under treatment in the last two years; participation lower than seventy five percent of exercise sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-3tb25z8	Comparison of two bone reconstruction techniques in dental implant treatment: Barbell and Titanium-Reinforced Polytetrafluoroethylene Membranes	Not yet recruiting	Intervention	2025-11-29	<NULL>	<NULL>	8598	Barbell Technique versus Titanium-Reinforced PTFE Membranes in Guided Bone Regeneration: a prospective randomized clinical study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Instituto de Ciência e Tecnologia - Campus de São José dos Campos - Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Loss of three adjacent teeth in an atrophic alveolar ridge in the maxilla or mandible, according to the horizontal alveolar changes classification; need for bidirectional horizontal bone augmentation; residual bone height (minimum of 8 mm) at the surgical site; adequate oral hygiene; presence of 2 mm of keratinized tissue in the attached gingiva; aged between 18 and 75 years; both genders	Periodontal or peri-implant diseases; contraindications to surgical procedures; dental implants adjacent to the surgical site; smokers; diabetic patients; history of previous radiotherapy or chemotherapy; use of immunosuppressants, bisphosphonates, or corticosteroid therapy; pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-4zg9nwh	Comparison of three surgical approaches for removal of the right kidney for donation	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8604	Open, laparoscopic, and robotic right donor nephrectomy: a prospective randomized study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Hospital das Clínicas da Faculdade de Medicina da USP - HC FMUSP	<NULL>	<NULL>	<NULL>	Patients aged &gt;18 years. Voluntary living kidney donors approved for transplantation by the institutional medical, ethical, and legal committees	Contraindications to laparoscopic or robotic approaches. Uncontrolled comorbidities. Refusal to provide informed consent. Left kidney donors	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-8q6kj3n	Effects of brain electrical stimulation combined with speech therapy on the voice and speech of individuals with Parkinson’s disease	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8605	Effects of tDCS combined with speech therapy on the voice and speech of individuals with Parkinson’s disease: a randomized clinical trial with follow-up.	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Departamento de Fonoaudiologia	<NULL>	<NULL>	<NULL>	Individuals with a medical diagnosis of Parkinson’s disease, at stages I to IV on the Hoehn &amp; Yahr scale, aged over 18 years, of both sexes; being in the “on” medication state during the collection of voice samples; presenting some self-reported or clinically detected communication complaint related to speech and/or voice, as identified by the evaluator during the initial contact	Individuals with severe cognitive or motor impairments that prevent comprehension and/or proper execution of the proposed exercises; pregnant women; individuals reporting other neurological or psychiatric disorders; history of seizures/epileptic crises; previous laryngeal surgery; or history of head and neck surgery (such as deep brain stimulation). Participants who miss more than one session or experience any serious adverse event will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-5c8chm9	Use of Absorbable Synthetic Membrane in bone regeneration with primary or secondary Closure: a non-inferiority clinical ctudy	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8606	Comparative evaluation of Absorbable Synthetic Membrane in bone regeneration after third molar extraction: randomized clinical study with split mouth design	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Individuals of both sexes aged; between 18 and 40 years old who are in good general health and have bilateral lower third molars with similar positions in the hemi-arches according to the Pell and Gregory classification	Patients who are pregnant or breastfeeding; smokers; patients taking medication that poses a risk for MRONJ; individuals who show signs of infection at the time of the procedure; individuals with a history of pericoronitis in the 7 days prior to the procedure; individuals with decompensated systemic disease; individuals with a previous diagnosis of bone disease; and individuals who have undergone previous radiotherapy or chemotherapy will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-44tvxzn	Evaluation of simulation-based training effectiveness in postpartum infection treatment	Not yet recruiting	Intervention	2025-12-03	<NULL>	<NULL>	8612	Evaluation of simulation-based training effectiveness in Puerperal Sepsis management: a randomized controlled trial with medical students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Medical students enrolled in a mandatory obstetrics rotation; with agreement to participate in the study and signature of the Informed Consent Form	Previous participation in sepsis training within the last 6 months; inability to participate in scheduled assessments; withdrawal from the rotation during the study period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-6yzr9zb	Transcranial Laser in the Treatment of Depression and Related Symptoms	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8614	The impact of Transcranial Laser on Depression, associated symptoms, and biochemical markers: a double-blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Individuals aged 18 to 60 years; both sexes; with depression as measured by achieving the minimum scores on the Patient Health Questionnaire-9 (PHQ-9) for mild or moderate depression	Risk of suicidal ideation; severe depression assessed using PHQ-9 scores; individuals with diseases that may be stimulated by light; immunocompromised individuals; cancer patients; individuals with infectious diseases or in a febrile state; epileptic individuals; pregnant and/or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-7z5pw7y	Effects of Physical Exercise with Electrical Stimulation on the health of elderly individuals with kidney Issues	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8615	Effects of a Physical Exercise protocol with or without Neuromuscular Electrical Stimulation on Dialysis efficiency and functionality in elderly people with Chronic Kidney Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-13	Universidade Comunitária da Região de Chapecó	<NULL>	<NULL>	<NULL>	Older adults of both sexes, aged between 60 and 75 years, undergoing hemodialysis treatment for at least three months, who present hemodynamic and clinical stability confirmed by the following parameters: resting heart rate between 50 and 100 bpm, respiratory rate between 12 and 25 breaths per minute, oxygen saturation greater than 90%, blood pressure between 90/60 mmHg and 160/90 mmHg, and body temperature between 36°C and 37.8°C; laboratory tests performed within the last 30 days showing a minimum hematocrit of 30%, hemoglobin level above 8 g/dL, and platelet count greater than 50,000/mm³; preserved lower-limb muscle strength assessed using the Medical Research Council (MRC) Muscle Strength Scale, with a minimum score of grade 3 for hip flexors, knee extensors, and ankle dorsiflexors; cognitive function will be assessed using the Mini-Mental State Examination (MMSE).	Participants with a diagnosis of cancer or chronic lung disease; those who present musculoskeletal limitations that compromise the execution of the exercise protocol for cycling and strength training or that pose a risk to participant safety, such as in the case of hemodynamically unstable older adults; individuals with a high degree of frailty assessed by the Frailty Scale, without functional independence, using a cutoff point of 5; participants who miss more than three consecutive or alternating sessions; those who present changes in clinical condition that prevent the performance of the physical exercise protocol will have their data excluded from analysis; dialysis fistulas in the lower limbs; very active older adults, assessed using the Short Physical Activity Index (Short IPAQ), to determine the physical activity level of older adults with chronic kidney disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-2pd933q	Effect of Transcranial Magnetic Stimulation (TMS) associated with speech-language pathology treatment in patients with difficulty swallowing after a stroke	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8620	Non-invasive brain stimulation in neurological conditions	<NULL>	n/a, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Stroke less than 3 months ago; both genders; Rankin scale less than 04; presence of oral communication and/or swallowing disorders; diagnosis of some neurological condition; age over 18 years	Require respiratory support; having magnetic material in the skull or a cardiac pacemaker; epilepsy or a history of seizures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-786rf7z	Brazilian Red Propolis Gel for Oral Mucositis from Chemotherapy	Not yet recruiting	Intervention	2025-12-05	<NULL>	<NULL>	8621	Clinical and in vitro evaluation of a brazilian red propolis gel in patients with oral mucositis induced by antineoplastic chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Fundação Hospital Estadual do Acre - Fundhacre	<NULL>	<NULL>	<NULL>	Individuals of both sexes, aged 18 to 70 years, who started chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and docetaxel and presented grade 1 or higher mucositis	Patients with mandibular immobilization or mechanical fixation that prevents visualization of the oral cavity; indigenous patients; foreign patients; patients allergic to propolis, pollen, or with allergic predisposition or atopy to components of bee honey; patients with concomitant inflammatory or degenerative oral disease; patients undergoing chronic therapy with steroids or immunosuppressants; unconscious or sedated patients	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3t7by45	Comparing treatments for fluid in the lungs: which is most effective?	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8624	CAPE-CHOICE: Comparative Results of Vasodilatory Strategies in Acute Pulmonary Edema	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Santa Casa de Misericórdia da Bahia	<NULL>	<NULL>	<NULL>	Patients with diagnosis of acute pulmonary edema in the emergency unit requiring vasodilator; age 18 years or older; both genders	Patients under 18 years of age; patients with cardiogenic shock; patients with acute coronary syndrome; patients with contraindication to any of the drugs; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-68pry5j	How a Body Vibration Exercise Program Can Help Seniors Reduce the Risk of Falls and Improve Strength, Balance, and Fitness	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8627	Effect of Systemic Vibratory Therapy associated with a Physical Activity Program in Elderly Individuals on the Risk of Falls, Balance, Physical Conditioning and Neuromuscular Variables: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Sociedade Unificada  de Ensino Augusto Motta	<NULL>	<NULL>	<NULL>	Older adults aged sixty years or older. both sexes. participants regularly enrolled in the Open University for Older Adults of the Augusto Motta University Center. ability to walk independently with or without an assistive device. availability to attend all intervention sessions. preserved cognitive ability to understand and follow instructions	Previous diagnosis of disabling neurological diseases. severe musculoskeletal disorders that prevent exercise performance. presence of a cardiac pacemaker or any implanted electronic device. recent orthopedic surgery in the lower limbs within the last six months. decompensated cardiovascular conditions. use of medications that significantly affect postural control. uncontrolled vertigo or vestibular disorders. medical conditions that contraindicate exposure to mechanical vibration	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-6h6k6mt	How metformin use may influence bone marrow fibrosis	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8628	Evaluation of the effects of metformin treatment on the process of myelofibrosis	<NULL>	2-3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Centro de Hematologia e Hemoterapia da Unicamp – Hemocentro da UNICAMP	<NULL>	<NULL>	<NULL>	Eligible patients will be those diagnosed with myeloproliferative neoplasm (MPN) according to WHO criteria confirmed by at least two independent specialists, diagnosed with primary myelofibrosis (PMF) or transformation to secondary myelofibrosis (post-PV or post-TE), confirmed by bone marrow biopsy, and aged ≥ 18 years.	Significant hepatic or renal dysfunction, typically defined as aspartate and alanine aminotransferase levels greater than 2.5 times the upper limit of normal, total bilirubin above 3.0 mg/dL, or serum creatinine above 3.0 mg/dL; hypersensitivity to biguanide, uncontrolled diabetes mellitus, untreated vitamin B12 deficiency, pregnancy, severe psychiatric disorders, and use of anagrelide and/or ruxolitinib in the sixty days prior to screening	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2v7d2v4	Effectiveness of green tea and hyaluronic acid in post-tooth extraction repair in patients undergoing radiotherapy	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8629	Effectiveness of green tea and hyaluronic acid in post-extraction repair in patients undergoing radiotherapy	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-17	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with head and neck cancer, of both sexes, over 18 years of age, who require tooth extractions in the context of radiotherapy treatment, either prior to its initiation or afterwards, due to oral cavity preparation or dental emergencies. All participants must agree to take part in the study and provide their signature on the Informed Consent Form	Severely debilitated patients, those who do not accept or do not sign the Informed Consent Form, pregnant or breastfeeding women, individuals with metallic artifacts that impair tomographic analysis, and those who present periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7r2gzzq	Use of light to treat skin wounds in critically ill patients: a clinical study	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8630	Photobiomodulation in the Treatment of Stage I Pressure Injury in Critically Ill Patients: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-31	Hospital de Clínicas de Porto Alegre	<NULL>	<NULL>	<NULL>	Clinical patients aged 18 to 75 years; regardless of gender; length of stay exceeding 24 hours in the ICU; stage 1 pressure ulcer developed during ICU admission; pressure ulcer identified during ICU admission (acquired in another unit); patients/companions who provide prior authorization through an informed consent form	Patients with coexisting dermatological diagnoses, such as burns, drug-related rashes, dermatitis, psoriasis; patients diagnosed with Fournier&apos;s and Stevens-Johnson syndromes; post-surgical patients (mobility contraindicated); patients with contraindicated changes in position; those who are hemodynamically unstable (patients using extracorporeal membrane oxygenation - ECMO or patients with adult respiratory distress syndrome - ARDS, prone position); patients who have already undergone photobiomodulation in the same injured area	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-648xyqn	The effects of Transcranial Photobiomodulation in children with Autism Spectrum Disorder	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8632	Evaluation of the effects of Transcranial Photobiomodulation in children with Autism Spectrum Disorder: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Children diagnosed with mild Autism Spectrum Disorder (ASD); both sexes; between the ages of 7 and 10; residing in the greater Florianópolis region	Children undergoing treatment with psychotropic medications; diagnosed with another neurological dysfunction; or who have contraindications to laser treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7gtxkpt	Evaluation of products for the treatment of foot wounds in people with Diabetes	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8634	Study of the efficacy and clinical tolerance of the products Cclf2023, Gclf2023, and Ndlf2023 in plantar Ulcers in diabetic patients	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Centro de Pesquisa Clínica do Hospital Universitário da Universidade Federal do Amapá	<NULL>	<NULL>	<NULL>	Adults aged 18 years and older; diagnosed with Type 1 or Type 2 Diabetes Mellitus; HbA1c ≤ 86 mmol/mol (10%) at screening; presence of a full-thickness ulcer below the ankle, with a duration of 6 weeks or more, and measuring between 1.0 and 5.0 cm² after debridement, without exposure of muscle, tendon, or bone; toe pressure ≥ 30 mmHg. Neuropathic and/or ischemic non-infected ulcer, at any stage of healing; change in ulcer area between screening and baseline within −30% to +25%; commitment to required care and no use of unauthorized products; ability to comply with the study protocol and to sign the informed consent form, including authorization for photographs	Pregnant or breastfeeding women; presence of an infected or highly exudative ulcer; indication for amputation; cognitive impairment; recent or current use of immunosuppressants, chemotherapy, or retinoids; unstable chronic diseases; hypersensitivity to components of the product; alcohol or drug abuse. Active Charcot deformity; inability or refusal to follow the protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-95f8kf8	Effectiveness of educational technology on father participation in labor, delivery, and birth	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8636	Effectiveness of educational technology on paternal participation in labor, delivery, and birth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Maternidade Escola Assis Chateaubriand da Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Minimum age of 18 years; be a partner and the companion of the parturient&apos;s choice; first experience in accompanying labor; have completed at least the fourth year of elementary school; and be accompanying nulliparous pregnant women, with a live fetus, at term, with a medical diagnosis of labor or antepartum rupture of the ovular membranes or hypertensive or postpartum syndromes, for induction of labor and who have an indication for vaginal delivery regardless of the obstetric outcome, which may be vaginal or cesarean section	Parturients in the expulsive stage; presenting a compromised physical or mental health condition that makes the research unfeasible; having participated in parenting and/or pregnancy courses; being a health professional; having the presence of doulas; parents with communication difficulties and stillbirth; giving up on continuing to participate in the study after the start of data collection; progressing to labor at the time of the approach; giving up or being unable to answer the proposed questions and stillbirth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-2jrv4ff	Development of Artificial Intelligence Models for predicting the evolution of Aging Patterns using Digital Biomarkers	Not yet recruiting	Intervention	2025-12-10	<NULL>	<NULL>	8641	Development of Artificial Intelligence Models for predicting the evolution of Aging Patterns using Digital Biomarkers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	<NULL>	<NULL>	<NULL>	Participants must be 60 years of age or older, of either sex; have agreed to participate by signing the Informed Consent Form ICF or the Informed Assent Form IAF for individuals with greater difficulty understanding or associated cognitive impairment; and possess cognitive capacity that allows them to perform the tasks	Participants unable to understand and execute the specific instructions and commands of the intervention, including those with cognitive or behavioral deficits that prevent effective interaction with the games and tasks; individuals with severe visual or auditory impairments that prevent interaction with the extended reality interface, or unstable medical conditions that may compromise their safe participation; withdrawal from the study; failure to adapt to the proposed intervention protocol; use of medications or substances that significantly interfere with motor control; consecutive absences or absence from scheduled sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-99tjfz5	Promoting Maternal Mental Health Through the Online PROMATER Program	Not yet recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8644	Promoting Maternal Mental Health: Development and Evaluation of the Online PROMATER Program	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	<NULL>	<NULL>	<NULL>	Brazilian women; age 18 years or older; internet access via computer, smartphone or tablet; pregnant women with more than thirteen weeks of gestation or up to six months postpartum	Current severe psychiatric diagnosis, such as psychotic episode, bipolar disorder in the acute phase or substance use disorder, according to self-report	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-104rgrk4	Recovery of Gait in Patients Who Have Suffered a Stroke Using Robotic Technologies and Brain Stimulation	Not yet recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8646	Neuromodulation with Transcranial Magnetic Stimulation Combined with a Motor Imagery-Based Brain–Computer Interface and Neurofeedback on a Motorized Treadmill for Gait Recovery in Post-Stroke Patients	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Centro de Reabilitação Física do Espírito Santo (CREFES)	<NULL>	<NULL>	<NULL>	Over 18 years of age; patients with gait dysfunction resulting from stroke; clinically stable; good understanding and ability to follow the researchers’ instructions; willing to participate in the study and sign the informed consent form	Clinical instability; inability to maintain orthostasis; use of a pacemaker; uncontrolled epilepsy; skin disease at the stimulation site; lower limb orthopedic condition that limits gait; severe osteoporosis; score of grade 4 on the Ashworth Scale (fixed muscle/joint contracture) in the lower limb; lower limb amputation; active vascular thrombosis in the lower limb; severe heart failure; inability to adapt to the motor imagery–brain–computer interface; decompressive craniectomy; severe cognitive impairment; severe visual impairment; severe hearing impairment; severe sensory impairment of the lower limbs; decompensated psychiatric disorder; severe dizziness; severe lower limb ataxia	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-28nhd4q	Effects of non-invasive Neuromodulation in the treatment of pain of people with advanced Cancer - a randomized controlled clinical trial focusing on an occupation of daily living	Not yet recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8648	Effects of non-invasive Neuromodulation on pain management in people with advanced Cancer - randomized controlled clinical study focused on a daily life occupation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	"Inclusion criteria: have a diagnosis of head and neck cancer (of the oral cavity, larynx
or pharynx), age between 18 and 75 years and a pain score of at least 4 points on a numerical pain scale (ranging from 0 to 10 points)"	Exclusion criteria: pregnancy and intracranial tumor and or metastasis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-10wr3pqb	Rapid maxillary expansion: comparison between the invisalign palatal expander system and the hyrax appliance	Not yet recruiting	Intervention	2025-12-12	<NULL>	<NULL>	8651	Rapid maxillary expansion: comparison between the invisalign palatal expander and the hyrax appliance	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Age between 6 and 12 years; both sexes; mixed dentition stage; Class I or Class II molar relationship, or straight/mesial step in the primary dentition; cervical vertebral stage 1 or 2 (CVS methods 1–2); unilateral or bilateral posterior crossbite, involving primary or permanent teeth; patients diagnosed with transverse maxillary deficiency, characterized by a skeletal transverse discrepancy measured from the estimated center of resistance of the first molars ≤ –3 mm	Previous orthodontic treatment; patients with skeletal Class III; dental agenesis or presence of supernumerary teeth; craniofacial abnormalities; maxillary tooth impaction; presence of palatal torus; history of dental trauma, including avulsion and alveolar/maxillary fracture; refusal to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-87qssmm	Research investigates the relationship between chronic rhinitis and cognitive impairment in the elderly	Not yet recruiting	Observational	2025-12-15	<NULL>	<NULL>	8654	Investigation of the Impact of Chronic Rhinitis on Cognitive Decline in Older Adults	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Escola Paulista de Medicina	<NULL>	<NULL>	<NULL>	Men and women aged 60 to 70 years with and without a previous diagnosis of chronic rhinitis; Literate; Absence of neurological diseases; No other serious psychiatric disorders, such as schizophrenia and bipolar disorder; No diagnosis of substance use disorder	Refusal to participate in or perform any of the proposed activities; Omission of answers in tests essential for the analysis; Lack of progress or withdrawal during the evaluation process; Occurrence of incidents that prevent continued participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-6gx95tt	Effects of Therapeutic Taping on the lips of children with Trisomy 21	Not yet recruiting	Intervention	2025-12-16	<NULL>	<NULL>	8657	Therapeutic Taping effects on lip seal in children with Trisomy 21: comparison between Inelastic, Elastic, and Hyperelastic Tapes  a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Present Trisomy 21; be at least 2 years and at most 6 years old; not have complete lip sealing in the habitual position;  not be undergoing speech therapy for orofacial motor function.	Presence of other associated syndromes; craniofacial malformations; allergic reactions to the use of the bandage; skin lesions in the area where the bandage is applied.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-3yxrgtz	Use of Bone Marrow to reduce pain and improve mobility in Hip Osteoarthritis	Not yet recruiting	Intervention	2025-12-17	<NULL>	<NULL>	8660	Clinical efficacy of Intra-articular Injection of Bone Marrow Aspirate (BMA) and Bone Marrow Concentrate (BMAC) in the treatment of Hip Osteoarthritis: a triple-blind, randomized, controlled clinical trial	<NULL>	2, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Fundação Arnaldo Vieira de Carvalho	<NULL>	<NULL>	<NULL>	Volunteers; both genders; age of 18 years or older; with a confirmed diagnosis of hip osteoarthritis Tönnis grades 1 or 2; pain score greater than or equal to 4 on the visual analog scale; duration of visual analog scale pain for a minimum of 3 months; failure of previous conservative treatment	History of previous surgeries on the affected hip; previous episodes of joint infection; immunocompromiseds diagnosed with active autoimmune diseases; coagulation disorders diagnosis; predominant presence of neuropathic pain with a score greater than or equal to 4 on the Douleur Neuropathique 4 (DN4) questionnaire	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-5dnpdgn	Pelvic Muscle Training in Women with Urinary Incontinence During Running	Not yet recruiting	Intervention	2025-12-17	<NULL>	<NULL>	8661	Training of Conventional or Coordinated Pelvic Floor Muscles in Female Runners with Stress Urinary Incontinence: A Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-15	Faculdade de Educação Física e Fisioterapia	<NULL>	<NULL>	<NULL>	Female volunteers; runners; clinical presentation of urinary incontinence during running; age over 18 years.	Volunteer pregnant women; active urinary tract infection; diagnosis of neuromuscular diseases that compromise bladder function; history of pelvic or perineal surgeries to correct pelvic floor dysfunctions; pelvic prolapse; women who have previously undergone physiotherapy focused on treating dysfunctions of these muscles	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2y2jnn8	The effects of Laser application on acupuncture points on pain and heart rate variability in women with Fibromyalgia	Not yet recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8662	Effects of Laser application on HEGU (LI4) and TAICHONG (LR3) acupoints on pain and heart rate variability in women with Fibromyalgia: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Women aged 30 to 70 years; belonging to AGFESC; residing in municipalities within the AMREC, AMESC, and AMUREL regions; who have a prior medical diagnosis of fibromyalgia; chronic pain with a score equal to or greater than four on the Visual Analogue Scale (VAS); are available to participate in all stages of the study, including intervention sessions and assessments; and express their agreement to participate by signing the Informed Consent Form (ICF)	Women who present with active skin lesions at the laser application sites, such as open wounds or ulcerations; clinical conditions that contraindicate the use of phototherapy, such as active malignant neoplasms; inflammatory dermatological diseases at the application sites, such as psoriasis or dermatitis; decompensated or inadequately treated psychiatric disorders; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-38vmd97	Treatment of Bleeding in users of Contraceptive Implants (Implanon) with Ulipristal Acetate	Not yet recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8664	Randomized, experimental study of the use of oral Ulipristal Acetate as a treatment for Abnormal Uterine Bleeding in women using the Etonogestrel Contraceptive Implant (Implanon)	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	<NULL>	<NULL>	<NULL>	Women aged 18-45; etonogestrel implant users who experience prolonged or recurrent abnormal bleeding (bleeding lasting more than 14 days or episodes with intervals of less than 24 days)	Pregnant women; women who have given birth within the last six months, breastfeeding women; women with abnormal uterine bleeding of unknown cause prior to placement of the ENG implant; women with known pre-existing liver disease, women with blood dyscrasias; users of anticoagulants; users of medication that contraindicates the use of Ulipristal Acetate (vinblastine, digoxin, quinidine, dabigatran etexilate, phenytoin, barbiturates, loperamide, oxycarbamazepine, carbamazepine, rifampicin, griseofulvin, topiramate)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-107kny5q	Training of the non-operated leg and its effects on knee recovery after anterior cruciate ligament surgery	Not yet recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8666	Effects of Contralateral Strength Training After Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 18 and 40 years; patients with anterior cruciate ligament reconstruction surgery scheduled during the data collection period	Failure to attend the preoperative assessment session; initiation of the rehabilitation program more than three days after surgery; presence of injuries associated with anterior cruciate ligament rupture that prevent partial weight bearing during the first postoperative week due to medical indication or participant inability or unwillingness	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2vqkk95	Promoting emotional weel-being among workers - Apice Project	Not yet recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8671	Effectiveness of an intervention to promote psychological well-being and reduce symptoms associated with common mental disorders in workers - Apice Project	<NULL>	n/a, single-arm-study, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Fundação Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Workers; both sexes; 18 years of age or older, or emancipated; currently employed; agrees to participate in the study	Workers on leave; workers who do not complete the filling out of the forms	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-357dht4	Actions to Improve Well-Being and Reduce Emotional Problems at Work	Not yet recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8673	Effectiveness of Interventions to Promote Psychological Well-Being and Reduce Common Mental Disorders among Workers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Fundação Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Workers of both sexes; aged 18 years or older or emancipated; active employment link in one of the selected industrial sector companies distributed across the Regional Departments of the Social Service of Industry; signature of the Informed Consent Form	Absence from work activities due to vacation or leave of any kind during the data collection period; non-completion of the data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-3kprqcz	Use of personal care formulations for the control of gingivitis and dental hypersensitivity	Not yet recruiting	Intervention	2025-12-22	<NULL>	<NULL>	8675	Gingival status and dentin hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia	<NULL>	<NULL>	<NULL>	Men and women, aged 18 to 75 years; At least 20 natural permanent teeth; Good general systemic health as determined by the study investigators; Presenting two teeth (incisors, canines, premolars or 1st molar) with a qualified response to the stimulus of a jet of cold air applied per second to the cervical surface, with a score of 2 or 3, according to the scoring defined on the Schiff Cold Air Sensitivity Scale and a gingival index greater than 1, according to the Löe and Silness index); Presenting gingival inflammation.	Individuals who smoke; Pregnant women; Individuals using systemic medications; Development of a medical condition and/or use of medication that may affect the study results; Periodontitis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10wjzrt7	Effect of intervention with exercises and pain neuroscience education on physical, cognitive, and emotional function and gait parameters of elderly people with and without knee osteoarthritis: a randomized clinical trial	Not yet recruiting	Intervention	2025-12-22	<NULL>	<NULL>	8676	Effect of intervention with multicomponent exercises and pain neuroscience education on physical, cognitive, psychoemotional function and gait parameters of elderly individuals with and without Knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-31	Obras Socias e Educacionais de Luz	<NULL>	<NULL>	<NULL>	Age between 60 and 80 years; female and masculine gender; diagnosis of Medial Femorotibial Osteoarthritis confirmed by X-ray examination; grade 2 or 3 Knee Osteoarthritis according to the Kellgren and Lawrence criteria	Diagnosis of Osteoarthritis in the Hip and/or Ankle; grade 4 Osteoarthritis in one or both knees; body mass index less than 35 kg/m²; presence of Vestibulocochlear Diseases; uncontrolled Cardiac or Respiratory Arrhythmias; Convulsive Syndrome; Musculoskeletal Disorders with functional limitation, such as Diabetic Neuropathies and Cutaneous Ulcers of any etiology; use of Prostheses or Orthoses in the lower limbs; Fractures in the last six months; presence of Dementia; inability to Walk independently; being under Physical Therapy treatment concurrently with the intervention period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-5bdqznf	Effects of Positive Expiratory Pressure on Airways in Infants with Pneumonia	Not yet recruiting	Intervention	2025-12-23	<NULL>	<NULL>	8678	Effects of Airway Positive Expiratory Pressure (PEP) on Respiratory Distress and Secretion Volume in Hospitalized Infants with Pneumonia: protocol for a randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Ciências da Saúde do Trairi - Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Infants aged between 29 days and 2 years; hospitalized in pediatric wards with a clinical diagnosis of pneumonia; parents or legal guardians accompanying the infants during hospitalization aged 18 years or older	Infants with chronic respiratory conditions; congenital heart disease; malformations of the thoracic cage and or upper airways; associated acute respiratory diseases such as acute viral bronchiolitis, tuberculosis or pertussis; neurological disorders; hemodynamic instability; need for invasive or noninvasive mechanical ventilation at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-48z43w9	Effects of non-invasive brain stimulation on brain and muscle activity in people with amyotrophic lateral sclerosis	Not yet recruiting	Intervention	2025-12-23	<NULL>	<NULL>	8679	Effects of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on different cortical areas on neural connectivity, cortical excitability, and muscle activity in individuals with amyotrophic lateral sclerosis: a proof-of-concept study.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Departamento de Fisioterapia	<NULL>	<NULL>	<NULL>	Individuals diagnosed with amyotrophic lateral sclerosis according to the Gold Coast criteria; age between 18 and 80 years; both sexes; adequate cognitive performance defined by a score ≥17 on the ALS Cognitive Behavioral Screen; ability to perform functional movements of the upper limbs; neurotypical individuals without a diagnosis of neurological disease; age between 18 and 80 years; both sexes; adequate cognitive performance defined by a score ≥17 on the ALS Cognitive Behavioral Screen; ability to perform functional movements of the upper limbs	Presence of neuropsychiatric disorders; history of seizures or epilepsy; history of traumatic brain injury; presence of metallic clips, pacemakers, or deep brain stimulation implants; history of neurosurgery; alcohol abuse or drug dependence	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10t8dj3b	Comparison of different types of implants in various clinical situations and loading protocols - Ongoing clinical study	Not yet recruiting	Intervention	2025-12-24	<NULL>	<NULL>	8681	Comparative evaluation of different implant designs in various clinical situations and loading protocols. a prospective clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Male and female patients; Patients aged between 18 and 75 years; Patients in good general health (physical and mental) at the time of surgery; Patients who provide free and informed consent	Patients who smoke; Patients with a known history of current alcohol, drug, or medication abuse; Patients with systemic non-controlled diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-76b23nf	Chronic insomnia: integrative approaches with auriculotherapy and laser acupuncture to improve sleep	Not yet recruiting	Intervention	2025-12-26	<NULL>	<NULL>	8683	Integrative and complementary health practices (PICS) in the management of chronic primary insomnia: auriculotherapy and systemic laser acupuncture	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal do Maranhão	<NULL>	<NULL>	<NULL>	Age between 18 and 70 years; male and female gender; with spontaneous complaint of insomnia; agree to participate in the research by signing the Informed Consent Form; agree to provide a urine sample for biochemical and toxicological analyses; meet the clinical criteria for chronic insomnia as assessed in the anamnesis; receive diagnostic confirmation of chronic insomnia from a medical professional who is part of the research team; be available to attend all treatment sessions uninterruptedly; obtain a score equal to or greater than 5 points on the questionnaire Pittsburgh Sleep Quality Index, Brazilian version	Pregnant women; smokers; history of chronic alcohol and drug use	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-5wk24cp	Impact on wound healing after third molar extraction using a mouthwash containing green tea and hyaluronic acid or 0.12% chlorhexidine	Not yet recruiting	Intervention	2026-01-05	<NULL>	<NULL>	8691	Impact on wound healing after third molar extraction using a mouthwash containing green tea and hyaluronic acid or 0.12% chlorhexidine. Randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Patients must be over 18 years of age; Patients must have good oral hygiene (plaque index &lt; 20%); Patients must have all four third molars and be indicated for extraction of all third molars	Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except diabetics); Uncontrolled diabetics (glycated hemoglobin above 8%); Pregnant or breastfeeding women; Heavy smokers (more than 10 cigarettes daily); Presence of periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-4244wxy	Effects of therapeutic treatment using tactile stimulation and joint movement, and skin-to-skin contact on the motor behavior of premature newborns: a non-inferiority randomized controlled clinical trial protocol.	Not yet recruiting	Intervention	2026-01-05	<NULL>	<NULL>	8694	Effect of Tactile-Kinesthetic Stimulation and the Kangaroo Method on the motor behavior of premature newborns: a non-inferiority randomized controlled clinical trial protocol	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-15	Empresa Brasileira de Serviços Hospitalares - EBSERH	<NULL>	<NULL>	<NULL>	Preterm newborns admitted to the Neonatal Intensive Care Unit of the Hospital da Mulher Mãe Luzia will be included in the study provided they are born with a gestational age between 28 and 36 weeks; with a corrected gestational age of 32 weeks or more; with an Apgar score greater than 6 at 1 and 5 minutes; of both sexes; older than 72 hours; with a body weight above 1.100g; presenting hemodynamic and clinical stability; receiving full enteral nutrition; via nasogastric or orogastric tube; or breastfeeding; in an incubator or crib; breathing room air or receiving support such as non invasive ventilation and oxygen supplementation	Preterm newborns will be excluded from the study if they present with congenital malformations; genetic syndromes; worsening of the underlying disease; hemodynamic and clinical instability; hypothermia; use of sedatives; thrombocytopenia with a value lower than 50.000; active hemorrhage; peri intraventricular hemorrhage; are on invasive mechanical ventilation; have a positive C Reactive Protein test; are in contact isolation or have experienced a cardiorespiratory arrest in the last 24 hours	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-4xbyr8g	Effect of Antioxidant gel on aesthetic Restorations performed after in-office Tooth Bleaching	Not yet recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8697	Effect of Caesalpinia pyramidalis gel on aesthetic Restorations performed after in-office Tooth Bleaching: Eandomized clinical trial	<NULL>	3, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Programa de Pós-Graduação em Odontologia	<NULL>	<NULL>	<NULL>	Participants must be over 18 years of age; have good oral hygiene; not have periodontal disease; have at least two Class III restorations with vestibular access in the upper anterior teeth; not have undergone whitening treatment in the last 3 years; and have a right upper canine with a color of A2 or darker	Pregnant and breastfeeding women; volunteers with a history of allergies to dental products and who use orthodontic appliances. The selected teeth must not present caries lesions, pulpitis, endodontic treatment, dentin hypersensitivity, or absence of adjacent and antagonist teeth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-7zygtt6	Comparison of two strategies to adjust blood pressure medication in patients with severe infection and shock	Not yet recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8698	Strategy of norepinephrine titration guided by peripheral perfusion versus conventional strategy guided by arterial pressure in patients with septic shock	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Fundação Universidade Caxias do Sul Hospital Geral	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; suspected or confirmed septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock; requirement for vasopressor therapy to maintain a mean arterial pressure of 65 millimeters of mercury or higher after adequate fluid resuscitation; serum lactate level of 2 millimoles per liter or higher; initiation of norepinephrine within the previous 12 hours; admission to the intensive care unit of Hospital Geral de Caxias do Sul; written informed consent provided by the participant or legal representative	Limitation of life sustaining treatment or do not resuscitate order; chronic dialysis or indication for renal replacement therapy within the next 8 hours; age younger than 18 years; hypotension not related to sepsis; traumatic brain injury; recent stroke; scleroderma; sickle cell disease; significant arrhythmias; pregnancy; refusal to participate in the study; severe peripheral vascular disease; hemorrhagic shock; cardiogenic shock; obstructive shock	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-5zd29xp	Virtual reality games for studying the movements of neurodivergent people	Not yet recruiting	Observational	2026-01-06	<NULL>	<NULL>	8700	The interaction between neurodivergent individuals and virtual reality games as a means of identifying movement patterns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Carlos Bandeira de Mello Monteiro	<NULL>	<NULL>	<NULL>	Children and neurodivergent adults with a prior diagnosis of at least one of the following conditions: Autism Spectrum Disorder; cerebral palsy; Down syndrome; intellectual developmental disorder; among others. Applicants of both sexes and without age restrictions; must have sufficient motor and cognitive skills to interact with virtual reality games; have stable medical conditions; and possess a level of verbal or non-verbal communication that allows for comprehension of the game&apos;s task	Participants unable to understand and execute the specific instructions and commands of the intervention; failure to adapt to the proposed intervention protocol; visual impairments; severe hearing impairments that prevent interaction with virtual reality games	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-9gqtzng	Assessment of vascular permeability with Point-of-Care ultrasound: an experimental study	Not yet recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8710	Assessment of peripheral venous catheter patency using Point-of-Care Ultrasound (POCUS)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; of both sexes; using peripheral intravenous devices.	Patients with peripheral intravenous devices for surgical reasons, as it is not possible to assess adequate device patency. Patients with vasculitis, as they may present changes characteristic of the pathology, preventing adequate visualization of the venous network.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-7txk58d	Study for the evaluation of grafting in the surgical treatment of Peyronie&apos;s disease.	Not yet recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8711	Randomized comparative study to evaluate the clinical aspects of the Vivendi UR® aldehyde-free graft in the surgical treatment of Peyronie&apos;s disease.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Fundação do ABC	<NULL>	<NULL>	<NULL>	Patients presenting with Peyronie&apos;s Disease in the chronic phase; with curvature greater than 60 degrees preferably uniplanar (patients with biplanar curvature will be accepted if secondary curvature is less than 20 degrees); without penile deformities with significant volume loss; patients must report adequate erectile function (erectile function questionnaire score greater than 22, reflecting adequate erection for vaginal penetration if penile curvature were absent); patients will undergo Penile Doppler Ultrasound with pharmacologically-induced erection to confirm normal penile hemodynamic status; heterosexual patient with sexual partner (patients with exclusive vaginal penetration); ability to complete questionnaires; able to read; be over 18 years old	Prior treatment for Peyronie&apos;s disease within the last three months; clinical contraindication for corrective surgery;  lack of rigidity for penetration; patients undergoing treatment for malignant diseases; patients who do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-6x33wsm	Functional Training for older people: functional aptitude, body composition, cognition and immunological parameters	Not yet recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8713	Effects of functional training on functional status, body composition, cognitive function and immunosenescence of older people	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Universidade Federal de Sergipe - Campus Lagarto	<NULL>	<NULL>	<NULL>	Participants must be women aged 60 to 80; be physically independent; have no cardiovascular or musculoskeletal comorbidities, nor uncontrolled conditions that prevent physical exercise; not be undergoing hormone replacement therapy; and not have engaged in regular physical activity/exercise (two or more times per week) in the six months prior to the start of the study	After the interventions begin, participants who participate in additional regular physical exercise programs, consume ergogenic dietary supplements, miss four consecutive sessions, or do not achieve an attendance rate of 75% will be excluded from the protocol analysis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-22csg9k	Preventing the transmission of HTLV-1 from mother to child with antiretroviral therapy	Not yet recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8718	Preventing vertical transmission of HTLV-1 with Integrase inhibitors	<NULL>	2-3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Centro de Pesquisas Gonçalo Moniz - CPqGM/ FIOCRUZ/ BA	<NULL>	<NULL>	<NULL>	Pregnant women living with Human T-lymphotropic Virus type 1 (HTLV-1), with diagnosis confirmed by Western blot, line immunoassay, or real-time polymerase chain reaction (qPCR); who agree to and consent to the participation of their newborns; and who have availability to attend the project visits.	Gestational age of 37 weeks or more; coinfection with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV); presence of conditions that may compromise, in the investigator’s opinion, the safety of Dolutegravir (DTG) use and/or adherence to the protocol; participation in another clinical trial involving the use of antiretroviral agents or an experimental medication against Human T-lymphotropic Virus type 1 (HTLV-1); use of concomitant medication, including one or more agents capable of inducing the enzyme uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) and reducing Dolutegravir (DTG) concentrations, such as rifampicin, phenytoin, phenobarbital, or carbamazepine; use of concomitant medication that are substrates of the organic cation transporter 2 (OCT2), including but not limited to dofetilide, pilsicainide, or fampridine (also known as dalfampridine); individuals with known hypersensitivity to Dolutegravir (DTG) or any of its excipients. Exclusion criteria for the use of Dolutegravir (DTG) in newborns: gestational age less than 37 weeks at birth; birth weight less than 2 kilograms; known blood incompatibilities that may result in hemolytic disease of the newborn; hemoglobin value less than 13.0 g/dL; platelet count less than 50,000 cells/mm³; decreased total leukocyte count (Grade 3); creatinine value greater than 1.3 times the upper limit of normal (ULN) for gestational age and postnatal age (Grade 2); aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than 2.5 times the upper limit of normal (Grade 2); any other current Grade 3 event described in the toxicity table of the Division of Acquired Immunodeficiency Syndrome (DAIDS); severe congenital abnormalities or severely ill neonates, at the discretion of the examining physician	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-33j54zk	Effects of Periodontal Treatment on radiotherpay induced Oral Mucositis	Not yet recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8720	Impacts of Basic Periodontal Treatment on  Radiation-induced Oral Mucositis.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Head and neck cancer patients aged 18 years or older; patients diagnosed with periodontal health or periodontitis stages I, II, III, or IV; Patients who will undergo head and neck radiotherapy as part of the oncologic treatment plan for head and neck cancer	Patients under 18 years old; Patients who have received dental treatment within the six months preceding recruitment; Pacients who have previously undergone radiotherapy or chemotherapy; Patients who are currently using bone resorption inhibitors or immunosuppressive drugs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-107c6rvs	Evaluation of the effect of two anesthetic techniques on the quality of hearing examination in children.	Not yet recruiting	Observational	2026-01-08	<NULL>	<NULL>	8722	Comparison between intravenous and inhalation anesthesia for performing the BERA test in pediatric patients.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Hospital de Clínicas da Universidade Federal do Paraná	<NULL>	<NULL>	<NULL>	Pediatric patients under 18 years of age; medical indication for auditory brainstem response testing under sedation/anesthesia;  consent of guardians	Severe neurological diseases; known allergy to anesthetic agents. clinical instability; previous use of medications that may alter the test	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-6q3kyyk	Use of Adenosine to improve heart protection during cardiopulmonary bypass surgery: a clinical study	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8723	Effect of Adenosine Addition on myocardial protection during extracorporeal circulation: a double-blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital Nossa Senhora da Conceição	<NULL>	<NULL>	<NULL>	All patients undergoing elective surgery for simple valve replacement or myocardial revascularization with extracorporeal circulation at Hospital Nossa Senhora da Conceição, Porto Alegre, aged 18 years or older, in accordance with the Informed Consent Form.	The following cases will be excluded from the study: previous cardiac surgery; chronic renal failure (serum creatinine greater than 2.0 mg/dl); severe psychiatric illness; urgent or emergency situations; multiple surgeries.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-5xs4wzx	Effects of two different nutritional strategies in adults with prolonged symptoms of Covid-19	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8725	Effects of two different nutritional strategies in adults with prolonged symptoms of Covid - 19	<NULL>	n/a, n/a, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-26	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Adults who meet the established inclusion criteria will be recruited, including age between 40 and 59 years; presence of overweight or obesity according to the cutoff points established by the World Health Organization in 2005; signed informed consent form; availability to participate in multiprofessional interventions twice a week in the morning period for 12 weeks; and attendance at the initial project assessments	As exclusion criteria participation in sports activities outside the project; failure to achieve at least 75 percent attendance in the offered interventions; absence for more than two consecutive sessions in the program; failure to follow the proposed recommendations such as adherence to the diet; presence of orthopedic cardiovascular conditions or cognitive impairments that prevent the practice of physical exercise; following another type of non recommended restrictive diet; use of psychotropic medications or appetite suppressants; and occurrence of any accident that makes participation in the practical interventions impossible	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-3gbsyc2	Effects of the Thoracoabdominal Rebalancing (TAR) Method in preterm infants	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8729	Effects of the Thoracoabdominal Rebalancing (TAR) Method in preterm newborns: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Ciências da Saúde do Trairi - Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Preterm newborns of both sexes; with gestational age of less than 37 weeks; chronological age greater than 96 hours of life; receiving non-invasive ventilation (NIV), including Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (Bilevel); and with Silverman-Andersen Score (SAS) greater than 0	Newborns presenting hemodynamic instability (persistent alterations in heart rate or blood pressure above or below expected values or predefined alarm limits, and difficult-to-control arrhythmias); use of invasive mechanical ventilation (IMV); a clinical diagnosis of pneumothorax, pleural effusion, atelectasis, anemia, or structural and/or functional abnormalities of the chest wall, diaphragm, or upper airways; cardiovascular malformations; and diagnosed genetic syndromes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-8w2wr4y	Effect of Music on Pain Relief During Arterial Introducer Removal via Femoral Route	Not yet recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8734	Effect of music on pain relief during femoral arterial introducer withdrawal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Departamento de Enfermagem da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Patients admitted to the hemodynamics unit of the Onofre Lopes University Hospital for cardiac catheterization or arteriography of the lower limbs; need for removal of an arterial introducer via the femoral approach; elective procedures; individuals aged 18 years or older	Dislike of music; patients who have undergone cardiac catheterization or arteriography of the lower limbs; presence of chronic pain; previous analgesia; individuals with any neurological and/or cognitive problem that compromises the understanding and use of the scale and data collection instruments; individuals with hearing impairment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-7t7gy3x	Effect of laser therapy in the treatment of inflammation around implants with or without the use of soft tissue grafts	Not yet recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8737	The effect of photobiomodulation in the treatment of patients with peri-implantitis, with or without the use of soft tissue grafts	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with at least one implant diagnosed with peri-implantitis; The implant must present: radiographic bone loss &gt; 2mm; probing depth &gt; 5mm; bleeding and/or suppuration on probing; prosthesis with at least 6 months of function; absence of implant mobility; age ≥18 years	Patients with previous peri-implant treatment at the surgical site; ASA III patients (except diabetics); Heavy smokers (&gt;20 cigarettes/day); Uncontrolled diabetic patients (HbA1c &gt; 7% or fasting glucose &gt; 180 mg/dL); Use of antibiotics in the last 30 days; Use of medications that alter the inflammatory response or bone metabolism; Pregnant and breastfeeding women; Patients with hemoglobinopathies; Patients with other systemic alterations that may compromise healing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-3kwhcht	Evaluation of the Efficiency of a Bedside Mobility Scale in a Hospital Setting	Not yet recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8744	Evaluation of the effectiveness of implementing a bedside mobility scale in a hospital unit	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade de Passo Fundo	<NULL>	<NULL>	<NULL>	Hospitalized patients who were able to ambulate without mobility restrictions before admission	Patients with restricted mobility due to environmental barriers such as isolation rooms or the use of devices that impede mobility; hospitalized clinical patients awaiting elective surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-5zjkx4y	Strategies to relieve pain during childhood vaccination: a study on non-pharmacological methods for children aged 1 to 4.	Not yet recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8745	Effect of Buzzy®, Pikluc® and breastfeeding versus usual care on pain during vaccination in children aged 12 to 48 months: pilot randomized clinical trial protocol.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Estadual de Feira de Santana	<NULL>	<NULL>	<NULL>	Age 12 to 48 months and 29 days; both sexes; child awake; child accompanied by parents or legal guardian over 18 years old capable of consenting; not having received analgesics or sedatives in the 12 hours before entry into the research; indication for meningitis vaccine via intramuscular route at the time of inclusion; breastfeeding children and mother available to breastfeed before and during the procedure	Fever equal to or greater than 37.5°C on the day; cold hypersensitivity; Raynaud&apos;s disease; sickle cell anemia; vascular diseases; having undergone needle interventions on the same day; skin lesions or nodules at the application site; cognitive deficit or any psychiatric condition such as autism, depression or anxiety; severe neurological conditions that alter behavioral assessment such as epilepsy or cerebral palsy; history of severe adverse reactions to vaccines; withdrawal by the guardian	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-7g5dxr5	The effectiveness of continuous cuff pressure monitoring versus intracuff lidocaine or seal pressure method in preventing postoperative odynophagia in pelvic surgery a randomized clinical study	Not yet recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8750	The effectiveness of continuous cuff pressure monitoring versus intracuff Lidocaine or seal pressure method in preventing Postoperative odynophagia in pelvic surgery a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-19	Rede D&apos;Or São Luiz S.A.	<NULL>	<NULL>	<NULL>	Adult patients aged 18 years or older; classified as physical status I or II according to the American Society of Anesthesiologists; Mallampati classification grades I to III, with grade III accepted only in the absence of other predictors of a difficult airway; scheduled for elective laparoscopic pelvic surgery; indication for general anaesthesia combined with spinal anaesthesia; requirement for planned orotracheal intubation; surgical positioning in the supine position with a mild Trendelenburg tilt; both sexes	Refusal to participate in the study; presence of sore throat in the preoperative period; active smoking; prior history of oral or nasal surgery; active upper respiratory tract infection; pregnancy; chronic obstructive pulmonary disease; known allergy to any of the medications used in the study; increased risk of aspiration or gastro-oesophageal reflux; requirement for nasogastric tube insertion intraoperatively; presence of clinically relevant cardiopulmonary, neuromuscular, renal, or hepatic disease; use of succinylcholine; requirement for rapid sequence induction; anticipated difficult airway defined as Mallampati classification grade IV; need for more than one orotracheal intubation attempt; patients with a prior history of laryngeal disease; previous tracheostomy; chronic users of opioids or illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-2w6dxtx	How periodontal treatment can influence good cholesterol (HDL) in patients with type 2 diabetes	Not yet recruiting	Intervention	2026-01-14	<NULL>	<NULL>	8757	Effect of Periodontal Treatment on HDL in patients with type 2 Diabetes Mellitus and Periodontal Disease	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Instituto de Ciência e Tecnologia de São José dos Campos	<NULL>	<NULL>	<NULL>	Type 2 diabetics with periodontitis: diagnosis of periodontitis stages III or IV, grades B or C; age over 35 years; both sexes; diagnosis of type 2 diabetes mellitus – DM2; glycated hemoglobin levels between 7% and 11%; clinical attachment loss greater than 3 mm in two non-adjacent teeth and greater than or equal to 5 mm in at least 30% of the teeth; presence of a minimum of 15 teeth; formal consent through the Free and Informed Consent Form – TCLE. Type 2 diabetics without periodontitis: biofilm-induced gingivitis, associated with local or systemic factors; age over 35 years; both sexes; diagnosis of DM2 for more than 5 years; glycated hemoglobin levels between 7% and 11%; presence of at least 15 teeth; signature of the TCLE. Normoglycemic patients with periodontitis: diagnosis of periodontitis stages III or IV, grades B or C; age over 35 years; both sexes; clinical attachment loss greater than 3 mm in two non-adjacent teeth and greater than or equal to 5 mm in at least 30% of the teeth; presence of a minimum of 15 teeth; formal consent through the TCLE	Cardiovascular diseases, cancer, autoimmune diseases, gastrointestinal diseases, skin diseases, arthritis, lupus; pregnant or lactating women; smokers; patients who have undergone periodontal treatment in the last 12 months; recent change (within the last 3 months) in glycemic index or medication; other systemic inflammatory diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-2skzsv2	Periodontal health and response to non-surgical periodontal therapy in transgender individuals undergoing hormone therapy	Not yet recruiting	Observational	2026-01-15	<NULL>	<NULL>	8759	Periodontal status and response to non-surgical periodontal therapy in transgender individuals undergoing hormone therapy: clinical, microbiological, and immunological assessment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-19	Faculdade de Odontologia - Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Participants eligible for inclusion will be individuals aged 18 to 60 years who identify as transgender men or transgender women. The case group will consist of participants undergoing hormone therapy, whereas the control group will include transgender individuals not receiving hormonal treatment. Groups will be age-matched within a ±3-year range. All participants must present a diagnosis of periodontitis in stages I, II, or III according to the criteria of Caton et al. (2018) and the 2021 American Academy of Periodontology classification, defined by clinical attachment loss affecting two or more non-adjacent interproximal sites or by clinical attachment loss of at least 3 mm on the buccal or lingual/palatal surfaces of at least two teeth. Only cases in which attachment loss is not attributable exclusively to traumatic gingival recession, cervical caries, distal attachment loss associated with third molar eruption, draining endodontic-periodontal lesions, or vertical root fractures will be considered eligible.	Participants will be excluded if they present loss of five or more teeth due to periodontitis, have used antibiotics within the previous six months, or have undergone non-surgical periodontal therapy during the same period. Individuals with systemic conditions that may influence periodontal disease progression or treatment response—such as diabetes or immunological disorders—will also be excluded, as well as those requiring antibiotic prophylaxis for routine dental procedures, those under prolonged use of anti-inflammatory medications, and pregnant individuals. Participants younger than 18 years of age or those who do not provide written informed consent will not be included.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-6qvzppn	How the Consumption of Vitamin D–fortified Milk can influence the Physical Health and Emotional Well-being of young women	Not yet recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8761	Effects of Consuming Vitamin D-enriched Semi-skimmed Milk on Nutritional and Inflammatory Biomarkers and Psychological Symptoms in young women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Faculdade de Saúde Pública  da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Cisgender women aged 18 to 35; with a body mass index (BMI) between 18.5 and 29.9 kg/m2 (normal weight and overweight); available to participate in all phases of the study; with regular internet access and a mobile device to communicate with the research team during the study period; who do not have an active diagnosis of psychiatric disorders such as anxiety, depression, and stress, and who consume milk and dairy products daily.	Lactating women; pregnant women; or women in the menopausal period (perimenopause and post-menopause); smokers; those intolerant or allergic to milk and dairy products; those following vegan and/or strict vegetarian diets; those using controlled medications (antidepressants and/or anxiolytics) and supplementing with vitamin D, calcium, or any nutrient with a potential effect on the study outcome up to 3 months prior to the study; those with decompensated metabolic disorders (type II diabetes mellitus, hypertension, and metabolic syndrome); concomitant participation in another clinical trial, and those with an active diagnosis of psychiatric disorders such as anxiety, depression, and stress.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-2qpj7vq	Surgery and Survival in People Aged 80 Years and Older in Private Hospitals in Brazil	Not yet recruiting	Observational	2026-01-15	<NULL>	<NULL>	8762	Surgical Mortality in Very Elderly Patients: A Multicenter Retrospective Cohort Study in a Network of Private Hospitals in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-13	Rede D&apos;Or São Luiz S.A.	<NULL>	<NULL>	<NULL>	patients aged eighty years or older, both gender, at the time of the surgical procedure; patients undergoing elective urgent or emergency surgical procedures requiring hospital admission; patients treated at private hospitals of the Rede D Or network located in the state of São Paulo	age younger than eighty years at the time of surgery; same day hospital discharge after the surgical procedure; patients undergoing exclusively diagnostic procedures such as upper gastrointestinal endoscopy, colonoscopy, or coronary catheterization; electronic medical records with incomplete, inconsistent, or unavailable data	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-7v2k495	Cashew nut plant-based beverage and its effects on the health of climacteric women	Not yet recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8763	Consumption of vegetable drink based on by-products of chestnut cashew (Anacardium occidentale L.) and health markers in women climaterium	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Departamento de Nutrição e Saúde da Universidade Fedral de Viçosa	<NULL>	<NULL>	<NULL>	Women; aged 40 to 60 years; Body Mass Index classification as overweight (greater than or equal to 25 kg/m²) and obese (30 kg/m²); elevated waist circumference (greater than or equal to 80 cm for women) and excess body fat (greater than 32% for women)	Women under 40 years of age; men; body mass index lower than 30 kg/m²; athletes; shift workers; individuals with physical and/or intellectual disabilities; individuals who have undergone bariatric surgery; have experienced weight instability (5% of their usual weight) over the past three months; individuals following vegan, vegetarian, or restrictive diets (for example, gluten-free or lactose-free diets); pregnant and lactating women; patients with type 1 diabetes mellitus; autoimmune or immunosuppressive diseases (human immunodeficiency virus infection, rheumatoid arthritis, lupus); hormonal disorders (hyperthyroidism or hypothyroidism, Cushing’s syndrome); digestive diseases or disorders (gastritis, peptic ulcer disease, esophagitis, dysphagia, or chewing difficulties); individuals with inflammatory bowel diseases (ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, irritable bowel syndrome); hepatic diseases (hepatic failure, hepatitis, cirrhosis), renal diseases (chronic kidney disease), pancreatitis, cardiovascular diseases (angina, acute myocardial infarction, congestive heart failure), eating disorders (anorexia nervosa, bulimia nervosa, binge eating disorder), or cancer; history of illicit drug use and/or alcohol consumption exceeding 14 units per week; use of hormone replacement therapy; use of products enriched with prebiotics or probiotics (at least three weeks prior to screening) and use of fiber supplements (psyllium, inulin) or intake of large amounts of fermented foods (greater than 400 g/day); aversion or allergy to nuts; infectious episode in the previous month; use of anti-inflammatory drugs, corticosteroids, antibiotics, or other medications that may affect appetite and energy metabolism; habitual nut consumption exceeding 30 g/day; alcohol consumption exceeding 21 units (168 g) per week; and use of vitamin, mineral, or omega-3 supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-10ps9fwx	Use of hyaluronic acid and green tea-based gel and mouthwash after dental implant placement	Not yet recruiting	Intervention	2026-01-16	<NULL>	<NULL>	8767	Evaluation of the peri-implant healing using a mouthwash and gel based on hyaluronic acid and green tea	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Ages between 18 and 70; patients who requiring dental implants to replace one or more teeth	Patients who are heavy smokers (More than 20 cigarettes per day); patients with uncontrolled diabetes (glycated hemoglobin above 8%); patients who are pregnant or breastfeeding; who do not agree to return for follow-u; and who have used corticosteroids;  chemotherapy;  and immunomodulators in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4vdkhwv	Brain and tibial nerve stimulation to improve urinary symptoms in Parkinson’s disease	Not yet recruiting	Intervention	2026-01-17	<NULL>	<NULL>	8769	Transcranial and tibial nerve electrical stimulation on overactive bladder symptoms in Parkinson’s disease – a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Medical diagnosis of Parkinson’s disease. both genders. age greater than or equal to 18 years. use of antiparkinsonian medication at stable doses for at least four weeks prior to study inclusion. not undergoing any other treatment for overactive bladder during the study period, including pelvic floor physical therapy. presenting at least two symptoms of overactive bladder according to the definition by Haylen et al. characterized by urinary urgency with or without urinary incontinence, urinary frequency greater than seven voids per day and nocturia greater than one void per night. presenting a minimum score of 22.5 points on the Montreal Cognitive Assessment, translated and adapted version. agreement to participate in the study and signing of the informed consent form	History of bladder outlet obstruction. history of pelvic radiotherapy. active bladder carcinoma. history of peripheral nerve injury. active lower urinary tract infection. uncontrolled diabetes mellitus. pregnancy or immediate postpartum period less than six months. urinary incontinence exclusively due to stress. presence of a cardiac pacemaker or implantable defibrillator. presence of metallic implants. botulinum toxin application to the bladder and or pelvic muscles within the past year. history of seizures. current use of anticoagulant medications. current use of anticholinergic medications. other central or peripheral neurological disorders that may interfere with neuromuscular transmission	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4wcdqxw	Safety and Efficacy of Zygomatic and Pterygoid Implants in Comparison	Not yet recruiting	Intervention	2026-01-20	<NULL>	<NULL>	8780	Safety and Efficacy of Zygomatic and Pterygoid Implants: A Non-Inferiority Study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Patients with an indication for full maxillary rehabilitation; Patients aged 18 years or older, of both sexes; Patients with sufficient bone availability for the placement of two zygomatic implants, two pterygoid implants, and two conventional anterior implants	Patients with uncontrolled systemic diseases; Smokers who consume more than 10 cigarettes per day; Patients using medications that may impair bone healing, such as bisphosphonates and corticosteroids	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-9cqvm3t	Effect of Laser Therapy on lower limb pain in people with Diabetes: a randomized clinical trial.	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8782	Effect of Photobiomodulation on neuropathic pain in people with Diabetes: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-06	Faculdade de Enfermagem - Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18-65 years; diagnosis of diabetic peripheral neuropathy; ability to walk independently without equipment or devices.	Amputation of any part of the foot; ankle-brachial index &lt; 0.9.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-3hkxkc7	Effect of Probiotics on the Health Parameters of Cardiac Individuals	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8784	Effect of Probiotic supplementation on inflammatory markers and cardiovascular risk, indicators of nutritional status, and clinical parameters in individuals undergoing Cardiac Surgery	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Faculdade de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Patients requiring revascularization; adults and elderly; of both sexes; undergoing surgical treatment for cardiovascular disease or following an acute coronary event. Eligibility will be confirmed through analysis of the participant&apos;s medical record and by questioning the participant	Individuals following unusual diets; those with food intolerances or allergies; and those using drugs or supplements that can directly alter the immune system, gut microbiota, and appetite, as these are confounding or effect-modifying factors in this type of intervention. Patients with morbid obesity; uncontrolled blood glucose or cholesterol levels. Probiotic intake for less than three months. Inability to comply with the study procedure. As a discontinuation criterion, participants who go for two consecutive days or more without consuming the supplement	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4z9mt9h	Photobiomodulation and Vestibular Rehabilitation in women	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8787	Photobiomodulation Combined with Vestibular Rehabilitation in women with Unilateral Peripheral Hypofunction: a randomized, blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Women; aged between thirty and forty years; bilateral hearing thresholds within normal limits according to pure tone and speech audiological assessment; speech language pathology diagnosis of unilateral peripheral vestibular hypofunction identified by the video head impulse test vHIT specifically characterized by alterations in vestibulo ocular gain at high head impulse frequencies; presence of intact middle ear and auditory pathways up to the brainstem confirmed by acoustic immittance measures and stapedial reflex testing; absence of a history of diseases related to neurological disorders and cognitive complaints that would prevent the performance of examinations or questionnaires	Presence of unilateral or bilateral hearing loss, regardless of type; presence of bilateral vestibulopathy; presence of central vestibulopathy; history of restricted ocular movement, including vergence disorders, strabismus, or high-degree refractive errors; alterations related to right ocular globe movement, right eyelid ptosis, as well as scars that impair detection of the right pupil; limitations in cervical mobility; presence of metabolic disorders or uncontrolled blood pressure; significant hormonal alterations, such as thyroid disorders, use of hormone replacement therapy, or use of contraceptives that may interfere with vestibular function or emotional state; clinical diagnosis of depression based on medical evaluation or prior report with use of antidepressant medication; functional or structural alterations of the middle ear identified through acoustic immittance assessment or otologic clinical examination	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-3vzdfyz	Effectiveness of the mbrp ser online protocol in synchronous and asynchronous versions among university students	Not yet recruiting	Intervention	2026-01-23	<NULL>	<NULL>	8792	Effectiveness of the online synchronous and asynchronous versions of the MBRP Ser protocol among university students: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Be enrolled in an undergraduate or graduate program or be employed at one of the partner universities;  have agreed to participate in the study	Have a diagnosis of bipolar disorder; schizophrenia; another severe mental disorder; or a moderate to high risk of suicide; present acute symptoms of depression or anxiety without professional follow-up; have cognitive or sensory or motor impairments that may interfere with participation in the study; have previously engaged in mindfulness meditation within an 8-week structured protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-9ychtdt	Efficacy of Therapeutic Education in Chronic Shoulder Pain	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8793	Effect of therapeutic education and patient-centered exercise approach on chronic shoulder pain a controlled clinincal trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Volunteers; both genders; age ≥ 18 years; persistent shoulder pain with a predominantly nociplastic and/or nociceptive pain phenotype; diagnosis of subacromial  impingement syndrome/chronic subacromial pain; in the clinical evaluation, obtain 3 positive results out of 5 shoulder impingement tests, namely: Neer&apos;s sign, Hawkins and Kennedy test, empty can test, painful abduction arc, and external rotation resistance test	"limitation of ≥50% of the range of motion for passive internal or external rotation of the shoulder in ≥2 planes of motion; shoulder pain &gt;7/10 on the visual analog scale; pregnancy; cervicobrachialgia confirmed by Spurling Test; any warning signs detected in the initial history, indicating potential signs of tumor, infection, fracture or unreduced dislocation, neurological injury, non-stress-related pain in the shoulder region; history of upper limb fracture; systemic musculoskeletal disease; current or previously diagnosed carcinoma; shoulder surgery; glenohumeral instability; complete tear of any rotator cuff or biceps brachii muscle; acute traumatic shoulder pain; history of analgesic injections less than 3 months ago; cognitive disorders;
Involvement in other exercise-based therapies; more than 4 hours per week of overhead shoulder training activities"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-2hrnx48	Online program to help adolescents reduce ultra-processed food consumption and protect kidney health	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8796	Online educational intervention to reduce the consumption of ultra-processed foods among adolescents: a pragmatic clinical trial focusing on the prevention of Chronic Kidney Disease.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-14	Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Adolescents aged 14 to 19; enrolled in a state public school in Nanuque, Minas Gerais; regular enrollment and attendance; Informed Consent Form signed by parents/guardians; Assent Form signed by the adolescent when applicable.	Cognitive or language impairments that prevent participation or completion of the instruments; transfer to another school during follow-up; refusal to take part in any study stage	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-2n6c247	Efficacy of Laser on therapy of Temporomandibular Disorders in individuals with Headaches	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8797	Efficacy of Low-Level Laser on therapy of Temporomandibular Disorders in individuals diagnosed with Primary Headaches	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Individuals between the ages of 18 and 65, regardless of gender; Be Brazilian; Have a diagnosis of primary headache according to the third edition of the International Classification of Headache Disorders  Agree to answer all survey questionnaires and undergo the necessary treatments for the proposed duration	Individuals with a history of tumors and neuronal involvement; Diagnosis of Temporomandibular disorders concomitant with pain of odontogenic, neuropathic, and/or tumoral origin; Individuals diagnosed with non-painful Temporomandibular disorder; Pregnant women; Individuals with missing front teeth or dentures, making it impossible to measure maximum mouth opening by measuring the distance between the upper and lower incisors	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-6rbbkwm	Online self-care program for facial pain	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8800	Pain science education applied to the management of Temporomandibular Disorders: evaluation of a remote self-care program	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-30	Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Individuals aged 18 years or older; of both sexes; diagnosed with chronic temporomandibular disorder according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); pain intensity greater than or equal to 4 on the Numerical Rating Scale; pain duration of at least three months; access to the internet and an electronic device; ability to read and understand the educational material Facial Pain	Presence of systemic diseases or neurological disorders that may interfere with pain perception; current psychiatric disorders that prevent participation; pregnancy; ongoing treatment for temporomandibular disorder; inability to participate in online sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-6wshhsb	Treatment outcomes of Direct Restorations with Fibers in non-vital front teeth: randomized double-blind clinical trial	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8801	Clinical performance of Direct Fiber-Reinforced Restorations in non-vital anterior teeth: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia da Universidade Federal do Amazonas	<NULL>	<NULL>	<NULL>	Participants of both sexes, aged 18 years or older, in good general and oral health, presenting at least one endodontically treated anterior tooth considered satisfactory, with no clinical or radiographic evidence of periapical lesions; participants must require an extensive restoration of the eligible tooth and present an opposing tooth in functional occlusion	Participants presenting parafunctional habits, such as bruxism; pregnant or breastfeeding women; teeth with pathological mobility, internal or external root resorption, or root fractures; cases with dental morphological alterations, such as fluorosis, amelogenesis imperfecta, dentinogenesis imperfecta, or tetracycline staining, as well as the presence of non-carious cervical lesions; patients undergoing orthodontic treatment; those with an indication for periodontal treatment; or with systemic conditions that may interfere with the prognosis of the treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-10t2kxmq	Evaluation of herbal treatments for the control of menopausal symptoms	Not yet recruiting	Intervention	2026-01-27	<NULL>	<NULL>	8807	Evaluation of the effectiveness of Cimicifuga racemosa and Morus nigra L in the control of climacteric symptoms	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Universidade Federal de Alfenas	<NULL>	<NULL>	<NULL>	Women; aged 45 to 59 years; mentally able to provide their data; with permanent residence in the area covered by the municipality; who are seen in medical consultation during the period from March 02, 2026 to December 05, 2026; who agree to participate in the study and present inclusion characteristics in the study such as: hot flashes, vaginal dryness, anxiety, insomnia, weight gain	Smoking women; using conventional hormone replacement therapy; vegetarians; Asian women not registered by the team in the Medical Specialties Center Care System (CEM)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-6f5jx7p	Use of educational technologies to control urine loss after Prostate Surgery	Not yet recruiting	Intervention	2026-01-28	<NULL>	<NULL>	8808	Effectiveness, feasibility and acceptability of educational technologies in a cognitive-behavioral program for the management of Urinary Incontinence after Radical Prostatectomy: a multicenter clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Men aged 18 years or older; presenting mild, moderate, or severe urinary incontinence, assessed using the Pad test; self-reporting preserved locomotor, visual, and auditory abilities; presenting preserved cognitive function, verified through the Six-Item Cognitive Impairment Test; without a history of urinary incontinence prior to the surgical procedure; presenting absence of postoperative complications such as urethral stricture, urinary retention, rectourethral fistula, or severe urinary tract infection; being without the use of an indwelling urinary catheter for a minimum period of 15 days after surgery, allowing for the development of self-perception regarding clinical conditions and physical adaptation to the postoperative impact; having undergone radical prostatectomy within a maximum of six months; and demonstrating willingness to participate in the scheduled face-to-face meetings	Individuals with spinal cord injury or diseases affecting urinary control; with a history of bladder and/or prostate surgery; reporting not using pads/liners/diapers; initiating chemotherapy or radiotherapy treatment during the intervention period; missing two consecutive face-to-face sessions; hospitalization due to postoperative complications; presenting intercurrences such as infection episodes or urethral stricture; and requiring reinsertion of an indwelling urinary catheter due to bleeding or urinary retention caused by clots	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-10c2zysn	Effects of Two Pilates Method Exercise Protocols on the Treatment of Gestational Lumbopelvic Pain: A Randomized Controlled Trial	Not yet recruiting	Intervention	2026-01-29	<NULL>	<NULL>	8812	Effects of Two Pilates Method Exercise Protocols on the Treatment of Gestational Lumbopelvic Pain: A Randomized Controlled Trial	<NULL>	n/a, n/a, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia – FAEFI/UFU	<NULL>	<NULL>	<NULL>	Pregnant women aged between 18 and 40 years; gestational age between 20 weeks and 0 days and 24 weeks and 6 days at the time of recruitment; clinical diagnosis of lumbopelvic pain with onset in the current pregnancy; pain score equal to or greater than 3 on the 11-point Numerical Rating Scale regarding the last week; presence of clinically relevant functional disability defined by the Roland-Morris Disability Questionnaire with a score equal to or greater than 14; presentation of formal medical clearance from the obstetrician for physical exercise; agreement to participate in the research by signing the Informed Consent Form	Pregnant women with bone deformities ; presence of any other condition causing lumbopelvic pain, such as herniated disc, previous lumbar surgery, and ankylosing spondylitis ; presence of major muscle dysfunctions ; neurological or cognitive impairments that prevent understanding of the proposed procedures ; volunteers visibly under the influence of drugs or alcohol ; current physical injury or medical condition that prevents exercise, such as heart conditions, hypertension, diabetes requiring insulin, kidney disease, cancer, and severe asthma ; conditions that increase the risk of illness, such as epilepsy requiring pharmacotherapy and hyperemesis gravidarum ; regular practice of Pilates, Yoga, or core strengthening in the six months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-3vzkb42	Mobile app to help families increase children’s fruit intake	Not yet recruiting	Intervention	2026-01-29	<NULL>	<NULL>	8815	Digital intervention for promote fruit consumption in children with a focus on parents: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-08-01	Faculdade de Enfermagem da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Parents and/or guardians of children aged 2 to 5 years; who have effective verbal communication skills and access to a mobile device compatible with the application and the internet	Parents and/or guardians of children with any disease or health condition requiring a specific diet; or restricting fruit consumption (as reported by the parents/guardians)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-10mng9xp	Evaluation of vaginal flora, hormonal cytology, and vaginal biopsy in menopausal women comparing the use of non-ablative radiofrequency, CO₂ laser, and vaginal estrogen	Not yet recruiting	Intervention	2026-01-30	<NULL>	<NULL>	8816	Evaluation of the vaginal microbiome, hormonal citology and vaginal histology in postmenopausal women following non-ablative radiofrequency, CO₂ laser therapy, and vaginal estrogen	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-27	Maternidade Escola Assis Chateaubriand / MEAC ( maternidade escola Assis Chateaubriand)/ UFC( universidade federal do Ceará)	<NULL>	<NULL>	<NULL>	Healthy menopausal women; with or without an active sex life; complaints related to genitourinary atrophy	Oncotic cytology with atypical cells precursors to cervical cancer; use of hormone therapy in the last 6 months (topical or systemic); use of vaginal lubricants or moisturizers in the last month; active genital infections	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-3cvt7vb	Laser therapy as a preventive strategy for taste alterations in head and neck Cancer patients undergoing Radiotherapy: a randomized clinical trial	Not yet recruiting	Intervention	2026-01-30	<NULL>	<NULL>	8817	Use of Photobiomodulation to prevent taste alterations in patients with head and neck Cancer undergoing Radiotherapy	<NULL>	2-3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-06	Universidade Federal de Pernambuco	<NULL>	<NULL>	<NULL>	Patients with performance status 0 and 1; aged 18 to 70 years; diagnosed with head and neck cancer; radiation dose of 40 Grays or more	Diagnosis of anemia; uncontrolled diabetes; history of use of medications that significantly altered salivary flow or saliva composition or taste; use of centrally acting analgesics or anxiolytics and antidepressants; resection in the tongue region; tumors in the tongue and base of the tongue and floor of the mouth or nearby regions that make the application of the photobiomodulation protocol unfeasible	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-35cj5s6	Transcranial Electrical Stimulation combined with physical exercise in elderly people with cognitive impairment.	Not yet recruiting	Intervention	2026-01-30	<NULL>	<NULL>	8819	Transcranial Direct Current Stimulation combined with physical exercise in elderly individuals with Mild Cognitive Impairment	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-05	Departamento de Ciências do Movimento Humano- Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Elderly individuals over 60 years of age; female; independent; sedentary and/or insufficiently active; not using an assistive device for walking (e.g., cane or walker), with Mild Cognitive Impairment assessed using the Montreal Cognitive Assessment - MoCA with a cutoff score of 25 points; for individuals with 12 years or less of schooling, one additional point should be added; availability to participate in all treatment and evaluation sessions	Elderly individuals with neurological diseases (e.g., Alzheimer&apos;s, Parkinson&apos;s, Stroke, Vertigo, Dementia); hypertensive individuals; contraindications for the use of Transcranial Direct Current Stimulation - tDCS (e.g., use of psychotropic drugs, history of uncontrolled seizures, presence of metallic implants or electrical devices in the skull, presence of unhealed wounds on the scalp)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-4z8cq3p	Impact of a virtual de platform on occupational stress and metabolic syndrome SeMEar health: a randomized clinical trial	Not yet recruiting	Intervention	2026-02-02	<NULL>	<NULL>	8821	Virtual platform for occupational stress and metabolic syndrome SeMEar health: creation and validation	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade do Estado da Bahia	<NULL>	<NULL>	<NULL>	Age 18 or older; both genders; occupational stress; presence of burnout symptoms (in all three dimensions); metabolic syndrome; willingness to voluntarily participate in the program	Those who participated in another study/body-mind therapy intervention in the last month; pregnant women; those on leave from work; those who do not complete all stages of the intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-109s4k92	Study on the effects of exercise program on unstable versus stable surface in preventing falls and improving balance in elderly women in nursing homes	Not yet recruiting	Intervention	2026-02-03	<NULL>	<NULL>	8823	Comparison of the effects of the Otago program on unstable versus stable surfaces on fall risk and balance in institutionalized elderly women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-20	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Forty elderly women; clinically stable; will be included in the study; divided into two groups: 20 for the Otago group and 20 for the Otago group with an unstable base.	Moderate to severe dementia according to the Mini-Mental State Examination score (include the raw score), uncorrected visual disorders, motor sequelae from neurological disorders or other musculoskeletal conditions that prevent participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-6pjw7g8	Art as a therapeutic resource for alleviating anxiety in elderly residents of long-term care facilities	Not yet recruiting	Intervention	2026-02-04	<NULL>	<NULL>	8826	Art therapy as a tool for reducing Anxiety levels in elderly people living in long-term care facilities: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Cruzeiro do Sul Educacional S.A	<NULL>	<NULL>	<NULL>	Moderate or high levels of anxiety; no cognitive impairment; assessed by the Mini-Mental State Examination (MMSE); no hemodynamic instability; willingness to participate in all intervention sessions; no severe sensory alterations	Elderly individuals with severe communication impairments; Diagnosis of advanced neurodegenerative diseases; Previous and regular participation in art therapy practices; Under pharmacological treatment for anxiety; With severe behavioral changes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-24mkxp8	Use of Dialkyl Carbamoyl Chloride (DACC) to aid in the healing of challenging wounds	Not yet recruiting	Intervention	2026-02-04	<NULL>	<NULL>	8827	Use of Dialkyl Carbamoyl Chloride (DACC) in the prevention and treatment of Hard-to-Heal Wounds	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	<NULL>	<NULL>	<NULL>	Postoperative cardiac surgery patients; both genders; over 18 years of age; who are not immunosuppressed; who do not abuse psychoactive substances	Known allergy or sensitivity to the components of the Dialkyl Carbamoyl Chloride (DACC) dressing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-5gxdv9y	Acute effects of Passiflora incarnata on endothelial function, blood pressure, and heart rate in healthy adults	Not yet recruiting	Intervention	2026-02-05	<NULL>	<NULL>	8829	Acute effect of Passiflora incarnata on endothelial and hemodynamic function in healthy adults: a randomized, double-blind, crossover, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Adults; of both sexes; aged between 18 and 40 years, will be included	Participants will be excluded if they have a history of chronic diseases; are smokers; use medications on a continuous basis that may influence vascular responses; have a known allergy to Passiflora incarnata or to any component of the formulation; use drugs with sedative effects, such as pentobarbital and hexobarbital; anticoagulants such as warfarin; or monoamine oxidase inhibitors (MAOIs), including isocarboxazid, phenelzine, and tranylcypromine, due to their potential to interfere with the hemodynamic responses assessed and to increase the risks involved in the study. In addition, participants who regularly use antioxidant supplements or nitrates, or who have consumed polyphenol-rich foods (e.g., beetroot, chocolate, green tea, citrus fruits) within the 24 hours preceding the experiment will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-108sskhg	The action of Elastic Bandage on pain, edema and functional capacity in women after cesarean section	Not yet recruiting	Intervention	2026-02-05	<NULL>	<NULL>	8835	Effect of Abdominal Taping on pain, edema and functional capacity in women in the immediate post-partum period by cesarean section: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-17	Faculdade de Educação Física e Fisioterapia	<NULL>	<NULL>	<NULL>	Female participants. Age between 18 and 45 years. Be in the immediate postpartum period (first 48 hours). Surgical delivery route (cesarean section) of a single fetus	Presence of significant muscle dysfunctions. Presence of skin lesions in the abdominal region. Presence of dehiscence, necrosis and/or opening of stitches in the scar incision. Allergies to elastic bandage. Presence of neurological and/or cognitive deficiencies that prevent understanding of the proposed procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-7rztcbk	Music to reduce stress and anxiety during the first chemotherapy session in women with Breast Cancer	Not yet recruiting	Intervention	2026-02-05	<NULL>	<NULL>	8836	Efficacy of using Music to reduce stress and anxiety in Breast Cancer patients undergoing their first chemotherapy session: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-05	Karena Cristina da Silva Leal	<NULL>	<NULL>	<NULL>	Patients with breast cancer and HER2-negative disease admitted to the outpatient clinic to undergo neoadjuvant ACT treatment (NSABP B-27) for the first time; beginning oncological treatment at the institution for the first time through the Brazilian Unified Health System; women; aged 18 years or older; and reporting that they enjoy music	Patients with any neurological and/or cognitive impairment that may compromise understanding and the appropriate use of the assessment scale at the required moment; patients with hearing impairment; patients already undergoing continuation of chemotherapy treatment; and patients who use anxiolytics, antidepressants, or lithium on a continuous basis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-6hv63hw	Use of laser on the ear to relieve anxiety after childbirth	Not yet recruiting	Intervention	2026-02-06	<NULL>	<NULL>	8837	Effect of Laser Auriculotherapy on the management of anxiety in postpartum women: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Postpartum women aged 18 years or older; under co-admission in the Kangaroo Neonatal Intermediate Care Unit of the Januário Cicco Maternity School at the Federal University of Rio Grande do Norte; accompanying their newborns; with adequate clinical and cognitive conditions; with time between childbirth and the newborn’s admission to the UCINCa between 48 hours and 10 days	Infection, inflammation, injury, or any anatomical alteration of the auricular pavilion that makes auriculotherapy application unfeasible; planned hospital discharge before completion of the scheduled intervention sessions; refusal to participate in the application of the technique, including the sham modality	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-94p64cm	How to improve nursing support for those struggling to manage their health while living with Human Immunodeficiency Virus: A study based on care theories	Not yet recruiting	Intervention	2026-02-07	<NULL>	<NULL>	8838	Validation of the nursing diagnosis Ineffective Health Self-Management for the care of people living with Human Immunodeficiency Virus in light of a middle-range theory	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-10	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	or conceptual validation nurses or nursing undergraduates with clinical theoretical or research experience with people living with the human immunodeficiency virus and or clinical theoretical or research experience with nursing diagnoses of the North American Nursing Diagnosis Association International will be elected. For clinical validation with nurses all nurses from the Giselda Trigueiro Hospital who voluntarily agree to participate in the research and have an active employment bond with the Giselda Trigueiro Hospital will be included. For clinical validation with patients those who are eighteen years of age or older at the time of collection have a positive diagnosis for human immunodeficiency virus and are hospitalized during the data collection period will be included in the study.	For conceptual validation individuals who do not respond to the research in a timely manner will be excluded. For clinical validation those nursing professionals who are on vacation or are away from professional practice during data collection as well as those who have less than one year of professional experience with People Living with Human Immunodeficiency Virus will be excluded from the research. For exclusion in the patient group patients diagnosed with Human Immunodeficiency Virus and neoplasia neurological comorbidity or similar condition that may affect the result of the collection due to cognitive and speech disability will be adopted patients hospitalized in isolation will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-3smxct4	Study on the effects of cannabinoids in adolescents with attention deficit and hyperactivity disorder	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8843	Potential effects of cannabinoids in adolescents with attention deficit hyperactivity disorder a double-blind randomized controlled clinical trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Sociedade De Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Adolescents of both sexes, aged 12 to 17 years, residing in the Greater Florianópolis region, with a previous diagnosis of attention deficit and hyperactivity disorder confirmed through the SNAP-IV instrument; absence of other severe mental conditions or physical comorbidities; history of previous treatment with other medications without significant improvement of symptoms; agreement to participate in the study through signing of the Informed Consent Form by the legal guardian and the Assent Form by the adolescent	Use of natural or synthetic cannabinoid substances in the month prior to study initiation; history of intolerance to plant components such as confusion, paranoia, pruritus, excessive drowsiness, vomiting, diarrhea or seizures; presence of any physical comorbidities; presence of severe mental disorder not related to the research objective; moderate or severe cognitive impairment; inadequate completion of the study data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-4fvh994	Effect of cold plasma use on pain and chewing during maxillary expansion	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8844	Role of inflammatory mediators, pain perception and masticatory quality in atmospheric cold plasma therapy associated with rapid maxillary expansion: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Volunteers with a clinical diagnosis of unilateral or bilateral posterior crossbite and/or maxillary atresia; Class I or Class II dental malocclusion; first or intertransitional period of mixed dentition; absence of extensive caries lesions and periodontal disease, good general and oral health; absence of previous orthodontic treatment	Volunteers with conditions that compromise oral health at the time of the initial evaluation; with systemic diseases or general health conditions that may interfere with treatment or clinical evaluations; with a history of previous orthodontic treatment; with craniofacial anomalies, genetic syndromes, or cleft lip and palate; continuous or recent use of medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-3csjgb8	Effects of topical application of Silver-Nimesulide Complex in the Treatment of Patients with Squamous Cell Carcinoma of the Skin	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8845	Effects of topical application of Silver-Nimesulide Complex in the Treatment of Patients with Skin Squamous Cell Carcinoma: Phase I/II Study	<NULL>	1-2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-12	Universidade Estadual de Campinas - UNICAMP	<NULL>	<NULL>	<NULL>	Men and women aged 18 years or older and under 90 years; confirmed diagnosis of cutaneous squamous cell carcinoma. Tumors with a minimum diameter of 1cm and superficially located in the skin. Surgical tumor resection previously scheduled; ensuring a minimum interval of 42 days between the initiation of treatment with the silver–nimesulide biocurative (CB-Ag-NMS) and the surgical procedure. Signed or recorded Informed Consent Form (ICF)	Participants with lesions located on the face. Lesions near superficial blood vessels. Ulcerated tumor. Dermatological comorbidities that may interfere with clinical evaluation. Known hypersensitivity to silver; nimesulide or adhesive materials. Pregnant or breastfeeding women. Immunosuppressed individuals. Participants who do not have a previously scheduled tumor resection surgery at the Institution	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-7mmkzt7	Effect of Intraoral Mandibular Advancement Intraoral Appliance (OAm) therapy on Obstructive Sleep Apnea, systemic status,   periodontium of pregnant women and its influence on the fetus and newborn: clinical-laboratory analysis of medical and dental images	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8847	Effect of the Intraoral Mandibular Advancement Device (AIOam) and the Silicone Occlusal Splint (POs) in pregnant women with Obstructive Sleep Apnea and on fetal growth: clinical-laboratory and medical-dental imaging analyses	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Instituto de Ciências e Tecnologia da Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Chronic hypertensive pregnant women with OSA (Apnea-Hypopnea Index AHI &gt; 5 and &lt; 30 events/hour); chronic hypertensive pregnant women with 20 to 22 weeks of gestation; oxyhemoglobin desaturation index (ODI) ≥ 5 events/hour; chronic hypertensive pregnant women aged 20 to 35 years; chronic hypertensive pregnant women with healthy periodontium and absence of caries; nulliparous and multiparous chronic hypertensive pregnant women; sign the Free and Informed Consent Form	Women with pregnancy period &lt; 20 weeks and &gt; 22 weeks with apnea hypopnea index &gt;30/h; with dessaturation index &gt;30/h or with more than 10% of desaturation time &lt;90%; active periodontal disease; severe temporomandibular disorder; drink alcohol; smoke and use drugs; use anti-inflammatory drugs; hormonal therapy; psychiatric disorders; infectious diseases; hematological diseases; clinical history of using orthodontic appliances less than 6 months before the proposed study;  twin pregnancies; using antidepressants; using in vitro fertilization	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5yk8j2w	How Pilates training on equipment can improve functional capacity, quality of life, balance, and muscle strength in very old adults: a controlled clinical study	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8850	Effects of Pilates training using equipment on functional capacity, quality of life, balance, and muscle strength in long-lived elderly individuals: a controlled clinical trial	<NULL>	n/a, non-randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Universidade Federal do Amazonas	<NULL>	<NULL>	<NULL>	male and female individuals aged 80 years or older, proven by presenting an official document at the time of enrollment	Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, walker, crutch, metallic knee and hip prostheses, visual impairment, wheelchair user	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-8kyp7kz	Therapeutic Light to ease Pelvic Pain and improve women’s quality of life	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8851	Effect of Photobiomodulation on Chronic Pelvic Pain and quality of life in women of reproductive age: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Ciências da Saúde do Trairi	<NULL>	<NULL>	<NULL>	Women aged 18 to 49 years who report chronic pelvic pain will be included in this study. Participants must report non-cyclical pain located in the pelvic region, with a duration of at least 3 months, and must be available to attend the in-person sessions according to the study schedule.	Women will be excluded if they present malignancy (cancer); epilepsy; cardiac arrhythmia; cognitive impairment; difficulty understanding instructions and/or using the assessment instruments; history of pelvic surgery within the past year; chronic infection; pregnancy; intact hymen. Participants included in the study must not be undergoing any other type of treatment for chronic pelvic pain, except for pharmacological treatment.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-10jx5y6r	Efficacy and safety of hyaluronic acids Juvederm Volux® and Restylane Shaype® in filling the chin	Not yet recruiting	Intervention	2026-02-10	<NULL>	<NULL>	8856	Efficacy and safety of Juvederm Volux and Restylane Shaype in filling the chin region: a clinical study, randomized and double-blind	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Centro Universitário Ingá - UNINGÁ	<NULL>	<NULL>	<NULL>	Volunteers with complaint of chin retrusion, classified as levels II - III on the Galderma chin retrusion scale (GCRS); no previous aesthetic treatments in the mental region.	Volunteers who are pregnant or breastfeeding; with hypersensitivity to hyaluronic acid; who have received aesthetic treatments in the medial and lower region of the face in the last year; who present with autoimmune diseases.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-6k4mk3b	Randomized and comparative study on surgical treatment of Apical Vaginal Prolapse: abdominal vs. vaginal approach	Not yet recruiting	Intervention	2026-02-11	<NULL>	<NULL>	8858	Randomized study comparing two main surgical approaches in the treatment of Vaginal Prolapses	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women; age 18 years or older; symptomatic apical prolapse; apical prolapse stage II to IV by the POP-Q system; with surgical indication; desire to participate in the study.	Previous neurological disease; apical prolapse stage I or less according to the POP-Q system; previous vaginal prolapse surgery; previous pelvic radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5yh6xkx	Postoperative sensitivity of posterior restorations using a rapid high-intensity light-curing system: a clinical trial	Not yet recruiting	Intervention	2026-02-11	<NULL>	<NULL>	8859	Postoperative sensitivity of restorations of posterior teeth using a rapid high-intensity light-curing system: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-03	Universidade Estadual de Ponta Grossa	<NULL>	<NULL>	<NULL>	Participants aged between 18 and 70 years; participants must present at least two Class I or Class II restorations in vital teeth; cavities should present similar dimensions and a minimum depth of 3 mm; participants must have at least 20 teeth in functional occlusion; the selected teeth must present adequate proximal contact and confirmed vitality; eligible teeth will include carious lesions or defective existing restorations requiring replacement	Participants with unsatisfactory oral hygiene; participants with chronic or advanced periodontitis; participants that are undergoing fixed orthodontic treatment; exhibit significant occlusal wear in more than 10 posterior teeth; or require endodontic treatment; participants with a history of allergy to any materials used in the protocol; pregnant and lactating women; participants who regularly use anti-inflammatory drugs, analgesics, or psychotropic medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-2g42hz7	Transvaginal radiofrequency to treat vaginal symptoms of menopause	Not yet recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8867	Transvaginal radiofrequency to treat geniturinary syndrome of Menopause: Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Pontifícia Universidade Católica do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Menopause. Diagnosis of geniturinary síndrome of menopause	Previous pelvic radiotheray. Women using pacemaker	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6v2mz6f	Polidocanol foam with or without transdermal laser for the treatment of varicose veins	Not yet recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8868	Clinical and Aesthetic Efficacy of Polidocanol Foam Sclerotherapy Associated or Not With Transdermal Nd:YAG Laser in Lower Limb Varicose Veins: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade do Estado do Rio de Janeiro (UERJ) – Hospital Universitário Pedro Ernesto (HUPE)	<NULL>	<NULL>	<NULL>	Age between 21 and 75 years of both sexes. Superficial lower limb tributary varicose veins with a diameter between 2.5 mm and 4.0 mm assessed in the standing position. Tributary vein depth up to 4 mm measured from the anterior wall of the vein to the skin surface. Tributary varicose veins related to the saphenous vein provided that the saphenous vein is competent on Doppler ultrasound. CEAP clinical classification 1 to 3. Body mass index less than 35 kg/m². Signed informed consent form.	Body mass index greater than 35 kg/m². Saphenous vein incompetence requiring prior treatment. CEAP clinical classification 4 to 6. Active venous thromboembolic disease or history of deep vein thrombosis. Active malignancy or immunosuppression. Active rheumatologic diseases or lymphedema. Known allergy to polidocanol. Skin lesions at the site of the vein to be treated. Pregnancy or postpartum period. Inability to understand or sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-23xg9py	Resistance Training with Blood Flow Restriction: Impacts on Function and Muscular Architecture in Upper Limbs	Not yet recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8870	Impact of a Blood Flow Restriction Training on Strength and Muscular Architecture in Upper Limbs	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Estadual Paulista - Faculdade de Filosofia e Ciências -  Campus de Marília	<NULL>	<NULL>	<NULL>	That will be recruited healthy adult volunteers of both sexes, aged 18 to 35 years, who are sedentary or occasionally active in recreational physical activities (standardized based on accelerometry assessment), and with no history of cardiovascular, neuromuscular, or metabolic diseases	Non-inclusion criteria will include the use of medications that influence muscle function, smokers, pregnant women, individuals with recent upper limb injuries, any contraindication to physical exercise, or any previously diagnosed vascular condition. Individuals who consume stimulants, such as caffeine and alcohol, 24 hours prior to the assessments will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-5yy4p9f	Effect of enamel-derived matrix proteins used at different concentrations on bone repair in sinus floor elevation with ceramic material	Not yet recruiting	Intervention	2026-02-16	<NULL>	<NULL>	8877	Effect of enamel-derived matrix proteins at different concentrations on bone repair in sinus floor elevation with biphasic ceramic material - A Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with age be between 18 and 60 years; Patients who require unilateral or bilateral maxillary sinus floor elevation for subsequent placement of osseointegrated implants; Patients must have bone availability associated with the alveolar ridge adjacent to the maxillary sinus less than or equal to 3mm; Patients with good systemic health; Patients that present at least 4 months of post-extraction alveolar healing	Smokers; Uncontrolled diabetics; Patients with chronic or aggressive periodontitis; Patients using medications that alter bone metabolism; Patients with chronic upper respiratory tract infections; Patients who chronically use anti-inflammatory drugs and antibiotics; Patients with bruxism; Alcoholics; Substance abusers; Pregnant women or those wishing to become pregnant in the next year; History of radiotherapy treatment in the head and neck region; Patients with pathologies affecting bone metabolism; Patients who have experienced a large rupture of the sinus membrane during surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6xmsq84	Use of a solution to prevent infections in mouth and throat surgeries	Not yet recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8879	Evaluation of the Efficacy of Prontosan® in Reducing Surgical Site Infections in Upper Aerodigestive Tract Surgeries	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Instituto de Câncer Arnaldo Vieira de Carvalho	<NULL>	<NULL>	<NULL>	Male and female patients aged 18 years or older; histopathologically confirmed diagnosis of squamous cell carcinoma of the oral cavity, lip, oropharynx, hypopharynx, or larynx; candidates for surgery with curative intent, with or without the need for reconstruction; ability to provide a signed Informed Consent Form (ICF)	Active infection at the time of screening; recent use of antibiotics within the last 14 days prior to surgery; severe immunosuppression defined as chronic use of corticosteroids in immunosuppressive doses, recent myelosuppressive chemotherapy or diagnosis of primary or secondary immunodeficiency such as Human Immunodeficiency Virus (HIV) with CD4 count less than 200 cells per cubic millimeter; previous radiotherapy in the proposed surgical region; need for reoperation at the same surgical site; surgery without curative intent such as palliative surgeries; known allergy to any component of the Prontosan solution such as polyhexanide or betaine; inability to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-2snq3hw	Effect of early high-fat tube feeding on intestinal recovery in hospitalized patients	Not yet recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8883	Impact of early lipid-rich postpyloric enteral nutrition on the intestinal microbiome and functional recovery in patients with intestinal failure	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital Universitario de Caldas	<NULL>	<NULL>	<NULL>	Adult patients aged 18 years or older; patients undergoing major abdominal surgery; admission to the intensive care unit in the immediate postoperative period; diagnosis of acute intestinal failure type I; catabolic response to surgical trauma; medical indication for initiation of early enteral nutrition within the first 24 hours after surgery; hemodynamic stability without requirement for high-dose vasopressors; written informed consent signed by the patient or legal representative	Age under 18 years; chronic intestinal failure or short bowel syndrome; uncontrolled sepsis or septic shock at the time of inclusion; hemodynamic instability defined by norepinephrine requirement greater than 0.1 micrograms per kilogram per minute or vasopressin greater than 1 unit per hour; previously diagnosed inflammatory bowel disease; mechanical intestinal obstruction; intestinal ischemia; active gastrointestinal bleeding; prolonged use of systemic antibiotics for more than 14 days prior to inclusion; clinical or technical contraindication to postpyloric tube placement; pregnancy; concurrent participation in another interventional clinical trial	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-4d6mpkz	Impact of Heart Health Images on Eating and Exercise Habits of University Staff	Not yet recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8885	Effect of Pictorial Cardiovascular Health Communication on dietary and physical activity behaviors among workers of a public university	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Active workers who were part of the previous matrix study; aged between 20 and 59 years; from the teaching, research, or administrative staff careers at a public university	Workers on sick leave; maternity leave	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-23vmpsx	Yoga in Elderly Hypertensive Patients	Not yet recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8888	Effect of Yoga on Blood Pressure in Elderly Hypertensive Patients: A Multicenter Randomized Control Group Study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Instituto do Coração do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	The inclusion criteria are: age 65 years or older; diagnosis of stage 1 or 2 hypertension for more than 6 months; brachial blood pressure measured in the office of less than or equal to 140/90 mmHg under stable antihypertensive medication for at least 2 months; ability to participate in light to moderate physical activity; and provision of free and informed written consent	Exclusion criteria include persistent or permanent atrial fibrillation; insulin-dependent diabetes mellitus; chronic kidney disease with estimated glomerular filtration rate &lt;30 mL/min/1.73 m²; previous stroke; heart failure with left ventricular ejection fraction &lt;40%; recent myocardial infarction (&lt;6 months); symptomatic coronary artery disease; complex ventricular arrhythmias; current smoking; severe cognitive impairment or dementia; musculoskeletal or peripheral vascular conditions limiting exercise; body mass index &gt;35 kg/m²; secondary hypertension; or regular yoga practice within 90 days before study entry	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-5t6m6jh	Comparison of two pain control techniques after minimally invasive kidney removal surgery	Not yet recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8890	Comparison of postoperative analgesia between Quadratus Lumborum Block and Intrathecal Morphine in patients undergoing Minimally Invasive Nephrectomy: a prospective randomized study	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	AC Camargo Cancer Center	<NULL>	<NULL>	<NULL>	Adult patients classified as American Society of Anesthesiologists (ASA) physical status I–III undergoing elective laparoscopic partial nephrectomy at the AC Camargo Cancer Center hospital complex	Obese patients (Body Mass Index &gt; 30); patients with ASA physical status &gt; III; those with contraindications to spinal anesthesia or quadratus lumborum block; patients with cognitive impairment precluding reliable assessment using the visual analog scale for pain; patients who develop severe clinical or surgical complications; patients with allergy to morphine or ropivacaine; and patients who refuse to provide written informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-8rhdjw4	Physiotherapy exercises to improve muscle strength and breathing in people with chronic kidney disease before dialysis: clinical study	Not yet recruiting	Intervention	2026-02-22	<NULL>	<NULL>	8897	Integration of multidimensional physiotherapeutic strategies in the treatment of respiratory and uremic sarcopenia in patients with Chronic Kidney Disease in the pre-dialysis stage: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-15	Departamento de Fisioterapia	<NULL>	<NULL>	<NULL>	Patients with pre-dialysis stage chronic kidney disease, confirmed by clinical or laboratory criteria as prescribed by the National Kidney Foundation, will be included; of both sexes; aged between 30 and 70 years; clinically stable and without recent exacerbations; with the ability to understand and participate in the proposed assessment and exercise program	Patients undergoing renal replacement therapy such as hemodialysis, peritoneal dialysis, or kidney transplantation; those with acute or chronic respiratory diseases; those with neurological and/or musculoskeletal conditions that interfere with performing respiratory exercises; those with cognitive or behavioral impairments that prevent participation in the study or compliance with protocol instructions; and those with any other medical condition that makes them ineligible to participate in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-9hdghd3	Esmolol or Remifentanil: a comparison of medications during maxillofacial surgery and patient recovery	Not yet recruiting	Intervention	2026-02-25	<NULL>	<NULL>	8903	Evaluation of intraoperative parameters and quality of postoperative recovery in maxillofacial surgeries with continuous infusion of Esmolol versus Remifentanil: a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-06	Empresa Brasileira De Servicos Hospitalares	<NULL>	<NULL>	<NULL>	Age from 18 years; both genders; American Society of Anesthesiology (ASA) I or II; elective oral and maxillofacial surgery with expected duration between 1h and 3h; signed Free and Informed Consent	Previous diagnosis of atrioventricular block; cardiovascular disease that compromises the use of beta-blockers; diagnosis of asthma or Chronic Obstructive Pulmonary Disease; regular use of opioids; patients with chronic pain	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-249pj8m	Evaluation of educational activities to support caregivers of older adults with dementia in primary health care units	Not yet recruiting	Intervention	2026-02-25	<NULL>	<NULL>	8908	Evaluation of educational workshops for caregivers of older adults with alzheimer’s disease in primary health care	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-09	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Age 18 years or older; performing caregiving activities for at least three months; not receiving remuneration for providing care	Inability to read; older adult under care not registered with or not followed by a primary health care unit participating in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-449rqqm	Lactational Mastitis associated with the use of Low-Intensity Laser Therapy in women treated at a human milk bank	Not yet recruiting	Intervention	2026-02-24	<NULL>	<NULL>	8910	Clinical trial on the occurrence of mastitis in lactating women attended at a human milk bank	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Centro de Ciências da Saúde da Universidade Estadual de Maringá	<NULL>	<NULL>	<NULL>	Women of any age, if a minor accompanied by a guardian, who have given birth within the Unified Health System (SUS); who are breastfeeding for up to six months; who have a diagnosis of classic mastitis, characterized by the presence of at least three signs or symptoms compatible with the diagnosis; or who are using antibiotics for a maximum of 48 hours	Lactating women with mastitis of other etiologies; cases associated with the presence of a breast abscess or area of ​​fluctuation; clinical situations that contraindicate the use of photobiomodulation (such as neoplasms, use of photosensitive drugs, pregnancy, undiagnosed lesions, tattoos or micropigmentation in the affected area); those who have given birth in private services; those who have been breastfeeding for more than six months and have been using antibiotics for more than 48 hours	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-3mxk7tc	Dental implants enhance denture stability in diabetic patients: Practical and random study	Not yet recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8911	Retention of lower complete dentures by dental implants in diabetic patients: A randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	The inclusion criteria for this study will be: Patients with type I or type II diabetes; Patients who are completely edentulous in the lower arch; Patients who do not wear prostheses or who have inadequate complete dentures; Patients that was submitted to tooth extractions at least 12 months prior to the rehabilitation procedure (completely edentulous for at least 1 year); Patients between 40 and 70 years old	Patients with the following characteristics will be excluded from this study: Partial of dentate patients; Smokers who smoke more than 10 cigarettes per day; Users of medications that alter bone metabolism; Pregnant or breastfeeding; 6) patients who do not understand the terms of the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-874hqcw	Resonant leadership development in nurses: effects on missed nursing care and staff turnover	Not yet recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8915	The effect of an educational intervention based on nurses’ resonant leadership on missed nursing care and staff turnover: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-02	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Nurses who meet the following inclusion criteria will be invited to participate in this study: (1) having an active institutional employment relationship for at least three months, considering this period as the minimum experience required by the institution for professional adaptation and integration into the work routine; (2) working in inpatient units (medical and surgical) or intensive care units; and (3) having proficiency in the Portuguese language, as it will be the language used to conduct the educational intervention. For sample selection, non-probabilistic convenience sampling will be used, with the aim of measuring and comparing the frequency with which resonant leadership is perceived by the participants.	Nurses with less than three months of employment at the institution, those who attend less than 75% of the educational intervention, and/or those who do not complete all stages of the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-10nhhm4v	Diet and blood Magnesium, Selenium, Folate, Omega-3 and Omega-6 levels in patients with chronic facial pain	Not yet recruiting	Observational	2026-02-26	<NULL>	<NULL>	8921	Food intake and serum levels of Magnesium, Selenium, Folate, Omega-3 and Omega-6 in patients with Chronic Painful Temporomandibular Dysfunction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-05	Departamento de Odontologia Restauradora da Universidade Federal do Ceará Campus Fortaleza	<NULL>	<NULL>	<NULL>	The volunteers will be female; aged between 20 and 45; seeking treatment at the Dentistry course at the Federal University of Ceará; as well as from the general population, recruited through social media and posters; present painful complaints of at least 5, measured on a Numerical Scale ranging from 0 (no pain) to 10 (worst possible), for at least 3 months and with no history of previous treatment for at least three months; the healthy group will consist of women without Temporomandibular Disorders and with no previous history of facial pain complaints	Women with previously diagnosed disabling cognitive, psychological, and neurological disorders;  in addition to a previous diagnosis of chronic kidney disease, liver disease, megaloblastic anemia, or cancer, other chronic painful disorders; abuse of legal drugs and/or alcohol, use of illegal drugs; pregnant and lactating women; volunteers who had lost five or more teeth, poorly fitting dentures, severe periodontal disease, toothache, intraoral or extraoral lesions capable of compromising masticatory function; use of multivitamins or isolated supplements containing magnesium or selenium in the last 30 days; those with systemic conditions likely to cause dietary restrictions, such as lactose intolerance, gluten intolerance, diabetes mellitus, severe irritable bowel syndrome, and inflammatory bowel disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-65ynybq	Effectiveness of a Behavioral Approach to Physical Activity in Adults	Not yet recruiting	Intervention	2026-03-02	<NULL>	<NULL>	8925	Effectiveness of a Behavioral Intervention in Physical Activity Practice Among Adults	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Escola de Educação Física e Esporte da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Aged between 40 and 70 years. Active staff member of the University of São Paulo with a weekly workload greater than 30 hours. Reporting less than 150 minutes per week of moderate intensity physical activity. Availability to participate in all stages of the 16 week protocol	Medical contraindications to moderate intensity physical activity identified during initial screening using the Physical Activity Readiness Questionnaire and health history assessment. Pregnancy or planned extended leave from work during the study period. Participation in another formal physical activity program involving more than 150 minutes per week of moderate intensity physical activity. Refusal to use monitoring devices including triaxial accelerometer and smartband	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-10dt7q8m	Innovative treatment for chronic pain relief	Not yet recruiting	Intervention	2026-03-02	<NULL>	<NULL>	8926	Scrambler therapy in the management of chronic pain	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-26	Centro Universitário das Faculdades Associadas de Ensino - FAE/UNIFAE	<NULL>	<NULL>	<NULL>	Adults between 18 and 65 years of age of both sexes with a clinical diagnosis of chronic low back pain for at least 3 months will be included	Individuals with previous lumbar surgeries; pacemaker use; pregnant women; individuals with severe neurological diseases; presence of systemic inflammatory processes; cancer diagnosis; those involved in labor litigation related to low back pain will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-59xgczn	Effects of a home-based exercise preparation program on the physical and emotional health of people with Obesity waiting for stomach reduction surgery	Not yet recruiting	Intervention	2026-03-03	<NULL>	<NULL>	8932	Effects of a home-based prehabilitation program on the physical and psychological aspects of individuals with Obesity waiting for metabolic and bariatric surgery	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade do Estado de Santa Catarina - UDESC	<NULL>	<NULL>	<NULL>	People of both sexes; 18 years of age or older; with grade III (severe) obesity; body mass index (BMI) &gt; 40 kg/m2; indication for bariatric surgery; formal indication for preoperative physiotherapy; absence of comorbidities that compromise the safety or ability to perform physical and functional tests applied in the study (e.g., six-minute walk test, 5-repetition chair stand-up test)	History of previous bariatric surgery; previous clinical diagnosis of acute or chronic respiratory diseases that may compromise the safety of physical tests (e.g., COPD, asthma with remodeling); abdominal or thoracic surgeries performed in the last year; pacemaker use; history of myocardial infarction in the last three months or unstable angina pectoris; sustained or episodic cardiac arrhythmias that may be aggravated by physical activity; symptomatic peripheral vascular disease; any other clinical condition that, at the discretion of the responsible investigator, represents a risk or impossibility of participation in the study; abuse of or chemical dependence on psychoactive substances (including alcohol and illicit drugs), according to clinical criteria and/or previous diagnosis; cognitive and physical alterations that prevent the performance of the tests	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6ybhq2y	Hormone therapy and healing of dental implants in transgender individuals	Not yet recruiting	Observational	2026-03-04	<NULL>	<NULL>	8938	Evaluation of osseointegration and healing of dental implants with prosthetic loading in transgender individuals with and without hormone therapy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-25	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Individuals aged between 18 and 60 years; transgender individuals classified according to gender identity as trans men or trans women; using or not using gender-affirming hormone therapy (gaht); with clinical indication for oral rehabilitation through dental implants; presenting good general systemic health	Refusal to sign the informed consent form (icf); uncontrolled diabetes mellitus; active chronic or aggressive periodontal disease; continuous use of medications that interfere with bone metabolism such as corticosteroids or bisphosphonates; chronic infections of any nature; prolonged use of anti-inflammatory drugs or antibiotics; severe bruxism; current pregnancy or planning pregnancy within the next year; previous radiotherapy in the head and neck region; metabolic or systemic diseases affecting bone metabolism	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6nffmc2	Use of virtual reality, therapeutic play, and music for pain relief during vaccination in children aged 4 to 6 years	Not yet recruiting	Intervention	2026-03-04	<NULL>	<NULL>	8939	Effect of virtual reality, instructional therapeutic play, and music therapy versus usual care on pain during vaccination in children aged 4 to 6 years: a pilot randomized clinical trial protocol	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Universidade Estadual de Feira de Santana	<NULL>	<NULL>	<NULL>	Age 4 to 6 years 11 months and 29 days. Both sexes. Child awake. Child accompanied by parents or legal guardian over 18 years of age capable of consenting and native Portuguese speaker. No analgesics or sedatives received in the 12 hours prior to enrollment. Indication for varicella vaccine	Fever ≥ 37.5°C on the day. Undergone needle interventions on the same day. Diagnosed with cognitive deficit or any psychiatric condition such as autism depression or anxiety. Severe neurological conditions that alter behavioral assessment such as epilepsy cerebral palsy or seizures. Withdrawal by the guardian. Visual or hearing impairment. Oculomotor and convergence disorders such as strabismus or nystagmus. History of migraine or labyrinthitis. Head injuries preventing painless placement of VR glasses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-95ptyjx	Music Therapy for impulsivity in Parkinson’s Disease: a clinical trial	Not yet recruiting	Intervention	2026-03-04	<NULL>	<NULL>	8941	Effect of Music Therapy on Inhibitory Control in Parkinson&apos;s Disease: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal do Paraná - Ciências Humanas e Sociais	<NULL>	<NULL>	<NULL>	Participants with an established diagnosis of idiopathic Parkinson’s disease; at stages one to three on the Hoehn and Yahr scale; with a score equal to or greater than 24 on the Montreal Cognitive Assessment (MoCA); of both sexes	Participants diagnosed with other neurological disorders; visual and/or auditory deficits that compromise the understanding and performance of the activities; and participants who are currently receiving therapeutic treatment for cognitive disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-8k2tq29	Differences between dentures made the traditional way and those made with 3D printing	Not yet recruiting	Intervention	2026-03-04	<NULL>	<NULL>	8942	Conventional complete dentures vs. 3D-printed complete dentures	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Participants who have been completely edentulous for at least 1 year; individuals seeking oral rehabilitation at the complete denture service at the Faculty of Dentistry of Pernambuco (FOP/UPE); participants who agree to participate in this research by signing the Informed Consent Form; participants over 18 years of age; both sexes; participants classified as class 1 or class 2 in the Dental Prosthesis Diagnostic Index for complete edentulism; participants with sufficient systemic health to attend clinical appointments and the discernment to answer the questionnaires	Individuals with retentive ridges (indication for surgery); individuals with neoplastic and non-neoplastic proliferative processes in the oral mucosa; individuals with alterations in the oral mucosa resulting from microbial infections; individuals with neuromuscular disorders.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-49rgf8h	Women, Immunology, Nutrition and Exercise (WINE project)	Not yet recruiting	Observational	2026-03-05	<NULL>	<NULL>	8946	Women, Immunology, Nutrition and Exercise (WINE project): An approach to female physiology focusing on sex hormone receptors and monocyte morphofunctionality according to reproductive phases	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Estadual Paulista Julio de Mesquita Filho	<NULL>	<NULL>	<NULL>	Healthy women; Regular menstrual cycle for women in the reproductive phase; Non-users of hormonal contraceptive methods; Non-dependent on hormone replacement	When these inclusion criteria are not met, volunteers will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-2th4cc3	The impact of audiovisual stimulation with brain frequencies on the health of adults with mild cognitive impairment	Not yet recruiting	Intervention	2026-03-05	<NULL>	<NULL>	8950	The impact of audiovisual stimulation with gamma and theta frequencies on cognitive, mental, and physical health and blood BDNF concentrations in adults with mild cognitive impairment: a randomized multicenter clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-15	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 50 and 69 years; diagnosed with mild cognitive impairment (MCI); possessing a score higher than 12, without a diagnosis of dementia, and lower than 26 points on the MoCA test.	Individuals with epilepsy; immunocompromised individuals; those with oncological and infectious diseases; those diagnosed with bipolar disorder; those with pacemakers; and participants with hypersensitivity to light.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-8ngp7d6	Using virtual reality and partial body weight support to improve walking after stroke	Not yet recruiting	Intervention	2026-03-06	<NULL>	<NULL>	8952	Impact of Virtual Reality Combined with Partial Body Weight Support on Gait Rehabilitation after Stroke	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants of both sexes; aged between 40 and 75 years; post-stroke in the chronic phase more than 6 months after the event; with hemiparesia; independent walking ability without use of assistive walking devices for at least 10 meters; ability to understand commands; body weight equal to or greater than 30kg	Participants presenting other significant neuromuscular and orthopedic conditions that may interfere with gait or contraindications for virtual reality use such as photosensitive epilepsy or severe cognitive impairment; participants will be excluded who present persistent motion sickness cyber-nausea after the acclimation period or serious adverse events during the session such as severe dizziness or extreme fatigue	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-7fgjdxb	A double-blind randomized clinical evaluation of a bulk-fill resin composite in posterior restorations	Not yet recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8954	Clinical evaluation of a fast and high-power curing bulk-fill resin composite in posterior restorations: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-03	Universidade Estadual de Ponta Grossa	<NULL>	<NULL>	<NULL>	Participants aged 18–70 years; participants clinically healthy; participants presenting at least 20 teeth in occlusion and an acceptable level of oral hygiene; each participant must require at least two Class I or II restorations in vital teeth with cavities of similar horizontal and vertical dimensions; the selected teeth must present functional occlusion with the natural antagonist tooth and proximal contact with adjacent teeth; pulp vitality will be confirmed by means of a thermal test using a cold spray and periapical radiography; a positive response will be considered when it occurs within 10 seconds after stimulus application and is characterized by mild, short-lasting pain, consistent with a vital pulp	Participants that present unsatisfactory oral hygiene characterized by a Simplified Oral Hygiene Index  greater than 3; participants diagnosed with chronic or advanced periodontitis, defined as probing depth greater than 4 mm, presence of bleeding on probing, participants with clinical attachment loss greater than 3 mm in more than four teeth; participants with fixed orthodontic appliances; participants that present significant occlusal wear in more than 10 posterior teeth; participants that require endodontic treatment; participants that presente hypersensitivity to resin-based composite materials or to any other materials used in this study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-10w97w8r	Use of laser in the management of muscle pain in patients with temporomandibular dysfunction	Not yet recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8957	TMD and orofacial pain (OP)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Centro de Pesquisas Odontológicas São Leopoldo Mandic	<NULL>	<NULL>	<NULL>	Participants of both sexes; Aged between 18 to 75 years; Participants diagnosed with bilateral Myalgia-type Temporomandibular dysfunction	Participants with symptoms of Anxiety or Depression; participants identified using a screening instrument; participants who have taken any medication to control Temporomandibular dysfunction  in the 3 months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-10qwh849	Graft derived from the patient’s own blood to enhance the healing of complex wounds.	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8959	Autologous Fibrin Matrix Therapy in the Treatment of Individuals with Complex Wounds.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-09	Centro de Ciências da Saúde - Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Be over 18 years of age; regardless of gender; have a medical diagnosis of Diabetes Mellitus with a foot ulcer or lesion resulting from foot amputation related to Diabetes Mellitus; not be undergoing treatment with Autologous Leukocyte Platelet Fibrin Matrix; be available to attend the health service once a week	Pregnancy; lesions suspected of being malignant; significant anemia; wound with active bleeding; continuous use of anticoagulant medication; Ankle Brachial Index values ​​indicating severe ischemia; active infection; antibiotic use in the last month; chronic kidney disease; blood borne diseases; ulcers larger than 49 cm2; individuals with any type of reported allergy to the products of the therapies used in treatment (dressings/wound dressings)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-7dv562m	Effect of a Personalized Dietary Intervention on the Recovery of Children after Tonsillectomy and Adenoidectomy	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8960	Impact of a Personalized Dietary Intervention on the Recovery of Children After Adenotonsillectomy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-15	Centro Integrado de Saúde Amaury de Medeiros - CISAM/UPE	<NULL>	<NULL>	<NULL>	Children of both sexes; age between five and ten years; confirmed medical indication for adenotonsillectomy due to obstructive sleep apnea, recurrent upper airway infections or other conditions associated with hypertrophy of the tonsils and adenoids, including mouth breathing syndrome; nutritional status classified as eutrophic, mild undernutrition or overweight according to body mass index for age expressed as Z score; preserved functional capacity; respiratory function within normal parameters for age, except for alterations related to tonsil and adenoid hypertrophy; legal guardians committed to adherence to the intervention protocol and participation in follow-up assessments; written informed consent signed by legal guardians	Hemodynamic instability; presence of chronic respiratory diseases in exacerbation, including asthma, cystic fibrosis or chronic bronchitis; acute respiratory infection within thirty days prior to the intervention, including pneumonia or bronchiolitis; congenital or acquired heart diseases; metabolic disorders such as type one or type two diabetes mellitus and hypothyroidism; regular use of corticosteroids or continuous use of bronchodilator medication; severe undernutrition or morbid obesity; previous specific nutritional follow-up; occurrence of severe complications during or after adenotonsillectomy, including hemorrhage or severe infections; need for surgical reintervention or prolonged mechanical ventilation; absence of informed consent from legal guardians	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3s3dkp3	The effect of Haloperidol on the survival of patients with severe infection	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8961	Effects of Haloperidol on mortality in septic shock: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	The inclusion criteria will be individuals over 18 years of age, of both sexes, admitted with a diagnosis of septic shock and on mechanical ventilation (MV) to the Intensive Care Unit of the Hospital das Clínicas of the Faculty of Medicine of Botucatu (HC/FMB) between March 2026 and February 2028	Pregnant women, patients with brain death or in palliative care, those with other types of shock (cardiogenic, hemorrhagic), those with a prolonged QTc interval on the electrocardiogram (greater than or equal to 450 ms for men and greater than or equal to 470 ms for women), as well as those whose legal representative/family member does not consent to participation by signing the Informed Consent Form (ICF), will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-3m74jj8	How lifestyle changes can improve health and performance in healthcare professionals	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8963	How healthy habits can improve the body well-being and performance of healthcare professionals	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Hospital Israelita Albert Einstein	<NULL>	<NULL>	<NULL>	Healthcare professionals; both sexes; age between 18 and 65 years; active professional link with the institution; day, evening, or night work shift; agreement to participate and provision of written informed consent; clinical ability to participate in a lifestyle change program including nutritional guidance and encouragement of physical activity.	Uncontrolled chronic diseases; clinical or physical conditions that prevent safe participation in a lifestyle change program including nutritional guidance and encouragement of physical activity; use of medications that significantly interfere with body weight or body composition; pregnancy; breastfeeding; concurrent participation in another intervention study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-10dq3wsm	Video about Self-care guidelines for Feet for People with Diabetes	Not yet recruiting	Intervention	2026-03-11	<NULL>	<NULL>	8964	Webcast on Foot Self-Care for People with Diabetes: Multimethod Study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-08	Fundação Universidade Estadual do Ceará	<NULL>	<NULL>	<NULL>	To be 18 years of age or older. To have a medical diagnosis of diabetes for at least six months. To be under regular follow-up at a Primary Health Care Unit (PHCU). To have or not have foot injuries. To have access to a landline or mobile phone	Those who do not have 20 to 30 minutes available to watch the video. those who answer the data collection instrument incompletely. those with visual or auditory impairment. cognitive impairment or any condition attested in their medical record that prevents concentration and viewing of the webcast. those who did not answer calls after four consecutive attempts. as well as those who changed their phone number during the course of the study were excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-6pfv9fb	Health Education and Exercise Program for Hip Flexibility or Leg Strengthening in people with Knee Osteoarthritis	Not yet recruiting	Intervention	2026-03-11	<NULL>	<NULL>	8966	Protocol for a Feasibility Study of a Randomized Clinical Trial comparing a Health Education Program and Hip Flexibility Exercises versus a Lower Limb Strengthening Program in individuals with Knee osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-12	Departamento de Fisioterapia	<NULL>	<NULL>	<NULL>	Individuals aged between 40 and 80 years, of both sexes; report of knee pain lasting longer than six months; pain intensity equal to or greater than 4 on a 0 to 10 numeric pain rating scale; diagnosis of knee osteoarthritis confirmed by radiography and classified as grades II, III, or IV according to the Kellgren and Lawrence classification; availability to undergo bilateral knee radiographs	Presence of uncontrolled cardiovascular diseases; medical report contraindicating moderate-intensity physical exercise; cognitive impairment preventing understanding of assessment protocols; diagnosis of fibromyalgia or rheumatoid arthritis; body mass index equal to or greater than 30 kg/m²; participation in exercise under medical prescription; regular physical activity more than twice per week in the last six months; continuous walking longer than 30 minutes daily; diagnosis of hip osteoarthritis; presence of ligament injuries or tendinopathies in lower limbs; history of knee joint surgery; corticosteroid injection in the knee or hip within the last six months; report of pain in the hip, ankle, foot, or lumbar spine with intensity greater than knee pain	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-2db2syn	Ear Acupuncture for Quitting Smoking and Stress Relief: a clinical study	Not yet recruiting	Intervention	2026-03-12	<NULL>	<NULL>	8971	Auricular Acupuncture for Smoking Reduction/Cessation and Emotional Disorders in smokers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de Viçosa	<NULL>	<NULL>	<NULL>	Individuals who consume at least one cigarette daily at the time of data collection; present preserved cognitive function; exhibit moderate to high levels of anxiety, stress, and/or depression (Depression, Anxiety, and Stress Scale — DASS-21) and fatigue (Fatigue Assessment Scale — FAS), or poor sleep quality (Pittsburgh Sleep Quality Index — PSQI); are residents of the municipalities or members of the university community in Viçosa; have time availability for evaluations and treatment sessions; agree to be randomly allocated to the study groups; of both genders; and are aged 18 years or older	Ear piercings, except in the earlobe; history of allergy to metal or microporous tape; history of photosensitivity; presence of lesions, inflammation, deformity, or tattoos on the ear; history of skin cancer in the head and neck region; use of hearing aids; use of chemical peels (retinoic acid, retinol, Vitanol-A, tretinoin, isotretinoin) and/or Roaccutane® (Isotretinoin) within six months prior to the start of treatment, due to their photosensitizing properties; immunocompromised individuals (e.g., undergoing cancer treatment or using immunosuppressants); epilepsy; use of a cardiac pacemaker; pregnant or lactating women, or those planning to become pregnant during the study period; rejection of or fear of receiving the technique; and undergoing any other concomitant energetic therapy during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-9mfchtj	The right test, for the right patient, at the right time: using clinical and cerebrospinal fluid data to identify central nervous system infections	Not yet recruiting	Intervention	2026-03-15	<NULL>	<NULL>	8979	Prediction of infectious agents in the Biofire® FilmArray bioMérieux Meningitis/Encephalitis panel based on clinical syndrome and cerebrospinal fluid parameters: a diagnostic stewardship proposal	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-16	Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older, of any gender, who consent to participate in the study by signing an informed consent form will be included. To participate in the study, patients must present at least two of the following symptoms: fever, lethargy, altered level of consciousness, seizure, acute focal deficit, signs of meningeal irritation, or headache, all with onset within the last 30 days and, obligatorily, pleocytosis (at least 5 leukocytes in the cerebrospinal fluid) For the control group, patients aged 18 years or older, of any gender, who were hospitalized in the SCPA with clinical syndrome of central nervous system infection with confirmatory diagnosis by cerebrospinal fluid analysis in the last four years will be included. Only patients with at least 5 cells in the cerebrospinal fluid will be included	Patients who do not sign the informed consent form, patients with clinical manifestations lasting more than 30 days, patients under 18 years of age, as well as patients who have undergone neurosurgery in the last 30 days, will be excluded. In the control group, patients who have undergone neurosurgery in the 30 days prior to the onset of symptoms will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3ysvs5p	How technology aid dental students in detecting cavities: a practical study	Not yet recruiting	Intervention	2026-03-16	<NULL>	<NULL>	8983	Impact of artificial intelligence on the radiographic diagnostic ability of dental caries lesions by dentistry students: a randomized experimental trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-16	Universidade Federal de Juiz de Fora (UFJF)	<NULL>	<NULL>	<NULL>	Dental students from the Federal University of Juiz de Fora Governador Valadares campus, regardless of gender, social class, or religious belief; Extracted teeth permanent molars and premolars extracted for periodontal reasons, sound and/or with caries lesions in enamel and dentin	Students those who have not passed the course Dental Radiology I or Basic Dental Radiology; Extracted teeth with coronal restorations, endodontic access, coronal fractures, or partial or total coronal destruction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-108s9fg4	Strengthening the inspiratory muscles in obstructive sleep apnea	Not yet recruiting	Intervention	2026-03-17	<NULL>	<NULL>	8990	Inspiratory muscle training in individuals with obstructive sleep apnea	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-15	Escola de Educação Física da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Age over 18 years;men or women;diagnosis of obstructive sleep apnea;failure to adapt to continuous positive airway pressure therapy, low adherence to continuous positive airway pressure therapy (use for less than 4 hours on 70 percent of nights), or referral for conservative treatments (use of an intraoral appliance and orofacial myofunctional therapy);signing of the Informed Consent Form	Contraindications to inspiratory muscle training, such as: recent surgery (thoracic, abdominal, brain, ear, nose, and throat);pneumothorax;hemoptysis;pulmonary embolism;acute diarrhea or stress incontinence;dementia or any other condition in which the patient is unable to understand the test; patient discomfort; risk of infection;glaucoma or retinal detachment;abdominal hernia;recent acute myocardial infarction or unstable angina;severe arterial hypertension (systolic blood pressure greater than 200 millimeters of mercury and diastolic blood pressure greater than 120 millimeters of mercury);aortic aneurysm;neurological diseases;middle ear disorders;as well as inability to understand and/or perform the tests proposed for the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-4bj9kmt	Safety of performingbreathing exercises together with stationary cycling exercise in people whit heart failure	Not yet recruiting	Intervention	2026-03-17	<NULL>	<NULL>	8992	Safety of Inspiratory Muscle Training Concurrent with Aerobic Training in patients with heart failure	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Instituto Nacional de Cardiologia - INC	<NULL>	<NULL>	<NULL>	Patients of both sexes; diagnosis of heart failure with reduced ejection fraction lower than forty percent and functional class II or III according to the New York Heart Association (NYHA); participants of the cardiac rehabilitation program at the Instituto Nacional de Cardiologia with regular participation at least twice per week for at least three months	Inability to understand the commands required to perform inspiratory muscle training or aerobic exercise; physical limitation preventing the performance of inspiratory muscle training or aerobic exercise; presence of signs of infection at the time of recruitment or intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-6ww3q3j	Evaluation of different time frames for prosthesis placement following dental implantation	Not yet recruiting	Intervention	2026-03-18	<NULL>	<NULL>	8993	Early loading in Implant Dentistry involving single prostheses: randomized controlled clinical study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Faculdade de Odontologia do Campus de Araçatuba - UNESP	<NULL>	<NULL>	<NULL>	Patients of both genders; over 18 years of age; with good oral hygiene; no systemic contraindications for oral surgical therapy; with missing teeth or teeth indicated for extraction due to root fracture, caries, endodontic injury, or periodontal disease; who have an indication for rehabilitation with single implants; and who have adequate bone volume for implant placement, as assessed by Cone Beam Computed Tomography (bone availability for implants of at least 8 mm in length and 3.3 mm in diameter and without fenestrations in any wall that cannot be circumvented during surgery)	"Totally edentulous patients; patients who use medication that contraindicates the installation of implants or may alter osseointegration; patients with uncontrolled underlying diseases; patients who do not have adequate bone volume for the installation of implants; post-extraction cases that require gap closure with biomaterial and/or the use of a membrane; 
pregnant or lactating women; and heavy smokers (more than 2 packs of cigarettes per day)"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3zyhygn	Effects of intense training on memory and attention in people with High Blood Pressure and cognitive difficulties	Not yet recruiting	Intervention	2026-03-18	<NULL>	<NULL>	8995	Effect of high-intensity interval training on cognitive performance in hypertensive individuals with cognitive impairment: a blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-14	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Individuals of both sexes; age between forty-five and sixty-four years; diagnosis of early-onset systemic arterial hypertension before fifty-five years of age; undergoing treatment for systemic arterial hypertension; presence of mild to moderate cognitive impairment assessed by the Montreal Cognitive Assessment	Individuals with Systemic arterial hypertension stage two, defined by systolic blood pressure equal to or higher than one hundred and sixty millimeters of mercury and or diastolic blood pressure equal to or higher than one hundred millimeters of mercury; presence of severe cognitive impairment or diagnosis of dementia; speech impairment that limits or prevents communication; diagnosis of severe untreated mental disorder; history of severe cardiac diseases; abnormal twelve-lead electrocardiogram at rest or during physical exertion; contraindication to physical exercise indicated by a cardiologist; presence of secondary hypertension; evidence of target organ dysfunction, including kidneys and retina; grade two obesity; presence of severe cardiometabolic diseases; current participation in a structured physical training program; female participants with premature menopause, before forty years of age, or induced menopause	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-6n6wzsx	Study on the use of cannabidiol oil in the treatment of Major Depressive Disorder	Not yet recruiting	Intervention	2026-03-19	<NULL>	<NULL>	8996	Effects of full-spectrum cannabidiol oil on symptoms of Major Depressive Disorder: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Sociedade De Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Adult participants aged between eighteen and sixty nine years; residents of municipalities in the Greater Florianopolis region; previous diagnosis of Major Depressive Disorder confirmed according to the Diagnostic and Statistical Manual of Mental Disorders fifth edition text revision of the American Psychiatric Association; presence of a major depressive episode characterized by depressed mood and or loss of interest or pleasure for at least two weeks associated with additional symptoms compatible with the clinical diagnosis; current use of antidepressant medication for at least sixty days without satisfactory clinical response characterizing treatment resistant depression; voluntary agreement to participate in the study through signing the informed consent form	Use of cannabinoid substances natural or synthetic within thirty days prior to the beginning of the study; history of intolerance or adverse reaction to components of the Cannabis plant including confusion paranoia pruritus excessive somnolence vomiting diarrhea or seizures; women who are pregnant planning pregnancy or breastfeeding; presence of severe medical illness or clinical condition that may interfere with the evaluation of study outcomes; presence of decompensated psychiatric comorbidity including psychotic disorders severe personality disorders or active suicidal ideation; moderate or severe cognitive impairment that prevents adequate understanding of study assessment instrumentstivo moderado ou grave que impeça a adequada compreensão dos instrumentos de avaliação do estudo	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3xf65s5	Evaluation of the pharmacist’s follow-up in the management of chronic pain	Not yet recruiting	Intervention	2026-03-19	<NULL>	<NULL>	8998	Effect of pharmacotherapeutic follow-up in the management of chronic pain: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Patients diagnosed with osteoarthritis, gout, systemic lupus erythematosus, rheumatoid arthritis, and fibromyalgia; patients of both sexes; aged 18 years or older; currently using prescribed pharmacological treatment for these conditions for at least one month.	Patients with severe psychiatric disorders; cancer; pregnant women; patients without access to the WhatsApp® application; patients currently participating in other clinical trials evaluating the same outcomes of this study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-7gzhbqx	Potential effects of daily coffee intake on women with symptoms of Stress, Anxiety, and Depression	Not yet recruiting	Intervention	2026-03-19	<NULL>	<NULL>	9004	Potential effects of coffee consumption on symptoms of Stress, Anxiety, and Depression in Brazilian women: a translational mixed study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Saúde Pública da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Cisgender women; over the age of 18 will be included; with a Body Mass Index (BMI) between 18.5 and 29.9 kg/m²; with some level of stress, anxiety, or depression scored on the DASS-21 scale (between “mild” and “extremely severe”) referring to the week preceding the first eligibility interview; who have not been using psychoactive medications in the last eight weeks and who do not have an active diagnosis of psychiatric disorders	Women with a recent history (last six months) of diagnosed mental disorders and/or frequent use of psychiatric medications and stimulant supplements (sources of caffeine or similar) will be excluded; individuals with daily coffee consumption greater than 150 ml/day in the last 30 days; participants diagnosed with active gastric or duodenal ulcer, severe gastritis, symptomatic gastroesophageal reflux disease, or any other condition that prevents coffee consumption will also be excluded; pregnancy; lactation; menopause; simultaneous involvement in similar clinical studies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-7b39zbh	Use of artificial intelligence to assist dentists in diagnosing dental caries in radiographs in primary health care	Not yet recruiting	Intervention	2026-03-23	<NULL>	<NULL>	9006	Impact of using an artificial intelligence system in the radiographic diagnosis of caries lesions by primary healthcare dentists in Governador Valadares: a randomized experimental study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-25	Universidade Federal de Juiz de Fora Campus Governador Valadares	<NULL>	<NULL>	<NULL>	Dentists working in Primary Health Care in the municipality of Governador Valadares, Minas Gerais	Primary healthcare dentists who perform administrative functions; who have a specialization in radiology, or who are pursuing a specialization in radiology	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-65kd9hb	Effect of a intensive training in improving the use of the legs of individuals with incomplete spinal cord injury	Not yet recruiting	Intervention	2026-03-24	<NULL>	<NULL>	9008	Effect of Rehabilitation based on Activity Constraint-Induced Therapy for people with Spinal Cord Injury (ReACIT-SCI) in improving the use of the lower extremities of individuals with incomplete Spinal Cord Injury	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade do Estado de Santa Catarina	<NULL>	<NULL>	<NULL>	To be eligible, participants must: have an incomplete motor spinal cord injury of any neurological level and any etiology; have a chronic spinal cord injury, i.e., more than six months since the injury, with no upper time limit; be between 18 and 50 years old; be able to walk at least ten meters, with or without a walking aid, but without assistance from others; have a walking speed between 0.20 m/s and 1.00 m/s; be available to perform at least 75% of the in-person protocol and homework assignments; and have the possibility and ability to cancel other interventions aimed at improving mobility during the study period.	Insufficient level of understanding and communication to complete the Lower Extremity Motor Activity Log without assistance in less than 30 minutes, as therapists will administer the instrument daily during the intervention and need to complete it within this pre-established time; and some musculoskeletal, cardiorespiratory, or neurological condition not associated with spinal cord injury that has a direct effect on independence for mobility activities.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3vpbtn2	Gingival Graft Surgery and Donor Site Healing: A Randomized Clinical Trial	Not yet recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9010	Surgical techniques for gingival grafting and donor site regeneration strategies: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-30	Faculdade de Odontologia - Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Age between 18 and 60 years; both sexes; presence of isolated gingival recession ≥ 4 mm, classified as Miller Class I, II, or III or recession type 1 or 2 according to Cairo classification; systemically healthy patients with no contraindications for periodontal surgery; probing depth &lt; 3 mm at the involved sites; selected teeth free of restorations, caries, or non-carious cervical lesions	Smoking more than 10 cigarettes per day; uncontrolled diabetes mellitus; chronic or aggressive periodontitis; use of medications affecting bone metabolism; chronic upper respiratory tract infections; chronic use of anti-inflammatory drugs or antibiotics; bruxism; alcohol abuse or substance dependence; pregnancy or intention to become pregnant within one year; history of radiotherapy in the head and neck region; diseases affecting bone metabolism; extensive membrane rupture during the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-879qjjx	Influence of Dental Scaling on the adaptation of Complete Dentures	Not yet recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9013	Influence of prior Supragingival Scaling on tissue healing and adaptation of Immediate Complete Dentures	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Indication for extraction of all teeth due to periodontal disease in the maxilla or mandible; Age between 30 and 70 years; Need for total rehabilitation with a prosthesis; Sufficient health conditions to undergo surgical procedure (ASA I and ASA II); Sufficient cognitive capacity to understand the procedures to be performed and the Informed Consent Form	Smokers who consume more than 20 cigarettes daily; Those using medications that alter bone metabolism; Pregnant and breastfeeding women; History of head and neck radiotherapy; Insufficient cognitive function to understand the research protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-997wcch	Exploring Food Selectivity in Children with and without ASD and the Impact of a Parental Guidance Program	Not yet recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9014	Multicausal Investigation of Food Selectivity in children with and Without ASD and the Effects of a Parental Guidance Program	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Instituto Multidisciplinar em Saúde - Campus Anísio Teixeira	<NULL>	<NULL>	<NULL>	Children aged 3 to 10 years; with complaints of selective eating; with or without a diagnosis of ASD (Autism Spectrum Disorder); who present criteria for selective eating indicated by the Eating Behavior Assessment Scale; for inclusion in the group of children with ASD (Autism Spectrum Disorder), the child must have a professional diagnosis of ASD (Autism Spectrum Disorder)	Children under 3 or over 11 years of age; children with severe cognitive delay with a percentile lower than 10 on the intelligence test measured by the Columbia Mental Maturity Scale 3 or Raven&apos;s Colored Progressive Matrices; children with epilepsy; previously diagnosed genetic syndromes or with dysmorphisms indicating syndromes, by clinical evaluation and previous medical diagnosis; children with uncorrected vision and hearing problems, by clinical evaluation and previous medical diagnosis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-4h27jmk	AK001 Probiotic and Type 2 Diabetes: Efficacy and Safety Evaluation	Not yet recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9016	Safety and efficacy evaluation of AK001 probiotic supplementation in patients with Diabetes Mellitus 2	<NULL>	2-3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-30	Hospital Ana Nery	<NULL>	<NULL>	<NULL>	Individuals aged 30 to 65 years; of both sexes; with a confirmed diagnosis of Type 2 Diabetes Mellitus (T2DM); participants on stable metformin therapy (for at least 4 weeks at a stable dose); informed consent	Participants not receiving pharmacological treatment for glycemic control; participants who used probiotics and/or prebiotics in the month prior to the study inclusion visit; participants using antibiotics; presence of active autoimmune or infectious diseases; participants using other glucose-lowering agents beyond those permitted by the protocol (metformin); patients using hyperglycemic medications (e.g., glucocorticoids, thiazides, phenytoin, estrogens, beta-blockers, pentamidine, interferon, and others); chronic or acute kidney disease or any other medical condition, according to the investigator’s assessment; chronic pain from causes other than diabetic neuropathy; pregnancy or breastfeeding; allergy to any of the active ingredients or excipients of the product under study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-5t669rr	Effects of physical exercise on land and in water in adolescents with Congenital Heart Disease	Not yet recruiting	Observational	2026-03-26	<NULL>	<NULL>	9017	Effects of physical training on land and in water in adolescents with Congenital Heart Disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Universidade Estadual de Londrina - UEL	<NULL>	<NULL>	<NULL>	Adolescents between 12 and 20 years of age; of both sexes; diagnosed with Congenital Heart Disease; hemodynamically stable; who have undergone heart surgery; present some residual alteration and do not practice regular physical exercise; do not have a respiratory infection or hospitalization in the last three months; do not use a pacemaker	Moderate to severe arrhythmias; orthopedic or neurological conditions that prevent evaluations and proposed treatment; failure to complete all evaluations or withdrawing from the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-4ks3bmv	Study comparing Levobupivacaine and Ropivacaine in pain relief after foot and ankle surgeries	Not yet recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9019	Use of Levobupivacaine (S75-R25) 0.25% and Ropivacaine 0.25% in sciatic-popliteal nerve block for postoperative analgesia in foot and ankle surgeries: a randomized and double-blind study	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-29	Departamento de cirurgia da Faculdade de Medicina da Universidade Federal do Rio	<NULL>	<NULL>	<NULL>	Patients undergoing elective foot and ankle surgery;  both sexes; aged between 18 and 70 years; with ASA I and II physical status, according to the classification of the American Society of Anesthesiologists;  body mass index (BMI) &lt; 30	Patients with peripheral neuropathies; declared allergies to the medications used; coagulation disorders; popliteal fossa infection; pregnant women; those who have undergone medial malleolus surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-3r5k63t	Pea protein isolate: effects on blood amino acids after consumption	Not yet recruiting	Intervention	2026-03-27	<NULL>	<NULL>	9023	Effect of acute pea protein isolate consumption on plasma amino acid profile in healthy individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Healthy adult and elderly individuals (age ≥19 years). Only individuals who agree to participate in the study by signing the Informed consent form will be included	Individuals with any inflammatory process; pulmonary; cardiovascular; degenerative; neurological; or rheumatic diseases; cancer; diabetes mellitus; smokers; alcoholics; pregnant women; those using medication or any type of dietary supplement in the last 4 weeks prior to data collection or those with allergies or intolerance to the intervention will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-8b3wfmb	Comparison of the effects of three Physical Training protocols in asthmatic children	Not yet recruiting	Intervention	2026-03-27	<NULL>	<NULL>	9025	Comparison of the effects of three Physical Training protocols on clinical outcomes of children diagnosed with Asthma	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade Estadual de Londrina - UEL	<NULL>	<NULL>	<NULL>	Individuals aged between eight and 12 years; of both sexes; with a clinical diagnosis of asthma; who correctly use medication for control; do not practice physical exercise (except in school physical education); and who do not present cognitive, systemic, and motor alterations that could limit the performance of the study	Not completing all assessments; requiring hospitalization or abandoning the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-85nknzz	Virtual Reality and Music for pain relief during dressing changes in Vascular Ulcers	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9027	Virtual Reality and the use of Music in pain relief during dressing changes in Vascular Ulcers: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Pós Graduação em Enfermagem	<NULL>	<NULL>	<NULL>	Participants aged ≥ 18 years; of both sexes; with the presence of vascular ulcers; without neurological or cognitive conditions that may influence the results of the assessment scales; presenting pain intensity ≥ 4 on the assessment scales	Patients with diagnosed auditory and/or visual impairment or sensitivity; those who have scheduled or have undergone angioplasty of the affected limb during the data collection period; those on continuous use of analgesic medications or who have used such medications within 24 hours prior to data collection, which may interfere with pain during dressing changes; those presenting vestibular system disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-10kmkjj4	Lifestyle and health of adolescents from southern Bahia	Not yet recruiting	Observational	2026-03-30	<NULL>	<NULL>	9031	CRISCO-BA Study: health risk behaviors among adolescents in southern Bahia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade Católica de Brasília - UCB	<NULL>	<NULL>	<NULL>	"Students of both sexes; aged between 14 and 19 years; regularly enrolled in the integrated technical
high school programs at the  Federal Institute of Education, Science and Technology of Bahia, Ilhéus campus; presentation of the Informed Consent Form signed by parents or guardians for those under 18 years old, or by the adolescents themselves for those aged 18 or 19; presentation of the Assent Form signed by adolescents under 18 years old"	Physical and/or mental conditions that compromise safe participation, such as inability to understand or respond to questionnaires, severely reduced mobility; pregnant adolescents; absence on assessment days,resulting in incomplete data; and voluntary withdrawal	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-2phymmg	Study on tolerance and safety of different doses of Magic Mushroom Extract in healthy adults	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9034	Evaluation of the tolerability and safety of administering different doses of purified Psilocybin extract in healthy adults	<NULL>	1, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Instituto Alma Viva Limitada - ltda	<NULL>	<NULL>	<NULL>	Adults without comorbidities aged between 21 and 65 years from both gender	Participants  not eligible for the study are using of antidepressive drugs; have history of heart; liver; kidney disease; history of cancer or organ transplant; insulin dependent diabetes or uncontrolled diabetes; gastrointestinal disease that may interfere with the absorption of the substance orally; current or past history of psychiatric disorders as schizophrenia; psychotic disorder; bipolar disorder; personality disorder; first degree family history of psychiatric disorders; seizures or fainting; creatinine elevation; nicotine dependence that would prevent an individual from being nicotine-free for 7 to 10 hours during the dosing period; women who are pregnant or intending to become pregnant during the study or who are currently breastfeeding; chemical dependency or abuse of alcohol or illicit drugs in the last 12 months; platelets disorders;  clinically significant anemia and liver injury	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-10zwj9cs	Use of Non-invasive Brain Stimulation to aid physical recovery in street runners.	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9035	Transcranial Direct Current Stimulation as a Recovery Tool in Street Runners: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-05	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	<NULL>	<NULL>	<NULL>	Be between 18 and 45 years of age; Be a practicing street runner, having practiced this sport uninterruptedly for at least one year, with a training routine of at least 2 times a week; Have been able to run 5 km continuously in the time interval between 30 and 45 minutes at least 2 times a year; Not present severe cardiorespiratory and/or metabolic alterations; Not report musculoskeletal disorders in the lower limbs and spine in the last 6 months that have prevented the maintenance of the training routine; Not have used anti-inflammatory drugs, corticosteroids, analgesics or muscle relaxants in the 30 days preceding the start of the study; Not have used ergogenic resources, such as anabolic steroids, in the last 6 months preceding the start of data collection; Not have a neurological deficit that could compromise the follow-up and understanding of the interventions, as well as not using implanted metallic devices, and not be pregnant; Not having metal implants in the trunk and/or upper limbs	Failure to complete the 5km run within 45 minutes; Failure to correctly perform the assessment procedures; Use of anti-inflammatory drugs, corticosteroids, analgesics, or muscle relaxants during the data collection period; Undergoing other types of muscle recovery interventions during the research, such as cryotherapy or relaxing massage	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-4mbx874	Vitamin D levels, dietary intake and muscle strength in women with breast cancer: a comparative study	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9036	Vitamin D status, dietary intake, and muscle mass in women with Breast Cancer: a cross-sectional, longitudinal, and randomized clinical trial study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-09-01	Pró Reitoria de Pesquisa da Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Women aged 45 years or older; with breast cancer regardless of tumor histological subtype; clinical stage (I to IV), provided they are clinically stable and able to provide written informed consent (Informed Consent Form – ICF); who, at the end of Phase 2, present significant loss of lean body mass and development of vitamin D deficiency in the post-oncological treatment period	Presence of autoimmune diseases or neurological disorders that may hinder the interview; HIV infection; congenital muscular disorders; prolonged immobilization; significant muscle dysfunction; history of malignant neoplasms other than breast cancer; continuous use of vitamin D supplementation; contraindications to ultrasonography or other complementary examinations	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-7w6pmpg	Effect of a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9041	Effect of dietary monitoring based on a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal do Rio de Janeiro Campus Macaé	<NULL>	<NULL>	<NULL>	Adults: age between 18 and 59 years; both sexes; physically active (more than 150 minutes per week of physical activity). Older adults: age equal to or greater than 60 years; both sexes; eutrophic (body mass index between 22 and 27 kg/m²); physically active (more than 150 minutes per week of physical activity)	Adults: decompensated cardiovascular diseases; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; pregnancy; lactation; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements, multivitamins, or pharmacological agents. Older adults: diagnosis of severe decompensated cardiovascular disease; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements or pharmacological agents	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-2grxdz7	Effects of Aquatic Physiotherapy on the health and quality of life of elderly people in the community	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9042	Effects of Aquatic Physiotherapy on functionality, fear of falling, pain, well-being, and quality of life of community-dwelling elderly	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-11	Universidade Estadual de Goiás	<NULL>	<NULL>	<NULL>	People aged 60 or older; of both sexes; who are able to walk with or without the aid of walking aids	Older adults with severe cognitive impairment that precludes the use of assessment tools; older adults with contraindications to immersion in a therapeutic pool (uncontrolled blood pressure, severe heart failure, severe kidney disease, fever, recent surgery, uncontrolled epilepsy, low vital capacity, and deep vein thrombosis); or those who are clinically unstable at the time of assessment or intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-82tzn4t	Effect of a respiratory physiotherapy technique in infants undergoing cardiac surgery	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9045	Effects of the Thoracoabdominal Rebalancing Method in infants undergoing cardiac surgery: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Ciências da Saúde do Trairí	<NULL>	<NULL>	<NULL>	Participants aged between 0 and 24 months; of both sexes; between 12 and 72 hours after cardiac surgical procedures performed via median sternotomy or percutaneous route (catheterization); Infants must present clinical stability that allows respiratory physiotherapy; whether in room air or using oxygen therapy (low or high flow)	Infants with chronic lung disease that compromises respiratory function such as bronchopulmonary dysplasia; those using positive pressure ventilation; those with congenital deformities of the rib cage or shoulder girdle; those who develop diaphragmatic paralysis postoperativel; present hemodynamic instability defined as persistent changes in heart rate or blood pressure outside the limits for age and arrhythmias of difficult control	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-834k44k	Use of intravenous iron to treat anemia before gynecological surgery	Not yet recruiting	Intervention	2026-04-02	<NULL>	<NULL>	9055	Impact of Intravenous infusion of Ferric hydroxide sucrose in Anemic patients undergoing Gynecological surgeries: Randomized, controlled, double-blind study.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	The patients studied will be female, over 18 years of age, with an indication for elective hysterectomy with or without oophorectomy and/or annexectomy and myomectomy at HUCFF/UFRJ. Patients with anemia due to absolute or functional iron deficiency, Hg &lt; 12g/dl; ferritin &lt; 30 mcg/L or 30-300 mcg/L with transferrin saturation &lt; 20%	Individuals under 18 years of age. Patients who have received treatment with packed red blood cells before entering the protocol within the last 3 months. Patients undergoing urgent/emergency surgery. Patients with a formal contraindication to the use of intravenous iron, such as known hypersensitivity. Conditions that lead to secondary iron overload, such as: hereditary hemolytic anemias, myelodysplastic syndrome, Fanconi anemia. Anemias of other non-iron deficiency etiologies. Septic patients and pregnant women in the first trimester. Patients whose surgery was canceled or not performed. Patients participating in another clinical trial. Patients with dialysis-dependent renal failure.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-5fvwf5w	Evaluation of the use of toothpaste with Brazilian red propolis to relieve tooth sensitivity.	Not yet recruiting	Intervention	2026-04-05	<NULL>	<NULL>	9056	Evaluation of the potential for controlling dentin hypersensitivity with the use of red propolis toothpaste brazilian: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Instituto Leão Sampaio de ensino universitário	<NULL>	<NULL>	<NULL>	Age 18 or older; Presence of dentin hypersensitivity; Teeth (incisors, canines, premolars, or first molars) with a positive response to evaporative cold air stimulus on the Schiff Sensitivity Scale.	Pregnant women; Patients who underwent teeth whitening up to 8 weeks before the start of the study; Patients with a history of allergy to the components of the study material; Use of toothpaste or other type of desensitizing agent in the 30 days prior to the study; Teeth with mobility; Teeth with deep and defective restorations; Teeth with caries, fissures, fractures or any sign of pulpitis; Teeth with a history of trauma; Teeth used as abutments for removable partial dentures; History of allergy to propolis.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-6p53r5s	Program with digital support and personalized guidance to improve lifestyle habits of low-income older women	Not yet recruiting	Intervention	2026-04-06	<NULL>	<NULL>	9060	Effect of a hybrid social prescribing and digital support intervention on lifestyle determinants of low-income older women: a randomized mixed-methods clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos	<NULL>	<NULL>	<NULL>	Women aged 60 to 75 years; living in São Carlos-SP; who express interest in participating and meet the established criteria; especially age; place of residence; and individual income of up to 2 minimum wages	Women with significant cognitive impairment identified by the CS-10; which may compromise understanding of the instructions or autonomous completion of the assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-9w6hdgt	The Effect of Manual Therapy on Female Sexual Pain: A Multicenter, Randomized, Controlled, Blinded Clinical Trial	Not yet recruiting	Intervention	2026-04-07	<NULL>	<NULL>	9061	Female Sexual Pain	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade Federal do Delta do Parnaíba - UFDPar	<NULL>	<NULL>	<NULL>	Female volunteers experiencing pain during penetrative sexual activity (dyspareunia); aged between 18 and 40 years; able to understand and respond appropriately to the assessment instruments; have up-to-date gynecological examinations; be available to participate in all stages of the study; and sign the Informed Consent Form	Pregnant volunteers; volunteers in the postpartum period; diagnosed with serious neurological, rheumatological, oncological, or gynecological diseases; history of recent pelvic surgeries; presence of active genital infections; volunteers who have undergone pelvic physiotherapy treatment for sexual pain	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-10hp9qxg	Passagem study: lifestyle, sleep, health, nutrition, and bullying - monitoring in youth from Passagem, Rio Grande do Norte, Brazil	Not yet recruiting	Observational	2026-04-07	<NULL>	<NULL>	9062	PASSAGEM Study: physical ativity, sleep, health, diet, and bullying profile – Epidemiological monitoring among adolescents in Passagem, Rio Grande do Norte, Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Programa de Pós-graduação Stricto Sensu em Educação Física da Universidade Católica de Brasília - PPGEF-UCB	<NULL>	<NULL>	<NULL>	Adolescents of both sexes, aged 10 to 19 years, living in the municipality of Passagem, Rio Grande do Norte, Brazil, and registered or assisted by Primary Health Care Units will be eligible for inclusion in the study. Participation will require the presentation of a Written Informed Consent Form signed by parents or legal guardians for participants under 18 years of age, or by the participant when aged 18 or 19 years, as well as the Written Assent Form signed by adolescents younger than 18 years.	Adolescents presenting physical, cognitive, or mental conditions that prevent understanding the instructions or adequately completing the questionnaires will be excluded from the study, according to self-report by the adolescent and/or information provided by a legal guardian at the time of the invitation to participate. Adolescents who refuse to participate or withdraw at any stage of the data collection will also be excluded. Questionnaires with missing responses in the main study variables will be considered sample losses.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-6jt2f8b	Use of Low-Intensity Laser with Methylene Blue to treat Nipple Cracks during Breastfeeding	Not yet recruiting	Intervention	2026-04-07	<NULL>	<NULL>	9065	Effect of Low-Intensity Laser at the red wavelength associated with Methylene Blue for the treatment of Breast Fissures: a randomized controlled trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Postpartum women; aged between 18 and 40 years; who present with unilateral or bilateral nipple fissures, confirmed by a healthcare professional, for at least 1 week; with reported nipple pain greater than or equal to 5 on the Visual Analogue Scale (VAS); who are exclusively breastfeeding; those who agree to participate in the study must sign the Informed Consent Form, present in Appendix A	Postpartum women with active breast infection; participants undergoing any other topical treatment for the fissure, such as healing ointments, antibiotics, antifungals, or corticosteroid therapy; patients with a history of autoimmune skin diseases, atopic dermatitis in the breast area, or breast cancer; HIV/AIDS positive; participants with contraindications to photonic therapy; people with psychiatric disorders; and those who request to be withdrawn from the research.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-96dxm62	How Pilates can help with blood pressure and circulation in individuals with high blood pressure	Not yet recruiting	Intervention	2026-04-07	<NULL>	<NULL>	9066	Effects of the Pilates method on ambulatory blood pressure and central hemodynamics in individuals with arterial hypertension	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-15	Universidade Estadual de Maringá – Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Individuals of both sexes.Age equal to or greater than 30 years.Sedentary or irregularly active for at least six months (not meeting greater than or equal to 150 minutes per week of moderate physical activity or 75 minutes per week of vigorous physical activity).Diagnosis of systemic arterial hypertension (SAH), stage I or II, according to the Brazilian Hypertension Guidelines.Use of antihypertensive medications of any class.Medical clearance for physical exercise (medical statement/report).Agreement to sign the Informed Consent Form (ICF)	Cognitive impairment that compromises the ability to respond to the initial assessment questionnaire.Diagnosis of type 1 or type 2 diabetes mellitus.Relevant endocrine diseases.Current smoking.Orthopedic or neuromuscular conditions that prevent the performance of the exercises.Changes in medication during the study.Cardiovascular symptoms such as palpitations, exertional angina or other conditions that prevent continuation of the protocol.Pregnancy.Attendance lower than 75% of the scheduled sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-3fkv888	Effects of water-based therapy on balance, mobility, motor function and behavior in children with Autism: a randomized clinical trial	Not yet recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9071	Effects of adding water-based therapy to land-based psychomotor rehabilitation in children with Autism Spectrum Disorder on balance, mobility, motor function and behavior: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-04	Universidade Federal da Bahia	<NULL>	<NULL>	<NULL>	The study will include children aged 5 to 10 years; who have a diagnosis of Autism Spectrum Disorder made by a specialized medical professional; who are at support level 1 or level 2; who are regularly undergoing psychomotor rehabilitation; whose parents or legal guardians consent to participation in the study.	Individuals with fear of water immersion; those who exhibit aggressive behavior; those who are participating in other aquatic activities (such as swimming) at the time of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-10gcc5f8	Comparison of two membrane types for bone regeneration around immediate dental implants	Not yet recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9072	Evaluation of a bovine pericardium collagen membrane in guided bone regeneration around immediate implants: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Inclusion criteria comprise participants aged over 18 years classified as ASA I or ASA II according to the American Society of Anesthesiologists presenting teeth indicated for extraction in the aesthetic zone of the maxilla involving central incisor or lateral incisor or canine or first premolar or second premolar being a single unit. Participants must present transverse root position Class I or Class II or Class III according to Kan and Class I socket with intact buccal wall or Class II socket with up to one third of the buccal wall compromised in addition to buccal recessions of up to 2.0 millimeters and sufficient bone thickness and height for immediate implant placement with primary stability possessing natural teeth adjacent to the element to be extracted.	Patients classified above ASA II or heavy smokers defined as those consuming over 10 cigarettes per day or with a history of radiotherapy in the head and neck region or undergoing chemotherapy for treatment of malignant tumors or patients with uncontrolled diabetes defined as glycated hemoglobin above 7.0 millimoles per liter will be excluded. Also constituting exclusion criteria are the presence of pathological soft tissue alterations in the intervention region such as leukoplakia or lichen planus or erythroplakia and extensive periapical bone pathological alterations that prevent implant placement as well as localized periodontitis in the intervention region or Stage IV Periodontal Disease without occlusal stability or Class IV sockets according to Kan.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-5p9x6hb	Integrated care for anxiety and well-being in adults and elderly: mixed methods study with guided spiritual visualization and aromatherapy with lavender essential oil	Not yet recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9075	Integrative nursing in the care of anxiety and well-being of adults and older adults: study of mixed methods with guided imagery of spiritual approach and aromatherapy with Lavandula angustifolia essential oil	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Departamento de Enfermagem	<NULL>	<NULL>	<NULL>	Participants of either sex; age ≥ 19 years; with a history of mild to moderate anxiety whether diagnosed or self-reported; with no history of psychiatric disorders and no allergy to lavender or other scents	Presence of severe anxiety; olfactory disorders or hearing impairments that may prevent the patient from hearing the audio used during the image guided procedure properly	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-328f225	Use of Light Therapy as support for Gum Treatment in patients with Periodontitis	Not yet recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9079	Effect of Photodynamic Therapy as an adjunct to Non-Surgical Periodontal Treatment in patients with Periodontitis randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Facultad de odontología Universidad Central de Venezu	<NULL>	<NULL>	<NULL>	individuals of both sexes; age 18 years or older; diagnosis of stage III or IV periodontitis; no periodontal treatment within the last three months; no antibiotic therapy within the last three months	smoking; presence of uncontrolled systemic diseases; uncontrolled diabetes mellitus; pregnancy or lactation; malignant diseases; oncologic treatment; use of orthodontic appliances; allergy to methylene blue; age over 60 years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-79zrm8y	Effect of an educational program on antibiotic dispensing quality in community pharmacies: a multicenter study	Not yet recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9080	Impact of an Educational Program on the quality of antimicrobial dispensing in community pharmacies: a multicenter study	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Pharmacists working in private community pharmacy chains; who perform medication dispensing; aged over 21 years; male or female; holding a higher education degree in Pharmacy; and who agree to participate in the study voluntarily	Pharmacists who are unavailable to participate in the educational program; who may compromise the anonymity of the simulated patient; whose data cannot be collected after the intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-88q3q9j	Temporary implants for restoring lost teeth in children and adolescents after accidents	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9091	Temporary Implants in Anterior Rehabilitation of Children and Adolescents with Traumatic Tooth Loss	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Faculdade de Odontologia - Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients in the growth phase aged between 6 and 17 years; traumatized permanent anterior dentition; single anterior edentulism resulting from tooth avulsion or root resorption following replantation; absence of the tooth in the dental arch or current indication for provisional rehabilitation in the anterior region; healed soft tissues without clinical signs of acute infection; systemic health condition compatible with the proposed treatment; signed informed consent from the patient and legal guardians when applicable; willingness to comply with the full clinical follow-up protocol	Technical inability to maintain the provisional restoration out of functional occlusion; persistently poor oral hygiene or presence of moderate to severe gingivitis, periodontitis, or active infection at the site; smoking in adolescents; uncontrolled systemic diseases or use of medications that interfere with bone metabolism including chronic systemic corticosteroids, immunosuppressants, or bisphosphonates; refusal or inability to attend scheduled follow-up visits and undergo serial clinical and radiographic assessments over the 24-month period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-67m72sm	Effect of Magnetic Stimulation on Body Movement	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9092	Influence of Transcranial Magnetic Stimulation on motor evoked potentials	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-05	Universidade Federal de Alfenas	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 30 and 75 years; diagnosis of left ischemic stroke confirmed by computed tomography or magnetic resonance imaging; between 3 weeks and 1 year post stroke; right upper limb motor preference assessed by the Edinburgh Handedness Inventory translated and validated into Portuguese with inclusion of only right handed participants with right hemiparesis and preserved right handgrip function; minimum score of 27 points in the upper limb domain of the Fugl Meyer scale	Left sided motor preference assessed by the Edinburgh Handedness Inventory; orthopedic disorders; contraindications to repetitive transcranial magnetic stimulation including personal or first degree family history of epilepsy or seizures presence of metallic implants or active electronic devices in the head or neck presence of cardiac pacemaker or implanted defibrillator; inability to understand written and spoken Portuguese; pain during task execution; difficulty performing handgrip or index finger flexion movements; failure to reach at least 70 percent of maximal voluntary isometric contraction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-8zk47ww	Effect of collagen on muscle mass gain and strength in women with lipedema	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9095	Effect of supplementation with bioactive collagen peptides on lean mass gain and muscle strength in women with lipedema	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Abralipedema Pro Organização de Ensino Ltda	<NULL>	<NULL>	<NULL>	Women aged greater than or equal to 25 years and less than or equal to 45 years; clinical diagnosis of lipedema stages II to III; regular menstrual cycles or medication-induced amenorrhea; regular physical activity practice greater than or equal to 150 minutes per week; body weight stability with variation less than or equal to 3 percent in the last 3 months; agreement to maintain dietary habits and physical activity level during the study; discontinuation of supplements that may interfere with muscle mass, such as protein supplements, creatine and branched-chain amino acids (BCAA); signing of the Informed Consent Form (ICF).	Pregnant women; breastfeeding women; women planning pregnancy; presence of symptoms or diagnosis of menopause; uncontrolled chronic diseases; relevant musculoskeletal or neuromuscular disorders; fractures within the last 12 months; performance of aesthetic surgeries or liposuction within the last 6 months; recent use of protein supplements or substances that affect body composition; use of medications that significantly interfere with body composition; allergy to supplement components; presence of eating disorders; severe psychiatric disorders; participation in another clinical study within the last 12 months; any condition that prevents adherence to the protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-4djzt48	Impact of different physical activities on the health of women in the climacteric	Not yet recruiting	Intervention	2026-04-14	<NULL>	<NULL>	9097	Impact of different types of non-pharmacological interventions on the health of climacteric women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Centro Universitário UNIFIPMOC	<NULL>	<NULL>	<NULL>	Women in the climacteric stage aged between 45 and 70 years; receiving care from primary health care services in Montes Claros, Minas Gerais, Brazil; medically cleared to participate in physical activity through a medical certificate.	Physical or cognitive limitations that prevent participation in the proposed interventions; uncontrolled cardiovascular, respiratory, or musculoskeletal diseases that preclude exercise practice; participation in another structured physical exercise program during the study period; failure to complete baseline assessments.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-10v32pjc	The  effect of exercise and Physcial Therapy on heart rate in people with Spinal Cord Injury: a randomized clinical trials	Not yet recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9102	Heart rate variability patterns in individuals with Spinal Cord Injury undergoing a physical exerecise program and Physical Therapy:  randomized clínical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-15	Departamento de Fisioterapia da Universidade Estadual de Londrina	<NULL>	<NULL>	<NULL>	Volunteers of both sexes; aged 18 to 50 years; with a medical diagnosis of spinal cord injury with neurological levels ranging from the second thoracic segment to the first lumbar segment; with spinal cord injuries classified as complete like paraplegia and anesthesia and incomplete  like paraplegia and hypoesthesia; with an injury dating back more than 6 months; who do not regularly engage in physical activity or physical therapy	Individuals with other associated neurological diseases like the traumatic brain injury and peripheral nerve injury; heart disease; lung disease, suspected LME; and those who are unable to complete the tests for any reason including withdrawal, hospitalization, infections, and skin, osteoarticular, vascular, or respiratory complications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-2n84wsc	Effect of beetroot juice on the performance of women who practice cycling	Not yet recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9103	Effects of beetroot juice concentrate supplementation on the performance of female cyclists in an endurance trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-27	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women aged between 18 and 60 years; cycling practitioners with a minimum of one year experience; training frequency of at least two to three times per week; signing of the Informed Consent Form	Presence of intellectual or physical disabilities; clinical, neuromotor, neurological, psychiatric or cognitive impairments; recent injury or in recovery period; musculoskeletal injuries; use of androgenic anabolic steroids; smoking; patients with known chronic degenerative pathologies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-7bwk89s	Effects of supervised physical exercise on functional capacity and quality of life of patients with Fontan-type circulation	Not yet recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9106	Effects of supervised cardiopulmonary rehabilitation on the functional capacity of pacientes with Fontan-type circulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Instituto Dante Pazzanese de Cardiologia	<NULL>	<NULL>	<NULL>	Age equal to or greater than 8 years; having undergone Fontan surgery at least 6 months ago; clinically stable, with the ability to perform physical exercises and functional tests	Formal contraindication to physical exercise or cardiopulmonary testing; diagnosis of severe arrhythmias, decompensated heart failure, severe lung diseases, significant motor limitations, or resting peripheral oxygen saturation below 80%	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-3x4nbvh	Sensory integration in Virtual Reality for children with Autism	Not yet recruiting	Intervention	2026-04-17	<NULL>	<NULL>	9115	Sensory integration in Immersive Virtual Reality: randomized clinical trial with children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2027-04-01	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Be between 8 and 12 years of age; have prior experience with computer games; have a diagnosis of Autism Spectrum Disorder confirmed by presentation of the Identification Card for Persons with Autism Spectrum Disorder; demonstrate verbal communication skills or communication through Augmentative and Alternative Communication; present sensory difficulties as indicated by the Sensory Processing Measure; demonstrate the ability to complete at least 9 items of the Evaluation in Ayres Sensory Integration	Have a diagnosis of other neurological disorders such as cerebral palsy or Down syndrome; present comorbidities that preclude participation in Immersive Virtual Reality as reported by caregivers; present sensory deficits that prevent the use of Immersive Virtual Reality equipment; report malaise, nausea, or recurrent episodes of vomiting	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-53kxb7j	Using light to treat tooth stains: controlled and randomized trial	Not yet recruiting	Intervention	2026-04-19	<NULL>	<NULL>	9120	Transillumination prior to resin infiltration for masking hypomineralized lesions: a randomized controlled clinical trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade Federal do Piauí	<NULL>	<NULL>	<NULL>	Children and adolescents exhibiting well defined; creamy-white or yellow opacities in an incisor without post eruptive structural loss	Participants were those using fixed orthodontic appliances on their incisors; incisors with composite resin restorations; carious lesions on their central incisors; other enamel developmental defects such as dental fluorosis; hypoplasia, amelogenesis and dentinogenesis imperfecta, and participants with non cooperative behavior	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9py9sc7	Effect of virtual reality and walking assistance in gait rehabilitation in Parkinson&apos;s patients	Not yet recruiting	Intervention	2026-04-20	<NULL>	<NULL>	9121	Impact of virtual reality and and partial body weight support  on gait rehabilitation in patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	The inclusion criteria will include participants of both sexes, with functional walking deficits; but who are able to walk without an assistive device for at least 10 meters;  weigh more than 30 kg; are able to respond to and understand commands; are in stages 1–3 of the Hoehn &amp; Yahr scale; have medical supervision; and are available for the duration required by the study	Exclusion criteria will include patients with significant cognitive impairment; severe motor impairments such as disabling dyskinesias; extreme rigidity; or severe postural instability; as well as those who require the continuous use of walking aids. In addition, individuals with acute systemic or neurological comorbidities; severe joint deformities; uncontrolled epilepsy; sensitivity to visual stimulation, or uncorrected visual and vestibular impairments that hinder the safe execution of the protocol will not be included	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9px8h63	Acupuncture for breast cancer pain: study with women	Not yet recruiting	Intervention	2026-04-20	<NULL>	<NULL>	9123	Effects of Auricular Acupuncture on the treatment of cancer pain in women with Breast Cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; be a woman; be undergoing treatment for breast cancer, regardless of the type of oncological therapy; have undergone surgery for the disease prior to the study, at least three months and at most 10 years earlier; report pain that began after surgery, with an intensity greater than or equal to 4 points on the Numeric Rating Scale (NRS)	Present metastasis; have cognitive impairment that precludes responding to the study instruments; be using high doses of anticoagulants; have undergone auricular acupuncture treatment for cancer-related pain within the three months prior to the study; present ear piercings near the auricular points to be used in the study; report a history of allergy to needles, seeds, or microporous tape; present lesions, inflammation, deformity, or tattoos on the ear; or use a hearing aid	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-89495pk	Effect of anti-inflammatory injection on the success of anesthesia in lower molar teeth in cases of toothache	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9125	Efficacy of submucosal Dexamethasone infiltration in anesthetic success in inferior alveolar nerve block, in cases of Symptomatic Irreversible Pulpitis in mandibular molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-10	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Individuals over 18 years of age of both sexes diagnosed with symptomatic irreversible pulpitis in the first or second mandibular molars; reporting moderate to intense pain at the time of initial assessment; with a score of 4 or higher on the Numerical Pain Scale (NPS); classified as healthy and immunocompetent according to the criteria of the American Society of Anesthesiologists (ASA); adapted for the dental clinic; who demonstrate full comprehension of the pain assessment scales and the informed consent form	Patients who after the start of the procedure decide or need to abandon treatment before the completion of the dental procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-3kdnvsg	Management of breastfeeding in the incidence of hospitalization for hyperbilirubinemia in newborns.	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9126	Effectiveness of breastfeeding management on weight gain and bilirubin levels in newborns: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal do Piauí	<NULL>	<NULL>	<NULL>	Newborns of both sexes; aged between 24 and 48 hours of life; with gestational age between 37 weeks and 41 weeks and 6 days; and birth weight between 2,500 g and 3,999 g.	Newborns with congenital malformations perceptible on physical examination or reported by the mother; jaundice in the first 24 hours of life; ABO and/or Rh incompatibility; family history of a sibling treated with phototherapy for neonatal jaundice; Asian descent; or the presence of cephalohematoma or ecchymoses, since these conditions constitute risk factors for significant hyperbilirubinemia in neonates with a gestational age greater than 35 weeks.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2g8tk6t	Effects of resveratrol on heart health after exercise in menopausal women	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9129	Effects of resveratrol supplementation on cardiovascular Recovery and post-exercise muscle function in menopausal women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Fundaçao Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Women aged 40 to 60 years with body index mass of 18.5 to 34.9 kilograms per square meter and low density lipoprotein high or equal to 130 milligrams per deciliter will participate in the study; All participants must be postmenopausal at the start of the intervention; Age at menopause will be categorized as under 45 years early menopause 45 to 49 years relatively early menopause 50 to 51 years reference or 51 years or older relatively late menopause; They must have had no menses in the last year; Able to comply with the study protocols; They must not have any pathologies that could affect their nutritional status; During participation in this clinical trial all women will receive special attention to ensure their well-being comfort and safety; The study was ethically designed to minimize any physical risks associated with the data collection steps	Self-reported use of anticoagulant agents including nonsteroidal anti-inflammatory drugs oral cortisone or other immunosuppressive agents; Presence of neoplasia or immunological disease; Restricted or reduced physical activity due to chronic health conditions; Blood pressure high or equal to 140/90 millimeters of mercury; Kidney or liver disease; Heart disease including cardiovascular events or stroke; Cancer diagnosis in the last five years; Inability to comply with study requirements and procedures; Inability to perform treadmill test due to limitations such as orthopedic problems or moderate to severe aortic stenosis; History of myocardial infarction in the last three months or angina under treatment; Inability to perform handgrip test due to limitations such as pain or deformity	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-7bwtfry	Pilates mat exercises and supplementation as strategies to promote health in women 50+	Not yet recruiting	Intervention	2026-04-24	<NULL>	<NULL>	9135	Mat pilates and supplementation as strategy for promoting well-being in women aged 50+: a randomized placebo-controlled clinical trial	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade de Passo Fundo	<NULL>	<NULL>	<NULL>	To participate voluntarily in the study, participants must: understand the study procedures and agree to participate voluntarily and sign the Informed Consent Form; be 50 years of age or older; be menopausal (12 months or more of amenorrhea); be willing to use the new supplementation with annatto (Bixa orellana L), yerba mate (Ilex paraguariensis A. ST.-Hil.) and hops (Humulus lupulus L.) throughout the study; not be using hormone replacement therapy; and have a skin phototype between I and IV on the Fitzpatrick scale (MSD Manuals Professional Edition, [n.d.]), since the equipment used for cutaneous autofluorescence analysis has adequate sensitivity only for these phototypes, ensuring the reliability of the measurements	Uncontrolled systemic arterial hypertension, having had or currently having cancer, autoimmune diseases such as lupus, inflammatory diseases such as Crohn&apos;s disease, no self-reported serious illness, severely ill individuals, and withdrawal of consent; surgery requiring hospitalization within 3 months of the first study visit after screening; absence of health conditions that prevent compliance with study requirements as judged by the investigator based on medical history; severe trauma or surgical event within 3 months of screening; individuals using anticoagulants, since hops have an antiplatelet effect; reluctance or inability to comply with experimental procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-7h3wfcg	Impact of Breathing Training on Cardiac Patients&apos; Recovery: Randomized Research Study	Not yet recruiting	Intervention	2026-04-24	<NULL>	<NULL>	9136	Effects of Inspiratory Muscle Strength and Endurance Training on voice and cardiorespiratory function in individuals undergoing Cardiac Surgery: A Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Volunteers aged 40 or older; with a medical prescription for physiotherapy; candidates for valve replacement (VT), coronary artery bypass grafting (CABG), or combined surgery (CABG + VT); clinically stable	Individuals with unstable angina; severe valvular heart disease; head and/or spinal trauma; severe trunk injury; neurological disorders; vocal cord paralysis and laryngeal disorders assessed by an otolaryngologist in the preoperative period; self-reported gastroesophageal reflux (GERD) and/or hearing loss; untreated or exacerbated psychiatric disorders; difficulty responding to questionnaires adequately due to allo- or autopsychological factors; acute kidney injury; peripheral neuropathy; musculoskeletal disease; morbid obesity (Body mass index greater than 40 kg/m²); infectious disease; cancer patients (post-chemotherapy); who have not undergone surgery; who have not had at least five days of preoperative intervention; participants who developed surgical wound infection, stroke and/or myocardial infarction during surgery; worsening of the hospitalization condition	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-5jbrjcb	Use of virtual nursing rounds at night to prevent falls in hospitalized older patients	Not yet recruiting	Intervention	2026-04-25	<NULL>	<NULL>	9138	Virtual hourly intentional nursing rounds in hospitalized elderly patients during the nighttime: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	<NULL>	<NULL>	<NULL>	Hospitalized patients aged between 65 and 100 years; patients admitted to geriatric or medical-surgical units, with or without a caregiver; patients who agree to participate and sign the informed consent form	Patients who refuse to participate; patients previously selected for continuous video monitoring according to institutional criteria; patients classified as bedridden or restricted to bed	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-735p6cp	Evaluation of an App for Prescribing Home-Based Exercises for Common Musculoskeletal Conditions	Not yet recruiting	Intervention	2026-04-27	<NULL>	<NULL>	9142	Feasibility and Effectiveness of a Digital Tool for Prescribing Home-Based Physical Exercises for Prevalent Musculoskeletal Conditions	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Individuals with shoulder impingement syndrome; or nonspecific low back pain; or greater trochanteric pain syndrome; or knee osteoarthritis; or patellofemoral pain syndrome; or Achilles tendinopathy; under regular follow-up at Hospital de Clínicas – Unicamp; who are not undergoing physiotherapy; and who have no plans to start physiotherapy in the next three months	Volunteers who do not have a smartphone; incompatible smartphone; a prosthesis that prevents performing the exercises; decompensated psychiatric disorder; under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-296z9hd	Effect of 12 weeks of a training program with muscle strength exercises in open and closed kinetic chain on postural control performance, muscle activation and lower limb muscle power	Not yet recruiting	Intervention	2026-04-28	<NULL>	<NULL>	9146	Effect of a 12 week training program with muscle strength exercises in open and closed kinetic chain on postural control performance, muscle activation and lower limb muscle power: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Healthy older adults; Age equal to or greater than 60 years; Residents of João Neiva, Espírito Santo, Brazil;Young adults; Age between 18 and 35 years; Healthy	Neurological diseases; Dependent gait; Altered cognitive functions; Depressive symptoms; Auditory or vestibular impairment; Inability to perform strength training	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-75s78rj	Learning safe surgery with virtual reality: how undergrad students retain knowledge better	Not yet recruiting	Intervention	2026-04-28	<NULL>	<NULL>	9148	Training in safe surgery using virtual reality for knowledge retention among undergraduate students at a public university	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Fundação Universidade Federal de São João Del Rei - C. C. Oeste Dona Lindu	<NULL>	<NULL>	<NULL>	Nursing students; both male and female; aged at least 18 years; who have completed courses covering surgical care content	Students on leave from their undergraduate studies for any reason at the time of data collection will be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-5dknb4r	Use of genetics and artificial intelligence to personalize medical cannabis treatment for anxiety and depression	Not yet recruiting	Observational	2026-04-29	<NULL>	<NULL>	9155	Medicinal cannabis, personalized intelligence: artificial intelligence and pharmacogenomics in the treatment of anxiety and depression in the Brazilian public health system	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Adults aged 18 or older; of both sexes; residing in the state of Santa Catarina; with a medical diagnosis of anxiety disorder and/or depressive disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5); regularly using full-spectrum medicinal cannabis oil prescribed by their attending physician; cognitively capable of understanding the study procedures and providing free and informed consent	Individuals with medical contraindications to the use of medicinal cannabis; unable to provide the necessary saliva sample; lacking the minimum clinical data required for analysis; or who refuse to participate in the research or sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-10vzd55h	Use of a new synthetic membrane in surgery for ocular surface reconstruction	Not yet recruiting	Intervention	2026-04-30	<NULL>	<NULL>	9158	Polydioxanone membrane for guided conjunctival tissue reconstruction: an experimental model	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Banco de Olhos de Sorocaba	<NULL>	<NULL>	<NULL>	Participants of both genders; age 18 years or older; presence of one of the following ocular surface tumors: conjunctival nevus, conjunctival melanoma, ocular surface squamous neoplasia, or primary acquired melanosis of the conjunctiva; best corrected visual acuity better than 20/40 in the contralateral eye; provision of written informed consent	Presence of corneal disease in the affected eye, including previous opacities, scars, dystrophies, or infections; systemic diseases with ocular involvement; pregnancy; previous ocular surface surgery in the affected eye; allergy to any medication used in the postoperative period; glaucoma or ocular hypertension, eyelid disease, or lacrimal disease in the affected eye; any ophthalmologic condition or disease in the contralateral eye other than low refractive error; presence of a small lesion allowing primary conjunctival closure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-10jc56n7	Study on the cost-benefit of a barbatimão-based product in controlling microorganisms and promoting wound healing.	Not yet recruiting	Intervention	2026-04-30	<NULL>	<NULL>	9160	Cost-effectiveness of an active ingredient based on Stryphnodendron barbatiman on microbial load and tissue repair process in wounds: Translational research	<NULL>	3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade Federal Fluminense	<NULL>	<NULL>	<NULL>	Be over 18 years of age, regardless of gender; have a chronic wound larger than 2 cm² and smaller than 100 cm²; have a wound that has been present for more than 12 weeks; have a wound without signs of infection (PEDIS 1 or NERDS/STONES negative); and be available to attend the outpatient clinic weekly.	Pregnant and breastfeeding women; Undergoing immunosuppressive and/or antimicrobial therapies; Suspected or confirmed oncological disease associated with the wound; Suspected or confirmed wound infection; People with visual and/or hearing impairments or who do not have full autonomy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-5wz8jp7	Effects of a silver-based mouthwash on the treatment of gum inflammation caused by dental plaque	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9169	Effects of a Silver Nanoparticle-Based Mouthwash in the Treatment of Biofilm-Induced Generalized Gingivitis	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Evangelica de Goiás	<NULL>	<NULL>	<NULL>	Adult individuals (≥18 years) of both sexes will be included; systemically healthy (absence of diagnosed systemic diseases that may interfere with the inflammatory response or periodontal healing); with the presence of biofilm-induced gingivitis, characterized by: bleeding on probing (BOP) in &gt;30% of the evaluated sites, probing depth ≤3 mm in all sites, absence of clinical attachment loss and absence of radiographic bone loss; presence of at least 20 fully erupted permanent teeth (excluding third molars); capacity and willingness to understand and sign the Informed Consent Form and adhere to the study protocol.	The following will be excluded: pregnant or breastfeeding women; individuals with systemic diseases that may interfere with periodontal condition or response to treatment (e.g., uncontrolled diabetes mellitus, immunosuppressive diseases); use of antibiotics, anti-inflammatory drugs, or immunosuppressants in the last 3 months; previous history or current presence of periodontitis (according to clinical and radiographic criteria); presence of gingival diseases not induced by biofilm (e.g., drug-induced gingivitis, mucocutaneous diseases); smokers or former smokers who quit less than 12 months ago; presence of extensive prostheses or conditions that hinder periodontal evaluation; periodontal therapy performed in the last 6 months; need for antibiotic prophylaxis for routine dental procedures; known allergy to any components of the formulations used in the study; individuals who are legally incapacitated or have limitations that prevent compliance with the protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-9wyb7ht	Use of Botulinum Toxin during hemorrhoidectomy surgery in an attempt to reduce postoperative pain and accelerate healing	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9172	Analysis of pain and wound healing in the treatment of hemorrhoidal disease with intraoperative botulinum toxin in the postoperative period of open hemorrhoidectomy: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Fundacao do ABC	<NULL>	<NULL>	<NULL>	Both sexes; hospitalized for elective hemorrhoidectomy; grade III or IV hemorrhoidal disease with or without anal skin tags; 18 years of age or older; in agreement and sign the informed consent form	History of egg allergy; presence of uremia or impaired renal function; use of antibiotics; use of steroidal anti-inflammatory drugs; use of magnesium sulfate-based calcium channel blockers; use of anticoagulants; preoperative fecal incontinence; presence of other diseases such as anorectal fissure or fistula associated with hemorrhoidal disease; clinical suspicion of neoplastic lesion of the anal canal or associated with hemorrhoidal disease; pregnant or breastfeeding women; performance of another surgical technique for the treatment of hemorrhoidal disease.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-3sfstb5	Physiological Responses to Sprint Interval Exercise Under Hypoxic Conditions in Trained Cyclists	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9173	Effects of Inter-effort Recovery Intermittent Hypoxia on Nitrate and Nitrite Bioavailability, Endothelial Function, Muscle Oxygenation, and Exercise Tolerance during Sprint Interval Training	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Male individuals; aged between 18 and 45 years; cyclists; born and residing at low altitude locations	History of metabolic or cardiovascular diseases; recent diagnosis of anemia; recent exposure to normobaric or hypobaric hypoxia; recent muscular injury; use of vasodilating foods or supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-9ctfqpt	Influence of a Flexible Exoskeleton on the ability to perceive objects by touch in children with cerebral palsy	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9175	Influence of a Tensegrity-Based Exoskeleton on haptic perception in children with Cerebral Palsy (CP)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Programa Pós-Graduação em Ciências da Reabilitação (PPGCR) da Universidade Federal de Minas Gerais (UFMG)	<NULL>	<NULL>	<NULL>	Children aged between eight and fourteen years and eleven months; of both sexes; with a diagnosis of cerebral palsy; classified at levels I or II of the Gross Motor Function Classification System (GMFCS), which is a system for classifying gross motor function; classified at levels I or II of the Manual Ability Classification System (MACS), which is a system for classifying manual ability; who have not undergone orthopedic surgery in the last six months; who are able to understand and follow verbal instructions	Children who are unable to complete the proposed assessment or perform the requested tasks during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-4k8dp49	Exercise Program for people with Chagas Disease affecting the heart: a study with randomly assigned groups	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9176	Evaluation of the effects of Aerobic Physical Training in Chronic Chagas Cardiomyopathy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-10	Escola de Educação Física, Fisioterapia e Terapia Ocupacional (EEFFTO) da Universidade Federal de Minas Gerais (UFMG)	<NULL>	<NULL>	<NULL>	Adults (aged 18 years or older); both sexes; confirmed Chagas disease based on two distinct serological tests (e.g., indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA), or hemagglutination); evidence of myocardial involvement defined by segmental or global systolic dysfunction on echocardiography or by electrocardiographic abnormalities suggestive of Chagas cardiomyopathy; left ventricular ejection fraction (LVEF) higher than 40%; New York Heart Association (NYHA) functional class I or II; recruitment at the Chagas disease outpatient clinic at the Hospital das Clínicas of the Federal University of Minas Gerais (UFMG) and at participating centers of the Federal University of Triângulo Mineiro (UFTM) and the Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM)	Patients presenting with another etiology for myocardial dysfunction, such as alcoholism, previous myocardial infarction, known coronary artery disease, use of cardiotoxic agents or illicit drugs, peripartum cardiomyopathy, primary valvular heart disease, and pericardial disease, will be excluded. Patients with comorbidities that impair functional capacity, such as Chronic obstructive pulmonary disease (COPD) severe, severe liver disease, collagen vascular disease, and untreated thyroid dysfunction, will also be excluded. Coronary artery disease (CAD) must be ruled out by cardiac catheterization in patients who present ischemic perfusion defects on myocardial perfusion scintigraphy and have three or more risk factors for atherosclerotic coronary artery disease. Finally, individuals presenting physical limitations (orthopedic or neurological) to aerobic exercise on a treadmill and/or walking, or any contraindication to moderate-intensity aerobic physical activity, will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-4r22qwn	Study of the Drug Trimetazidine in the Treatment of People with Stroke	Not yet recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9178	Use of Trimetazidine for The Treatment of Patient with Ischemic Stroke Randomized Double Blind Clinical Trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-07	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; of both sexes; with a diagnosis of ischemic stroke confirmed clinically or by neuroimaging; with symptom onset within 24 hours; who agree to participate by signing the informed consent form by the participant or legal representative	Participants with a diagnosis of hemorrhagic stroke; with more than 24 hours since symptom onset; with a diagnosis of Parkinson’s disease; with neoplasms; with diagnosis of encephalic infection; pregnant women; with a history of allergy to any component of the medications used in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-10vf2byw	Effect of Gum Treatment on saliva and gingival fluid proteins in people with type 2 Diabetes	Not yet recruiting	Intervention	2026-05-09	<NULL>	<NULL>	9186	Effect of Periodontal Treatment on the proteomic profile of saliva and gingival fluid in type 2 diabetic patients with Periodontitis	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-02	Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	individuals over 30 years of age; with stage III-IV periodontitis; who provide saliva samples of at least 1 ml; who provide complete information on health-related issues; who have at least 15 teeth in their mouth; a minimum of 4 functional teeth and at least 3 adjacent teeth with interproximal papilla in at least one posterior quadrant of the maxilla; and who are able to read, understand, and sign an informed consent form.  For participants with diabetes mellitus, the inclusion criterion will be a minimum of 1.5 years since diagnosis	Smokers and former smokers who quit smoking less than 5 years ago, pregnant women, individuals who have undergone periodontal treatment in the last year, undergone antibiotic or anti-inflammatory therapy 3 months prior to inclusion in the study, or who have any other systemic disease, other than type 2 diabetes mellitus, that may alter the course of periodontal disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-6pngwz	Effects of rosuvastatin and sevelamer in coronary calcification in chronic kidney disease patients	other	Intervention	2011-07-20	<NULL>	<NULL>	18	Effects of rosuvastatin and sevelamer in coronary calcification in chronic kidney disease patients not on dialysis	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	<NULL>	UNIVERSIDADE FEDERAL DE SAO PAULO	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-6pngwz	<NULL>	All patients were older than 18 years and were followed by a nephrologist for at least 03 months.	Exclusion criteria were the presence of chronic inflammatory diseases, active malignancy, human immunodeficiency virus (HIV), viral hepatitis and chronic steroids intake.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-93ggrm	Effect of the treatment of oral appliance for obstructive sleep apnea on heart rate variability and on structural and functional characteristics of carotid artery.	other	Intervention	2012-01-04	<NULL>	<NULL>	55	Randomized clinical trial, controled, duble blind, four arms, to evaluate the impact of the treatment of oral appliance for obstructive sleep apnea on heart rate variability and on structural and functional characteristics of carotid artery.	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-30	UNINOVE -Universidade Nove de Julho- São Paulo - SP	UNINOVE -Universidade Nove de Julho- São Paulo - SP	https://ensaiosclinicos.gov.br/rg/RBR-93ggrm	<NULL>	Man and woman, at list with 20 years old, ody mass index lower than 30, with no co-morbidities, apnea/hipopnea index moderate to severe, opening of 40mm, mandibular protriusion 7mm, periodontal health.	Psychiatric deseases, use fo any drugs that interfer in sleep, severe temporomandibular dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-9x5jfn	Effects of manipulation of foot muscles in people who have acquired brain injury	other	Intervention	2012-03-13	<NULL>	<NULL>	152	Manipulation of intrinsic muscles of the foot in people with acquired brain injury	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2011-02-09	Centro Universitário de Rio Preto - UNIRP	Centro Universitário de Rio Preto - UNIRP	https://ensaiosclinicos.gov.br/rg/RBR-9x5jfn	<NULL>	"Patients with acquired brain injury;
Ability to stay in standing position without assistance of the upper limbs."	"Do not assume standing position; 
Age below 18 years; 
Owning a pathology that prevents the collection of results."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-7ynkx6	Study for comparative evaluation of efficacy and safety of nitrendipino (Caltren) versus nifedipino (Adalat retard) in the treatment of mild arteial hypertension.	other	Intervention	2012-02-13	<NULL>	<NULL>	162	Open label, prospective, parallel, multicenter and randomized study for comparative evaluation of efficacy and safety of nitrendipino (Caltren) versus nifedipino (Adalat retard) in the treatment of arteial hypertension stage 1.	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2012-06-01	Libbs Farmaceutica Ltda	Libbs Farmaceutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7ynkx6	<NULL>	"Adult patients over 18 year-old from both genders;

ICF signed by the participant;

Patients diagnosed with hypertension stage 1, according to the definitions and orientations publicized in the VI Brazilian Arterial Hypertension Guidelines."	"fertile women, independently of the use of contraceptive methods;

known hypersensitivity to study medications;

non-adherence to the placebo treatment during the run-in period;

laboratory exams collected in the screening visit considered clinically significant by the investigator;

ECG performed during the screening visit showing ventricular arrhythmia, atrium-ventricular block of 2nd or 3rd degree, arrhythmia, tachycardia, bradycardia, or any other alteration considered clinically significant by the investigator;

Angina pectoris CCS class III or IV;

Decompensate angina pectoris NYHA class II or IV;

BMI over 35 kg/m2;

moderate or advanced hepatic insufficiency;

Severe or decompensate kidney insufficiency, characterized by creatinine clearance lower than 30 mL/min/1,73 m2 of corporal surface or dialyses required;

ongoing severe conditions, even if controlled by therapy: gastrointestinal, immunological, cardiovascular or cancer;

presence or history of significant edema of lower limbs (++/4+ or more);

myocardial infarction, myocardial revascularization or coronary angioplasty in the last 6 months or myocardial revascularization scheduled for the next 6 months;

significant or decompensate cardiac valvulopathy;

stroke or transient ischemic attack in the last 12 months or carotid revascularization scheduled for the next 6 months;

Uncontrolled diabetes (HbA1C over 9%);

history of angioneurotic edema;

any relevant disease that by investigator judgment may interfere in the study objectives or patients’ risks;

psychiatric disease that prevent the patient to participate in the study or cognitive disturbs (demential syndrome of any origin)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-64mbnx	Yôga and Respiratory Techniques on HF Patients	Other	Intervention	2013-09-02	<NULL>	<NULL>	242	Yôga and Respiratory Techniques Training on the Management of Heart Failure Patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	HCPA- UFRGS	HCPA- UFRGS	https://ensaiosclinicos.gov.br/rg/RBR-64mbnx	<NULL>	"Stable HF patients in an ambulatory care setting at ULBRA-Mãe de Deus University Hospital, with a diagnosis of HF with Preserved or Reduced Fraction.
Aged 45 to75 years old.
Functional Class II and III.
No exclusion criteria for physical activity, in accordance with clinical evaluation performed by a cardiologist in charge."	"Not signing the Informed Consent.
Not being able to do physical activity (angina, AMI with less than 6 months and / or stenting with persistent angina, severe valvular disease, chemotherapy, implanted defibrillator, NYHA functional class IV, medium and severe COPD).
Not completing intervention or evaluations."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-6fftwy	Evaluation of walking in patients with Parkinson&apos;s disease who underwent surgery for brain stimulation before and after physical therapy program with exercises and treadmill training with or without body weight support.	Other	Intervention	2013-09-16	<NULL>	<NULL>	249	Three-dimensional analysis of gait in patients with Parkinson&apos;s disease and deep brain stimulation before and after regular cinesioterapia program with treadmill training with and without partial body weight support	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-02	Faculdade de Medicina da Universidade de São Paulo	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6fftwy	<NULL>	Indication of the implant deep brain stimulation; Over 18 years of age, clinical diagnosis of idiopathic Parkinson&apos;s disease according to international criteria, absence of adequate response to treatment with medication or with complications related to prolonged use of L-dopa; Expected to be anesthesia or local anesthesia or general do not incur greater risk than expected in the general population; Ability to understand and sign the consent form; Blood tests, coagulation and normal metabolic; Absence of anatomic abnormalities that preclude access to the implant the electrodes (cranial tumors, intra-cranial and brain cysts), absence of infection or other medical conditions pre-existing non-controlled (diabetes, hypertension, symptomatic pulmonary or cardiac diseases) no use of antiplatelet agents, not being performing concurrent treatment with other experimental drugs; Absence of pregnancy and breastfeeding; conditions psychological, familial, sociological or geographical impossible medical monitoring post-operative Fitness for Motor Training Program, Maintenance of good clinical conditions previously described; Maintenance of all clinics and drug restrictions described; Installation of deep brain stimulation (DBS) for two months at least; DBS working properly at the time of inclusion; Accept and sign the consent form to participate in the training program.	Inability to consent to participate in the study: With uncontrolled infection or other medical conditions pre-existing non-controlled (eg decompensated diabetes, hypertension, pneumonia or symptomatic heart disease), history of primary or secondary myocardial ischemia, congestive heart failure, cardiac arrhythmia, or bundle branch block refractory to treatment, concomitant treatment with other experimental drugs, pregnant or lactating; Conditions psychological, familial, sociological or geographical conditions that preclude medical monitoring post-operative history of orthopedic surgery of lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-4hrrsr	Influence of knee pain on kinematics of knee,ankle and foot during stair descent and immediate effects of an intervention	Other	Intervention	2015-08-15	<NULL>	<NULL>	583	Influence of Patellofemoral Pain Syndrome on 3D kinematics of knee,ankle and foot during stair descent and immediate effects of an intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-20	Escola de Eduacação Física e Esporte da Universidade de São Paulo	Escola de Eduacação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4hrrsr	<NULL>	The inclusion criterias are pain in the patellofemoral joint region for at least two months during squatting, prolonged sitting, descending or ascending stairs.	Any previous knee surgery, history of patellar dislocation or any other limitations that would influence gait.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-6wbpbq	Evaluation of analgesic effect of surgical wound Infiltration of Open Cholecystectomy with Bupivacaine 0.25% with adrenaline in patients of santa casa de misericórdia de Sobral	Other	Intervention	2015-12-23	<NULL>	<NULL>	660	Evaluation of analgesic effect of surgical wound Infiltration of Open Cholecystectomy with Bupivacaine 0.25% with adrenaline in patients of santa casa de misericórdia de Sobral	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-17	Santa Casa de Misericórdia de Sobral	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6wbpbq	<NULL>	They should be included in previously healthy patients; ASA (American Society of Anesthesiologist) 1 or 2; between 18 and 70 years; of both sexes; undergoing elective open cholecystectomy surgery.	People will be excluded who do not agree to answer the questionnaire or refuse to validate the consent form; have any allergies to any of the drugs included in the program &apos;s protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-55g4q3	Effects of a stretching program of the posterior muscles in patients with temporomandibular dysfunction	Other	Intervention	2016-04-01	<NULL>	<NULL>	776	Assessment of pain and mouth opening range of motion in patients with temporomandibular disorders subjected to stretching of the posterior chain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Universidade Sagrado Coração	Universidade Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-55g4q3	<NULL>	Study participants; females; in the age group 20-50 years. diagnosed with temporomandibular dysfunction; who do not use drugs and are not performing any other intervention.	They will be excluded from the study that individuals are making use of analgesic drugs and aantiinflamatório ; also some other type of physical therapy intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-7dscrq	Volumetric evaluation of the face using three-dimensional technology: study on cadaver	Other	Intervention	2016-05-31	<NULL>	<NULL>	875	Volumetric face reviewed: validation of three-dimensional facial image capture system for structured light technology: study on cadaver	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7dscrq	<NULL>	Body to be subjected to autopsy in the Serviço de Óbitos da Capital de São Paulo	Bearded presence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-95smwv	Social Support	Other	Intervention	2018-12-27	<NULL>	<NULL>	2412	Analysis of the independent effect of social support on adherence and success rates of tuberculosis treatment in Brazilian capitals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-21	Conselho Nacional de Pesquisas	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-95smwv	<NULL>	"Patients over 18 years of age, being diagnosed
  with tuberculosis."	Individuals with multidrug-resistant tuberculosis, transferred from other health facilities for more than 15 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:41
RBR-9zzg4d	Evaluation of dental sensitivity after bleaching using a bleaching gel with bioglass nanoparticles	Other	Intervention	2019-11-15	<NULL>	<NULL>	3189	Effect of hydrogen peroxide 35% bioglass nanoparticles-containing on tooth sensitivity for in-office bleaching: A randomized triple blind clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-14	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9zzg4d	<NULL>	Age between 18 and 30 years, regardless of gender; have a voluntary interest in undergoing aesthetic treatment for teeth whitening; agree to the Informed Consent Form (ICF); present from first to first molar, in the upper and lower arches, healthy, without caries lesion and / or restoration with extension to the buccal face of the teeth; present teeth with initial color A2 or higher, according to the Classic Vita scale; present good oral health (absence of injury or any type of alteration suggestive of pathology) and systemic; have good oral hygiene and periodontal health (absence of gingivitis and periodontitis, the latter being considered as the presence of two or more teeth with 3mm probing depth).	Patients who have already undergone teeth whitening treatment; patients with self-reported dental sensitivity (spontaneous and / or provoked); have teeth with severe color change (staining by tetracycline, fluorosis, hypoplastic; and / or traumatized; have teeth endodontically treated, among which will undergo the whitening procedure; are undergoing medical treatment or are using controlled medication; 6. Are using anti-inflammatory and / or analgesic medications, having recessions of gingival tissue and exposure of dentine tissue in the cervical region, having functional and painful symptoms of the mandibular temporomandibular joint (TMJ), having teeth with clinically visible cracks or fracture; orthodontic appliance or any type of prosthetic restoration, female patients who are pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:20
RBR-8x52jd	Study of analysis of pain improvement in patients with sacral pain who underwent interventional procedure in pain with the radiofrequency technique.	Other	Observational	2020-02-10	<NULL>	<NULL>	3466	Retrospective study of the analgesic effect of denervation of sacroiliac joints with radiofrequency in patients with sacral pain	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Ligia Ferreira de Toledo Kawamoto	Ligia Ferreira de Toledo Kawamoto	https://ensaiosclinicos.gov.br/rg/RBR-8x52jd	<NULL>	"The study will be done with approval by the Ethics Committee of the Hospital Vera Cruz and the Federal University of São Paulo. Data from the medical records of patients submitted to radiofrequency for lumbar pain in unilateral or bilateral sacroiliac joint from January 2015 to December 2017 will be collected.
Will be collected from the medical records:
Patient data: age, sex, height, weight
Pain characteristics: location, duration, intensity, start time. Previous treatments
Medications in use for pain and dose
Relief of pain after radiofrequency denervation (X scale), evaluated for X months.
Need for medication or other techniques for pain relief after radiofrequency. Adverse effects and complications"	Patient not submitted only procedure of denervation of the sacroiliac joints with pulsed radiofrequency, conventional or refrigerated techniques.Patients who were not submitted to the procedure from January 2015 to December 2017.Excluded medical records that did not have all the information studied	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:31
RBR-8k4f68	Association of the level of mobility of adult patients in the ICU with the successful removal of mechanical ventilation: protocol for an observational study	Other	Observational	2020-04-30	<NULL>	<NULL>	3793	Association of the mobility level of critically ill patients with the successful withdrawal of mechanical ventilation	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-20	Universiidade Federal de São paulo	Universiidade Federal de São paulo	https://ensaiosclinicos.gov.br/rg/RBR-8k4f68	<NULL>	age 18 to 90 years; admitted to the intensive care unit; under invasive mechanical ventilation for 24 hours or more; with mobility preserved prior to hospitalization.	Neurological disease; neuromuscular disease; degenerative muscle disease; brain or spinal cord trauma; inability to communicate in Portuguese; severe cognitive impairment prior to admission to the ICU; unstable fractures; burns; injury requiring rest prescription; palliative care; amputation of lower members.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:44
RBR-9rrqhk	Effect of an intervention program in the implementation of healthy school canteens	Other	Intervention	2018-07-11	<NULL>	<NULL>	4067	Effect of an intervention program in the implementation of healthy school canteens: a randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal do Rio Grande do Sul	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-9rrqhk	<NULL>	Primary and Secondary Schools of the public and private network of the “Território da Cidadania do Noroeste Colonial”, in RS, that own sales structure in canteen format at the school	Schools with exclusive care for children with special needs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:19:54
RBR-93wgtg	Electrical brain stimulation in children with Autism: Academicals skills and Social Cognition before and after intervention.	Other	Intervention	2020-09-11	<NULL>	<NULL>	4240	Transcranial direct current stimulation in children and adolescents with Autistic Spectrum Disorder: assessment of basic academic skills and social cognition before and after intervention	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-07-30	Universidade Federal de São Paulo	Centro Paulista de Neuropsicologia	https://ensaiosclinicos.gov.br/rg/RBR-93wgtg	<NULL>	Children and adolescent who have a diagnostic of Autism Spectrum Disorder according to DMS-5; age between 6 and 12 year; inserted on regular school environment; have degrees of understanding and collaboration compatible with carrying out the proposed activities; score more than 30 on the CARS scale.	Children with epilepsy; metallic implant in the brain or hearing aids; sensory or motor deficiencies that limit the performance of the procedures proposed in this project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:00
RBR-2hq36d7	Application of modified low-intensity intravascular laser in premature infants with immature lung	Other	Intervention	2020-11-27	<NULL>	<NULL>	4389	Application of modified low-intensity intravascular laser in premature infants with respiratory distress syndrome - type I	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	Hospital Universitário Regional dos Campos Gerais	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2hq36d7	<NULL>	Premature newborn with clinical diagnosis of type I respiratory distress syndrome using invasive or non-invasive ventilatory support.	Newborns with congenital neurological, heart and respiratory diseases that are not associated with RDS type I; newborns with skin lesions at the site of laser application; newborns whose parents or guardians do not sign the Informed Consent Form (ICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:08
RBR-65trt53	Clinical study to assess safety and efficacy related to the use of donor stem cells in the treatment of COVID-19.	Other	Intervention	2020-12-14	<NULL>	<NULL>	4418	"Double-blind, randomized, placebo-controlled study to assess
Safety and Effectiveness of Protection Against SARS-Cov-2 Infection: Infusion of
Mesenchymal Stem Cells (MSCs) from expanded deciduous tooth pulps,
As Allogeneic Therapeutic Strategy."	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2021-04-30	R-Crio Criogenia S.A.	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-65trt53	<NULL>	Man or woman; aged 60 years or over; with laboratory confirmation of the infection (COVID-19) by polymerase chain reaction with reverse transcription (RT-PCR); presence of at least one risk factor (co-morbidity) beyond age; adequate and healthy hematological values; hemoglobin 100 g / L, neutrophils 1.0 x 10 (9) / L, platelets 150 x 10 (9) / L; adequate livre function; ALT and AST 2.5 x ULN, bilirubin 1.5 x ULN;Adequate renal function; calculated creatinine clearance 50 mL / min; written informed consent signed by the candidate.	Patients with severe allergies; serious basic illnesses that affect survival, including blood disorders, cachexia, active bleeding, severe malnutrition; obstructive pulmonary pneumonia, severe pulmonary interstitial fibrosis, alveolar proteinosis, allergic alveolitis and other known viral pneumonia or bacterial pneumonia; continuous use of immunosuppressive agents or organ transplants in the last 6 months; cancer being treated or even treated (a formal opinion from the responsible doctor is required); low adherence and unable to complete the full study; increased risk of the subject or other conditions that interfere with the clinical trial and the judgment of results such as excessive stress, sensitivity or cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:10
RBR-10zs97gk	Use of  self-management strategies combined with multicomponent training for the purpose of social distance from COVID-19 in capacity, physical capacity, mental health and quality of life in the older adults.	Other	Intervention	2021-06-17	<NULL>	<NULL>	4967	Use of self-management strategies combined with multicomponent training to mitigate the effects of social distance from COVID-19 on capacity, physical capacity, mental health and quality of life in the older adults - A blind, randomized and controlled clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal de São Carlos	CAPES	https://ensaiosclinicos.gov.br/rg/RBR-10zs97gk	<NULL>	Heahthy individuals; both gender; living in the community of São Carlos or region; aged 60 or over; preserved walking capacity; who participate in the “Geriatric Revitalization”	Individuals with cognitive deficit assessed by the Mini-Mental State Examination (MMSE &lt;18 points); physical limitations that make it impossible to participate in any of the proposed tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-2fmytmx	What are the common characteristics of patients who need to receive a blood transfusion after total knee replacement surgery?	Other	Observational	2022-04-11	<NULL>	<NULL>	5336	What is the profile of patients candidating for Hemotransfusion after a Total Knee Arthroplasty?	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-05-15	Instituto Nacional de Traumatologia e Ortopedia INTO	Instituto Nacional de Traumatologia e Ortopedia INTO	https://ensaiosclinicos.gov.br/rg/RBR-2fmytmx	<NULL>	patients with knee osteoarthrites undergoing total knee arthroplasty; both genders; no age limits.	patients with previous knee arthroplasty that failed requiring revision surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-4pn5whh	Homeopathic Treatment of Positive Covid-19 Symptomatic Patients	Other	Intervention	2022-04-13	<NULL>	<NULL>	5343	Evaluation of Homeopathic Treatment of Positive Covid-19 Symptomatic Patients in Relation to Physical and Mental Symptoms: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade de Medicina - Universidade do Estado de São Paulo (Unesp) - Campus Botucatu	Faculdade de Medicina - Universidade do Estado de São Paulo (Unesp) - Campus Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4pn5whh	<NULL>	"Patients of both sexes; Present respiratory disease, with at least 3 (three) of the following symptoms: fever, chills, fatigue, myalgia, anorexia, sore throat, cough, expectoration, dyspnea, chest pain, headache, nasal congestion, conjunctival congestion, coryza , anosmia or hyposmia, dysgeusia, abdominal pain, diarrhea, rash; Present physical symptoms related to Covid-19 infection at the time of the first homeopathic consultation (symptomatic patients); Present a positive laboratory test (RT-PCR or serological) confirmed for COVID-19; Be ≥ 18 years of age; Not having the following comorbidities:
 severe heart disease (chronic or congenital), poorly controlled heart failure, poorly controlled COPD and asthma, cystic fibrosis with recurrent infections, chronic kidney disease at an advanced stage or undergoing dialysis, immunosuppressed, solid organ and bone marrow transplants; Sign the Free and Informed Consent Term (ICF) authorizing your participation in the research"	Individuals who no longer wish to participate in the clinical follow-up performed by the physician; Patients who fail to follow the therapeutic guidelines for the use of homeopathic medication as recommended (misuse, discontinuation of use); Asymptomatic patients for Covid-19, even with positive serological test or RT-PCR.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-5fqffpc	Determination of the glycemic index and glycemic load of an ice cream with polydextrose	Other	Intervention	2022-06-30	<NULL>	<NULL>	5457	Determination of the glycemic index and glycemic load of an ice cream rich in polydextrose. A randomized clinical trial	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2021-08-18	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5fqffpc	<NULL>	Volunteers with absence of metabolic disorders, such as diabetes mellitus; absence of cardiovascular, liver or kidney diseases; cancer; thyroid disorders; absence alcoholism; absence of morbid obesity	Children; pregnant women; elderly, individuals with allergies and/or intolerance to any component of the formulations;  who do not provide authorization by signing the Informed Consent Term; who did take medications in the past three months that affect glycemic metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-2rvwstz	Efficacy of cardiac biofeedback in control shortness of breath and improving functional capacity in COVID-19 survivors	Other	Intervention	2024-02-08	<NULL>	<NULL>	6778	Efficacy of Cardiac Biofeedback in Controlling Dyspnea and improving Functionally Capacity in post covid syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-29	Unifacisa	Universidade Federal de São Carlos- UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-2rvwstz	<NULL>	Patients who prove RT-PCR negative for COVID-19 performed at the place of hospitalization following criteria for hospital discharge; who developed a moderate to severe form of the disease; who were hospitalized and admitted to an intensive care unit (ICU) will be included in the study, intermediate care unit or ward; undergoing invasive (via orotracheal tube or tracheostomy) or non-invasive mechanical ventilation and oxygen therapy (high-flow nasal atheter or mask with reservoir bag); who were discharged at least 30 days before the start of rehabilitation.	Participants who certify reinfection, rehospitalization and hospital admission will be excluded from the study; hemodynamically unstable patients (uncontrolled blood pressure and heart rate); unstable medical conditions (e.g., cardiovascular and pulmonary disorders - arrhythmias, decompensated atrial fibrillation, pulmonary thromboembolism, acute heart failure, pulmonary congestion, acute myocardial infarction and stroke); with severe pulmonary, cardiac or functional sequelae that require a more complete rehabilitation program, or cognitive conditions; dementia that makes it impossible to answer the questionnaires; finally those with confirmed mental disorders and who require sychological intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-109j9jww	Open bite treatment with fixed palatal crib with and without myofunctional therapy: a randomized clinical trial	Other	Intervention	2024-07-03	<NULL>	<NULL>	7117	Efficacy and efficiency of open bite treatment with fixed palatal crib with and without myofunctional therapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-109j9jww	<NULL>	Mixed dentition; 6 to 8 years of age; both genders; presence of permanent first molars and central incisors in the dental arches; overbite of -1millimeter or less; absent or mild dental crowding; absence of posterior crossbite; history of at least one deleterious habit	Patients with history of previous orthodontic treatment; presence of dental or supernumerary agenesis; loss of permanent teeth; presence of craniofacial anomalies and associated syndromes or any other type of systemic or neurological alteration that would make it impossible to perform the procedures of intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-3gbr5h7	Influence of torque, bone type and bone loss on the stability of cylindrical external hexagon and morse cone implants with new surface treatment	Other	Intervention	2024-07-16	<NULL>	<NULL>	7138	Influence of insertion torque, recipient bone type and peri-implant bone loss on the primary and secondary stability of external hexagon and morse cone cylindrical implants with new surface treatment	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-03-14	Faculdade de Odontologia - Campus de Araçatuba da Universidade Estadual Paulista	Faculdade de Odontologia - Campus de Araçatuba da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3gbr5h7	<NULL>	Age between 18 and 60 years; cognitive capacity; presence of healthy tissues and satisfactory bone quantity and quality; with need for rehabilitation with single or three element implant supported prostheses with pontic	Patients with parafunction; as well as those with harmful habits and addictions; such as drug users; alcohol abusers and smokers; patients with systemic disorders (diabetes; transplant patients) or who use medications that alter bone metabolism (corticoids; cyclosporine A; radiotherapy) and patients in need of bone grafting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-35q7s3v	Degradation rate of bleaching gels during in-office tooth bleaching	Other	Intervention	2023-05-16	<NULL>	<NULL>	7154	Clinical degradation rate of bleaching gels with different acidities during in-office tooth bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-35q7s3v	<NULL>	Patients aged 18 years or older; male or female; in good general and oral health; the premolars, canines and incisors of the maxilla and mandible they need to be free of caries lesions, restorations or endodontic treatments; the canines superiors must present WId values ​​lower than 20, evaluated with a digital spectrometer (Vita Easyshade, Vita Zahnfabrik, Bad Säckingen, Germany)	Pregnant or lactating patients; smokers; with bruxism; severe internal discoloration (tetracycline stains, fluorosis, teeth pulped); dentine hypersensitivity; gingival recession or undergoing orthodontic treatment; participants who use anti-inflammatories, analgesics or antioxidants daily; patients who have already undergone tooth whitening procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-4bk3yjb	Inspiratory muscle training and Inflammatory bowel disease	Other	Intervention	2025-04-04	<NULL>	<NULL>	7891	Effects of inspiratory muscle training on cardiovascular autonomic control and systemic inflammation in patients with Inflammatory bowel disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-06	Instituto Biomédico	Instituto Biomédico	https://ensaiosclinicos.gov.br/rg/RBR-4bk3yjb	<NULL>	Men and women; minimum age of 18 and a maximum of 60 years; participants with inflammatory gastrointestinal diseases in remission for 3 months; participants with the ability to walk independently; participants with no change in medication for at least 30 days prior to the start of the testing protocol; complete blood count, liver enzymes and inflammatory markers performed no more than 30 days ago	History of chronic or acute cardiorespiratory disease, except controlled arterial hypertension; acute pathologies that affect blood pressure and breathing; body mass index &lt; 17 or &gt; 35 kg/m2; cardiac arrhythmia that prevents measurement of cardiac autonomic control; anemia; smoking; previously diagnosed respiratory disorders and lung capacity below 80% of the value predicted by spirometry; severe postural deviation in the sternum or spine such as scoliosis, hyperkyphosis or hyperlordosis that influence the respiratory pattern; osteomyoarticular dysfunction that alters gait and requires assistive devices for walking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-3775776	Effects of Curcumin supplementation associated with resistance training on muscle gain, maximal strength, and blood markers in strength training practitioners: a randomized, double-blind clinical trial	Other	Intervention	2025-05-07	<NULL>	<NULL>	7989	Effects of Curcumin supplementation associated with resistance training on muscle hypertrophy, maximal strength, and biochemical biomarkers in strength training practitioners: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-21	União Brasileira de Educação e Assistência	União Brasileira de Educação e Assistência	https://ensaiosclinicos.gov.br/rg/RBR-3775776	<NULL>	Adult male bodybuilders; age 20 to 35; who have been bodybuilding for at least six months; practitioners who include at least three weightlifting physical activity sessions per week	Individuals diagnosed with any chronic disease or condition such as hypertension ; type 1 or type 2 diabetes mellitus ; as well as those using dietary supplements or medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-5hjstkg	Evaluation of ealing following mandibular third molar Extraction using a Modified Suture Technique	Other	Intervention	2025-08-01	<NULL>	<NULL>	8182	Evaluation of morbidity, healing, and periodontal parameters in the Extraction of erupted mandibular third molars using a Modified Flap Suture Technique	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5hjstkg	<NULL>	Inclusion criteria for the sample of this study will be: Volunteers of both genders aged between 18 and 35 years old; Presence of both erupted lower third molars with indication for surgical removal; No use of medications that influence bone or soft tissue regeneration; Presence of erupted and healthy second molars; No active odontogenic infection episodes; Individuals who agree to sign the Informed Consent Form (ICF); No previously diagnosed Temporomandibular Disorders (TMD); No neuropathic facial pain; No allergic reaction to any of the medicinal or pharmacological compounds used in the pre or postoperative protocol	Exclusion criteria were as follows: Failure to attend postoperative follow-up appointments; Occurrence of flap lacerations during surgery; Fracture of the second molar crown during third molar extraction; Exceeding 40 minutes between incision and suturing; Significant discrepancy in duration between the first and second surgeries; Withdrawal of consent at any time; Participants with special needs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-9tgfkmy	Effects of dog therapy and aromatherapy on institutionalized elderly people	Other	Intervention	2025-11-06	<NULL>	<NULL>	8493	Effects of integrative therapies on institutionalized elderly people: use of essential oils and dog-assisted therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Departamento de Saúde Coletiva da Universidade Federação do Rio Grande Norte	<NULL>	<NULL>	<NULL>	Institutionalized elderly individuals aged ≥ 60 years; both sexes; score ≤ 25 on the Mini Mental State Examination (MMSE); signed informed consent	Elderly people afraid of dogs; allergy to dogs; dog phobia; non-residents in Long-Term Care Institutions for the Elderly	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-7kvxw88	Study on the effects of alternating between sitting and standing during office work on adults’ health, comfort, and well-being	Other	Intervention	2025-11-14	<NULL>	<NULL>	8508	Effects of postural alternation during office work on autonomic function, hemodynamics, comfort, productivity, cognitive function, energy expenditure, and mood in adults: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-25	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Men and women; between 18 and 40 years old; office workers	History of cardiovascular or metabolic diseases; infectious or inflammatory processes; severe chronic pain conditions; smokers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:29
RBR-4v87t3q	Testosterone and sexual desire in postmenopausal women with testosterone gel	Other	Intervention	2026-01-12	<NULL>	<NULL>	8732	Testosterone Levels and Sexual Desire in Postmenopausal Women After Transdermal Testosterone Use	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-01	Programa de Pós Graduação em Tocoginecologia	<NULL>	<NULL>	<NULL>	Postmenopausal women aged 50 to 60 years; with 12 months of amenorrhea; a sexual partner; normal gynecological examinations within the past twelve months; and reduced sexual desire	Smokers; women with a history of chronic venous disease, cerebrovascular disease, cardiovascular disease, migraine with aura, hepatic diseases, elevated liver enzymes, malignant disease, or a partner with sexual dysfunction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-9h45v9v	Treatment of Knee with Shockwave Therapy	Other	Intervention	2026-01-14	<NULL>	<NULL>	8751	Treatment of Knee Osteoarthritis with Shockwave Therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-19	Universidade Católica de Brasília - UCB	<NULL>	<NULL>	<NULL>	Both sexes; aged between 60 and 79 years; diagnosed with KOA confirmed by radiographic evidence, according to Ahlbäck&apos;s radiological classification on X-ray; being able to understand the study and voluntarily agree to participate, being accompanied by family members and after comprehension is observed by the interviewer; having no restrictions regarding the use of TOCE	Previous treatment with TOCE or any other treatment for knee osteoarthritis in the last six months; active infection in the knee joint; having undergone viscosupplementation in the knee less than a year ago; meeting at least one of the following contraindications: use of a pacemaker; diagnosis of deep vein thrombosis (DVT); diagnosis of cancer at any stage; patient having a blood coagulation abnormality (coagulopathy), or taking any type of anticoagulant; primary malignant disease (tumors) in the treatment area; acute soft tissue or bone infection; systemic infections; epilepsy; corticosteroid infiltration at the application site in the last 6 weeks; patient at high risk from any type of anesthesia or analgesia if it eventually needs to be used	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-688ffs9	Quality of life and oral health of individuals with traditional dentures and improved chewing function	Other	Intervention	2026-04-16	<NULL>	<NULL>	9114	Satisfaction, quality of life and oral health of complete denture wearers, associated with the masticatory function with interchangeable occlusal schemes	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-16	Universidade Estadual Paulista Júlio de Mesquita Filho	<NULL>	<NULL>	<NULL>	Participants of both sexes. Aged 45 years or older. Complete denture wearers with a need for replacement based on patient desire or clinical judgment, such as inadequate intermaxillary relationships and/or severe wear of artificial teeth. Individuals willing to participate in the research and receive the proposed treatment. Good comprehension of spoken Portuguese. Mandibular ridges classified as resorbed according to the methods described by Marcello-Machado et al. and Cawood and Howell. Normal unstimulated salivary flow rate between 0.3 and 0.4 mL/min. Edentulism time of at least 1 year prior to denture replacement	Debilitating systemic changes. Signs/symptoms of temporomandibular disorders. Refusal to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-6r876vt	Effect of simulation versus lecture on surface cleaning and disinfection: a quasi-experimental study	Other	Intervention	2026-04-27	<NULL>	<NULL>	9143	Effect of simulation training and interactive lecture-based teaching on the surface cleaning and disinfection process	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Mato Grosso do Sul	<NULL>	<NULL>	<NULL>	Nursing and cleaning professionals actively and directly involved in the cleaning and disinfection process at the medical clinic unit during the study period; professionals of both genders; professionals aged 18 years or older; professionals working on a 12 by 36-hour shift schedule (twelve hours of work followed by thirty-six hours of rest), covering both even and odd shifts	Professionals who are not directly responsible for the cleaning and disinfection process due to being in managerial or administrative roles; interns and students from technical or undergraduate courses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-48pb9h	A Randomized Double-Blinded Phase II Study of Carboplatin/Paclitaxel/CT-322 versus Carboplatin/Paclitaxel/Bevacizumab as First-Line Treatment for Recurrent or Advanced Non-Small Cell Lung Cancer with Non-Squamous Histology	recruiting	Intervention	2011-06-13	<NULL>	<NULL>	3	A Randomized Double-Blinded Phase II Study of Carboplatin/Paclitaxel/CT-322 versus Carboplatin/Paclitaxel/Bevacizumab as First-Line Treatment for Recurrent or Advanced Non-Small Cell Lung Cancer with Non-Squamous Histology	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2010-07-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-48pb9h	<NULL>	"Subjects must sign an informed consent prior to any study-related procedures.
 Histologically or cytologically confirmed, stage IIIB (malignant pleural effusion), stage IV or recurrent Non Small Cell Lung Cancer;
 Measurable disease by Response Evaluation Criteria In Solid Tumors guidelines, with at least 1 target lesion outside any previous radiotherapy field;
 Eastern Cooperative Oncology Group performance status &lt; 1;
 Life expectancy of at least 3 months;
 Accessible for treatment and follow-up. Subjects enrolled in this trial must be treated at the participating center(s).
 Willing to give a whole blood sample for the study of proteins and genetic polymorphisms in genes related to the Vascular Endothelial Growth Factor signaling pathway.
 Men and women, ages &gt;18 years.
Women of childbearing potential must be using an adequate method of contraception to avoid pregnancy throughout the study [and for up to 6 weeks after the last dose of investigational product] in such a manner that the risk of pregnancy is minimized.
Women of childbearing potential include any female who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Postmenopause is defined as:
Amenorrhea &gt; 12 consecutive months without another cause or 
• For women with irregular menstrual periods and on hormone replacement therapy (HRT), a documented serum follicle stimulating hormone level &gt; 35 International Units/mL
Women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
Women of childbearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 International Units/L or equivalent units of Human Chorionic Gonadotropin) within 72 hours prior to the start of investigational product."	"Women of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period [and for up to 6 weeks after the last dose of investigational product]
Women who are pregnant or breastfeeding 
Women with a positive pregnancy test on enrollment or prior to investigational product administration
Sexually active fertile men not using effective birth control if their partners are Women of childbearing potential.
Evidence of predominantly squamous-cell histology (mixed cell type tumors only)
Known central nervous system metastasis
Less than 28 days elapsed following major surgery 
Excessive risk of bleeding such as history of clinically significant bleeding diathesis or coagulopathy including platelet function disorder (eg, known hemophilia or von Willebrand disease) or acquired bleeding disorder within 12 months (eg, acquired anti-factor VIII antibodies)
Gross hemoptysis (&gt;= 1/2 tablespoon of red blood)
Subjects receiving therapeutic anticoagulation
Thrombotic or embolic cerebrovascular accident including transient ischemic attacks within the past 12 months
Uncontrolled hypertension (defined as systolic blood pressure &gt;150 mmHg or diastolic &gt; 90 mmHg, measured repeatedly at &gt;=2 visits despite adequate treatment with &gt;= 2 antihypertensive drugs)
Clinically significant cardiovascular disease, including (but not limited to) the following:
 Myocardial infarction within the past 6 months
 Unstable angina
 New York Heart Association class II-IV congestive heart failure
 Serious cardiac arrhythmia (eg ventricular arrhythmia, high-grade atrioventricular block), not controlled by medication or requiring medication which might interfere with regularity of study treatment
 Left ventricular ejection fraction below institutional lower limit of normal as measured by 2-dimensional echocardiogram or cardiac MUGA scan.
 History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months
 Serious non-healing wound, active peptic ulcer, non-healing bone fracture, or bleeding skin metastases
 Glomerulonephritis or other protein-wasting glomerulopathy
 Active clinically significant infection(&gt; Grade 2) requiring the use of antimicrobial agents, or that would otherwise, in the opinion of the investigator, interfere with the ability the subject to participate
 Any concurrent malignancy other than non-melanoma skin cancer, or carcinoma in-situ of the cervix
 Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent
 Any serious uncontrolled medical disorder that, in the opinion of the investigator, would impair the ability of the subject to receive study therapy.
Hemoglobin &lt;9.0 g/dL, Absolute Neutrophil Count &lt;1500 cells/mm3, Platelets &lt;100,000 cells/mm3
Serum creatinine &gt;1.5 mg/dL
Calculated creatinine clearance &lt;50 mL/min (using Cockcroft and Gault formula)
Urine protein/creatinine ratio &gt; 1
Serum total bilirubin &gt;1.5 times the institutional upper limit of normal, unless due to Gilbert’s disease
Alanine transaminase or aspartate aminotransferase &gt;2.5 times the institutional upper limit of normal (&gt;5 times upper limit of normal for subjects with documented liver metastases)
Serum amylase and lipase &gt;1.5 times the upper limit of normal
Known hypersensitivity to any of the investigational products or excipients, including Cremophor EL®
Any prior antineoplastic systemic regimens for NSCLC. Subjects must not initiate any concurrent antineoplastic therapy while on study.
Prisoners or subjects who are involuntarily incarceratedSubjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness

Eligibility criteria for this study have been carefully considered to ensure the safety of the study subjects and to ensure that the results of the study can be used. It is imperative that subjects fully meet all eligibility criteria."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-7spw98	A Phase III Open Label, Randomized, 2 Arm Study of Ixabepilone Administered Every 21 Days Versus Paclitaxel Or Doxorubicin Administered Every 21 Days in Women with Advanced Endometrial Cancer Who Have Previously Been Treated with Chemotherapy	recruiting	Intervention	2011-06-21	<NULL>	<NULL>	4	A Phase III Open Label, Randomized, 2 Arm Study of Ixabepilone Administered Every 21 Days Versus Paclitaxel Or Doxorubicin Administered Every 21 Days in Women with Advanced Endometrial Cancer Who Have Previously Been Treated with Chemotherapy	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-03-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7spw98	<NULL>	"All subjects must be informed of the investigational nature of this study and must
sign and give written informed consent in accordance with institutional and
federal guidelines.
Histologic or cytologic diagnosis of endometrial carcinoma.
Evidence that the cancer is locally advanced, recurrent or metastatic and not
curable by local measures (ie, surgery, radiation).
Karnofsky performance status (KPS) 70, 80, 90, or 100 (see Appendix 2).
Subjects must have measurable or non-measurable disease (see Section 6.4.3) that
has progressed since last treatment. A maximum of 140 subjects with
non-measurable disease will be randomized.
Notes:
 If the subject’s only disease is confined to a solitary lesion, its neoplastic
nature must be confirmed by histology or cytology.
 Disease in a previously irradiated field is acceptable as the only site of
measurable disease only if there has been clear progression since completion
of radiotherapy.
 All therapy directed at endometrial cancer must be discontinued 21 days prior to start of treatment, except for hormonal therapy which must be discontinued at
least 1 week prior to start of study treatment. Note: concurrent administration of hormone replacement therapy is allowed.
Subjects must have received one and only one prior chemotherapy (ie, cytotoxic)
regimen for locally advanced, recurrent or metastatic endometrial cancer. Subjects
with 1 additional prior chemotherapy regimen in the neoadjuvant or adjuvant
setting are allowed. Adjuvant/neoadjuvant therapy is defined as post or
preoperative therapy for Stage 1, 2, or 3 disease.
 Subjects may have received any number of prior non-cytotoxic regimens such as
monoclonal antibodies, cytokines, signal transduction inhibitors, or hormonal
therapy.
 Previous radiation therapy is allowed.
Women, ages 18 to older.
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 4 weeks after the last dose of investigational product in such a manner that the risk of pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
  Amenorrhea ? 12 consecutive months without another cause or
  For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level &gt; 35 mIU/mL
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 4 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding.
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Carcinosarcoma (malignant mixed mullerian tumor)
Endometrial leiomyosarcoma and endometrial stromal sarcomas.
Subjects with no prior chemotherapy (ie, cytotoxic) for locally advanced,
recurrent or metastatic endometrial cancer or subjects that received 2 or more
prior chemotherapy (ie, cytotoxic) regimens for locally advanced, recurrent or
metastatic endometrial cancer.
Subjects with known brain metastases. Note: brain scans are not required.
Receipt of prior ixabepilone therapy.
Concurrent active infection requiring antibiotics or other therapy.
Concurrent unstable disease or other debilitating illness that could jeopardize
participation such as congestive heart failure, unstable angina, myocardial
infarction or other cardiac disease within last 6 months.
For subjects whose prior therapy did not include an anthracycline (eg,
doxorubicin) and therefore may be randomized to doxorubicin, LVEF of &lt; 50%
as measured by multi-gated radionuclide angiography (MUGA) or
echocardiography (ECHO).
History of prior malignancy within last 5 years except non-melanoma skin cancer,
carcinoma in situ of the cervix, or carcinoma in situ of the breast not treated with chemotherapy.
Known human immunodeficiency viral (HIV) infection.
Psychiatric disorders or other conditions rendering the subject incapable of
complying with the requirements of the protocol.
Absolute neutrophil count (ANC) &lt; 1500/mm3.
Platelets &lt; 100,000/ mm3.
Hemoglobin &lt; 9 g/dL.
Total bilirubin &gt; 1.5 times the institutional upper limit of normal (ULN), except for subjects with Gilbert’s disease.
AST or ALT &gt; 2.5 times the institutional upper limit of normal (ULN).
Serum creatinine &gt; 1.5 x institutional upper limit of normal (ULN).
Grade ? 2 neuropathy (sensory or motor).
Known allergy to any of the study drugs or their excipients such as, prior severe
HSR to agents containing Cremophor® EL.
No concurrent therapy directed at endometrial cancer (chemotherapy, hormonal,
or investigational during the study).
Subjects must not continue or institute treatment with the following strong
inhibitors of CYP3A4 from 72 hours prior to the initiation of study therapy until
end of treatment with ixabepilone or paclitaxel: Ketoconazole, itraconazole,
clarithromycin, atazanavir, nefazodone, saquinavir, telithromycin, ritonavir,
amprenavir, indinavir, nelfinavir, delavirdine, or voriconazole (See IB1).
Other concurrent anti-tumor, chemotherapy, hormonal therapy, immunotherapy
regimens or radiation therapy, standard or investigational therapy (see
Section 5.5).
Prisoners or subjects who are involuntarily incarcerated.
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-84sdd6	A Randomized, Double-blind, Multi-center Phase III Study of Brivanib versus Sorafenib as First-line Treatment in Patients with Advanced Hepatocellular Carcinoma	recruiting	Intervention	2011-06-27	<NULL>	<NULL>	5	A Randomized, Double-blind, Multi-center Phase III Study of Brivanib versus Sorafenib as First-line Treatment in Patients with Advanced Hepatocellular Carcinoma	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2010-05-01	Bristol-Myers Squibb	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-84sdd6	<NULL>	"Voluntary signed and dated written informed consent form in accordance with
regulatory and institutional guidelines obtained before the performance of any
protocol-related procedures not part of normal patient care.
Histologic or cytologic confirmed diagnosis of HCC.
Advanced HCC
 disease not eligible for surgical and / or locoregional therapies
 progressive disease after surgical and / or locoregional therapies
Child-Pugh Class A 
ECOG performance status 0-1 
Life expectancy of at least 12 weeks
Accessible for treatment and follow-up
Locoregional therapy must be completed at least 3 weeks prior to the baseline
scan; previously treated lesions are not to be selected as target lesions.
At lease one measurable untreated lesion. All subjects must have at least one
previously un-treated, uni-dimensionally measurable lesion by CT or MRI scan &gt;=
20mm. Target lesions that are previously un-treated and are uni-dimensionally
measurable by spiral CT scan to be &gt;= 10mm will be permitted.
 The lesion can be accurately measured uni-dimensionally according to RECIST criteria
 The lesion has not been previously treated with surgery, radiotherapy, and /or
locoregional therapy (eg: radiofrequency ablation (RFA), percutaneous
ethanol or acetic acid injection (PEI / PAI), transcatheter arterial
chemoembolization (TACE) or cryoablation, etc.)
 Bone metastases are not considered measurable lesions.
Adequate hematologic function with absolute neutrophil counts &gt;= 1,500/mm3,
platelet count &gt;= 60 x 109/L, and hemoglobin &gt;= 8.5 g/dL
Adequate hepatic function with serum total bilirubin &lt;= 3 mg/dL, serum albumin
&gt;= 2.8 g/dL and ALT and AST &lt;= 5 times the institutional upper limits of normal
Amylase and lipase &lt;= 1.5 times the institutional upper limit of normal
Adequate renal function with serum creatinine &lt;= 2.0 mg/dL
International normalized ratio (INR) &lt;= 2.3 or Prothrombin time (PT) &lt;= 6 seconds
above control
Left ventricular ejection fraction (LVEF) &gt;= 50% as measured by 2-D Echocardiogram
All laboratory test finding should be stable within the range listed in 3a) - 3f)
without continuous supportive treatment, such as blood transfusion, coagulation
factors and / or platelet infusion, red / white blood cell growth factor
administration, albumin infusion, ursodeoxycholic acid, or drug treatment for
lowering liver enzyme / bilirubin, etc
Men and women, ages 18 or older
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 12 weeks
after the last dose of investigational product in such a manner that the risk of
pregnancy is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined as:
   Amenorrhea &gt;= 12 consecutive months without another cause or
   For women with irregular menstrual periods and on hormone replacement
therapy (HRT), a documented serum follicle stimulating hormone (FSH) level
&gt; 35 mIU/mL
Women who are using oral contraceptives, other hormonal contraceptives (vaginal
products, skin patches, or implanted or injectable products), or mechanical
products such as an intrauterine device or barrier methods (diaphragm, condoms,
spermicides) to prevent pregnancy, or are practicing abstinence or where their
partner is sterile (eg, vasectomy) should be considered to be of childbearing
potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP.
Brain metastasis or evidence of leptomeningeal disease
Known fibrolamellar HCC or mixed cholangiocarcinoma and HCC
History of encephalopathy
Ascites
Evidence of portal hypertension with bleeding esophageal or gastric varices
within the past 2 months
Main portal vein* or vena cava thrombosis or occlusion.
* Main portal vein is defined as the part of the portal vein between the inferior vena cava and the first bifurcation into the left and right vein. It is usually located in the porta hepatis.
Previous or concurrent cancer that is distinct in primary site or histology from
HCC, except cervical carcinoma in situ, treated basal cell carcinoma, superficial
bladder tumors (Ta, Tis &amp; T1). Any cancer curatively treated &gt; 5 years prior to
entry is permitted.
History of active cardiac disease:
  Uncontrolled hypertension which defined as systolic blood pressure greater
than 150 mmHg or diastolic pressure greater than 90 mmHg despite optimal
medical management
  Congestive heart failure NYHA (New York Heart Association) class 3 and 4
  Active coronary artery disease, unstable or newly diagnosed angina or myocardial infarction less than 12 months prior to study entry
  Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta
blockers or digoxin
Valvular heart disease &gt;= CTCAE Grade 2
QTc (Fridericia) &gt; 450 msec on two consecutive ECGs. (baseline ECG should be
repeated if QTc is found to be &gt; 450 msec)
Thrombotic or embolic events within the past 6 months, such as a cerebrovascular
accident (including transient ischemic attacks), pulmonary embolism
Any other hemorrhage/bleeding event &gt;= CTCAE Grade 3 within 4 weeks except
for esophageal or gastric varices
Active infection, less than 7 days after completing systemic antibiotic therapy
Active, untreated hepatitis B
Psychiatric illness/social situations that would limit compliance with study
requirements
History of non-healing wounds or ulcers, or bone fractures within 3 months of
fracture
Major surgical procedure, open biopsy, or significant traumatic injury less than 3
weeks or those who receive minor surgical procedures (eg core biopsy or fine
needle aspiration) within 1 week
History of organ allograft or on an allograft waiting list
Portal-caval shunts
Inability to swallow tablets or untreated malabsorption syndrome
Pre-existing thyroid abnormality with thyroid function that cannot be maintained
in the normal range with medication
History of human immunodeficiency virus (HIV) infection
Substance abuse, medical, psychological or social conditions that may interfere
with the patient’s participation in the study or evaluation of the study results.
Any medical condition that is unstable or which could jeopardize the safety of the
patient and his/her compliance in the study.
Positive pregnancy test
Baseline serum sodium &lt; 130 mmol/L
Baseline serum potassium &lt; 3.5 mmol/L (potassium supplementation may be
given to restore the serum potassium above this level prior to study entry)
Known or suspected history of allergy to brivanib or sorafenib or any agents
given in association with this trial
Prior use of any systemic anti-cancer chemotherapy, immunotherapy or molecular
targeted agents for HCC
Concomitant treatment with rifampin (and its analogues), or St John’s wort
Prior use of systemic investigational agents for HCC
Radiotherapy within 4 weeks prior to start of study drug
Required anticoagulation therapy with an agent such as coumadin, warfarin or
heparin
Required chronic anti-platelet therapy (aspirin at dose &gt;= 300 mg/day, clopidogrel
at dose &gt;= 75 mg/day)
Prisoners or subjects who are involuntarily incarcerated
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-5hzmjx	"A Phase II Study of Dasatinib Therapy in Children and Adolescents with Ph+ Leukemia
with Resistance or Intolerance to Imatinib"	recruiting	Intervention	2011-06-27	<NULL>	<NULL>	6	"A Phase II Study of Dasatinib Therapy in Children and Adolescents with Ph+ Leukemia
with Resistance or Intolerance to Imatinib"	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2010-03-01	Bristol-Myers Squibb	Bristol-Myers Squibb	https://ensaiosclinicos.gov.br/rg/RBR-5hzmjx	<NULL>	"Written informed consent from subject, or from parents or legal guardians for
minor subjects, according to local law and regulation.
    Cohort #1: Subjects must have Ph+ CML in CP which is defined by the
presence of all the following criteria:
  &lt; 15% blasts in peripheral blood and bone marrow
  &lt; 20% basophils in peripheral blood
  &lt; 30% blasts + promyelocytes in peripheral blood and bone marrow
  &gt;= 100 X 109 platelets/L unless thrombocytopenia secondary to recent
treatment
  No extramedullary involvement other than liver or spleen
  Ph+ or variant must be demonstrated by bone marrow cytogenetics
   Cohort #2: Subjects must have Ph+ ALL or Ph+ AP- or BP-CML:
 Ph+ ALL have to be in first or subsequent relapse [ &gt;= 25% blasts in bone
marrow] or fail to achieve remission after imatinib
 AP-CML must meet at least one of the following criteria:
 &gt;= 15% but &lt; 30% blasts in peripheral blood or bone marrow
 &gt;= 30% blasts + promyelocytes in peripheral blood and in bone marrow
(but percent alone has to be &lt; 30%)
 &gt;= 20% basophils in peripheral blood or bone marrow
 &lt; 10 X 109/L platelets unrelated to therapy
  BP-CML has to meet all the following criteria:
 &gt;= 30% blasts in peripheral blood or bone marrow
 Presence of extramedullary blastic disease other than lymph nodes,
liver or spleen
 Subjects have to be proven resistant or intolerant to imatinib:
 For both cohorts, intolerance to imatinib is defined as the occurrence of any
toxicity grade &gt;= 3 considered at least possibly related to imatinib and that led
to discontinuation of previous imatinib therapy.
 For Cohort #1, resistance to imatinib must meet at least one of the following
criteria:
 Failure to achieve, or loss of, CHR after &gt;= 3 months of imatinib at a
daily dose of 260 mg/m2 or greater;
 Failure to achieve MCyR after &gt;=6 months or CCyR after &gt;= 12 months of imatinib therapy at a daily dose of 260 mg/m2 or greater;
 Absolute increase of &gt;= 30% of the percentage of Ph+ metaphases,
confirmed at &gt;= 6 week interval, after prior MCyR to imatinib at a daily
dose of 260 mg/m2 or greater.
 For Cohort #2, resistance to imatinib must meet at least one of the following
criteria:
 Failure to achieve CHR while on imatinib after a &gt;= 4-week treatment
or a &gt;= 50% increase in peripheral blood blasts over a 2-week period
 Subjects who achieved a CHR subsequently no longer meet the criteria
consistently over a consecutive 2-week period while receiving imatinib
 Absolute increase of &gt;= 30% of the percentage of Ph+ metaphases,
confirmed at &gt;= 6 week interval, after prior MCyR to imatinib.
 Lansky or Karnofsky scale &gt; 50 
 Life expectancy &gt;= 12 weeks
 Subjects must have recovered to baseline or Grade 1 (NCI CTCAE, version 3.0)
from the toxicities (except alopecia) resulting from recent therapies, including
chemotherapy, hormonal therapy, immunotherapy, biological therapy or
investigational product and radiation therapy.
 Serum Na, K, NaHC03, Mg, P and Ca levels within institutional normal limits
and AST, ALT, bilirubin, BUN or urea, creatinine ? Grade 2 (NCI CTCAE,
Version 3.0).
 Men and women, age &gt;= 1 to &lt; 21 years.
Women of childbearing potential (WOCBP) must be using an adequate method of
contraception to avoid pregnancy throughout the study and for up to 4 weeks after
the last dose of investigational product in such a manner that the risk of pregnancy
is minimized.
WOCBP include any female who has experienced menarche and who has not
undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation,
or bilateral oophorectomy) or is not postmenopausal. Post menopause is defined
as:
• Amenorrhea &gt;= 12 consecutive months without another cause or
• For women with irregular menstrual periods and on hormone replacement
therapy [HRT], a documented serum follicle stimulating hormone [FSH] level
&gt; 35 mIU/mL)
Women who are using oral contraceptives, other hormonal contraceptives
(vaginal products, skin patches, or implanted or injectable products), or
mechanical products such as an intrauterine device or barrier methods
(diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing
abstinence or where their partner is sterile (eg, vasectomy) should be considered to be of childbearing potential.
WOCBP must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 72 hours prior to the start of investigational product."	"WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 12 weeks after the last dose of
investigational product.
Women who are pregnant or breastfeeding
Women with a positive pregnancy test on enrollment or prior to investigational
product administration.
Sexually active fertile men not using effective birth control if their partners are WOCBP who are unwilling or unable to use an acceptable method to avoid
pregnancy for the entire study period and for up to 4 weeks after the last dose of
investigational product.
Subjects for whom potentially-curative therapy is available, including
hematopoietic stem-cell transplantation (HSCT) at the time when subject is
assessed for enrollment
Subjects with isolated central nervous system disease are excluded from study.
This criterion relates to subjects with CNS-3 disease (? 5 leukemic blasts per
cubic millimeter in a sample with &lt; 10 erythrocytes per cubic millimeter).
Subjects with CNS-1 (no detectable blast cells in a sample of cerebrospinal fluid)
and CNS-2 (&lt; 5 leukemic blast cells in a sample with &lt; 10 erythrocytes per cubic
millimeter) are eligible for study. Subjects with a combined relapse which also
involves the CNS are eligible, provided this is asymptomatic (no convulsions or
other neurological symptoms).
Isolated extramedullary disease, with &lt; 5% blasts in bone marrow
Any serious uncontrolled medical disorder that would impair the ability of the subject to receive protocol therapy, including:
 Ongoing uncontrolled infection
 Clinically-significant disorder of platelet function (e.g. von Willebrand’s
disease) or ongoing gastrointestinal bleeding
 Clinically-significant cardiovascular disease, congenital long QT syndrome,
history of ventricular arrhythmias or heart block, or prolonged QTc interval &gt;
450 ms (Fridericia correction) on baseline electrocardiogram
 Subjects diagnosed with the T315I mutation (mutation testing should be
performed according to the investigator’s standard practice and is not
mandatory at sites without BCR-ABL testing available).
 Subjects who have experienced hypersensitivity to dasatinib or to any of the excipients. Inactive ingredients in dasatinib tablets include: lactose
monohydrate, microcrystalline cellulose, croscarmellose sodium,hydroxypropyl cellulose, and magnesium stearate. The tablet coating consists of hypromellose, titanium dioxide, and polyethylene glycol.
 Subjects with hereditary problems of galactose intolerance or Lapp lactase
deficiency or glucose-galactose malabsorption.
 Expected non-compliance to protocol schedule or unable to have regular followup
due to psychological, social, familial or geographic reasons
Prior therapy with dasatinib.
Any investigational agent or any other anti-cancer agent within 14 days prior to
treatment start. Imatinib mesylate may be continued up to 7 days before treatment
start, or, in the presence of rising peripheral blast cells, imatinib may be continued up to 2 days before treatment start. If required for control of peripheral blast cells,hydroxyurea, corticosteroids, 6-mercaptopurine or 6-thioguanine may be given up
to 2 days before treatment start.
Subjects requiring ongoing medications which may:
 Have a known risk of causing QTc prolongation ii) Irreversibly inhibit platelet function, or anticoagulants (Does not apply to low-dose heparin for prophylaxis or to heparin flushes for i.v. lines)
For Cohort #3: Prior chemotherapy, immunotherapy, or radiotherapy for CML
with the exception of hydroxyurea.
Prisoners or subjects who are involuntarily incarcerated
Subjects who are compulsorily detained for treatment of either a psychiatric or
physical (eg, infectious disease) illness"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:35
RBR-5rt76n	Use of adhesive strip compared to physiotherapy in treating shoulder pain	recruiting	Intervention	2011-07-03	<NULL>	<NULL>	11	The Effects of Scapular Taping compared to physical therapy on Electromyographic Muscle Activity in subjects with subacromial impingement symptoms.	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-05-01	Universidade de Pernambuco	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5rt76n	<NULL>	"Inclusion criteria is described as: pain before 150° of active shoulder elevation in any plane, positive Jobe test indicating the possible supraspinatus involvement, positive
Hawkins–Kennedy and Neer test, subjective complaint of difficulty performing activities of daily living. 
All volunteers must be doing sports (handball, volleyball, swimming and judo / jujitsu) for at least two years, with six hours of weekly training."	Subjects will be excluded if they show signs or symptoms of any of the following: neural, cervical or thoracic pathological conditions; or previous surgery of upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-3nm5bv	Effects of physical exercises in lung cancer individuals	recruiting	Intervention	2011-07-06	<NULL>	<NULL>	13	Impact of pulmonary rehabilitation in the incidence of postoperative respiratory complications in pulmonary resection for lung cancer	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2010-01-01	HOSPITAL DE MESSEJANA DR. CARLOS ALBERTO STUDART GOMES - SESA/CE	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-3nm5bv	<NULL>	"Staging of lung cancer among IA, IB, IIA, IIB and IIIA.
Medical Research Council (MRC)dyspnea scale at moderate to severe.
Candidate for pulmonary resection through thoracotomy.
Males and females aged greater than or equal to 38 years and less than or equal to 80 years."	"Severe cardiovascular or other diseases that contraindicate exercise;
Diseases with orthopedic impairments that preclude the exercise."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-7dq5xx	Study of the effect of negative expiratory pressure method generated in the mouth in bus drivers professionals subjects with suspect of obstructive sleep apnea.	recruiting	Observational	2011-07-11	<NULL>	<NULL>	15	Cross-sectional study on efficacy of negative expiratory pressure test proposed as screening for obstructive sleep apnea syndrome among commercial interstate bus drivers	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Nove de Julho - UNINOVE	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7dq5xx	<NULL>	Male interstate professional bus drivers who agree to sign the Informed Consent Term.	"Subjects with ischemic and dilated heart disease;
Subjects with episodes of acute decompensation in the two months prior to the study protocol;
Subjects with primary heart valve disease;
or acute or chronic cardiopulmonary or neuromuscular diseases;
Subjects who have been submitted to recent surgical procedures in the region of the chest wall; or those with a history of stroke, drug users and those who abuse alcohol."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-9k9hhv	Study of sleep, respiratory control during sleep and quality of life in morbidly obese subjects undergoing bariatric surgery.	recruiting	Intervention	2011-07-11	<NULL>	<NULL>	16	Sleep study, respiratory mechanics, chemosensitive response and quality of life in morbidly obese patients undergoing bariatric surgery: A prospective, randomized, controlled	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	<NULL>	Universidade Nove de Julho - UNINOVE	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-9k9hhv	<NULL>	"Grade III morbid obesity (BMI between 40 and 55 kg/m²) or between 35 and 39 kg/m² with comorbidities;
Both gender patients aged 18 to 65 years;
Documented history of conventional weight loss attempts having proven unsuccessful over time;
Agreement to participate in the study through a signed term of informed consent."	"Any medical condition rendering surgery too risk;                                 
Clinically significant or unstable mental health concerns;
Pregnancy, lactation or planned pregnancy within two years of potential surgical treatment;
Smokers (at least 8 weeks prior to surgery), abusive alcohol use and/or drugs use."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-5ypjzb	Bilateral arms function after bilateral training in individuals with severe hemiparesis: a randomised clinical trial	recruiting	Intervention	2011-07-31	<NULL>	<NULL>	19	Bilateral upper limbs function after bilateral training in individuals with severe hemiparesis: a randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade do Estado de Santa Catarina	Nayara Correa Farias	https://ensaiosclinicos.gov.br/rg/RBR-5ypjzb	<NULL>	"Chronic Hemiparesis (at least six months after stroke);  Age over 21 years;
  Severe impairment in upper limb (Fugl-Meyer in the less 30/66);  Understanding simple order"	Patients with other associated neurological diagnosis;  Subjects with orthopedic injuries in the upper bounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-75ddtf	Rehabilitation in patients with carpal tunnel syndrome	recruiting	Intervention	2011-08-09	<NULL>	<NULL>	20	Conservative treatment in patients with carpal tunnel syndrome: randomized and controlled trial study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Universidade de São Paulo	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75ddtf	<NULL>	Patients with clinical and electromyographic diagnosis of non surgical CTS.	Patients with no nerve damage associated with multiple complex lesions, bone or joint injury, the presence of central nervous system injury, or other chronic metabolic and degenerative rheumatic diseases, leprosy and diseases affecting the peripheral nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-26ydc3	Effect of a pharmacotherapeutic management protocol in patients hospitalized with cardiovascular diseases	recruiting	Intervention	2011-10-27	<NULL>	<NULL>	31	Improving Medication Adherence and Clinical Outcomes Following Hospitalization in Chronic Cardiovascular Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-01-07	Alfredo Dias de Oliveira Filho	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-26ydc3	<NULL>	"Aiming maximum inclusiveness we recruited all patients who had a discharge diagnosis
of CVD and who were on antihypertensive medication."	Patients were excluded if they reported already using any tool to improve their adherence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-2dgbbz	Training and reaching in premature infants	recruiting	Intervention	2011-10-30	<NULL>	<NULL>	32	Evaluation of a training on the performance of reaching in late preterm infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de São Carlos (UFSCar)	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-2dgbbz	<NULL>	Infants born between 34 weeks and 36 weeks and 6 days of gestational age (late preterm infants), appropriate for gestational age, with first and fifth minute Apgar Scores greater than 7, with adequate motor performance according to the Alberta Infant Motor Scale (AIMS), without major pre- and perinatal complications, and at maternal care.	Infants who do not attend the evaluations/training in the scheduled period (until 5 days after the infant reaching acquisition) or do not perform reaching movements at the pre-training evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:36
RBR-994xfs	Effects of specific therapies on the masticatory system and on sleep variables  in cerebral palsy patients.	recruiting	Intervention	2011-11-24	<NULL>	<NULL>	36	Randomized, five arm clinical trial to evaluate the effects of neuromuscular electrical stimulation, lasertherapy and ledtherapy on the masticatory system and the impact on sleep variables  in cerebral palsy patients.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-07	UNESP-Universidade EStadual Paulista Juluo de Mesquita Filho/ Faculdade de Odontologia de Sâo José dos Campos	UNINOVE -Universidade Nove de Julho- São Paulo - SP	https://ensaiosclinicos.gov.br/rg/RBR-994xfs	<NULL>	Subjects from both gender, between 7-15 years old with cerebral palsy; present cognitive system partly preserved; sign the consent term.	Have used botulim toxin before 6 month prior the study;have underwent ortodontic treatment prior the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-3p5s66	Physical therapy on quality of life in patients with Urinary Incontinence	recruiting	Intervention	2011-12-06	<NULL>	<NULL>	39	The influence of physiotherapy intervention on quality of life in patients with urinary incontinence	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2010-07-03	Pontifícia Universidade católica do Rio Grande do Sul	Pontifícia Universidade católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3p5s66	<NULL>	Female subjects with a medical diagnosis of urinary incontinence will be included. They will be referred from the Urogynecology outpatient&apos;s clinic of the Hospital São Lucas from the Pontifícia Universidade Católica do Rio Grande do Sul. Previous to their inclusion on the study, all subjects will have signed the free informed consent form.	There will be excluded women that  during the study period perform any additional physical therapy, or initiate any kind of structured and planned physical activity in addition to those provided in the protocol, those with medical conditions that promote disability other than the urinary incontinence, such as severe lung disease, neurological diseases, malignancies, severe cardiac disease or those who have undergone surgery for urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-257zbc	Study of the effect of a new treatment with antibiotic in babies with brochiolitis.	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	42	Using azithromycin to reduce bronchiolitis length of hospital stay in infants.	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2010-09-01	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	Fundação de Amparo a Pesquisa do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-257zbc	<NULL>	Infants younger than 12 months, with diagnosis of acute bronchiolitis and hospitalization for at least 24 hours.	Chronic lung disease, cystic fibrosis, congenital heart diseases and previous use of macrolides.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-6twwh2	Nursing consultation in the monitoring of adults with type 2 diabetes.	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	44	Effect of using the method of case management on glycemic control in people with type 2 diabetes.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-12	Universidade Federal do Paraná	Universidade Estadual do Norte do Paraná.	https://ensaiosclinicos.gov.br/rg/RBR-6twwh2	<NULL>	"Being patient with type 2 diabetes mellitus;
Both sexes;
Age between 18 and 60 years;
Accept the invitation to participate in the survey;
Being a resident of Bandeirantes city."	"People with type 2 diabetes who have psychiatric disorders, which affect the language;
People with type 1 diabetes;
Pregnant women;
Persons who plan to move to another neighborhood that has not attended for the UBS-ESF or PACS, or even moving to another city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-97kdbr	Effect of walk back training on the treadmill in locomotion of elderly with osteoarthritis of knee	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	46	Effect of gait training back on the treadmill in locomotor function of older adults with osteoarthritis of knee	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-30	Universidade do Estado de Santa Catarina	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-97kdbr	<NULL>	Older adults diagnosed with osteoarthritis, male and female, older than 60 years, presence of pain and stiffness of the knee to at least six months for activities in the standing position, joint pain during passive motion, intermittent swelling, radiographic joint degeneration, and who possess a medical certificate allowing physical activity.	Will be excluded individuals who present systemic rheumatic disease, previous surgery of the lower limbs, making use of orthoses for walking, any other condition that would limit or disable the implementation of proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-2tthrr	Effect of the use of body image stimulation in the treatment of ankle sprains in athletes	recruiting	Intervention	2012-01-04	<NULL>	<NULL>	47	Effectiveness of motor imagery in the treatment of ankle sprains in athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2tthrr	<NULL>	Athlete&apos;s soccer with acute ankle sprains, male and female, aged between 16 and 45 years and underwent a medical evaluation prior.	Sprains associated with lower limb bone fracture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:37
RBR-9v9cwf	Interaction between genes of inflammatory mediators and the effects of physical exercise in older women	recruiting	Intervention	2012-01-09	<NULL>	<NULL>	59	Interaction between single nucleotide polymorphisms of the genes of TNF-alpha, IL6, IL10 and brain-derived neurotrophic factor (BDNF) and the effects of physical exercise in older women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-03	Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9v9cwf	<NULL>	Women above the age of 65; community-dwelling	Elderly people with cognitive impairment detectable by the Mini Mental State Examination, acute phase inflammatory disease, tumor growth in the last five years,  current use of immunomodulating medications, amputation or lower limb fracture in the last 6 months, presence of any neurological disease and current participation in an alternative exercise programme.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-74rr6s	PREVER Study: Efficacy of the combination of Chlorthalidone and Amiloride versus placebo in the prevention of hypertension in patients with prehypertension PREVER 1 Study	recruiting	Intervention	2011-03-02	<NULL>	<NULL>	60	PREVER Study: Efficacy of the combination of Chlorthalidone and Amiloride versus placebo in the prevention of hypertension in patients with prehypertension PREVER 1 Study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-02-01	Hospital de Clínicas de Porto Alegre	FINEP	https://ensaiosclinicos.gov.br/rg/RBR-74rr6s	<NULL>	"I. individuals with 30 to 70 years of age 
II. Systolic Arterial Pressure 120-139 mmHg or Diastolic Arterial Pressure 80-89 mmHg;"	"I. Previous diagnosis of hypertension or use of antihypertensive drugs;
II. Allergies to Chlorthalidone Amiloride;
III. Known cardiovascular disease (previous Miocardial Infarction, previous stroke, heart failure or clinical manifestations, for example, current or previous angina, intermittent claudication ...);
IV. Chronic diseases that limit the participation or the prospect of life (such as cancer, rheumatic disease, disability, etc.);
V. Analgesics or anti-inflammatory use for 30 days or more;
VI. Inability to measure blood pressure;
VII. Difficulty in understanding that limits participation in the study;
VIII. IF WOMEN: Pregnant or planning to become pregnant in the next two years;
IX. Patients who have participated in other randomized trials (the last six months);"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-4s7gh3	PREVER Study: Efficacy of Chlorthalidone associated with Amiloride versus  Losartan in reducing blood pressure of patients with hypertension Prever 2 Study	recruiting	Intervention	2011-03-02	<NULL>	<NULL>	61	PREVER Study: Efficacy of Chlorthalidone associated with Amiloride versus  Losartan in reducing blood pressure of patients with hypertension Prever 2 Study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-02-01	Hospital de Clínicas de Porto Alegre	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4s7gh3	<NULL>	"I. Individuals with 40 to 70 years, of both sexes;
II. Diagnosis of Hypertension in stage I, ie, systolic (SBP)  between 140-159 mmHg or diastolic blood pressure (DBP) between 90-99 mmHg"	"I. Chronic diseases that reduce life expectancy or difficulty in understanding the guidelines, which limit the possibility of participation in the study;
II. Refusal to participate or sign an informed consent;
III. Pregnancy or women most likely to become pregnant during the study;
IV. Known allergy to any of the study drugs;
V. Prior diagnosis of secondary hypertension ;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-2m9mgq	Evaluation of masticatory function in adult patients with cerebral palsy	recruiting	Observational	2012-01-25	<NULL>	<NULL>	62	Clinical and electromyographic evaluation of masticatory dynamics in adult patients with cerebral palsy	<NULL>	1, n/a, n/a	1	<NULL>	<NULL>	<NULL>	2011-07-01	Faculdade de Odontologia \ UNESP	Faculdade de Odontologia \ UNESP	https://ensaiosclinicos.gov.br/rg/RBR-2m9mgq	<NULL>	"Origin of the volunteers: Patients from ‘Associação Pró-Saúde para Pacientes com Necessidades Especiais’ - ASPE and Training Program in Dentistry for Persons with Disabilities from Dentistry School of São José dos Campos / UNESP.
Type of cerebral palsy: diparetic, quadriparesis or hemiparesis.
Age: from 18 to 50 years old.
Characteristics of participants: no cognitive deficits, collaborative behavior and without treatment of botulinum toxin at least six months before the study begins.
Concordance of the participants and the legal representative to join the study."	"Origin of the volunteers: originating from  other institutions than DentistrySchoolof  São José dos Campos / UNESP .
Type of cerebral palsy: Any paralysis different than quadriparesis, hemiparesis or diparetic.
Age: not adults.
Characteristics of participants: presentingcognitive deficits, not collaborative behaviorand / or under botulinum toxin treatmtentat least six months before the survey.
Lack of agreement of the participant in this study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-6mbrrk	Evaluation of the effect of the treatment with airway positive pressure device on blood pressure levels of  hypertensive patients with sleep apnea syndrome.	recruiting	Intervention	2012-01-26	<NULL>	<NULL>	65	Efficacy of continuous positive airway pressure on blood pressure control of resistant hypertensive patients with obstructive sleep apnea syndrome.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-07-01	Faculdade de Medicina - Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-6mbrrk	<NULL>	Patients with resistant hypertension and moderate-severe obstructive sleep apnea syndrome	Marked cognitive deficit, non-adherence to anti-hypertensive treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-389mzn	Clinical evaluation and treatment of voice tremor with botulinum toxin and propranolol.	recruiting	Intervention	2012-01-31	<NULL>	<NULL>	68	Clinical evaluation and treatment of voice tremor with botulinum toxin and propranolol.	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2011-04-01	Universidade Federal de São Paulo	Capes	https://ensaiosclinicos.gov.br/rg/RBR-389mzn	<NULL>	presence of vocal tremor to perceptual analysis and larynx; older than 18 years, both sexes	presence of laryngeal spasm during laryngoscopy or auditory perceptual, presence of lesions on laryngoscopy, patients with previous treatment, contraindication to propranolol or botulinum toxin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7yhzym	Pilates versus conventional physical therapy for patients with chronic low back pain	recruiting	Intervention	2012-01-31	<NULL>	<NULL>	72	Comparison between Pilates and conventional physical therapy for treatment of patients with  nonspecific chronic low back pain: randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-06-30	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7yhzym	<NULL>	"Medical diagnosis of chronic low back pain
Aged 18 to 55 years"	"Protrusion of intervertebral disc Scoliosis
Spondylolisthesis 
Previous spine surgery
Radicular symptoms (leg pain, loss of sensation and reflexes)
Inflammatory diseases
Rheumatic diseases
Cancer
Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-7m3d8w	Influence of an exercise session and a period of physical training on the cardiovascular system of patients with intermittent claudication	recruiting	Intervention	2012-02-01	<NULL>	<NULL>	74	Acute and Chronic Cardiovascular Responses to Exercise in Subjects with Intermittent Claudication	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-03-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Ambulatório de Claudicação Intermitente do Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7m3d8w	<NULL>	"Men
Aged between 50 and 80 years
Ankle-brachial index lower than 0.9
Peripheral artery disease - level II
Able to walk on a treadmill for at least 2 min at 3.2 km/h
Absence of obesity
Systolic and diastolic blood pressures lower than 160 and 105 mmHg, respectively 
Absence of bypass surgery or angioplasty for at least one year
Not using beta-blockers, non-dihydropyridine calcium channel antagonists or peripheral vasodilators
Absence of leg amputation
Absence of orthopedic problems that contraindicates walking."	"Presence of complex arrhythmias and/or ischemia during exercise
Fasting glycemia greater than 250mg/dl
Presence of autonomic dysfunction"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:38
RBR-8dfrpt	Influence of periodontal treatment in periodontitis and diabetes control	recruiting	Intervention	2012-02-01	<NULL>	<NULL>	78	Interaction between chronic periodontitis and type II diabetes:  A randomized clinical trial to study the impact of periodontal treatment on severity of both pathologies by clinical, metabolic, immunology and microbiology parameters	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-25	Universidade Federal de Pernambuco	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-8dfrpt	<NULL>	Diagnosis of type 2 diabetes mellitus; aged 35 years old or more; at least 15 teeth present; clinical and radiographic diagnosis of the presence of chronic periodontitis (AAP, 1999); agreing to participate the study.	Periodontal treatment over the past six months; using antibiotics in the last six months; pregnant women; woman breastfeeding; use of anti-inflammatory chronic form, presence of a systemic condition that might interfere in the course of periodontal disease (immune conditions) or systemic complications of Diabetes Mellitus, smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-8nb7xf	A study that evaluates the influence of an exercise program guided and structured combined with sleep hygiene measures on the metabolic changes, sleep disturbances and quality of life in patients with type 2 diabetes.	recruiting	Observational	2012-02-01	<NULL>	<NULL>	79	A Randomized study on the effects of sleep hygiene in glycemic control in patients with type 2 diabetes mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-12-01	UFC- Universidade Federal do Ceará	UFC- Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8nb7xf	<NULL>	"Know diagnosed type 2 diabetes for at least 6 months.
Men and Woman.
Aged between 40 and 60 years.
Sign the consent term."	"Shift workers
Drug abuse
Hospitalization (past 30 days)
Severe comorbities (renal or hepatic impairment, advanced neoplasia, severe heart failure, severe neurological disorder)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-4smr5g	Determinants values of fasting glucose and glycated hemoglobin for the dental complications occurrence in patients with type 2 diabetes mellitus	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	84	Determination of fasting glucose and glycated hemoglobin levels preditives to dental complications occurrence in patients with type 2 diabetes mellitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-05-05	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas - Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4smr5g	<NULL>	"Diabetes patients assisted at the Diabetes Clinic of the Division of Endocrinology, Hospital das Clinicas, Faculty of Medicine of Ribeirao Preto / USP (HC-FMRP/USP), and the DAPE Service (Demystifying Dental Care to Patients with Special Needs) School of Dentistry of Ribeirão Preto / USP (FORP-USP)will participate in this study and nondiabetic individuals assisted at the Faculty of Dentistry of Ribeirão Preto - USP (FORP / USP).
 Selected patients will be diagnosed with type 2 diabetes based on the recommendations of the World Health Organization, with progression of the disease at least 5 years, of both sexes, with no predilection for race, over 18 years. Patients must have indication for periodontal dental treatment and/or surgery."	"Type 2 diabetics patients presenting microvascular and macrovascular complications (diabetic retinopathy with vision loss, diabetic neuropathy, diabetic foot + resulting in amputations, coronary heart disease, peripheral arterial disease, cerebrovascular disease, nephropathy developed with the need for dialysis, except for periodontal disease ) patients with systemic or local infectious diseases beyond the mouth, showing malignancy or any other type of disease and drugs that result in immunosuppression, smoking, individuals who have made use of systemic antibiotics in the three months preceding the study.
 Are also excluded patients with diabetes have changes in dosage of medication taken within 3 months prior to dental care.
 The clinical examination will exclude individuals presenting PSR 1 or 2, presenting less than 6 mouth dental elements, individuals with lesions in the oral mucosa, and those who disagree on signing the informed consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-3x64sp	Pilates exercises and breathing in the elderly	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	86	Influence of exercise based on the principles of Pilates respiratory muscle performance in older	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-03-28	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3x64sp	<NULL>	For inclusion in the sample, the subject should be female and must be between 65 and 80 years; may not have neurological and/or musculoskeletal disorders that preclude the exercises; can not use any assistive mobility device and must present cognitive state compatible with the education evaluated by the Mini Mental State Examination (MMSE).	Will be excluded the elderly woman who refuses to participate in the research, have pain complaints, a hypertensive crisis or syncope during the course of training or miss two training sessions planned.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-6nz2cg	Attention effects on handicap person&apos;s movement	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	87	The effects of attention directed to movement parameters on motor behavior of handicap persons	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-11-08	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6nz2cg	<NULL>	"Healthy adults:  history of no muscular injury or not healed on dominant upper limb; no geometrical alterations on dominant upper limb; no reduction on normal joint amplitude of dominant upper limb; do not be overweight or obese.

Handicap adults: to have a minimum of 1yr of medular injury; Level A or B of American Spinal Injury Association (ASIA); realese from physical therapy treatment for a maximum of 2yr; trunk balance sufficient to sustain upper limbs at 90 degrees angle for at least 30sec.; do not have history of muscular injury or not healed on dominant upper limb; do not have geometrical alterations on dominant upper limb; do not have reduction on normal joint amplitude of dominant upper limb; ulcera pressure; urinary infections; depression; do not be overweight or obese."	"Healthy adults:  to have history of muscular injury or not healed on dominant upper limb; geometrical alterations on dominant upper limb; reduction on normal joint amplitude of dominant upper limb; overweight or obesity.

Handicap adults: to have more than 1yr of medular injury; Level C or higher of American Spinal Injury Association (ASIA); realese from physical therapy treatment for more than 2yr; trunk balance insufficient to sustain upper limbs at 90 degrees angle for at least 30sec.; have history of muscular injury not healed or treated on dominant upper limb; geometrical alterations on dominant upper limb; reduction on normal joint amplitude of dominant upper limb; ulcera pressure; urinary infections; depression; overweight or obesity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-4njyw9	Effects of fish oil supplementation  on pre diabetes in patients with chronic hepatitis C.	recruiting	Intervention	2012-06-05	<NULL>	<NULL>	94	Effects of omega 3 fatty acids supplementation  on insulin resistance in patients with chronic hepatitis C.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-05	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4njyw9	<NULL>	Adults (age &gt; 18 years) diagnosed with chronic hepatitis C (genotype I); either non responders or naive patients; alcohol consumption &lt; 40g/dia; HOMA index &gt; 2.5; Signature of term consent	Diabetics or those using drugs to alleviate insulin resistance, co-infected (HIV or HBV), hepatitis with autoimmune or use of antiviral treatment (interferon and ribavirin), decompensated liver disease or patients with hepatocellular carcinoma; With other neoplasias; Patients with chronic renal failure or decompensated heart failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7tmkv9	Italian Study on Sleep and Heart Failure	recruiting	Observational	2012-12-11	<NULL>	<NULL>	98	Italian Multicenter Project Sleep and Heart Failure	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2012-08-01	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-7tmkv9	<NULL>	Patients with heart failure who agree to participate in the study; both gender; age between 19 and 90 years; cognitive level sufficient to understand the procedures and follow the instructions; stable clinical conditions for at least four weeks and optimized medical therapy; assigned consent form.&quot;	Individuals with HIV; renal failure with the calculation of filtered under 30ml/minutes; malignant neoplasm; abuse of alcohol and or drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-6gdyvz	Effects of Resistance Training on Cardiovascular Risk Factors in Middle Aged Women	recruiting	Intervention	2012-12-12	<NULL>	<NULL>	99	Effects of Different Models of Undulating Periodization of Resistance Training on Cardiovascular Risk Parameters, Body Composition, Muscle Strength and Lifespam in Premenopausal Women with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-04-10	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6gdyvz	<NULL>	To be pre-menopausal aged between 18-49 years and no regular practice of exercise in the previous 12 months	Use of drugs that could affect cardiovascular response to exercise and presence of any disease that would compromise their health during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-9tcn2x	Electroacupuncture and Manual Acupuncture in Patients With Knee Osteoarthritis	recruiting	Intervention	2012-11-29	<NULL>	<NULL>	101	Electroacupuncture and Manual Acupuncture in Patients With Knee Osteoarthritis: Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-01	Universidade Cidade de São Paulo	Ralph Plaster	https://ensaiosclinicos.gov.br/rg/RBR-9tcn2x	<NULL>	Pacients with knee pain, with minimal intensity 2 in visual analogic scale (0-10); Radiographic exam showing knee ostearthritis degree II, III or IV accordingly Kelgren and Lawrence classification	Patients with a history of cancer; dementia; neurological deficits (sensory or motor); cardiac pacemaker; decompensated type I diabetes; uncontrolled systemic arterial hypertension; morbid obesity; currently taking antidepressants; anti-inflammatory steroids in the last six months; tranquilizers; and that are currently under physiotherapy sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-3s9m65	The Importance of Physical Exercise in Balance and Gait With or Without Another Task in The Elderly	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	103	The Influence of Physical Exercise on Postural Control and Gait pattern Associated or not to The Dual-task	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-12	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	Hospital de Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3s9m65	<NULL>	Healthy older, between 60 and 80 years, living in the community	Presence of cardiovascular, neurological or vestibular diseases, presence of musculoskeletal problems that interferes with static or dynamic balance, peripheral neuropathies, use of medication for central nervous system, mini-mental State Examination (MMSE) score less than 23	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-5yc53k	Influence of strength training performed alone or associated with functional training on the cardiovascular system of elderly patients with Parkinson Disease.	recruiting	Intervention	2012-06-19	<NULL>	<NULL>	116	Effect of resistance training performed alone or associated with functional training on cardiovascular function and autonomic modulation in elderly patients with Parkinson Disease.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-27	Escola de Educação Física e Esporte da Universidade de São Paulo	Centro de Estudos em Psicobiologia e Exercício da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5yc53k	<NULL>	"45 Individuals with Parkinson&apos;s disease in stages from I to III assessed by the Hoehn and Yahr scale
15 Elderly subjects without Parkinson
Both genders
Aged above 60 years
Sedentary
Normotensive (systolic and diastolic blood pressure less than 140 and 90 mmHg, respectively)
No cardiovascular diseases or muscle-skeletal disorders
Not using medications that alter cardiovascular parameters, except in medications for treatment of Parkinson&apos;s disease"	Presence of complex arrhythmias and/or ischemia during exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:42
RBR-35rp8x	Training and reaching in infants	recruiting	Intervention	2012-05-27	<NULL>	<NULL>	123	Influence of training on reaching ability in infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-08-01	Federal University of São Carlos	Federal University of São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-35rp8x	<NULL>	To meet the eligibility criteria, infants had a birth weight between percentiles 10 and 90 on the growth curve, Apgar scores greater than or equal to seven in the first and fifth minutes, adequate motor performance according to the Alberta Infant Motor Scale (AIMS), were in maternal care and not in day care centers.	Infants who are born with gestational age less than 37 weeks, low birth weight (below 2500g), with Apgar score below seven in the first and fifth minutes of life and those who submit, congenital central nervous system, signs neurological, musculoskeletal changes, diagnosis of genetic syndromes or symptoms of withdrawal symptoms associated with maternal report of abuse of alcohol and drugs, congenital infections, sensory deficits, cardiopulmonary difficulties or whose mothers have submitted episode of eclampsia or preeclampsia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-7v2vvt	The use of carbon dioxide (CO2) as a contrast medium for performing endovascular procedures	recruiting	Intervention	2012-05-11	<NULL>	<NULL>	127	The use of carbon dioxide (CO2) as a contrast medium for performing endovascular procedures	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Hospital Israelita Albert Einstein	Hospital Municipal M'boi Mirim - Dr. Moysés Deutsch	https://ensaiosclinicos.gov.br/rg/RBR-7v2vvt	<NULL>	Patients with critical lower limb ischemia resulting from arterial disease morphology TASC A or B  or abdominal aortic aneurysms with an indication for the correction ; Agreement and signing the informed consent.	Contraindications to any of the types of procedures either by the technique used, type of contrast or medical reasons.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-4tbd4p	Resistance training in clinical, inflammatory process control in patients with moderate, severe and difficult control asthma.	recruiting	Intervention	2012-05-11	<NULL>	<NULL>	129	Resistance training in clinical, inflammatory process control in patients with moderate, severe and difficult control asthma.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-15	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-4tbd4p	<NULL>	"In medical treatment-outpatient for at least six months;
Clinical picture stable for three months; Optimized drug therapy."	"Heart disease associated with pulmonary disease; 
Musculoskeletal pathology that may interfere with the conduct of reviews or exercises;
Pulmonary hypertension;
Difficulty to learn."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-25tcrt	Effects of electrical stimulation and ventilatory muscle training in patients with kidney disease on hemodialysis	recruiting	Intervention	2012-05-01	<NULL>	<NULL>	136	Effects of functional electrical stimulation and inspiratory muscle training on quality of life and functional capacity of patients with end-stage renal disease on hemodialysis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-10	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Irmandade da Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-25tcrt	<NULL>	Patients with ESRD undergoing hemodialysis more than 3 months; Urea clearance during hemodialysis (Kt / V) &gt; 1.2	Patients with recent stroke, disabling osteoarticular or musculoskeletal disease, uncontrolled hypertension (SBP &gt; 230mmHg and DBP &gt; 120 mmHg), heart failure class III or IV according to the NYHA or decompensated, uncontrolled diabetes (glicaemia &gt; 300 mg / dL), unstable angina, fever and / or infectious disease, acute respiratory failure; recent acute myocardial infarction (2 months), active smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:41
RBR-67zvt5	Homeopathic medicines as complementary treatment of cocaine dependence.	recruiting	Intervention	2012-05-01	<NULL>	<NULL>	139	Fifty-millesimal potencies of Opium and Erythroxylum coca as complementary treatment of cocaine dependence: pilot, randomized, placebo controlled, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-01-12	Universidade Federal de São Paulo	Centro de Referência de Álcool, Tabaco e Outras Drogas da Secretaria de Estado da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-67zvt5	<NULL>	"Patients between 18 and 65 years, who met DSM-IV TR criteria for cocaine dependence 
Capacity and willingness to give informed consent and to comply with study procedures
were also required."	Disabling clinical or psychiatric diseases that would hinder regular participation in the study; acupunture or homeopathic  treatment simultaneously to the study; simultaneous participation in another clinical trial; concomitant pregnancy; patients who are assumed to have a linguistic, intellectual or any other reason for not understanding the meaning of the clinical trial and for not complying with the necessary study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-3jdm6d	Analysis of the cardiac frequency and oxygenation during sleep in patients with the Obstructive Sleep Apnea Syndrome	recruiting	Observational	2012-04-24	<NULL>	<NULL>	141	Study of autonomic cardiac behavior and oxygen saturation during sleep in patients with the Obstructive Sleep Apnea Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2011-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3jdm6d	<NULL>	"Individuals of both sexes;
Aged 18-80 years;
With suspicion diagnosis of obstructive sleep apnea;
Who underwent full polysomnography in sleep Institute of San Carlos;
Technical data could be analyzed;"	Patients who underwent polysomnography, but whose data are not technically acceptable.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-7b5ycz	Evaluation of dressing for central venous catheter	recruiting	Intervention	2012-04-26	<NULL>	<NULL>	143	Evaluation of the effectiveness of the chlorhexidine antimicrobial dressing for central venous catheter	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-10-17	Universidade Federal do Paraná	3M do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7b5ycz	<NULL>	"Over 18 years;
Hospitalization in the Intensive Care Unit (ICU) or Semi Intensive (CTSI) Adult;
In the first use of central venous catheter (CVC) for short stay less than 24 hours;
Signing the consent form;
No known sensitivity to materials of the dressings."	"Refusal by the patient or explained by the family to participate in the research;
By shaving blade at the site of catheter insertion prior to puncture;
Sweating or bleeding from the orifice of the catheter;
Temperature above 38 ° C during puncture of the catheter."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-9jjj2n	Impact of exercise in ovseweight nondialyis dependent chronic kidney disease patients.	recruiting	Intervention	2012-04-09	<NULL>	<NULL>	144	Home-based vs in center aerobic exercise: impact on functional capacity, nutritional status and cardiometabolic parameters in overweight nondialysis dependent chronic kidney disease patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-01-05	Universidade Federal de São Paulo	Fundação Oswaldo Ramos	https://ensaiosclinicos.gov.br/rg/RBR-9jjj2n	<NULL>	"Sedentary individuals with chronic kidney disease stages 3 or 4 disease;
Both genders;
Age between 30 and 65 years;
Overweight (BMI&gt; 25 kg/m2;
With a negative stress test."	"Patients with chronic obstructive pulmonary disease, class IV heart failure, myocardial infarction within the last 6 months, decompensated hypertension (systolic blood pressure&gt; 180 mmHg or diastolic&gt; 110 mmHg in the last 6 months), uncontrolled cardiac arrhythmia, decompensated diabetes mellitus (glycated hemoglobin&gt; 8.0%), unstable angina, infectious processes in the last 3 weeks;
Use of erythropoietin or beta-blocker medication or with hemoglobin &lt;11g/L."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6z42q3	Evaluation of a type of therapy for the treatment of vaginal pain during intercourse.	recruiting	Intervention	2012-04-11	<NULL>	<NULL>	146	Electrical stimulation of the pelvic floor in the treatment of women with chronic vulvar pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-02	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	Faculdade de Ciências Médicas - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6z42q3	<NULL>	"Women with vulvodynia symptons, for, at least 6 months
 Women with positive test for vulvodynia 
 Women willing to participate and to accept and sign voluntarily, the consent term"	"Women who use intrauterine device
 Pregnancy
 Women who use pacemakers
 Women who have some sort of metal implant in the region of the lumbar spine or hip
 Women who have neoplasic diseases
 Women with acute infectious process in the vulvar region
 Chronic Immunosuppression
 Deformity of the spine or pelvis
 Genital ulcer
 Women on medications that may cause mucositis (eg prolonged use of antibiotics, immunomodulators, chemotherapeutics)
 Women with systemic or acute allergic framework (localized)
 Women who are known to have chronic degenerative disease (eg Acquired immunodeficiency syndrome, renal transplant, lupus, tuberculosis)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-6c2k3m	Evaluation of two types of implants installed in the jaw	recruiting	Intervention	2012-04-16	<NULL>	<NULL>	147	A comparative study of marginal bone variation around Titanium-13Zirconium and versus Titanium Grade IV.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c2k3m	<NULL>	"To sign voluntary informed consent for using his/her data;
At least 18 years-old; 
Posterior edentulous areas that needed at least 2 implants in the maxilla, or 2 implants in the mandible 
To have a posterior area to receive one narrow implant diameter at least 8 weeks to implant installation;
5 mm of ridge width and 8 mm of lengh; These implants had to receive one single-crown rehabilitation and to have a antagonist tooth
1 year of follow up."	"Presence of sistemic problems, ex. diabetes
Use of any drug that could affect bone metabolism (biphosphonates);
Tobacco abuse (&gt; 10 cigarettes/day);
Presence of immunocompromising conditions (HIV-positive, AIDS, or under therapy with immunosuppressive drugs);
Disability that interferes with the ability of a suitable cleaning;
History of radiotherapy of the head/neck region . 
Pregnancy or lactating;
Condition or circumstance that may lead patients to abandon the study;
Presence of untreated periodontitis;
Soft and/or hard tissues alterations;
Previous bone augmentation procedure in the same place to fixture installation; 
Presence of parafunctional habits;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-969prp	Effect of a Pilates exercise program on flexibility, muscle performance and balance of elderly women.	recruiting	Intervention	2012-03-07	<NULL>	<NULL>	155	Effect of an exercise program based on the principles of the Pilates method in flexibility, muscle performance and balance of elderly women: a randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-31	Universidade Federal do Rio Grande do Norte (UFRN)	Universidade Federal do Rio Grande do Norte (UFRN)	https://ensaiosclinicos.gov.br/rg/RBR-969prp	<NULL>	Female; aged 65 to 80 years; absence of neurological and muscle - skeletal disease that preventing the holding of the exercises, as well as the use of a wheelchair for mobility; cognitive status compatible with schooling assessed by the Mini Mental State Examination (MMSE).	Refusal to participate in the survey; pain complaints during the course of training; unexcused absence and without replacement in 10% of training provided.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:40
RBR-83mmq5	Effect of mirror therapy associated with functional tasks in arm function after stroke	recruiting	Intervention	2011-07-07	<NULL>	<NULL>	157	Effect of mirror therapy associated with functional tasks in arm function after stroke: a randomised clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2011-03-01	Universidade do Estado de Santa Catarina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-83mmq5	<NULL>	This will include individuals who suffered Stroke proven by CT scan or MRI for at least 6 months (chronic phase). Those with motor recovery level &gt; 30 (mild or moderate impairment) in the upper extremity section of the Fugl-Meyer motor assessment, scores on the modified Ashworth scale 2 or less for muscle groups evaluated (horizontal shoulder adductors, elbow flexors and wrist and finger flexors) and those able accomplish a task of handling rough (reach and grab a cylindrical object).	Will be excluded individuals with other neurological diseases, orthopedic problems in the upper limbs that interfere with the function of these, significant visual impairment not correctable, aphasia or difficulty to understanding simple tasks (eg reach and grasp a bottle); visual hemineglect verified through the Bells Test; members of other research or therapy involving the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-7cb9yc	Effects of two physiotherapy approaches in patients with low back pain	recruiting	Intervention	2011-11-06	<NULL>	<NULL>	158	Immediate effects of specific or inespecific spinal manipulation in patients with chronic low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-11-07	Universidade Cidade de São Paulo	Bandagens Plus	https://ensaiosclinicos.gov.br/rg/RBR-7cb9yc	<NULL>	We will include patients who will be seeking care for chronic low back pain as well as patients with chronic low back pain from the community with a pain intensity level of at least 3 points on a 0-10 Pain Numerical Rating Scale.	Patients with any contra-indication for manual therapy will be excluded (i.e. lumbar stenosis, spinal fractures, cancer, acute infections, lumbar osteoporosis, acute rheumatic conditions, any bleeding diseases, spinal tuberculosis, and deep venous trombosis).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-2z9xyb	Use of citrate content dialysate in patients on hemodialysis	recruiting	Intervention	2012-02-13	<NULL>	<NULL>	160	Effects of the use of citrate content dialysate on the extracorporeal anticoagulation in maintenance hemodialysis	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2011-07-01	Divisão de Nefrologia da Faculdade de Medicina da Universidade Federal Fluminense	CDR- Clínica de Doenças Renais	https://ensaiosclinicos.gov.br/rg/RBR-2z9xyb	<NULL>	Patients older than 18 years of age, both genders, on maintenance hemodialysis, without major comorbidities.	"Prescription of hemodialysis shorter than 3h 30 min.
Use of oral anticoagulant.
Use of temporary double lumen catheter.
Awating for living donor kidney transplant.
Refuse to participate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:39
RBR-237wbg	Usefulness of Complete Blood Count and Ferritin Measurement in the Anemia Diagnosis in Pregnancy	recruiting	Intervention	2013-01-03	<NULL>	<NULL>	164	Accuracy of Erythrocyte Indices and Serum Ferritin on Diagnosis of Iron-Deficiency Anemia in Pregnant Women: A Phase III Validation Study of Diagnostic Tests	<NULL>	3, n/a, open	3	<NULL>	<NULL>	<NULL>	2011-08-10	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-237wbg	<NULL>	Hemoglobin concentration at least 0.7 and below 11.0 g/dL. Gestational age between 12 and 32 weeks of pregnancy. Low-risk pregnancy.	Hipersensibility or intolerability to ferros sulfate. Mental disease that precludes to understand the intervention. Unknowing the gestacional age. Another cause of anemia: sickel cell disease, talassemia, spherocytosis, autoimmune hemolytic anemia, leukemias,  anemia of crônic disease. Sistemic infeccious diseases: human immunedeficiency virus, siphilis, urinary infeccion, leucocytosis. Tobacco, alcohol or other drugs use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-9wz5fc	Effect of Lifestyle Modification on the Risk Factors for Heart Disease	recruiting	Intervention	2013-01-04	<NULL>	<NULL>	165	Effect of Different Lifestyle Interventions on Metabolic Syndrome: Physical, Metabolic and Behavioral Aspects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-07-10	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9wz5fc	<NULL>	Men and women between 30 and 59 years of age with an abdominal circumference higher than 88 cm for women and higher than 102 cm for men and two (02) or more of the following findings:Blood pressure: systolic equal or higher than 130 mmHg and diastolic equal or higher than 85 mmHg; fasting glucose: equal or higher than  100 mg/dl; triglycerides:equal or higher than  150 mg/dl; HDL cholesterol less than 40 mg/dl for men and less than50 mg/dl for women.	Absolute contraindication to physical activity for musculoskeletal problems, neurological, vascular events (intermittent claudication), lung and heart; Presence of a diagnosis of severe psychiatric disorders and / or presence of significant cognitive impairment assessed by the team through the Mini-Mental State Examination; Difficult to contact and inability to return and follow-up, not available to participate in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-9x8ssz	Influence of two interventions for temporomandibular disorders on the eletric activity of the masticatory muscles and balance.	recruiting	Intervention	2012-03-07	<NULL>	<NULL>	167	Influence of the inespecifc mobilization and the massotherapy on the eletromiographic sign of masticatory muscles and the static balance in individuals with temporomandibular disorders. Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-10-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-9x8ssz	<NULL>	Age: 18 to 50 years old. Diagnosed with temporomandibular joint disorder. Complete Dentition (except for the 3rd molars).	Dental protesis. Open and/or Crossbite. Mandibular prognatism or retrognatism. Neurological Disturbance. In Physioterapic or odontologic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-8n4hg2	Effects of Interferential Therapy on the Mechanisms of Pain in Chronic Low Back Pain Without a Specific Cause	recruiting	Intervention	2013-01-05	<NULL>	<NULL>	168	Effects of Carrier Frequency of Interferential Current on Modulation of Pain and Central Hypersensitivity in Patients with Nonspecific Chronic Low Back Pain: Randomized Controlled Trial	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2013-02-01	Universidade Cidade de São Paulo	Universidade Cidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8n4hg2	<NULL>	Patients presenting nonspecific low back pain for at least 3 months and with at least 3 of pain intensity in verbal numerical pain scale reported according to how they felt in the last 7 days, aged between 18 and 80 years, both genders	Patients with serious spinal diseases, such as fractures, tumors and inflammatory diseases such as ankylosing spondylitis, spinal root conditions confirmed by neurological tests (spondylolisthesis and disc herniation with neurological, narrowing spinal canal and others). Severe cardiorespiratory disease. Neurologial diseases. Pregnancy. Infection in the site of the current application. Cancer. Cardiac pacemaker. Skin lesions at the site of the current application. Alterations in sensibility and allergy in the region of electrodes placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-6hp5h9	Effect of Balance Training in Older Adults	recruiting	Intervention	2013-01-15	<NULL>	<NULL>	169	Effect of a Perturbation-based Balance Training Program on the Reactive Neuromuscular Control in Older Adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-11-15	Universidade Estadual do Centro-Oeste	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6hp5h9	<NULL>	Healthy older, between 65 and 80 years, living in the community.	Presence of cardiovascular, neurological or vestibular diseases. Presence of musculoskeletal problems that interferes with static or dynamic balance. Peripheral neuropathies. Use of medication for central nervous system. Mini-mental State Examination (MMSE) score less than 19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-7x429s	Effects of Cardiac Rehabilitation and Respiratory Capacity and Physical Behavior of Oxygen Consumption in Cardiac Patients	recruiting	Intervention	2013-03-05	<NULL>	<NULL>	173	Effects of Cardiopulmonary Rehabilitation on Exercise Tolerance Time (Tlim) and Oxygen Uptake Kinetics in Ischemic Heart Disease	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-01	Hospital do Coração - HCor - Instituto de Ensino e Pesquisa (I.E.P.)	Comitê de Ética em Pesquisa da  Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7x429s	<NULL>	Patients with ischemic cardiomyopathy with an ejection fraction of the left ventricle than or equal to 35% of both sexes. The minimum age of 18 years and maximum 90 years.	Functional limitations not related to the cardiovascular system. Such as disabling lung diseases and tumors of advanced degree.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-6xsb5h	The Effect of Laser Therapy After Surgery	recruiting	Intervention	2013-03-19	<NULL>	<NULL>	175	The Effect of Low Level Laser Therapy in the Modulation of the Inflammatory Process After Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6xsb5h	<NULL>	Patients who need to perform removal of impacted third molars and to accept part of the study as informed consent and informed.	Systemic diseases, chronic pain or neurological and psychiatric disorders. Being a smoker. Being using anti-inflammatories, analgesics or bisphosphonates in the past 15 days have provided the framework of pericoronitis in the last month. Being pregnant. Being  breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:43
RBR-9b5dh7	Effects of Stimulation Transcranial Direct Current by Associated Gait Training and Mobility Functionality About Children with Cerebral Palsy	Recruiting	Intervention	2013-04-18	<NULL>	<NULL>	179	Effects of Stimulation Transcranial Direct Current by Associated Gait Training and Mobility Functionality About Children with Cerebral Palsy: Clinical Trial Randomized Controlled, Double Blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Node de Julho	Centro de Neurocirurgia Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-9b5dh7	<NULL>	Children with cerebral palsy. Age between 4 and 12 years. Absence of cognitive or visual impairment that could compromise the performance of the tasks. Levels I, II and III of the Gross Motor Functional. Classification System (GMFCS). Functional ambulation for at least 12 months.	Orthopedic surgical procedures or neuromuscular block in the 12 months prior to the training sessions. Presence of orthopedic deformities with surgical indications.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-4rjwrx	Training and Manual Behavior in Premature Infants	Recruiting	Intervention	2013-04-25	<NULL>	<NULL>	182	Effects of Specific Training on the Ability of Reaching in Preterm Infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-11-20	Universidade Federal de São Carlos	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-4rjwrx	<NULL>	Infants born below 37 weeks considered low risk for brain injury, with Apgar Scores of greater than 7, without major pre- and perinatal complications, and at maternal care.	Infants considered high risk, whose medical records report the occurrence of: anoxia, signs of neurological impairment (eg, hypoxic-ischemic encephalopathy grades I, II and III, intracranial hemorrhage, and neonatal seizures), congenital malformations (eg, anencephaly, spina bifida, acondroplasias, microencephaly), genetic syndromes (eg, Down syndrome and chromosomal deletion), sensory changes (visual and auditory), difficulties cardiorespiratory, orthopedic impairment and / or musculoskeletal,  hyperbilirubinemia. For the selection or non-inclusion of infants in the studies according to the risk factors described above, the medical records will be taken as a reference to obtain such information, as well as prompted the collaboration of neonatologists and pediatricians selection of sites for confirmations and questions to resolve.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-8mx5g6	Influence of Captopril use on Blood Pressure Response Measured After a Single Bout of Strength Exercise in Men with High Blood Pressure	Recruiting	Intervention	2011-07-03	<NULL>	<NULL>	193	Effect of Captopril use on Blood Pressure Response After a Single Bout of Resistance Exercise in Hypertensive Men	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2011-07-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-8mx5g6	<NULL>	Men. Aged between 30 and 60 years. Non smokers. Physically inactives (did not perform physical activity more than twice a week). Normotensives and hypertensives will form different groups. Hypertensives should not have end organ damage or secondary causes of hypertension according to the diagnotic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, USP.	Subjects with obesity (body mass index equal or greater than 30 kg/m2). Subjects with diabetes (fasting glycemia equal or greater than 126 mg/dl). Subjects with cardiac diseases (previous diagnosis or alteration on resting or exercise ECG). Subjects who do not tolerate the study medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-2jtbyw	Evaluation of Preoperative Physiotherapy Influence on Postoperative Pulmonary Function of Megaesophagus Surgery	Recruiting	Intervention	2013-06-11	<NULL>	<NULL>	199	Evaluation of A Preoperative Physiotherapeutic Program Influence on Postoperative Pulmonary Function of Megaesophagus Correction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-01-01	Universidade Federal do Triângulo Mineiro	Fundação Pio XII - Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-2jtbyw	<NULL>	Patients diagnosed with achalasia grades III and IV. Patients with resectable esophageal cancer. Age greater than 18 and less than or equal to 75.	Patients who are operated in a period of less than two weeks after the initial assessment. Patients who do not understand the proposed treatment or who refuse to sign the Instrument of Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-3vwfjs	The Use of Topiramate in the Crack Addiction	Recruiting	Intervention	2013-06-13	<NULL>	<NULL>	200	The Use of Topiramate in the Crack Addiction	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2013-02-20	Universidade Federal do Tocantins	Secretaria Municipal da Saúde de Palmas	https://ensaiosclinicos.gov.br/rg/RBR-3vwfjs	<NULL>	Exclusively dependence of crack cocaine. Male gender. Aged between 18-50 years.	Neurological diseases and serious mental disorder. Volunteers already under use of drug therapy for addictions to the crack cocaine. Of multiple drugs users, substance dependents addition to the crack cocaine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-38fknk	Different Techniques for Lung Ventilation During Cardiac Surgeries	Recruiting	Intervention	2013-07-03	<NULL>	<NULL>	202	Assessment Alveolar Recruiting During Heart Surgeries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-05-15	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-38fknk	<NULL>	Age between 19 and 90 years. Ambos sexes. Cirurgia elective coronary artery bypass grafting with or without associated procedures. Surgery of exchange and valvuloplasty. Cirurgia of aneurysms of the ascending aorta and aortic arch. Pacientes who agreed to participate in the study by signing the consent form.	Age less than 19 years or greater than 91 years. Urgent surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:44
RBR-4fw87f	Effects of Patellar Taping in Subjects with Knee Pain	Recruiting	Intervention	2013-07-15	<NULL>	<NULL>	211	Influence of Patellar Taping on Baropodometric Characteristics of Subjects with Patellofemoral Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-09-18	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4fw87f	<NULL>	Women aged between 18 and 35 years, with pain in the anterior knee insidious onset, no history of trauma in the region. Duration of symptoms for longer than 12 weeks and triggered by  perform two of the following activities: up or down stairs, squatting, sitting for long stay; while practicing physical activity. On physical examination must present pain in two of four tests: isometric contraction of the quadriceps, squats, palpation of the medial or lateral patellar and step down. To compose the control group will be selected women without musculoskeletal symptoms in the lower limb.	Women who underwent physical therapy for the lumbar spine, pelvis and lower limbs in the last 6 months prior to collection. With a history of neurological diseases and surgery of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:45
RBR-2cxrpp	Effect of Two Kinds of Therapy on Women with Patellofemoral Pain Syndrome	Recruiting	Intervention	2013-07-30	<NULL>	<NULL>	217	Effects of Lumbo-pelvic Stabilization Training on Women with Patellofemoral Pain Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-06-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2cxrpp	<NULL>	Women agend between 18 and 30 years old, anterior or retropatellar knee pain during at least two of the folling activities: ascending/descending stairs, squating, running, jumping and prolonged sitting, insidious onset of the symptoms being unrelated to a traumatic incident and persistent for at least 8 weeks, presence of pain on palpation of the patellar facets, usual pain in the last week of at least 3cm in the Visual Analogue Scale (VAS) of 10cm.	Signs or symptoms of meniscal disorders, cruciate or collateral ligament involvement, tenderness over the patellar tendon, iliotibial band, or pes anserinus tendons, sign of patellar apprehension, Osgood-Schlatter or Sinding-Larsen-Johansson syndromes, hip or lumbar referred pain, history of patellar dislocation, evidence of knee joint effusion, previous surgery on the knee joint.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-6tc7mj	Evaluation of Knee Alignment	Recruiting	Intervention	2013-08-05	<NULL>	<NULL>	219	Biomechanics of Lower Limbs Valuation Pre and Post-treatment of Individuals with Anterior Knee Pain. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-12-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6tc7mj	<NULL>	Female, aged between 18 and 28 years. Knee pain for at least 6 months. Fitness for muscle strengthening exercises and stretches.	Individuals with a history of musculoskeletal injuries in lower limbs (fractures or ligament injuries in lower limbs).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-55jf6q	Efficacy and Safety Evaluation of HCPA-1 Silicone Stent in the Treatment of Central Airway Obstructions.	Recruiting	Intervention	2013-08-08	<NULL>	<NULL>	224	Efficacy and Safety Evaluation of  Silicone Stent in the Treatment of Central Airway Obstructions.	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2011-04-01	Ministério da Saúde	Hospital de Clinica de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-55jf6q	<NULL>	Consent to participate in the study by signing (by the patient or family / legal guardian when aplicable) of the Informed Consent Form; 18 years old or more;  clinically significant stenosis (symptomatic or about to become symptomatic) in the trachea, main bronchus or intermediate bronchus, which can be treated after a stente implant.	Clinical or absolute anesthesic contraindication of the rigid bronchoscopy under general anesthesia;constitutional or acquired anatomic limitations that prevent the rigid bronchoscopy;another indication of exclusive preferential treatment modality for stenosis (surgery, radiotherapy, chemotherapy, other).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-78tbws	Effect of hydration on the mechanisms responsible for changes in blood pressure  after one session of aerobic exercise.	Recruiting	Intervention	2013-08-13	<NULL>	<NULL>	226	Effect of hydration on blood pressure response after exercise and its mechanisms.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2010-01-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78tbws	<NULL>	"Healthy men
Sedentary
Aged 18 to 35 years"	"Individuals trained
Hypertension (systolic and diastolic blood pressures greater than or iqual to 130/85 mmHg)
Obesity (body mass index greater than or equal to 30kg/m2)
Smokers
Diabetes (fasting glucose greater than or equal to 126 mg / dl)
Heart diseases (previous diagnosis or change in rest or exercise ECG)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-2t37vy	Validation of Jebsen-Taylor Hand Function Test for Muscular Dystrophy	Recruiting	Intervention	2013-08-19	<NULL>	<NULL>	230	Validation of Portuguese Version of Jebsen-Taylor Hand Function Test for Patients with Muscular Dystrophy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2t37vy	<NULL>	"Individuals with Duchenne Muscular Dystrophies types, Waistlines, Congenital, Fascioescapuloumeral and Myotonic with diagnosis confirmed
by immunohistochemical and / or muscle biopsy, which have seven years of age or older and who were monitored
Clinical Brazilian Association of Muscular Dystrophy, individuals who underwent surgical procedures in upper and / or spine, concordance in research participation by signing the consent form"	Difficulty understanding simple verbal commands, deficits-visual and / or auditory preventing the implementation of the research protocol, presence of associated neurological disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:46
RBR-3ss6zt	Comparation of Physiotherapu Approach Using Weights and Elastic Bands on Respiratory Function	Recruiting	Intervention	2013-08-21	<NULL>	<NULL>	233	Comparation of Proprioceptive Neuromuscular Facilitation with Resistive Exercise of Fixed Load and Elastic Load on Respiratory Function	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-02-02	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3ss6zt	<NULL>	Normotensive, aged 18-25 years, not smoking, right-handed according to the Inventory of the Edinburgh Handedness, sedentary.	Underweight and obese according to body mass index, heart disease, lung disease, musculoskeletal disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-9zmfs9	Evaluation of Green Propolis as a oral Anti-inflammatory Drug	Recruiting	Intervention	2013-08-21	<NULL>	<NULL>	234	Evaluation of Clinical Safety and Efficacy of an Anti-inflammatory Abtained from Active Ingredient of the Brazilian Biodiversity	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2013-01-01	Faculdade de Medicina de Ribeirão Preto - FMRP	Apis Flora Ind. Com. Ltda	https://ensaiosclinicos.gov.br/rg/RBR-9zmfs9	<NULL>	Healthy volunteers of both genders, non-smokers, aged 18 to 60 years and weighing within 15% of the normal weight for men and women taking into account their height and physical structure will be included. Participation of female volunteers is conditioned to not be pregnant or breastfeeding.	Volunteers with a history of smoking, alcoholism or drugs abuse, diagnosed as having any cardiac, renal, gastrointestinal, hepatic and pulmonary disease, neurological, psychiatric, hematological or metabolic disorders will be excluded. Also individuals with any known hypersensitivity to drugs who are receiving medications one week before the study or during its implementation and not willing to participate in all stages of this study will not be accept.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-596tn3	Effectiveness of manual lymphatic drainage on lymphedema of the lower limbs compared with the massage technique with smooth movements in reducing lymphedema lower limb.	Recruiting	Intervention	2013-08-31	<NULL>	<NULL>	237	Evaluation of lymphatic drainage and massage  to reduce lymphedema.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-05-01	Vascular Laser Center Ltda-Clinica Godoy	Vascular Laser Center Ltda-Clinica Godoy	https://ensaiosclinicos.gov.br/rg/RBR-596tn3	<NULL>	Patients with lymphedema of lower limbs, clinical diagnostic or lymphoscintigraphy,  without active infection or skin lesion. Both sexs ranging in age from 21 years and maximum 75 years.	Absence of lymphedema, presence of active infection or clinical contraindication for lymphatic drainage such as renal or cardiac decompensation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-2jcys5	Blood pressure increase during strength exercise conducted with different loads in people with high blood pressure treated with amlodipine.	Recruiting	Intervention	2013-08-31	<NULL>	<NULL>	238	Intra-arterial blood pressure responses during resistance exercise of different intensities in hypertensive patients treated with calcium channel antagonist.	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2010-09-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-2jcys5	<NULL>	"Essential hypertension
Men and Women
30 to 60 years
Sedentary
No target organ damage or secondary causes of hypertension according to the diagnostic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, University of Sao Paulo."	"Individuals with obesity (body mass index greater than or equal to 35 kg/m2),
Individuals with diabetes (fasting glycemia greater than or equal to 126 mg / dl),
Individuals with heart disease (previous diagnosis or alteration at rest or exercise ECG),
Average blood pressure greater than or equal 160/105mmHg.
Subjects who do not tolerate the study medication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-3vg4fd	Translation and Adaptation for Assessment of Trunk Control	Recruiting	Observational	2013-09-01	<NULL>	<NULL>	240	Translation and Adaptation Assessment of Trunk Control (SATCo)	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-09-09	UNIFESP	UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-3vg4fd	<NULL>	Individuals of both sexes and showing any kind of muscular dystrophy, aged 7 to 30 years	Patients without at least control head, which have recently undergone surgery of the spine, and exhibiting severe deformities in the spine. Patients whose parents and  or guardian, or the individual himself does not sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-96jrm5	Comparison between conventional physical therapy and Pilates&apos; Method in the evolution of functionality, respiratory muscle strength and exercise capacity in hospitalized chronic renal patients	Recruiting	Intervention	2013-09-01	<NULL>	<NULL>	241	Effectiveness of conventional physical therapy and Pilates&apos; method in functionality, respiratory muscle strength and ability to exercise in hospitalized chronic renal patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-01-09	UNIVERSIDADE CIDADE DE SÃO PAULO	Hospital do Rim e Hipertensão	https://ensaiosclinicos.gov.br/rg/RBR-96jrm5	<NULL>	No acute neuropathy or lung disease, or also rheumatic and orthopedic diseases associated that prevent them from performing the proposed protocol; those who have cognitive ability to respond to the questionnaire and ability to ambulate.	Will be excluded immediate postoperative abdominal surgery, from the upper or lower abdomen; those who present, at the time of hospitalization, the need for use of noninvasive mechanical ventilation and intubation; those who present thrombocytopenic; those with diagnosis of deep vein thrombosis and who require intensive medical support	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-4j9jpr	Use of insoles on the improvement in individuals after stroke.	Recruiting	Intervention	2013-09-16	<NULL>	<NULL>	245	Postural Insoles Influence  on  Functional Capacity of Individuals Post-Stroke: Study Randomized Controlled Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-10	Universidade Nove de Julho - Uninove - SP	Universidade Nove de Julho - Uninove - SP	https://ensaiosclinicos.gov.br/rg/RBR-4j9jpr	<NULL>	Participants will be selected based on the eligibility criteria: have a diagnosis of both hemorrhagic stroke as ischemic, with spastic hemiplegia, spasticity classification by modified Ashworth scale levels 1, 1 + and 2 have walk independently without the use of any device auxiliary or ankle-foot orthosis (AFO), have degrees of understanding and collaboration consistent with the achievement of the proposed activities, agree to participate in the study by signing the consent form.	Individuals with stroke who have undergone surgical procedures or the application of phenol in the last 12 months or neurolytic blocks in the last 6 months, and ankle deformities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-8gcx9m	Non-randomized clinical trial to assess the effect of a medication against cytomegalovirus in patients who are not infected originally cytomegalovirus but who have received renal transplantation from donors that are infected by cytomegalovirus.	Recruiting	Intervention	2012-11-06	<NULL>	<NULL>	246	A phase 2a single arm study to evaluate the effect of TCN -202 (human anti-cytomegalovirus monoclonal antibody) on CMV infection in CMV (cytomegalovirus) seronegative recipients of kidney allografts from CMV seropositive donors	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2013-08-27	Theraclone Sciences, Inc	Worldwide Clinical Research Monitoramento de Pesquisas Clínicas do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8gcx9m	<NULL>	Patients who are males or females aged 18 to 65 years, inclusive;Patients who are single-organ recipients (kidney only) and CMV seronegative and receiving a kidney transplant from a CMV seropositive (cadaver or living) donor;Females must not be pregnant or nursing and must either be of non-childbearing potential or must agree to use 2 acceptable methods of birth control and must agree to continue doing so for four months after the last dose of TCN-202;Females of childbearing potential and males with female partners with childbearing potential must agree to use effective contraception and must agree to continue doing so for four months after TCN-202 dosing;Adequate venous access and able to receive intravenous infusion;Patients must be able to understand the purpose and risks of the study and sign the informed consent form (ICF).	Patients who require anti-lymphocyte preparations for induction therapy (indication in the rejection of transplanted organs) or those who receive a kidney with a cold ischemia time higher than 30 hours;patients presenting any acute medical condition or significant past medical history or any condition that in the opinion of the Principal Investigator (PI) or the Sponsor would complicate or compromise the study, or the well-being of the patient;Patients with known positivity to Hepatitis B, Hepatitis C and HIV (1 and 2);Patients with history of cancer (except for non-melanoma skin cancer) within 2 years prior to transplantation;patients with history of drug or alcohol abuse within 6 months prior to transplantation;patients who have received an investigational product in any clinical trial within 12 months of transplantation;patients who have received prior treatment with a monoclonal antibody;Patients who require concomitant treatment with other investigational drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-237v4b	Effectiveness of an phythetapic in prevention and treatment of skin lesions caused by radiotherapy in patients with Head and Neck Cancer	Recruiting	Intervention	2013-09-16	<NULL>	<NULL>	247	Evaluating the efectiveness of calendula in the prevention and treatment of Head and Neck Radiodermatitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-10-03	Hospital Erasto Gaertner - HEG	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-237v4b	<NULL>	"Age above 18 years,diagnosis of cancer and head and neck radiotherapy, intact skin and continuous in the head and neck, first day of radiotherapy (if new), patients with no previous history of radiotherapy in the same field / local radiation,
Consent to participate in by signing the consent form (ICF)."	Previous reports of allergic reaction in the use of one of the research products (essential fatty acids or marigold).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-34khhv	Effect of Physical Exercise and Respiratory Therapy After Cardiac Surgery	Recruiting	Intervention	2013-09-19	<NULL>	<NULL>	251	Impact of Physical Exercise Associated to CPAP Application on Coronary Artery Bypass Grafting Surgery Postoperative	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-09-12	Universidade Federal de São Carlos	Irmandade da Santa Casa de Misericórdia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-34khhv	<NULL>	Volunteers with clinical diagnosis of coronary artery disease by coronary angiography and absence of acute or chronic lung disease, undergoing elective coronary artery bypass grafting surgery with cardiopulmonary bypass, median sternotomy incision type and interposition of saphenous vein graft, or internal mammary artery or radial.	Not perform the surgical procedure according to the technique already specified, reoperations and / or associated procedures like approach valvular or carotid endarterectomy, present malignant ventricular arrhythmias, complexes ventricular premature beats, supraventricular tachycardia or sinus greater than 120 beats per minute, atrioventricular block of 2nd or 3rd degree, signs of low cardiac output or ventricular failure, hypotension, heart failure and recent myocardial infarction (less than 6 months), present chronic obstructive pulmonary disease, diabetes mellitus with documented diabetic neuropathy and/or presence of disease in the kidneys and liver, users of heart pacemaker, general impairment, weakness, fever, and associated neurological sequelae and difficulty understanding and/or adherence to study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-96h8bx	Walking training with body weight support system on mobile and fixed surfaces in children with cerebral palsy who have gait impaired.	Recruiting	Intervention	2013-09-19	<NULL>	<NULL>	252	Partial body weight support system in fixed and mobile surface for walking training in subjects with locomotor system impaired	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Cruzeiro do Sul	Universidade Cruzeiro do Sul	https://ensaiosclinicos.gov.br/rg/RBR-96h8bx	<NULL>	Children aged 4 to 10 years; Diagnosis of hemiplegic or diplegic cerebral palsy; No cognitive, visual and verbal impairment that can interfere with the performance of tasks;Be classified between levels II and IV of the Gross Motor Function Classification System (GMFCS) for Cerebral Palsy.	Have be submitted to surgical procedures in the last 12 months before the start of training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:47
RBR-5n4y2g	Cardiovascular Health Care Program – PROCARDIO-UFV	Recruiting	Intervention	2013-10-21	<NULL>	<NULL>	260	Use of Different Strategies in Nutritional Intervention in the Cardiovascular Health Care Program – PROCARDIO-UFV	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-02-01	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5n4y2g	<NULL>	Age higher 20 years old, diagnosed cardiovascular disease or occurence of risk factors: dyslipidemia, hypertension, diabetes or metabolic syndrome, to be a worker or dependents&apos;worker or students of Federal University of Viçosa	Do not want to participate of the study; To be not a worker or dependents&apos;worker or students of Federal University of Viçosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-3xktv5	Auriculotherapy effectiveness in reducing smoking	Recruiting	Intervention	2013-12-09	<NULL>	<NULL>	267	Auriculotherapy effectiveness in reducing smoking	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-07	Universidade Federal de Alfenas	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-3xktv5	<NULL>	"Possessing 18 years of age or older;
Being a smoker (daily make use of any quantity of cigarettes, including a);
Present level of carbon monoxide in exhaled air (COex) above 6 ppm (parts per million).
Having the desire to quit smoking;
Voluntarily participate in the study with available time to commit to sessions of auriculotherapy."	"Infection, inflammation or injury to the ear;
Make use of ear piercing (except earrings normal);
Make some treatment for tobacco, medicinal or not.
Pregnant."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-26qdtg	Effects of everolimus (Certican) on cardiac hypertrophy and carotid atherosclerosis after kidney transplantation	Recruiting	Intervention	2014-01-16	<NULL>	<NULL>	271	Effects of Everolimus (Certican) on cardiac hypertrophy and carotid atherosclerosis after kidney transplantation	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2012-05-09	Hospital das Clínicas da Faculdade de Medicina de Botucatu	Hospital das Clínicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-26qdtg	<NULL>	The patient who agree to participate in the study, who have a consent form signed and meet the following criteria: age of 30 years or greater and being a recipient of de novo kidney transplant from a deceased donor or non-HLA identical living donor. At randomization time the patients needs to meet this criteria: creatinine clearance estimated by Cockroft-Gault formula of 40ml/min or greater and proteinuria of 800mg/day or less.	Patients will be excluded of the study if: with painel reactive antibody of 50% or higher, recipients of a second transplant with the first transplant loss for any immunological cause within the first year of transplantation, multi-organ recipient, ABO incompatible donor; non-beating heart donor; donor age of 5 yars or less and donor age of 65 years or higher. At the randomization  time, patients will be excluded if: they were on a rejection treatment, if they have history of Baff IIB or higher rejection insult, previous rejection resistant to corticosteroids, presence of subclinical rejection or severe inflammation on protocolar biopsy, presence of total blood cont leucocyte of 2500uL or less, neutrofiles of 1500uL or less, platelets of 75000uL or less, hemoglobin of 6,0g/L or less, liver disease or active infection, positive pregnancy test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-8ttw64	Effects of dietary guidance in children attending outpatient preventive cardiology: randomized clinical trial	Recruiting	Intervention	2013-12-09	<NULL>	<NULL>	272	Effects of dietary guidance in children attending outpatient preventive cardiology: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Instituto de Cardiologia Fundação Universitária de Cardiologia- IC/FUC	Número do Parecer: 400.879 - Comitê de Ética em Pesquisa do Instituto de Cardiologia do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8ttw64	<NULL>	Children both genders aged 7-11 years whose parents or caregivers signed an informed consent form, reside in the state of Rio Grande do Sul and having overweight overweight or obese according to the criteria of the World Health Organization.	Children with neurological disorders that interfere with learning, cognitive deficits eg Disorder Attention Deficit Hyperactivity Disorder; contraindications for physical activity group and using drugs that interfere with the body weight or lipid profile, such as statins, ritonavir, furosemide hidrocloritiazida, propranolol, nadolol, prednisolone among others.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:48
RBR-2vsvs3	Evaluation of granular Brazil-nut in the treatment of hypertensive and dyslipidemic.	Recruiting	Intervention	2014-02-10	<NULL>	<NULL>	277	Effect of the supplementation with granular Brazil-nut in the microcirculation and biomarkers in hypertensive and dyslipidemics subjects.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-01	Hospital Universitário Clementino Fraga Filho	Instituto Nacional de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-2vsvs3	<NULL>	Hypertensive and dyslipidemic patients between 20 and 100 years old.	Individuals with known food allergy or aversion to the Brazil nut;Pregnant women and nursing mothers,Be making use of dietary supplements containing antioxidant vitamins or minerals,Show untreated thyroid diseases and destabilized,Display chronic renal failure or liver disease, Being in substance use steroids,Show rheumatic heart disease or systemic collagen, Age up to 20 years and older than 100 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-6tx8y8	Primer orientation in the treatment of migraine.	Recruiting	Intervention	2014-03-21	<NULL>	<NULL>	280	Effect of additional guidance booklet to conventional therapy in reducing the frequency and intensity of migraine: a randomized controlled clinical study	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2013-08-01	Faculdade de Medicina de Ribeirão preto da Universidade de São Paulo	Maria Claudia Gonçalves	https://ensaiosclinicos.gov.br/rg/RBR-6tx8y8	<NULL>	200 subjects of both sexes, literate, aged between 18 and 65 years, with a diagnosis of migraine with or without aura, conducted by neurologists according to the criteria of the International Classification of Headache Disorders (2004) of the International Headache Society (IHS). Volunteers should have reported at least 2 attacks per month for at least one year, whether or not prophylactic drug treatment, regardless of the drug prescribed by the doctor and the existence or not of analgesic abuse	patients diagnosed with significant psychological disorders such as depressive disorders, bipolar disorder and schizophrenia, cognitive impairment, illiteracy or difficulty to understand or communicate in Portuguese, systemic diseases and chronic pain such as fibromyalgia and rheumatic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-5ph2zw	Impact of exercise on the urinary control muscles in women with Multiple Sclerosis	Recruiting	Intervention	2014-04-08	<NULL>	<NULL>	284	Impact of a pelvic floor training program on the quality of life of women with Multiple Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-01	Universidade Federal de Mato Grosso do Sul	Gustavo Christofoletti	https://ensaiosclinicos.gov.br/rg/RBR-5ph2zw	<NULL>	Women diagnosed with Multiple Sclerosis;  age over 20 years; score on the Expanded Disability Status Scale (EDSS) lower or equal to 6.5; presence of symptoms of urinary dysfunction for at least six months.	Refusal to participate; exacerbation of symptoms  of Multiple Sclerosis during treatment; cognitive decline;  imposibility to attend the treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-4z5z3t	Effects of therapeutic ultrasound on the vascular response	Recruiting	Intervention	2014-04-28	<NULL>	<NULL>	286	Effects of therapeutic ultrasound of low intensity in endothelial function	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-4z5z3t	<NULL>	Literate volunteers. Aged between 18 and 40 years old. Body mass index (BMI: kg/m2) less than 30. Have no symptoms of musculoskeletal disorders. Not making use of medication (except contraceptives), smoking and alcohol. Have no previous diagnosis of rheumatic diseases, cardiovascular, metabolic, neurological, oncological, haematological and immunological. Absence of psychiatric or cognitive problems.	Volunteers who performed high-intensity physical activity 72 hours before evaluations; presence of inflammatory response measured by the ultrasensitive PCR &gt;3mg/dL, fibrinogen &lt;200 or &gt;400mg/dL, leukocytosis &gt;11,000 x103/mm3, body temperature less than 38ºC, consumer beverages containing caffeine or alcohol, arterial diameter between &lt;2.5mm and &gt;5mm and endothelial dysfunction assessed by FMD (&lt;8%).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-36r3t5	Effect of elastic bandages on pain, swelling and strength in elderly subjects with knee osteoarthritis	Recruiting	Intervention	2014-04-29	<NULL>	<NULL>	287	Effect of kinesio taping on pain, swelling and strength in elderly subjects with knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-36r3t5	<NULL>	Volunteers of both gender, age over 60 years, presence of pain in knee (4/10 in visual analogue scale); joint stiffness of the knee at least six months for activities in the standing position; presence of joint pain during passive motion; intermittent swelling; radiographic joint degeneration.	Presence of systemic rheumatic disease; previous surgery of the lower limbs; some other condition that would limit or disable the implementation of proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-4n2sxr	Quantity of injuries, heat stress and physiotherapy in triathlon athletes after competition of middle and long distance	Recruiting	Intervention	2014-04-29	<NULL>	<NULL>	288	Epidemiology of injuries, heat stress and physiotherapy in triathlon athletes after competition of middle and long distance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4n2sxr	<NULL>	Athletes aged between 18 and 55 years; of both gender; they must complete triathlon&apos;s competition of middle and long distance and they must go to the physiotherapy sector of the competition; with pain in the muscles of the quadriceps femoris.	Presence of excoriation in the thigh area; perform other intervention to change to the sensitivity as cryotherapy, analgesic or anesthetic on site assessment;  presence of neurological or musculoskeletal disease that interferes or contraindicate the procedures for intervention and/or measurement; metabolic and severe breathing disorders; cramps during the assessment procedures or intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-56brsc	Impact of specific physcail therapy treatment on the health of patients with Parkinson&apos;s disease	Recruiting	Intervention	2014-04-30	<NULL>	<NULL>	289	Effects of cognitive-motor rehabilitation on non-motor symptoms of patients with Parkinson&apos;s disease: a controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Universidade Federal  de Mato Grosso do Sul	Universidade Federal  de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-56brsc	<NULL>	Volunteers of both gender, aged between 60 and 90 years, diagnosed with idiopathic Parkins&apos;s disease, with clinical profile indicating moderate impairment based on the Hoehn–Yarh scale and on the motor subscale of the Unified Parkinson&apos;s Disease Rating Scale	Patients with cognitive decline, those with movement disorders not compatible with a diagnosis of idiopathic Parkinson&apos;s disease (such as secondary Parkinsonism), subjects with congenital or acquired amaurosis and those with severe cardiovascular and musculoskeletal comorbidities that preclude orthostatism and deambulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:49
RBR-9yvx59	The effect of elastic bandage in patients with osteoarthritis of the knee	Recruiting	Intervention	2014-05-09	<NULL>	<NULL>	292	The effectiveness of taping in patients with osteoarthritis of the knee - randomized clinical trial: pilot study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9yvx59	<NULL>	adult patients referred AACD - Lar Escola São Francisco diagnosed with moderate knee osteoarthritis and agree to participate in the study according to the term informed consent	patients with rheumatic diseases associated orthopedic surgery of the lower limbs prior injections of steroids in the past six months, obesity (BMI&gt; 35), allergy to components of physiotherapy those who underwent banding in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-9g4yp2	Bioelectrical impendance analysis parameters evaluation as severity markers in patients admitted in intensive care unit.	Recruiting	Observational	2013-12-10	<NULL>	<NULL>	293	Bioelectrical impendance analysis parameters evaluation as severity biomarkers in the critically ill patient	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-02-15	Instituto Fernandes Figueira - Fundação Oswaldo Cruz	Vice-presidência de pesquisa e laboratórios de referência - Programa de desenvolvimento tecnológico em saúde pública (PDTSP)	https://ensaiosclinicos.gov.br/rg/RBR-9g4yp2	<NULL>	All patients aged 1 month to 6 years-old admitted to the pediatric intensive care unit that do not presented on admission with the outcomes studied (multiple organs dysfunction &gt; or equal 4 or septic shock).	Children weighing less than 3kg on admission in the pediatric intensive care unit; impossibility to perform bioimpedance measurement in the first 24h of hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-85693t	Association between the fall of the bladder or uterus and postural balance in elderly women	Recruiting	Observational	2014-05-13	<NULL>	<NULL>	294	Association between genital prolapse and postural balance in elderly women	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Raquel Henriques Jácomo	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-85693t	<NULL>	Women aged over 60 years old  and less than or equal to 80 years old.	Respiratory disorders, surgeries of the spine, abdomen, and pelvic floor central nervous system, brain tumors, neurological disorders, vestibular and limbic, central and peripheral degenerative diseases, trauma, clinical symptoms such as dizziness, tinnitus, hearing loss, ear fullness, postural hypotension, medicines that change the balance, uncontrolled diabetes mellitus, pelvic floor rehabilitation in the last year, visual impairment or patients with corrective lenses that did not follow the last 2 years, bone densitometry showing osteoporosis in past 3 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-39dz5v	The effect of electrical stimulation for the treatment of overactive bladder in elderly women	Recruiting	Intervention	2014-05-22	<NULL>	<NULL>	296	Motor and sensitive response after posterior tibial nerve stimulation in elderly women with overactive bladder syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2012-08-15	Faculdade de Ceilândia - FCE	Centro de Saúde 04 de Ceilândia - DF	https://ensaiosclinicos.gov.br/rg/RBR-39dz5v	<NULL>	Females aged 60 years, complaining of overactive bladder.	Women are excluded elderly who use pacemakers and metal implants in the region of the right ankle, being contraindications of electrotherapy, patients submit UTI by urine culture or have pain when urinating and/or suprapubic pain (interstitial cystitis), presenting with hematuria sterile urine (suspicion of carcinoma in situ of the bladder), women who use drugs to treat overactive bladder in the past six months and women with a neurological disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-7nynr7	Effect of skin-to-skin compared to the sweet solution for pain relief in newborns who require repeated blood collection.	Recruiting	Intervention	2014-05-28	<NULL>	<NULL>	297	"Effect of skin-to-skin compared to sucrose for pain relief in infants undergoing repeated painful procedures:
randomized clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-06-06	Escola de Enfermagem de Ribeirão Preto-USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7nynr7	<NULL>	Inclusion criteria: infants with gestational age greater than or equal to 36 weeks, which present Apgar score&gt; 7 at 5 minutes and clinical stability with maintaining physiological parameters in the normal range, ie, heart rate between 120 to 160 beats per minute (bpm). Mothers whose children are randomly assigned as skin to skin contact should be in physical and emotional conditions to breastfeed.	Exclusion criteria: infants who had birth trauma (fractures, skin lesions, soft tissue injuries cortocontusos, adiponecrose, bleeding from the sternocleidomastoid, brachial palsy, facial paresis, trauma of the sternocleidomastoid, intracranial hemorrhage, visceral rupture, bilateral paralysis of vocal cords, brachial palsy, facial palsy, spinal trauma and spinal cord and diaphragm paralysis), congenital malformations, difficulty swallowing, use of opioids in preterm and/or the mother less than six hours, presence of severe intraventricular hemorrhage or subsequent periventricular and contraindications of breastfeeding .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-63kf95	Effects of a program of exercises with increasing weight for individuals with coronary artery disease	Recruiting	Intervention	2014-06-10	<NULL>	<NULL>	303	Effects of a resistance physical exercise program based on determination of anaerobic threshold in increasing resistance testing in patients with coronary artery disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-63kf95	<NULL>	Mens with aged between 50 and 82 y,with a clinical diagnosis of coronary artery disease, with at least 12 months after the acute event or 12 months after surgical or percutaneous revascularization, nonsmoking, non-alcoholic, non-users of drugs that cause addiction, presence of clinical stability, absence of acute exacerbations of the disease, anaemias in general, electrolyte disturbances and / or uncompensated metabolic, absence of permanent pacemaker or defibrillator implants or valve, absence of respiratory disorders, signs of ischemia or ST segment depression, complex arrhythmias, left ventricular dysfunction, and absence of neurological, neuromuscular, musculoskeletal and osteoarticular disabling, controlled blood pressure and level of understanding that does not prevent the implementation the proposed protocol.	Smokers, women, people with impaired muscle and bone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-8d3sp7	The effect of meditation in reducing anxiety of individuals at the stage of weight loss maintenance	Recruiting	Intervention	2014-07-07	<NULL>	<NULL>	307	Efficacy of Healing Meditation in reducing anxiety of individuals at the stage of weight loss maintenance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-02	Escola Bahiana de Medicina e Saúde Pública - EBMSP	Escola Bahiana de Medicina e Saúde Pública - EBMSP	https://ensaiosclinicos.gov.br/rg/RBR-8d3sp7	<NULL>	Be over 18 years of age; take part in the slimming program of Centro Terapeutico Máximo Ravenna in the city of Salvador (Brazil); be at the stage of weight loss maintenance.	Individuals with diagnosis of psychosis; individuals who do not accept participation in the study; those who do not sign the Term of Free and Informed Consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-3rndh6	Electrotherapy in the treatment of pain during intercourse and assessment of the outcomes on the quality of life and sexuality of women with deep endometriosis	Recruiting	Intervention	2014-07-07	<NULL>	<NULL>	308	Transcutaneous Electrical Nerve Stimulation (TENS) in the treatment of deep dyspareunia  and assessment of the impact on the quality of life and sexuality of women with deep endometriosis: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-25	Ticiana Aparecida Alves de Mira	Ticiana Aparecida Alves de Mira	https://ensaiosclinicos.gov.br/rg/RBR-3rndh6	<NULL>	Sexually active women. Women in menacme. Diagnosis of endometriosis estages III, IV and/or of the rectovaginal septum. Deep dyspareunia.	Decreased skin sensitivity preventing the perception of the electric stimulus. Pregnant women. Pacemaker users. Hypersensitivity (allergic reactions to the gel or electrode). Epilepsy. Heart disease (arrhythmia). Osteosynthesis at the application site. Open sores. Malignant tumors. Acute inflammatory disease. Other associated gynecological pathologies. Cognitive disabilities that prevente the understanding of the use of the tools and/or conventional electrotherapeutic treatment or do not understand instructions for the use of the self-applied TENS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-386qsg	Influence of positive airway pressure in the range of reduced pressure after exercise in hypertensive Patients with Obstructive Sleep Apnea	Recruiting	Intervention	2014-07-09	<NULL>	<NULL>	313	Influence of positive airway pressure in the magnitude post-exercise hipotension in hypertensive patients with obstructive sleep apnea	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-05	José Heriston de Morais LIma	José Heriston de Morais LIma	https://ensaiosclinicos.gov.br/rg/RBR-386qsg	<NULL>	Sleep Apnea diagnosis, both genders, is between stage 1 and stage 3 hypertension; Being classified as Insufficiently active by Physical Activity Questionnaire; present classification in moderate to severe polysomnography; owning between 20 and 80 years, no history of previous lung disease, not present muscle damage, joint or bone that may compromise the partial or complete execution of any proposed exercise	Be classified as active in international physical activity questionnaire; presence of chronic lung disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:50
RBR-87rdwv	Association between facial types, orofacial pain and mastication	Recruiting	Observational	2014-09-01	<NULL>	<NULL>	331	Association between craniofacial morphology, temporomandibular disorders, bite force, masticatory performance and chewing ability	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-87rdwv	<NULL>	Experimental group: volunteers with TMD, established through the application of the RDC / TMD; both genders; aged between 18 and 45 years; complete permanent dentition (optional presence of third molars) and no more than a missing premolar in the quadrant. For the control group the inclusion criteria are the same, except the presence of TMD.	Subjects presenting history of oral and maxillofacial surgery, facial trauma to the jaw, orthodontic treatment in less than two years, bone disease or neuromuscular facial malformations, severe malocclusion (anterior open bite, unilateral or bilateral posterior crossbite), parafunction habits, facial deformities, or pregnant patients were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-79s56s	Evaluation of three Treatments of vivax Malaria	Recruiting	Intervention	2014-09-10	<NULL>	<NULL>	332	Safety and Efficacy Evaluation of Artemisinin-based Combination Therapy for the Treatment of Uncomplicated Plasmodium vivax Malaria	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2012-08-09	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-79s56s	<NULL>	Age between 18 and 70, or weight between 50 kg and 80 kg; Mono-infection by P. Vivax confirmed by microscopy; Asexual parasite count &gt; 250/µl; Axillary temperature &gt; 37,5 °C or history of fever during the 48h prior to recruitment; Ability to swallow the medicaments under study; Availability and desire to observe the schedule of evaluations of the study; Agreement with and signing of the Term of Free and Informed Consent.	Presence of clinical conditions related to malaria vivax that require hospitalization (coma, respiratory dysfunction or severe anemia); Presence of febrile conditions  due to another disease besides malaria (for example, measles, acute infection of the respiratory tract, diarrhea with dehydration) or other chronic or severe comorbidities (for example, kidney, cardiac or chronic liver disease, and HIV/AIDS); Use of medicaments that can interfere in the pharmacokinetics of the antimalarial medicaments under study; Hypersensibility to the medicaments under study; History of the presence of deficiency of glucose-6-phosphate dehydrogenase; Any significant disease or clinical findings during the medical evaluation or physical examination that the investigator considers might interfere in the study; Pregnancy (confirmed by ? HCG) or breastfeeding; Use of antimalarial treatment less than 63 days prior to the symptoms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-88b5jr	Diagnostic study of Dengue in Emergency Care	Recruiting	Intervention	2014-09-11	<NULL>	<NULL>	333	Pragmatic Diagnostic Trial  of Cinical-Laboratory Algorithm for Dengue in Emergency Care Units in Rio de Janeiro	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-05	Conselho Nacional de Desenvolvimento Científico e Tecnológico (	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-88b5jr	<NULL>	Patients of both genders over 18 years assisted in Emergency Care Units in Rio de Janeiro, with fever for up to 3 days without other infectious etiology.	pediatric patients and those with other infectious etiology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-3gm6w5	Glucose 25% and sucking gloved finger for pain relief of premature newborns during capillary glucose by heel prick	Recruiting	Intervention	2014-10-02	<NULL>	<NULL>	338	Glucose 25% and nonnutritive sucking for pain relief in premature undergoing heel lance: a clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-30	Escola de Enfermagem Anna Nery da Universidade Federal do Rio de Janeiro	Maternidade Escola da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3gm6w5	<NULL>	Prematures with gestational age at birth between 29 and 36 weeks complete; age after birth more than 06 hours; apgar score at five minutes of 7 or more; clinical stability with physiologic parameters at heart rate between 120 to 160 and oxygen saturation more than 89%; antecipated clinical need for at least 3 routine heel stick to control blood glucose after six hours post birth	"Ventilatory assistance; intraventricular hemorrhage(grades III
and IV)or leukomalacia; cromossomal disorders or malformations affecting central nervous system; disorders affecting cardiovascular system, presence of necrotizing intestinal colitis or hyperglycemia; use of opioids, corticosteroids, or other drugs that interfere with the responses to pain, children of mothers who use illegal drugs, trauma from childbirth as skin lesions, fractures, intracranial hemorrhage, visceral ruptures"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:51
RBR-4rprbd	Impact assessment of molecular tests for drug resistant tuberculosis diagnosis in Brazil	Recruiting	Intervention	2014-04-02	<NULL>	<NULL>	341	Policy Relevant Outcomes from Validating Evidence on Impact of Line Probe Assay and MTB/RIF on Presumptive Diagnosis of DR-TB in Brazil	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2011-10-14	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	Centro de Referência Professor Hélio Fraga	https://ensaiosclinicos.gov.br/rg/RBR-4rprbd	<NULL>	Age over 18 years; individuals or their legal representatives who sign the Consent Free and Clear; TB resistant suspected cases defined by the presence of history of previous treatment for TB; patients hospitalized in referral centers for TB at least once in the past 2 years; staying in nursing homes / hostels; homeless population; drug / alcohol abusers; HIV seropositive individuals and contacts of tuberculosis resistant patients positive smear	Pregnant; refusal to participate in any phase of the study; patients with resistant tuberculosis confirmed by culture and with appropriate treatment in progress; patients with tuberculosis results from another laboratory that will used by the physician to initiate anti tuberculosis treatment; extra-pulmonary TB suspected patients  (without sputum sample) and permanent patients in police and prisons	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-8k3cyk	Training Program for residents in breaking bad news in perinatology using standardized patients	Recruiting	Intervention	2014-11-05	<NULL>	<NULL>	347	Evaluation of a training program efficacy for residents in breaking bad news in perinatology using standardized patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-15	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-8k3cyk	<NULL>	First to fourth year residents in the gynecology and obstetrics program at FCM Unicamp; first and second year residents from pediatrics; third and fourth year residents from the Neonatal program.	Third and fourth year pediatric residents from areas other than Neonatology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-45yn9v	Evaluation of mandibular movements and chewing in women with face pain	Recruiting	Intervention	2014-11-18	<NULL>	<NULL>	351	Influence of education and self-care modalities on pain and function related to Chronic Temporomandibular Disorder: clinical trial, randomized, double-blinded, controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-20	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-45yn9v	<NULL>	Females, aged between 18 and 70 years, presenting chronic pain related to chronic temporomandibular disorder; not being in treatment for this painful condition; not be starting any treatment for any other painful condition such as fibromyalgia; back pain; neck pain or rheumatic changes; natural teeth or fixed prosthesis with posterior contention; be capable to reading and writing	Using removable partial denture; using complete denture or implantssuported fixed; debilitating systemic diseases as Parkinson or Alzheimer; use of a cardiac pacemaker; absence of severe malocclusions as crossbite; anterior open bite; midline deviation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-5wkdk7	Effects of the pressure of the hands on the chest to remove secretions from the lung in patients on life support	Recruiting	Intervention	2014-11-26	<NULL>	<NULL>	354	Effects of chest compression in patients on mechanical ventilation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5wkdk7	<NULL>	Patients of both genres; aged between 18 and 80 years; in use of an endotracheal tube or tracheostomy; receiving ventilatory support; sedated; hemodynamically stable; no active participation in the fan; having diagnosed the presence of lung infection	History of pulmonary disease; hemodynamic instability; abnormalities of the chest or abdominal wall; obesity; severe scoliosis; pregnancy; cardiac pacemaker; pneumothorax; flail ches;, presence of vascular fragility; acute respiratory distress syndrome; thrombocytopenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-8v5s6s	"Study of the use of LASER and Led light and exercises in Herniated Lumbar Disc


Study of the Efficacy of Laser, Led and Exercises Herniated Lumbar Disc"	Recruiting	Intervention	2014-12-02	<NULL>	<NULL>	356	Effects of low power LASER and LED associated with exercises and positioning in Lumbar Disc Herniation: a randomized clinical  trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-07-16	Universidade Estadual do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8v5s6s	<NULL>	Patients with HDL of L4,L5 and L5,S1 spaces with radiculopathy; patients referred by a neurosurgeon, neurologist, orthopedist and rheumatologist; compatibility between the MRI image and clinical symptoms.	Presence of low back pain without radicular manifestation; patients undergoing any surgery in the lumbar spine; pregnancy; fracture or tumor in the lumbar spine; history of collagen disorder; history of neoplasic disease;  patients with disc herniation in the spaces L2,L3 and L3,L4; individuals with pacemaker or with skin diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-9q7dy5	Oral treprostinil open label study  in subjects with pulmonary arterial hypertension	Recruiting	Intervention	2014-12-03	<NULL>	<NULL>	357	"An open-label extension study of UT-15C in subjects with pulmonary arterial hypertension - a long-term follow-up to
protocol TDE-PH-310"	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2013-09-01	Irmandade da Santa Casa de Misericórdia de Porto Alegre - ISCMPA	Pharmaceutical Research Associates Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9q7dy5	<NULL>	Patients who participated in the study TDE-PH-310 and met the definition of clinical worsening (as specified in the protocol TDE-PH-310), continued treatment with study drug, was compliant with assessments and study procedures during TDE-PH-310 or were enrolled in that study when it was discontinued by the sponsor. Women of childbearing potential must be on real abstinent or use two highly effective contraceptive methods throughout the study and for at least 30 days after discontinuation of study medication. Men participating in the study should use condoms throughout the study and for at least 48 hours after the last dose of study medication.	Pregnant or breastfeeding female patient. Patient receiving therapy with prostacyclin by infusion or inhalation. Patient who was early withdrawn from the study TDE-PH-310 due to reasons other than the event of clinical worsening. Patient developed a concomitant disease or condition during participation in the original study TDE-PH-310, which in the opinion of the study physician, would represent a risk to the general health if the patient were enrolled in this extension study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:52
RBR-3d29s2	Benefits of aerobic exercise on the cardiovascular system in patients with coronary artery disease.	Recruiting	Intervention	2014-12-09	<NULL>	<NULL>	361	Influence of interval aerobic exercise training on cardiorespiratory and metabolic variables and inflammatory markers in patients with different level of coronary artery lesions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-14	Departamento de Fisioterapia da Universidade Federal de São Carlos	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3d29s2	<NULL>	Volunteers men, aged 35 and 65 years with coronary artery disease udergoing percutaneous coronary intervention (&gt; 3 months), and/or cardiovascular risk factor (obesity, smoking, drinking, sedentary lifestyle, hypertension, non-insulin-dependent diabetes and dyslipidemia).	Patients with frequent extrasystoles, chronic obstructive pulmonary disease, unstable angina, osteomuscular disorders, diabetes mellitus – users of insulin, renal failure, and sequelae of stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-9c8wng	Acute and chronic cardiovascular responses to resistance training in individuals with intermittent claudication	Recruiting	Intervention	2014-12-09	<NULL>	<NULL>	363	Acute and chronic cardiovascular responses to resistance training in individuals with intermittent claudication	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2010-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9c8wng	<NULL>	Aged 45 to 85 years; both genders; be on stage II of Peropheral Artery Disease in one or both limbs, according with Fontaine criteria; be able to walk on a treadmill at least two minutes at a speed of 3.2 km/h; and, be with systolic and diastolic blood pressure levels less than 160 and 105 mmHg, respectively	Individuals who are in use of beta-blockers, calcium channel blockers or vasodilators non-dihidropiridinico; presenting complex arrhythmias or ischemia that contraindicate physical activity; having diabetes with complications or autonomic dysfunction, who are obese and they have amputated limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-6qkjzv	Evaluation of chewing elderly patients with Rheumatoid Arthritis	Recruiting	Observational	2014-12-15	<NULL>	<NULL>	364	Evaluation of masticatory capacity, pattern of mandibular movement, maximum bite force and quality of life in elderly patients with Rheumatoid Arthritis.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-06-10	Faculdade de Odontologia de Piracicaba - UNICAMP	Fundação de amparo à pesquisa do Estado de São Paulo (FAPESP)	https://ensaiosclinicos.gov.br/rg/RBR-6qkjzv	<NULL>	Volunteer possessing equal to or above 60 years of age; both genders; partially or total edentulous	Individuals who present severe malocclusions; submit systemic disease that could also  affect the muscle activity;dementia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-37f338	Comparative trial to evaluate the efficacy and safety of antibody treatment in patients with early breast cancer	Recruiting	Intervention	2015-01-12	<NULL>	<NULL>	370	A randomized, double-blind, phase 3 study evaluating the efficacy and safety of ABP 980 compared with trastuzumab in subjects with HER2 positive early breast cancer	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2013-05-01	Associação Hospital de Caridade Ijuí	Amgen Inc.	https://ensaiosclinicos.gov.br/rg/RBR-37f338	<NULL>	"Females equal or older than 18 years of age. Histologically confirmed invasive breast cancer. Planning for surgical resection of breast tumor and sentinel node (SN) or axillary lymph node resection. Planning neoadjuvant chemotherapy. HER2 positive disease defined as: 3+ overexpression by immunohistochemistry (IHC) or HER2 amplification by fluorescence in situ hybridization (FISH). 
Measurable disease (assessment method used in order of priority: ultrasound, mammography, MRI, or physical examination) in the breast after diagnostic biopsy, defined as longest diameter equal to or longer than 2.0 cm. Known ER and PR hormone receptor status at study entry. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Left ventricular ejection fraction (LVEF) of equal to or more than 55% by 2D echocardiogram. Normal bone marrow function as defined by: absolute neutrophil count (ANC) higher than 1.5 x 10^9 g/dL (1,500/microL); platelets higher than 100 x 10^9 g/dL (100,000/microL); hemoglobin higher than 10.0 g/dL. Normal hepatic function as defined by: total bilirubin within normal institutional limits; aspartate aminotransferase (AST) and alanine aminotransferase (ALT); lower than 2.5 × the upper limit of normal (ULN); subjects with an elevated unconjugated bilirubin (Gilbert&apos;s syndrome) will be eligible if hepatic enzymes and function are otherwise within normal limits (ie, AST, ALT, and Alkaline Phosphatase are within normal limits), and there is no evidence of hemolysis. Normal renal function as defined by creatinine lower than 1.5 × ULN or estimated creatinine clearance (CrCl) equal to or higher than 50 mL/min calculated by the Cockcroft- Gault method. 
Subjects must sign an IRB/EC-approved informed consent form before any study specific procedures."	Bilateral breast cancer. Presence of known metastases. Received prior treatment, including chemotherapy, biologic therapy, radiation or surgery with the exception of diagnostic biopsy for primary breast cancer. Other concomitant active malignancy or history of malignancy in the past 5 years except treated basal cell carcinoma of the skin or carcinoma in situ of the cervix. Pre-existing clinically significant (equal to or higher than grade 2) peripheral neuropathy. Any history of documented or current congestive heart failure, current high-risk uncontrolled arrhythmias, current angina pectoris requiring a medicinal product, current clinically significant valvular disease, current evidence of transmural infarction on electrocardiogram (ECG), or current poorly controlled hypertension. Severe dyspnea at rest requiring supplementary oxygen therapy. History of positivity for hepatitis B surface antigen, hepatitis C virus, or HIV. Recent infection requiring a course of systemic anti-infectives that were completed equal to or less than 14 days before enrollment (with the exception of uncomplicated urinary tract infection). Woman of childbearing potential who is pregnant or is breast feeding. Woman of childbearing potential who is not consenting to use highly effective methods of birth control (eg, abstinence, sterilization, birth control pills, Depo-Provera injections, or contraceptive implants) during treatment and for an additional 4 months after the last administration of the protocol specified treatment. Currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study. Other investigational procedures while participating in this study are excluded. Subject has known sensitivity to any of the products to be administered during the study, including mammalian cell derived drug products, trastuzumab, murine proteins, or to any of the excipients. Subject previously has enrolled and/or has been randomized in this study. Subject likely to not be available to complete all protocol required study visits or procedures. History or evidence of any other clinically significant disorder, condition or disease (with the exception of those outlined above) that, in the opinion of the Investigator or Amgen physician, if consulted, would pose a risk to subject safety or interfere with the study evaluation, procedures or completion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5dbpbv	Influence of deep foot manipulation in balance	Recruiting	Intervention	2015-01-26	<NULL>	<NULL>	376	Influence of support area plantar in balance and electromyographic activity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Estadual Paulista &quot;Júlio Mesquita Filho&quot; Campus Marília. Faculdade de Filosofia e Ciências	Centro de Estudos da Educação da Saúde (CEES)	https://ensaiosclinicos.gov.br/rg/RBR-5dbpbv	<NULL>	"Gender: females 
Healthy older; between 65 and 75 years; living in the community.
Healthy Young; between 18 and 28 years; living in the community."	The voluntary doesn&apos;t manages to remain in the postures of the test; that has orthopedic injury over the last 6 months or neurological damage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-4t57rs	Effects of elastic tape on fuctional activities on healthy young subjects	Recruiting	Intervention	2015-01-30	<NULL>	<NULL>	379	Effects of Kinesiotaping on functional performance on healthy young subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4t57rs	<NULL>	Healthy male subjects; aged 18 to 30 years; Physically active; Height between 1.65 m to 1.85 m; absence of pain and symptoms musculoskeletal	Presence of open wounds or scars in the region of application of KT; hypersensitivity and erythema; lower limb injury in the last 6 months prior to the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:53
RBR-5bxqm5	Evaluation of the use of a nasal spray containing a small amount of seawater, after nasal surgery and its impact on improving the quality of life of patients	Recruiting	Intervention	2015-02-10	<NULL>	<NULL>	385	Evaluation of the use of a nasal spray solution of sodium chloride 0.9% in the immediate postoperative septoplasty and turbinecotomy and its impact on quality of life of the patient	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2014-05-30	Hospital IPO - Hospital Paranaense de Otorrinolaringologia	Farmoquimica S.A	https://ensaiosclinicos.gov.br/rg/RBR-5bxqm5	<NULL>	Both sexes; between 18-65 years; indication for surgery septoplasty and inferior bilateral turbinectomy with dislocation of the turbinate; agreement to abide by the procedures and requirements of the test and attend to the Office (s) day (s) and time (s) given (s) for the evaluations	"Use of other nasal decongestant; use of analgesics and corticosteroids not described in the protocol; hypersensitivity (allergy) to components of the formula; use of topical medication in the nasal region; pregnant and lactating women; drinking alcohol during treatment; another surgery associated; 
Use of Gelfoan; packing and splints; 
Patients who have had surgery under general anesthesia;  other medical conditions considered by the investigator as reasonable for the disqualification of the individual participate in the study; postoperative complications (septal hematoma, heavy bleeding or tamponade requiring return to the operating room or infection)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-29kgz5	Exercices for pelvic muscles before and after pelvic organs prolapse surgery	Recruiting	Intervention	2015-02-10	<NULL>	<NULL>	387	Training of Pelvic Floor Muscles before and after Pelvic Organs Prolapse (POP) surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-29kgz5	<NULL>	Age between 35 and 80 years old; clinical complaints consistent with genital prolapse; medical indication for vaginal surgery to repair the anterior, apical and posterior defects, POP stages II, III and IV evaluated by the Pelvic Organ Prolapse Quantification (POP-Q); absence of prior correction of pelvic organ prolapse pelvic surgery; absence of present vaginal and urinary infections; women literate; absence of uncompensated endocrine disorders that may interfere with sexual function (hypothyroidism)	"Use of hormone  therapy;immediate complications related to the surgical correction of POP not resolved within 40 days after surgery (pain and infection vaginal vault); late complications not directly related to the surgery (post-anesthesia headache); women who do not accept any of the reviews make proposals;
women who do not meet the previous schedule of ratings of physical therapy and evaluations"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-6v4y3k	Transcranial current stimulation for childrens with cerebral palsy	Recruiting	Intervention	2015-02-11	<NULL>	<NULL>	389	Transcranial direct current stimulation associated with upper limb functional training for childrens with spastic hemiparetic cerebral palsy:a randomized controlled double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-07-10	Associação Educacional Nove de Julho	Associação Educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-6v4y3k	<NULL>	The criteria for inclusion will be children with  spastic hemiparetic cerebral palsy  come from school of physiotherapy clinics of UNINOVE which have, diagnosis of spastic hemiparetic cerebral palsy;functional classification of upper limbs as levels I, II or III for MACS; have age between 6 and 16 years old;have degrees of understanding and cooperation that are compatible with the achievement of the proposed activities;the legal guardians for the children, agree with your participation in the study through the signing of the informed consent already approved by the COEP UNINOVE	Will be excluded childrens who:have  performed surgery or neurolíticos locks procedures in the upper limb paretic, in the last 12 months before the beginning of the training sessions;have structured deformities with Orthopedic Surgical indications;have epilepsy;have metal implant in the brain or hearing aids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-3q8j43	A study to evaluate both the efficacy and safety profile of CP 690,550 in patients with moderately to severely active ulcerative colitis	Recruiting	Intervention	2015-02-17	<NULL>	<NULL>	391	A multicentre, randomized, double-blind, placebo controlled, parallel group study of oral CP 690,550 as an induction therapy in subjects with moderate to severe ulcerative colitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2011-10-21	Hospital de Clínicas de Porto Alegre (Centro Coordenador)	Laboratórios Pfizer Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3q8j43	<NULL>	"Subject must be at least 18 years of age; males and females with a documented diagnosis of ulcerative colitis (UC) at least 4 months prior to entry into the study; subjects with moderately to severely active UC based on Mayo score criteria; subjects must have failed or be intolerant of at least one of the following treatments for UC: corticosteroids (oral ou intravenous), azathioprine or 6 mercaptopurine (6MP), anti TNF alpha therapy (infliximab ou
adalimumab)."	"Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, or clinical findings
suggestive of Crohn&apos;s disease; subjects with disease limited to distal 15 cm; subjects without previous treatment for UC (ie, treatment naive); subjects displaying clinical signs of fulminant colitis or toxic megacolon."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-7jkbyg	Vestibular Rehabilitation assessment in elderly with vertigo	Recruiting	Intervention	2015-02-18	<NULL>	<NULL>	392	Vestibular Rehabilitation assessment in elderly patients with Benign Paroxysmal Positional Vertigo (BPPV)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-01-05	UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE	UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE	https://ensaiosclinicos.gov.br/rg/RBR-7jkbyg	<NULL>	Patients from both gender, had to be 65 years or older with clinical diagnosis of chronic subjective or objective BPPV in the posterior canal (minimum 6 months). They should agree to participate in the study according with the consent term informed. The patients will be referred from the Otoneurology ambulatory of the Hospital Universitario Onofre Lopes, and other public or private services of medical specialties who treat patients with dizziness complaint in Natal/RN city.	Patients with BBPV involving anterior or horizontal canal ; Other vestibular disorders ; neurological dysfunction, severe somatosensory and orthopaedic problems (osteoarthritis of knee or lower extremity deformity) will be excluded to eliminate confounding factors affecting balance performance; Uncontrolled metabolic diseases; Unable to understand and answer a simple verbal command; Previously underwent both ORM or Vestibular Balance Therapy; individuals who took vertigo medication during the study, and patients with neck disturbances that prevent them from performing the maneuver will be also excluded; Performing some physical activities such as: muscle strengthening exercises, pilates, yoga or high intensity aerobic exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-69yzkb	Effect of periodontal treatment on blood vessels and inflammation in type 2 diabetics with gum disease	Recruiting	Intervention	2015-02-19	<NULL>	<NULL>	396	Effect of periodontal treatment on endothelial and microvascular functions and gingival fluid and blood levels of immunoinflammatory biomarkers in type 2 diabetics with severe periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-11	Hospital Universitário Pedro Ernesto	Faculdade de Odontologia da UERJ	https://ensaiosclinicos.gov.br/rg/RBR-69yzkb	<NULL>	Patients with severe periodontitis; both genders; more than 18 years old; at least 12 teeth; type 2 diabetes mellitus	HIV; immunological and chronic inflammatory diseases; prolonged usage of medications 6 months before the start of the study as antibiotics; cortisone; antihistamine; hormones; and others	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-5pj5bb	Effects of mate tea consumption on muscle strength recovery and indicators of inflammation and damage caused by free radicals after exercise	Recruiting	Intervention	2015-02-23	<NULL>	<NULL>	399	Effects of mate tea (ilex paraguariensis) consumption on muscle strength and concentration of inflammatory and oxidative stress markers after eccentric exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-02-12	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5pj5bb	<NULL>	Healthy male, 19 to 30 years old; physically active.	Athletes; participation in formalized resistance or aerobic training programs in the previous three months preceding the study; smoking; having any disease, infection, or inflammatory processes; history of upper limb injury; and using any medication, ergogenic aids, herbal supplements, or vitamin/mineral supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-2h9smt	nterventions to enhance infection by the tuberculosis agent identification and treatment prescription in persosn without active disease.	Recruiting	Intervention	2015-02-24	<NULL>	<NULL>	402	Public health actions to enhance latent TB infection treatment.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-02	Rio de Janeiro Secretaria Municipal de Saúde	Centro de Pesquisas Aggeu Magalhães (CPqAM)	https://ensaiosclinicos.gov.br/rg/RBR-2h9smt	<NULL>	"In the first phase (diagnosis of the bottlenecks)
Subjects with active pulmonary tuberculosis and  their household contacts aged 18 or over; health care workers who assist tuberculosis patients

In the second phase (intervention):
Household contacts of patients with active pulmonary tuberculosis; any age; health care workers who assist tuberculosis patients"	Only in the first phase: not agreement to participate or sign the informed consent. No associated co-morbidity prevents the participant to take part in the study (mainly concerning active tuberculosis screening).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-78rn72	Evaluation cost of light apparatus for early detection of oral cancer in Goiás	Recruiting	Observational	2015-02-25	<NULL>	<NULL>	403	Technology assessment in the implementation of a screening and matrix model of oral cancer in Goias state: study of cost-effectiveness of visual inspection and inspections with florescence	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-08-15	Faculdade de Odontologia da Universidade Federal de Goiás	Universidade de Malmö	https://ensaiosclinicos.gov.br/rg/RBR-78rn72	<NULL>	Individuals of both genders; smokers who use cigarretes since 1 month ago at least; consuming alcoholic drinks at least once per week; with sun exposure over 2 hours per day; history of sexually transmitted disease; over 40 years old	Individuals who do not accept signing the informed consent, or if they fail any of the conditions described in the inclusion criteria, or do not allow the assessment of the oral cavity under white light or under the violet light	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:54
RBR-8bvqz2	Effect of nursing interventions using the telephone	Recruiting	Intervention	2015-02-26	<NULL>	<NULL>	408	Effectiveness of nursing interventions using the telephone	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-24	Escola de Enfermagem da Universidade de São Paulo-EEUSP	Escola de Enfermagem da Universidade de São Paulo-EEUSP	https://ensaiosclinicos.gov.br/rg/RBR-8bvqz2	<NULL>	Being a family caregiver of a person with chronic illness; aged over 18 years; reading and writing,to have a longer than a month taking care of the family; to  have telephone service, to have a nursing diagnosis Caregiver Role Strain	Caregiver with cognitive impairment, assessed by the Mini Mental State Examination (MMSE) test;to have limitations for speech and hearing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-96kvrq	Efficacy and safety of corticosteroids use in severe pulmonary inflammation in children	Recruiting	Intervention	2015-03-02	<NULL>	<NULL>	409	Phase II, randomized, placebo-controlled, double-blind clinical trial to evaluate the effects and safety of infusion of low-doses of Methilprednisolone in early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) in children	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2015-02-01	Instituto D&apos;Or de Pesquisa	Instituto de Puericultura e Pediatria Martagão Gesteira - Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-96kvrq	<NULL>	Pediatric patients in mechanical ventilation; diagnosis of ALI/ARDS within the first 72 hours based on the current literature criteria; informed consent properly signed; both genders; age range from 29 days to 18 years.	ALI/ARDS with more than 72 hours of diagnosis; failure to obtain written informed consent  to participate in the study; condition requiring &gt; 0.5mg/Kg/day of prednisone equivalent; primary or secondary neuromuscular dysfunction; patients using aminoglycosides combined with neuromuscular blockers; cardiopulmonary arrest within 7 days or anytime during present hospitalization prior to enrollment; irreversible cessation of all brain function; immunosuppression acquired or congenital, including HIV+ status; history of bone marrow or solid organ transplantation; current malignancy, neutropenia, receiving cytotoxic therapy for any reason, and acute burn injury; severe chronic liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-6gphkr	"CQAB149BAR01 - 24-week study to assess which treatment is safer and bring more benefits to patients with COPD (Chronic Obstructive Pulmonary Disease)
combination budesonide / indacaterol vs fluticasone /
salmeterol"	Recruiting	Intervention	2015-03-04	<NULL>	<NULL>	412	"CQAB149BAR01 - 24-week study to evaluate efficacy and safety of the
combination budesonide / indacaterol vs fluticasone /
salmeterol in patients with COPD"	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-02-28	Novartis Biociências S.A.	Novartis Biociências S.A.	https://ensaiosclinicos.gov.br/rg/RBR-6gphkr	<NULL>	Patients both genders, age greater than 40 years in outpatient treatment with a diagnosis of COPD in groups C and D, according to the GOLD with post-bronchodilator FEV1 &lt;60% guidelines and 30% predicted, FEV 1 / FVC post-bronchodilator &lt;0.7; smoking for at least 10 pack-years (defined as 20 cigarettes per day for 10 years or 10 cigarettes per day for 20 years and so on); smokers and ex-smokers are eligible; history of at least one exacerbation of COPD.	Patients requiring oxygen therapy for chronic hypoxemia (excluding acute exacerbation of COPD), typically with oxygen&gt; 15 h per day; COPD exacerbation within 6 weeks prior to visit 1 or between visits 1 and 2 or the presence of infection of the upper or lower respiratory tract infection during the screening period (Visit to 2) shall be permitted to a new screening after a minimum and 6 weeks after resolution of the episode; Pulmonary disease associated, for example, (except confirmed by chest radiography and no longer active) pulmonary tuberculosis or clinically significant bronchiectasis, sarcoidosis, interstitial lung disease or pulmonary hypertension; known diagnosis of deficiency of Alpha-1 Antitrypsin; Pulmonary lobectomy; lung volume reduction or lung transplantation; participation in the active phase of a program of supervised pulmonary rehabilitation; Asthma history marked by (but not limited to):.. onset of respiratory symptoms (coughing, wheezing, shortness of breath) suggestive of asthma before age 40 and history of a diagnosis of asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-7n2d2f	Cranial electrical current associated with gait training on a treadmill in people who have had a stroke.	Recruiting	Intervention	2015-03-04	<NULL>	<NULL>	413	Transcranial direct-current stimulation combined with treamill training for Stroke:a randomized, controlled, duble-blind, clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Conselho Nascionla de Pesquisa (CNPq)	Conselho Nascionla de Pesquisa (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-7n2d2f	<NULL>	Patients with a diagnosis of stroke. Both sexes. Age between 50 and 70 years. Able to walk independently.	Patients with stroke who have joint pain in the lower limbs that compromise the function. What have contractions in the joints of the lower limbs. With cardiovascular and cognitive changes that make it impossible to perform the tests. With metal implants in the head.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-3rqmgh	Effect of stimulation with electrical current in fibromyalgia:randomized clinical trial	Recruiting	Intervention	2015-03-17	<NULL>	<NULL>	421	Effect of TENS in fibromyalgia:randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-17	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3rqmgh	<NULL>	Will be included patients with fibromyalgia, diagnosed according to the criteria of the American College of Rheumatology, female, aged 18 to 60 years, without physical therapy concomitant.	Subjects will be excluded if they have concomitant rheumatologic disease, severe psychiatric disorders or any contraindication to prevent the use of the IC, such as allergies to the electrodes, cardiac pacemaker, pregnancy, epilepsy, skin conditions or deficient skin sensation in the areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:55
RBR-97bztb	Program for health promotion in schools of public elementary school in the state of Rio Grande do Sul	Recruiting	Intervention	2015-03-19	<NULL>	<NULL>	426	Intervention program for health promotion in schools of public elementary school in the state of Rio Grande do Sul: clinical randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-02	Instituto de Cardiologia de Porto Alegre/Fundação Universitária de Cardiologia	Instituto de Cardiologia de Porto Alegre/Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-97bztb	<NULL>	Healthy volunteers enrolled in participating schools; both genders; aged 2 to 18 years;	Health problems that do not allow anthropometric evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-7mcr59	The effect of music on the anxiety of children before surgery: a nursing intervention	Recruiting	Intervention	2015-03-31	<NULL>	<NULL>	431	The music listening applied to children undergoing surgery: a nursing intervention to relieve anxiety	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-22	Distrito Federal Secretaria de Saude	Distrito Federal Secretaria de Saude	https://ensaiosclinicos.gov.br/rg/RBR-7mcr59	<NULL>	children; age 3 to 12; both genders; to be subjected to any elective surgery; who agree to participate in the study, from the signing of free and informed consent term; that has a charge which agrees the child to participate in the research, from the signing of informed consent and informed	Children under 3 years of age and over 12 years; that will undergo emergency surgery; who have received premedication before the intervention to be tested; who have hearing problems and mental disorders; children or guardians who do not consent to take part or that are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-82qrd2	Effect of overload and relief of air excess in the lungs on exercise capacity in people with Pulmonary Chronic Obstructive Lung Disease	Recruiting	Intervention	2015-03-31	<NULL>	<NULL>	432	Effects of pulmonary hyperinflation on the kinetics of oxygen uptake  in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-03	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-82qrd2	<NULL>	We will test 21 patients to reach a final eligible 7 patients with Chronic Obstructive Pulmonary Disease stage severe or very-severe and aged 40 to 75 years ; free of exacerbation for at least 2 months; on regular use of prescription drugs; should be able to perform spirometry and exercise testing; both gender; without important comorbidities like other chronic obstructive lung disease or cardiopathy; free of chronic domiciliar oxygen therapy	Patient with  ischemic heart disease ; recent myocardial infarction;  pulmonary arterial hypertension;  uncontrolled systemic hypertension;  diabetes mellitus or  anemia ; furthermore can not participate in the study patients with severe aortic stenosis or  musculoskeletal or rheumatic diseases and  inability to use cycle ergometer for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-8ndqzk	The importance of information on quality of life of women with Polycystic Ovary Syndrome	Recruiting	Intervention	2015-04-07	<NULL>	<NULL>	437	Evaluation of the impact of access to information on quality of life of women with Polycystic Ovary Syndrome, a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-12-03	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8ndqzk	<NULL>	Being in the premenopausal period; between 15 and 50 years old; having the diagnosis of Polycistic Ovaries Syndrome by the Rotterdam criteria (2003); give written, informed consent to participate.	Previous psychiatric disorder; associated comorbidities that may affect the quality of life, such as diabetes, heart failure, collagen diseases, difficult to control hypertension, chronic kidney disease and obesity grade II or more;level below the 4th year of elementary school.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-4hvfzj	Physiotherapy techniques in Parkinson&apos;s Disease	Recruiting	Intervention	2015-04-07	<NULL>	<NULL>	439	Physiotherapy approaches in Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-02	Sociedade Unificada de Ensino Augusto Motta - UNISUAM	Instituto de Neurologia Deolindo Couto (INDC) - Universidade Federal do Rio de Janeiro (UFRJ)	https://ensaiosclinicos.gov.br/rg/RBR-4hvfzj	<NULL>	Signed the Free and Informed Consent Statement; age of 50 to 80 years; both sexes; diagnosis of idiopathic Parkinson&apos;s disease (PD) according to the UK Parkinson&apos;s Disease Brain Bank; stage 1-3 on the Hoehn and Yahr disability scale; ability to ambulate alone for 10 meters; be using regular medication for PD; target sample of 60 participants.	Cognitive impairment (Mini-Mental less than or equal to 18); other neurological disorders; hypertension or uncontrolled arrhythmia; severe visual impairment uncorrected; vertigo; presence of metal implant brand or pacemaker; constant headache and without diagnosis; history of convulsion; use of medication that alters cortical excitability; younger than 50 years; older than 80 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:56
RBR-6y4ghx	Biological and psychological correlates of mental illnesses	Recruiting	Intervention	2015-04-14	<NULL>	<NULL>	446	Biological and neurocognitive markers in neuropsychiatry	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-23	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6y4ghx	<NULL>	Fifty patients with a diagnosis of obsessive-compulsive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); aged between 18 and 50 years; with at least primary school; able to use computers; under regular pharmacological treatment for at least 3 months.	Any condition that hinders the smooth progress of the procedure as psychiatric comorbidities that impedes the assessment with the dotprobe task or with symptom severity scales; cardiac pacemakers and some brands of cerebral aneurysm clips; cochlear implants and neurostimulators; firearm projectiles and other metal fragments depending on the location in the body.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-9t48g5	Analysis of fatigue and immune response in patients with and without cancer treated with video game	Recruiting	Intervention	2015-04-16	<NULL>	<NULL>	450	Analysis of fatigue and immune response cells in cancer patients treated with exergames Randomized and controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-01	Faculdade de Fisioterapia da Universidade Federal de Alfenas	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9t48g5	<NULL>	"Control group: Healthy individuals; both sexes; aged between 18 and 80 years.
Experimental group: individuals with cancer;  both sexes; aged between 18 and 80 years; chemotherapy; radiotherapy; after surgery with medical clearance for physical activity."	Cognitive disorders that hinder the explanation of the handling of virtual environments; serious infectious diseases; disabling diseases in upper and lower limbs; patients with myopathies; diseases with recognized change of collagen; with neurological diseases; for personal reasons do not wish to participate; previous contact with exergames.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5stwwm	Effects of Tranexamic Acid on surgical tretament for severe nasal bleeding	Recruiting	Intervention	2015-04-17	<NULL>	<NULL>	452	Effects of intravenous Tranexamic Acid on surgical arterial ligations for severe epistaxis	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2013-10-01	Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Universidade Federal de São Paulo (UNIFESP)	Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-5stwwm	<NULL>	Patients with severe spontaneous epistaxis; indication of surgical treatment; both genders; 18-90 years-old.	Formal contraindications to the use of tranexamic acid; acute vaso-occlusive disease; active intravascular coagulation; hypersensitivity to the components of the formula; known coagulopathy; use of oral anticoagulants; altered coagulation tests; use of the drug on the 7 days before inclusion in the study; patient&apos;s refusal to participate in the study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-3st9f3	Osteopathic effects in patientes with heart disease	Recruiting	Intervention	2015-04-17	<NULL>	<NULL>	454	Effects of osteopathic manipulative treatment ( OMT )in  functionality of patients with congestive heart failure: a randomized clinical trial .	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-06	FCE - Faculdade de Ceilândia	FCE - Faculdade de Ceilândia	https://ensaiosclinicos.gov.br/rg/RBR-3st9f3	<NULL>	"For the experimental group : Congestive heart failure , cardiovascular disease, Chagas disease
For the control group : not having cardiovascular disease and be over 18 years."	"For the experimental group : New York Heart Association class I, hemodynamically decompensated patient , signs or symptoms of cardiovascular worsening in the last 3 months.
For the control group : cardiovascular disease , hypertension, surgeries , fibromioalgia , dysautonomia."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-6gs2jh	Evaluation of the Use of Antiseptic Nose For Decolonization of Resistant Bacteria in Hospitals	Recruiting	Intervention	2015-04-24	<NULL>	<NULL>	455	Evaluation of the efficacy of nasal application of silver sulfadiazine for decolonization of patients with methicillin-resistant Staphylococcus aureus in hospitals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-25	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gs2jh	<NULL>	Patients admitted in the Hospital das Clinicas, Ribeirão Preto Medical School, University of Sao Paulo; age over 18 years; isolation of methicillin-resistant Staphylococcus aureus.	Volunteers carry cystic fibrosis; patients with chronic osteomyelitis; carry infection related to foreign body; topic pregnancy with a live fetus; negative nasal swab for methicillin-resistant Staphylococcus aureus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:57
RBR-5h6rzs	Effect of inspiratory muscle training on respiratory muscle	Recruiting	Intervention	2015-05-11	<NULL>	<NULL>	467	Effect of inspiratory muscle training on adaptation structural and neural of respiratory muscle	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade Federal do Rio Grande do Norte	Rafaela Pedrosa	https://ensaiosclinicos.gov.br/rg/RBR-5h6rzs	<NULL>	Male and female; aged between 18 and 29 years; absence of visible deformities in the spine; absence of respiratory or neurological disease; absence of other significant pathology that could interfere in the recording of the electrical signal; BMI between 19 and 25 kg/m2; not show lesions at sites of electrode placement; FEV1/FVC&gt; 80% and FEV1&gt; 80% predicted; not being a smoker; not practice regular physical activity.	Inability to perform the protocol established by the study; present any problems during data collection; be unable to understand and/or perform procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-6wmjys	Body awareness therapy in women after breast cancer surgery	Recruiting	Intervention	2015-05-13	<NULL>	<NULL>	470	Effects of body awareness therapy in cardiac autonomic modulation of women after surgery for breast cancer	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-20	Universidade Estadual Paulista Julio de Mesquita Filho- FCT/UNESP	Universidade Estadual Paulista Julio de Mesquita Filho- FCT/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6wmjys	<NULL>	Women undergoing removal surgery for breast cancer; regardless of the type of procedure; mastectomy or quadrantectomy; with up to 1 year after surgery. For the control group healthy women; who didn&apos;t have cancer.Both groups aged between 40 and 60 years.	For women who have had breast cancer include non-medical consent, diagnosed metastasis; be in period of treatment with chemotherapy or radiation.For women in the control group the exclusion will be present another diagnosed pathology or any other type of cancer.Exclusion for both groups include arrhythmias; cardiac pacemaker or transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-2q2vt5	Effects of inspiratory muscle training in patients with asthma	Recruiting	Intervention	2015-05-14	<NULL>	<NULL>	472	Effects of inspiratory muscle training in patients with asthma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Departamento de Fisioterapia	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2q2vt5	<NULL>	Asthmatic adults: confirmed diagnosis of asthma, based on the criteria of the Global Initiative for Asthma, 2012; controlled asthma; aged between 18 and 60 years; absence of prior lung disease cystic fibrosis kind, bronchiectasis, tuberculosis and pneumonia. Healthy adults: Age between 18 and 60 years; absence of prior asthma-like lung disease, cystic fibrosis, bronchiectasis, tuberculosis and pneumonia; pulmonary function and respiratory muscle strength of normal.	Appearance of some lung during the training period; inability to perform the protocol established; solicitaçãoo to exit the study;  accession training protocol smaller than 80%; overweight.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4d6wyn	Elastic bandages for pregnancy back pain	Recruiting	Intervention	2015-04-06	<NULL>	<NULL>	474	Kinesio taping for pregnancy lumbar pain: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-18	Faculdade Anhanguera de Campinas - unidade 3	Faculdade Anhanguera de Campinas - unidade 3	https://ensaiosclinicos.gov.br/rg/RBR-4d6wyn	<NULL>	Pregnant women with low back pain; between 20 and 30 gestational weeks; singleton pregnancy.	Pathology of the spine; urinary tract infection; pathology that limits daily activities; cognitive impairment; dermatitis or infection in the banding application site; known allergy to the material of the bandage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4v7j2d	Effect of maternal vitamin A supplementation on vitamins A and E in breast milk.	Recruiting	Intervention	2015-05-18	<NULL>	<NULL>	475	Assessment of maternal vitamin A supplementation on the retinol levels and alpha-tocopherol in human milk.	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-12-01	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	https://ensaiosclinicos.gov.br/rg/RBR-4v7j2d	<NULL>	Healthy volunteers; term delivery; conception without defect; aged 18-45 years; without a history of miscarriage; without the use of vitamin supplements during pregnancy containing vitamin A or E.	Premature birth; diagnosis of gastrointestinal, infectious, liver, heart, syphilis, HIV positive or neoplasms; conceptus multiple; with use of vitamin supplements during pregnancy containing vitamin A or E.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4gj3hm	Infant development of children whose mothers with HIV	Recruiting	Observational	2015-05-18	<NULL>	<NULL>	480	Evaluation of infant development of children born soropositive mothers	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Universidade Federal de São Paulo	KAITIANA MARTINS DA SILVA	https://ensaiosclinicos.gov.br/rg/RBR-4gj3hm	<NULL>	Children at ages 4,8,12 and 18 months of age whose mothers have HIV-positive diagnosis, inserted in a program of monitoring of children born to HIV positive mothers in a reference service (SENIC), absence of associated diseases and signing the Informed Consent Form (ICF) by parents or guardians. For the control group (CG), are born at term, matched in age, gender and socioeconomic status to (EG).	Children born to seropositive mothers presenting malformation, genetic syndromes, congenital abnormalities, postural deformities or other changes that may bring harm to the socio-cognitive and psychomotor development of children, or that parents do not sign the consent form, or even by any reason not to complete the assessment protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-5nw65z	Heart rate recovery after the exercise: influence of neural mechanisms	Recruiting	Intervention	2015-05-21	<NULL>	<NULL>	483	Heart rate recovery after exercise: regulatory mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Laboratório de Hipertensão do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-5nw65z	<NULL>	Men. Aged between 40 and 60 years. Non smokers. Physically inactives (did not perform physical activity more than twice a week). Normotensives and hypertensives will form different groups. Hypertensives should not have end organ damage or secondary causes of hypertension according to the diagnotic rotine of the Hypertension League of Clinical Hospital, Faculty of Medicine, USP.	Subjects with obesity level 2 or greater(body mass index equal or greater than 35 kg/m2). Subjects with diabetes (fasting glycemia equal or greater than 126 mg/dl). Subjects with cardiac diseases (previous diagnosis or alteration on resting or exercise ECG). Use of anti-hypertensive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:58
RBR-4j35g5	Evaluation and treatment of changes due of pregnancy and postpartum	Recruiting	Intervention	2015-06-01	<NULL>	<NULL>	491	Evaluation and treatment of changes in gait, postural balance, strength of pelvic floor, sexual function, sleep and quality of life in cycle puerperal pregnancy:randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-08-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4j35g5	<NULL>	Does not provide obstetric and clinical  changes;  age between 18 and 37 years;  are in the second ( 16th to 20th weeks) or third (28th to 32th weeks) trimesters of pregnancy; confirmed by ultrasonography; were nulliparous;  single-fetus pregnancy;  no physical activity during the survey period; no history of depression or anxiety;  do not use drugs / substances that affect balance or sleep;  report changes in the quantity or quality of sleep;  no history of balance disorders and sleep before pregnancy;  has identified changes in postural balance through the Balance Master®;  absence of previous surgery in spine, pelvis, hip and knee;  no history of epilepsy and photosensitivity;  absence of musculoskeletal, cardiopulmonary and neurological disorders that prevent the completion of the evaluation and treatment protocols; no modifications of the pelvic floor muscles before pregnancy ;  no changes in sexual function before pregnancy; having a steady partner for at least six months	"to present clinical and obstetric change; be  under 18 and more than 37 years; be in the 1st trimester; be multiparous; twin pregnancy; physical activity during the study period; present history of depression or anxiety; make use of drugs / substances that affect balance or sleep; not report changes in the quantity or quality of sleep; report history of balance and sleep disorders before pregnancy; without alterations postural balance identified through the Balance Master®; report previous surgery on spine, pelvis, hip and knee; report history of epilepsy and photosensitivity, musculoskeletal, cardiorespiratory and neurological disorders that impede the completion of the evaluation and treatment protocols; report changes of the pelvic floor muscles before pregnancy; show changes in sexual function before pregnancy; not have a steady partner for at least six months
Criteria for removal of study: Miss three consecutive meetings or not the Preparatory Course for Pregnancy, Childbirth and Postpartum or the intervention sessions; complaining against any nuisance arising from stimuli demonstrably offered during the exercises; refused to complete the questionnaires and present obstetric complications during the period of the research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6sckn6	Simplified technique for dentures: the influence of denture quality, chewing ability and patient satisfaction	Recruiting	Intervention	2015-06-01	<NULL>	<NULL>	495	Simplified technique for complete dentures: influence on             quality prostheses, masticatory function and patient satisfaction.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-13	Faculdade de Odontologia de Piracicaba Universidade de Campinas	Secretaria municipal de saúde de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-6sckn6	<NULL>	60 volunteers will be selected edentulous. Both genders. Aged between 40 and 90 years. The Volunteers should be in good general health.	Volunteers sign or symptom of dysfunction temporomandibular.Que lost teeth for less than a year. Who do not have cognitive ability. That are not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4psjwb	Self-care program  focusing on the assistive devices effects for individuals with hand osteoatrhritis	Recruiting	Intervention	2015-06-05	<NULL>	<NULL>	500	Self-care program focusing on the Assistive Technology effects for patients with the hand OA	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-11-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4psjwb	<NULL>	The sample consists of 40 volunteers with the following inclusion criteria: Hand OA diagnostics (ACR); Be registered at the Hospital das Clinicas, Federal University of Pernambuco; minimum age 18 and maximum age of 90 years.	Surgical treatment or infiltration in the hands in the last 6 months;Treatment of occupational therapy and / or physical therapy or use of any TA feature (assist device or split) in the last 6 months; Diagnosis of another rheumatologic disease or musculoskeletal disease that compromise the hands.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-47hhbj	Effects of Auriculotheray in women during labor	Recruiting	Intervention	2015-06-07	<NULL>	<NULL>	504	Effects of Auriculotheray in women during labor: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Enfermagem da Universidade Estadual de Campinas	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM/UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-47hhbj	<NULL>	99 women in labor; 37 weeks gestation or more; single and cephalic fetus; cervical dilation greater than or equal to 4 cm; two or more contractions in 10 minutes; skin integrates the ear.	Pregnant women with severe hypertensive disease; pregnancy bleeding; previous cesarean section; dilated cervix equal to or greater at 7 cm; analgesic drug use for less than 6 hours of admission in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-6hjt5q	Effectiveness of using teleconsultation in discharge in referral hospital for patients with stable coronary disease	Recruiting	Intervention	2015-06-08	<NULL>	<NULL>	506	Evaluation of the effectiveness of the use of teleconsultation in qualifying the counter-referral between primary and tertiary care to patients with stable coronary artery disease: a randomized non-inferiority trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-08	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6hjt5q	<NULL>	Chronic stable coronary artery disease over a year; functional class I or II at the time of consultation; do not have hospitalization in the last year from cardiovascular disease	Unstable patients who require medication adjustments; Patients who are performing some diagnostic evaluation at query time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-9ygmdn	Effect of different kinds of physical training (aerobic, resistance and concurrent) on vascular function and blood pressure in hypertensive individuals	Recruiting	Intervention	2015-06-08	<NULL>	<NULL>	507	Physical Training Effect on Endothelial Function and Blood Pressure in Hypertensive Patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-04	Instituto de Cardiologia - Fundação Universitária de Cardiologia/ ICFUC	Coordenação de Aperfeiçoamento de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-9ygmdn	<NULL>	Patients aged between 18 and 75 years; diagnosed with hypertension; not participate in any kind of systematic physical activity; be ranked among insufficiently active, as IPAQ; signing the consent form; not present hyperreactivity during the test the physical tests (SBP&gt; 220 mmHg and / or increase of more than 15 mmHg for DBP); not febrile and / or infectious disease state, as well as diabetes mellitus; not class II obesity or more 35 kg / m2; not present heart failure class III or IV; recent cardiovascular event in the last three months; chronic renal failure; history of malignant disease with a life expectancy &lt;2 years; not be active smoker and not present alcoholism; not have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises.	Patients outside the age range of 18 to 75 years; without diagnosis of hypertension; be participating in some kind of systematic physical activity; not sign the Instrument of Consent; hyperreactivity present during the test the physical tests, presenting fever and / or infectious disease as well as diabetes mellitus; class II obesity or having more than 35 kg / m2; present heart failure class III or IV; cardiovascular event in the last 3 months; chronic renal failure; history of malignant disease with a life expectancy &lt;2 years; be active smoker and present alcoholism, have orthopedic impairments or any physical or mental limitation that prevents the performance of physical exercises; will still be excluded from the sample individuals who have not obtained attendance to 85% of the number of training or miss more than two consecutive workouts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:16:59
RBR-4rnq3v	Effects of a workout program in patients with HIV and cocktail use for over than one  year and treated at a university hospital: a randomized clinical trial	Recruiting	Intervention	2015-06-09	<NULL>	<NULL>	511	Effects of a program of periodized resistance exercise in patients with HIV in HAART therapy more than one year and served in a university hospital: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-06	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4rnq3v	<NULL>	"Be patient infected with HIV and use of antiretrovital therapy for over one year seen at the Infectious and Parasitic Diseases sector of a university hospital. Be older than 18 and less than 60. Having health conditions for the practice of the proposed exercise. Being sedentary. Having availability displacement three times per week for the training local.
Target sample: 34 patient."	Having diagnosis of opportunistic infections in the last two years. Having a diagnosis of liver disease and/or nephropathy and/or neuropathy. Have a history of orthopedic surgery. Have an body mass index&gt; 30 kg / m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8jg3bk	Electric current therapy for patients with pain caused by circulatory problems in the legs and feet	Recruiting	Intervention	2015-06-11	<NULL>	<NULL>	514	Transcutaneous electrical nerve stimulation in patients with pain caused by chronic lower limb ischemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-26	Universidade Federal  de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-8jg3bk	<NULL>	72 hospitalized patients; diagnosed with critical ischemia of the lower limbs; of both genders; aged over 18; with ischemic rest pain in the lower limbs; who are waiting for vascular surgery.	Patients with contraindication for application of electrotherapy; patients who have already undergone therapy with transelectrical nerve stimulation prior to the trial.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-5ns6sg	Effects of Exercise and Diet on the Functional Status, Nutritional Status, Lipid Profile and   Life&apos;s Quality in Hemodialysis patients	Recruiting	Intervention	2015-06-21	<NULL>	<NULL>	518	Effects of Exercise and Nutritional Intervention on the Functional Status, Nutritional Status, Lipid Profile and   Life&apos;s Quality  in hemodialysis patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5ns6sg	<NULL>	155 patients of both sexes; aged 20 and 79; for at least three months in haemodialysis treatment; sedentary; kidney therapy performed through access fistula; and adequacy of treatment of haemodialysis (Kt/V&gt;1.2.	patients with disability and severe orthopedic impairments; acute myocardial infarction history in the last six months; recent hospitalization (&lt;3 months; decompensated diabetes; consuming vitamin supplement; which have thyroid dysfunction; and patients who have food intolerance baru.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-72kkgc	Use of surfactant with corticosteroids to prevent chronic lung disease in premature infants	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	519	Intratracheal instillation of budesonide, using surfactant as a vehicle, in the prophylaxis and rescue therapy of neonatal respiratory distress syndrome to prevent bronchopulmonary dysplasia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-13	Hospital das Clínicas da Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-72kkgc	<NULL>	Every newborn with 0-2 hours of life; both sexes; who required prophylactic surfactant or early redemption replacement therapy. Sample size target: 90 research subjects.	"Loss of follow-up of the newborn before 28 days of chronological age (except in case of death);
Congenital malformations of heart and lung; except patent ductus arteriosus and pervious foramen ovale."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-2jgrkq	Use of Postoperative Intravenous Iron in Abdominoplasty After Bariatric Surgery	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	520	Use of Postoperative Intravenous Iron in Abdominoplasty After Bariatric Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-04-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2jgrkq	<NULL>	Sample size: 56 patients, Women; 18 to 55 years old; previous bariatric surgery; BMI less than 32 kg/m2; Stability of weight loss for at least 6 months	smoking; cholelithiasis demonstrated on ultrasound; uncontrolled systemic diseases; bone marrow diseases; hematological disorders; presence of renal or hepatic insufficiency; acute infection; prior use in the last three months of intravenous iron; hemoglobin level less than 11.5 g/dL; ferritin level less than 11 ng/mL or greater than 100 ng/mL; transferrin saturation index below 20% or exceeding 50%; a level of less than 210 pg/mL vitamin B12; folic acid level of less than 3,3 ng/ml, albumin level less than 3 g/dL; C-reactive protein greater than 5mg/L; mean corpuscular volume less than 80 fL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-6cf6rp	Effectiveness of lithium microdose in the treatment of Alzheimer&apos;s disease.	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	521	Prospective, double-blind, randomized, placebo-controlled, longitudinal study to evaluate the effectiveness of lithium microdose in the treatment of Alzheimer&apos;s disease.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-10	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6cf6rp	<NULL>	Will be included in the study: patients clinical diagnosed with Alzheimer&apos;s disease by the Neurology Department of Medical School of Santa Casa Sao Paulo Hospital, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM, fourth edition), National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and Alzheimer&apos;s Disease and Related Disorders Association; Patients who have a score 1 or 2 in the Clinical Dementia Rating (CDR), characterizing mild and moderate stages of AD, respectively; Patients who are using Alzheimer’s disease FDA-approved drug for at least six months, prescribed by the Neurology Department of Medical School of Santa Casa Sao Paulo Hospital; Patients who have 60 years old or older; Education: everybody could be included in this study, but the years of education must be considered to memory score tests; adjustments should be made in accordance with the scholarity;  Do not include prescription of drugs with central nervous system action in the first six months of treatment, unless strictly necessary conditions and it must be highlighted in the patient evolution; Agreement with and signing of the informed consent form; Having a caregiver (familiar member or formal caregiver) who is responsible for the patient&apos;s participation in the study.	Will be excluded in the study patients who don’t have a clinical diagnosis of Alzheimer&apos;s disease; patients who have a score 3 in clinical dementia rating, i.e. late stage dementia; patients who suffer from diseases that may have contraindications for the use of lithium carbonate, as: kidney failure; patients who have a lithium intolerance; patients who have used lithium for other conditions;  patients with lithium serum levels above the acceptable range, i.e. 1.2 mEq/ L in plasma; patients with renal failure; patients with hypothyroidism or goiter, if not controlled; violation of the protocol; loss of follow-up; discontinuing treatment; by request of patient or caregiver; death; patients who don’t agree to participate in the study. Notes: Frequent and prevalent comorbidities in the elderly are not considered exclusion criteria, such as hypertension, diabetes, vitamin B12 deficiency, among others. These patients will be enrolled in the study with appropriate notes and the possible differences observed in these patients will be compared with normal elderly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-8f6qsw	self-care effect in patients with shoulder pain	Recruiting	Intervention	2015-06-23	<NULL>	<NULL>	522	Self-care effect in the medication and function of patients with shoulder pain indicated to physiotherapeutic treatment: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8f6qsw	<NULL>	shoulder pain for more than three months; age above 18 years; patients on the waiting list for physical therapy treatment of shoulder painful conditions in the city of Ribeirão Preto.	systemic diseases; inflammatory diseases; uncontrolled hypertension, frozen shoulder; joint instability; malignancy; shoulder surgery in the last six months; people unable to perform self-care; people unable toanswer the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-2x8wqc	Evaluation of a therapy for the treatment of constipation in infants.	Recruiting	Intervention	2015-06-24	<NULL>	<NULL>	525	Randomized clinical trial double-blind efficacy of Prebiotics in Chronic Constipation Funcinal in infants	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2011-09-16	Universidade Federal de São Paulo	SKL Functional Nutrition	https://ensaiosclinicos.gov.br/rg/RBR-2x8wqc	<NULL>	"Infants attending for the first time in the Department of Ambulatory Pediatric Gastroenterology at UNIFESP - EPM;
Hypothesis diagnosis of chronic functional constipation;
Infants (children under two years old);
Infants of both genders; 6-24 months;
Infants artificial feeding
(over six months old)."	"Infants with clinical signs and symptoms suggestive of Hirschsprung&apos;s disease, including: delay in the elimination of meconium, growth retardation, abnormalities in skin pigmentation, presence of extra-intestinal symptoms and lack of response to conventional treatment (Aguirre et al, 2002 );
 infants who had an organic cause of constipation, secondary to other pathologies, such as deformities in the gastrointestinal tract, hypothyroidism, rickets, malnutrition, Chagas disease or neuromuscular diseases (Cury, 2005);
Infants who present False constipation;
Infants who have anemia or iron deficiency are iron therapy with ferrous sulfate;
Hypothesis diagnosis of chronic functional constipation discarded after the first week of observation in the study;
Regular use over the past thirty days, dietary fiber supplement;
Chronic use of medications that act on intestinal motility and cause constipation (prokinetics, antacids, anticonvulsants, diuretics, hematin, antispasmodics, anti-inflammatories), with the exception of ferrous sulfate;
Need other therapeutic interventions;
Infants who had poor nutritional status, malnutrition or obesity;
Children living in cities or neighborhoods whose distance to the clinic or family socioeconomic conditions that preclude their attendance at scheduled follow-up visits;
Infants who were exclusively breastfed or mixed;
Infants who make use of formulas containing prebiotics;
Parents or guardians illiterate, who can not help of another person literate in child care during follow-up project;
Not responsible for the child&apos;s consent to participate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-5zy6vw	Effect of varicocele correction surgery on the quality of sperm	Recruiting	Intervention	2015-06-24	<NULL>	<NULL>	526	"Varicocelectomy effect on the spermatic DNA fragmentation: clinical trial
with random assignment of participants"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-02-10	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5zy6vw	<NULL>	Men with varicocele in grades II and III; aged between 18 and 45; not having undergone previous varicocelectomy.	Smoking; excessive use of alcohol; drug abuse; genetic damage; prior varicocele correction surgery; testicular trauma; urogenital infections suspicion; cancer; endocrinopathies; treatments that may influence the testicular functions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-6y5dcb	Homeopathy versus Sertraline for depression	Recruiting	Intervention	2015-06-25	<NULL>	<NULL>	529	Homeopathy versus Sertraline	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-05	Unidade de Saúde Escola da Universidade Federal de São Carlos	Unidade de Saúde Escola da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6y5dcb	<NULL>	Subjects should meet the criteria for a depressive episode (single or recurrent) following a Structured Clinical Interview,SCID; capacity and willingness to give informed consent and to comply with study procedures will also be required.	Dysthymia; psychotic, chronic or double depression; intolerance to sertraline or a negative previous experience with the drug; bipolar disorder; schizophrenia or other psychotic disorders;  substance dependence (except tobacco); bulimia or anorexia, clinical significant chronic disease that could hinder study visits or depression evaluation;  suicide attempt up to 12 months before screening; treatment with antidepressants or mood stabilizers 4 weeks prior to the screening; homeopathic treatment 8 weeks prior to study entry; psychotherapy, meditation or acupuncture during the study; participation in a previous clinical trial 3 months prior to screening; concomitant pregnancy or breastfeeding; epilepsy;  concomitant use of anticoagulants; patients who are assumed to have a linguistic, intellectual or any other reason for not understanding the meaning of the clinical trial and for not complying with the necessary study procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:00
RBR-3h7f9k	Investigation of the effect of phytosterol consumption (plant extract) on the levels of cholesterol and blood fractions in children and adolescents with abnormal lipid levels in the blood treated at a university hospital.	Recruiting	Intervention	2015-06-26	<NULL>	<NULL>	532	Investigation of the therapeutic effect of phytosterol on LDL-cholesterol concentrations in dyslipidemic children and adolescents in a university hospital, randomized crossover study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-28	Hospital Universitário Pedro Ernesto/Universidade do Estado do Rio de Janeiro (UERJ)	Hospital Universitário Pedro Ernesto/Universidade do Estado do Rio de Janeiro (UERJ)	https://ensaiosclinicos.gov.br/rg/RBR-3h7f9k	<NULL>	dyslipidemic children and adolescents; both genders; aged 6 to 19 years, patients arising from the Outpatient Nutrition in Pediatrics and the Center for Studies of the University Hospital Adolescent Health Pedro Ernesto; plasma lipid values equal to or greater than 170 mg / dL for total cholesterol after they followed the diet less than seven percent saturated fat and total energy intake less than 200 mg cholesterol per day for a minimum period of four months.	volunteers with preexisting cardiovascular disease; metabolic diseases associated with dyslipidemia; any endocrine disorders. Children and adolescents who present triglyceride levels above 300 mg; use of food or any medications that may cause changes in the lipid profile; pregnant adolescents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-27kdyf	Light therapy and electrical stimulation on functional performance in volleyball athletes	Recruiting	Intervention	2015-07-06	<NULL>	<NULL>	537	Low level laser therapy and neuromuscular electrical stimulation on knee extension strength and jump in volleyball athletes: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-27kdyf	<NULL>	Healthy volunteers; volleyball players; gender male; non-smoking; aged between 17 and 18; weight within 15% variation limit of normal weight for male athletes, taking into account height and physique.	smoking volunteers; history of alcohol or substance abuse; diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic disorders; that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-9qjgsf	Pathogenicity of Candida species identified in denture  after the use of cleansers solutions	Recruiting	Intervention	2015-07-07	<NULL>	<NULL>	538	Expression of virulence genes and virulence factors of Candida species identified in dentures biofilm after using cleansers solutions.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-10-13	Faculdade de Odontologia de Ribeirão Preto FORP/USP	Faculdade de Odontologia de Ribeirão Preto FORP/USP	https://ensaiosclinicos.gov.br/rg/RBR-9qjgsf	<NULL>	Patients with stomatitis Prosthetics; use of conventional dentures; base and artificial teeth in acrylic resin; at least use time one year; appropriate conditions of prostheses; presence of biofilm on the inner surface of the prosthesis.	Prostheses with problems in adaptation; reline; repair or fractures; Use of antifungals; antibiotics or steroids in the past 3 months; anemia; immunosuppression or cancer therapy; other immunosuppressive diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:01
RBR-4tswsq	Strength training effects with elastic tubes on muscle strength, functional capacity, inflammation and quality of life of apparently healthy individuals	Recruiting	Intervention	2015-07-16	<NULL>	<NULL>	547	Strength training effects with elastic tubing in the functional, biological variables and quality of life of apparently healthy individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Universidade Estadual Julio de Mesquita Filho - UNESP	Universidade Estadual Julio de Mesquita Filho - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-4tswsq	<NULL>	Adults between 45 and 80 years;both genders; insufficiently active.	Clinical instability; cardiac disorders, musculoskeletal, neurological, pulmonary dysfunction, irregularity in the frequency of the sessions, refusal to sign the consent form, dependence tobacco.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-22t943	Impact and cost effectiveness of a protocol for diagnosis and treatment of tuberculosis in HIV/AIDS patients	Recruiting	Intervention	2015-07-16	<NULL>	<NULL>	548	Impact on mortality and cost-effectiveness of a protocol for diagnosis and treatment of tuberculosis in People Living with HIV	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-21	Conselho Nacional d eDeswenvolvimento Cientifico e Tecnologico	Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-22t943	<NULL>	HIV positive patients who were diagnosed with HIV; aged 18 years or over; and attended in Correia Picanco Hospital before initiating ART.	Being treated for TB; We have been treated for tuberculosis in the last three months; be receiving antiretroviral therapy over a month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:02
RBR-453vyf	Effects of early aerobic exercise after cardiac surgery	Recruiting	Intervention	2015-07-27	<NULL>	<NULL>	562	Effects of early aerobic exercise after coronary artery bypassa grafting: a randomized controlled clinical trial during hospitalization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Hospital Universitário da Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-453vyf	<NULL>	Patients undergoing elective coronary artery bypass surgery in the proposed period.	Use of intra-aortic balloon or other invasive device inserted by femoral artery;Surgical reintervention immediate postoperative period; Perioperative death; Prolonged Hospitalization above 10 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-57hj7n	Effects of supplementation with L-carnitine in the heart of patients who will do coronary artery bypass graft	Recruiting	Intervention	2015-07-30	<NULL>	<NULL>	569	Effects of supplementation with L-carnitine on ischemia and reperfusion and left ventricular function and remodeling in patients with heart failure after coronary artery bypass surgery	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-02	Universidade Federal Fluminense	Instituto Nacional de Cardiologia/INC	https://ensaiosclinicos.gov.br/rg/RBR-57hj7n	<NULL>	Sixty adult patients; lucid; oriented; both genders; minimum age of 30 years and maximum age of 80 years; diagnostic systolic ischemic heart failure; requiring elective coronary artery bypass surgery; use of cardiopulmonary bypass (CPB); Ejection fraction of the left ventricle (LVEF) greater than or equal to 50% (Simpson method); left ventricular end-diastolic volume (LV Diastolic) greater than 150 mL / m²; end of the left ventricle systolic volume (LV Systolic) greater than 65 ml / m².	During treatment develop liver dysfunction; renal dysfunction; malabsorptive syndrome; stroke; sepsis; prolonged hemodynamic shock; Patients who discontinue supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:03
RBR-9gh4km	Impact of a program of global exercises on balance and memory of subjects with Mutiple Sclerosis	Recruiting	Intervention	2015-07-31	<NULL>	<NULL>	572	Effects of cognitive-motor rehabilitation in patients with Multiple Sclerosis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9gh4km	<NULL>	Thrity volunteers of both gender; diagnosis of Multiple Sclerosis; age above 18 years.	Refusal to participate; exacerbation of symptoms of Multiple Sclerosis during treatment; cognitive decline; imposibility to attend the treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-2xzcwz	Homeopathy in the cocaine-crack dependence.	Recruiting	Intervention	2015-08-02	<NULL>	<NULL>	573	Homeopathic potencies of Opium and Erythroxylum coca  in the integrative treatment of cocaine dependence: randomized, parallel group, placebo controlled, double-blind trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-25	Unidade de Saúde Escola (USE) da Universidade Federal de São Carlos/UFSCAR	Centro de Atenção Psicossocial Álcool e Drogas de São Carlos-SP	https://ensaiosclinicos.gov.br/rg/RBR-2xzcwz	<NULL>	104 patients who meet the criteria for cocaine dependence from the International Statistical Classification of Diseases and related health problems 10th revision - World Health Organization.  Fixed address; capacity and willingness to give informed consent and to comply with study procedures were also required.	Cocaine abstinence at inclusion interview; disabling clinical or psychiatric diseases that would hinder regular participation in the study. Acupunture or homeopathic treatment simultaneously to the study; simultaneous participation in another clinical trial; pregnancy; patients who are assumed to have a linguistic, intellectual or any other reason for not understanding the meaning of the clinical trial and for not complying with the necessary study procedures. Patients that after inclusion and first medical visit do not return for any visit will be excluded and their data will not be used for statistical analysis only for &quot;lost to follow-up&quot; total. Motivation for change will be briefly assessed and subjects in precontemplation or contemplation states regarding cocaine and/or crack dependence will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-695twt	Treatment with electrotherapy on sleep quality in postmenopausal women with urinary urgency complaints and sleep interrupted by the urge to urinate	Recruiting	Intervention	2015-08-07	<NULL>	<NULL>	575	Effects of electrical stimulation of the posterior tibial nerve on sleep quality in postmenopausal women with symptoms of overactive bladder and nocturia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-02	Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-695twt	<NULL>	They will be included 40 postmenopausal women (over 12 months of amenorrhea); aged between 40 and 90 years; presenting urinary urgency and nocturia.	Women with postmenopausal time less than 12 months; presenting apnea; restless legs syndrome; mild to severe depression and mild to severe anxiety; heart disease uncontrolled; presence of prolapse of pelvic organs; presence of pelvic pain; history of pelvic surgery, except cesarean surgery; uterine bleeding; inflammation and / or urinary tract infection; diabetes mellitus; smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-4bvwxq	Transcutaneous Electric Nerve Stimulation Effect in Parkinson&apos;s Disease	Recruiting	Intervention	2015-08-11	<NULL>	<NULL>	576	"TENS Effect in Parkinson&apos;s Disease:
Randomized Clinical Essay"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4bvwxq	<NULL>	Inclusion criteria comprehend:subjects of both sexes and aged between 50 and 80 years; presence of motor fluctuations; conventional antiparkinsonian therapy excluding amantadine , clozapine, deep brain stimulation or pallidotomy and previous thalamotomy; ability to remain standing for at least 10 minutes; ability to walk independently with or without assistive devices; complaint of pain in the spine, with the presence or absence of irradiation to limbs and characterized as neuropathic (continuous and diffuse spontaneous pain, sensory loss, allodynia and hyperalgesia). Targer sample 80 patients.	Subjects will be excluded if: the medical or physical examination scores below 24 on the Mini Mental State Examination; there are systemic conditions, such as heart disease, that would interfere with the participation in the study; there is musculoskeletal damage or excessive pain in any joint that may limit participation in an exercise program; there is psychiatric disorder, cognitive decline or dementia influencing the communication process; there is musculoskeletal, cardiopulmonary or neuromuscular disorder ,recent or unresolved, which may affect their ability to walk or mobility; they are under physiotherapeutic treatment during the period of training; there is presence of contraindications for use of TENS, such as ulcerations or allergy to the material; there was previous use of TENS; there is chronic use of opioids or antidepressants; there is use of a cardiac pacemaker; there is reduced sensitivity at sites where the electrodes will be placed; there was previous back surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-2fbqp5	Swallowing and its implications on nutritional status and inflammatory markers	Recruiting	Observational	2015-08-13	<NULL>	<NULL>	580	Swallowing and its implications on nutritional status and inflammatory markers	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-04-09	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2fbqp5	<NULL>	Experimental group with 100 patients with age equal or higher than 19 years; both sexes; without a diagnosis of cancer; without treatment with antibiotics and anti-inflammatory 30 days before collection. Control group healthy volunteers; eutrophic; matched for age and sex with the study group.	Experimental group excluded smokers; patients with fever; diagnosis of edema; cancer; individuals on antibiotics; nonsteroidal anti-inflammatory drugs; immunosuppressants; antihistamines; corticosteroids; chemotherapy; radiotherapy within 30 days before collection of datos.Grupo control excluded patients with pulmonary diseases; cardiovascular; degenerative; neurological; arthritis; cancer; diabetes; smokers; pregnant women and women in the menstrual period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:04
RBR-5x69x2	Action of Acupuncture on the ear to reduce pain in muscles and bones	Recruiting	Intervention	2015-08-17	<NULL>	<NULL>	589	Contribution of Auricular Acupuncture for reduction chronic musculoskeletal pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-15	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5x69x2	<NULL>	Size of Target Sample: 200. Age (18 years or more); orientation in time; place and person; report the presence of chronic pain (existing for six months or more); score more than four on the Numerical Pain Intensity Scale; have availability of time for submission to auricular acupuncture sessions.	Have infection; inflammation or injury to the ear; make use of piercing (except ordinary earring); people who have allergies to metal or micropore; those who use other energy therapies (massage; herbal medicine; reiki; flower therapy); physical therapy in period of auricular acupuncture; make continued use of medication for pain relief; do not answer three tries against to the researcher; refuse to receive the headset processing with needles and pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-8jtkww	The effect of muscle strengthening in children with cerebral palsy	Recruiting	Intervention	2015-08-18	<NULL>	<NULL>	593	The effect of strengthening exercises on the functional aspects and patterns of muscle recruitment in children with cerebral palsy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-06	Universidade Federal de Uberlândia	Hospital e Centro de reabilitação da Associação de Assistência a Criança Deficiênte	https://ensaiosclinicos.gov.br/rg/RBR-8jtkww	<NULL>	Children with cerebral palsy, that are in treatment of rehabilitation at Association Assistance for Disable Child (AACD)in the city of Uberlândia-MG, who have between six to fifteen years old, whose parents or guardians have signed consent forms; that present motor level I, II, III do Gross Motor Function Classification System (GMFCS) and that present to perform cognitive tasks Gross Motor Function Measure (GMFM)and that did not undergo into medical procedures (botulinum toxin and surgery) for six months and have no deformities or pain	Children with clinical instability, such as seizures or who require frequent hospitalizations or those who have pain and deformity or those who have three absences in a month	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-55f97c	B12 Effect of supplementation and pulmonary rehabilitation in aerobic performance in patients with chronic obstructive pulmonary disease: a randomized study	Recruiting	Intervention	2015-07-14	<NULL>	<NULL>	597	Eight-week effect of physical training with vitamin B12 supplementation on functional capacity in patients with Chronic Obstructive Pulmonary Disease (COPD )	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-01	Universidade Federal de Mato Grosso do Sul - UFMS	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-55f97c	<NULL>	Volunteers with chronic obstructive pulmonary disease stages III and IV of the GOLD second disease; both sexes ; aged between 40 and 80 years ; at least four weeks free of disease exacerbation ; former smokers ; Current diagnosis or without other cardiopulmonary conditions such as asthma , interstitial lung disease , pulmonary hypertension , cardiac insufficiency or arthropathy , which does not allow exercise tests .	"Volunteers with Chronic Obstructive Pulmonary Disease stages I and II of the disease according to GOLD criteria; participating in any program
cardiopulmonary rehabilitation ; which show no ability to perform pulmonary function tests, gradual or exhaustive effort load
constant; Volunteers with heart disease, dilated bronchi , rheumatic diseases , physical deformities that prevent the achievement of exercise or
that are not available to participate."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-32vkkr	Inspiratory muscle training in intensive care unit patients.	Recruiting	Intervention	2015-08-27	<NULL>	<NULL>	599	Ventilatory weaning in intensive care unit (ICU): evaluation of maximum inspiratory pressures and inspiratory muscle training with powerbreathe®.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-16	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-32vkkr	<NULL>	Adequate gas exchange as indicated by a PaO2 above 60 mmHg while breathing with an FIO2 of 0.50 or less; hemodynamically stable for 24 hours prior to participation or requiring only minimal intravenous pressor agents (dobutamine or dopamine less than 5mcg/kg/min, phenylephrine less than 1 mcg/kg/min); be able to follow simple verbal directions related to inspiratory muscle strength testing and training; receiving assist control or SIMV (synchronized intermittent mandatory ventilation) or pressure support ventilation via a tracheostomy, pressure support ventilation less than 15 cmH2O and PEEP (positive end expiratory pressure) less than 10 cmH2O. Unable to sustain unsupported breathing for at least 24 consecutive hours following resolution of factor(s) precipitating respiratory failure.	Inadequate gas exchange as indicated by a PaO2 under 60 mmHg while breathing with 0.50 or less percentage of oxigen; be medically instable and unready to be weaned from the ventilator as determined by the attending physician; hemodynamically instable for 24 hours requiring intravenous pressor agents (dobutamine or dopamine upper than 5mcg/kg/min, phenyleprine  upper than 1mcg/kg/min); receiving continuous sedation and mechanical ventilation; have any progressive neuromuscular disease such as amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, myasthenia gravis, or other neuromuscular disorder that would interfere with responding to inspiratory muscle training; have an anticipated life expectancy under 12 months; have a core temperature  above 38.5°C; have a spinal cord injury above T8 and any skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs; using any type of home mechanical ventilation support prior to hospitalization; body mass index upper than 40 kg/m2; require continuous sedative or analgesic agents that will depress respiratory drive or the ability to follow commands; excessive secretions (requiring suctioning more than once every hour).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-5q24zh	Effect of Aerobic Training on Blood Pressure Levels of Hypertensive Subjects	Recruiting	Intervention	2015-08-28	<NULL>	<NULL>	600	Effects of Aerobic High Intensity Training on Blood Pressure Levels of Resistant Hypertensive	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Laboratório de Estudos do Treinamento Físico Aplicado à Saúde	Programa Associado de Pós-Graduação em Educação Física UPE/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-5q24zh	<NULL>	Age between 40 and 60 years; men or women; body mass index under 30 kg / m²; able to participate in exercise; no regular physically active in the last 4 months	Smoking; with history of ischemic stroke or hemorrhagic; or CHD; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-4k7rm6	Pulse oximetry during dental treatment in people with sickle cell disease	Recruiting	Intervention	2015-08-28	<NULL>	<NULL>	604	Pulse oximetry during dental treatment in people with Sickle Cell Disease	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-01-26	Universidade Federal do Rio de Janeiro -UFRJ	Universidade Federal do Rio de Janeiro -UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-4k7rm6	<NULL>	Sixty six teens (from 12 years old) or adults (to 50 years old) with diagnosis and genotype for sickle cell disease established by blood test and medical clearance for dental treatment. Teens or adults with SCD who agree and sign the free and informed consent.Teens or adults with SCD and cognitive ability to answer the questionnaires. Teens or adults with SCD and adequate cognitive comportment whose laboratory and biochemical parameters enable the dental treatment.	"Pregnancy, syndromes or any other condition that requires for care for people with special needs.Adolescents and adults with Sickle Cell Disease who received blood transfusions within 30 days;
Teens or adults with Sickle Cell Disease and heart or lung disease. Teens or adults with Sickle Cell Disease and adenoidal or tonsillar obstruction. Teens or adults with Sickle Cell Disease and serology HIV positive. Teens or adults with Sickle Cell Disease and positive serology for viral hepatitis.Teens or adults with Sickle Cell Disease and hypertension.Teens or adults with Sickle Cell Disease undergoing hormone therapy. Lack of follow-up consultations by adolescents or adults with Sickle Cell Disease during the stages research.Teens or adults with Sickle Cell Disease in whom we could not use the pulse oximeter or reading the oximeter was inconsistent. Teens or adults with Sickle Cell Disease who have not responded the questionnaire on fear / anxiety during dental treatment. Teens or adults with Sickle Cell Disease who decline the survey, retirarando their terms of appointment or consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-39bjm4	The effect of atorvastatin plus aspirin compared with a non-therapeutic substance on the function of the blood vessels and inflammation in HIV patients under treatment presenting a low risk of cardiovascular disease.	Recruiting	Intervention	2015-09-01	<NULL>	<NULL>	606	The effect of atorvastatin plus aspirin versus placebo on the  endothelial function and inflammation in HIV patients under antiretroviral treatment presenting a low risk of cardiovascular risk. A randomized and double blind clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-27	Hospital das Clínicas da Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-39bjm4	<NULL>	HIV patients on antiretroviral use ; both genders , aged between 18 and 60; lower cardiovascular risk than 10 % probability of occurrence of cardiovascular events in 10 years , as measured by the Framingham risk score .	history of hospitalization and  opportunistic infections in the past 90 days; history of chronic liver dysfunction, thyroid dysfunction, autoimmune disease, history of hepatitis B or C; pregnancy or breastfeeding; previous use of statins, fibrates, ezetemibe, omega 3 , aspirin, NSAIDs, oral anticoagulants, interferon, interleukins, growth hormones, immunoglobulins, glucocorticoids or other immunosuppressants; alcohol abuse; previous intolerance to statins and  aspirin; hemophilia; AST and ALT greater or equal 120 IU / L; CPK grater ou equal 167 U / L; muscle trauma or recent surgery performed until four months earlier; history of cardiovascular disease, diabetes, cancer and renal dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:05
RBR-74s6yx	Evaluation of Oral Supplementation With Fish Oil Nutritional Status, Immunity and Inflammation of Patients With Stomach Cancer	Recruiting	Intervention	2015-09-14	<NULL>	<NULL>	610	Impact of Oral supplementation with omega-3 in the Nutritional Status, Immune and Inflammatory Profile of Patients with Gastric Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-20	Instituto Nacional de Câncer	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-74s6yx	<NULL>	"Target sample size is 106 patients.
Patients with gastric cancer. 
Patients in pre-treatment (chemo / radiation / surgery). 
Female or male patients aged between 20 and 65 years. 
Signing of the Informed Consent."	"Patients with Chronic Hepatic Insufficiency  (CHILD-PUGH C); With HIV Virus or Acquired Immune Deficiency Syndrome (AIDS); Congestive Heart Failure Record; Chronic Kidney Disease; Diabetes Mellitus.
Patients undergoing chemotherapy or radiotherapy already started.
Patients with other cancer diagnosis in up to five years ago.
Patients with focal infection or inflammatory disease.
Patients who refuse to sign the consent form for study participation.
Patients who did not tolerate the use of nutritional supplementation or do not use the supplement as prescribed amount i.e. adhesion to the lower supplementation to 80% prescribed amount."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-7rd86h	The effect of elastic and adhesive bandage on labor pain relief	Recruiting	Intervention	2015-05-07	<NULL>	<NULL>	611	Kinesio Taping® on labor pain relief: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-12	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7rd86h	<NULL>	Labouring women with single fetus in vertex position and with good vitality; gestational age from 37 and 42 weeks; spontaneous onset of labor; cervical dilation from 3 to 5 cm; present at least two contractions in 10 minutes interval.	Hospitalization for cesarean sections; preeclampsia; diabetes I, II or gestational; heart disease; hypertension; kidney disease; epilepsy; psychiatric disorders; drug users; previous uterine scar; fetal death; fetal malformation; dermatitis or any infection in the banding application site; known allergy to the material of the bandage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-5n3mtj	Effects of laser therapy on the masseter of children with spastic cerebral palsy	Recruiting	Intervention	2015-09-14	<NULL>	<NULL>	612	Effects of photobiomodulation on the masseter of children with spastic cerebral palsy	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Universidade Cruzeiro do Sul	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5n3mtj	<NULL>	"Cerebral palsy diagnosis of spastic type;
with or without complaints of pain mouth opening; 
difficulty in performing oral hygiene;
utensils locking used for food or for oral hygiene;
trauma story in oral tissues"	Patients diagnosed with cerebral palsy spastic type associated with syndromes or other disabling condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-3tykzt	Effects of continuous aerobic and interval exercise in patientes with heart failure	Recruiting	Intervention	2015-09-17	<NULL>	<NULL>	617	Effects of continuos aerobic and interval trainin in function cardiopulmonary in patients with heart failure: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3tykzt	<NULL>	Cardiologist forward with diagnosis confirmed by clinical and complementary test (echocardiogram); Patient with Functional Class I, II and III HF according to the New York Heart Association (NYHA); 20 ejection fraction to 53% by echocardiography detects the last 6 months; Both genders; Clinical stability; Heart Failure compensated; Spirometry with FEV1 / FVC&gt; 80%; Cardiac pacemaker absence. In addition, patients may not perform training or physical activity elsewhere.	Decompensated heart failure development; CPET or arrhythmias during exercise identified by clinical and / or ECG changes; unstable angina; embolism; acute systemic infection; Lock 3rd degree AV (without pacemaker); pericarditis or acute myocarditis; uncontrolled arrhythmias; ST-segment depression&gt; 2 mm during the year; HF with normal systolic function (ejection fraction&gt; 53%); Class D (red) in the stratification of risk for adverse cardiac events while performing physical exercise; uncontrolled diabetes mellitus; Myocardial Revascularization need for surgical or other procedure; lack of understanding of the activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-54mj4m	Brazilian music effect on heart rate variability in overweight and obese subjects	Recruiting	Intervention	2015-09-17	<NULL>	<NULL>	618	Influence of Brazilian music in the variability of the heart rate of overweight / obesity: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-31	Universidade Presbiteriana Mackenzie	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-54mj4m	<NULL>	"Inclusion criteria: healthy volunteers; male gender; aged between 18 and 35 years; body mass index (BMI) above 24.9 kg / m2. This sample was chosen by recognized experience an increased sympathetic activity.
Individuals will be recruited from advertisements carried in the Mackenzie University and Federal University of Sergipe ."	Exclusion criteria: female gender; volunteers in use of cardiac pacemaker fixed frequency; diagnosis of chronic arrhythmias. Discontinuity criteria: subjects presenting instability in record heartbeat; inability to stand still during the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-6y2srf	Effects of physical exercise and recreational activities in the memory loss of Primary Health Care elderly users.	Recruiting	Intervention	2015-09-30	<NULL>	<NULL>	625	Effects of an aerobic, strength and cognitive training program on the mild cognitive decline of Public Primary Health Care elderly users in Porto Alegre	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-09-11	União Brasileira de Educação e Assistência	União Brasileira de Educação e Assistência	https://ensaiosclinicos.gov.br/rg/RBR-6y2srf	<NULL>	Both genders volunteers; aged 60 years and over; independent at activities of daily living; able to walk independently to the location of training and testing; mild cognitive impairment detected by the Addenbrooke Cognitive Examination (2007 revised version).	Severe psychiatric disorder or traumatic brain injury; use of acetylcholinesterase inhibitors; current substance abuse; important communication deficiencies; simultaneous participation in other research studies; regular practice of physical activity (at least once a week in the last three months); physical therapy treatment in the last three months; physical and functional limitations that might prevent the practice of physical activity; conditions that promote disabilities; visual deficits that prevent reading; recurrent vertigo; uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:06
RBR-97v6f5	Gingival assessment around the teeth in patients using partial dentures	Recruiting	Intervention	2015-10-08	<NULL>	<NULL>	627	Periodontal evaluation in removable partial dentures wearers	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-25	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-97v6f5	<NULL>	Minimum age 18 years. Both genders. Have been met and rehabilitated with maxillary denture and lower removable partial Kennedy Class I. Treated at the service of the Faculty of Dentistry of the Federal University of Rio Grande do Norte.	Over 80 years. Weakened state of health.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-8spkx9	Pain reduction compared postoperative period with the use of morphine versus methadone during anesthesia in cardiac surgery.	Recruiting	Intervention	2015-10-13	<NULL>	<NULL>	630	Postoperative analgesia comparing the Methadone versus Morphine during anesthetic induction in cardiac surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-08-02	Universidade do Sul de Santa Catarina	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-8spkx9	<NULL>	Volunteers undergoing cardiac surgery myocardial revascularization without cardiopulmonary bypass; Both genders; ASA (American Society of Anesthesiologist) III or IV;	Volunteers with a history of illicit drug use; allergy to morphine or methadone; post-operative intubation than 48 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-234nb5	Interdisciplinary intervention with motivational approach in adolescents with overweight and obese	Recruiting	Intervention	2015-06-10	<NULL>	<NULL>	631	Interdisciplinary intervention effectiveness on motivacional approach in lifestyle modification in teenager with overweight and obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-15	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-234nb5	<NULL>	Adolescents between 15 and 18 years with BMI at or above the 85th percentile.	Provide absolute contraindication for physical activity for musculoskeletal, neurological, vascular problems (intermittent claudication), lung and heart; presence of diagnosis of severe psychiatric disorders and / or presence of significant cognitive impairments;pregnant women; diagnosis of Diabetes mellitus type I.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-3czhsf	Oral health and mastication in patients with Parkinson’s disease	Recruiting	Observational	2015-10-14	<NULL>	<NULL>	633	Oral health and chewing function in patients with Parkinson’s disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2012-11-01	Universidade Estadual de Campinas - Faculdade de Odontologia de Piracicaba	Universidade Estadual de Campinas - Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3czhsf	<NULL>	"Case group: volunteer with Parkinson&apos;s disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses.
Control group: volunteers without Parkinson&apos;s disease; both genders; age over 60 years; edentulous or partially dentate; with and without removable dental prostheses."	"Case group: volunteers should not have neurodegenerative disease, except for Parkinson&apos;s disease; and should not have not neurological disorders in which parkinsonism comprises the clinical condition.
Control group: volunteers should not have Parkinson&apos;s disease or other neurodegenerative disease; they should not have neurological disorders in which parkinsonism comprises the clinical condition."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-9jv27c	Effects of a treatment performed with elastic tubings on heart, capacity of exercise and  muscle strength in pulmonary disease	Recruiting	Intervention	2015-10-15	<NULL>	<NULL>	635	Effects of a Resistance Training performed with elastic tubings on cardiac autonomic modulation, cardiopulmonary functional capacity and peripheral muscle strength in Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-21	Universidade Federal de São Paulo	Universidade Estadual de São Paulo - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9jv27c	<NULL>	COPD diagnosis; absence of cardiovascular diseases; absence of neuromuscular or skeletal reported diseases; absence of contraindications or any impediment to completion of the experimental protocol	"Individuals who do not produce at least 95% of sinus beats in the time series of intervals between beats will be deleted 
consecutive heart used in the analysis of heart rate variability; individuals as you do not complete the protocol experimental and who present clinical instability during the treatent"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-33gm3k	Study of the effect of inspiratory muscle training on endothelial function, autonomic control, exercise capacity of life in patients with pulmonary hypertension.	Recruiting	Intervention	2015-10-22	<NULL>	<NULL>	636	Study of the effect of inspiratory muscle training on endothelial function, autonomic control, exercise capacity of life in patients with pulmonary hypertension.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-12-03	Irmandade Santa Casa de Misericórdia de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-33gm3k	<NULL>	Target sample:32 patients. Patients with pulmonary hypertension confirmed by right heart catheterization; the patient must be over 18 years; patients belonging to group I of pulmonary hypertension; patient in  functional class II or III of world health organization; patients with specific drug treatment for pulmonary hypertension stable for at least three months; patients willing to complete the training; patients with inspiratory muscle strength less than 70% predicted.	Patients using oxygen; patients with significant musculoskeletal disorders, intermittent pain; cognitive or neurological deterioration; patients with psychiatric-psychological disorders that may interfere in the understanding of the protocol; patients with a history of moderate or severe chronic lung disease; patients with hemodynamic instability; unstable angina or uncontrolled cardiac arrhythmia; patients who were hospitalized in the last three months; patients who participated in supervised exercise programs in the past three months; patients with inspiratory muscle strength more than 70% predicted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:07
RBR-5xqfds	Respiratory support during physical activity in Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2015-10-31	<NULL>	<NULL>	644	Effects of two ventilatory support modalities on exercise tolerance and dynamic hyperinflation in Chronic Obstructive Pulmonary Disease	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-05	Hospital Universitário Maria Aparecida Pedrossian - HUMAP / EBSERH	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-5xqfds	<NULL>	Patients of both sexes;age between 40 and 75 years; patients with COPD stages 2,3 and 4 according to the panel GOLD criteria, which are exacerbation-free for at least two months, in regular use of prescription drugs; sinus rhythm; the evaluated patients should be able to perform spirometry and cardiopulmonary exercise testing; fall of CI&gt; 150 mL from baseline at the end of incremental exercise testing.	Recent Myocardial Infarction (less than 6 months), unstable angina, complex ventricular arrhythmia with hemodynamic instability; continuous oxygen therapy need or SaO2 &lt;90% at rest; Atrial Fibrillation chronic; inability to ambulation by neuromuscular, orthopedic or psychological limitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-9wch5m	Evaluation of two alpha-tocopherol capsules effect on maternal and child vitamin E levels	Recruiting	Intervention	2015-10-31	<NULL>	<NULL>	646	Supplementation with alpha-tocopherol on the nutritional status in vitamin E	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade Federal do Rio Grande do Norte (Centro Cordenador)	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9wch5m	<NULL>	Lactating women; normal delivery; term delivery; aged 18 to 40 years.	Women with any clinical sign of disease; infections; syphilis; HIV; gastrointestinal diseases; liver disease; heart disease; diabetes; hypertension; cancer; mental disorder; twin pregnancie; newborn with fetal malformations; history of abortion; use of antithrombotics; use of supplements containing vitamin E during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-5v5bvw	Chewing in Alzheimer&apos;s Disease	Recruiting	Observational	2015-11-09	<NULL>	<NULL>	649	Chewing function in Alzheimer&apos;s Disease	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-12-06	Faculdade de Odontologia de Piracicaba - UNICAMP	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-5v5bvw	<NULL>	"Experimental group: elderly patients with mild Alzheimer&apos;s Disease, totaly or partially edentulous, removable prosthesis wearers.
Control Group: elderly patients with the absence of any type of dementia, totaly or partially edentulous, removable prosthesis wearers."	"Experimental group: the presence of cognitive-behavioral disease different from Alzheimer&apos;s dementia, motor disturbances which make impossible appliying the tests, presence of signs and symptoms of bruxism.
Control group: presence of any kind of dementia or cognitive behavioral disease, movement disorders which make impossible appliying the tests, presence of signs and symptoms of bruxism."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:08
RBR-8g2n7y	Pregnancy and intervention to avoid prematurity	Recruiting	Intervention	2015-12-29	<NULL>	<NULL>	661	Quarenta Semanas: Innovative Intervention in Prenatal Care for Reduction of Prematurity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Fundação Oswaldo Cruz	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-8g2n7y	<NULL>	They shall include all pregnant women who accept participate in the research performing prenatal clinics in four randomized clinics after signing the Consent Form . One copy of the consent form  will be provided for all participants.	Pregnant women under 18 and with twin pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-28s4hz	Complementary Therapies to reduce stress  and anxiety and to improve quality of life	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	663	Applicability of Complementary Therapies to reduce pain, stress, anxiety and improving quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-28s4hz	<NULL>	"•	Inclusion Criteria: The patients who are treated by the ITIO Reiki Clinic between June and September of 2015 will be invited and 90 people will be randomized (80% power and 95% confidence interval), which have middle and  high level of stress score on the Stress Symptoms List (LSS)"	"•	Exclusion Criteria: pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressants or other energy therapies to manage stress and anxiety. Those who are receiving psychological therapy, however, won’t be excluded and will be oriented to continue such treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-74jtvm	Assessing the effect of a web-based psycotherapy for alcoholists	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	664	Web-based brief psychotherapies for users alcohol and other drugs	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-01	Conselho Nacional de Desenvolvimento Científico e Tecnológico	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-74jtvm	<NULL>	male; alcohol dependent diagnosis; between 18 and 65 years; not be abstinent during 30 days prior to admission to treatment	abuse or dependent diagnosis of other drugs, exception of tobacco; have participated in specialized treatment for alcohol and other drugs problems in the last three months; meet criteria for severe mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:09
RBR-2rzt5c	Effect of the use of the anchoring system for patients with chronic peripheral vestibular	Recruiting	Intervention	2014-10-08	<NULL>	<NULL>	668	Effects of the use of the anchor system in the rehabilitation of balance in individuals with chronic peripheral vestibular disorder: randomized blind controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo - USP	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo - USP	https://ensaiosclinicos.gov.br/rg/RBR-2rzt5c	<NULL>	"Eligibility criteria fall within individuals of both sexes , aged 50 years, suffering from chronic peripheral vestibular disease with presence of dizziness and decreased body balance, and nonspecific lightheadedness or feeling dizzy, and peripheral etiology and daily occurrence , weekly, monthly for at least three months , in which the symptoms of vertigo , dizziness , postural instability of vestibular origin , are not responding positively to conventional RV , which includes the reorganization of the VOR .
Will be classified as patients who do not respond positively to RV , those who remain with otoneurology symptoms for more than six months after the start of the intervention , no clinical improvement observed .
The diagnosis of chronic peripheral vestibular disease will be confirmed at the Otolaryngology Department of Ophthalmology , Otorhinolaryngology and Head and Neck Surgery , Hospital das Clinicas, Faculty of Medicine of Ribeirão Preto, University of São Paulo - FMRP - USP."	Exclusion criteria from the survey include: patients who are using drugs (benzodiazepines and anticonvulsants) acting on the balance, calcium channel blockers (cinnarizine and flunarizine), plus motor, visual or cognitive restrictions that prevent the realization of and reviews proposed intervention, as well as with systemic diseases without drug therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-39mpct	Assessment of health around implants in patients rehabilitated with Removable or Fixed  Prostheses on Implants	Recruiting	Intervention	2016-01-04	<NULL>	<NULL>	669	Peri Implant Health Assessment in patients rehabilitated with Overdentures and Full-arch Fixed Prosthesis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-05-26	Hospital Universitário Onofre Lopes	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-39mpct	<NULL>	Bimaxillary edentulous; use of double dentures for at least one year; rehabilitation with conventional denture bimaxillary in UFRN; sufficient bone height for implant placement of at least 9,00mm in the mandibular arch.	Diabetes; smoking; osteoporosis; immune deficiency or anticoagulant therapy; patients with neurological diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-8ngvnn	Pulpectomy in primary teeth: randomized controlled clinical trial evaluation	Recruiting	Intervention	2016-01-05	<NULL>	<NULL>	670	Pulpectomy in primary teeth: randomized controlled clinical trial evaluation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-25	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8ngvnn	<NULL>	Eligible patients will be select if they present:primary teeth with at least two years of permanence in mouth; teeth with radiographic changes suggesting  apical periodontitis either in root and/or furcation area; cavity that allows restoration with suitable sealing;  and teeth without any previous treatment pulp. Patients should have good systemic health, and the data on health history will be recorded.	Will be excluded from the study: teeth with less than two tears of permanence in the mouth; teeth showing root resorption equivalent to 2/3 or more; presenting radiographic disruption of pericoronal bag of the permanent teeth; primary teeth endodontically treated  in a previous session that not present remission of symptoms;teeth with non-appropriate restorative conditions. Patients with any changes to general, are not included in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-5smzhp	Low-level laser effect on the tooth root treatment	Recruiting	Intervention	2016-01-06	<NULL>	<NULL>	671	Effect of Photobioestimulation therapy on pain after Endodontic treatment: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-14	Universidade Federal do Amazonas (UFAM)	Universidade Federal do Amazonas (UFAM)	https://ensaiosclinicos.gov.br/rg/RBR-5smzhp	<NULL>	Adult patients; with endodontic treatment indication in permanent lower molars; diagnosed with irreversible pulpitis; have contact number to be able to perform the postoperative evaluations	Pregnant patients; administering any medication when treatment; immunocompromised; with hypersensitivity to non-steroidal anti-inflammatory drugs; patients who have teeth with endodontic complications (calcifications, external or internal resorption, partial formation of apical summit with dental drilling, with longitudinal or vertical fractures and severe periodontal disease); patients who can not have endodontic treatment completed in the same session; Patients who for any reason can not be contacted by phone for the evaluation of pain after endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-2w55vq	Study to evaluate the occurrence of Dengue in areas with higher concentrations of cases in Brazil	Recruiting	Observational	2016-01-06	<NULL>	<NULL>	674	An epidemiological surveillance study to evaluate the incidence of Dengue in brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-02-17	GlaxoSmithKline Biologicals	GlaxoSmithKline Biologicals	https://ensaiosclinicos.gov.br/rg/RBR-2w55vq	<NULL>	Written and signed informed consent; male or female at least 6 months of age at the time of enrollment; subject and/or subject’s parent(s) who the investigator believes can comply with the requirements of the protocol and Subject who plans, at the time of enrollment, to remain at same residence/study area during the one year study period	Child in care; participation (current or planned) in another epidemiological study or in a clinical trial that would conflict with the current study, based on investigator’s judgement and terminal illness or severe mental incapacity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-6cvprm	Effects of two training programs: aerobic and resistance in muscle strength, physical fitness and muscle pain in participants with blood pressure, abdominal obesity, cholesterol and glucose levels impairments	Recruiting	Intervention	2016-01-12	<NULL>	<NULL>	679	Effects of two periodized training programs: aerobic interval and resistance training in isokinetic strength, physical fitness and clinical parameters on Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6cvprm	<NULL>	Sedentary men; between 35 and 60 years; diagnosed with Metabolic Syndrome	use of drugs or medications, except those used to control the risk factors of Metabolic Syndrome; presenting amenorrhea; inflammation and or infection; episode of muscle tendon or osteo articular injury in the upper, lower limbs and or spine in the last three months; respiratory diseases; neurological disorders and cardiovascular disease at high risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-4m42nq	A study of eltrombopag in combination with azacitidine for subjects with low platelet counts due to intermediate 1, intermediate 2 or high risk Myelodysplastic Syndromes.	Recruiting	Intervention	2016-01-15	<NULL>	<NULL>	684	TRC112121 A phase III, randomized, double-blind, placebo-controlled, multi-center eltrombopague or placebo in combination with azacitidine in patients with Myelodysplastic Syndrome with IPSS intermediate-1 classification, intermediate-2 and high-risk.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2014-05-23	GlaxoSmithKline Brasil	GlaxoSmithKline	https://ensaiosclinicos.gov.br/rg/RBR-4m42nq	<NULL>	Myelodysplastic Syndromes risk ranked at Intermediate 1, intermediate 2 or high according to IPSS;At least one platelet count lower than 75 Gi/L;Eastern Cooperative Oncology Group(ECOG) Status 0-2.;  Adequate baseline organ function	Previous treatment with hypomethylating agent or induction chemotherapy for MDS;History of treatment with eltrombopag, romiplostim or other TPO-R agonists;Previous allogeneic stem-cell transplantation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:10
RBR-52pq3b	Bed bath with tub / basin and bath bag: micro-biological case-control and cost evaluation	Recruiting	Intervention	2016-01-22	<NULL>	<NULL>	689	Conventional Bath bed and Bath Bag: case-control microbiological, cost evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Universidade Estadual Paulista Julio de Mesquita Filho	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-52pq3b	<NULL>	dependence on the nursing team; impaired physical mobility; bedridden in the ward admission; up to 48 hours of hospitalization.	partial dependence on the nursing team; They are not bedridden; show on mechanical ventilation; infectious disease of skin and soft tissue (cellulitis; erysipelas; eczema); skin ulcers; pressure; venous; infectious or tumor; previous use of antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-2xj368	Influence of resveratrol (grappe seed extract) on heart beats at rest and during exercise in adults with hypertension.	Recruiting	Intervention	2016-01-22	<NULL>	<NULL>	691	Effects of resveratrol supplementation on heart rate variability in adults with hypertension	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-03	Instituto Federal de Educação, Ciência e Tecnologia do Sudeste de Minas Gerais	Fabianne Magalhães Girardin Pimentel Furtado	https://ensaiosclinicos.gov.br/rg/RBR-2xj368	<NULL>	Adults of both genders, aged between 35-70, with hypertension.	"No additional orthopedic deficiencies impairing ambulation
Uncontrolled high blood pressure 
Diabetes or cardiomyopathy
Regular wine or grape juice drinkers
People who exercise regularly 
People with intolerance to resveratrol"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-8bxdd3	Use of positive pressure face mask as a resource treatment in postoperative cardiac surgery	Recruiting	Intervention	2016-01-27	<NULL>	<NULL>	694	Analysis of the use of noninvasive ventilation in patients after cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-10-09	Universidade Federal de Sergipe	Universidade Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-8bxdd3	<NULL>	Inclusion criteria include: patients admitted to the Hospital Charitable Foundation Surgery in preoperative procedure for cardiac surgery (valvuloplasty or valve replacement and / or CABG); both sexes aged 20 and 70 years; absence of psychiatric condition, cognitive decline or dementia influencing the communication process; absence of neuromuscular or musculoskeletal disorder or recent unresolved that may affect your ability to walk or mobility.	Patients will be excluded conditions : contraindications to the use of therapies with noninvasive positive pressure as decreased level of consciousness , ineffective cough , airway obstruction , abdominal distension , vomiting , upper gastrointestinal bleeding , hemodynamic instability , coronary syndrome acute , complex arrhythmias , facial trauma , surgery , esophageal barotrauma undrained ; patients requiring mechanical ventilation , invasive for over 24hrs , patients who refuse to sign the consent form or refuses to perform the treatment , patients in the control group at any time of the present study indicate ventilatory support both invasive and non -invasive clinically by dyspnea characterized by: increased respiratory rate &gt; 25 bpm , paradoxical pattern , use of accessory muscles , runs and fall of oxygen saturation ; surgical complications that impede patient participation in research .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-4nwmk4	Evaluation of atraumatic restorative treatment (ART) in the family health strategy of Teresina, Piauí	Recruiting	Intervention	2016-01-28	<NULL>	<NULL>	697	Evaluation of atraumatic restorative treatment (ART) in the family health strategy of Teresina, Piauí	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	UNIVERSIDADE FEDERAL DO PIAUÍ	Profa Dra Marcoeli Silva de Moura	https://ensaiosclinicos.gov.br/rg/RBR-4nwmk4	<NULL>	good general health, present dentin caries lesion in vital primary teeth without pain symptoms or signs of pulp envelopment	Deep cavities, presence of fistula, pulp envelopment or mobility of the selected tooth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-56p5mj	Effectiveness analysis of very small-bore catheters for drainage of malignant pleural effusions	Recruiting	Intervention	2016-01-28	<NULL>	<NULL>	698	Effectiveness analysis of very small-bore catheters for drainage of malignant pleural effusions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-16	Centro Universitário da Faculdade de Saúde, Ciências Humanas e Tecnológicas do Piauí	Nabor Bezerra de Moura Júnior	https://ensaiosclinicos.gov.br/rg/RBR-56p5mj	<NULL>	"Patients with malignant pleural effusion requiring chest drainage
Agreement  with the research and signing of the Informed Consent Form."	"Patients less than 18 years-old
Empyema
Post-operative period of thoracic surgery
Patients using sedatives and / or mechanical ventilation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-78h48d	Aquatic physiotherapy in pain, daily activities and quality of life in older people with knee Osteoarthritis	Recruiting	Intervention	2016-01-29	<NULL>	<NULL>	700	Effectiveness of aquatic physiotherapy in the perception of pain, functional capacity and quality of life of older adults with knee Osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-23	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-78h48d	<NULL>	Volunteers diagnosed with knee osteoarthritis; both genders; age above 60 years.	Volunteers with severe cardiac and respiratory diseases; fibromyalgia; epilepsy; knee replacement or hip; inability to walk independently; otitis; sores on the skin; mycoses; hydrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:11
RBR-3tv5mr	Postpartum depression and Emotion Recognition: clinical study of the acute effects of Oxytocin	Recruiting	Intervention	2016-01-29	<NULL>	<NULL>	703	Postpartum Depression and Facial Expression Recognition: clinical, randomized study involving the acute effects of Oxytocin	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2015-11-01	Faculda de Medicina de Ribeirão Preto	Mariana Fortunata Donadon	https://ensaiosclinicos.gov.br/rg/RBR-3tv5mr	<NULL>	Check shall be the initial inclusion criteria (age above 18 years, post-pregnancy postpartum (20-45 days after the baby&apos;s birth), number of previous pregnancies) and those that meet the criteria will be invited to participate in the study.	"mothers with absence of diagnosis of depression post partum;
age under 18
post-pregnancy than in the postpartum period (20-45 days after the baby&apos;s birth;
mothers with birth complications"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-8cchby	Breathing exercises before surgery abdominoplasty	Recruiting	Intervention	2016-02-01	<NULL>	<NULL>	706	Phyisical therapy preparation in respiratory complications in abdominoplasty Prevention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cchby	<NULL>	Feminine gender; Body Mass Index between 20 and 30 kg/m2; with abdominal deformity type III Nahas; and type B Nahas.	Obstructive or restrictive respiratory disease; with abnormal chest x-ray; smokers; those with systemic diseases; subject to previous abdominal surgery; with supra-umbilical scars and post bariatric surgery with great weight loss; not carrying out the pre-breathing exercise operative as directed; or not attending the physical therapy session for the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-5zpphs	Impact of hidrotherapy and dry land exercises in daily activities and quality of life of older people with knee osteoarthritis	Recruiting	Intervention	2016-02-16	<NULL>	<NULL>	714	Impact of physiotherapy aquatic and dry land exercise in functional capacity and quality of life of older adults with knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-02	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5zpphs	<NULL>	Volunteers diagnosed with knee osteoarthritis; both genders; age above 60 years.	Volunteers with severe cardiac and respiratory diseases; fibromyalgia; epilepsy; knee replacement or hip; inability to walk independently; otitis; sores on the skin; mycoses; hydrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-45ywtg	Multiprofessional Program for Obesity Treatment in adolescents	Recruiting	Intervention	2016-02-19	<NULL>	<NULL>	716	Multidisciplinary Program for Obesity Treatment in Adolescents: efficacy trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-08-01	Universidade Estadual de Maringá	Fundação Araucária	https://ensaiosclinicos.gov.br/rg/RBR-45ywtg	<NULL>	Adolescents classified as overweight or obese according to the criteria established by Cole et. al (2000); concordance of the adolescent and his/her parents/guardians in participating integrally in the interventions.	The exclusion criteria will be: endocrine and metabolic diseases previously diagnosed and informed to the pediatrician; long-term alcohol consumption; use of glucocorticoids and psychotropics which could affect appetite regulation; less than 70 % compliance in all multidisciplinary interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-27kqv5	Comparison of a training videogame with conventional physiotherapy on postural control and quality of life of patients with Parkinson&apos;s disease	Recruiting	Intervention	2016-02-25	<NULL>	<NULL>	718	Effects of physical therapy assisted by Kinect system in postural control, cognition and quality of life of patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-04-14	Faculdade de Medicina da Universidade de São Paulo.	Faculdade de Medicina da Universidade de São Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-27kqv5	<NULL>	Thirty-two participants will be selected between 50 and 80 years; diagnosed with idiopathic Parkinson&apos;s disease performed by specialized neurologists in extrapyramidal diseases according to the criterion of the Brains Bank of the UK Parkinson&apos;s Society; stages I to III of the Hoehn and Yahr scale; treated with levodopa and/or their synergists; do not present other neurological or orthopedic diseases diagnosed; do not present signs of dementia assessed using the Mini Mental State Examination with cutoff score according to educational level; with visual acuity and auditory normal or corrected; no prior experience with the Kinect system; have not participated in a rehabilitation program in the last two months and sign the Term of Consent of the study.	Patients will be excluded that during the period of the study present any clinical change that makes it impossible to perform physical exercises in standing position as cardiorespiratory; orthopedic or neurological disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-8qj4p5	Evaluation of blood pressure, blood flow fetal and neonatal outcome with the use of a phosphodiesterase type 5 inhibitor in the treatment of women with preeclampsia	Recruiting	Intervention	2016-02-26	<NULL>	<NULL>	720	Hemodynamics and perinatal assessment of phosphodiesterase type 5 inhibitors in pregnant women with preeclampsia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-8qj4p5	<NULL>	Pregnant women between 24-33 weeks. Diagnosis of pregnancy induced hypertension, defined as diastolic blood pressure equal to or greater than 90 mmHg and proteinuria above 0.3 g in 24 hours. Admitted at least 24 hours. Signing an informed consent form	Twin pregnancy. Diabetes. Provided hypertension and other chronic diseases. Serious fetal malformations. Fetal vitality of changes indicating the termination of pregnancy (reverse diastole umbilical artery, abnormal ductus venosus, severe oligoâminio, GMP below 6. Maternal changes indicating the termination of pregnancy (Eclampsia, HEELP syndrome, severe renal impairment). Patient use of magnesium sulfate, erythromycin, ketoconazole, itraconazole, or other antiretroviral drugs that have interaction with sildenafil. Refusal to sign the post informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:12
RBR-43sjz7	Benefits of physical therapy and cognitive training in the non-motor symptoms (sleep and cognition) in patients with Parkinson&apos;s disease	Recruiting	Intervention	2016-02-26	<NULL>	<NULL>	723	Effectiveness of physical therapy associated to cognitive training in the improvement of non-motor symptoms in patients with Parkinson´s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-43sjz7	<NULL>	"Medical diagnosis of Parkinson&apos;s disease, according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria)
Individuals over 50 years. Not  institutionalized. Mini Mental score that does not characterize cognitive impairment. Hohen Yahr between 1.5 and 3.0. Which accept to participate of the project and sign the consent term according to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (CNS)."	Individuals who perform another therapeutic treatment beyond medication, that has change in medication during the study or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive or understanding deficits. Change in the stabilization of the antiparkinsonian medication doses throughout the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-6wvb5c	Effects of electrical stimulation of the quadriceps muscle strength and walking capacities in patients with chronic kidney disease on hemodialysis	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	724	Peripheral effects of electrical stimulation on peripheral muscle strength and exercise capacity in patients with chronic kidney disease on hemodialysis	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2015-08-11	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6wvb5c	<NULL>	Patients with CKD diagnostic who are on dialysis regularly for at least 6 months,  stable and under medical supervision; patients without: uncontrolled hypertension, recent ischemic heart disease (3 months or less), unstable angina and severe cardiac arrhythmias; patients without diseases that limit the electrical stimulation protocol (respiratory, orthopedic and / or neurological); patients who do not do any form of physical training or who have been held for more than six months.	Inability to perform any of the study assessments (lack of understanding or collaboration); recent decompensation of the clinical picture with or without hospitalization; presence of chronic obstructive pulmonary disease (COPD or emphysema), musculoskeletal diseases that impede the realization of assessments and training protocol, uncontrolled hypertension, recent ischemic heart disease (3 months or less), unstable angina and severe cardiac arrhythmias; abnormal sensitivity in the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5zpnnt	Effects of weight training program versus aerobic training on blood values, oxLDL and body weight individuals with metabolic abnormalities	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	727	Effects of a resistance training program periodized versus aerobic interval in functional parameters, lipid and oxLDL of individuals with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Ciências e Tecnologia	Faculdade de Ciências e Tecnologia	https://ensaiosclinicos.gov.br/rg/RBR-5zpnnt	<NULL>	Having metabolic syndrome; not having practiced regular physical activity or have performed strength training in the last six months.	Make use of drugs or medicines; present amenorrhea; presence of inflammation and / or infection process; episode muscle tendon or osteoarticular lesions in the upper and lower limbs and / or spine; respiratory diseases, neurological and cardiovascular risk or high.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5sb8sb	Randomized clinical trial of three materials after partial caries removal in primary teeth	Recruiting	Intervention	2016-03-01	<NULL>	<NULL>	731	Randomized clinical trial of three pulp capping materials after partial caries removal in primary teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Faculdade de Odontologia de Bauru	Thais Marchini de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-5sb8sb	<NULL>	The sample inclusion criteria comprise children between 5-9 years old of both genders, that do not present systemic diseases; no allergic reaction history to the latex rubber dam and / or local anesthetic; with at least one or two primary molars (upper / lower) committed by deep decay that reaches two thirds of the dentin; occlusal and / or occlusal-proximal caries; with lack of sensitivity and / or spontaneous pain; absence of pulp exposure; absence of excessive mobility; absence of fistula or abscess; Radiographic absence of internal and external resorption; Radiographic absence of root resorption greater than 1/3 of the root; Radiographic absence of radiolucent image in the periapical region and furca that might indicate the presence of irreversible pulpitis or pulp necrosis; gum apparently healthy place; and tooth restorative possibility (BRESSANI et al, 2013;. Petrou et al, 2013;. SCHWENDICKE et al, 2015.).	Exclusion criteria comprise presence of systemic diseases; history of allergic reaction to the latex rubber dam and / or local anesthetic (BRESSANI et al, 2013;. SCHWENDICKE et al, 2015.).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-9p3hdp	Resin restorations assessment made ??by applying differently the adhesive system	Recruiting	Intervention	2016-03-02	<NULL>	<NULL>	733	Adhesion of composite resin direct restorations with different protocols of adhesive system application – a clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-16	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9p3hdp	<NULL>	Age between 18 and 60 years; both genders; need for Class I and II restorations in premolars and/or molars, presence of at least three dental elements to be restored whose antagonist teeth are present; presence of at least 20 teeth in occlusion.	Holders or removable orthodontic appliances; holders of bruxism; pregnant or breast-feeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-8xg8g8	Evaluation of Mastication and Bite force in complete denture wearers	Recruiting	Intervention	2016-03-02	<NULL>	<NULL>	734	Influence of Occlusion guidance and Mandibular ridge resorption on Masticatory performance and Ability, and Maximum occlusal force in complete denture wearers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-05	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-8xg8g8	<NULL>	Adults ndividuals; both genders; bimaxillary edentulous; aged 40 to 90 years, of both genders; users or non-conventional complete dentures; requiring preparation or replacement of dentures; receptives; mentally agiles; good understanding of speaking Portuguese; mandibular ridges with normal or resorbed volume; normal amount and quality of saliva	Debilitating systemic diseases; pathological changes in the oral tissues; neuromuscular impairment; temporomandibular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-27sdv5	Anti-human globulin Rh D drug from effectiveness from review after vaccination in women with postpartum negative factor blood and with complications risk in newborns	Recruiting	Intervention	2016-03-02	<NULL>	<NULL>	735	Evaluation of clinical efficacy of Kamrho-D® drug (anti-human globulin Rh D - Panamerican) in postpartum women Rh negative immunization, coombs indirect negative and sensitization risk	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2013-02-01	Hospital São Lucas da PUC/RS (Centro Coordenador)	LAL Clinica Pesquisa e Desenvolvimento Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-27sdv5	<NULL>	"Postpartum women who agreed to participate and sign and date back to the Informed Consent (IC);
Postpartum women over the age of 18;
negative Rh postpartum women, Coombs negative indirect analyzed by gel agglutination method, whose newborn is Rh +."	"Simultaneously be participating or have participated in another clinical study within the last 12 months;
postpartum women allergy sufferers to any of the components of the formula;
postpartum women with IgA deficiency history or story to IgA antibody;
postpartum women with a history of autoimmune hemolytic anemia with pre-existing risk with hemolysis or hemolysis;
postpartum women who have positive Indirect Coombs test at the beginning of treatment;
postpartum women who have given birth to negative Rh fetuses;
postpartum women with abnormalities of the coagulation system;
Patients who used elaborate vaccines with live pathogens in the last 03 months or will do during the study;
Patients with pre-natal clinical diagnosis of liver disease and / or severe nephropathy.
At the discretion of the Principal Investigator of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-5bb65v	Rating of ventilation with two pressure levels when the patient exhales in patients with severe inflammatory disease in the lung.	Recruiting	Intervention	2016-03-03	<NULL>	<NULL>	736	Short-term effects of mechanical ventilation with two levels of PEEP (BiPEEP) in patients with Acute Respiratory Distress Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Centro Universitário Metodista - IPA	Complexo Hospitalar Santa Casa de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5bb65v	<NULL>	Mechanically ventilated patients for more than 24 hours; presenting hemodynamically stable (mean arterial pressure between 70 and 120 mm Hg); PaO 2 / FiO 2 100-300; diffuse infiltrates on chest radiograph.	Patients with a history of pulmonary emphysema; presence of barotrauma; chest tube; undrained pneumothorax.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-6n3dzz	Exercise and ventilatory support in patients with Chronic Obstructive Pulmonary Disease after inspiratory muscle training	Recruiting	Intervention	2016-03-04	<NULL>	<NULL>	737	Endurance associated with noninvasive ventilation in patients with chronic obstructive pulmonary disease after inspiratory muscle training	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-13	Fundação Universidade Federal de Mato Grosso do Sul	Hospital Universitario Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-6n3dzz	<NULL>	Patients of both sexes; aged between 40 and 80 years diagnosed with Chronic Obstructive Pulmonary Disease Class III and IV (severe to very severe) according to the Global Initiative for Obstructive Lung Disease criteria (GOLD). Exacerbation free in the 4 weeks prior to testing; absence of cardiovascular disease; arthritis; asthma; pulmonary hypertension; diabetes or musculoskeletal disorders that prevent the achievement of exercise tests.	Patients younger than 40 and older than 80 years who present cardiovascular changes during the exercise test. Those who do not attend at least 80% of the stages of inspiratory muscle training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-78qtwy	Effects of treadmill physical exercise in women with polycystic ovaries	Recruiting	Intervention	2016-03-07	<NULL>	<NULL>	739	Effects of continuos and interval aerobic physical training  in women with polycystic ovary syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-11-11	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-78qtwy	<NULL>	Volunteers with PCOS between 18 to 39 years old; body mass Index between 18 and 39.9 kg/m2 (normal overweight and obesity grades I and II); Do not practice regular physical activity.	Presence of systemic disease that contraindicate to physical activity; presence of disabling musculo-skeletal disorders; use of drugs that interfere with the hypothalamic-pituitary-ovarian-axis and hormonal contraceptives; smoking, pregnant and volunteers who are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:13
RBR-2xcd99	Gastrointestinal and lung cancer, effects of the fish oil intake on nutritional status, quality of life and imunnometabolic outcomes	Recruiting	Intervention	2016-03-10	<NULL>	<NULL>	745	Gastrointestinal and lung cancer, effects of the fish oil intake on nutritional status, quality of life and imunnometabolic outcomes	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-02	Universidade Federal de Santa Catarina - UFSC	Centro de Pesquisas Oncológicas de Florianópolis - CEPON/SC	https://ensaiosclinicos.gov.br/rg/RBR-2xcd99	<NULL>	Individuals with 19 years or older, histopathologic diagnosis of gastric cancer, or colorectal or anal canal or non-small cell lung cancer, ability to start chemotherapy in co-participant institution (CEPON).	"Prior chemotherapy, inability to
oral intake, diagnosis of infectious or inflammatory disease, be allergic to fish and / or derivatives, be pregnant, treatment with statins, ??use of fish oil and/or another supplement containing omega-3 or other polyunsaturated fatty acid in the six months
prior to the study period, continued use of supplements containing antioxidants."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-6pmfz8	Acute Lymphoblastic Leukemia treatment protocol for children and adolescent	Recruiting	Intervention	2016-03-11	<NULL>	<NULL>	746	Acute Lymphoblastic Leukemia treatment protocol for children and adolescent GBTLI ALL-2009	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2010-01-01	Sociedade Brasileira de Oncologia Pediátrica (SOBOPE)	Centro Infantil Boldrini (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-6pmfz8	<NULL>	"Will be eligible for this study all patients aged &lt; 18 years (up to 17.99 years ) diagnosed with previously untreated ALL, with emphasis on no steroid use.
The requisites for proper leukemia diagnostic profile are: cytomorphological analysis, cytochemistry, immunephenotyping spinal fluid profile, cytogenetics and molecular biology
All patients and their legal representatives should be informed about the investigative nature of this study and must sign and provide free and informed consent in accordance with institutional and federal recommendations."	"Without Informed Consent Term.
ALL patient aged &gt; 18 years.
Prior use of corticosteroids.
Not confirmed the ALL diagnosis, after Central review."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-93gkd4	Efficacy and safety of Eslicarbazepine Acetate (BIA 2-093) as single therapy for patients with newly diagnosed partial-onset seizures - ESL extension study	Recruiting	Intervention	2016-03-11	<NULL>	<NULL>	748	Efficacy and safety of Eslicarbazepine Acetate (BIA 2-093) as monotherapy for patients with newly diagnosed partial-onset seizures: a double-blind, randomized, active-controlled, parallel-group, multicenter clinical trial - open-label ESL extension	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2016-01-04	Instituto de Neurologia de Curitiba	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-93gkd4	<NULL>	Participation in the preceding double-blind study and still ongoing at the time of unblinding; informed consent signature; cooperation and willingness to complete all aspects of the study.	Exclusion from the double-blind study; clinical evaluation of suicidal risk; occurrence of an adverse event; events of alcohol, drug, or medication abuse; relevant clinical laboratory abnormalities; pregnancy or lactating.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-27g66s	Use of diabetes medication to prevent diabetes during pregnancy	Recruiting	Intervention	2016-03-15	<NULL>	<NULL>	752	Prophylactic use of Metformin in Gestational Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-31	Universidade da Região de Joinville - Univille	Hospital Regional Hans Dieter Schmidt Secretaria do Estado de Saúde de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-27g66s	<NULL>	Pregnant women will be diagnosed with GDM selected according to the criteria of the World Health Organization; aged over 18 years; singleton pregnancy; with screening for gestational diabetes mellitus (GDM) in early positive pregnancy; gestational age between 11 and 33 weeks; no pathology that interferes with glucose metabolism; no hypersensitivity to metformin hydrochloride or important drug allergy; history or presence of liver disease; renal or gastrointestinal or other conditions that interfere with absorption; distribution; excretion or metabolism of the drug.	They will be excluded from follow-up losses; intolerance to drugs; desire of the mother and presence of risk to the fetus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-44kg5x	Intralesional treatment for cutaneous leishmanisis	Recruiting	Intervention	2016-03-16	<NULL>	<NULL>	753	Efficacy and safety of intralesional use of meglumine antimoniate in the treatment of localized cutaneous leishmaniasis	<NULL>	2-3, single-arm-study, open	2-3	<NULL>	<NULL>	<NULL>	2015-08-03	Hospital Eduardo de Menezes	Centro de Pesquisa Rene Rachou, Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-44kg5x	<NULL>	volunteers with localized cutaneous form of leishmaniasis; both sexes; with up to maximum of three lesions and area of lesions of not more than 900mm2	"Pretreatment with antileishmanial drugs for less than 6 months;
History of allergy to meglumine antimoniate; Presence of congestive heart failure or cardiac arrhythmia; Medication with potential to cause cardiac arrhythmia; Pregnancy or lactation; Creatinine above 2 mg%"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:14
RBR-42c8wp	Complementary Therapies for stress and anxiety reduction and improving quality of life	Recruiting	Intervention	2016-03-18	<NULL>	<NULL>	761	"Applicability of Complementary Therapies for pain, stress, anxiety reduction
and improving quality of life: Randomized Clinical Trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-30	Escola de Enfermagem da Universidade de São Paulo	Instituto Terapia Integrada e Oriental	https://ensaiosclinicos.gov.br/rg/RBR-42c8wp	<NULL>	Inclusion Criteria: The patients with  medium and high level of stress score on the Stress Symptoms List (LSS)	Exclusion Criteria: pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressant or other energy therapies to manage stress and anxiety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-55mp5z	Comparison of two drugs to prevent nausea and vomiting after surgery for reducing the stomach	Recruiting	Intervention	2016-03-18	<NULL>	<NULL>	762	Palonosetron versus ondansetron for postoperative nausea and vomiting prophylaxis in laparoscopic gastroplasty in morbid obese patients - a randomized controlled noninferiority trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-11-15	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP	https://ensaiosclinicos.gov.br/rg/RBR-55mp5z	<NULL>	Adult patients undergoing elective laparoscopic gastroplasty; both sexes; 20 to 65 years old; physical state I and II according to American Society of Anesthesiology (ASA); body mass index equal or higher than 35 kg/m2	Use of antiemetics for 48 hs before surgery; those with hiatal hernia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-74jbmn	Effect of an oral health promotion intervention in primary health care	Recruiting	Intervention	2016-03-28	<NULL>	<NULL>	765	Implementation and evaluation of an oral health promotion intervention for children aged zero to five years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-74jbmn	<NULL>	It will be included Primary Health Care Centers belonging to the urban area, that have family oral health team working for at least one year, at least 200 children from zero to five years old enrolled, offering postpartum care and childcare. All children enrolled in Primary Health Care Centers aged between 0 and 3 years old will be eligible to participate.	Primary Health Care Centers that are holding other interventions in oral or nutritional health, which have different work process will be excluded. It will be excluded children whose families wish to move in within six months of the baseline study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3q2sdt	A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis	Recruiting	Intervention	2016-03-29	<NULL>	<NULL>	766	CNTO1275AKS3002 - A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(alpha) Refractory Subjects With Active Radiographic Axial Spondyloarthritis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-09-18	LMK Serviços Médicos SS	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3q2sdt	<NULL>	Inclusion Criteria: Participants must have a diagnosis of definite ankylosing spondylitis (AS), as defined by the modified 1984 New York criteria. The radiographic criterion must be confirmed by a central xray reader and at least 1 clinical criterion must be met; Participants must have symptoms of active disease at screening and at baseline, as evidenced by both a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of greater than or equal to (&gt;=4) and a visual analog scale (VAS) score for total back pain of &gt;=4, each on a scale of 0 to 10; Participants with elevated high sensitivity C-reactive protein (hsCRP) level of &gt;=0.300 milligram per deciliter (mg/dL) at screening - Refractory by either lack of benefit or documented intolerance to 1 and no more than 1 anti-TNF(alpha) agent; Inadequate response to at least 2 nonsteroidal anti-inflammatory drugs (NSAIDs) over a 4-week period in total with maximal doses of NSAID(s), or is unable to receive a full 4 weeks of maximal NSAID therapy because of intolerance, toxicity, or contraindications to NSAIDs.; Participants with complete ankylosis of the spine are permitted to be included in the study, but will be limited to approximately 10 percent (%) of the study population	Exclusion Criteria: Participants who have other inflammatory diseases that might confound the evaluations of benefit from the ustekinumab therapy, including but not limited to, rheumatoid arthritis, systemic lupus erythematosus, or Lyme disease - Participants who have received infliximab or infliximab biosimilar, within 12 weeks of the first study agent administration; have received adalimumab, adalimumab biosimilar, or certolizumab pegol within 6 weeks of the first study agent administration; have received etanercept or etanercept biosimilar within 6 weeks of the first study agent administration;  Participants who have ever received golimumab ; Participants who are pregnant, nursing, or planning a pregnancy or fathering a child while enrolled in the study or within 5 months after receiving the last administration of study agent; Participants who have received any systemic immunosuppressives or disease-modifying antirheumatic drugs (DMARDs) other than methotrexate (MTX), sulfasalazine (SSZ), or hydroxychloroquine (HCQ) within 4 weeks prior to first administration of study agent. Medications in these categories include, but are not limited to leflunomide, chloroquine, azathioprine, cyclosporine, mycophenolate mofetil, gold, and penicillamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3dccf6	"A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Avoiding in Adult Participants With Treatment-resistant
Depression"	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	769	"A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant
Depression"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-07-09	Clinica Dr. Norton Sayeg Ltda. EPP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3dccf6	<NULL>	Inclusion Criteria: At the time of signing the informed consent form (ICF), participant must be a man or woman 18 (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age, inclusive - At the start of the screening/prospective observational phase, participant must meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD, the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD, without psychotic features, based upon clinical assessment and confirmed by the Mini- International Neuropsychiatric Interview (MINI) - At the start of the screening/prospective observational phase, participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34 - At the start of the screening/prospective observational phase, participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration, as assessed using the Massachusetts General Hospital – Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records, for the current  episode of depression - The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment For Transferred-Entry Participants - The participant must have completed the double-blind induction phase in ESKETINTRD3001 or ESKETINTRD3002 and must have demonstrated response at the end of that phase (&gt;=50% reduction in the MADRS total score from baseline [Day 1 pre-randomization] at the end of the 4-week double-blind induction phase)	Exclusion Criteria: - Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode, to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (ie, duloxetine, escitalopram, sertraline, and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ), or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT – Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression - Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis, bipolar or related disorders (confirmed by the MINI), comorbid obsessive compulsive disorder, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder, or narcissistic personality disorder - Participant has homicidal ideation/intent, per the investigator’s clinical judgment, or has suicidal ideation with some intent to act within 6 months prior to the start of the screening/prospective observational phase, per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (CSSRS) - Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-5vkxts	A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment resistant Depression	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	770	An Open-label, Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2015-07-23	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-5vkxts	<NULL>	Research participants with direct Entry: The study population will include men and women with 18 years of age who meet the Manual of diagnostic criteria Diagnostic and Statistical of Mental Disorders (5th edition, DSM-5) for recurrent MDD or MDD single episode ( a single episode, the episode duration should be 2 years) without psychotic features, based on clinical evaluation and confirmed by Mini International Neuropsychiatric Interview (MINI). In screening, the research participant must have a MADRS total score 22, which corresponds to at least moderate depression .Research participants with direct entry will be eligible for screening regardless of whether they are taking or not currently oral antidepressant medications. In screening, the research participants with direct entry must habe no response to two different oral antidepressant treatments administered in proper dosage and proper duration (including oral antidepressant currently taken, if applicable), as measured in MGH-ATRQ and documented by history medical and / or pharmacy records / prescription for the current episode .Research participants  with transfer entry. All survey participants with transfer entry (elderly research participants with 65 years of age) who completed the double-phase induction blind ESKETINTRD3005 study will be eligible for this study: nonresponders research participants will join the study at the beginning of the open induction phase; responders research participants will join the study from the beginning of the optimization/maintenance phase.	Potential research participants will be excluded from participation in the study if they have previously shown no response of depressive symptoms to escetamina or ketamine in the current major depressive episode or all of the oral antidepressant treatment available in their country in the open induction phase (ie, duloxetine, escitalopram, sertraline and venlafaxine XR) in the current major depressive episode (based on MGH-ATRQ). Research participants will also be excluded if they have a DSM-5 diagnostic current or previous a psychotic or MDD disorder with psychosis, bipolar and related disorders (confirmed by MINI), obsessive compulsive disorder comorbid, intellectual disability (DSM-5 diagnostic codes 317 , 318.0, 318.1, 318.2, 315.8 and 319), autistic spectrum disorder, borderline personality disorder, antisocial personality disorder, histrionic personality disorder or narcissistic personality disorder; if they presented ideation / homicidal or suicidal ideation intent with any intention to act within 6 months before the screening phase according to the clinical judgment of the investigator and / or based on Suicide Severity Rating Scale Columbia ( CSSRS); or have a history of disorder or substance use moderate or severe alcohol according to the DSM-5. Furthermore, study participants with 65 ages will be excluded if they have neurodegenerative disorders (eg., Alzheimer&apos;s disease, vascular dementia, Parkinson&apos;s disease) or mild cognitive impairment evidence (MCI) or a score of the Mini Mental State Examination ( MMSE) 25.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-3xk32h	A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants with Treatment-resistant Depression	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	771	A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy,  Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly  Subjects with Treatment-resistant Depression	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-08-24	Clinica Dr. Norton Sayeg Ltda. EPP	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3xk32h	<NULL>	Study population will include older men and women, 65 years of age (inclusive) and above, meeting the Manual of diagnostic criteria Diagnostic and Statistical of Mental Disorders (5th edition, DSM-5) for single episode of MDD (if MDD single episode, the duration shall be 2 years) or MDD recurrent without psychotic features, based on clinical assessment and confirmed by the International Mini Neuropsychiatric Interview (MINI). In addition, the research participant must have a total score of Inventory Symptomatology Depressiva Evaluated by Medical 30 items (IDS-C30) of 34, which corresponds to moderate depression severa.No early screening / prospective observational phase, research participants should be submitted no response to 2, but 5, oral antidepressant treatments administered at an appropriate dose and a suitable duration, as assessed using the response Questionnaire Treatment antidepressant - Massachusetts General Hospital (MGH-ATRQ) and documented by medical history and pharmacy records / prescription for the current episode of depression. At the start of screening / prospective observational phase, the research participant must be one of those currently taking antidepressant treatments with non-major depressive episode documentada.O response current research participant and the treatment response to antidepressant treatments used in the present depressive episode ( assessed retrospectively) should be considered valid for participation in a clinical trial based on a Qualification Assessment Centre Independent. The Qualification Assessment Centre Independent is a tool to facilitate the selection of research participants for clinical studies of MDD, with a goal to ensure the inclusion of research participants that reflect the current state of disease, and that these symptoms can be measured reliably with appropriate measuring tools	Potential research participants will be excluded from participation in the study if they have previously shown no response of depressive symptoms to escetamina or ketamine in the current major depressive episode, all four options oral antidepressant treatment available for the phase double-blind induction (ie, duloxetine, escitalopram, sertraline and venlafaxine XR) a larger current depressive episode (based on MGHATRQ), or an appropriate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT. Research participants who currently have an implant to vagal nerve stimulation (VNS) or who received deep brain stimulation (DBS) in this major depressive episode will be deleted. Survey participants will also be excluded if they have a DSM-5 diagnostic current or previous a psychotic or MDD disorder with psychosis, bipolar and related disorders (confirmed by MINI), obsessive compulsive disorder comorbid, neurodegenerative disorder (eg., Disease Alzheimer&apos;s disease, vascular dementia, Parkinson&apos;s disease) or mild cognitive impairment evidence (MCI), a score of the Mini-Mental State Examination (MMSE) &lt;25, STOP-Bang questionnaire score of 5, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder or narcissistic personality disorder; if they presented ideation / intent homicidal or suicidal ideation with any intention to act within 6 months before the start of the phase of screening / prospective observational according to the clinical judgment of the investigator and / or based on Suicide Severity Rating Scale Columbia (C-SSRS); or have a history of disorder or substance use moderate or severe alcohol according to the DSM-5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-2pk58p	"An Efficacy and Safety Study of Ustekinumab in Participants With Active Nonradiographic Axial
Spondyloarthritis"	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	772	CNTO1275AKS3003 - A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Ustekinumab in the Treatment of Subjects With Active Nonradiographic Axial Spondyloarthritis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-06-30	CPCLIN - CENTRO DE PESQUISAS CLINICAS LTDA	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-2pk58p	<NULL>	Research participants should be between 18 and 50 years of age.Rresearch participants should be classified as having NR AxSpA, based on the ASAS criteria 2009.Must present diagnostic nr-AxSpA, according to the criteria of 2009 ASAS, for 5 years.Must be 45 years old at onset of nr-AxSpA .In selection or within 3 months of selection, research participants are to present active inflammation on MRI highly suggestive of sacroiliitis associated with spondyloarthritis and should not present radiographic sacroiliitis that meets the 1984 (New York criteria modified as confirmed by an X-ray rated by central readers ) .Must present symptoms of active disease at screening and at baseline, as evidenced by both BASDAI score 4 as by a score of VAS 4 of total back pain, each on a scale of 0 to 10.Must present an inadequate response to at least two NSAIDs over a period of 4 weeks, in total, with the maximum doses recommended NSAID (s) or be unable to receive a full period of 4 weeks of treatment with most NSAIDs because of intolerance, toxicity or contraindications for NSAIDs.Research participants previously treated with an anti-TNF biologic agent must be: primary or secondary responders to at most one anti-TNF agent or intolerance present documented maximum one anti-TNF treatment or have discontinued at most 1 anti-TNF agent due to lack of efficacy / safety .IF are using other NSAIDs or analgesics for nr-AxSpA, research participants should be receiving a stable dose for at least 2 weeks prior to first administration of study drug. If are not currently using NSAIDs or other analgesics for nr-AxSpA, research participants must not have received NSAIDs or other analgesics for nr-AxSpA for at least 2 weeks prior to first administration of the drug estudo.If are using corticosteroids oral, research participants should be receiving a stable dose equivalent to 10 mg of prednisone / day for at least 2 weeks prior to first administration of the study drug .If currently are not using corticosteroids, the research participants must not have received oral corticosteroids for at least 2 weeks prior to first administration of the study drug .If are using methotrexate, sulfasalazine or hydroxychloroquine, research participants should have started treatment at least 3 months prior to the first dose of study drug and should not present no serious toxic side effects attributable to these DMARDs.	Present radiographic sacroiliitis that meets the 1984 New York modified criteria. Present other inflammatory diseases that may confound the ratings of the benefit of treatment with ustekinumab, including, among others: rheumatoid arthritis, systemic lupus erythematosus or Lyme. Women that is pregnant, breastfeeding or planning a pregnancy or man that bear a child in a woman during inclusion in the study or within 5 months after receiving the last dose of the study drug .Have received any systemic immunosuppressant or DMARD other than MTX, SSZ or HCQ within 4 weeks before the first administration of the study drug .Have received leflunomide within 3 months before first dose of study medication or receiving leflunomide within 12 months prior to first administration of study drug and not having undergone a drug elimination procedure.Have received corticosteroids epidural, intra-articular, IM or IV, including adrenocorticotropic hormone during 4 weeks prior to the first administration of the study drug .Have ustekinumab or any other agent whose target is IL-23.Have prior received more than one anti-TNF agent .Have received infliximab or biosimilar infliximab within 12 weeks before the first administration of the study drug.Have received adalimumab, golimumab, certolizumab pegol. etanercept within 6 weeks prior to the first administration of the study drug .Have received prior biological treatment other than anti-TNF before the first dose of the study drug .Have ever received tofacitinibe or any other inhibitor of Janus quinases.Present any known hypersensitivity to human protein immunoglobulin .Have used citotoxics drugs .Present a history of active granulomatous disease before selection.Have received vaccination with Bacillus Calmette-Guérin within the 12 months prior to selection .Present a chest radiograph within the previous 3 months the first dose of study drug to show a suggestive abnormality of malignancy or current active infection, including  TB. Have presented a mycobacterial nontuberculous infection or oportunist infection.Have received, or is expected to receive any vaccination with alive virus or alive bacteria in the 3 months prior to the first administration of study medication during the study or within 3 months after the last administration of the study drug .Present one history of joint prosthesis infected or have received antibiotics for a suspected prosthetic joint infection. have presented a serious infection or have been hospitalized because of an infection or have been treated with IV antibiotics for an infection within the two months prior to the first administration of study drug. Presenting a history of infectious disease or current infectious disease, chronic or recurrent. Research participant present a history of positivity for antibodies to HIV or tested positive for HIV in selection. Present infection for Hepatitis B.Research Participantes who are positive for antibodies to hepatitis C.Present signs or current symptoms of kidney disease, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, cardiac, neurological, brain or severe psychiatric, progressive or not controled. Present a known history of lymphoproliferative disease. The research participant presents a history of malignancy within 5 years prior to selection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-9jqhyc	Study to Evaluate Imetelstat (JNJ- 63935937) in Subjects with International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)	Recruiting	Intervention	2016-03-30	<NULL>	<NULL>	774	A Study to Evaluate Imetelstat (JNJ- 63935937) in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) that is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-02-01	Fundação Pio XII - Hospital de Câncer de Barretos	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9jqhyc	<NULL>	Inclusion Criteria: Man woman greater than or equal to (&gt;=) 18 years of age; Diagnosis of myelodysplastic syndrome (MDS) according to World Health Organization (WHO) criteria or French- American-British (FAB) classification confirmed by bone marrow aspirate and biopsy within 12 weeks prior to Study Entry. A local laboratory report from this diagnostic bone marrow aspirate and biopsy must be reviewed and approved by the sponsor; International Prognostic Scoring System (IPSS) low Risk or intermediate-1 risk MDS; Red blood cell (RBC) transfusion dependent, defined as requiring 4 units RBC over 8 weeks during the 12 weeks prior to Study Entry; pretransfusion hemoglobin (Hb) should be less than equal to 9.0 gram per deciliter (g/dL) to count towards the 4 units total; Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2	Exclusion Criteria: Participant has known allergies, hypersensitivity, or intolerance to imetelstat or its excipients; Participant has received an investigational drug or used an invasive investigational medical device within 30 days prior to Study Entry or is currently enrolled in an investigational study; Prior treatment with imetelstat; Have received any chemotherapy, immunomodulatory or immunosuppressive therapy, corticosteroids greater than 30 milligram per day prednisone or equivalent, or growth factor treatment within 28 days prior to study entry; Have received other treatments for MDS within 4 weeks prior to Study Entry	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-9pgk4f	A study of Intranasal Rapid Action Esketamine for Major Depression Treatment Resistant	Recruiting	Intervention	2016-04-01	<NULL>	<NULL>	778	A study of Intranasal Rapid Action Esketamine for Major Depressive Disorder Treatment Resistant	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-08-10	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-9pgk4f	<NULL>	At the time of signing the informed consent form (ICF), participant must be a man or woman 18 (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age, inclusive - At the start of the screening/prospective observational phase, participant must meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD, the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD, without psychotic features, based upon clinical assessment and confirmed by the Mini- International Neuropsychiatric Interview (MINI) - At the start of the screening/prospective observational phase, participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34 - At the start of the screening/prospective observational phase, participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration, as assessed using the Massachusetts General Hospital - Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records, for the current episode of depression: Subject must be taking an oral antidepressant treatment with nonresponse at the start of the screening/prospective observational phase - The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment	Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode, to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (ie, duloxetine, escitalopram, sertraline, and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ), or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode, defined as at least 7 treatments with unilateral ECT - Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression - Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis, bipolar or related disorders (confirmed by the MINI), comorbid obsessive compulsive disorder, intellectual disability (only DSM-5 diagnostic code 319), borderline personality disorder, antisocial personality disorder, histrionic personality disorder, or narcissistic personality disorder - Participant has homicidal ideation/intent, per the investigator’s clinical judgment, or has suicidal ideation with some intent to act within 6 months prior to the start of the screening/prospective observational phase, per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (C-SSRS) – Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:15
RBR-386vfr	Stimulation of reaching behavior using sticky mittens in preterm infants	Recruiting	Intervention	2016-04-04	<NULL>	<NULL>	782	Practice of reaching using sticky mittens in preterm infants: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-15	Universidade Federal de Mato Grosso do Sul (UFMS)	Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (Fundect)	https://ensaiosclinicos.gov.br/rg/RBR-386vfr	<NULL>	Infants born with less than 37 weeks of gestational age; with first and fifth minute Apgar Scores greater than 7;  without major pre- and perinatal complications; at maternal care.	High-risk infants; with clinical signs/diagnosis of neurological impairment, congenital malformations, genetic syndromes, visual and auditory alterations, cardiorespiratory difficulties or musculoskeletal impairment; who do not collaborate during pre-training and post-training measures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-7gy99f	Relationship of female sexuality with physical activity, depression, quality of life and muscle force	Recruiting	Observational	2016-04-04	<NULL>	<NULL>	783	Female sexual function: relationship with physical activity, depression, quality of life and functionality of the pelvic floor and abdominal muscles	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7gy99f	<NULL>	Undergraduate; students of Biological Sciences Sector courses of the Federal University of Parana; female; over the age of eighteen; who have active sex life; that has not pregnant; without distinction of race; without distinction of sexual orientation; without distinction of class social.	Women in pregnancy; sexual abstinence in the past six months; suffering from neuromuscular diseases; which do not show integrity to the pelvic floor sensitivity test or had a surgical procedure in abdominal/pelvic or musculoskeletal surgery region in the lower limbs at least six months; women who are making use of psychiatric drugs for example antidepressants and anxiolytics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-247s9q	Study of Intranasal Rapid Action Esketamine for treatment of Major Depressive Disorder Treatment Resistant	Recruiting	Intervention	2016-04-04	<NULL>	<NULL>	784	"A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed
Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Subjects with Treatment-resistant Depression - ESKETINTRD3001"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-06-29	Centro De Psiquiatria E Pesquisas Sandra Ruschel Ltda	Janssen-Cilag Farmacêutica Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-247s9q	<NULL>	man or woman 18 years old (or older if the minimum legal age of consent in the country in which the study is taking place is greater than [&gt;]18) to 64 years of age; meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria for single-episode major depressive disorder (MDD) (if single-episode MDD the duration must be greater than or equal to [&gt;=] 2 years) or recurrent MDD without psychotic features based upon clinical assessment and confirmed by the Mini-International Neuropsychiatric Interview (MINI); At the start of the screening/prospective observational phase; participants must have had nonresponse to &gt;=2 but less than or equal to (&lt;=) 5 oral antidepressant treatments taken at adequate dosage and for adequate duration as assessed using the Massachusetts General Hospital Antidepressant Treatment Response Questionnaire (MGH-ATRQ) and documented by medical history and pharmacy/prescription records for the current episode of depression. Participant must be taking an oral antidepressant treatment with nonresponse at the start of the screening/prospective observational phase; At the start of the screening/prospective observational phase participant must have an Inventory of Depressive Symptomatology-Clinician rated ( IDS-C30) total score of greater than or equal to (&gt;=) 34; The participant’s current major depressive episode and treatment response to antidepressant treatments used in the current depressive episode (retrospectively assessed) must be deemed valid for participation in a clinical study based on a Site-Independent Qualification Assessment	Participants who have previously demonstrated nonresponse of depressive symptoms to esketamine or ketamine in the current major depressive episode. to all 4 of the oral antidepressant treatment options available for the double-blind induction phase (i.e. duloxetine. escitalopram. sertraline. and venlafaxine extended release [XR]) in the current major depressive episode (based on MGH-ATRQ) or an adequate course of treatment with electroconvulsive therapy (ECT) in the current major depressive episode defined as at least 7 treatments with unilateral ECT; Participant currently has an implant for vagal nerve stimulation (VNS) or has received deep brain stimulation (DBS) in the current episode of depression; Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis. bipolar or related disorders (confirmed by the MINI). comorbid obsessive compulsive disorder. intellectual disability (only DSM-5 diagnostic code 319). borderline personality disorder. antisocial personality disorder. histrionic personality disorder. or narcissistic personality disorder; Participant has homicidal ideation/intent per the investigator’s clinical judgment or has suicidal ideation with some intent to act within 6 months prior to the start of the screening prospective observational phase per the investigator’s clinical judgment or based on the Columbia Suicide Severity Rating Scale (C-SSRS); Participants with history of moderate or severe substance or alcohol use disorder according to DSM-5 criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-8q3p8n	Pilates and Global Postural Reeducation to school children.	Recruiting	Intervention	2016-04-05	<NULL>	<NULL>	786	Comparative study of Mat Pilates and Global Postural Reeducation protocol on postural alignment and functional capacity of school children.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-20	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8q3p8n	<NULL>	Children with good cognition; with aged 4-8 years.	Children with previous orthopedic surgery; cardiac, respiratory or psychological conditions that compromise the implementation of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-25372s	Clinical Effects of Diet on Dental Bleaching	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	789	Clinical Effects of Diet Change Directive During In-office Bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-29	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-25372s	<NULL>	For the presente study, it will be selected 60 patients with the following inclusion criteria: Above 18 years-of-age; Front teeth free of caries and periodontal disease; At least one upper central incisor of A2 or darker color.	Patients who have already undergone whitening treatment; Patients with prosthesis or restorations on the labial surface of the front upper teeth; Patients with severe internal alterations of color (fluorosis and stains by tetracycline); Pregnant or lactating women; Smokers; Patients using fixed orthodontic appliances;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-836wwd	Effect of prior application of 10% potassium nitrate in reducing tooth sensitivity resulting from in-office dental bleaching: a randomized clinical trial, triple blind, placebo-controlled, split-mouth	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	790	Preoperative application effect of 10% potassium nitrate reduction in tooth sensitivity resulting from in-office dental bleaching: a randomized clinical trial, triple blind, placebo-controlled, split-mouth	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-26	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa - UEPG	https://ensaiosclinicos.gov.br/rg/RBR-836wwd	<NULL>	Patients older than 18 years are included; with good oral and general health; with the maxillary anterior teeth free restorations and presenting no carious lesion; which possess the color of teeth A2 or darker depending on the color scale Vita Classical (Vita Zahnfabrik, Bad Säckingen, Germany) and to agree with the free and informed consent form.	Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; who report tooth sensitivity; severe browning (staining by tetracycline, fluorosis or endodontics); with deleterious habits; people with dental prostheses and orthodontic appliances and any other oral pathology . Although patients will be excluded that present systemic changes such as stomach, heart, kidney and liver problems, diabetes, hypertension or are making continual use of drugs with analgesic and anti-inflammatory.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-3h33wy	Ciprofloxacin effectiveness of the assessment to prevent bacterial infection of patients victims of accidents with snake in the Brazilian Amazon	Recruiting	Intervention	2016-04-08	<NULL>	<NULL>	791	Early empirical antibiotic therapy: a randomized clinical trial for superiority of a ciprofloxacin versus placebo in for preventing secondary bacterial infection among snakebite victims in the Brazilian Amazon	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-07-10	Universidade do Estado do Amazonas	Fundação de Amparo à Pesquisa do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3h33wy	<NULL>	To have less than 24 hours of the accident; did not to use any antibiotics before answering the institution; to have not done the antivenom for the current snakebite ; to have no abscess or infection clearly established at the time of admission ; not to be allergic to the antibiotic of choice in this study ; not to be pregnant and not accept participate.	have mental inability to understand the objectives of the study and participate in the survey; have acute or chronic unstable; unavailability of stay in hospital for seven days to follow.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-9b969b	"An Electronic Program to help people to take
decision to quit smoking"	Recruiting	Intervention	2016-04-10	<NULL>	<NULL>	792	An Electronic Program to help people make the decision to quit smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-04	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	https://ensaiosclinicos.gov.br/rg/RBR-9b969b	<NULL>	Smokers assets; age above 18 years; of both sexes; in the treatment at the Centro Hiperdia Minas -Juiz de Fora and e Serviço de controle de Hipertensão; Diabetes e Obesidade da Prefeitura Municipal de Juiz de Fora who signed the free and informed consent.	Active smokers under 18	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-49mqhs	Evaluation of partial  caries removal in primary and permanent molars over time	Recruiting	Intervention	2016-04-10	<NULL>	<NULL>	795	"Partial caries removal in primary and permanent molars:
Longitudinal clinical trial"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-26	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-49mqhs	<NULL>	Eighty Children aged 8 to 15 years; both genders; carrying at least one deep active occlusal caries lesion (inner half dentin diagnosed radiographically) in previously unrestored primary and permanent molar and complying the score 3 index Nyvad without pulpal involvement (cavity in enamel and dentin; visible to the naked eye; cavity surface softened or leathery to soft probe).	Children who have debilitating systemic diseases that might interfere with some of caries risk factors; children with salivary changes (xerostomy) and / or are making use of medicines in the last 3 months like the use of antibiotics. Teeth with clinical signs or symptoms and radiographic findings that may assume irreversible pulp inflammation or pulp necrosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-3j6xjy	Effects of medical telephone discussion on the endocrinology referral list	Recruiting	Intervention	2016-04-12	<NULL>	<NULL>	797	Evaluation of the effectivity of teleconsultations for improving the quality of the referrals from primary care to specialized care of patients nonresidents in Porto Alegre with endocrine health conditions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-02	Programa de Pesquisa e Pós-Graduação em Epidemiologia / Universidade Federal do Rio Grande do Sul	Secretaria Estadual da Saúde do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3j6xjy	<NULL>	Referrals from patients from counties with at least 5 endocrinology referrals waiting appointment for endocrinology specialty. Referrals from adult patients (more than 18 years old). Referrals from the primary care. Referrals which the reason for referral is included in one of the referring protocols (Diabetes Mellitus; Hypothyroidism; Hyperthyroidism; Goiter; Thyroid nodule; Obesity).	Referrals from patients from counties with more than one hundred endocrinology referrals waiting appointment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:16
RBR-2x86dc	"Observational study to assess data from the past related to the rate of hospitalization in
Patients with Schizophrenia treated one year before with oral drugs for Schizophrenia and
one year after with injectable drugs for Schizophrenia"	Recruiting	Observational	2016-04-15	<NULL>	<NULL>	802	"A retrospective, observational study to assess the rate of hospitalization in
patients with Schizophrenia treated one year before with oral Antipsychotics and
one year after with long acting injectable Atypical Atipsychotics"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-04	Universidade Federal de São Paulo - UNIFESP/EPM	Janssen-Cilag Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2x86dc	<NULL>	"Out-Patients with the main diagnosis of schizophrenia; only clinical records with complete information during the 2 years period
selected for data analysis will be included; patients treated with oral antipsychotics then switched to long acting injectable atypical due to poor adherence, lack of efficacy (no significant symptom reduction, judged by physician, at maximum recommended dose of an antipsychotic for 6 weeks), patients’ choice, when the switch has not been clearly justified or the switch has not been done during hospitalization; being regularly treated with long acting injectable atypical antipsychotics for at least 1 year after the initial use of long acting injectable atypical antipsychotics."	Patients that started long acting injectable atypical antipsychotics treatment as in-patients and patients that switched to long acting injectable atypical antipsychotics during hospitalization; patients with schizophrenia resistant to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-5pc43m	Auriculotherapy to reduce pain, anxiety and improving the quality of life	Recruiting	Intervention	2016-04-19	<NULL>	<NULL>	804	Effectiveness of auriculotherapy to reduce pain and anxiety and improving the quality of life of nursing professionals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-26	Escola de Enfermagem da Universidade de São Paulo	Leonice Fumiko Sato Kurebayashi	https://ensaiosclinicos.gov.br/rg/RBR-5pc43m	<NULL>	The subjects of the nursing staff (auxiliaries, technicians and nurses) that present a score above 33 points according to the State-Trait Anxiety Inventory (middle and high level of anxiety) and those who have availability of time for submission to the sessions.	Pregnant women; subjects who go on vacation or sick leave during the research period; those who begin to use allopathic medicines for anxiety and antidepressants during the period of research; those who have metal and adesive tape allergy and who initiate other complementary therapies (acupuncture, massage, herbal medicine, Reiki, Flower therapy etc.) for anxiety control during the period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-3f8rzs	Effects of low level laser therapy in the electromyographic fatigue of bíceps brachi muscle before and after a resistive program training in young males	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	805	Effects of low level laser therapy in the electromyographic fatigue, in the blood lactate, and in the inflamatory markers after induced biceps  biceps brachi muscle fatigue before and after a resisitive  program training in young males	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3f8rzs	<NULL>	"Full active range of motion and no pain in the shoulder, elbow and wrist; 
Absence of fracture or previous surgery on spine and upper extremities; 
Considered insufficiently active for IPAQ; 
Not be in training for at least six months."	"Restriction in range of motion of shoulder, elbow and wrist; 
History of trauma or previous surgery in trunk; upper extremities; 
History biceps muscle injury; 
Subluxation of the glenohumeral joint; 
Rheumatic, neurological or degenerative disease;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-6zc4cb	Comparitive study between Carnoy and GEWF solutions for identifying lymph nodes in patients with cancer of the large bowel	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	806	Randomized clinical trial comparing Carnoy&apos;s and GEWF solutions for Lymph Node Clearing Technique in Colorectal Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Hospital Moinhos de Vento	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6zc4cb	<NULL>	Patients with histologically proven adenocarcinoma of the colon or rectum; both sexes; over 18 years of age; underwent surgical treatment performed by colorectal surgeons; agreement of the attending physician and the patient to participate in the study ;	Inaccuracy or unavailability of patient´s data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-9nq7qd	Study to evaluate and compare anti retroviral tablet formulations for oral fixed dose and solutions in children	Recruiting	Intervention	2016-04-25	<NULL>	<NULL>	810	Open, randomized study to evaluate the safety and pharmacokinetic parameters comparing antiretroviral formulations fixed-dose tablet and oral solution in pediatric population	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2015-10-28	Universidade Federal de Minas Gerais	Instituto de Tecnologia em Fármacos - Farmanguinhos	https://ensaiosclinicos.gov.br/rg/RBR-9nq7qd	<NULL>	"Weight between 6.5 and 24.9kg;Confirmed HIV infection; documented by positive results from two samples collected at different times prior to entering the study:Sample # 1 can be tested using:Two rapid tests from two different manufacturers antibodies or based on principles and different antigenic determinants (for larger participants 18 months);An essay EIA OR Western blot OR immunofluorescence assay OR chemiluminescence assay (for larger participants 18 months);A PCR HIV DNA;A quantitative PCR HIV DNA (&gt; 5,000 copies / mL);A qualitative PCR HIV DNA;
A complete test detection of nucleic acids for the HIV virus;2. Sample # 2 can be tested using:An EIA confirmed OR Western blot OR immunofluorescence assay OR chemiluminescence assay (for larger participants 18 months);
A PCR HIV DNA;A quantitative PCR HIV DNA (&gt; 5,000 copies / mL);A qualitative PCR HIV DNA;
A complete test detection of nucleic acids for the HIV virus;In use of highly active antiretroviral therapy (HAART); with stable laboratory tests (viral load and CD4 +) or treatment-naïve;Demonstrate availability and willingness to ingest the drugs studied;
5. Willingness to stay in the hospital for 12 hours for pharmacokinetic study;Parents or legal guardians must be able; agree and are willing to sign the Instrument of Consent;
Female participants; after menarche; must agree to use two forms of contraception from the menarche;Note: female participants with reproductive potential (after menarche) with sexual activity that can result in pregnancy; they must agree to avoid pregnancy in a consistent and appropriate manner with at least two of the following contraceptive methods: condoms; diaphragm or cervical cap with spermicide; IUD; hormonal contraceptives."	Values outside normal laboratory tests in step 4; according to the DAIDS toxicity table (Annex IV); up to 2 weeks before study entry;Vomiting and diarrhea (greater than grade 2) at least 30 days prior to study entry;Treatment of bacterial; viral or acute severe opportunistic;History of drug toxicity requiring discontinuation of any study drug;Hypersensitivity to drugs under study;medical or surgical problems affecting motility or gastrointestinal absorption (eg: ileus; ulcerative colitis) or liver function;Treatment with experimental drugs within 30 days prior to study entry;Any acute hepatitis;Chemotherapy for cancer;Any disease or clinically significant findings during the medical assessment or physical examination that; in the opinion of the investigator; may interfere with the study;Pregnancy;Failure immune defined as:Incomplete immune response: defined as a failure in subjects with severe immunodeficiency (baseline CD4 percentage &lt;15%) to achieve at least five percentage points increment or children 5 years of age; to increase the absolute value of CD4 . at least 50 cells / mm3 during the first year of treatment;Immune Worsening: defined as the sustained drop of five points in the percentage of CD4 at any age; or fall to values below the absolute number of pretreatment CD4 in children 5 years of age (Brazil; 2009).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-28z7r7	The electrical stimulation&apos;s influence of medium and low frequency on the functional performance of soccer players	Recruiting	Intervention	2016-04-27	<NULL>	<NULL>	815	The influence of medium and low frequency currents on the functional performance of soccer players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-28z7r7	<NULL>	"Male (n=30).
Age between 18-30 years.
Being college player of field football.
To be at least three months without practice strength training."	"Presenting some kind of dysfunction in skeletal muscle that may interfere.
Presenting intolerance in neuromuscular electrical stimulation.
Injury history or surgeries in lower limb que affect the application of electrical stimulation.
Continuous use of analgesics; tranquilizers; antidepressants or other central agent.
Vascular or cardiovascular problems; chronic diseases; muscle or neurological disorders that can not permit a complete executions of activities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-9s8t88	Cardiovascular effects of the perineal muscles contractions in pregnant women	Recruiting	Intervention	2016-04-27	<NULL>	<NULL>	817	Cardiovascular responses to pelvic floor muscle contractions in pregnant women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9s8t88	<NULL>	18 weeks of pregnancy;age group of 18 to 40; body mass index (BMI) for gestational age according to Atalah Table (Atalah SE et al, 1997).; first or second pregnancy.	High-risk pregnancy; drugs use; prolapse of pelvic organs; history of pelvic surgery; taking drugs that influence BP and HR (beta blockers; calcium channel inhibitors; anti anxiety drugs); vaginal palpation Intolerance (examination);inability to perform muscle contraction (P &lt;2 according to PERFECT method Laycock&amp; Jerwood (2001)); changes in the cardiovascular and respiratory systems; cardiovascular and diabetes diseases diagnosed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-82bcmz	Effects of low level laser therapy in muscle fatigue of elderly women pre and post a quadríceps femoris exercise program	Recruiting	Intervention	2016-04-28	<NULL>	<NULL>	819	Effects of low level laser therapy in peripherical muscle fatigue in elderly women submitted to a program of muscular strength	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-31	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-82bcmz	<NULL>	"No pain or dysfunction in trunk and lower extremities 
Full active range of motion of hip, knee and ankle
Absence of fracture or previous surgery in the spine and lower extremities
Considered insufficiently active for IPAQ"	"Pain in the lower extremities or trunk; 
Restriction in range of motion of hip, knee and ankle; 
History of trauma or previous surgery in  lower extremities or spine; 
History of quadriceps femoris muscle injury; 
Subluxation of  hip joint; 
Osteoarthritis in  hip and knee; 
Rheumatic e, degenerative or neurological diseas; 
Diabetes mellitus and fibromyalgia; 
Subjects with uncontrolled hypertension."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:17
RBR-4f9tcc	Efficacy and safety study of Fluticasone Furoate/Vilanterol on the dose of 100/25 microgram (mcg) inhalation powder, Fluticasone Propionate/Salmeterol on the dose of 250/50 mcg inhalation powder and Fluticasone Propionate on the dose of 250 mcg inhalation powder in adults and adolescents with persistent asthma	Recruiting	Intervention	2016-04-29	<NULL>	<NULL>	825	A randomized, double blind, double dummy, parallel group, multicenter study of once daily Fluticasone Furoate/Vilanterol 100/25 mcg inhalation powder, twice daily Fluticasone Propionate/Salmeterol 250/50 mcg inhalation powder, and twice daily Fluticasone Propionate 250 mcg inhalation powder in the treatment of Persistent Asthma in adults and adolescents already adequately controlled on twice daily inhaled Corticosteroid and long acting beta2 Agonist	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-03-09	GlaxoSmithKline Brasil	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4f9tcc	<NULL>	"Subjects must give their signed and dated written informed consent to participate prior to start any study activities;
Subjects must be outpatients equal or more than 12 years of age at visit 1 and diagnosed with asthma, as defined by the National Institutes of Health, for at least 12 weeks prior to visit 1;
Male and female (if eligible). An eligible female is defined as having non-childbearing potential or having childbearing potential and a negative urine pregnancy test at screening and agrees to use an acceptable method of birth control consistently and correctly;
Subjects must have a FEV of equal or more than 80% of the predicted normal value;
If they have received mid dose of inhaled corticosteroids(ICS) plus Beta-2 agonist prolonged action (LABA), equivalent to Fluticasone Propionate/Salmeterol 250/50 micrograms(mcg) twice daily or an equivalent combination via separate inhalers for at least the 12 weeks immediately preceding visit 1;
Subjects must be able to replace their current SABA treatment with albuterol/salbutamol aerosol inhaler at visit 1 for use, as needed, for the duration of the study. Subjects must be able to with hold albuterol/salbutamol for at least 6 hours prior to study visits;
If in the opinion of the investigator the subject&apos;s asthma is well controlled"	"History of life-threatening asthma, defined for this protocol as an asthma episode that required intubation and/or associated with hypercapnea, respiratory arrest or hypoxic seizures within the last 5 years;
Culture-documented or suspected bacterial or viral infection of the upper or lower respiratory tract, sinus or middle ear that is not resolved within 4 weeks of visit 1 and led to a change in asthma management or in the opinion of the investigator, expected to affect the subject&apos;s asthma status or the subject&apos;s ability to participate in the study;
Any asthma exacerbation requiring oral corticosteroids within 12 weeks of visit 1 or resulting in an overnight hospitalization requiring additional treatment for asthma within 6 months prior to visit 1;
A subject must not have current evidence of atlectasis, bronchopulmonary dysplasia, chronic bronchitis, chronic obstructive pulmonary disease, pneumonia, pneumothorax, interstitial lung disease, or any evidence of concurrent respiratory disease other than asthma;
A subject must not have any clinically significant, uncontrolled condition or disease state that, in the opinion of the investigator, would put the safety of the subject at risk through study participation or would confound the interpretation of the results if the condition/disease exacerbated during the study;
A subject must not have used any investigational drug within 30 days prior to Visit 1 or within five half-lives (t½) of the prior investigational study, whichever is longer of the two;
Any adverse reaction including immediate or delayed hypersensitivity to any beta2-agonist, sympathomimetic drug, or any intranasal, inhaled, or systemic corticosteroid therapy. Known or suspected sensitivity to the constituents of the study molecules;
History of severe milk protein allergy;
Administration of prescription or non-prescription medication that would significantly affect the course of asthma, or interact with study drug;
A subject must not be using or require the use of immunosuppressive medications during the study;
A subject will not be eligible if he/she or his/her parent or legal guardian has any infirmity, disability, disease, or geographical location which seems likely (in the opinion of the Investigator) to impair compliance with any aspect of this study protocol, including visit schedule and completion of the daily diaries;
Current tobacco smoker or has a smoking history of 10 pack-years (20 cigarettes/day for 10 years). A subject may not have used inhaled tobacco products or inhaled marijuana within the past 3 months (e.g., cigarettes, cigars, electronic cigarettes, or pipe tobacco);
A subject will not be eligible for this study if he/she is an immediate family member of the participating investigator, sub-investigator, study coordinator, or employee of the participating investigator"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-4vwqck	Identification of risk of accidents in healthy elderly and with Parkinson&apos;s Disease during street crossing simulation: A study based on gait characteristics	Recruiting	Observational	2016-05-03	<NULL>	<NULL>	827	Identification of risk of accidents in healthy elderly and with Parkinson&apos;s Disease during street crossing simulation: A study based on kinematic parameters	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-12-08	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-4vwqck	<NULL>	No pain, fracture, or serious injury to soft tissues in the 6 months previous to the study; no history of cognitive, respiratory or cardiovascular disorders not controlled; elderly with Parkinson&apos;s disease be classified in stages I to III of Hoehn Yahr scale; elderly with Parkinson&apos;s disease not be in pharmacological adaptation phase.	Individuals who present uncontrolled cardiovascular changes; to present score lower than 24 on the Mini Mental State Examination that will be applied before the collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-9rpqdn	Use of medication for preventing diabetes in obese pregnant women	Recruiting	Intervention	2016-05-04	<NULL>	<NULL>	830	Use of metformin for the prevention of gestational diabetes mellitus in obese pregnant women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-10-31	Universidade da Região de Joinville Univille	Universidade da Região de Joinville Univille	https://ensaiosclinicos.gov.br/rg/RBR-9rpqdn	<NULL>	With obesity diagnosis of pregnant women will be selected according to the criteria of the World Health Organization with BMI or greater than 30 kg / m2; aged over 18 years; singleton pregnancy; with screening for gestational diabetes mellitus (GDM) at the beginning of the negative pregnancy; gestational age less than 20 weeks; no pathology that interferes with glucose metabolism; no hypersensitivity to metformin hydrochloride or important drug allergy; history or presence of liver disease; renal or gastrointestinal or other conditions that interfere with the absorption, distribution, excretion or metabolism of the drug.	Losses following are deleted; intolerance drugs; desire of the pregnant woman; presence of risk to the fetus; allergy to metformin, mother&apos;s death and fetus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-9ztf3b	The use of intranasal ketamine before puncturing a vein in children	Recruiting	Intervention	2016-05-05	<NULL>	<NULL>	832	Ketamine intranasal used as sedative for punch venosa in pediatric patients	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2015-11-16	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9ztf3b	<NULL>	Children hospitalized in the Pediatric Inpatient Units, with the presence of legal guardian; aged 3 months to 12 years; requiring venipuncture independent research.	Severe neurological sequelae; Patients who need immediate venipuncture at risk; Presence of active nosebleeds; Patients using antipsicotrópicos; Children who have experienced clinical change with ketamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-3ysnwj	Clinical trial on the effects of a Hydrotherapy protocol Neonatal Intermediate Care Unit	Recruiting	Intervention	2016-05-05	<NULL>	<NULL>	834	Clinical trial on the effects of a Hydrotherapy protocol Neonatal Intermediate Care Unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Fundação de Amparo à Pesquisa do Estado de São Paulo	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3ysnwj	<NULL>	preterm infants with gestational age less than or equal to 32 weeks ; Hospitalized Neonatal Intermediate Care Unit; in spontaneous breathing ; without central or peripheral venous access ; babies without congenital malformations or chromosomal syndromes or infections in treatment ( change of blood count and blood culture positive ) or neurological disorders ( intracranial hemorrhage grade III or IV, and brain malformations ) ; without skin lesions or other contraindications to body immersion in hot water	adverse reactions to the study protocol (cyanosis , crying or lethargy, facies pain , generalized hyperemia , among others); Epidermal changes ; worsening of symptoms ; intolerance to food or behavioral disorders; events that prevent the study protocol ( need for ventilatory support or intravenous and surgical procedures ) ; parents and / or guardians who request to withdrawn from the infant study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-3bfyzc	Management of Split-thickness skin graft donor sites: a clinical trial with three diferent dressings	Recruiting	Intervention	2016-05-05	<NULL>	<NULL>	836	Management of Split-thickness skin graft donor sites: a randomized clinical trial comparative with three diferent dressings	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2015-10-13	Centro Universitário Cesmac	Aldenir Feitosa dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-3bfyzc	<NULL>	Pacients submitted to Split-thickness akin graft surgery; age between 18 and 60 years; both sexes; donor site dimension around 10x20cm	Volunteers that carriers Diabetes; liver failure; Chronicle obstructive pulmonar disease and chronicle renal insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-352v3g	The simulated nursing education and the clinical competency development	Recruiting	Intervention	2016-05-09	<NULL>	<NULL>	840	The simulated nursing education and the clinical competency development	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Departamento de Enfermagem daUniversidade Federal do Paraná	Departamento de Enfermagem daUniversidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-352v3g	<NULL>	To be a undergraduation nursing student; registered on fourth period of the course during  2015 and 2016.	To have a previous course on healh sciences; or competence as a medical personal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-3vn24z	Releasing adhesive use on premature with  transparent dressingfor fixing central catheter: randomazed clinical trail	Recruiting	Intervention	2016-05-09	<NULL>	<NULL>	841	Releasing adhesive use on premature with semipermeable transparent film por PICC (Peripheral Inserted Central catheter) fixation: randomazed clinical trail	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-14	Universidade Federal do Paraná	Barbara Franco Mittag	https://ensaiosclinicos.gov.br/rg/RBR-3vn24z	<NULL>	"Premature infants less than 36 weeks gestational age at birth;
RNs in use of semipermeable film transparent for fixing of peripheraly inserted central cateter (PICC) inserted in the first two weeks of life;
The consent form signed by those responsible."	"Presence of the skin lesion near of the catheter, prior to insertion;
Fixing the peripheraly inserted central cateter (PICC) with different material than transparent semipermeable film;
Withdrawal of informed consent by those responsible;
Parents under the age of 18 years."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:18
RBR-287q65	Impact of exercise on the urinary control muscles in women with Multiple Sclerosis	Recruiting	Intervention	2016-05-16	<NULL>	<NULL>	846	Impact of pelvic floor training in the treatment of symptoms of lower urinary tract in women with multiple sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-287q65	<NULL>	Women diagnosed with Multiple Sclerosis;  age over 20 years; score on the Expanded Disability Status Scale (EDSS) lower or equal to 6.5; presence of symptoms of urinary dysfunction for at least six months.	Refusal to participate; exacerbation of symptoms  of Multiple Sclerosis during treatment; cognitive decline;  imposibility to attend the treatment sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-4hsfyg	Comparison of effect of bath performed before hip prosthesis surgery with three different solutions	Recruiting	Intervention	2016-05-17	<NULL>	<NULL>	851	Comparison of preoperative bathing effectiveness with three solutions in patients undergoing hip arthroplasty: a clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-18	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-4hsfyg	<NULL>	Patient with an elective procedure of total hip arthroplasty; age of 18 years or more; no report of infection at the surgical site; with access to landline or mobile; know autodiagnosticar informing the clinical signs of the infection or have a responsible with this ability; don&apos;t be Staphylococcus aureus nasal carrier prior to surgery.	Patient treatment of surgical site infection; undergoing hip replacement surgery in urgency situations; emergency; orthopedic trauma; with a history of allergic reactions to the products used in the bath; underwent partial hip arthroplasty surgery; nasal Staphylococcus aureus carriers before surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-49pk78	Comparison of Cicatrization Using Topic Light Emitted Diode in Patients Underwent to Abdominoplasty	Recruiting	Intervention	2016-05-17	<NULL>	<NULL>	852	Comparison Between the Application and No Application of Led (light emitted diode) in Cicatrization of Patient Underwent to Abdominoplasty	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-03-25	Pontifícia Universidade Católica do Rio Grande do Sul	INSERM U1051 Institut des Neurosciences de Montpellier	https://ensaiosclinicos.gov.br/rg/RBR-49pk78	<NULL>	Patients with informed consent signed; caucasian; patients underwent abdominoplasty; patients in whose immediate postoperative period does not show signs of distress or mechanical trauma of the sutured tissue; BMI between 20-30 kg/m2	Patient with indication of multifunctional abdominoplasty or previously undergone to bariatric surgery; patients previously undergoing abdominal surgery that could compromise the vitality of the abdominal flap (cholecystectomy laparotomy for weapon or firearm trauma); patients with autoimmune disorders of collagen metabolism; smoking; diabetes mellitus; chronic hypertension; alcoholism; bleeding disorder; protein malnutrition; immunodeficiency; patients suffering acute or chronic dermatitis or using pharmacological treatment with corticosteroids or chemotherapy; patients undergoing radiation therapy for any reason in the abdominal-pelvic region; patients with known healing disorders (hypertrophic scars or keloids); patients with intestinal bad absorption; patients who have been conducting strict diet prior to surgery; patients who are using another type of product or drug for preventing or improving healing; patient presenting tattoo in the abdominal region and difficult the postoperative evaluation of the scar; patients with medical conditions that interfere with normal wound healing (vitamin C deficiency; iron deficiency; anemia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-8fgft5	Clinical evaluation of ceramic veneers manufactured by computed technology	Recruiting	Intervention	2016-05-22	<NULL>	<NULL>	858	Clinical evaluation of lithium disilicate veneers manufactured by cad/cam technology	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-30	Universidade de São Paulo, Faculdade de Odontologia de Bauru	Fundação de Amparo à Pesquisa do estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-8fgft5	<NULL>	"Patients over 18 years;
Accordance with the TCLE;
Patients who have an indication for veneers: discoloration, tooth wear, fracture or anterior teeth with malformation;
Patients who have good general health during clinical evaluation period, good value mandibular and maxillary occlusal stability;
Patients who have need of treatment by at least two teeth and at most six teeth(region between canines)."	"History of allergy to any of the materials to be used in research
Drugs that could interfere with the oral environment;
Systemic or malignant diseases at the beginning of the study;
Inability to be subjected to specific techniques for performing the experiment not enough space for proper preparation of veneers;
Patients with parafunctional habits;
Patients with periodontitis severe gum inflammation;
Inadequate oral hygiene or high caries rates."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-5t6j5p	Analysis of the effects of vocal training through breath exercises with sound in tube and straw in choir singers	Recruiting	Intervention	2016-05-27	<NULL>	<NULL>	863	Analysis of the effects of vocal conditioning through semi-occluded vocal tract exercises in choir singers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-21	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5t6j5p	<NULL>	Age between 18 and 60; score in Voice Sympton Scale (VoiSS) equal to or less than 16; signing of the Informed Consent (IC).	Voice disorders diagnosed by otolaryngologist physician; smokers; presence below 75% in the meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:19
RBR-3jtgfh	Prophylactic antibiotic therapy indicated in reduction mammoplasty: clarifying its role in the prevention of surgical wound infection	Recruiting	Intervention	2016-05-28	<NULL>	<NULL>	867	Effectiveness of antibiotic prophylaxis in a single dose in the infection prevention on reduction mammoplasty surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-10	Hospital Agamenon Magalhaes	Hospital Agamenon Magalhaes	https://ensaiosclinicos.gov.br/rg/RBR-3jtgfh	<NULL>	woman, age from 18 to 70 years old, approved by the hospital medical joint comission; body mass index between 25 to 30	Using steroids ; have used antibiotics in the last 7 days prior to the surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7b7cmn	Clinical evaluation of the effect of the combination of Potassium Nitrate 5% and desensitizing agent-based glutaraldehyde in the prevalence of post-bleaching sensitivity	Recruiting	Intervention	2016-05-28	<NULL>	<NULL>	868	Clinical evaluation of the effect of the combination of Potassium Nitrate 5% and desensitizing agent-based glutaraldehyde in the prevalence of post-bleaching sensitivity	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2014-08-13	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7b7cmn	<NULL>	Candidates must have all the teeth of the upper and lower canine; canine without manifestations of caries and/or restorations; exposed dentin and spontaneous tooth sensitivity; able to sign a consent form; over 18 years; Commit to attend for regular examinations; having good conditions of oral and general health; central incisors to A2 or darker color.	Pacientes who have previously done some bleaching procedure; pregnant or lactating; smokers, patients with tetracycline stains, fluorosis or endodontic treatment; patients with severe periodontitis and bruxists; use of any medication with anti-inflammatory or antioxidant action.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-7tnhd8	Characterization of grisp strenth and manul skills of children with 5 to 10 years with Down syndrome.	Recruiting	Intervention	2016-05-31	<NULL>	<NULL>	876	Characterization of grisp strenth and manual dexterity of children with 5 to 10 years with Down syndrome.	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-19	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7tnhd8	<NULL>	"The child must be between 5-10 years and 11 months old; parents have signed a consent form freely Clarified and child Consent Term freely Clarified, the child has a diagnosis of Down syndrome.

The child must be between 5 to 10 years and 11 months old; parents have signed a consent form freely Clarified the child take part in the research by signing the Instrument of Consent Informed freely; the child is typically developing, presenting school grades above average (5.0) in two consecutive marking periods in the subjects of English Language, Mathematics and Physical Education; considered good students for the newsletter description given by school teachers / the classroom, be enrolled and attending regular network of public or private education."	"The child is less than five years or over 10 years and 11 months; parents / guardians and the child does not agree to participate in the survey; have different diagnoses of Down syndrome, present co-occurrences of diseases that are not characteristic of Down syndrome according to the guidelines of care for people with Down syndrome (MINISTRY OF HEALTH, 2013).


The child is less than five years or over 10 years and 11 months; parents / guardians and the child does not agree to participate in the survey; children have any involvement in its development or have a diagnosis that harms their performance in this study, such as learning disorders, syndromes, cerebral palsy, as well as having a history of prematurity and orthopedic surgeries in the upper limbs and are taking medicine which might jeopardize the manual skill of the child, such as psychotropic drugs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-96cjsh	Computer games on elderly socialization	Recruiting	Intervention	2016-05-31	<NULL>	<NULL>	879	Virtual Reality games on elderly socialization	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-96cjsh	<NULL>	All the elderly over 60 years, of both sexes, spontaneously enrolled in the informatics beginner class for seniors of the Reference certer of elderly in Ribeirão Pires.	Those who have less than 75% of frequency in the classes between the assessments and/or do not complete the three moments of assessment. Individuals with some motor impairment of the upper limbs, which prevents them to practice the games, will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-4qxt3z	Effect of different forms of electrical stimulation for pain relief in patients with low back pain: a randomized clinical trial	Recruiting	Intervention	2015-12-30	<NULL>	<NULL>	880	Effect of different forms of electrical stimulation in patients with low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-19	Hospital Universitário (HU) da Universidade Federal de Sergipe (UFS)	CNPq- Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-4qxt3z	<NULL>	Volunteers of both genders; aged between 20 and 55; to have nonspecific low back pain for at least 3 months ago; paid work for at least 8 hours per week	patients performing physical therapy or any other method of treatment, pregnant women or mothers who gave birth in the last 3 months; important deformities and / or amputations of lower limbs (LL); low back pain due to infections; tumors; osteoporosis; rheumatoid arthritis; vertebral fracture; radiculopathy or inflammatory processes; skin lesions in the affected region; and infections assets; other nervous or dermal tissue disease affecting the lower back; surgery or invasive examinations of the spine in the last 3 months; inability to understand the instructions or consent for the study; psychiatric diseases; neurological disorders (eg. stroke; Parkinson&apos;s; Alzheimer&apos;s; brain tumor; dementia; multiple sclerosis; substance abuse) or lung such as chronic obstruction oxygen dependent; which could seriously affect the test results; heart disease such as cardiac arrhythmia; angina pectoris; congestive aca card failure; decompensated hypertension; severe comorbidity; contraindication for the use of electroacupuncture, such wounds.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-283x55	Treatment efficacy for anxiety in obstetric elective procedures	Recruiting	Intervention	2016-06-08	<NULL>	<NULL>	884	Clinical and laboratorial treatment efficacy for general and preoperative anxiety in obstetric elective procedures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-07-21	Maternidade Escola da Universidade Federal do Rio de Janeiro	Instituto de Psicologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-283x55	<NULL>	pregnant women in 35th gestational week with single normal fetus; with indication for elective obstetric interruption; without  clinical and laboratory complications; normal cardiotocography; obstetric ultrasound without  abnormalities.	use of anxiolytic, sedative or psychoactive drugs;psychiatry disease;previous operative complications;multiple birth;fetal macrossomia;corticotherapy;infection;auricular lesion;high blood pressure symptomatic;gestational diabetes mellitus without control;acuteasthma;active labor;that are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:20
RBR-2bghmh	Clinical, blood, mobility and quality of life evaluation in people with metabolic syndrome after whole body vibration exercise in vibratory platform	Recruiting	Intervention	2016-06-14	<NULL>	<NULL>	890	Clinical, metabolic, functional and quality of life evaluation in people with metabolic syndrome after whole body vibration exercise in oscillating / vibratory platform	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-10	Programa de Pós Graduação em Fisiopatologia Clínica e Experimental	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2bghmh	<NULL>	Outpatients both genders; aging over 40 years; of the &quot;Hospital Universitário Pedro Ernesto&quot; (HUPE); with diagnosis of Metabolic Syndrome according the International Diabetes Federation.	Blood pressure higher than 180 x 110 mmHg; Cardiovascular disease in the last 6 months due to heart attack or stroke; Neurological, muscular or rheumatological disease that limit the movements on the oscillating/vibratory platform; Severe or incapacitant clinical disease; Patients that refuse to sign the Agreement Term to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-8y3sj9	Effectiveness and safety of colchicin crema 0,5% versus photodynamic therapy  in treating areas with precancerous lesions	Recruiting	Intervention	2016-06-16	<NULL>	<NULL>	893	Effectiveness and safety colchicine cream 0,5% versus photodynamic therapy wuith mehtyl aminolevulinate in treatment of skin field cancerization: a randomized clinical trialE	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-03	Faculdade de Medicina - Unesp Botucatu	Faculdade de Medicina - Unesp Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-8y3sj9	<NULL>	Sign the Statement of Consent. Age above 18 years of both sexes. Provide at least three and no more than ten clinically compatible with actinic keratosis lesions on each forearm.	"Lesions in fewer than three or greater than ten in each forearm.
Selected treatment area that has atypical clinical appearance or other extensive dermatoses forearms . 
Current and previous clinical diagnosis or evidence of other diseases .
Display hypersensitivity or allergy to any of subustâncias study . 
Patients using any topical or systemic immunosuppressive substance .
Use of other skin treatment.
Immunocompromised individuals .
Coagulation disorders .
Pregnancy suspected or confirmed.
Women of childbearing potential not using contraception.
Women breast-feeding ."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-5byjd7	Muscle exercises for weak elderly.	Recruiting	Intervention	2016-06-20	<NULL>	<NULL>	896	Resistance training in elderly women with sarcopenia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Ceilândia/ Universidade de Brasília	Faculdade de Ceilândia/ Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5byjd7	<NULL>	Old people, aged oven than 70 years old;  living in the community; retired, who do not perform regular physical activity (use of the IPAQ short version; with availability to participate in all stages of research.	presence of disabling orthopedic disease; current orthopedic disease in the past six months; decompensated blood pressure; sequel of neurological diseases, diabetic; obese (through corporal- mass index BMI); cognitive impairment moderate to severe evaluated by the mini- mental State Examination (MMSE); with moderate to severe depression evidence verified by the Geriatric depression Abbreviated Scale (GDS); in use of nutritional supplements to gain muscle mass or hormone replacement. Also the elderly who miss two consecutive days will be deleted.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-3rp6tz	Hyperbaric Chamber and Cardiorespiratory Changes	Recruiting	Intervention	2016-06-21	<NULL>	<NULL>	898	Hyperbaric Oxygen Therapy and Cardiorespiratory Changes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-3rp6tz	<NULL>	Adults (regardless gender); respiratory and cardiac stability; medical indication to the application of hyperbaric oxygen therapy.	difficulty in understanding and performing the activities; physical and emotional malaise during the pressurization; chest tube; pregnant; hyperthermia; history of seizures not treated; postoperative of head/neck and thoracic surgeries; spherocytosis carriers; claustrophobia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:21
RBR-8vkw87	Muscular Electrical Stimulation after Cardiac Surgery	Recruiting	Intervention	2016-07-05	<NULL>	<NULL>	906	Neuromuscular Electrostimulation in the Postoperative of Cardiac Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-21	Universidade Federal de Sergipe	Fundação de Beneficência Hospital de Cirurgia	https://ensaiosclinicos.gov.br/rg/RBR-8vkw87	<NULL>	Will be included in the study cardiac patients of both sexes; aged between 18 and 75 years old who are hospitalized for surgical treatment of Myocardial Revascularization and Valve exchange; being allocated to different groups.	Patients with some type of psychiatric condition; cognitive decline or dementia that could influence the communication process; the presence of musculoskeletal disorder or neuromuscular recent or unresolved that limits or precludes the ability to walk; mobility or functional capacity; hemodynamic instability (Mean Arterial Pressure &lt;60 mmHg or &gt; 120 mm Hg); dyspnea with oxygen saturation less than 90%; tachycardia or bradycardia; cardiac pacemaker carriers; individuals with dermatitis; damaged skin and sensitivity changes that preclude the application of NMES will be deleted from study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-823rst	Evaluation of application, safety and motor and cognitive effects of video game Nitendo Wii Fit Plus® in frail elderly	Recruiting	Intervention	2016-07-11	<NULL>	<NULL>	915	Evaluation of applicability, safety and outcomes motor and cognitive of video game Nitendo Wii Fit Plus® in frail elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-823rst	<NULL>	Frail elderly and pre frail will be selected with 60 or older, diagnosed with frailty syndrome according to the criteria of Fried. The elderly should not present neurological or orthopedic diseases that promote the inability to remain in bipedalism and wade; with normal or corrected visual acuity measured by Snellen chart; Good hearing is clinically assessed by the whisper of the test; who did not have previous experience with the Nintendo Wii Fit® and who accept sign the Informed Consent and Informed of the study.	The elderly will be excluded that during the study period, submit any clinical change that makes it impossible to perform physical exercises in standing position, as cardiorespiratory, orthopedic or neurological disorders; elderly unable to interact with the game; and in the second phase of the study will exclude elderly who are missing for more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-472gf3	Evaluation of the use of ketamine medication in the treatment of depressed or bipolar persons	Recruiting	Intervention	2016-07-11	<NULL>	<NULL>	917	Sublingual Ketamine in treatment of Mood Disorders	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Hospital São José	Hospital São José	https://ensaiosclinicos.gov.br/rg/RBR-472gf3	<NULL>	Volunteers who have any mood disorders and high risk of suicide; 16-59 years old.	Volunteers manifesting delusions or maniac symptoms to mental status examination or BPRS; an actual history of alcohol or substance dependence with recent use in the last 7 days except nicotine and benzodiazepines; an unstable or untreated medical disorder; severe exogenous intoxication; being pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:22
RBR-2gykb2	Effects of clown intervention on the psychological stress and fatigue in children and adolescents with cancer receiving chemotherapy	Recruiting	Intervention	2016-07-14	<NULL>	<NULL>	924	Correlations between immunological biomarkers and response to fatigue and psychological stress in children and adolescents with cancer undergoing chemotherapy submitted to clown intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-12	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2gykb2	<NULL>	Experimental group;Children and adolescents aged 2 to 18 years; of both sexes; diagnosed with malignant neoplasm; in any phase of chemotherapy; who present conscious, able to communicate verbally, reading and writing; Control group;Children and adolescents aged 2 to 18 years; with no history of chronic disease or autoimmune disease or psychiatric illness; followed up in one of the 5 Family Health Unitis; not be receiving medication at the time of selection or collection of biological samples; who present conscious, able to communicate verbally, reading and writing; presenting recent blood count data in normal levels;	Experimental group;Patients with a history of chronic disease or autoimmune disease or psychiatric disease; patients receiving radiotherapy; patients in palliative care; patients using antidepressants or drugs which altering the mood; patients with clownfobia; patients with infectious conditions in activity; patients in the immediate postoperative period; Control group;Children and adolescents with infectious conditions in course; presence of fever in the last 48 hours; in use of systemic corticosteroids, inhaled or topical in the last 15 days;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-5qs9gr	Study in Matão to prevent Stroke: preventing Stroke in city of Matão, Brazil	Recruiting	Observational	2016-07-18	<NULL>	<NULL>	927	Mapa: Stroke prevention in Matão	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Sociedade Matonense de Benemerência	Centro Neurológico de Pesquisa e Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-5qs9gr	<NULL>	All first ever stroke patients aged,  aged older than 18 years old; residents in Matão city.	Subjects living in other localities;  subjects with previous stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-9djsc7	Association between vestibular rehabilitation treatments for dizziness	Recruiting	Intervention	2016-07-19	<NULL>	<NULL>	930	Vestibular rehabilitation protocols association: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-02	Universidade Federal de Pernambuco	Hospital Agamenon Magalhães	https://ensaiosclinicos.gov.br/rg/RBR-9djsc7	<NULL>	Elderly both genders with vestibular complaints; aged between 60 and 80 years; hospital patients.	Seniors who underwent audiometry and vectoelectronystagmography; Elderly patients with vestibular complaints; seniors who are not embedded in vestibular rehabilitation program; do not have hearing loss and or hearing aids; noncarriers of psychiatric disorders; They do not have physical disabilities; wheelchair; amputees; do not use crutches; participants visual impairment grave; Elderly unable to understand verbal commands; elderly diagnosed with benign paroxysmal vertigo;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-8xttkv	Effect of stimulation of the senses in the head control in children with cerebral palsy	Recruiting	Intervention	2016-07-20	<NULL>	<NULL>	932	Influence of sensory stimulation in the head control in children with cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Educação Física/ Universidade de Brasília	Hospital da Criança de Brasília José Alencar	https://ensaiosclinicos.gov.br/rg/RBR-8xttkv	<NULL>	Children diagnosed with cerebral palsy classified V level Gross Motor Functional Classification System - GMFCS, aged 9 and 36 months.	1) Children who completed 36 months before the final evaluation; 2) associated syndromes; 3) seizures outside clinical control; 4) structural musculoskeletal deformities preventing the execution of motor intervention; 5) Total visual impairment; 6) hearing loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-8x8fd9	Low sugar diet combined with nasal administration of perillyl alcohol: strategy therapy for resistant Glioblastoma Multiforme  to chemotherapy and radiotherapy	Recruiting	Intervention	2016-07-21	<NULL>	<NULL>	934	Ketogenic diet combined with intranasal administration of perillyl alcohol: strategy therapy to refractory Glioblastoma Multiforme  to standard treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-05	Hospital Universitário Antônio Pedro	Hospital Universitário Antônio Pedro	https://ensaiosclinicos.gov.br/rg/RBR-8x8fd9	<NULL>	Men and women with recurrent glioblastoma multiforme; aged 20 to 65; standard therapy (chemotherapy and/or radiotherapy); inhalating perillyl alcohol.	Patients with neurological complications; terminal phase; discontinue diet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:23
RBR-47fqzk	Effects of Counseling in sedentary adults with ankylosing spondylitis	Recruiting	Intervention	2016-07-22	<NULL>	<NULL>	936	Evaluation of effects hacer sin Sedentary behavior counseling Adults with ankylosing spondylitis : a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-47fqzk	<NULL>	"Having diagnosis of ankylosing spondylitis, according to the criteria New York.
Age between 18 and 59 years.
Male."	"Be diagnosed with some form of physical or mental disability.
Patients on medications that alter bone metabolism , such as denosumab , teriparatide , strontium ranelate.
Patients with bone fracture history in the last 6 months.
Patients with metabolic bone diseases and / or diseases that alter bone metabolism , including hyperparathyroidism , chronic renal failure , metabolic acidosis and alteration of serious levels of calcium, phosphorus and magnesium. 
Patient presenting chronic decompensated and medical negative for physical activity."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-6dmh7d	Deep Water Running in reducing body weight, improved functional capacity and quality of life in obese	Recruiting	Intervention	2016-07-27	<NULL>	<NULL>	939	Effect of Deep Water Running in body composition, functional capacity and quality of life in pre-obese and obese adults: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-30	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-6dmh7d	<NULL>	Volunteers of both sexes; adults in the age group of 39 to 59 years of age; classified as pre-obese  and obesity I  according to the III Brazilian Guidelines on Obesity. Show good adaptation to the liquid medium; perform the entry; exit and walking in the pool independently, and adequately perform the Deep Water Running technique in interval training system (DWR-STI). All volunteers must submit prescription attesting to the absence of restrictive heart disease the practice of aquatic physical training.	"cardiorespiratory, musculoskeletal and neuromuscular diseases that impede the realization of the aquatic training program; as well as the following contraindications of aquatic physical therapy; hydrophobia; skin wounds and infectious diseases.
Volunteers may not have taken part in other physical training program for at least two months before the start of data collection, as well as carrying out other training or nutritional monitoring program for the aquatic intervention.
For those who use antihypertensive medications and therapy for hormone replacement therapy (HRT); will not be allowed to change in class and or drug dose. Each volunteer can have a maximum of 3 absences (10%) nonconsecutive during the intervention."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-3qx5gd	Organic responses to a videogame session in subjects affected by stroke	Recruiting	Intervention	2016-05-09	<NULL>	<NULL>	946	Acute Physiological Responses to Virtual Reality Games in Adults Affected by Stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-11	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3qx5gd	<NULL>	Both genders, aged over 30 years, having suffered a single stroke  in more than 6 months ago.	Obesity greater than grade II; presence of cognitive deficit; presence of cardiovascular disease that precludes exercises; inability to walk on a treadmill.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:24
RBR-9fpjh9	Nutritional Guidance Impact about Food Preservatives in Exams of Hemodialysis Patients	Recruiting	Intervention	2016-08-03	<NULL>	<NULL>	949	Nutritional Guidance Impact with Additives Food Restriction on Phosphatemia in Hemodialysis Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-08	Faculdade de Medicina de Botucatu - UNESP	Hospital das Clínicas de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9fpjh9	<NULL>	Patients aged over 18 years. Patients with chronic kidney disease treated by regular hemodialysis for at least 90 days. Phosphorus serum concentration above 5.5 mg/dL in the month prior to randomization as guidelines K-DOQI.	Impossibility of feeding orally in the last three months. Clinical complications that change the patient&apos;s appetite for more than a week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-3z77p9	The effect of manual therapy in the column on the autonomic nervous system in patients with muscle and joint pain	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	956	The effect of manipulative therapy on cardiac autonomic nervous system of musculoskeletal pain patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-10	Centro Universitário Augusto Motta	Hospital Universitário Gaffrée e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-3z77p9	<NULL>	Pacients in the physiotherapy sector at the Gaffrée and Guinle University Hospital that are experiencing musculoskeletal pain.	"Surgery on the thorax/spine location do not allow realizing the proposal technics; Pregnant women;
Rheumatologic diseases in acute inflammatory phase;Osteoporosis; Bone tumors; Pacemaker carrier; presenting cardiac arrhythmia or being transplanted heart; ingested foods and drinks which containing caffeine on the day of the experiment; consumed alcoholic drinks on the last 24 hours;
Illiterate or unable to fill the self-applied questionnaires."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-5cc79w	Effect of physical exercise on strength, muscle mass,  movement, functional capacity and inflammation in sarcopenic and non sarcopenic elderly	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	957	Effect of resistance training in muscle strength, muscle mass, mobility, functional capacity and biochemicals parameters in sarcopenic and non sarcopenic elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista	Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5cc79w	<NULL>	Individuals must be aged 60 or over; both genders; be clinically stable.	Inability to get around; being bedridden; musculoskeletal dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-99qw5h	Effects of body electrical stimulation after the stomach reduction surgery	Recruiting	Intervention	2016-08-12	<NULL>	<NULL>	958	Functional, clinical and systemic effects of the body electrical stimulation on bariatric surgery postoperative	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-99qw5h	<NULL>	This research will include obese (BMI 35 kg / m2) or morbidly obese (BMI 40 kg / m2) for at least three years or more without positive results to conventional treatments (pharmacological or not) aged 20 to 45 years will undergo surgery of Gastric Bypass (CBG). Patients with BMI&gt; 30 kg / m2 may also be included according to medical team decision regarding the presence of important comorbidities indicated by Brazilian Bariatric Consensus.	Exclusion criteria are volunteers with orthopedic or neurological impairments that unable participation in an exercise program; myocardial infarction (within the beginning of the six-month study period); implanted pacemaker or any metallic synthesis; unstable angina; chronic disorders of the heart rhythm; moderate or severe valvular heart disease; consistent story of heart disease; uncontrolled hypertension; uncontrolled diabetes mellitus and / or insulin-dependent; beta-blocker users; postmenopausal women and participation in a regular program of physical activity at baseline. It will be also excluded from the present study any COPD volunteers or patients presenting other respiratory diseases or who present any contraindication to cardiopulmonary exercise test or condition that may limit the performance of the functional tests; distal artery diseases; inflammatory diseases; kidney diseases; and liver diseases with documented diabetic neuropathy; cognitive impairment; difficulty in understanding and / or adherence to study procedures; reported using illicit drugs and pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-6fs48y	Occurrence and treatment of oral mucositis in subjects in the treatment of head and neck cancer	Recruiting	Intervention	2016-08-16	<NULL>	<NULL>	965	Polihexanide the effectiveness of evaluation in the treatment of oral mucositis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-10	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-6fs48y	<NULL>	Will be allocated to study cancer patients treated with any chemotherapeutic agent and / or radiotherapy in cervicofacial fields; aged over 18; treated in UNACON; who didn&apos;t have treatment for mucositis previously; that having read, understood and signed the Free and Clarified Consent Term (FCCT); and present oral mucositis or injury as a result of cancer treatment.	They will be excluded from the study: patients who refuse to participate in the study; under 18; already in treatment of mucositis; with an allergy to some component of the substances being applied in the study; who refuse to perform subsequent oral assessments; to discontinue the antineoplastic treatment for a period equal to or greater than 8 days; to suspend the use of the substances analyzed in the study; who are hospitalized terminally ill cancer; preventing the oral evaluations, and patients who come to death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-78rd57	Evaluating the use of peripherally inserted central catheter exclusively for parenteral nutrition	Recruiting	Intervention	2016-08-16	<NULL>	<NULL>	966	Evaluating the use of peripherally inserted central catheter exclusively for parenteral nutrition - randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-15	União Brasileira de Educação e Assistencia	Hospital Universitário de Santa Maria - HUSM	https://ensaiosclinicos.gov.br/rg/RBR-78rd57	<NULL>	All newborn UTINeo that the intern with prescription parenteral nutrition NP and indicating insertion of a peripherally inserted central catheter PICC for this purpose.	"RN diagnosed with clinical or laboratory sepsis according to the criteria of ANVISA 2010;
PICC RN in which the location is not in focus; 
Newborns with umbilical catheter; 
Check-list of PICC insertion procedure with scores below 10; 
Failure to obtain the consent of parents or guardians to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:25
RBR-38zssz	Daylight photodynamic therapy application in the treatment of a superficial skin carcinoma	Recruiting	Intervention	2016-08-24	<NULL>	<NULL>	971	Daylight photodynamic therapy application in the treatment of Bowen&apos;s disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-13	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-38zssz	<NULL>	Patients with clinical and histological diagnosis of Bowen´s disease at the Department of Dermatology of the Hospital de Clínicas de Porto Alegre.	Patients with allergy to medications under treatment; porphyria; pregnancy; lactation; lesions in area of difficult sun exposure; lesions with clinically-suggested invasive carcinoma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-3phy2q	ketorolac antiinflammatory effect associated with a combination of analgesic tramadol/acetaminophen after third molars surgery	Recruiting	Intervention	2016-08-24	<NULL>	<NULL>	973	Analgesic effectiveness of oral ketorolac associated with a combination of analgesics tramadol/acetaminophen after impacted third molars surgery: randomized and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3phy2q	<NULL>	&quot;Volunteers of both genders; aged 18 to 35 who have  indication of third molar elective extraction and look for treatment at the clinic of Dentistry; State University of Ponta Grossa. Each patient should have two impacted third molars in a similar position; symmetrical bilaterally; according to Pell  and Gregory and Miller Winter rating; and at least 1/3 of the formed root; according to radiographic evaluation; classified as class I or II, B and C Pell and Gregory. Patients must be healthy; without systemic changes and classified as ASA I; American Society of Anesthesiologist&quot;.	&quot;Patients with a history of hypersensitivity to ketorolac; pregnancy;  asthmatics; diabetics; lactation; hypertensive; patients with gastrointestinal disorders; myasthenia gravis or glaucoma are not included in the study. Immunosuppressed patients; dependent on narcotic drugs; patients with neurological and or behavioral changes; inflammatory users or antihypertensives continuously will also be excluded from the sample&quot;.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-52fq9q	Effect of the strategies of an orientation program of lifestyle and healing in patients with venous ulcers	Recruiting	Intervention	2016-08-31	<NULL>	<NULL>	976	Effect of the strategies of an orientation program of lifestyle and the process of healing in patients with venous ulcers: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-15	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-52fq9q	<NULL>	Characteristics of venous ulcer: clinical signs observed;Index ABI&gt; 0.8 and &lt;1.3; Over age 18; Venous Ulcer with a minimum of six weeks and &gt;0,2cm2 size; Treatment with inelastic compression therapy.	"Medical diagnosis of osteomyelitis;Patients with Diabetes Mellitus;
Patients with infected wounds;pregnant or breastfeeding; Patients with cognitive understanding of disability"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-46zk89	Effects of self-care rests on knowledge, self-care and metabolic control in adult men with diabetes mellitus	Recruiting	Intervention	2016-09-05	<NULL>	<NULL>	979	Effectiveness of self-care rests on knowledge, self-care and cardiometabolic control of adult men with Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-19	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-46zk89	<NULL>	"Having medical diagnosis of DM2.
Being male.
Age between 40 and 70 years.
Is domiciled in the city of Maringa in the FHS coverage area.
Being part of the ESF families register.
Being able to answer the questions of data collection instruments.
Relate visual ability, hearing and locomotor to perform self-care.
Have telephone contact (mobile or fixed) for monitoring the program."	"Present lesions in target organs (brain, heart, kidneys, eyes) or comorbidities/complications resulting from diabetes, recorded in medical records, such as chronic renal failure.
Have psychological or other disorders, registered in the medical records, and that compromise the understanding of the study, who do not agree or do not have availability to participate in the intervention.
Moving to another location that does not have coverage of the ESF, or even to another city."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-3pfcjs	Short film to promote self-care in people with diabetes and at-risk foot	Recruiting	Intervention	2016-09-05	<NULL>	<NULL>	980	Construction and validation educational video to promote people with diabetes and foot self-care at risk	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-20	Universidade Estadual do Ceará-UECE	Coordenadoria de Gestão do  Trabalho e Educação na Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3pfcjs	<NULL>	people with type 2 diabetes aged 40 years and older, of both sexes; with diagnosed type 2 diabetes for at least two years; registered; monitored regularly in these Primary Healthcare Units.	disoriented in time and space or presenting some difficulty that prevents them from communicating and answering the instrument.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-58ghgp	Evaluation of Biomarkers Associated With Response to Subsequent Therapies in Subjects With HER2-Positive Metastatic Breast Cancer	Recruiting	Intervention	2016-09-06	<NULL>	<NULL>	983	"EGF117165 - A phase II, open-label study to evaluate biomarkers
associated with response to subsequent therapies in subjects
with HER2-positive metastatic breast cancer receiving
treatment with Trastuzumab in combination with Lapatinib or
Chemotherapy"	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2016-01-04	GlaxoSmithKline Brasil	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-58ghgp	<NULL>	Female equal or more than 18 years; histologically or cytologially confirmed invasive breast cancer with distant metastasis; subjects must have at least one measurable lesion per RECIST 1.1 (Note: biopsied lesions should not be used as target lesions.); HER2 overexpression or gene amplification, in the invasive component of either the primary tumor or metastatic disease site as defined as: 3+ by Immunohistochemistry (IHC) and/or centrally determined HER2-positive, hormone receptor status, breast molecular subtype by prediction analysis of microarray 50 (PAM50) on the pre-treatment biopsy of metastatic lesion obtained during screening (Note: biopsied lesions should not be used as target lesions.); progression on at least 2 lines of anti-HER2-targeted therapies for metastatic breast cancer (MBC); documented radiological disease progression during the most recent treatment regimen for metastatic disease; most recent treatment regimen for metastatic disease must include Trastuzumab and chemotherapy (Note: Trastuzumab emtansine (T-DM1) is considered acceptable as prior Trastuzumab/chemotherapy regimen); agreement to provide 2 tumor biopsies; prior treatment with pertuzumab, Lapatinib, and/or Trastuzumab emtansine is allowed. However, the last treatment for MBC must not include Trastuzumab in combination with pertuzumab; subjects with radiographically stable central nervous system (CNS) metastases, defined as radiographically stable on the previous 2 brain imaging scans, asymptomatic, and off systemic steroids and anticonvulsants for at least 1 month are eligible; treatment with prophylactic anticonvulsants is permitted unless listed under prohibited medications; discontinuation of all prior chemotherapy, immunotherapy, or biological therapy at least 3 weeks prior to the first dose of investigational product is required (Note: discontinuation of Trastuzumab is not necessary); all treatment related toxicities, except alopecia, must have recovered to grade 1 or better (common terminology criteria for adverse events (CTCAE) version 4.0) prior to administration of the first dose of study treatment; baseline left ventricular ejection fraction (LVEF) equal or more than 50% as measured by echocardiogram (ECHO) or Multigated acquisition (MUGA) and above the testing institution&apos;s lower limit of normal; QT interval corrected (QTc) less than 450 millisecond (msec) or QTc less than 480 msec for patients with bundle branch block; women childbearing potential must have a negative serum pregnancy test within 7 days prior to the first dose of study treatment and agree to use effective contraception, during the study and for 30 days following the last dose of study treatment; Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; completion of screening and baseline assessments; able to swallow and retain orally administered medication and does not have any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels; at least 4 weeks must have elapsed since the last surgery and 2 weeks must have elapsed since radiotherapy; adequate baseline organ function as defined hereafter: absolute neutrophil count equal or more than 1.5 x 10^9/litre (L); hemoglobin equal or more than 9.0 grams/decilitre(g/dL) (after transfusion if needed); platelets equal or more than 100 x 10^9/L; albumin equal or more than 2.5 g/dL; serum bilirubin less than or equal a 1.25 x upper limit of normal (ULN)(these values must be independent of growth factor support and stable for at least one week post transfusion); alanine aminotransferase and aspartate aminotransferase (AST and ALT) less than or equal a 2.5 x ULN; calculate creatinine clearance more than or equal a 40 mL/min (with the exception of those subjects who have Gilbert&apos;s syndrome, the bilirubin in these subjects should be at their baseline).	Lactating female (Note: women with potential to have children must be willing to practice acceptable methods of birth control during the study); bone-only disease and/or disease that cannot be biopsied; unstable CNS metastases or leptomeningeal carcinomatosis not considered radiographically stable (Note: subjects with radiographically stable CNS metastases are defined as radiographically stable on the previous 2 brain imaging studies, asymptomatic, and off systemic steroids and anticonvulsants for at least 1 month; treatment with prophylactic anticonvulsants is permitted unless listed under prohibited medications); any serious and/or unstable pre-existing medical, psychiatric disorder, or other conditions including concurrent disease that could interfere with subject&apos;s safety, obtaining informed consent, or compliance with the study procedures; serious cardiac illness or medical condition including but not confined to: uncontrolled arrhythmias (e.g. ventricular tachycardia, high-grade atrioventricular (AV)-block, supraventricular arrhythmias which are not adequately rate-controlled); angina pectoris requiring antianginal medication; history of congestive heart failure or systolic dysfunction (LVEF &lt;50%); documented myocardial infarction &lt;6 months from study entry; evidence of transmural infarction on ECG; poorly controlled hypertension (e.g. systolic &gt;160milimiter (mm) mercury (Hg) or diastolic &gt;100mm Hg); clinically significant valvular heart disease; current active hepatic or biliary disease (with exception of subjects with Gilbert&apos;s syndrome, asymptomatic gallstones, liver metastases, or stable chronic liver disease per investigator assessment); any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bowels as well as subjects with ulcerative colitis are also excluded; any prohibited medication; prior treatment with Trastuzumab in combination with Lapatinib or prior treatment with an irreversible inhibitor of the intracellular domain of the HER2 receptor such as neratinib; last treatment for metastatic disease including Trastuzumab in combination with pertuzumab; administration of an investigational drug within 30 days or 5 half-lives, whichever is longer, preceding the first dose of study treatment; a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to any of the study drugs or their excipients that, in the opinion of the investigator or GSK medical monitor, contraindicates participation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-5dnmsk	Association of compounds as an alternative for the treatment of tooht with hypersensitivity	Recruiting	Intervention	2016-09-08	<NULL>	<NULL>	987	Association of monomers as an alternative for the treatment of dentin hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal de Santa Maria- UFSM	Universidade Federal de Santa Maria- UFSM	https://ensaiosclinicos.gov.br/rg/RBR-5dnmsk	<NULL>	Individuals healthy ; both genders; aged between 18 and 80 years; with clinical symptoms dentin hypersensitivity two permanent; teeth in different quadrants; with exposed cemento-enamel junction; without cavitation at the clinical examination	Tooht with carious lesions; defective restorations; erosion; post-operative sensitivity after periodontal treatment or bleaching; bruxism; pulpitis; root fracture; or other conditions that may cause or predispose to the development of dentin hypersensitivity; individuals with special; needs or cognitive impairment compromising data collection; minors (&lt;18y); pregnants; individuals undergoing treatment for dentin hypersensitivity in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:26
RBR-3t8prz	Pessary (cervical Ring) plus Progesterone to prevent Preterm delivery	Recruiting	Intervention	2016-09-08	<NULL>	<NULL>	990	Pessary plus Progesterone to prevent Preterm delivery in women with short cervical length: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	UNIVERSIDADE ESTADUAL DE CAMPINAS	UNIVERSIDADE ESTADUAL DE CAMPINAS	https://ensaiosclinicos.gov.br/rg/RBR-3t8prz	<NULL>	pregnant women between 18 weeks and 0 days and 22 weeks and 6 days of gestation with cervical length lower or equal 30 mm	Placenta previa diagnosed by US second or third quarter; greater than 1 cm cervical dilatation; painful uterine activity; active vaginal bleeding; cervical cerclage in the current pregnancy; cervical length &lt;5 mm; Rupture of Membranes; severe liver disease; cholestasis occurred while current pregnancy;  History or thromboembolic event during the pregnancy; monoamniotic Twin pregnancy; Multiple pregnancies with 3 or more fetuses; ultrasonographic signs of fetal-fetal transfusion; selective growth restriction diagnosis of type 2 or 3 Gratacós; Major fetal anomalies; Fetal death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-8nv3fg	Impact of pelvic floor phisiotherapy during pregnancy in urinary incontinence and delivery.	Recruiting	Intervention	2016-09-09	<NULL>	<NULL>	992	Relation among pelvic floor phisiotherapy during pregnancy, urinary incontinence and obstetric outcome.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-30	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8nv3fg	<NULL>	Pregnant between 12 and 20 weeks of pregnancy; without previous deliveries.	Diabetes; fetal malformation unfeasible to vaginal delivery; urinary incontinence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-84jx98	Assessment of the effects of TENS in patients with low back pain treated with acupuncture.	Recruiting	Intervention	2016-09-12	<NULL>	<NULL>	996	The assessment of the effects of analgesia in transcutaneous electrical stimulation associated with acupuncture in patients with chronic low back pain.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-10	Universidade Federal de Pernambuca - UFPE/ Brasil	Universidade Federal de Pernambuca - UFPE/ Brasil	https://ensaiosclinicos.gov.br/rg/RBR-84jx98	<NULL>	Patients aged from 40 years; both sexes; with a history of low back pain for more than three months.	In addition to not meet the inclusion, they will also be considered affected or carriers of any concomitant arthropathy; those who are undergoing cancer treatment; which have chronic diseases or changes in neurological examination as Parkinson&apos;s disease, Alzheimer&apos;s and Stroke rehabilitation. Also excluded are patients who do not accept (or their relatives) sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-3kzxsf	A placebo versus study medication trial study for verification of improving survival in metastatic colorectal cancer patients.	Recruiting	Intervention	2016-09-12	<NULL>	<NULL>	999	A phase III double-bblinded, placebo controlled study of xilonix™ for improving survival in metastatic colorectal cancer.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2015-09-29	XBiotech USA Inc	Clinipace Pesquisas Clínicas do Brasil Ltda. - CPWW	https://ensaiosclinicos.gov.br/rg/RBR-3kzxsf	<NULL>	Subjects with pathologically confirmed colorectal carcinoma that is metastatic or unresectable and which is refractory to standard therapy; to be considered refractory, a subject must have experienced progression (or intolerance) after treatment with at least all of the following agents: oxaliplatin, irinotecan, flouropyrimidine, and cetuximab or panitumumab if KRAS (retrovirus-associated DNA (desoxinucleic acid) sequences isolated from Kirsten murine sarcoma viruses) wildtype; subjects will not be treated with any radiation, chemotherapy, or investigational agents while enrolled in this protocol;  Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2; at least 2 weeks since the last previous cancer treatment including: chemotherapy, radiation therapy, immunotherapy, surgery, hormonal therapy, or targeted biologics and 4 weeks for patients who received treatment immediately prior to the study with anti-IL-1 (anti-interleukin 1) or anti-TNF (tumor necrosis factor) agents; age 18 years or older, male or female subjects; serum potassium and magnesium levels within Central Lab normal limits. Total serum calcium or ionized calcium level must be greater than or equal to the lower limit of normal. Subjects with low potassium, calcium and magnesium levels may be replenished to allow for protocol entry; adequate renal function; adequate hepatic function; adequate bone marrow function; for women of childbearing potential (WOCBP), a negative serum pregnancy test result at screening and monthly thereafter; for women who are not postmenopausal (24 months of amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to use adequate methods of contraception, during the treatment period and for at least 1 month after the last dose of study drug; signed and dated institutional review board (IRB)-approved informed consent before any protocol-specific screening procedures are performed; patients enrolled must, in the investigator’s judgment, be healthy enough to stay on the clinical trial for three months.	Mechanical obstruction that would prevent adequate oral nutritional intake; serious uncontrolled medical disorder, or active infection, that would impair the ability of the patient to receive protocol therapy; uncontrolled or significant cardiovascular disease; dementia or altered mental status that would prohibit the understanding or rendering of informed consent; subjects who have not recovered from the adverse effects of prior therapy at the time of enrollment to grade equal or lower than 1, excluding alopecia and grade 2 neuropathy; immunocompromised subjects; history of hepatitis B or C; history of tuberculosis; receipt of a live (attenuated) vaccine within 1 month prior to screening; subjects with history of hypersensitivity to compounds of similar chemical or biologic composition of xilonix; women who are pregnant or breastfeeding; WOCBP or men whose sexual partners are WOCBP who are unwilling or unable to use an acceptable method of contraception for at least 1 month prior to study entry, for the duration of the study, and for at least 1 month after the last dose of study medication; weight loss higher than 20% in the previous 6 months; history of progressive multifocal leukoencephalopathy or other demyelinating disease; subjects on immunosuppressive therapy, including transplant patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-4msydx	Perineal massage during pregnancy for prevention of perineal trauma	Recruiting	Intervention	2016-09-13	<NULL>	<NULL>	1004	Perineal Massage during pregnancy for prevention of perineal trauma at birth: quantitative and qualitative approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-12	Programa de Pós-graduação em Enfermagem da Universidade Federal de Santa Catarina - PEn/UFSC	Programa de Pós-graduação em Enfermagem da Universidade Federal de Santa Catarina - PEn/UFSC	https://ensaiosclinicos.gov.br/rg/RBR-4msydx	<NULL>	Pretend to give birth in one of the two participating hospitals; gestational age less than or equal to 35 weeks; single pregnancy, low risk pregnancy, with a live fetus; refer that she is available digital perineal massage daily 5 - 10 min; want to have vaginal delivery; ability to understand, read and speak in Portuguese; ability to understand the instructions of the perineal massage.	Previous cesarean section indication in labor; restriction of severe fetal growth; premature birth; elective cesarean indication ; fetal malformation; placenta previa; presentation not cephalic at birth; pre eclampsia; active genital herpes lesion after 34 weeks gestation; injury genital HPV at delivery; allergy almond oil; already be performing perineal massage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-57xtk7	Efficacy of a physical exercises protocol for legs in patients with venous chronic insufficiency	Recruiting	Intervention	2016-09-19	<NULL>	<NULL>	1006	Efficacy of a physical exercises protocol for lower limbs in patients with venous chronic insufficiency- Clinic trial randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-13	Universidade Federal do Rio Grande do Norte	Hospital Universatário Onofre Lopes- HUOL	https://ensaiosclinicos.gov.br/rg/RBR-57xtk7	<NULL>	individuals of both genders; aged between 35 to 69 years; diagnosed with Chronic Venous Insufficiency; ranked by criteria CEAP 2-6 without peripheral arterial disease associated, ankle index brachial between 1.3 and 0.9; with test ecco-doppler vascular venous	subjects who did not agree to participate in this study; who presented ulcers with a diameter greater than 4 cm or with clinical signs and / or confirmed diagnosis of infection; who are unable to attend the physiotherapy service twice a week and / or show inconsistent clinical manifestations with performing exercises such as congestive heart failure (class 3 or 4), angina, recent venous thrombosis, limiting musculoskeletal disorders or who have difficulty in understanding the activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:27
RBR-7zcp2n	Success of Endodontic Treatement of anterior teeth with Reciproc system instruments	Recruiting	Intervention	2016-09-20	<NULL>	<NULL>	1010	Reciproc system for the Endodontic Treatment of anterior teeth with Peripical Lesion	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-04	Universidade Federal de Sergipe	Universidade Estadual de Montes Claros - UNIMONTES	https://ensaiosclinicos.gov.br/rg/RBR-7zcp2n	<NULL>	Volunteers with anterior teeth presenting pulpal necrosis and radiographic evidence of apical periodontites whose diameter is higher than 2mm; that agree to paticipate and sign the informed consent sheet.	volunteers with teeth that will need crow placement due to advanced destruction; volunteers with a pre-existing health or oral condition that puts him at risk during the trial;  pregnant or breast feeding; volunteers with generalized periodontal desease or periodontal desease affecting the tooth to be included; volunteers allergic to any of the substances used during endodontic treatment; volunteers whose elegeble teeth has not completed its root formation, and , therefore, has an open apex; volunteers whose elegeble teeth presents radiogtaphic evidence of internal or external root resorption; volunteers whose elegible teeth has a calcified root canal space or has allready been submitted to root canal treatment; voluntters with a history of antibiotic, anti-inflamatory or analgesic use 15 days before endodontic treatment is to be performed; volunteers who have to have antibiotics prophylaxis due to bacterial endocarditis; volunteers whose elegible tooth has vital pulp tissue, even in the presence of a radiographic lesion; whose elegible teeth shows signs of root fracture during endodontic procedure; when accidents occur during endodontic procedure such as root perforation and file separation; teeth whose procedure can not be completed in a single visit due to incapacity to dry the canal (inflammatory exudate or heavy bleeding); patients that do not return to follow-up evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3d7yy4	Effect of Strength Training on the activation Myoelectric Respiratory, Structure Diaphragmatic, Pulmonary Function and Quality of Life in individuals with Heart Failure	Recruiting	Intervention	2016-09-22	<NULL>	<NULL>	1015	Effect of Strength Training on the Activation Myoelectric Respiratory, Structure Diaphragmatic, Pulmonary Function and Quality of Life in individuals with Heart Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3d7yy4	<NULL>	Patients must have a diagnosis of heart failure for at least six months; not have been admitted in two months; diagnosed as functional classes I, II, III, Second NYHA; left ventricular ejection fraction at rest &lt;45% rated by the echocardiogram; hemodynamic stability for at least two months; medication with optimal doses for at least two months; Body mass index (18.5 to 29.9 kg / m²); not present clinical history indicative of respiratory disease	Patients with worsening exercise tolerance or HF symptoms during the last 3-5 days; incapacidade de compreender ou realizar os exercícios; increase in body weight within 24 hours more than one kilogram; significant exercise-induced ischemia; present atrial fibrillation; decreased blood pressure&gt; 20 mmHg during exercise; Systolic pressure at rest&gt; 160 mmHg and diastolic&gt; 90 mmHg; Complex arrhythmias at rest or arrhythmias that develops with exercise; third-degree atrioventricular block; Resting heart rate&gt; 100 bpm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3yxds4	Effects of exercise training on the human body	Recruiting	Intervention	2016-09-22	<NULL>	<NULL>	1018	Time-course of organic adaptations in response to exercise training in aging	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas	Programa de Pós-Graduação em /gerontologia, Faculdade de Ciências Médicas, UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-3yxds4	<NULL>	Individuals from both sexes; non-active (frequency of regular physical activity less than two sessions per week); Did not participate in any regular training program over the last 6 months preceding the beginning of the experiment; to be normotensive, or grade 1 (systolic blood pressure: 140 to 149 mmHg or diastolic blood pressure: 90 to 99 mmHg), or 2 (systolic blood pressure 160 to 169 mmHg or diastolic blood pressure: 100 to 109 mmHg) of controlled hypertension (according to the medical report of the participants);  have clinical evaluation report carried out by a physician (general physical examination, cardiological and clinical exercise testing) authorizing the practice of physical activity.	Obesity greater than grade 2 (body mass index up to 35); coronary artery disease, diabetes mellitus insulin-dependent; chronic obstructive pulmonary disease; limiting osteoarticular disease; peripheral vascular disease; smokers; in use of medications that may interfere with physiological responses to tests, such as beta-blockers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3d7rp9	Is there difference to do respiratory exercise controlling the time or how often does it?	Recruiting	Intervention	2016-09-23	<NULL>	<NULL>	1019	Is there a difference in cardiorespiratory variables to prescribe the respiratory exercise by time or repetitions?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-05	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-3d7rp9	<NULL>	Availability of time for implementation of the proposed protocol; age equal to or greater than 18 years; both genders; healthy subjects; understanding and ability to perform respiratory tests.	Smoking Cessation; acute myocardial infarction; dizziness; altered ocular pressure; use of heart pacemaker; tympanic perforation; lung diseases (restrictive, obstructive or mixed) or systemic disease involving the respiratory and cardiac and neurological system; the absence of one or more times during the protocol; intense physical exercise for more than three time for week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6t4qmn	self-care economic evaluation of patients with type 2 diabetes mellitus	Recruiting	Intervention	2016-09-23	<NULL>	<NULL>	1020	Pharmacotherapeutic strategy for individual empowerment of patients with diabetes mellitus type 2 - pharmacoeconomic analysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-15	Universidade Federal São João Del-Rei	Universidade Federal São João Del-Rei	https://ensaiosclinicos.gov.br/rg/RBR-6t4qmn	<NULL>	Group Intervention: Patients with DM2 registered HIPERDIA. Aged 18 years. Both sexos.Residentes in the areas of coverage of ESFs belonging to the study. Graduates of EIEF. Low and moderate cardiovascular risk, according to the Framingham score. Control Group: Patients with DM2 registered HIPERDIA. Age less than 18. Both sexes. Residents in the areas covered by ESFs belonging to the study. No participant in any meeting of EIEF. Low and moderate cardiovascular risk, according to the Framingham score.	Group Intervention: Participants from other intervention projects related to DM. reduced cognitive ability, classified by the team of the FHS, as unable to reproduce the transferred information. Control Group:Indivíduos participants from other intervention projects related to DM. Patients with reduced cognitive ability, classified by the ESF team, as unable to reproduce the transferred information. Patients without result HbA1c in the reference period for data collection the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-6hbztw	Use of block of beta tricalcium phosphate to enhance the bone disponibility for the implants placement	Recruiting	Intervention	2016-09-28	<NULL>	<NULL>	1022	Use of block of beta tricalcium phosphate to enhance the bone disponibility in edentulous alveolar ridges: A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-02-01	Faculdade de Odontologia de Araraquara-Unesp	Faculdade de Odontologia de Araraquara-Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6hbztw	<NULL>	Having aged between 18 and 60; presence of edentulous alveolar ridges of less than 4 mm thick, which characterizes the need to increase bone availability for subsequent implants placement; good systemic health; provide at least 1 year of healing of the dental post-extraction socket.	Smokers and former smokers; diabetes;chronic or aggressive periodontitis ; users of medications wich alters the bone metabolism; cronical users of anti-inflammatories and antibiotics; bruxism; alcoholics; chemical dependents; pregnant or who wish to become pregnant in the next year; history of radiotherapy  in the head and neck regions; patients with diseases affecting bone metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-3qqkss	Effect of exercise on strength and balance of diabetic patients	Recruiting	Intervention	2016-09-30	<NULL>	<NULL>	1024	Comparative evaluation of the effect of aerobic, resistance and combined training on muscle strength and balance in individuals with type 2 diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3qqkss	<NULL>	Individuals with type 2 diabetes mellitus; diagnosis of diabetes for at least 3 years; with diabetic neuropathy; both sexes; aged 50 years; sedentary; able to walk without assistance or supervision from others;	Presence macroangiopathy; history of neurological diseases, muscular rheumatism or outside the etiology of diabetes; presence of uncontrolled hypertension; lack the physical activity program; smokers; dependent on alcohol and illicit drugs; change in the use of corticosteroids, oral hypoglycemic agents or any hypoglycemic diet two months before the start of the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-9gnxv3	Influence of different treatment forms with low temperature on the muscle and heart function in recovery after effort	Recruiting	Intervention	2016-09-30	<NULL>	<NULL>	1025	Influence of different cryotherapy protocols on muscle performance and cardiac autonomic modulation in acute post-effort recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9gnxv3	<NULL>	Healthy; male; aged between 18 and 35 years; students in undergraduate or postgraduate public higher education institutions or private.	Presence of musculoskeletal injury in dominant leg in the last two months; Raynaud&apos;s disease; allergies to cold; labor or physical activity that requires effort level in intensity that makes it impossible to volunteer at the time of survey participation is in muscular condition of homeostasis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-59ygr8	Applications of physioterapy equipments in low back pain	Recruiting	Observational	2016-06-14	<NULL>	<NULL>	1026	Application of electrothermotherapies resources in patientes with lumbar pain	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-59ygr8	<NULL>	localized lumbar pain; pain analogic visual scale (AVS) more than ; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology.	"Physical activity people with more than 6 weeks
It has been realized lumbar surgery; it not have clinical diagnosis of lumbar pain and when the ethiology was not known; it don´t show irradiated lumbar pain to gluteus and lower limbs, thermic and sensibility alteration, pregnant woman, kidney problem; patients with pace marker; skin lesions; patients who utilized analgesic medication before 48 hours of application of resource."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:28
RBR-555p8y	Heart function during the bed bath of people with acute myocardial infarction	Recruiting	Intervention	2016-10-06	<NULL>	<NULL>	1030	Oxygen uptake by myocardial and hemodynamic aspects during the bed bath of patients with acute myocardial infarction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal Fluminense	Hospital Icaraí	https://ensaiosclinicos.gov.br/rg/RBR-555p8y	<NULL>	Patients sub-group with acute myocardial infarction: Acute Myocardial infarction confirmed by myocardial necrosis markers Dosage (CK-MB and / or troponin), electrocardiogram (ECG) and echocardiogram Up to 48 hours of pain home chest; Older than 18 years; Killip 1 and 2. Subgroup of patients without cardiac involvement diagnosis: Patients admitted to the search scenario For hospitalization Cause not cardiac and without medical diagnosis of cardiovascular disease.	Sub-group of patients with acute myocardial infarction: Patients undergoing cardiac surgery; Chronic heart failure; septic shock; Regurgitation of the aortic valve or defective septum; severe aortic Sclerosis, aortic prosthesis; severe hypertension (MAP greater than 130 mmHg); tachycardia with high heart rate at 200bpm; a height 120 cm or greater than 230cm; weight less than 30 kg or more than 155kg; presence of aortic balloon. Subgroups of patients without cardiac involvement diagnosed: burns, dermatitis and / or polytrauma.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-6tbygn	The effect of electrical stimulation in people with shoulder pain	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1032	The effect of electrical stimulation point microcurrent in individuals with Chronic Myofascial Pain Syndrome in the upper trapezius muscle	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6tbygn	<NULL>	Individuals aged 18 to 40, that are experiencing persistent, spontaneous pain in the upper trapezius muscle region for more than 3 months. On physical examination, individuals must have at least one active trigger point in one or both sides of the muscle. The inclusion criteria for the presence of active trigger point in upper trapezius muscle are: Presence of a palpable taut band in the muscle; Presence of a hypersensitive lump in the taut band of muscle; Standard playback typical trigger point referred pain in response to palpation; Standard spontaneous presence of typical referred pain and / or recognition that pain patient and family; Pain of at least 3 cm on a visual analogue scale (VAS) from 0 cm (no pain) to 10 cm (worst pain imaginable).	Individuals that are experiencing muscle pain due to fibromyalgia; cervical radiculopathy; neck pain; degenerative cervical changes; History of surgery in the cervical spine or shoulder; history of fracture; Tendinitis in the neck and shoulder area; Cancer; Cervical myelopathy; atypical facial neuralgia; myopathy; Rheumatism; Multiple sclerosis; Tuberculosis; recent medication change; Use of anti-inflammatory or pain medications; physical therapy interventions (acupuncture, chiropractic, massage); weight lifters; Other chronic pain conditions (chronic fatigue syndrome and Lyme disease); cardiac pacemakers; Pregnancy; Menstrual period; uncontrolled hypertension; neurological or psychiatric disorders; Disorders of the skin and vascular disorders; sensitivity changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-22vxvq	Effect of stimulation with electrical current associated with exercise in stroke: randomized controlled clinical trial	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1034	Effect of interferential current associated with exercise in stroke: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-31	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-22vxvq	<NULL>	Patients with stroke in mild or moderate spastic phase, both genders, aged 30 to 70 years and without physical therapy concomitant during the training period.	Patients who present score less than 24 on the Mini-mental exam, psychiatric condition, cognitive decline or dementia influencing the communication process, musculoskeletal, neuromuscular, or recent cardiopulmonary disorder, patients who can not walk and sit independently, present anesthesia in the trunk region or refuse to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-83wwpx	Assessment of the influence of the use of live microorganisms on the absorption and production of soy isoflavone substances in women with menopausal symptoms	Recruiting	Intervention	2016-10-14	<NULL>	<NULL>	1037	Assessment of the influence of probiotics in absorption and production of soy metabolites in menopausal women with climateric symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-14	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83wwpx	<NULL>	Women between 40 and 60 years of age; latest menstrual period has occurred at least 12 months previously; follicle-stimulating hormone (FSH) levels are higher than 40mIU/mL; estradiol levels are lower than 20 pg/ml;currently present symptoms of estrogen deprivation.	History of chronic conditions such as Type 2 diabetes mellitus; cardiovascular or gastro-intestinal disorders; contraindications to hormone replacement therapy; soy-intolerant; vegetarians; undergone bariatric surgery; undergone hysterectomy; undergone hormone replacement therapy; oral contraceptives; antibiotics or lipid-lowering drugs in the previous 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-4k5mtn	Human semen freezing : Effects of adding lipids and antioxidants in the quality of sperm	Recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1039	Human semen cryopreservation: effect of lipid and antioxidant supplementation on sperm viability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-20	Faculdade de Medicina de Ribeirão Preto	Invitra	https://ensaiosclinicos.gov.br/rg/RBR-4k5mtn	<NULL>	Men aged 18-40 years; able to collect the semen by masturbation ; are prior to sexual abstinence of at least two days	Semen volume smaller than 1.5 ml; concentration less than 15 million sperm / mL ; motility less than 32 %	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7qgnbn	Effects of actions to promote healthy eating and physical activity using internet technology on the health of adolescents	Recruiting	Intervention	2016-10-17	<NULL>	<NULL>	1040	Effects of promotional activities of healthy eating habits and physical activity in adolescents, use of E-Health technology, enrolled in schools based public schools in the city of Salvador-BA	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-08-29	Escola de Nutrição - Universidade Federal da Bahia	Faculdade de Farmácia - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7qgnbn	<NULL>	Adolescents 10-17 years; of both sexes; enrolled in the public school system in Salvador-Bahia	Pregnant women and people with physical trauma (fixed at the time of anthropometric measurements) and systemic diseases and birth frames, except for metabolic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-7jcvv4	Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529	Recruiting	Intervention	2016-10-19	<NULL>	<NULL>	1044	AMB114588 - An open-label, long term extension study for treatment of Pulmonary Arterial Hypertension in paediatric patients aged 8 years up to 18 years who have participated in AMB112529 and in whom continued treatment with Ambrisentan is desired	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2011-06-21	GlaxoSmithKline	GlaxoSmithKline Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7jcvv4	<NULL>	Volunteers who participated in the study AMB112529; with diagnosis of Persistent  Pulmonary Arterial Hypertension;  Male or female;	Subjects who were withdrawn from ambrisentan in Study AMB112529;subjects with severe renal impairment;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-6v9sjj	Effects of physical exercise in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2016-10-19	<NULL>	<NULL>	1045	Effects of elastic resistance training on morphological and functional parameters in patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-04-01	Universidade Estadual Paulista Júlio Mesquita Filho	Universidade Estadual Paulista Júlio Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6v9sjj	<NULL>	Patients must have a diagnosis of chronic obstructive pulmonary disease; both genders; tifennau index less than 70 percent; be aged between 45 and 70 years; being clinically stable.	Cardiac comorbidities and musculoskeletal disorders; exacerbation within one month of the initial evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:29
RBR-2nzf7q	Effects of intense cycling and/or strength training on health-related blood parameters in type 1 diabetes mellitus patients	Recruiting	Intervention	2016-10-20	<NULL>	<NULL>	1050	Effects of high-intensity interval training and/or strength training on inflammatory, oxidative stress and glycaemic metabolism in type 1 diabetes mellitus patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-26	Universidade Federal do Rio Grande do Sul	Instituto da Criança com Diabetes	https://ensaiosclinicos.gov.br/rg/RBR-2nzf7q	<NULL>	Patients with type 1 diabetes mellitus(diagnosis for over five year); physically inactive (less than 150 min weekly systematic exercise in the previous three months); with glycated haemoglobin less than 10%; age between 18-40 years.	Smoking patients; they with significant loss of renal function (creatinine &gt; 1.3 mg/dL), liver failure, musculoskeletal disorders; hypertension; heart diseases; patients with retinopathy and/or recent infections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-67hjmn	Use of treatment with low power laser in canker sores and skin burns caused by radiation therapy in patients with head and neck cancer	Recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1051	Use of low level laser therapy for treatment of radiation induced mucositis and radiodermatitis in patients with head and neck cancer	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-20	Univesrsidade Estadual de Montes Claros	Univesrsidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-67hjmn	<NULL>	Individuals with a confirmed histopathologic diagnosis Squamous cell carcinoma of head and neck; 2) Individuals should have at least 20 years old; Need of radiotherapy treatmentd; Agreement to participate in the study, signed the consent form.	Individuals who are not able or have limitations that prevent them from responding to questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-89ydgj	Effects of interventions with and without interactive video games in children with developmental coordination disorder	Recruiting	Intervention	2016-10-21	<NULL>	<NULL>	1055	Comparative analysis of the effects of intervention with and without virtual reality on the motor performance and the energy expenditure in children with developmental coordination disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-89ydgj	<NULL>	"To study the initial stage will be included children of both sexes; aged 7-10 years; who are enrolled in selected schools; whose parents have signed the Consent Agreement and Informed and children the Free Consent Term Cleared up.
For the later stage of the study children will be included from the group of those with a positive indication for TDC; which have availability to participate regularly from interventions."	At this early stage of DCD tracking will be excluded children who have a physical disability; intellectual and or sensory impairments; autism spectrum disorder; orthopedic problems or other medical condition that may compromise the identification of the DCD. Children will be excluded if they do not meet the minimum of 10 intervention sessions; showing some clinical complications or making use of drugs that precludes their participation in training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-96sw76	Physiotherapy resources in the treatment of localized fat	Recruiting	Intervention	2016-11-16	<NULL>	<NULL>	1068	Electrothermalphototherapy agents in the treatment of the Body Disharmony Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-96sw76	<NULL>	Healthy volunteers; women; aged 18 to 40; sedentary; with the presence of fat located in the abdominal area.	Women in diet; with smoking and drinking habits; women using drugs for weight loss, steroids, progesterone and diuretics; pregnant women; mothers less than one year, women who have electronic monitoring; women with metal implants in the pelvic area; women who are in dermatofuncional treatment on site; surgery and / or radiation therapy for less than 6 months of the abdominal / pelvic area; women suffering from lymphatic system disorders, thrombophlebitis, acute infection, central nervous system diseases, tumors and diabetes, abnormal sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:30
RBR-494r9r	Comparison of two methods of complete denture fabrication	Recruiting	Intervention	2016-11-18	<NULL>	<NULL>	1070	Traditional versus simplified method for complete denture fabrication in edentulous patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-494r9r	<NULL>	Complete Edentulism (mandible or maxilla) for at least one year; Receptive and mentally agile; Availability to attend evaluations during the study period.	Uncontrolled systemic diseases; Temporomandibular disorders; Surgical Procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-67xf25	Effects of Auriculotherapy and Midazolam in anxiety control in patients submitted to extraction of third molars	Recruiting	Intervention	2016-11-21	<NULL>	<NULL>	1072	Effects of Auriculotherapy and Midazolam in anxiety control in patients submitted to exodontics of third molars	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-30	Universidade Federal de Sergipe - UFS	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-67xf25	<NULL>	exodontia indication of third molar; asymptomatic; positions and similar surgical difficulties; classified as 2B Pell &amp; Gregory (1942)	under 18 years of age patients; patients classified as ASA III or IV; drug use history for pain or anxiety in the 15 days before the beginning of the study; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnancy or lactation; previous history of pericoronitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-22rh3p	Non-invasive brain stimulation and physical training in stroke patients with motor impairments	Recruiting	Intervention	2016-11-21	<NULL>	<NULL>	1074	Transcranial Direct Current Stimulation and physical training in chronic stroke patients with motor impairments	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-16	Laboratório de Atividade Física e Promoção da Saúde - Instituto de Educação Física e Desportos - Universidade do Estado do Rio de Janeiro	Laboratório de Pesquisas Clinicas e Experimentais em Biologia Vascular	https://ensaiosclinicos.gov.br/rg/RBR-22rh3p	<NULL>	Volunteers of both sexes with hemiparesis, with at least six months of the occurrence of the the stroke; able to wander unsupervised for home march; enrolled in neuromotor rehabilitation program; with score above 36 on the Berg Balance Scale; with a minimum score of 20 on Fulg -Meyer scale; age between 18 to 80.	Patients which having any motor impairment that prevents the tests proposed and / or not controlled co-morbidity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-9rjg3g	5-fluorouracil 5% compared to vitamin b3 in the treatment of precancerous skin changes	Recruiting	Intervention	2016-11-24	<NULL>	<NULL>	1077	5- fluorouracil 5% intermittent versus nicotinamide at the treatment cancerization skin field: a clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-26	Faculdade de Medicina de Botucatu - UNESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9rjg3g	<NULL>	Age above 18 years of both sexes; provide at least three and no more than ten clinically compatible with actinic keratosis lesions on each forearm bilaterally.	Selected treatment area that has atypical clinical appearance or other extensive dermatoses forearms; current and previous clinical diagnosis or evidence of any medical condition that expose the patient to increased risk, interfere with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances under study; use of topical or systemic immunosuppressive substance, oral retinoid, and other local treatments (eg corticosteroids, anti-inflammatories, retinoids); immunocompromised; pregnancy suspected or confirmed; women of childbearing potential not using contraception; women in breastfeeding; coagulation disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-3fgwc7	Treatment through electrical stimulation and exercises for urinary incontinence	Recruiting	Intervention	2016-11-30	<NULL>	<NULL>	1080	"Pelvic floor training in urinary incontinence comparing techniques
treatment by intravaginal electrical stimulation and kinesiotherapy"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Pontifícia Universidade católica do Rio Grande do Sul	Pontifícia Universidade católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3fgwc7	<NULL>	Women; with urinary incontinence	Patients with severe lung disease; patients with severe heart disease; patients with neurological diseases; patients with oncological diseases; patients using antidepressant medications in general; patients who have pelvic organ prolapse above the second stage by POP-Q classification; pacemaker users; patients who have undergone surgical intervention for correction of urinary incontinence; patients to initiate any kind of physical activity structured and planned, in addition to those provided for in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-2v6ghb	Laser effectiveness in the treatment of local and distant pain in temporomandibular disorder	Recruiting	Intervention	2016-12-01	<NULL>	<NULL>	1082	Effect of low-level laser therapy in nociceptive local and corporal points in temporomandibular disorder: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-20	Faculdade de Odontologia de Ribeirão Preto (FORP) - Universidade de São Paulo	Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP)	https://ensaiosclinicos.gov.br/rg/RBR-2v6ghb	<NULL>	Women&apos;s volunteers; reporting pain in the facial area for at least 03 months; diagnosed with myofascial pain (temporomandibular disorder) according to the criteria of the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD - this diagnosis will be established after an evaluation with the researchers team).	Women&apos;s volunteers who are in any type of treatment for temporomandibular disorder; who have tumor, trauma or head/neck surgery history; previous diagnosis of fibromyalgia and other painful musculoskeletal syndromes (rheumatic diseases, among others); presence of neurological and/or psychiatric disorders; volunteers who use prescription drugs (anxiolytics, antidepressants, and/or anticonvulsants); pregnant women; users of heart pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-76t2gs	Effect of comparison of stretching and muscle release technique on posterior stiffness of shoulder in professional handball athletes	Recruiting	Intervention	2016-12-06	<NULL>	<NULL>	1088	Effect of stretching the comparison and mobilize myofascial technique in posterior shoulder tightness in professionals handebol athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-22	Universidade Federal de São Paulo	Centro de Traumatologia do Esporte - CETE	https://ensaiosclinicos.gov.br/rg/RBR-76t2gs	<NULL>	Inclusion criteria were established most athletes aged; at least two years of practice; reporting pain or not the shoulder; with ADM limitation	Exclusion criteria were established athletes with anatomical abnormalities; recent history (in the past 6 months) of upper limb injuries; subscapular nerve damage and previous shoulder surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-8hfqsm	Screening of patients with hypercholesterolemia  caused by family origin: development of a method for identifying genetic mutations that cause the disease and association between genetic and clinical characteristics of patients	Recruiting	Observational	2016-12-07	<NULL>	<NULL>	1092	Cascade screening of familial hypercholesterolemia from the development of a genotyping method and association of patients genotype and phenotype	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-23	Edson Luiz da Silva	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8hfqsm	<NULL>	Individuals with concentration of low density lipoprotein cholesterol above 160 mg / dL, and their relatives first, second and third degrees. Both genders.	Not include exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:31
RBR-48mvdx	The effect of toothpaste with active oxygen  in reducing of dental plaque.	Recruiting	Intervention	2016-12-16	<NULL>	<NULL>	1102	The effect of active oxygen on dental dentifrice in reducing supragingival biofilm:  randomized clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2016-06-16	Universidade Positivo	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-48mvdx	<NULL>	Healthy volunteers; aged between 18 and 35 years; a minimum of 28 teeth; no dental cavities; no  periodontitis and  established gingivitis.	antibiotic therapy three months before the study, using braces, motor difficulty, smoking and lack of commitment to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-45c8br	Study of the effects of manual lymphatic drainage in water and electrolytic mobilization and heart rate alteration in women in the reproductive and climacteric phases compared to the same parameters in men	Recruiting	Intervention	2016-12-19	<NULL>	<NULL>	1105	Study of the efficacy of manual lymphatic drainage in hidroelectrolytic mobilization and heart rate variability in women in the reproductive and climacteric phases compared to the same parameters in men	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-03-10	Instituto de Biologia Unicamp	Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-45c8br	<NULL>	ormotensos; Eutrophic (normal weight); Not having cardiovascular or respiratory system anomalies; Of endocrine diseases; Non-smoking and non-alcoholic; For perimenopause population may be included voluntary overweight; Self-declared healthy; For the young age group of 18-30 years; Perimenopause age range of 40-50 years.	Presence of acute infections and inflammations; phlebitis; thromboses or thrombophlebitis; hyperthyroidism; cardiopathies; chronic renal diseases; metaplasias and immune disorders; hypersensitivity of the carotid sinus; Use of diuretic medications; antidepressants; anxiolytics or any other medicinal treatments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-3jtxjs	Assessment pityriasis versicolor´s treatmenmt comparing Ketoconazol 2 % cream with Benzoyl Peroxide cream 5% isolateds and with these two together in cream	Recruiting	Intervention	2015-09-27	<NULL>	<NULL>	1107	Randomized double blind clinical trial to compare Ketoconazol 2 % with Benzoyl Peroxide 5% isolatedly and one of  them isolatedly with both together in Pityriasis Versicolor treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Universidade Federal de Pernambuco	Tárcio dos Santos Pereira	https://ensaiosclinicos.gov.br/rg/RBR-3jtxjs	<NULL>	Voluntary, mael or femael; age 18 years old or more who has clinical  of pityriasis versicolor and agree to take part in the study by consent information term	Patients who referring positive HI;, diabetic; pregnant; patient who taken immunossupressor&apos;s drugs; patients with allergic history to any drugs of the study; patients that have antimycotic in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-4n26tf	Evaluation of the Use of Guaco Syrup for Dilation and Reduction of Inflammation in the Respiratory Tract Through Pulmonary Function Tests in Asthmatic Volunteers	Recruiting	Intervention	2016-12-20	<NULL>	<NULL>	1108	Evaluation of bronchodilator and anti-inflammatory activity of guaco syrup in humans by pulmonary function tests in asthmatics volunteers	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade federal do paraná	Hospital de clínicas da universidade federal do paraná	https://ensaiosclinicos.gov.br/rg/RBR-4n26tf	<NULL>	Moderate persistent asthm (according to the classification criteria included in the IV Brazilian Guidelines for Asthma Management); aged between 18 and 60 years; diagnosis of asthma performed by spirometry (FEV1 / FVC &lt;90%, with FEV1 being forced expiratory volume in 1 second and FVC functional vital capacity).	Volunteers who had a stroke or acute myocardial infarction in the last three months; aortic aneurysm; systolic blood pressure higher than 200 mmHg or diastolic blood pressure higher than 90 mmHg; epileptics; unable to understand the procedure and implications of the study; with induced bronchoconstriction by recent spirometry; recent airway infection (during the last six weeks); during or near an asthma exacerbation; pregnant or breastfeeding women; in use of cholinesterase inhibitors; and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-2hx7p2	Comparison of the effects of two anesthetic protocols on the glycemic levels of patients undergoing extraction.	Recruiting	Intervention	2016-12-21	<NULL>	<NULL>	1109	Comparison of the effects of 2% lidocaine solutions with adrenaline 1: 100,000 and prilocaine 3% with felipressin 0.054 iu / ml in concentrations of blood glucose during exodontia.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-26	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2hx7p2	<NULL>	Patients older than 18 who will sign the TCLE; Medication-controlled diabetes mellitus; Patients in need of a simple exodontia in the mandible region using as an anesthetic technique the blockage of the inferior and buccal alveolar nerve; Surgical difficulties similar.	Patients under 18 years of age; Any general health problems, based on medical history and physical examination;History of use of any type of medicine in the 15 days prior to the beginning of the research;History of hypersensitivity to drugs, substances or materials used in this experiment;Pregnancy or lactation;Anatomical location of the tooth unfavorable to the inferior alveolar and buccal nerve block.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:32
RBR-8d2s62	Analysis of the results obtained in the post-operative surgery where an implant replaces the knee joint	Recruiting	Intervention	2015-09-02	<NULL>	<NULL>	1113	Clinical analysis of new knee prothesis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-12	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Ortopedia e Traumatologia	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Instituto de Ortopedia e Traumatologia	https://ensaiosclinicos.gov.br/rg/RBR-8d2s62	<NULL>	Healthy participants; both sexes;  60 to 70 aged years; with a diagnosis of osteoarthritis of grade IV and V according to Ahlback classification modified by Keyes; not have performed arthroplasty knee surgery earlier; failure of nonsurgical treatment (medication or physical therapy); not psychiatric disorders; not have diseases that have bone loss; not have chronic diseases including rheumatic diseases; not an alcoholic.	Participants with serious injuries in the operated knee; have deep infection; deep vein thrombosis without control with medical treatment; leaving treatment or follow-up; participant who no longer wish to perform the stipulated protocol; participant&apos;s death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-6dk3y3	Effect of interferential current combined with exercise in patients with fibromyalgia: randomized clinical trial	Recruiting	Intervention	2016-12-27	<NULL>	<NULL>	1115	Effect of interferential current combined with exercise on fibromyalgia: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6dk3y3	<NULL>	Patients with fibromyalgia, diagnosed according to the criteria of the American College of Rheumatology, female, aged 18 to 60 years, without physical therapy concomitant.	Subjects will be excluded if they have concomitant rheumatologic disease, severe psychiatric disorders or any contraindication to prevent the use of interferential current, such as allergies to the electrodes, cardiac pacemaker, pregnancy, epilepsy, skin conditions or deficient skin sensation in the areas of electrode placement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-26pms3	Rehabilitation in chronic obstructive pulmonary disease	Recruiting	Intervention	2016-12-27	<NULL>	<NULL>	1116	Rehabilitation in chronic obstructive pulmonary disease - functional, cognitive and epigenetic aspects	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2014-04-01	Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-26pms3	<NULL>	Patients with moderate to very severe chronic obstructive pulmonary disease;  of both genders; presenting clinical stability in the month prior to the beginning of the protocol and aged 40 years or more.	Current smoking; associated diseases that preclude the achievement of some of the evaluations of the study or that limit the progression of training, such as orthopedic, neurological and heart disease; and not signed the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-3dmsbk	Feet reflex massage in older womem	Recruiting	Intervention	2016-09-09	<NULL>	<NULL>	1122	Effects of podal reflexology massage in older womem	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Instituto Federal do Paraná - IFPR	Instituto Federal do Paraná - IFPR	https://ensaiosclinicos.gov.br/rg/RBR-3dmsbk	<NULL>	Independent older women, 60 years and over; residents in the Curitiba city and metropolitan area, Parana, Brazil; without cognitive impairment according to the Mini mental state examination	Volunteers with diagnosis of the following disease: neurological, trauma-orthopedic, cardiac, respiratory, kidney, liver, osteoporosis, decompensated diabetes, decompensated endocrine and arterial hypertension; and voluntary unavailable to participate in any stages of the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-5wddpz	Evaluation of the use of laser for treatment in children&apos;s deep caries.	Recruiting	Intervention	2016-12-29	<NULL>	<NULL>	1124	Use of antimicrobial Photodynamic Therapy as an adjunct in reducing microorganisms of the oral cavity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-21	Faculdade de Odontologia - Universidade Federal Fluminense	Faculdade de Odontologia - Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5wddpz	<NULL>	Children between 3 and 12 years of age with primary or permanent molars having active  deep caries lesion and without pulp involvement	Children whose guardians refused to sign the informed consent document; children who do not cooperate with the clinical examination; with syndromes or chronic systemic diseases; teeth with painful symptoms consistent with irreversible pulpitis or mobility; periodontal changes; roots with pathological resorption; cases of primary teeth roots in advanced stage of physiological resorption and patients who have made use of any antibiotics during the study period or within three months before its initiation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:33
RBR-2hp7rs	Evaluation of blood return and varicose veins in the lower limbs of pregnant women users and non-users of elastic stockings	Recruiting	Intervention	2016-12-29	<NULL>	<NULL>	1127	Evaluation of venous reflux and varicose veins in lower limbs of pregnant women: comparison between users and non-users of compression stockings	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-07	Universidade Estadual Paulista - Faculdade de Medicina de Botucatu	Universidade Estadual Paulista - Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-2hp7rs	<NULL>	pregnant women who are between the 10th to 15th week of gestation; over 18 years old; not suffering from arterial disease, lymphatic or orthopedic.	patients overweight or obese; patients with edema of the lower limbs caused by other reasons than venous;  with CEAP classification above 3; carrier of recent or old DVT.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-3nxn34	Reproducibility of blood pressure reduction and its physiological regulators after a sessions of  exercise executed in different days	Recruiting	Intervention	2016-12-29	<NULL>	<NULL>	1128	Reproducibility of post-exercise hypotension and its hemodynamic and autonomic mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-15	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3nxn34	<NULL>	"Both genders
Age between 20 and 60 years
Blood pressure levels below 160/105 mmHg
Absence of cardiovascular disease
No use of medications that block the autonomic nervous system
Absence of orthopedic problems that contraindicates physical exercise"	Presence of complex arrhythmias and/or ischemia during a cardiopulmonary exercise test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-6s6p7s	Use of resting net in preterm infants who are in incubators in the Intensive Care Unit	Recruiting	Intervention	2017-01-03	<NULL>	<NULL>	1131	The use of therapeutic network in incubators used by Newborns in the Neonatal Unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de Mato Grosso do Sul - UFMS	Hospital Regional de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6s6p7s	<NULL>	Newborns independent of sex; Hemodynamically stable; More than 72 hours of life; Spontaneous breathing; Without congenital malformations, without neurological disorders; Minimum weight of 700 grams.	Do not meet the criteria eligible for the study; Not complete the time required for the completion of the research; Peri-intraventricular haemorrhage grade III or IV; Use of supplemental oxygen therapy; FC less than 20 bpm than the initial measurement; Signs suggestive of increased respiratory work.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-4b7gmb	Comparison of physical fitness and the morbidly obese oxygen consumption during different cardiopulmonary test protocols on treadmill and stationary bike	Recruiting	Observational	2017-01-06	<NULL>	<NULL>	1134	Comparison of cardiopulmonary and metabolic performance and CLVO2 analysis in obese patients during cardiopulmonary stress tests on treadmill and bicycle: incremental protocol x constant load	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-03-08	Universidade Federal do Rio Grande do Norte	Selma Sousa Bruno	https://ensaiosclinicos.gov.br/rg/RBR-4b7gmb	<NULL>	The study included female subjects (since obesity waiting list is formed for the most part by women and so there is no contamination of data and bias due to low number of male patients) with: Sheet physical therapy preoperative evaluation completed; subjects with obesity class II and III, have BMI&gt; 35 and &lt;60 kg / m2); the age and / or equal to 18 and less than and / or equal to 59 years; Sedentary individuals or assets; no deficit in the locomotor system and / or balance disorders reported or detected on physical examination without changes in heart function (released by cardiologist by certified to perform physical exercise), and acceptance and signing of the informed consent and informed .	The exclusion was determined when the subjects did not properly perform the ventilatory evidence presented spirometric function not preserved by FEV1 / FVC &lt;0.70, present musculoskeletal limitations or pain preventing the holding of the test, submit a confirmed diagnosis of some heart disease and asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-8n94qg	Neurofunctional Physical Therapy in Parkinson&apos;s disease: a feasibility trial	Recruiting	Intervention	2017-01-09	<NULL>	<NULL>	1136	Neurofunctional Physical Therapy in Parkinson&apos;s disease: assessments tools and answer to physiotherapy intervention	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade do Estado de Santa Catarina	University of Miami Miller School of Medicine	https://ensaiosclinicos.gov.br/rg/RBR-8n94qg	<NULL>	Individuals diagnosed with Parkinson&apos;s disease confirmed by the neurologist according to London Brain Bank criteria (Hughes et al., 1992); 50-90 years, mild to moderate staging of disease (stages 1 to 3 according to the Hoehn and Yahr Scale); stable medication (on the same medication / dose for at least 4 weeks); cognitive level related to scholarity level (in Mini Mental State Exam).	Patients presenting other neurological disorders associated; presenting orthopedic pathologies and / or joint limitations that affect the musculoskeletal system and make it difficult and / or difficult to perform the training; individuals who can not perform walking independently.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-5q9svp	Acupuncture evaluation in treatment of pain related to articulation of the chewing region.	Recruiting	Intervention	2017-01-09	<NULL>	<NULL>	1137	The evaluation of Acupuncture effectiveness in the treatment of chronic pain associated with temporomandibular disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5q9svp	<NULL>	Agree to sign the consent form;Diagnosed with muscular TMD, joint or mixed, according to the criteria of the RDC-TMD;In the age group between 20-65 years;Both sexes;Symptomatic pain for more than six months	"With a rheumatic diseases history affecting the muscles and joints;psychiatric or neurological conditions that complicate the diagnostic process;surgical implants for treatment of TMD;
Blood coagulation disorders;Needle Phobia;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:34
RBR-2wkqpw	Hand puncture in relieving pain of the newborn during collection of the foot test	Recruiting	Intervention	2017-01-12	<NULL>	<NULL>	1148	"Venipuncture in hand to relieve newborn pain during the collection of newborn screening: a
randomized clinical trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-05-01	Universidade de Brasília	Secretaria de estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-2wkqpw	<NULL>	Newborns (&lt;28 days), of both genders, independent of gestational age admitted to the hospital unit studied.	Babies with cerebral anatomical abnormality; injury or bone fracture; Apnea history less than 72h; Venous access infiltrates or lost at the time of research; baby who were undergoing painful invasive procedures such as punctures and passing of a nasogastric tube or vesical cathetein less than 1 hour of the study intervention; involvements of the CNS as cerebral hemorrhages, syndromes with neurological impairment, seizure history and hypertension; and also the presence of congenital heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-4frygy	Patellar tendon pain: risk identification in athletes	Recruiting	Intervention	2017-01-12	<NULL>	<NULL>	1149	Patellar tendinopathy in sport: risk profile identification and preventive strategies definition.	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Financiamento próprio dos pesquisadores	Financiamento próprio dos pesquisadores	https://ensaiosclinicos.gov.br/rg/RBR-4frygy	<NULL>	Athletes within 15 to 45 years old, both sexes, no history of injuries in last year, no orthopaedic surgery history and with full partcipation in sport team routine.	No show in data collection and/or pain or incapacity during the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-36byz5	The effect of use of probiotic Lactobacillus plantarum in children and adolescents with elevated levels of cholesterol or triglycerides and with nephrotic syndrome	Recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1153	The use of probiotic L. plantarum in dyslipidemia in children and adolescents with nephrotic syndrome: a double-blind, randomized, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-20	Patrícia Marques Fortes	Hopital das Clínicas da Universidade Federal de Goiás (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-36byz5	<NULL>	"Cases and controls: individuals 2-17 years and 11 months; of both sexes in regular outpatient follow-up for at least 1 year and that have in the last three months:24h proteinuria less than 50 mg / kg / day or 40 mg / m² of body surface area (BSA)Serum Albumin &gt; 2.0 g / dl;
total cholesterol &gt; 170 mg / dl and / or triglyceride levels &gt; 130 mg / dl; preserved renal function (glomerular filtration rate &gt; 60ml / min); in corticoids (prednisone &lt; 1mg / kg / day) and / or cyclosporin 5mg / kg / day; not in use of statins,do not have infectious processes at the time of selection; have not presented clinical or laboratory decompensated SN less than 3 months."	Individuals with kidney disease from stage III; pregnant women; cancer patients; acquired immunodeficiency syndrome, hypothyroidism, metabolic disease; severe cardiovascular disease; cerebrovascular diseas; symptomatic heart failure; viral or bacterial infectious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-9sq542	Efficacy of the treatment of chronic periodontitis with antimicrobial Photodynamic therapy associated with conventional treatment in diabetic patients	Recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1156	Effectiveness of antimicrobial Photodynamic Therapy (aPDT) as adjuvant therapy in the treatment of periodontitis, in patients with type 2 diabetes melittus: clinical randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-9sq542	<NULL>	Patients aged between 30 and 70 years,both genders, diagnosis of chronic periodontitis with at least 4 places with probing depth (PS) &gt; 5 mm and insertion loss clinic (NIC) &gt; 3 mm with bleeding on probing (SS), Patients diagnosed with diabetes mellitus type 2 (HbA1c &gt; 7%), at least 15 teeth, excluding third molars.	Smokers or ex-smokers more than 12 months; patients with anemia; active cancer patient; history of antibiotic therapy in 6 months; history of anti-inflammatory therapy in the last 3 months; patients with blood disorders; pregnancy; patient in orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-4mx7jx	Effects of using Nintendo Wii® video game in patients with Parkinson&apos;s disease to study upper limb function	Recruiting	Intervention	2017-01-16	<NULL>	<NULL>	1157	Study of non-immersive virtual reality in patients with Parkinson&apos;s disease: funcional analysis in upper extremities	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-15	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Associação Fluminense de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-4mx7jx	<NULL>	Individuals must be between 60 and 70 years old of both genders.To present a diagnosis of Parkinson&apos;s disease classified in stages 2, 2,5 and 3 of the modified scale of Hoehn and Yahr , obtaining more than 13 points in the Mini-Mental State Examination (MMSE) For illiterate, 18 points for low or medium education and 26 for education above 9 years, be able to copy the pentagon and must be without physiotherapy treatment for at least 3 months prior to the training program.	Patients with other neurological and musculoskeletal conditions limiting upper limb function; Unstable heart disease or cardiorespiratory failure; Patients with cognitive limitations who fail to respond to questionnaires and obey verbal and visual commands; Resting heart rate greater than 120 bpm; Systolic blood pressure greater than 180 mmHg and diastolic blood pressure greater than 100 mmHg; Patients whose medication or dose is modified during the training protocol; Patients using a pacemaker or electronic biological device according to the manufacturer of the Nintendo Wii ™.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:35
RBR-92md93	Evaluation of Laser Therapy in the Prevention and Treatment of Oral Irritations Due to Cancer Treatment	Recruiting	Intervention	2017-01-18	<NULL>	<NULL>	1161	Evaluation of the Low Intensity Laser in the Prevention and Treatment of Oral Mucositis: Double Blind Randomized Clinical Trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-92md93	<NULL>	Group 1: Patients with head and neck neoplasms undergoing radiotherapy;Group 2: Patients with head and neck neoplasms undergoing radiochemotherapy;Group 3: Patients with neoplasias of the gastrointestinal tract under chemotherapeutic treatment (Fluorpyrimidine).	Patients younger than 18 years;Presence of oral ulcerations or erosions;Cognitive deficits;Simultaneous participation in another clinical study;In long-term treatment with photosensitizing agents.Difficulty opening the mouth, such as trismus or maxillo-mandibular block.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-7h6f6p	Anxiolytic effect of NSR meditation on emotions of university students	Recruiting	Intervention	2017-01-19	<NULL>	<NULL>	1163	Effect of NSR meditation on the anxiety levels of university students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7h6f6p	<NULL>	University students of both sexes, aged between 18 and 30 years who do not present pathological conditions that could interfere with the results, such as neurological, metabolic and psychiatric disorders; who did not use chronic medication; who did not present pre-menstrual complaints; and who had no previous experience with meditation or relaxation techniques.	Waiving by the volunteer; who present pathological conditions that could interfere with the results, such as neurological, metabolic and psychiatric disorders; who use chronic medication; who present pre-menstrual complaints; and who had previous experience with meditation or relaxation techniques.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-9zgdbb	Viscosupplementation and platelet-rich plasma in knees chondral injuries.	Recruiting	Intervention	2017-01-23	<NULL>	<NULL>	1165	Comparison between viscosupplementation and PRP in Knees chondral lesions in young patients.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Uniort.E Ortopedia Especializada	Uniort.E Ortopedia Especializada	https://ensaiosclinicos.gov.br/rg/RBR-9zgdbb	<NULL>	Chondral injury in just one knee; age between 20 and 40 years old; both genders; BMI under 30.	Presence of osteoarthritis; allergy to blood components.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-9t2jr8	Effect of an intervention on behavior change in adolescents with Excess of Weight in the Centre for Nutritional Recovery and Education (CREN) - Project I learned, I taught	Recruiting	Intervention	2017-01-24	<NULL>	<NULL>	1166	"Effectiveness of multidisciplinary intervention based on the Transtheoretical Model
Of Behavior Change for the treatment of adolescents with Excess of
Weight in the Centre for Nutritional Recovery and Education (CREN) - Project I learned,
I taught"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-22	Universidade Federal de São Paulo	Centro de Recuperação e Educação Nutricional	https://ensaiosclinicos.gov.br/rg/RBR-9t2jr8	<NULL>	Schoolchildren; aged 8 to 12 years; enrolled in the two eligible schools; enrolled in the third, fourth and fifth years of elementary education.	Schoolchildren with cognitive delays selfreported by parents and  or teachers who could limit their involvement in activities such as responding to questionnaires; That have motor limitations to participate in physical activities; that are twins; Who are using known medications that influence body weight; Who have known family problems that could affect overall compliance and participation in the Program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:36
RBR-8r3b7y	Clinical avaliation of patients with intestinal neuronal dysplasia after a long time period	Recruiting	Observational	2016-09-28	<NULL>	<NULL>	1177	Long term clinical follow up in patients with intestinal neuronal dysplasia	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2014-03-06	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho (FMB-UNESP)	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista Julio de Mesquita Filho (FMB-UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-8r3b7y	<NULL>	patients who had received histopathological diagnosis of Intestinal Neuronal Dysplasia type B; that have been diagnosed and treated for over 5 years; have agreed to participate in the study; signed informed consent term.	Refuses to participate in the study; less than 5 years after initiation of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-8bwz7r	Does the enamel surrounding carious lesions influence the success of adhesive restorations in primary molars?	Recruiting	Intervention	2017-03-06	<NULL>	<NULL>	1178	Does the use of rotary instruments in the cavo-superficial enamel influences the survival of composite resin restorations in primary teeth submitted to selective removal of carious tissue?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-07	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-8bwz7r	<NULL>	Children from 5 to 9 years old; Primary molas - ICDAS 5; Without restoration or other lesions that interfere with the lesion to be treated	Children with difficult behavior; Tooth without antagonist; Lesions involving more than one surface; Painful symptomatology; Signs of pulpal alteration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-5r5sc5	Anxiety and singing: influence of administration of a single dose of Oxytocin in men	Recruiting	Intervention	2017-03-08	<NULL>	<NULL>	1181	Anxiety and singing voice: clinical parameters and effects of acute administration of Oxytocin in men	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-10-20	Faculdade de Medicina de Riberão Preto - Universidade de São Paulo	Faculdade de Medicina de Riberão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5r5sc5	<NULL>	Male singers; Aged between 18 and 35 years; With training or experience in singing voice of at least three years; Perform at least one musical presentation in public.	Use of the following medications; Antihistamine, antidepressants, antihypertensive, hypoglycemic and anti-inflammatory; Complaint of auditory acuity; History of neurological disease, psychiatric disorders, renal, pulmonary, hepatic and / or cardiovascular problems; Abuse of alcohol, tobacco and users of illicit substances; Moderate to severe dysphonia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-83dk7z	Colostrum administration in very low birth weight preterm infants - clinical trial	Recruiting	Intervention	2017-01-25	<NULL>	<NULL>	1182	Oral immunotherapy in very low birth weight preterm infants - randomized double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Hospital Moinhos de Vento	Faculdade de Medicina da Pontífice Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-83dk7z	<NULL>	Premature inborn at Hospital Moinhos de Vento; with birth weight equal to or below 1500 grams; and/or gestational age equal to or less than 30 weeks; admitted to the NICU.	Malformations incompatible with life; malformation of the gastrointestinal tract; contraindication to breast milk; death in the first 6 days of life.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-32m5b8	Use of knee braces in sports.	Recruiting	Observational	2017-03-13	<NULL>	<NULL>	1184	Use of knee braces in sports.	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-11-07	Uniort.E Ortopedia Especializada	Uniort.E Ortopedia Especializada	https://ensaiosclinicos.gov.br/rg/RBR-32m5b8	<NULL>	both genders; above 18 yo; during exercise; wearing knee braces.	Do not agree to participate in the project.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-2gqmvf	Performance of two adhesives in restoration of cervical lesions: a clinical trial	Recruiting	Intervention	2017-03-17	<NULL>	<NULL>	1186	Performance of universal adhesive systems in different etching strategies in non-carious cervical lesions: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-13	Universidade Federal de Santa Maria - UFSM	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-2gqmvf	<NULL>	to have at least 4, 8 or 12 teeth with non-carious cervical lesions (LCNC) on the vestibular face of anterior or premolar teeth;  lesions being caries-free and non-retentive; lesions with depth greater than 1mm; in vital teeth and without mobility; to be in good health; at least 18 years old; be able to understand and sign the informed consent form; oral hygiene in an acceptable level; present at least 20 teeth in occlusion; be willing to return the reevaluation consultations.	Teeth with considerable or severe dentinal hypersensitivity; teeth without pulp vitality to the thermal test; absence of antagonistic tooth; patients in orthodontic treatment; patients with severe bruxism with wear facets corresponding to more than 50% of dental structure; extremely poor oral hygiene; with severe or chronic periodontal disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:37
RBR-7dkf7k	Genetic markers and their association with resting energy expenditure in women with severe obesity before and after bariatric surgery	Recruiting	Intervention	2017-03-27	<NULL>	<NULL>	1193	Molecular markers related to energy metabolism and its association with substrate oxidation and resting metabolic rate in women with grade III obesity pre and post bariatric surgery	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-7dkf7k	<NULL>	Women with indication for bariatric surgery using the Roux-en-Y gastric bypass technique; For the eutrophic group will be selected women with nutritional classification of eutrophy, according to the body mass index.	Will be excluded from the study of patients who present modification in the standard surgical technique, loss of follow-up with staff, pregnant women, thyroid diseases, psychiatric disorders and cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-5mr2zq	"Effect of high folic acid levels on enzymes activity and its relation with
expression of genes related to folate metabolism"	Recruiting	Intervention	2017-03-27	<NULL>	<NULL>	1194	"Effect of high folic acid levels on DHFR activity and its relation with
mRNA expression of genes related to folate metabolism and inflammatory cytokines"	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2014-11-01	CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5mr2zq	<NULL>	For the group of non-pregnant women with a history of primary miscarriage: women aged 18-40 years; at least two histories of recurrent spontaneous miscarriage; no viable fetus; in use of 5 mg of folic acid daily. For the prospective study with intervention of 5 mg of folic acid per day: healthy volunteers; both sexes, from 18 to 45 years, non smokers.	Women with a history of abortion who are pregnant during study enrollment. For the study with intervention of 5 mg of folic acid per day will be excluded chronic alcoholics; patients with chronic diseases; pregnant women; smokers; individuals who underwent major surgery to less than 6 months or donated blood in the last 3 months; and Those who have used polivitamins in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-46xj92	Effects of laser on strength and muscle fatigue	Recruiting	Intervention	2017-03-29	<NULL>	<NULL>	1198	Immediate effects of low-level laser therapy (780 nm) in muscle fatigue and metabolic performance: a randomized, crossover and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Centro Universitário Uninovafapi	Centro Universitário Uninovafapi	https://ensaiosclinicos.gov.br/rg/RBR-46xj92	<NULL>	Young men; aged between 18 and 25 years; apparently healthy; sedentary.	Individuals who presented with a musculoskeletal disease or trauma in the last three months; those who took supplements or use of medication during the period of their participation in the study; not have consumed alcohol, large amounts of tea or coffee (more than two cups), or any other caffeine-rich food 24 hours before the test; have slept at least 8 hours  the night before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-5gkhhj	The effects of beet and grape juice consumption and exercise on blood pressure and glycemia in patients with excess weight and high glycemia	Recruiting	Intervention	2017-03-30	<NULL>	<NULL>	1199	Effects of dietary nitrate supplementation and exercise on hemodynamic variables and oxidative stress in subjects with overweight and hyperglycemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-15	Ana Paula Trussardi Fayh	Departamento de Nutrição da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5gkhhj	<NULL>	Participants should be overweight or obese (Body Mass Index equal to or greater than 25 kg/m² and less than 40 kg/m²) and present hyperglycemia (glycemia equal to or greater than 100 mg/dl); non smokers; Are not physically active and are releasing your physician for exercise.	Smoking participants; Alcoholics; obese degree III (body mass index equal to or greater than 40 kg/m²); In the physical activity readiness questionnaire and in the Rose questionnaire do not show to be able to carry out the evaluations; Present cardiovascular, respiratory, neuromuscular, osteoarticular and other conditions that are not indicated or are not advisable to carry out stress tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-6yppv3	Comparison of minimally invasive techniques in the treatment of severe varices	Recruiting	Intervention	2017-04-03	<NULL>	<NULL>	1202	Comparison of efficacy and safety in the treatment of severe chronic venous insufficiency: endovenous radiofrequency ablation versus endovenous laser ablation versus foam sclerotherapy versus elastic compression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-25	Unidade de Pesquisa Clínica-Faculdade de Medicina de Botucatu - Unesp	Unidade de Pesquisa Clínica-Faculdade de Medicina de Botucatu - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-6yppv3	<NULL>	The study will include male and female patients 18 years old or older, with no limits on the maximum age,with active venous ulcers (CEAP 6),primary varicose veins documented by ultrasound,and who agreed to the terms of the studyand signed the free, prior, and informed consent (FPIC).	Patients under 18 years of age; with venous anomalies (e.g. angiodysplasia); with history of deep venous thrombosis and post-thrombotic syndrome; in use of anticoagulants; varicose veins classified as CEAP 5 or less; who had previous saphenectomy in the affected limb; without surgical or anesthetic conditions; with ulcers with signs of active infection; pregnant, postpartum or breastfeeding women; patients with history of migraine; history of interatrial or arteriovenous communication; with active cellulitis or erysipelas; abnormal laboratory liver or kidney function (creatinine clearance below 30ml/m); with signs of active skin mycosis; with previously known retinal changes; history of alcohol or drug abuse; signs of arterial insufficiencyclinically present; signs of clinically decompensated comorbidities; who do not agree with the terms of the study or refuse to sign the free and informed consent (FPIC).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-42ts9g	Study about arrangement of teeth in complete dentures of patients with resorbed edges	Recruiting	Intervention	2017-04-06	<NULL>	<NULL>	1207	Impacct of occlusal pattern  on the prognosis of conventional complete denture patients with resorbed edges	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2016-07-01	André Gustavo Paleari	Faculdade de Odontologia da Universidade Federal de Alfenas (Centro Coordenador)	https://ensaiosclinicos.gov.br/rg/RBR-42ts9g	<NULL>	Healthy volunteers; both genders; age between 50 and 70 years; total edentulism of mandible and maxilla for at least one year; bone height less than 25 mm and 16 mm in the mandibular symphysis region and mental foramen, respectively.	Volunteers with a history of alcohol or drug abuse; temporomandibular disorders; maxillary or mandibular hyperplasias or exostoses; Diagnoses of uncontrolled cardiac or psychiatric conditions; unable to attend the return visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-535hcn	Evaluation of the Efficacy of a Cognitive-Behavioral Therapy in the Management of Stress, Burnout and Sleep Disorders	Recruiting	Intervention	2017-04-06	<NULL>	<NULL>	1208	Efficacy of Biofeedback in Stress Management, Burnout, and Sleep Disorders in Nursing Academics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-13	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-535hcn	<NULL>	Nursing students from the first to fourth year; Healthy; Of both genders; With age equal to or greater than 18 years.	Students with a diagnosis of coronary artery disease, heart failure, arrhythmia, renal disease, systemic arterial hypertension, hypoglycemia, hypothyroidism; Psychiatric diagnosis by a psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders - IV (DSM-IV); Make use of heart pacemaker; Make use of beta-blocker medicine; Removal due to compulsory curricular traineeship, suspension, maternity leave or illness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-3mbdx6	Led treatment for burn healing	Recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1209	Low intensity led therapy (658nm) for burn healing: a non-randomized, double-blind and controlled clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-10	Universidade Estadual do Piauí	Centro Universitário Uninovafapi	https://ensaiosclinicos.gov.br/rg/RBR-3mbdx6	<NULL>	They nedd to have a seconddegree burn in the region of the arm, forearm, thorax or lower limbs; age between 18 and 60 years;to be in the hospital for second  degree burn treatment in the Burn Therapy Unit; to be hemodynamically stable according to  blood pressure, diuresis, heart rate and respiratory rate, axillary temperature and transcutaneous oxygen saturation.	Patient with blood dyscrasia with predisposition to hemorrhage; presence of gangrene, renal failure, pregnancy or photosensitivity; bacterial infection at the burn site; patient with hypotension, tachycardia, tachypnea, oliguria or cyanosis; patients with comorbidities that may interfere with the healing process, such as: diabetes mellitus, malnutrition, obesity and smoking; patients who use illicit drugs or medications that interfere with the healing process of wounds, such as: chemotherapy and antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:38
RBR-993bxy	Safety and whitening effectiveness evaluation of the combined use of the whitening strip iStrip and the photo activator equipment iDental Whitening for the use of the whitening strip iStrip alone	Recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1211	EN17-0067-01 - Comparative randomized clinical study for safety evaluation of the use and whitening effectiveness of the product iStrip – Dental whitening for the combined use of the product iStrip - Dental whitening and the photo activator equipment iDental Whitening	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-03-13	Basal Comércio, Importação e Exportação Ltda	Basal Comércio, Importação e Exportação Ltda	https://ensaiosclinicos.gov.br/rg/RBR-993bxy	<NULL>	"Both male and female volunteers between 25 and 55 years old;
Volunteers with dental indication for homemade teeth whitening;
Intact buccal mucosa;
Patient&apos;s agreement to follow the procedures of the study and be in the clinic on specific days and times;
Reading, understanding, agreeing and signing of the patient on the Free and Informed Consent Term"	"Pregnancy;
Lactation;
Volunteers suffering from very sensitiveteeth with exposed cervical areas may limit the treatment or make it unfeasible;
People with teeth severely stained by tetracycline grade III;
People with teeth featuring enamel hypoplasia and white areas;
Volunteers who fail to quit smoking during treatment;
Volunteers with canker sores or mouth sores;
Volunteers submitted to oral surgery in the last 03 months;
People with teeth widely restored featuring surface shape, contour and/or texture changed;
People with multiple erosion/abrasioninjuries;
Volunteers with sensitivity in the cervical region of teeth;
Active cancer or history of cancer in areas where the treatment will be carried out;
History of collagen disorder, including keloid formation or history of poor wound healing;
Any blood clotting disorder;
History of immunosuppressive diseases (including HIV infection);
Use of photosensitizing drugs;
Patients with diabetes;
Other conditions considered by the investigator as reasonable to disqualify the participation of the individual in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-76pm35	Analysis by endoscopy in patients with cirrhosis of the liver and varicose veins in the esophagus that are treating osteoporosis with risedronate medicine	Recruiting	Intervention	2017-04-10	<NULL>	<NULL>	1212	Endoscopic analysis of cirrhotic patients with esophageal varices in treating osteoporosis with risedronate	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2013-12-19	Fundação de amparo a pesquisa do estado de São Paulo- FAPESP	Faculdade de Medicina de Botucatu - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-76pm35	<NULL>	Volunteers with hepatic cirrhosis, esophageal varices and osteoporosis or osteopenia; age greater than 18 years; physical and mental conditions of ingesting medications; agreement to sign the informed consent form.	Severe psychiatric illness; upper gastrointestinal bleeding in the last 6 months; esophageal varices of large caliber; renal insufficiency; active peptic ulcer; esophageal stricture; achalasia; gastroparesis; current use of anti-inflammatories, anticoagulants, platelet anti-aggregants and alcoholic beverage; gestation or lactation; neoplasms of the esophagus, stomach or duodenum; hypersensitivity to bisphosphonates; absolute contraindication to endoscopy; advanced cirrhosis; advanced hepatic encephalopathy; previous liver transplantation; use of hormone replacement therapy; primary hyperparathyroidism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-33grwq	Therapy to dysphagia in individuals after Stroke	Recruiting	Intervention	2017-04-19	<NULL>	<NULL>	1217	Program of rehabilitation with therapeutic efficacy control in oropharyngeal dysphagia after Stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-10	Faculdade Filosofia e Ciências de Marília	Faculdade Filosofia e Ciências de Marília	https://ensaiosclinicos.gov.br/rg/RBR-33grwq	<NULL>	Individuals after stroke; oropharyngeal dysphagia, both genres.	Individuals with cognitive imparment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-7tvv57	The effect of weight loss on the quality of life and balance of obese patients who underwent stomach reduction surgery	Recruiting	Observational	2017-05-02	<NULL>	<NULL>	1219	Influence of weight loss on the mobility, balance and body perception in obese patients submitted to bariatric surgery	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-10-06	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7tvv57	<NULL>	"Group 1 (n = 15): volunteers with grade II obesity (body mass index (BMI) between 35 and 39.9 kg / m²) associated with comorbidities or degree III obesity (BMI ? 40 kg / m²) with or without Comorbid conditions, referred to bariatric gastric bypass surgery (Roux-en-Y gastric bypass gastroplasty).
Group 2 (n = 15): eutrophic volunteers, BMI between 18.5 and 24.9 kg / m²."	Muscle skeletal deformities or dysfunctions that interfere with balance; Neurological dysfunctions; Vestibular problems; Problems with uncorrectable vision with glasses or contact lenses; Use of orthoses for ambulation; Participate in a physical activity program in the last 6 months; Pregnancy; Cognitive problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-785wvb	Evaluation of the Number of Fragments of Parathyroid Gland Tissue that are Used in Patients Who Have Been Submitted to Total Removal of the Parathyroid Glands in the Treatment of Hyperparathyroidism Due to the Loss of the Renal Function.	Recruiting	Intervention	2017-05-03	<NULL>	<NULL>	1222	Total parathyroidectomy with autotransplantation for secondary hyperparathyroidism: Analysis of the number of parathyroid fragments used in the autograft	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-785wvb	<NULL>	"Patients with end-stage renal kidney disease on hemodialysis; hypercalcemia or hyperphosphatemia;
pruritus; bone pain , bone deformity or fracture, extra-osseus calcification, between 18 and 60 years"	Patients subjected to renal transplantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-64bhs5	Cardiovascular effects in subjects with pre-hypertension during maximal repetition test	Recruiting	Intervention	2017-05-06	<NULL>	<NULL>	1225	Analysis of systolic blood pressure and autonomic modulation of heart rate in subjects with pre-hypertension during maximal repetition test	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-64bhs5	<NULL>	Adult volunteers; male gender; normotensive or pre-hypertensive according VI SBH Guidelines (2013); without musculoskeletal diseases; do not practice physical exercise within previous 24 hours before the analyzes.	Attendant of private human groups, as indigenous and others; to be anti-hypertensive pharmacological treatment user; to be carrier of musculoskeletal disorders in lower limbs; to be user of alcohol, tobacco, or cofee, as well as non-practitioner of physical activity during last 24 hours before the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-9sqr6b	The simulation in the teaching of immunization in nursing graduation	Recruiting	Intervention	2017-05-09	<NULL>	<NULL>	1227	Efficacy of realistic simulation in adult immunization teaching in the context of nursing graduation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-07	Universidade Federal do Rio Grande do Norte - UFRN	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9sqr6b	<NULL>	"Nursing undergraduate students enrolled in curricular components will be included.
Primary Health Care; Have at least 75% attendance during the course offered."	Students who have a frequency of less than 75% in the course offered will be excluded; Those who are not present in the other moments of intervention and application of the research instruments; Fellows and collaborators who contributed to the execution of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-2dpc6b	Nursing interventions in decompensated Heart Failure patients	Recruiting	Intervention	2017-05-11	<NULL>	<NULL>	1228	Effect of an advanced nursing program in descompensated Heart Failure inpatients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Programa de Pós-Graduação em Ciências Cardiovasculares - Universidade Federal Fluminense	Clínica de Insuficiência Cardíaca Coração Valente	https://ensaiosclinicos.gov.br/rg/RBR-2dpc6b	<NULL>	Patients of both genders, age from 18 years; Signing of the informed consent form (TCLE); Hospitalized patients with medical diagnosis of decompensated HF independent of etiology.	Patients with cognitive neurological impairment and / or who are already participating in other studies with educational interventions will be considered.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:39
RBR-7fnbz7	Effects of exercise training on cardiovascular risk factors in HIV patients	Recruiting	Intervention	2017-05-12	<NULL>	<NULL>	1231	Prevalence and effects of aerobic training on cardiovascular risk factors in HIV patients taking antiretrovirals from the metropolitan region of Porto Alegre	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-01-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7fnbz7	<NULL>	HIV+ subjects on a stable HAART regimen for at least 3 months before enrollment; he viral load should be less than 50 copies/mL blood and they should not practice any exercise regularly for, at least, six months before to start the training protocol.	Subjects with a previous history of neurological disease; antioxidant supplements, tobacco and/or drug use, physical and/or mental disability and pregnant women were excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-83cwmx	Development of throw in healthy children	Recruiting	Observational	2017-05-15	<NULL>	<NULL>	1233	Development throw in typical children between 5 and 13 years	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-83cwmx	<NULL>	Participants included in the study: no dysfunction has history in the shoulder complex and present shoulder elevation range of motion of at least 150.	Will not be included in the study: participants with a history of rotator cuff surgery, fractures of the clavicle, scapula and humerus, systemic diseases involving the joints, cognitive deficits that prevent understanding commands to carry out the proposed task and injury that primarily affects the plexus brachial or central nervous system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-2b7kss	Effect of myofascial release in persons with Parkinson&apos;s Disease	Recruiting	Intervention	2017-05-19	<NULL>	<NULL>	1239	Acute effects of myofascial release on cardiorespiratory variables in persons with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2b7kss	<NULL>	Volunteers with clinical diagnosis of Parkinson&apos;s disease; both genders;with scores between 1 and 3 on the Hoehn and Yhar scale.	Volunteers with signs of dementia; cardiorespiratory diseases; neuromuscular diseases; musculoskeletal diseases not related to Parkinson&apos;s disease; to have made changes in the class and/or drug dose between the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-5bv8rd	Effect of light therapy (laser) in patients with respiratory disease	Recruiting	Intervention	2017-05-22	<NULL>	<NULL>	1242	Acute effects of photobiomodulation on respiratory variables and functional capacity in individuals with chronic obstructive pulmonary disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-30	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-5bv8rd	<NULL>	Volunteers over 18 years of age; diagnosis of COPD with moderate to severe classification; clinically stable; who present symptoms of dyspnea due to small and medium effort.	Alcoholics; volunteers with cardiac pacemaker implantation; neurological disease; acute exacerbations of the disease requiring hospital admission or systemic corticosteroids in the 4 weeks prior to the study; regular exercise (more than 3 times a week) in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-3wkvcy	The effect of balance training in children´s gait with involvement of one side of the body	Recruiting	Intervention	2017-05-31	<NULL>	<NULL>	1246	The effect of balance training in children´s gait with spastic hemiplegic cerebral palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-06-06	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3wkvcy	<NULL>	Children with cerebral palsy; age between 5 and 15 years; GMFCS 1 or 2; independent walking; sign the TCLE	Bone deformity in lower limbs; use crutches or walkers; surgery for less than a year; do not sign the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-6f497w	Laserterapy and antimicrobial photodinamic therapy on oral mucositis of children: a clinical trial	Recruiting	Intervention	2017-05-31	<NULL>	<NULL>	1247	Randomised clinical trial of antimicrobial photodinamic therapy (aPDT) and low level laser therapy (LLLT) on oral mucositis of pediatric patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-11	Universidade Federal de Pernambuco	Instituto de Medicina Integral Prof. Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-6f497w	<NULL>	Patients from zero to twenty-one years, both genders, diagnosed with malignancies undergoing quimiotherapy;Pediatric patients diagnosed with OM &gt; 1 (WHO);Patients in accordance with the research by signing the informed consent.	Patients  with malignancies in oral cavity; Patients incapable of complying with the treatment; Patients in a serious situation that prevents participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-69qk5p	Evaluation of the effectiveness of the use of rifampicin to prevent leprosy in contacts of patients with multibacillary form	Recruiting	Intervention	2017-06-01	<NULL>	<NULL>	1249	Chemoprophylaxis of leprosy with rifampicin in contacts of patients with multibacillary form: a randomized, double-blind, placebo controlled study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2015-07-01	Instituto Oswaldo Cruz - Laboratório de Hanseníase	Escola Nacional de Saúde Pública Sérgio Arouca	https://ensaiosclinicos.gov.br/rg/RBR-69qk5p	<NULL>	Contacts of patients with multibacillary leprosy who agreed to undergo chemoprophylaxis; age from 6 months to 70 years; willingness to undergo clinical and anti-PGL-1 evaluation; availability for follow-up; return for vaccination in two months and for clinic evaluation in 12 months.	Clinical or laboratory confirmation of leprosy at baseline; BCG vaccination in the preceding 12 months, except for infants between 6 and 12 months of age; contacts with immunosuppression or history of tuberculosis in all its forms; pregnancy at any stage, or refusal to undergo urine pregnancy test and refusal to sign the  informed consent form (ICF).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:40
RBR-7tysgs	Protocol for the treatment of Urinary Incontinence in women with overweight and obesity through physical therapy and nutritional education	Recruiting	Intervention	2017-06-22	<NULL>	<NULL>	1264	Protocol for the treatment of Urinary Incontinence in women with overweight and obesity through cinesiotherapy and nutritional education	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Hospital Universitário Onofre Lopes	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7tysgs	<NULL>	between the ages of 20 and 65; BMI between 25 and 40 kg/m2; do not have intact hymen; do not perform exercises for the musculature of the pelvic floor; who have signed the Free and Informed Consent Form (TCLE); has not undergone urogynecologic and bariatric surgeries; do not have prolapse of level III or IV; and exhibiting symptoms of urinary incontinence (UI).	(who are unable to understand simple verbal commands or do not follow the guidance provided during the assessment; they that can not contract the PFMs alone, that is, they associate the contraction of the PFM with the accessory muscles: glutes, hip adductors and abdominals, in a visible or palpable way; with presence of vaginal or urinary infection; complain of pain during the evaluation; with more than 20% absences in the intervention period; and decide not to continue the search and / or withdraw their consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-65262c	Brief intervention for women who use alcohol	Recruiting	Intervention	2017-06-23	<NULL>	<NULL>	1266	Brief intervention for hazardous and harmful women´s alcohol consumption	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Escola de Enfermagem da Universidade de São Paulo	Secretaria Municipal da Saúde de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-65262c	<NULL>	Be female; Over 18 years old; Present risk or harmful alcohol consumption patterns; With the availability of attending the service during the necessary period	Visible behavioral changes; Signs of intoxication by psychoactive substances; Not having the Portuguese as their first language; Not have access to a landline or cell phone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-9qjr6c	Speech-language Pathology Actions at School	Recruiting	Intervention	2017-06-26	<NULL>	<NULL>	1268	Speech-language pathology actions at school: Phonological awareness, reading and writing skills training in the elementary school	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade de São Paulo - USP	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9qjr6c	<NULL>	Students in the first fundamental year; Enrolled in municipal school; Both genders; 5 to 7 years of age.	"Those who did not sign the consent form;
children with visual or hearing disabilities; physical disability; cognitive impairment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-99qqhf	Assessment and rehabilitation of patients with knee pain	Recruiting	Intervention	2017-06-29	<NULL>	<NULL>	1272	Assessment of Patelofemoral Pain Syndrome patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-99qqhf	<NULL>	Pain at least for a month. No relation with accident. Insidious onset. Positive tests for patellofemoral pain. Female. Between 18 and 30 years old.	Specific diseases of the knee. Knee surgery. Knee treatments or physiotherapy during the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:41
RBR-3ht499	Effect of heparin to prevent obstruction of the Hickman® catheter	Recruiting	Intervention	2017-07-03	<NULL>	<NULL>	1274	Effectiveness of heparin solution in preventing Hickman® catheter occlusion: clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-22	Hospital de Clínicas Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3ht499	<NULL>	Being hospitalized in the research unit; Have indication of implantation of Hickman® semi-implantable central venous catheter; Insertion of the Hickman® semi-implantable central venous catheter into the research unit or use of the first Hickman® semi-implantable central venous catheter in the research unit; First hospitalization for transplantation of stem cells in the bone marrow transplantation service in the complex of clinics of the Federal University of Paraná.	Being on anticoagulant by any route of administration; Being in fibrinolytic therapy; Present a history of allergy to heparin components; Bleeding during the period of data collection; Be refractory to platelet transfusion; Have had previous hospitalization in the research unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-7kkd97	Supplementation effect of the milk protein in  women&apos;s health bone  in postmenopausal in a lifestyle modification program with exercise.	Recruiting	Intervention	2017-07-03	<NULL>	<NULL>	1275	Supplementation Effect of Whey Protein in Bone Health Women in Postmenopausal in Modification Program Lifestyle with Exercises Physical and Food Adequacy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-02-22	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-7kkd97	<NULL>	Women; age less than 45; Amenorrhea greater than twelve months; bone densitometry in the last twelve months; bone above (higher) than - 2.4 SD; Availability participate in physical exercise programs of study.	Low bone mass by densitometry below than 2.5 SD negative; serious and neurological disorders; osteo-articular; uncontrolled metabolic; renal failure or creatinine above  1.5 mg by dL and musculoskeletal disease that impede the realization of physical exercise; Use of drugs that interfere with bone metabolism (estrogen, testosterone, bisphosphonates, raloxifene, calcitonin, fluorida, corticosteroids and calcium) antireabsortivo and anticonvulsants; History of malignancy; bone fracture occurred in the last six month.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-47tvky	Effects of metformin on brown fat of patientes with Polycystic Ovary Syndrome	Recruiting	Intervention	2017-07-04	<NULL>	<NULL>	1276	Effects of metformin on levels irisin and distribution of brown fat in women with Polycystic Ovary Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-11-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-47tvky	<NULL>	Premenopausal women diagnosed with polycystic ovary syndrome using the Rotterdam criteria (2003)	Use of antiandrogen medication in the last six months or hormones, including hormonal contraceptives, or metformin in the last two months. Obesity grade II or higher, defined as body mass index greater than 35 kg / m2. Pregnancy, postpartum and lactation. Diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-8tbhyr	Effect of Treadmill Training on Treadmill and Video Game on the Balance and Walking of People with Parkinson&apos;s Disease	Recruiting	Intervention	2016-10-10	<NULL>	<NULL>	1277	Effect of gait training and virtual reality on balance and gait in individuals with Parkinson’s disease: Protocol for a randomized, controlled, blind, clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-01	Universidade Nove de Julho	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-8tbhyr	<NULL>	Diagnosis of idiopathic PD in phase 1, 2 or 3 on the Hoehn and Yahr scale; Score ? 46 on Berg Balance Scale – BBS; Adequate vision (with or without glasses);  Adequate hearing (with or without a hearing aid).	Physical disability; Severe heart disease; History of seizure; Uncontrolled hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-86yn4b	Effects of telephone use to promote the health of people living with HIV/AIDS	Recruiting	Intervention	2017-07-10	<NULL>	<NULL>	1284	Effects of a telephone follow-up program to promote the health of people living with HIV/aids	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-07-15	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-86yn4b	<NULL>	Adults being treated for HIV; Both genders;age between 18 and 59 years.	Diminished visual acuity; dysarthria; accused; Mental disorder.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-9mmhnw	Effects of different Post-Effort Methods on Muscle Strength and Heart Rate Variability in diverse Sports Practitioners	Recruiting	Intervention	2017-07-10	<NULL>	<NULL>	1285	Influence of different therapeutic interventions of Post-Exercise Recovery on Muscle Performance and Cardiac Autonomic Modulation in practitioners of different Sports Modalities	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9mmhnw	<NULL>	Adult volunteers; practitioners of judo, handball, basketball, volleyball or indoor soccer.	Volunteers having presented sport practice history lower than one year; presence of sport injuries; physical treatment with medicines having affected the cardiac autonomic activity; presence of inflammatory processes, infections, metabolic or cardiorespiratory diseases; presence of Raynaud Syndrome or cold allergy; practice of exercise within last 24 hours previous to the investigation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-3rjby9	Gum treatment associated with application of simvastatin gel in patients with high levels os cholesterol	Recruiting	Intervention	2017-07-12	<NULL>	<NULL>	1289	Effect of non-surgical periodontal treatment associated with 1.2% simvastatin locally delivered in patients with chronic periodontitis and hyperlipidemia	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2017-06-15	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3rjby9	<NULL>	Man and women between 30 to 60 years of age; Availability to participate in all study phases; Good general health; At least 10 natural teeth, except for the third molars; Diagnosis of severe periodontitis according to Eke et al. (2012), which is at least one interproximal site with probing depth &gt;5mm and clinical attachment loss &gt;6mm in at least two interproximal sites and in different teeth; At baseline, report the use of any statin for at least 3 months;	Presence of orthodontic bands any type of fixed orthodontic appliance; Tumor (s) of soft or hard tissues of the oral cavity; Use of antibiotics 3 months prior to study begging; Pregnant or lactating women; Diagnosis or treatment for diabetes and renal chronic diseases, or any history of stroke; Need to use antimicrobial chemoprophylaxis to receive dental treatment; Had received periodontal treatment in the last 6 months; Current smokers or former smokers in less than 2 years; Body mass index &gt;30 kg/m2.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:42
RBR-3r6pc2	Cognitive stimulation therapy for elderly with cognitive and functional complaints: Brazilian adaptation and validation	Recruiting	Intervention	2017-07-17	<NULL>	<NULL>	1294	Cognitive stimulation therapy for Dementia: Brazilian adaptation and validation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Pontifícia Universidade Católica do Rio de Janeiro	Pontifícia Universidade Católica do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3r6pc2	<NULL>	Age over 60 years; Both genders; People diagnosed with dementia; Score between 10 and 24 on the Mini Mental State Exam; Be able to answer neuropsychological evaluation.	Age greater than 95 years. Mental retardation previously diagnosed according to ICD criteria 10.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-3sst2s	Electrical stimulation in cirrhotic in peripheral muscle strength and exercise capacity	Recruiting	Intervention	2017-07-18	<NULL>	<NULL>	1296	Neuromuscular electrical stimulation in cirrhotic in peripheral muscle strength and exercise capacity: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-20	Fundação Universidade do Estado de Santa Catarina	Fundação Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3sst2s	<NULL>	Diagnosis Liver cirrhosis, Child-Pugh B and C;  stable and under medical supervision ; patients without : uncontrolled hypertension, recent ischemic heart disease ( 3 months or less ) , unstable angina and severe cardiac arrhythmias ; no evidence of gastrointestinal bleeding , encephalopathy , acute pancreatitis or spontaneous bacterial peritonitis ; patients with absence of respiratory diseases , orthopedic diseases and limiting neurological diseases for electrostimulation and protocol ; patients who do not undertake any form of physical training or who have been held for more than 6 months .	Failure to perform any of the study assessments ( lack of understanding or cooperation ) ; deterioration of the clinical picture during the search ; clinical complications of cardiorespiratory nature and / or musculoskeletal during the survey period;  patients with Hepatopulmonary syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-4z4f48	Effects of Kinect Adventures games compared to conventional physical therapy in postural control of the elderly: a randomized clinical trial	Recruiting	Intervention	2016-04-12	<NULL>	<NULL>	1297	Effects of Kinect Adventures games compared to conventional physical therapy in postural control of the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Faculdade de Medicina da Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-4z4f48	<NULL>	Seniors will be selected aged 60-80 years; of both genders; which did not show neurological and orthopedic disorders that promote disability of the elderly remain in bipedalism and wade unaided or cardiovascular disease uncompensated such as: angina; heart failure; high blood pressure decompensated; show no signs of cognitive impairment; the normal or corrected visual acuity measured by Snellen chart; normal or corrected hearing is clinically assessed by the whisper of the test; who did not have previous experience with the Kinect system and accepting to participate by signing the Informed Consent and Informed.	The elderly will be excluded that during the study period submit any clinical change that makes it impossible to perform physical exercises in standing position as: cardiorespiratory; orthopedic or neurological disorders; seniors who are missing for more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-2hpkp3	Effect of vaginal contraction exercise in bladder control in women with multiple sclerosis and neurological disease caused by the virus HTLV1	Recruiting	Intervention	2017-07-19	<NULL>	<NULL>	1298	Pelvic floor training in the treatment of lower urinary tract symptoms in women with Multiple Sclerosis (MS) and HLTV-I associated Myelopathy (HAM / TSP): A randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-10	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2hpkp3	<NULL>	"Women with diagnosis defined in Multiple Sclerosis, in the relapsing remitting form
And with the disease stabilized for at least four months, EDSS score less than or equal to 6.5. Or women with a diagnosis defined in HAM / TSP, with more than 18 years of age with HTLV - 1 positive ELISA and confirmed by Western blot (HTLV Blot 2.4), with urological and neurological evaluation, Osame Motor Scale dysfunction OMSS) and score in the lower EDSS equal to 6.5.
Aged over 18years, cognitive ability to respond to evaluation questionnaires and treatment protocol, presenting symptoms of urinary dysfunction for at least six months (at least three of the following: urgency,
Urge incontinence, high voiding frequency, nocturia and nocturnal enuresis), with no history of previous treatment with pelvic floor exercises, those that will not present genital prolapses
Or history of previous gynecological surgeries that are not pregnant, with no history of vaginal delivery or cesarean section within a period of less than six months prior to the start of the study, as well as those who will be out of menopause and without urinary infection excluded by laboratory examination."	Pregnant women with Diabetes mellitus, indigenous ethnicity and or quilombola, under the age of 18. Women who present exacerbation of symptoms or outbreak during the course of treatment, those who can not attend the treatment and refuse to perform the proposed treatment or voluntarily give up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-5mgv4k	Treatment of Temporomandibular Joint Problems with Laser Therapy and Occlusal Splint	Recruiting	Intervention	2017-07-20	<NULL>	<NULL>	1302	Treatment of Temporomandibular Disorder with Laser Therapy and Occlusal Splint: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5mgv4k	<NULL>	Patients diagnosed with temporomandibular disorder; myofascial pain by the Research Diagnostic Criteria (RDC)	Pregnancy; clinical conditions of muscle spasm; myositis; contracture; polyarthritis; acute traumatic injuries; disc displacement without reduction; total or partial edentulous patients that include the anterior region; treatment with another health professional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-299d6k	Exercise effect on human intestinal bacteria	Recruiting	Intervention	2017-07-23	<NULL>	<NULL>	1303	Exercise effect on human gut microbiota: an exploratory study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-24	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-299d6k	<NULL>	Young adults (18 and 35 years old); sedentary for at least six months; BMI between 18.5 and 29.9kg/m²	Those who ingested any antibiotics in the last three months; if they are vegan vegetarians or are following some kind of restrictive diet; if they have intolerance or allergy to any food; presence of chronic or acute diseases of the gastrointestinal tract and/or other chronic disease, such as dibetes or arterial hypertension; presenting disability and/or any other clinical complications that prevent the practice of physical exercise. Besides that, the lack of availability to participate in our training schedule and collections.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-27p6qf	Pilates effect on sexuality, self-esteem and the quality of life of women who had Breast Cancer and survived	Recruiting	Intervention	2017-07-24	<NULL>	<NULL>	1306	Effect of Pilates exercise method  in sexuality, self-esteem and quality of life of women survivors of Breast Cancer: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-29	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-27p6qf	<NULL>	Female volunteers; Age between 35 and 65 years, non-smokers; survivors of the treatment of malignant neoplasm of the breast.	Volunteers with neurological comorbidities; Limiting deficiency; Cancer recurrence or metastasis; Latex allergy; That are not available to participate in all stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-73tqdf	Study of infection zika virus in pregnancy and infants	Recruiting	Observational	2017-07-26	<NULL>	<NULL>	1307	International prospective observational cohort study of zika in infants and pregnancy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Fundação Oswaldo Cruz	National Institutes of Health	https://ensaiosclinicos.gov.br/rg/RBR-73tqdf	<NULL>	"PREGNANCY
Consent;
Older than 15 years;
Authorization and consent provided by local law;
Pregnancy confirm by measuring beta hCG blood / urine or through fetal heartbeat on ultrasound exam;
Proof that the participant is in first trimester of pregnancy (between 4 and 12 weeks) by gestational calculator or fetal ultrasound; 

NEWBORN
All children born to women enrolled in the observational cohort are eligible for the study"	"PREGNANCY
Women who can´t join the proposed protocol program;
Pregnant women enrolled in other studies , including other research ZIKV;

NEWBORN
If the legal representant of the child doesn´t consent to the child to participate to the study;
Babies born to mothers who aren´t partipate of the ZIP cohort study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-6bjfd5	Effects of Electrical Stimulation and leg Movement with Stationary Cycling in ICU and infirmary patients	Recruiting	Intervention	2017-07-26	<NULL>	<NULL>	1308	Effects of Electrostimulation associated with Active Movement of the lower limbs with Cycloergometro in patients admitted to the intensive care unit and infirmary of the Santa Casa de Alfenas	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-12-08	Universidade Federal de Alfenas - UNIFAL MG	Universidade Federal de Alfenas - UNIFAL MG	https://ensaiosclinicos.gov.br/rg/RBR-6bjfd5	<NULL>	Patients with hospitalization period of at least two days; age between 18 and 50 years; both sexes, sensitivity and cognitive preserved; Glasgow Coma Scale 15; hemodynamically stable; adequate pulmonary gas exchange; Inspired fraction of oxygen less than or equal to 60% and positive pressure at the end of the expiration less than or equal to 10 cmH2O with peripheral oxygen saturation greater than 88%; Sign the Free and Informed Consent Form.	Pregnant patients; change in sensitivity; cognitive alteration; shocks; renal support; thrombocytopenia; deep vein thrombosis; agitation and confusion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:43
RBR-6d9657	Comparison of the results of two different types of acids on the face of women with oily and blemished skin.	Recruiting	Intervention	2017-07-28	<NULL>	<NULL>	1311	Comparison of effectiveness of chemical peeling of retinoic acid and mandellic acid on oleosity and acne hypercromy in adult women: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-25	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6d9657	<NULL>	Will be included female individuals, aged between 18 years and 48 years, with a phototype of I to IV and with complaint of hyperchromia after acne on the face verified by Baumman questionnaire	Pregnant and lactating women will be excluded who have is subjected to dermatological and / or cosmetic treatment in the face in the last 6 months, or who have active infection in the face (acne&gt; grade I), disease dermatological or metabolic causing hyperpigmentation of the face, such as Syndrome Cushing&apos;s and Lupus Systemic Eritrematoso or hyperpigmentation from birth as nevus. Similarly, those who miss session 01 any of the groups are excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-4xr92k	Effectiveness of Magnesium Sulphate for General Anesthesia in Adults	Recruiting	Intervention	2017-08-02	<NULL>	<NULL>	1314	Effectiveness of magnesium sulphate compared to rocuronium for rapid sequence orotracheal intubation in adult patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-07-01	Centro Universitário Tiradentes	Centro Universitário Tiradentes	https://ensaiosclinicos.gov.br/rg/RBR-4xr92k	<NULL>	Patient diagnosed with acute appendicitis; Physical status ASA I and II; Age between 18 and 70 years.	Pregnancy; Neuromuscular disease; renal insufficiency; Body mass index greater than 30 km.m-2; Anticipation of difficulty in handling the airway; Chronic use of calcium channel blockers; Chronic use of medicines containing magnesium; Past allergy to magnesium sulfate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-3ndqws	Effect of a caries paralyzing substance on deep cavities of milk molars compared to a caries obturator treatment	Recruiting	Intervention	2017-08-02	<NULL>	<NULL>	1316	Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3ndqws	<NULL>	Children aged 2 to 5 years;who are in good general health;who have at least one active dentin carious lesion on the occlusal surface of primary molars corresponding to ICDAS codes 5 or 6.	Children with systemic or neurological diseases;whose families intend to move from Rio de Janeiro next year;with a history of allergy to silver or any substance present in the different materials to be used for treatment. Besides that, teeth with spontaneous or provoked pain, dental mobility or radiographic signs of involvement or possible pulp involvement;shows possible pulp involvement by radiographic examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-4752vs	Evaluation of desensitizing protocols in reduction of teeth hypersensitivity level	Recruiting	Intervention	2017-08-07	<NULL>	<NULL>	1317	Evaluation of desensitizing protocols in reduction of dentin hypersensitivity level - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia - FOUFU	Hospital Odontológico da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4752vs	<NULL>	Healthy individuals of both sexes who are interested in the treatment of Dentin Hypersensitivity; Agree to participate and sign the informed consent form (TCLE); Patients with all teeth in their mouth; Patients with at least three teeth with Dentin Hypersensitivity in different quadrants.	Presence of dentin hypersensitivity caused due to the presence of caries or unsatisfactory restorations; Patients in orthodontic or periodontal treatment; Patients performing dental whitening; Presence of spontaneous  pain in the tooth with dentin hypersensitivity, characterizing pulpitis; Presence of periodontal disease; Unsatisfactory oral hygiene; Use of extensive prostheses; Patients with severe bruxism and loss of vertical dimension; Patients with uncontrolled gastroesophageal reflux disease; Patients with uncontrolled systemic and / or psychological diseases; Pregnancy and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-3pr9pp	Evaluation of different potassium oxalate concentrations in teeth hypersensitivity	Recruiting	Intervention	2017-08-07	<NULL>	<NULL>	1318	Clinical evaluation of different potassium oxalate concentrations in dentin hypersensitivity treatment	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-16	Hospital Odontológico da Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3pr9pp	<NULL>	The criteria for inclusion of the patients will be: healthy individuals who are interested in the treatment of Dentin Hypersensitivity; Agree to participate and sign the informed consent form (TCLE); Patients with all teeth in their mouth; Patients with at least two teeth with Dentin Hypersensitivity in different quadrants.	The criteria for exclusion of patients will be: presence of dentin hypersensitivity caused due to the presence of caries or unsatisfactory restorations; Patients in orthodontic or periodontal treatment; Patients performing dental whitening; Presence of spontaneous  pain in the tooth with dentin hypersensitivity, characterizing pulpitis; Presence of periodontal disease; Unsatisfactory oral hygiene; Use of extensive prostheses; Patients with severe bruxism and loss of vertical dimension; Patients with uncontrolled gastroesophageal reflux disease; Patients with uncontrolled systemic and / or psychological diseases; Pregnancy and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-5mvff4	Electromyography of cough in subjects with Spinal Cord Injury	Recruiting	Observational	2017-08-01	<NULL>	<NULL>	1321	Mapping of the Surface Electromyographic Signal in the pectoralis major muscle during the cough in subjects without and with Spinal Cord Injury	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-08-10	Faculdade de Medicina da Universidade de Brasília	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-5mvff4	<NULL>	Group of spinal cord injury (LM): Individuals with traumatic spinal cord injury with motor level of injury between C8 and T11; Minimum age of 18 years; Hemodynamically stable; And that they agree to participate in the research and sign the Free and Informed Consent Form. Control group (CG): Healthy individuals; No history of chronic and / or active disease; Individuals who formally agree to participate in the research and sign the Informed Consent Form.	"Individuals with a previous history of neurological diseases, such as Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Cranio-encephalic Trauma and
Stroke; Individuals with cognitive impairment, active lung disease and dependents of mechanical ventilation. Individuals with an infectious process with clinical and / or laboratory abnormalities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-28br3m	Postoperative renal function analysis in Cardiac Surgery in patients undergoing inhalation anesthesia	Recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1322	Postoperative renal function analysis in Cardiac Surgery with Cardiopulmonary bypass in patients undergoing inhalation anesthesia with Sevoflurane using low fresh gas flow	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-24	Hospital São José	Unesp - Universidade Estadua Paulista Júlio de Mesquita Filho - Campus Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-28br3m	<NULL>	Age between 20 and 80 years; both sexes; physical status ASA II and III; preoperative creatinine values are less than 1.3 mg.dL-1.	Patients in emergency or urgent surgery; use of intra-aortic balloon counterpulsation in the preoperative period; left ventricular ejection fraction of less than 0.4; type III diastolic dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-7wcmd6	The effect of Strength Training on Unstable Surfaces on the functional performance of the elderly	Recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1325	Effect of Unstable Surfaces on Neuromuscular Training on the functional performance of elderly with a history of falls: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-30	Universidade de Pernambuco	Centro Universitário Tabosa de Almeida ASCES - UNITA	https://ensaiosclinicos.gov.br/rg/RBR-7wcmd6	<NULL>	Age equal or superior to 60 years; does not present conditions and / or diseases that limit or disqualify participation in the physical training program; stable from the point of view of medication;	Present low adherence to the training (frequency less than 75% of the sessions in a period of one month; present some limiting or incapacitating health impairment during the intervention; are involved in another physical exercise program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:44
RBR-7rbnh6	Effects of Pilates in Sedentary Adults	Recruiting	Intervention	2017-08-15	<NULL>	<NULL>	1333	Influence of Pilates Practice on Physical Composition, Functionality, Body Posture, Life Quality, and Autonomic Modulation in Adults	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7rbnh6	<NULL>	Volunteers of both genders, with technical unfamiliarity with respect to the Pilates Method; to be sedentary; absence of current inflammatory processes derived from musculoskeletal or cardiopulmonary diseases, and absence of previous surgeries on back and abdominal regions.	Presence of some clinical condition at the recruitment moment in order to preclude or to result risk factor to damage or to hurt the volunteer; to use regular medicine which reverberate effects on cardiopulmonary system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-943djg	Effects of branched-chain amino acid consumption in association with omega-3 in clinical-nutritional, cardiorespiratory, metabolic parameters and quality of life in cachectic patients	Recruiting	Intervention	2017-08-16	<NULL>	<NULL>	1334	Impact of branched-chain amino acid supplementation on omega-3 association in clinical, nutritional, cardiorespiratory, metabolic parameters and quality of life in cachectic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal do Maranhão - UFMA	Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq	https://ensaiosclinicos.gov.br/rg/RBR-943djg	<NULL>	Individuals over 18 years of age; pre-cachexia; cachexia; stability (absence of modifications in drug therapy in the last 6 weeks or hospitalizations in the last 3 months).	Individuals over 85 years of age; refractory cachexia (pre-terminal state, life expectancy &lt;3 months, intense catabolism, lack of response to drug therapy); palliative care; use of branded step; water imbalance; allergy to nutritional composition of supplements; withdrawal of consent; adherence to intervention of less than 75%; refusal of proposed supplementation; worsening after intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-2b4bzq	Vibrations to treat rheumatism	Recruiting	Intervention	2017-08-17	<NULL>	<NULL>	1335	Evaluation of the effect of mechanical vibrations generated on oscillating / vibratory platform in patients with systemic lupus erythematosus and bone mass impairment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade do Estado do Rio de Janeiro	Laboratório de Vibrações Mecânicas e Práticas integrativas e complementares - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-2b4bzq	<NULL>	Signature of the Informed Consent Term; patients older than 40 years and female; followed up at HUPE; lupus diagnosed for at least 6 months (ACR criteria 1997, Hochberg, 1997); use of glucocorticoids for 3 years or more; patients with blood pressure (BP) equal to or greater than 100 x 70 mmHg	Presence of neurological / e or psychiatric disease that causes fear to the movements on the oscillating / vibratory platform; severe or incapacitating clinical illness; at the discretion of the investigator; Previous history of low-impact fracture and or classified as severe osteoporosis; personal history of avascular hip necrosis; active smoking; Alcoholism; use of joint protheses; patients refusing to sign the term Of Consent to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-4mgxzw	“Validation of fact-p questionnaire to evaluate quality of life in brazilian men with prostate cancer&quot;	Recruiting	Observational	2017-08-17	<NULL>	<NULL>	1336	“Fact-p instrument validation in brazilian men with prostate cancer&quot;	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4mgxzw	<NULL>	Patients older than 45 years with diagnosis of prostate cancer and staging I, II or III.	Patients with advanced prostate cancer, neurological diseases, insulin-dependent diabetes, penile prosthesis and other tumors; those with difficulty speaking, hearing or understanding the portuguese language; those who have been previously submitted to any kind of treatment of prostate cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3p8g7n	Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects with Staphylococcus aureus Bacteremia Including Infective Endocarditis	Recruiting	Intervention	2016-08-03	<NULL>	<NULL>	1337	A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects with Staphylococcus aureus Bacteremia Including Infective Endocarditis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2015-06-01	Instituto Dante Pazzanese de Cardiologia	INC Research BR Serviços de Pesquisas Clínicas Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-3p8g7n	<NULL>	Male or female at least 18 years old at the time of consent; subject has signed an ICF; at least one blood culture positive for S. aureus within 48 hours before randomization; in addition to the QBC, subject must have at least one of the following signs or symptoms of bacteremia: temperature higher or equal to 38.0°C, white blood cell (WBC) count higher 10,000 or less than 4,000 cells/µL, or higher 10% immature neutrophils (bands) regardless of total peripheral WBC count; tachycardia (heart rate higher 90 bpm); tachypnea (respiratory rate higher 20 breaths/min); hypotension (systolic blood pressure less than 90 mmHg); signs and symptoms of localized catheter-related infection; subject must, at enrollment, have either 1) known right-sided infective endocarditis by Modified Duke’s Criteria, 2) known complicated bacteremia, demonstrated as signs or symptoms of metastatic foci of S. aureus infection, or 3) known bacteremia with at least one of the following risk factors for complicated bacteremia: any venous catheter considered to be the source of the infection, demonstrated by inflammation or purulent drainage from the catheter insertion site AND evidence of catheter-associated thrombosis upon removal; a central venous catheter considered to be the source of infection; a long-term intravascular catheter considered to be the source of infection; new onset cardiac murmur consistent with tricuspid regurgitation; community onset bacteremia; pathogen known to be MRSA at enrollment; duration of symptoms higher or equal to 2 days at time of presentation (prior to start of antibiotic therapy); skin exam findings suggesting acute systemic infection; willing to receive intravenous antibiotics for the duration of treatment; expected survival of at least 3 months; female subjects must be non-pregnant and non-lactating; if sexually active, must agree to use a highly effective method of birth control with partners of childbearing potential during the study and for 1 month after study drug dosing; considered likely to comply with the study procedures and to return for scheduled evaluations.	"Treatment with any potentially effective (anti-staphylococcal) systemic antibiotic for more than 60 hours within 7 days before randomization; requirement or anticipated requirement of non-study systemic antibiotics during the study; presence of an infection source that will not be managed or controlled within the first 3 days of study drug treatment; presence of prosthetic cardiac valve or cardiac device; known or suspected left-sided infective endocarditis (LIE), at enrollment, according to Modified Duke Criteria; at the time of enrollment, known or highly suspected osteomyelitis, meningitis, or metastatic septic foci involving the central nervous system (CNS); Known at the time of enrollment to have MRSA bacteremia that is non susceptible to daptomycin AND has a vancomycin MIC higher or equal to 2 microg/mL; confirmed evidence of a mixed polymicrobial infection with a Gram-negative pathogen that requires non-study antibiotic treatment with agent(s) that have activity against Gram-negative pathogens; previous participation in an anti-infective study during the past 12 months; history of significant hypersensitivity, allergy or intolerance to telavancin; solid organ transplantation or bone marrow transplantation within 6 months before randomization; severe neutropenia, defined as an absolute neutrophil count (ANC) less than 500 cells per microliter, or expected development of severe neutropenia during study; known or suspected human immunodeficiency (HIV) infection with a CD4+ T-cell count less than 200/µl within the previous 6 months; subjects requiring concomitant administration of anti-coagulation therapy AND requiring specific coagulation testing known to have interference by telavancin; severe liver disease, ie, Child-Pugh Class C, or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) more than 10 times the upper limit of normal (ULN); requirement for acute renal replacement therapy; or acute kidney injury (AKI) defined as an acute decrease in creatinine clearance (CrCl) to less than 30 mL/min and at least one of the following: higher or equal to 2x increase in serum Cr or 50% decrease in glomerular filtration rate (GFR) within the 2 weeks prior to enrollment (RIFLE stage 2 injury); oliguria defined as urine output less than 0.5 mL/kg per hour for higher ot equal to 12 hours at any time during screening; Shock or hypotension (supine systolic blood pressure 
less than 80 mm Hg) unresponsive to fluids or pressors within 24 hours prior to randomization; QTc higher than 460 ms (using either the Bazett or Fridericia formula), congenital long QT syndrome, uncompensated or new onset heart failure, aortic stenosis, aortic insufficiency, or mitral insufficiency; serum creatine kinase (CK) higher or equal to 2000 U/L; breast-feeding or pregnant or intending to become pregnant (self or partner) at any time during the study; any other condition that in the opinion of the investigator would jeopardize the safety or rights of a subject or would render the subject unable to comply with the protocol; or any other condition that in the opinion of the investigator may confound the data."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3h4x97	The effect of Dietary Protein Addition on nutritional status and clinical evolution in children and adolescents admitted to the Pediatric Intensive Care Unit	Recruiting	Intervention	2017-08-17	<NULL>	<NULL>	1338	Effect of Protein Supplementation on nutritional status and clinical outcomes in Critically Ill Children on enteral nutritional therapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-19	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-3h4x97	<NULL>	children of both sexes; aged 1 month to 14 years 11 months and 29 days of age; hospitalized for a maximum of 72 hours; with indication of enteral nutrition with polymeric diet.	discharge or death in the first 48 hours; inability to initiate enteral nutrition in the first 72 hours; use of parenteral nutrition; admission for moderate to severe burn; allergy to cow&apos;s milk protein or innate error metabolism; hepatic encephalopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-6z6k27	Physical therapy and funcional performance after breast cancer surgery	Recruiting	Intervention	2017-08-18	<NULL>	<NULL>	1340	Physical therapy after breast cancer surgery: focus on funcional performance and quality of life	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2012-06-25	Universidade Federal de Sergipe (UFS)	Fundação Beneficência Hospital Cirurgia	https://ensaiosclinicos.gov.br/rg/RBR-6z6k27	<NULL>	Women submitted to breast cancer surgery including axillary linfadenectomy, attending physical therapy three times a week, more than 18 years	Women with breast implant, bilateral mastectomy, skin lesions or infeccions on arm, active infectious processes (erysipelas) and breast reconstruction with use of large dorsal and abdominal rectus muscles, breast reconstruction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-4jyr4r	Pilates in the Treatment of Chronic Low Back Pain	Recruiting	Intervention	2017-08-23	<NULL>	<NULL>	1341	Effects of Pilates Method Exercises in Chronic Nonspecific Low Back Pain, Functional Capacity and Quality of Life: A Randomised Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-08	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4jyr4r	<NULL>	Age between 18 and 59 years; Symptoms of pain or stiffness in the pelvic loin region with or without irradiation symptoms to the lower limbs; Pain on most days of the week for more than 3 months; Good understanding of written and spoken Portuguese.	Lumbar disc herniation with or without loss of sphincter control or saddle paresthesia; Equine tail lesion; Spinal surgery; fever; infection; Night sweats or chills; Unexplained loss of weight or appetite; History of cancer or malignancy; Pregnancy or the possibility of pregnancy in the next 6 months; Spinal fractures or diagnosed osteoporosis; Inflammatory disease of the spine such as ankylosing spondylitis and rheumatoid arthritis; Chronic obstructive pulmonary disease and restrictive diseases; Comorbidity that may prevent exercise; Participation in any exercise program in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-5h4y4n	Laser effect in the treatment of mouth wounds caused by the treatment of head and neck cancer	Recruiting	Intervention	2017-08-24	<NULL>	<NULL>	1342	The low level Laser therapy in the treatment of Oral Mucositis in patients with head and neck cancer submitted to radiotherapy and chemotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-12	Universidade Federal de Goiás	Hospital Araújo Jorge - Associação de Combate ao Cancer em Goias	https://ensaiosclinicos.gov.br/rg/RBR-5h4y4n	<NULL>	Volunteers with more than 18 years. Both sexes. Toothed or edentulous. With cancer of the head and neck that will undergo radiotherapy (minimum dose of 50Gy) and chemotherapy	Volunteers with tumors of salivary glands or Sjogren&apos;s syndrome. Patients previously submitted to radiotherapy in the head and neck region or chemotherapy. Patients with lymphoma. Patients with melanoma. Patients with skin cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-6ys9yp	Evaluation of the effect of vitamin E supplementation on vitamin A values of mother and child	Recruiting	Intervention	2017-08-24	<NULL>	<NULL>	1343	Evaluation of maternal vitamin E supplementation on retinol levels in serum and breast milk	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-12	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-6ys9yp	<NULL>	Lactating women; normal birth; term delivery; age between 18 and 40 years.	Women with signs of clinical pathology; Infections; syphilis; HIV; Diseases of the gastrointestinal tract; Liver diseases; heart diseases; diabetes; hypertension; cancer; Mental disorder; Twin childbirth; Newborn with fetal malformations; Abortion history; Use of antithrombotics; Use of supplements containing vitamin E and / or A during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-5hnk3r	Effects of Probiotic Supplementation versus Placebo on Intestinal Function in adult women	Recruiting	Intervention	2017-08-24	<NULL>	<NULL>	1345	Effects of Probiotic Supplementation on Intestinal Function in adult women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade Federal de Mato Grosso	Vitafor©	https://ensaiosclinicos.gov.br/rg/RBR-5hnk3r	<NULL>	"Women between the ages of 20 and 40; who are classified as constipated according to the ROME III criteria are;
Maintain the same diet and routine of daily activities; and sign the Informed Consent Term."	Not to be classified as constipated according to the criteria of ROME III; Not sign the Free and Informed Consent Form; Abstain from treatment for one day; To change their eating routine or exercise during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:45
RBR-3d957w	Long-term effects of Blood Flow Restriction Walk on bone, muscle, and pleasure / displeasure in the elderly	Recruiting	Intervention	2017-08-28	<NULL>	<NULL>	1349	Chronic effects of Aerobic Training with Blood Flow Restriction (rfs) on bone health, neuromuscular performance and perception of pleasure / discharge in elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-05	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3d957w	<NULL>	"Volunteers aged 60 years and over with osteopenia or osteoporosis, in a natural postmenopausal period, with at least 12 months of the last menstrual interval who did not undergo hormonal therapy until 3 months before the study; Do not practice aerobic training; Insufficiently active and functionally independent.
The volunteers who do not have obstructive artery diseases of the lower limbs (DAOMI) with ABI between 0.91 and 1.30; Osteomyelitis associated with intense pain, cardiorespiratory pain that make it impossible to perform physical activity, neoplasias, renal disease. Non-users of drugs that interfere with bone metabolism, non-smokers and those who do not use alcohol regularly will also be included."	Volunteers who have a frequency of less than 85%; Those who give up and those who present osteomyelitis pain or dysfunction during the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-99tdpn	The Effects of Pilates Exercise on Joint Pain and Mobility of Chikungunya Fever Patients	Recruiting	Intervention	2017-08-28	<NULL>	<NULL>	1351	The Effects of the Pilates Method on Pain and Joint Mobility of Chikungunya Fever Patients: A Randomized Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Centro de Ciências da Saúde da Universidade Federal de Pernambuco	Bruna Fernanda Alves de Oliveira	https://ensaiosclinicos.gov.br/rg/RBR-99tdpn	<NULL>	Volunteers with diagnosis of Chikungunya Fever with more than 3 months of symptoms; Chronic phase of Chikungunya fever; Both genders; Age greater than or equal to 18 years.	Contraindication for performing physical exercises at the discretion of the attending physician; Severely limiting cognitive, auditory, visual or motor deficit; Do not sign the Free and Informed Consent Form; patients with pre-existing rheumatological diseases known.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-3cqzfy	Effects of a Home Physical Exercise Program, with Monitoring every 15 Days, on Sleep Quality of the Elderly: a Randomized Clinical Trial	Recruiting	Intervention	2016-12-12	<NULL>	<NULL>	1354	Effects of a Non-Supervised and Guided Home Physical Exercise Program on Elderly Sleep Quality: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-10	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-3cqzfy	<NULL>	Resides in the urban area of the municipality of Senhor do Bonfim-Ba, is 60 years of age or older, has not exercised regularly for at least three months prior to the study, score less than or equal to 5 on the Pittsburgh Sleep Quality Index (PSQI-BR).	Participants with cognitive decline according to the Mental State Mini-Exam will be excluded from the study, they will be performing some treatment for sleep disorder (including the use of sleeping pills more than once a week) and present any Clinical condition that contraindicates the performance of physical activity, identified through a medical and physiotherapeutic evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-4mmvpc	Mindfulness Training for university students with symptoms of Depression, Anxiety and Stress	Recruiting	Intervention	2017-08-29	<NULL>	<NULL>	1358	Mindfulness Based Cognitive Therapy Program for university students with symptoms of Depression, Anxiety and Stress	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4mmvpc	<NULL>	Be regularly enrolled in UFMG; Men and women with age between 17 and 60; Presenting symptoms of depression (mild and moderate) with BDI-II scores between 14 and 28; To present anxiety symptoms with BAI scores&gt; 0To present stress symptoms with scores in PSS&gt; 0	Do not present recent history (past 12 months) of severe psychopathology (psychosis, risk and suicide attempt, Panic Disorder and posttraumatic stress disorder); Having epilepsy or some neurocognitive disorder; Be in psychological treatment (last 6 months); Practice mindfulness meditation with frequency (last 6 months).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-9mvgrq	Effect of three bandages on the flat foot of healthy young adults	Recruiting	Intervention	2017-08-29	<NULL>	<NULL>	1361	Effect of rigid, elastic and hyperelastic banding on excessive pronation of healthy young adults: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Universidade de Brasília	Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9mvgrq	<NULL>	"Authorize the evaluation and the procedure by means of the Free and Clarified Consent in accordance with the resolution CONEP / CNS Nº. 466/2012;
Being male;
Age range between 18 and 30 years;
To present a body mass index between 18.6 and 24.9 kg / m²;
Have no history of injury in the last 6 months in the lower limbs;
Present at least one pronated foot"	"History of musculoskeletal and / or neurological lesions that may affect gait;
History of surgeries and / or traumas of any nature in lower limbs, pelvis or spine in the last six months that may affect gait;
Present allergy to some type of bandage or tissue, evaluated through allergy test;
Have recently done or still do treatment for PE;
Having cutaneous or malignant diseases and bacterial infections in the place to be applied the bandages;
Report any pain or any sign of injury during the evaluations;
Make use of medicine that impairs balance, such as sedative or hypnotic;
Intake of alcoholic beverages within 48 hours prior to evaluation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:46
RBR-7q9xh5	Study Protocol of Effectiveness Evaluation of the Strengthening Families Program in Brazil	Recruiting	Intervention	2017-09-05	<NULL>	<NULL>	1366	Effectiveness, Implementation Quality and Social Validity Evaluation of the Strengthening Families Program	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Instituto de Psicologia da Universidade de Brasília	Secretaria Nacional de Políticas sobre Drogas - Ministério da Justiça	https://ensaiosclinicos.gov.br/rg/RBR-7q9xh5	<NULL>	Families with children between 10 and 14 years of age; concurrent participation of the child/adolescent and at least one parent/guardian; users of public services intended for economically disadvantaged families.	Children/adolescents participating in other evidence-based preventive programs with similar goals; families with rights violations, such as children suffering severe mistreatment; families whose children/adolescents are problematic drug users in need of treatment; and families whose parents are not available to accompany the child/adolescent throughout the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-3qy2f2	"Evaluation of Vitamin D Supplementation on heart health, muscle strength and 
Body fat in twins"	Recruiting	Intervention	2017-09-05	<NULL>	<NULL>	1370	Supplementation with Vitamin D assessment on Physical Fitness: study heritability	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Pós Graduação em Ciências da Saúde	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3qy2f2	<NULL>	Pairs of twins of the same sex. aged 20 and 45. healthy.	individuals with physical disabilities or musculoskeletal limitations that prevent walking or running activity; indivíuos drug therapy related to obesity or using vitamin supplement containing vitamin D; pairs of twins of different sexes; individuals with conditions such as hypertension, diabetes, liver disease, heart disease, infectious or some chronic degenerative disease; pregnant women and individuals who have negative responses to the Physical Activity Readiness Questionnaire (PARq).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-7chtrj	Cognitive therapy in the treatment of resistant social anxiety disorder	Recruiting	Intervention	2017-09-13	<NULL>	<NULL>	1374	Augmenting pharmacological treatment of treatment-resistant social anxiety disorder with cognitive therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-01	Instituto de Psiquiatria da UFRJ - IPUB	Instituto D'Or	https://ensaiosclinicos.gov.br/rg/RBR-7chtrj	<NULL>	A current principal diagnosis of social anxiety disorder by DSM-5 criteria; A history of at least one unsuccessful adequate pharmacological treatment trials, operationalized as lack of response Clinical Global Impression-improvement scale (CGI-I)  greater than or equal to 3, to at least 10 weeks of (i) SSRIs or venlafaxine at adequate dosage; with or without (ii) benzodiazepines (e.g. clonazepam 2 mg/day); A total score on the Liebowitz Social Anxiety Scale (LSAS) of 50 or greater; Man and woman with age of at least 18 years.	Pregnancy, lactation, and women of childbearing potential without accepted forms of contraception; Psychotic disorders, bipolar disorder, mental retardation, a recent history of alcohol or substance abuse or dependence; Severe organic medical disorder; Concurrent use of other psychotropic medications than detailed in inclusion criteria; Current or recent significant suicidality; Any concurrent psychotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-43byv6	Effects of  Electrostimulation at Skin Regions that Correspond to Acupunture Points on the Heart Rate Control of Healthy Subjects	Recruiting	Intervention	2017-09-15	<NULL>	<NULL>	1376	Effects of Transcutaneous Electrostimulation at Acupuncture Points on the Autonomic Balance of Healthy Subjects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Universidade Federal do Estado do Rio de Janeiro	Universidade Federal do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-43byv6	<NULL>	Individuals of both sexes, between the ages of 18 and 30, who declare themselves to be healthy (absence of known chronic or acute pathologies) will be considered for the study.	Age greater than 30 and younger than 18 years, pregnancy, presence of cardiac pacemaker or intermittent cardiodesfibrillator, auditory devices, skull trauma, brain injury, status epilepticus, tetanus, chronic liver disease, chronic kidney disease, patients in use Of Sulfonylurea or Glibenclamide, or who have already undergone previous cardiac surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:47
RBR-78jkbb	Study of the Effects of Surface Electrical Stimulation in Women with spine cord injuries and Urinary Incontinence	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1381	Study of urinary and bladder abnormalities prevalent in women with non-traumatic diseases of the spinal cord and comparative analysis of the conservative therapeutic approach with the techniques of sacral and tibial nervous eletroestimulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-24	Hospital Geral de Fortaleza HGF	Universidade Federal de Minas Gerais UFMG	https://ensaiosclinicos.gov.br/rg/RBR-78jkbb	<NULL>	Women with demyelinating disease attended at the Neurology outpatient clinic of Fortaleza General Hospital who report symptoms of the urgency type to urinate; Losing urine before reaching the bathroom; Go often to the bathroom; Raise the night to urinate; Age greater than or equal to 18 years; Present in the expanded scale of the state of disability of kurtzke score less than 6.5 points; Not being a virgin.	Male; pregnant women; Virgins; Disorder of language or senses that makes it impossible to understand the therapy to be used; Women with expanded state score of kurtzke incapacity greater than 6.5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-4rtyfm	Composite resins restorations in posterior teeth using in association with two materials: bulk-fill resin or glass ionomer cement.	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1385	Class II restorations evaluation using bulk-fill resin base or glass ionomer cement: Clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4rtyfm	<NULL>	older than 18 years; both genders; needed for Class II restorations due to the presence of carious lesions and / or due to replacement of preexisting restorations with caries recurrence, loss or fracture of restorations; presence of at least three vital dental elements to be restored by each participant whose opposing teeth are present; good general health; acceptable level of oral hygiene; presence of at least 20 teeth under occlusion.	high risk of caries and / or periodontal disease; holders of removable or orthodontic appliances; patients with bruxism and / or xerostomia; cavities which, after preparation, do not have a minimum depth of 4 mm in the proximal box; pregnant or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-8w8yh8	Comparative analysis of anti-inflammatory effect of two drugs administered previously surgery to remove wisdom teeth	Recruiting	Intervention	2017-09-19	<NULL>	<NULL>	1386	Comparative analysis of anti-inflammatory effect of a corticosteroid and a NSAID administered previously to impacted thrid molars surgery: a randomized double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-04-17	Universidade de Pernambuco, Campus Arcoverde	Universidade de Pernambuco, Campus Arcoverde	https://ensaiosclinicos.gov.br/rg/RBR-8w8yh8	<NULL>	Individuals of both sexes; Aging between 18 e 35 years in the moment of the intervetion; Have indication for surgical removal of  four third molars with total or parcial bony impaction; Have the right and left third molars in similar position according to Pell and Gregory and Winter classifications; Be at least 10 days without using any drug that influences significantly the inflammatory response; and agree with the terms of the research.	Have any disease or systemic condition that contraindicate the surgical procedure; Continually use drugs that influences significantly the inflammatory response; Be in gestation or lactation; Show signals and symptons of inflammation or infection related to third molars at the moment of the intervention; Total duration of the surgical procedure longer than 90 minutes in any of the interventions; Have, during the surgical procedure, any unusual complication that results in the break of the protocol estabilished in the material and methods of the study; and refuse to participate of the data collection procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9m7cqq	Analysis of the inflammatory response in patients with Chronic Obstructive Pulmonary Disease (COPD) after orange juice intake	Recruiting	Intervention	2017-09-20	<NULL>	<NULL>	1391	In vivo analysis of the inflammatory response in patients with Chronic Obstructive Pulmonary Disease (COPD) after orange juice intake	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Faculdade de Medicina de Botucatu Unesp	Faculdade de Ciências Farmacêuticas USP	https://ensaiosclinicos.gov.br/rg/RBR-9m7cqq	<NULL>	Age above 60 years old; clinical stability characterized by the absence of exacerbation in the last three months and regular use of medication including long-term home oxygen therapy.	Use of antioxidant supplements; use of systemic corticosteroids in the last three months; the presence of other respiratory diseases;  diagnose of other NCDs such as diabetes mellitus II, cancer, severe heart failure, kidney or liver; patients with more than 15% or 200 mL increase in FEV1 after bronchodilator administration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-5mv4y9	Extensive evaluation of the effects of low-power laser on mandibular movements and swelling after maxillary surgery	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	1393	Longitudinal evaluation effects of phototherapy with low-power laser in mandibular movements, pain and edema after orthognathic surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-04	Hopsital Santa Catarina	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5mv4y9	<NULL>	Individuals submitted to bimaxilar orthognathic surgery with mentoplasty; Removal of the third molars to the minimum of six months before the surgery; Both genders; Regardless race; Age range between 18 and 40 years.	Individuals submitted only to monomaxillary surgery or surgeries without chin surgery; Individuals with temporomandibular joint dysfunctions; Rupture in the inferior alveolar nerve during the surgical procedure; Unwanted fractures; Mandibular surgery with the execution time above 2:30 h; Unstable mandibular fixation; Allergy to standardized anti-inflammatories and analgesics; Postoperative infection; Individuals who did not cooperate with the laser therapy protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-7qhddz	The Effect of the Laser Application Before and After Fatigue, in Pain Control and Muscle Damage	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	1395	"Photobiomodulation Before and After the femoral quadriceps Fatigue Protocol of
Healthy patients in Pain Control and Muscle Damage: a controlled study
randomized double blind"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-08	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qhddz	<NULL>	Healthy male; 18 and 30 years of age; BMI less than or equal to 27 kg / m2; classified as active and performing physical activities at least five times a week, totaling a minimum of 150 minutes per week according to criteria Established by the International Physical Activity Questionnaire (IPAC).	Musculoskeletal lesions in the last six months affecting the joints of the hip, knee or ankle; neurological lesions that make it impossible to perform fatigue protocol; skin irritations in the area of irradiation on photobiomodulation; smokers; malignant neoplasm; use of any type of nutritional supplement or agent Pharmacological.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:48
RBR-9znxcq	Strength training as a complementary treatment in the immune system of people living with HIV/Aids: clinical and randomized trial.	Recruiting	Intervention	2017-09-21	<NULL>	<NULL>	1396	"Effect between two methods of interval training of high intensity in the process
Inflammation and subclinical atherosclerosis of people living with HIV/Aids: a study
Double blind clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Universidade Federal de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-9znxcq	<NULL>	Individuals receiving the first antiretroviral regimen; undetectable viral load in the last six months; CD4+cell counts&gt; 200 u/L in the last six months; use of antiretroviral therapy for more than six months; low risk of ischemic cardiac event Framingham; To have an adequate physical condition.	Disorders of locomotion; mental disorders, except anxiety and depression; continuous use of depressant drugs of the Central Nervous System (CNS), except benzodiazepine, use of statins, use of corticosteroids; use of non-hormonal anti-inflammatory drugs; pregnancy or breastfeeding; severe renal and / or hepatic and / or cardiopulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-5bphrt	Analysis of dental biofilm&apos;s proteins and its relation with the effectiveness of the resin infiltration technique to prevent tooth breakdown in children who present molar-incisor hypomineralization (MIH)	Recruiting	Intervention	2017-09-22	<NULL>	<NULL>	1399	Proteomal analysis of dental biofilm and its association with the effectiveness of the resin infiltration technique for the prevention of post-eruptive breakdown in children with molar-incisor hypomineralization (MIH)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-03	Faculdade de Ciências da Saúde - Universidade de Brasília	Secretaria de Educação do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-5bphrt	<NULL>	Children with 8 years old; with good general health; with the first four permanent molars erupted, with at least one being affected by molar-incisive hypomineralization (MIH); who sign the terms of assent; whose parents have signed the TCLEs.	Children who have used any antifungal drug therapy or topical oropharyngeal antimicrobial medications for at least three months prior to collection; children outside the established age range; children with systemic, motor or psychological impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-4mywtr	Knowledge of the Nursing Team about Basic Life Support in Pre and Post-Qualification Babies	Recruiting	Intervention	2017-09-27	<NULL>	<NULL>	1402	Knowledge of the nursing team about Basic Life Support for infants - pre and post Training in Service: a randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	Faculdade de Ciências Médicas e da Saúde Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4mywtr	<NULL>	Staff of the nursing team volunteers; Nursing technicians and nurses; Day and night shift attendants and day laborers; Both genders; Age between 18 and 70 years; Regularly hired in the Institution scenario and crowded in the neonatal intermediate unit; Neonatal intensive care unit; Unit of pediatrics; Center of normal birth and unit of female hospitalization.	Staff of the nursing team volunteers; Nursing technicians and full-time nurses in the neonatal intermediate unit; Neonatal intensive care unit; Unit of pediatrics; Normal delivery center and female inpatient unit that are absent; graduates; As well as transferred from units or dismissed in the period of data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-3z474z	Post traumatic stress disorder and neurons degeneration, stress leading to accelerated aging.	Recruiting	Intervention	2017-09-28	<NULL>	<NULL>	1408	Post traumatic stress disorder and neuroprogression. Trauma and stress increasing alostatic load and accelerating the aging process.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-11-01	Escola Paulista de Medicina	Departamento de psiquiatria da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z474z	<NULL>	Women; between 18-45 years old; raped in the last six months; evaluated at Perola Byington Hospital specialized service; with post traumatic stress disorder.	Menopause; mental retardation; clinical and neurological diseases not under control; schizophrenia; bipolar disorder; drug or alcohol dependence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-4k7zh3	Application of ice in the oral cavity of people using chemotherapy for cancers with 5-fluorouracil: a randomized clinical trial	Recruiting	Intervention	2017-09-29	<NULL>	<NULL>	1409	Cryotherapy applied to people using antineoplastic chemotherapy with  5-fluorouracil: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-20	Universidade Federal do Ceará	Centro Regional Integrado de Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-4k7zh3	<NULL>	Patients with cancer receiving chemotherapy 5-fluorouracil (5-FU) bolus as part of chemotherapy protocol at the beginning of treatment (any cycle); Patients over the age of 18;Both sexes;Patients with scores on the Glasgow scale equal to 15.	Be in radiotherapy in the head region or concomitant esophagus to chemotherapy;Possess smoking habits and alcohol during the research;Have a history of tooth sensitivity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9wnkk7	Effects of Photobiomodulation on anterior serratio muscle, Electromyographic Fatigue, and conjunct action of shoulder muscles	Recruiting	Intervention	2017-10-07	<NULL>	<NULL>	1415	Effects of Photobiomodulation on anterior serratus muscle and electromyographic indicators of Fatigue and synergism of shoulder muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-9wnkk7	<NULL>	Age between 20 and 30 years; full and non-painful active range of motion of the shoulder; elbow and wrist joints; Body mass index (BMI) less than or equal to 27; Considered not very active by the International Physical Activity Questionnaire (IPAQ); have not been in training for at least three months.	Musculoskeletal dysfunction in shoulder, wrist and hand elbow; Weakness of the anterior serratus muscle; winged scapula; history of trauma or previous surgery in the upper extremities; subluxation of the glenohumeral joint; rheumatic, degenerative or neurological disease; patients with diabetes mellitus and fibromyalgia; patients with uncontrolled hypertension; regular intake of drugs and dietary supplements; Fitzpatrick Type Scale Type V and Type VI classification and physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-333g2h	Trial of the safety and efficacy of Dalbavancin versus Active Comparator in children with Skin Infections	Recruiting	Intervention	2017-10-09	<NULL>	<NULL>	1416	"A phase 3, multicenter, open-label, randomized, comparator
controlled trial of the safety and efficacy of Dalbavancin
versus Active Comparator in pediatric subjects with Acute
Bacterial Skin and Skin Structure Infections"	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2016-10-31	Associação Hospitalar de Proteção à Infância Dr. Raul Carneiro	Inc Research Br Serviços de Pesquisa Clínica LTDA	https://ensaiosclinicos.gov.br/rg/RBR-333g2h	<NULL>	"Male or female. Age between 3 months and 17 years. Clinical compatible with infection caused or suspected to be caused by bacteria. Fever, Low leukocytes, cutaneous abscess (pus on the skin), accompanied by redness, edema and/or induration, surgical or traumatic wound infection.
Having: drainage / secretion of pus; fluctuation, localized heat / heat; sensitivity to palpation and / or swelling / induration."	"Clinically significant renal impairment; Clinically significant hepatic impairment; treatment with an investigational drug within 30 days preceding the first dose of
study medication; Patients with low blood arterial pressure; Receipt of antibiotic within 14 days prior to randomization;  An exception is allowed for patients
receiving a single dose of antibacterial drug; Patients with necrotizing fasciitis, or deep-seated infections that would require more than two weeks of antibiotics and and infections caused by fungi, in combination with a bacterial pathogen; Venous catheter entry site infection; Infections involving diabetic foot ulceration, perirectal abscess or a decubitus ulcer; Patient with an infected device, even if the device is removed; Patients whose skin infection is the result of having sustained full or partial thickness burns;
Patients with uncomplicated skin infections such as superficial/simple
cellulitis/erysipelas, impetiginous lesion, furuncle, or simple abscess that only requires surgical drainage for cure.
Concomitant condition requiring any antibiotic therapy that would interfere with the assessment of study drug for the condition under study. Sickle cell anemia
Cystic fibrosis. Anticipated need of antibiotic therapy for longer than 14 days. Patients who are placed in a hyperbaric chamber as adjunctive therapy for the ABSSSI. More than two surgical interventions for the skin infection, or patients who are expected to require more than two such interventions.
Medical conditions in which chronic inflammation may preclude assessment of
clinical response to therapy even after successful treatment (e.g., chronic stasis
dermatitis of the lower extremity)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:49
RBR-9c73cm	Effect of electromyographic biofeedback associated with vocal therapy in dysphonic women	Recruiting	Intervention	2017-10-11	<NULL>	<NULL>	1417	Effect of electromyographic biofeedback associated with vocal therapy in the larynx, voice and muscular electrical activity of dysphonic women: controlled, randomized and blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Faculdade de Odontologia de Bauru/Universidade de São Paulo	Faculdade de Odontologia de Bauru/Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9c73cm	<NULL>	Aged between 18 and 45 years will be included; women; presence of behavioral dysphonia	Report a history of neurological or syndromic diseases will be excluded; Hearing dysfunction; Laryngeal and/or pulmonary surgery; Speech and/or otorhinolaryngological treatment prior to vocal problems; Evidence of behavioral dysphonia of psychogenic origin; Smoking; Participants who do not complete the face-to-face sessions of the proposed interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-34fr3y	Effects of mobile application use on adherence to treatment after Angioplasty.	Recruiting	Intervention	2017-10-16	<NULL>	<NULL>	1419	Effects of use mobile application on adherence to treatment after Percutaneous Coronary Intervention: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-25	Universidade do Vale do Rio dos Sinos - UNISINOS	Associação Pró-Ensino em Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-34fr3y	<NULL>	Have performed percutaneous coronary intervention with stent implantation (regardless of the number of stents and type) for treatment of stable coronary artery disease or for acute event; own smartphone (Android or iOS platform); of both sexes; be over 40 years old.	Patients with motor and / or neurological difficulty to use the smartphone; inability to respond to the questionnaire due to motor and / or neurological difficulty.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-5mzzd4	Effects of Brazilian nut consumption on the expression of factors that regulate inflammation in patients with coronary artery disease	Recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1423	Effects of Brazil nut supplementation (Bertholletia excelsa H.B.K.) in Nrf2 and NFkB expression in coronary arterial disease patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-06-10	Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense	Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5mzzd4	<NULL>	Will be included in the study: men and women over 18 and non-smokers.	Patients with autoimmune and infectious diseases, pregnant and lactating women; Cancer and AIDS; Patients taking catabolic drugs and antioxidant vitamin supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-9p22nj	Telephone intervention for the control of Fatigue in Cancer patients undergoing Radiotherapy	Recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1424	Telephone intervention for the management of Fatigue in Cancer patients submitted to Radiotherapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-15	Escola de Saúde Pública do Ceará	Centro Regional Integrado de Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-9p22nj	<NULL>	Age equal or superior to 18 years; to have cognitive ability to follow the guidelines and to respond to Piper&apos;s fatigue scale through the application of Mental State Minisease (MMSE); score above 60% on the Karnofsky scale; to have a telephone (landline or cellular) to follow the teaching program.	Patients who reported difficulties in receiving telephone calls; and patients taking antidepressants or with chronic pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-8nwxh5	Nutrition and Culinary in the Kitchen Intervention Program with university students	Recruiting	Intervention	2017-10-17	<NULL>	<NULL>	1427	Evaluation of the Cooking Skills Intervention impact on Eating Habits of university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8nwxh5	<NULL>	Being 16 years old or older; being study in the first year of higher education; not living with parents; having a kitchen with basic equipment and utensils available (stove or microwave oven, fridge, cutlery, and pans) to prepare their food; having availability in participating in the cooking classes; signing the Consent Form.	Being study in the distance learning course or postgraduate courses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-37hrf2	Rhizophora mangle (red mango) cream on skin wound healing	Recruiting	Intervention	2017-10-23	<NULL>	<NULL>	1436	Rhizophora mangle cream on skin wound healing. randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Centro de Ciencias da Saúde da Universidade Federal de Pernambuco	Fundação Santa Luzia	https://ensaiosclinicos.gov.br/rg/RBR-37hrf2	<NULL>	Volunteers who will undergo plastic surgery of the upper eyelids at the Santa Luzia Foundation; Both genders; Age between 18 and 65 years; Normal preoperative blood and cardiac tests	Volunteer smokers; Diagnosis of infection in the eyelids; Diagnosis of cancer; Diagnosis of diabetes; Diagnosis of renal, hepatic, hematological or immune pathologies; Diagnosis of obesity; Use of immunosuppressive or corticoid medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:50
RBR-6cs352	Assessment of life habits and health status associated with Fatigue	Recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1440	Fatigue Management Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-09	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-6cs352	<NULL>	men; adults; alternating shift workers; Vitamin D levels less than 30 ng/mL or less than 75 nmol/L; blood glucose increased; lipid profile increased; blood pressure increased; waist circumference increased	clinical history of malabsorption syndrome, kidney disease, liver or thyroid changes; use of anticonvulsant drugs, steroids, hormones or supplements of vitamins and minerals; altered levels of creatinine, calcium and albumin depending on the kit to be used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-2yfbnp	Inflammation Indicators in Saliva from children and adolescents with Spastic Cerebral Palsy	Recruiting	Intervention	2017-10-25	<NULL>	<NULL>	1441	Salivary Biomarkers associated with Gingivitis in children and adolescents with Spastic Cerebral Palsy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Cruzeiro do Sul	Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-2yfbnp	<NULL>	Will be included in this study  individuals with a medical diagnosis of spastic type CP.	"Will be excluded individuals with progressive or neurodegenerative lesions will be excluded; Individuals with CP who are taking any drug that interferes with salivary secretion such as anticholinergics, neuroleptics or benzodiazepines for at least 72 hours prior to salivary collection; Or have undergone surgical procedures to control the external flow of saliva.
Still, individuals who do not collaborate with the salivary collection have used antibiotics in the last month, present symptoms of fever, flu, body aches or diarrhea, or even an inflammatory condition on the oral mucosa as a cold sore."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-66dh44	Evaluation of occupational therapy in reducing psychiatric symptoms in individuals with alzheimer&apos;s disease	Recruiting	Intervention	2017-10-27	<NULL>	<NULL>	1447	A randomized controlled trial to evaluate a method of occupational therapy in reducing neuropsychiatric symptoms in individuals with alzheimer&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-18	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66dh44	<NULL>	Individuals over the age of 60 with dementia diagnosis provided by a physician responsible for the treatment.; elderly people with scores of Mini Mental State Examination (MMSE) between 10 and 20 at the time of screening; elderly people with the presence of one or more neuropsychiatric symptoms or behavioral;  elderly people with caregivers for at least four hours per day	"Visual or hearing impairments dysfunctional, or seriously impaired health status, or those who have changed their medications for medical reasons, come to derail the implementation of assistance;
Concomitant psychiatric illness such as schizophrenia, bipolar affective disorder, Depressive Disorder Severe or Recurrent and Alcohol and Drug Addiction, in serious condition or outside clinical control; Inability to come to the Hospital for the interventions; Caregiver with MMSE &lt;25"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-57cqdx	Delayed Reconstructioon of Irradiated Breast  with fat grafting	Recruiting	Intervention	2017-10-29	<NULL>	<NULL>	1450	Delayed breast reconstruction with autologous fat grafting and  implant  after mastectomy and radioterapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti -CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti -CAISM	https://ensaiosclinicos.gov.br/rg/RBR-57cqdx	<NULL>	Health woman; age between 21 and 70 year-old; who underwent mastectomy followed by radiotherapy, after at least 6 month of adjuvant treatment conclusion and that wish delayed breast reconstruction; agree breast reconstruction with alloplastic material and autologous tissue; woman in oncological follow-up; agree with all necessary procedures, as well as all outpatient returns and proposed photographies; assign the Consent Form; be free of tumor relapse or any radiological alterations	smoking volunteers; history of alcohol or drug abuse; diagnoses of tumor recurrence or radiological alterations in mammary topography; obesity; loss of segment; cognitive difficulties	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-9v37h9	Comparison between two types of Tooth Anesthesia	Recruiting	Intervention	2017-10-30	<NULL>	<NULL>	1451	Efficacy, Latency, Duration and Anesthetic Depth of the traditional Anesthesia method and an In-System Anesthetic Injection without Comfort-In needle in maxillary molars through the Pulp Tester	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-12	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9v37h9	<NULL>	Patients of both sexes; aged between 18 and 30 years; of any ethnic group; marital status; nationality; naturalness; who require local anesthesia to perform class I restorations in the first right (16) and left (26) first molars; also have second right (17) and left (27) molars; no history of pain or trauma; reactive to the electrical stimulus produced by the pulp tester	Patients under 18 years of age or over 30 years; history of alcohol and drug abuse; patient with some pathology that contraindicates the use of local anesthetics; anemia / pregnancy; use of action drugs in the CNS; use of analgesics and anti-inflammatories; pacemaker carrier; use of appliances and orthodontic bands and have no upper molar	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:51
RBR-7bs22c	Effect of foot insoles in patients with rheumatic joint disease	Recruiting	Intervention	2017-10-31	<NULL>	<NULL>	1458	The effect of foot orthoses on balance in  rheumatoid arthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-31	Faculdade de Ciências MédicasUniversidade Estadual de Campinas	Faculdade de Ciências MédicasUniversidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7bs22c	<NULL>	Patients diagnosed with RA according to the criteria of the American College of Rheumatology of 1987; older than 18 years; stable treatment in the last 3 months; possibility of attending scheduled reassessments; to be literate and able to understand the applied questionnaires and the instructions of the tests of strength and balance; use of shoes that allow the use of insoles	Lower limb involvement due to conditions not associated with rheumatoid arthritis; surgical procedure scheduled for the follow-up period; impairment of cutaneous integrity in the lower limbs; amputation of lower limbs; unbalanced vestibular disease; unbalanced visual disturbance; use of insoles in the last 30 days; use of walking aid for short distances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4c7pd5	Evaluation of the protective response of Human Hapillomavirus (HPV) Vaccine in HIV-positive men in the municipality of Campos dos Goytacazes, Rio de Janeiro, Brazil, 2016-2018	Recruiting	Intervention	2017-10-30	<NULL>	<NULL>	1460	Comparison of antibody responses to the Gardasil® Quadrivalent Human Papillomavirus Vaccine in HIV-positive men in the Municipality of Campos dos Goytacazes, Rio de Janeiro, Brazil, 2016-2018	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-15	Infant Care Serviços medicos LTDA	Infant Care Serviços medicos LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4c7pd5	<NULL>	Man with confirmed serological diagnosis of HIV; men aged 18-45 years; men attended at the Center for Infectious and Parasitic Diseases of the Municipal Secretariat of Campos dos Goytacazes; Accept participation in the study; complete the three doses of the quadrivalent HPV vaccine in the dosage regimen offered	Do not agree to participate in the study; abandonment of research; individuals who do not complete the 3 doses of the vaccine; individuals treated at another infectious disease center	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4fr2gf	Effects of combined exercises among individuals with radiating low back-related leg pain	Recruiting	Intervention	2017-11-07	<NULL>	<NULL>	1467	Effects of neurodynamic exercises addition to extension-oriented treatment approach among individuals with low back-related leg pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4fr2gf	<NULL>	Eligible patients may be between 18 and 65 years of age; have radiating pain into one leg below the gluteus for at least 12 weeks with low back pain; mild to severe function limitation; positive SLR test; sufficient understanding to describe signs and symptoms and to answer the specific questionnaires.	Patients will be excluded if they be pregnant; have serious spinal pathology; have exercise contra-indications; have history of lumbar surgery; have severe metabolic or cardiovascular pathology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-3vwdms	Effects of physical activity in chronic kidney disease in diabetic origin	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1473	"Effects of a physical rehabilitation program in patients with diabetic nephropathy,
with different types of exercises compared to proteinuria- randomized clinical trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-12-02	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-3vwdms	<NULL>	"Minimum age of 18,;
Patients with chronic kidney disease; diabetic source characterized by albuminuria greater than 300 mg / g creatinine; with a sample of 50 persons."	"Patients who are on dialysis;
History or evidence of angina or myocardial infarction;
Positive Exercise Stress Test for coronary disease;
Cardiac arrhythmias;
Musculoskeletal restrictions that preclude participation;
Hemodynamic instabilities;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-38nbbx	The effect of vibration training of the whole body using vibratory platform in a patient with chronic pain	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1474	Effect Of Whole Body Vibration Training In Women With Fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-20	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-38nbbx	<NULL>	Women with confirmed diagnosis of fibromyalgia, according to the criteria of the American College of Rheumatology, aged between 35 and 70 years	voluntárias que apresentarem alguma doença concomitante que possa ser exacerbada pela atividade física; gravidez; limitações ortopédicas; doenças inflamatórias; degenerativa; articulares e respiratória ou doenças cardiovasculares; apresentar alguma doença clinicamente instável; lesão do sistema musculoesquelético; estar em acompanhamento com psiquiatra; realizar algum tipo de atividade física; hérnia aguda; trombose; diabetes; epilepsia; doenças metabólicas ou neuromusculares; lesões ortopédicas e próteses; não conseguirem suportar a intervenção; fizer uso de corticoide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-4zzp8b	Identification of optimal amounts of technique to reduce shoulder pain	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1475	Identification of ideal amounts of suprascapular nerve blocks in adhesive capsulitis - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-30	Faculdade de medicina da Universidade Federal de Goiás	Hospital Ortopédico de Goiania	https://ensaiosclinicos.gov.br/rg/RBR-4zzp8b	<NULL>	Participants older than 18 years of age, both sexes with a maximum age of 60 years with primary adhesive capsulitis disease, in phase I of the disease.	Participants with dislocated shoulder dislocation; Arthrosis of the shoulder; Fractures and previous surgeries; Bilateral and secondary adhesive capsulitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:52
RBR-42pvd9	Ultrasound as a method of aid in the treatment of patients with musculoskeletal pain	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1478	Ultrasound as an auxiliary tool in the diagnosis and treatment of patients with Myofascial Pain Syndrome. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-01	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Marcos André Nogueira Frasson Filho	https://ensaiosclinicos.gov.br/rg/RBR-42pvd9	<NULL>	Adult participants 18 years of age or older who voluntarily signed the ICC and who have at least one active or latent Trigger Point located in the cervical, lumbar or shoulder region (trapezius, scapula lift , supraspinatus, infraspinatus), with symptoms for at least 3 months and receiving treatment, without alteration in the dosing schedule, for at least 1 month. These patients may not have undergone other invasive procedures for pain control, such as infiltration with local anesthetics of PGs, in the last 30 days.	"Patients with the following clinical conditions will be excluded from the study:
active skin lesions, uncontrolled diabetes mellitus, neurodegenerative diseases,
fibromyalgia, uncontrolled arterial hypertension, known allergy to the local anesthetic
presence of active bacterial infection, use of anticoagulation with
altered coagulogram, patient request to leave the study and those who have low cognitive level and who do not understand the evaluation scales used.
There will be no limitation between genres."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-5x4397	The Healing Effect of a Herbal Gel Containing Arrabidaea chica in the Treatment of Mouth Wounds in patients with Head and Neck Cancer	Recruiting	Intervention	2017-11-14	<NULL>	<NULL>	1479	Arrabidaea chica for Oral Mucositis in patients with Head and Neck Cancer: a Protocol of a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital de Clínicas da Universidade Estadual de Campinas	Fundação de Amparo à Pesquisa do estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5x4397	<NULL>	Men and women over 18 years old; squamous cell carcinoma of the head and neck; chemotherapy with cisplatin or carboplatin associated with radiotherapy; signs/symptoms of oral mucositis.	Tumor of a histological type other than carcinoma;  nasopharyngeal tumor;  ulcerative lesions; infections in the oral cavity before.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-5nct6d	Effects of a Protocol in a Cellular Application for the prescription of Anticoagulants in the public health system in the city of Ijuí/RS	Recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1481	Evaluation of the Efficacy of a Protocol for patients Anticoagulants of the public health system in the city of Ijuí/RS	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-5nct6d	<NULL>	Physicians working in the basic health unit; regardless of gender, age, years of graduation and years in the unit	There are no criteria for physician exclusion; except personal refusal; risk of cross-contamination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-9pqqpb	Azithromycin in the treatment of Chronic sinusitis: clinical and biopsy evaluation in a controlled study	Recruiting	Intervention	2017-11-16	<NULL>	<NULL>	1483	Azithromycin in the treatment of Eosinophilic nasossinusal polypose: clinical and histomorphological analysis in a randomized masked study with placebo	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9pqqpb	<NULL>	Patients with eosinophilic nasosinusal polyposis; above 18 years of age; with a percentage of eosinophils equal to or greater than 40% that at clinical and endoscopic examination do not present evidence of active nasosinusal infection (ex: purulent secretion in nasal fossa)	Patients with non-eosinophilic polyposis; younger than 18 years; such as cystic fibrosis; Kartagener&apos;s syndrome; antrochoanal polyp; eosinophilic nasosinusal polyposis in the presence of infection; and patients who used corticosteroids or antihistamines in the 15 days prior to the study .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-6pmz49	A clinical trial using Fluoxetine in patients with Premenstrual Syndrome	Recruiting	Intervention	2017-11-17	<NULL>	<NULL>	1485	"A translational approach of the neurobiological determinants of Premenstrual Syndrome
A clinical trial using Fluoxetine in patients with Premenstrual Syndrome"	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2017-05-01	Hospital das Clínicas de Ribeirão Preto	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FAEPA)	https://ensaiosclinicos.gov.br/rg/RBR-6pmz49	<NULL>	Non pregnant women; 18 to 40 years; fill retrospectivily the criteria for premenstrual syndrome according to the American College of Obstetricians and Gynecology	Continuous use of oral contraceptive or brake between pills less than 7 days; current use of injectable contraceptive (monthly or quarterly); current use of contraceptive implants;  current use of drosperinone; use of hormonal DIU; current daily use of benzodiazepines;  current use of drug or any substance which could interfere with esteroidal and/ or fluoxetine&apos;s metabolism;  currency major depressive episode, current generality anxiety, bipolar disorder, schizophrenia or other psychotic disorders, current obsessive-compulsive disorder, current postraumatic stress disorder, current use of ilicit drugs or alcohol (except current use of tobacco);  mild or severe intelectual disability; migraine (except the headache which occurs only in the premenstrual days); epilepsy; pregnancy; women who are breastfeeding; history of intolerance or severe side effects to fluoxetine; history or current other medical condition which could threaten the volunteer&apos;s safety during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-97jm74	Risk factors for falls in the elderly: effects of different programs on Perception, Cognition, Clinical and Physical Status	Recruiting	Intervention	2017-11-21	<NULL>	<NULL>	1487	Associated factors with risk for falls in the elderly: effects of different interventions on Perceptual, Cognitive, Clinical and Functional Aspects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Faculdade Dom Bosco	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-97jm74	<NULL>	Elderly; 60 years or older; women; pre-fragile	Changes that impede participation in the research; reduced cognitive capacity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-95xdzh	Effect of Pilates  exercises on glycemic indexes, urinary and sexual symptoms, mobility and quality of life of women with gestational diabetes mellitus	Recruiting	Intervention	2017-07-13	<NULL>	<NULL>	1490	Effect of Pilates  exercises on glycemic indexes, urinary and sexual symptoms, mobility and quality of life of women with gestational diabetes mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-95xdzh	<NULL>	Age above 18 years; literate; with clinical and laboratory diagnosis of gestational diabetes mellitus; with gestational age between 12 and 30 weeks; BMI &lt;/ = 45; sedentary; non-smokers; clinically stable;released by the physician to perform physical activities	"Pregnant women with neurological impairment; Endocrine and metabolic complications
Due to DMG; obstetric complications such as systemic arterial hypertension, placenta previa, among others; Presenting pre-existing diabetes (type 1 or 2); heart disease; non-attendance at evaluation; Have more than 25% of absences to the treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-5fwhf7	Canabidiol in the treatment of sleep disorder associated with Parkinson&apos;s Disease	Recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1492	Canabidiol in treatment of REM behavior sleep disorder associated with Parkinson&apos;s disease- a double-blind placebo controlled clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade de Sao Paulo	Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5fwhf7	<NULL>	Diagnosis of PD according to criteria of the London Brain Bank in stage 1-3 of the Hoehn and Yahr scale;Over 18 years of age;Diagnosis of RBD according to the criteria of the 3rd edition of the International Classification of Sleep Disorders (CIDS-3);With sufficient severity and frequency to indicate a symptomatic treatment, ie with a frequency of 2 or more episodes per week;That they agree to participate in the study.	In adjustment of antiparkinsonian medications; With diagnosis of dementia; Presenting significant hallucinations (score&gt; 2 in the MDS-UPDRS psychosis item); Introducing delusions; With depression; Without a partner with whom you share your bedroom;With severe or decompensated systemic diseases;With probable mild TCSREM, with sporadic episodes and not clinically significant;Alcoholism or use of illicit drugs;Patients in stage 4-5 of the Hoehn and Yahr scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-33jpyy	Effect of Ginger on reducing nausea and vomiting and on quality of life in patients undergoing Chemotherapy	Recruiting	Intervention	2017-11-22	<NULL>	<NULL>	1496	Effect of Ginger in the occurrence of nauses and vomiting and on the quality of life in patients submitted to Chemoteraphy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Hospital das Clínicas Universidade Federal de Goiás - GO	Hospital das Clínicas Universidade Federal de Goiás - GO	https://ensaiosclinicos.gov.br/rg/RBR-33jpyy	<NULL>	"Aged between 20 and 80 years;
Individuals apt of swallowing capsules; Individuals with a confirmed diagnosis of cancer, being treated with chemotherapy ; Individuals who have undergone at least one CT cycle with the same chemotherapeutic agent and who have experienced nausea or vomiting  as a result of such treatment; Individuals with platelet counts&gt; 100 000/microliters before the initialcycle."	Individuals with ginger allergy or who have made use of it in the last week; Patients on heparin or other anticoagulant medication or who have some bleeding disorder; Patients submitted to chemoterapy associated radiotherapy during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:53
RBR-6pswj7	Intranasal Azelastine and Fluticasone combination in the treatment of adolescents with Allergic Rhinitis	Recruiting	Intervention	2017-11-27	<NULL>	<NULL>	1502	Intranasal Azelastine and Fluticasone combination in the treatment of adolescents with difficult to treat Allergic Rhinitis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Hospital São Paulo - Universidade Federal de São Paulo	Hospital São Paulo - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pswj7	<NULL>	Adolescents between 12 and 18 years old; both genders; difficult to control moderate-severe persistent allergic rhinitis diagnosis; positive cutaneous immediate hypersensitivity test or specific serum IgE to inhalant allergens	Uncontrolled asthma; significant anatomical defects of the upper airway; systemic disease cognitive deficits; upper airways infection in the last 3 weeks; in use of systemic corticosteroid (last 30 days); in use of specific immunotherapy and immunosuppressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-3bkshg	Correlation between post-surgery urine bleeding degree for prostatic increase and surgery outcomes, evaluated by a new scale of urine bleeding	Recruiting	Observational	2017-11-28	<NULL>	<NULL>	1504	Correlation between post-surgery hematuria degree for benign prostatic hyperplasia and intra and perioperative outcomes, evaluated by a new hematuria scale	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-02-05	Hospital Brigadeiro UGA V-SP	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3bkshg	<NULL>	Patients undergoing Benign Prostatic Hyperplasia surgery; any age.	Prostate cancer; Bladder lithiasis; Bladder cancer; Anticoagulants use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-3t83b5	The effect of Natural Latex Membrane on the Closure of the Palate Wound. A Randomized Controlled Clinical Trial.	Recruiting	Intervention	2017-12-01	<NULL>	<NULL>	1507	The effect of Natural Latex Membrane on the Healing of the Donor Site of the Free Gingival Graft. A Randomized Controlled Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3t83b5	<NULL>	Age between 18 and 60 years old; Presence of less than 2 mm of keratinized gingiva associated with teeth with association of a shallow vestibule or high insertion of a brides in the vestibular region of lower incisors; Present inadequate oral hygiene in the region or report of hygiene difficulty; Probing depht up to 3mm; Class I or II gingival recessions (Miller, 1985); Present good systemic health.	Smokers and former smokers; Diabetics; Presence of chronic or aggressive periodontitis; Patients who use medicinal products that alter the connective tissue metabolism; Patients who were chronically anti-inflammatories and antibiotics users; Bruxism; Ethilics; Chemical dependents; Pregnant; History of radiotherapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-2624r4	Assessment of the health of elderly and young people who exercise	Recruiting	Intervention	2017-12-06	<NULL>	<NULL>	1511	Cell health of elderly and elderly people involved in programs resistance training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-01-14	UNESP-Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	UNESP-Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-2624r4	<NULL>	Signature of the informed consent form;both genders; over 60 years old; do not have chronic disabling diseases; not be bedridden; institutionalized or hospitalized; have their own mobility	Osteoarticular limitations that impede the execution of the resistance training program; cognitive limitations that prevent the accomplishment of the proposed evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:54
RBR-7x9gby	Effects of different intensities of Aerobic Training in women with Headache	Recruiting	Intervention	2017-12-11	<NULL>	<NULL>	1516	Effects of different intensities of Aerobic Training in women with Migraine or Tension-type Headache: Randomized and Controlled Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-28	Associação Cauaruense de Ensino Superior	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7x9gby	<NULL>	"Age between 20 and 30 years; 
Nulliparous and nulliparous; For the group with headache: women with clinical diagnosis of migraine or episodic tension-type headache, performed by a neurologist, through anamnesis and neurological examination, based on the diagnostic criteria of the
ICDH; Body Mass Index (BMI) &lt;30kg / m² (WORLD HEALTH ORGANIZATION, 2011); Will be included in the migraine group, women diagnosed with migraine with aura, without aura or both, probable migraine or migraine associated with tension-type headache; 
Women who do not present with severe heart disease, neurological diseases, disabling musculoskeletal diseases, cognitive problems or those with clinical conditions of instability that imply risk and / or inability to participate in the training program;"	"Chronic migraine or chronic tension-type headache; 
Women with low adherence to training (frequency less than 75% of sessions in a one-month period) will be excluded; 
pregnancy; Drug or alcohol abuse; 
Use of antipsychotic or antidepressant medications;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-8p484w	Comparison between Internal Jugular Vein versus Axilar Vein for implantable ports	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1521	Internal Jugular vein versus Axilar Vein with single-incision for Implantable Ports: a prospective and randomized study	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-04-17	AC Camargo Cancer Center	AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-8p484w	<NULL>	Minimum age 18; cancer patients; only catheter for chemotherapy; ECOG (performance status) from 0 to 2; signed informed consent form.	Non compliance; anticoagulant therapy; coagulopathy (platelet count below 50,000 and/or protrombin time above 18s); death within 30 days after the procedure; another catheter in superior vena cava; previous long term catheter in superior vena cava; obesity (IBM&gt;40 Kg/m2).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-243w6r	Rehabilitation of the Patients with Low Back Pain	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1523	Low-Level Laser Therapy and Manual Therapy in the Treatment in Patients with Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-15	Universidade Paulista - UNIP	Universidade Paulista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-243w6r	<NULL>	Symptomatic volunteers with complaints in the lower back, more than 3 months of complaints	Patients with rheumatic; polytraumatic; cognitive deficits; central or peripheral nervous system lesions; patients with fracture sequelae in the lower limbs; fractures in lumbar spine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-7zbxq5	A physiotherapy protocol based on the preferences of the individual with Parkinson disease for the health empowerment	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1524	Efects of physiotherapy with aproach based on patient preferences and conventional physiotherapy in motor and non-motor symptoms of individuals with Parkinson disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade do Estado de Santa Catarina	University of Miami Miller School of Medicine	https://ensaiosclinicos.gov.br/rg/RBR-7zbxq5	<NULL>	Diagnosis of Parkinson&apos;s disease; stages I through IV according to the Scale of HOEHN and YAHR; individuals correctly performing the drug treatment.	Individuals unable to practice physical exercises; Serious cognitive alterations; contraindication to any of the outcome tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-79z2sh	Formulation effect in patients with Alopecia Areata	Recruiting	Intervention	2017-12-14	<NULL>	<NULL>	1528	Pilot study of the application of formulation containing Clobetasol Propionate Nanoparticles for the treatment of Alopecia Areata	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital Regional da Asa Norte - HRAN	Laboratory of Food, Drug and Cosmetics (LTMAC)	https://ensaiosclinicos.gov.br/rg/RBR-79z2sh	<NULL>	Male or female patients; aged between 18 and 65 years; confirmed clinical diagnosis of alopecia areata; Not responding to previous treatments for alopecia; Not being treated for alopecia for at least 6 months; Female pattern of alopecia with Ludwig grade II or higher; Absence of telogen effluvium in the last 6 months; Not allergic to any compound of the formulations	Hyper or hypothyroidism diagnosed during the study or decompensated; FAN greater than or equal to 1:320; Serum ferritin less than 40 ng/mL; Contraindications to the use of clobetasol propionate; Pre-treatment (within 6 months) with any of the active substances: Minoxidil hydrochloride and Finasteride.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-784f3y	Use of Vitamin E Cream for Prevention of Skin Lesions in Women with Breast Cancer who undergo radiotherapy	Recruiting	Intervention	2017-12-18	<NULL>	<NULL>	1529	Topical Application of Nanoparticles containing Vitamin E for Prevention of Radiodermatitis in Women with Breast Cancer: Randomized Clinical Trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-09-11	Escola de Enfermagem da Universidade de São Paulo	Santa Casa de Misericórdia de Passos	https://ensaiosclinicos.gov.br/rg/RBR-784f3y	<NULL>	be 18 years or older; and present the entire skin on the day radiotherapy begins.	previous radiotherapy in the same area; previus radical mastectomy; be pregnant; have a malignant fungating wound in the irradiated area; report history of adverse reaction to components of the cream formula; be on concomitant chemotherapy; use concomitant topical or systemic anti-inflammatory therapy; collagen diseases such as systemic lupus erythematosus and scleroderma; receive another type of intervention to prevent radiodermatitis, not included in the standard or experimental protocol; and refuse to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-6m8zhy	Clinical cohort of children with microcephaly associated with Congenital Zika Infection in Pernambuco	Recruiting	Observational	2017-12-14	<NULL>	<NULL>	1533	Clinical cohort of children with microcephaly and other abnormalities associated with congenital zika infection in Pernambuco	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-10-10	Fundação Oswaldo Cruz	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-6m8zhy	<NULL>	Pregnant women with cutaneus rash and children with microcephaly and oothers children com microcefalia and others clinical conditions related to Zika Virus	Pregnant women with rash caused by others provd  Arboviroses infection  or infection  by TORCHS group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:55
RBR-2jcc8d	Impact of Pilates mat Compared to Walking on Fat-Treated Rolling Stones and Insulin Resistance	Recruiting	Intervention	2015-05-25	<NULL>	<NULL>	1541	Impact of Pilates mat versus aerobic exercise on hepatic steatosis and insulin resistance in women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-05	Hospital Universitário- Prof Edgard Santos- UFBA- HUPES	Hospital Universitário- Prof Edgard Santos- UFBA- HUPES	https://ensaiosclinicos.gov.br/rg/RBR-2jcc8d	<NULL>	Female volunteers; aged between 30 and 70 years; abdominal obesity; hepatic steatosis confirmed by ultrasonography	Volun smokers; alcoholic; decompensated heart disease; decompensated liver disease; physically active	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-9fjfnh	Curcuma longa (Tumeric) as an auxiliary treatment for Idiopathic Childhood Nephrotic Syndrome	Recruiting	Intervention	2018-01-02	<NULL>	<NULL>	1542	Curcuma longa as adjuvant in the treatment of Idiopathic Childhood Nephrotic Syndrome	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9fjfnh	<NULL>	The study will include all patients older than one year; who have the diagnosis of idiopathic childhood nephrotic syndrome; who are followed up at the Childhood Nephrology Clinic of the Clinics Hospital of Ribeirão Preto of the University of São Paulo,  (i.e. ANEI); and whose parents or legal guardians authorize participation through signature of informed consent.	Will not be included in the project those patients younger than one year; those with nephritic syndrome characteristics; with another etiology for the nephrotic syndrome, as secondary causes (e.g. IgA nephropathy, membranoproliferative glomerulonephritis, systemic lupus erythematosus and secondary to Infectious diseases); or whose parents or legal guardians disagree with their participation in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-95scpc	Nutritional status and level of inflammation of patients with inflammatory bowel disease in saffron use in outpatient care	Recruiting	Intervention	2018-01-05	<NULL>	<NULL>	1546	Nutritional status and inflammatory profile of patients with Ulcerative Colitis in use of turmeric in outpatient care	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2016-09-08	Hospital das Clínicas Universidade Federal de Goiás - GO	Instituto Goiano de Gastroenterologia Ltda	https://ensaiosclinicos.gov.br/rg/RBR-95scpc	<NULL>	patients clinically diagnosed with ulcerative colitis ; changes in the examination of fecal calprotectin ; age greater than 18 years; outpatient care ; both sexes ; Clinically stable ; noninstitutionalized ; have performed biopsy and sigmoidoscopy to confirm the diagnosis ; accept participate.	allergy saffron ; heart disease ; liver disease ; leukopenia ; thrombocytopenia ; pancreatitis ; gallstones ; kidney disease; decompensated diabetes ; pneumonia; sepsis or infection ; pregnant women ; nursing mothers ; patients with difficulty swallowing .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-27fmyt	Effects of nutritional counseling and / or supplementation with Whey Protein on the nutritional status and metabolism of individuals with risk factors for Cardiovascular Diseases	Recruiting	Intervention	2018-01-05	<NULL>	<NULL>	1551	Effects of nutritional orientation and or supplementation with Whey Protein on the nutritional and metabolic status of individuals with risk factors for Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-27fmyt	<NULL>	Inclusion criteria were established for the participation of the research: adult women, aged between 20 and 59 years and BMI between 25 and 40 kg / m2.	Adult women diagnosed with renal, cardiovascular, hepatic, cancer, pregnant or lactating diseases will be excluded from the study, following a specific diet; Chronic alcoholics; On the use of anti-inflammatory medications or medicines that affect appetite or body weight; In inflammatory or infectious process on the day of collection; Who have participated in any food restriction program, in the use of food supplements in the last six months and lactose intolerant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-36zcfg	The Effects of Auriculotherapy in Women With Breast Cancer During Chemotherapy Treatment	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1552	The effects of auriculotherapy in women with breast cancer undergoing chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-15	Hospital de Clinicas da Universidade Federal do Paraná	Hospital de Clinicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-36zcfg	<NULL>	Women; Diagnosis of breast cancer; Chemotherapy treatment; Age between 18 and 99 years	Using anxiolytics; Antidepressants; Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:56
RBR-23nyf4	Comparison of the effects of Mental Practice protocols for Functional Mobility and Risk of Falls in Parkinson&apos;s disease	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1555	Mental Practice protocols for Functional Mobility and Risk of Falls in Parkinson&apos;s disease: A Randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-23nyf4	<NULL>	"Patients with clinical diagnosis of idiopathic Parkinson&apos;s disease according to Ordinance No. 228/2010 of the Ministry of Health of Brazil;
Both sexes;
Patients aged 18-80 years;
Stage 1 to 3 of Hoehn and Yahr&apos;s original scale."	Other neurological diseases; orthopedic, rheumatic and / or vascular pathology, with moderate or severe functional restriction in one or both lower limbs; uncontrolled hypertension and / or cardiac or respiratory disease that limits the execution of the protocol; with lowering of the cognitive level; with medical restriction to perform exercises; unable to perform the motor imagination, in physical therapy or occupational therapy for 3 months or more; with moderate to severe depression; with visual and auditory deficits that do not guarantee a good participation in the protocol; after deep brain stimulation surgery; with vestibular alterations; with lack of sensitivity in the lower limbs; users of orthosis for lower limbs; User of prosthetics; with edemas in the lower limbs and amputees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-3jy7kg	Effects of Constraint Induced Moviment Therapy associated with Elastic Bandage in the upper-extremity of patients with loss of acute or chronic motion	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1556	Effects of Constraint Induced Moviment Therapy associated with Funcional Bandage in the upper-extremity of acute and chronic hemiparetic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-12-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3jy7kg	<NULL>	Hemiparetic individuals in upper limb; both genders; 5 to 60 years; Signature of the Informed Consent Form (TCLE); diagnosis of neurological injury; minimum motor criterion for the execution of the TCI; without cognitive deficit.	Allergy to Functional Bandage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-73c7bz	Pilates in posture and body awareness in the blind.	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1557	Postural analysis and body awareness in visually impaired individuals after intervention with the pilates method	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Faculdade Santo Agostinho	Faculdade Santo Agostinho	https://ensaiosclinicos.gov.br/rg/RBR-73c7bz	<NULL>	Be between 20 and 50 years old, of both sexes, be blind, be frequent attenders of the Association of blind people of the State of Piauí, have a good cognitive understanding.	Acute fracture, spinal cord tumor, acute infections, malignant spinal neoplasm, frank disc heation with signs of progressive neurological deficit, neoplasms of muscle tissue or other soft tissues, generalized congenital hypermobility, syringomyelia, etiology hydrocephalus unknown, labyrinthitis, autism, osteoporosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-64vys2	Comparison of Exercises for Urinary Incontinence with and without Electrical Stimulation	Recruiting	Intervention	2018-01-08	<NULL>	<NULL>	1559	Comparison of a Kinesiotherapy Protocol with and without Association of Posterior Tibial Nerve Stimulation for Mixed Urinary Incontinence: A Randomized and Blind Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-64vys2	<NULL>	To present urinary incontinence; Have not performed any previous physiotherapeutic treatment for pelvic dysfunctions; Do not have pacemakers or cardiovascular disease; Do not be pregnant.	volunteers with infectious disease; volunteers with prolapse grade III or IV; complaint of unbearable pain upon physical examination of muscle strength; more than 3 absences during the treatment period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-7543ns	Auricular acupuncture for post-operative nausea and vomiting.	Recruiting	Intervention	2018-01-09	<NULL>	<NULL>	1560	Influence of Auricular Acupuncture in order to prevent nausea and vomiting after Laparoscopic Cholecystectomy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Faculda de Ciências Médicas Universidade de Pernambuco	Faculda de Ciências Médicas Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7543ns	<NULL>	adult females between; 18 and 70 years old; with Body Mass Index under 35; who belong to classification 1 and 2 of the American Society of Anaesthesiology; submitted to uncomplicated Laparoscopic cholecystectomy.	Laparoscopic cholecystectomy with surgical or anesthetic complications; operation time longer than 90 minutes; nausea and vomiting on the immediate preoperative time; patient ASA 3 or more; use of antiemetic 12 hours before the procedure; continuous use of analgesic or corticoids; abusive history of alcohol and drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-2f3fvr	Effects of Aquatic Exercises on the heart in Overweight adults	Recruiting	Intervention	2018-01-11	<NULL>	<NULL>	1562	Effects of Deep Water Running on the cardiac autonomic control and functional capacity in adults with Overweight and Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-2f3fvr	<NULL>	Participants of both genders; adults ranging from 39 to 59 years of age; with overweight or obesity I.	Volunteers with cardiorespiratory, musculoskeletal or neuromuscular diseases that impede the performance of the aquatic training program; hydrophobia; skin wounds; and infectious-contagious diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-35ygdr	Relation of Anemia in pregnant women, oral Infection and Low birth weight	Recruiting	Observational	2018-01-11	<NULL>	<NULL>	1564	The influence of Maternal anemia mediated Periodontitis on Low birth weight	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2013-01-01	Universidade Estadual de Feira de Santana	Universidade Federal do Recôncavo da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-35ygdr	<NULL>	Pregnancy. Fetal gestational ages between 8 and 32 weeks. Assistance from the public health system. Live births, full-term births.	Women if they had a twin pregnancy. Cases of miscarriage of less than eight weeks. History of bleeding that required hospital treatment for at least 24 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-4c6s7s	Epsilon aminocaproic acid and Tranexamic acid in Knee prosthesis	Recruiting	Intervention	2018-01-12	<NULL>	<NULL>	1565	Epsilon Aminocaproic Acid(EACA) and Tranexamic Acid(TXA) in Total Knee Arthroplasty	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-07-01	Associação Evangelica Beneficiente de Londrina	Associação Evangelica Beneficiente de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4c6s7s	<NULL>	Patients clarified about the research and with knee tricompartmental osteoarthrosis of both sexes; with indication of total knee prosthesis; No diagnosis of inflammatory disease; no history of atrial fibrillation; deep vein thrombosis; previous pulmonary embolism	Use of anticoagulant medications up to seven days before surgery. Anterior surgeries in the same knee with cicatricial alterations that make it impossible to close the joint capsule. Patients who during the operative act require the release of soft parts that are more extensive than the programmed ones that make it impossible to properly close the joint capsule.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-6gdktv	Effects of PEEP-ZEEP technique on pulmonary secretion removal and respiratory system.	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1567	Effects of PEEP-ZEEP Maneuver on pulmonary secretion clearance and respiratory mechanics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-09	Universidade Federal do Triângulo Mineiro	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gdktv	<NULL>	Patients with pulmonary secretion on mechanical invasive ventilation; hemodynamically stable (MBP higher than 65 mmHg); PEEP lower or equal than 10 cmH2O; oxygen inspiratory fraction lower or equal than 0,4; peripheral oxygen saturation higher than 90%.	Intracranial hypertension; cor pulmonale; pulmonary hypertension; pregnancy; pneumothorax not drained; bronchospasm; rib fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:57
RBR-2mf595	Serious Game for evaluation and treatment in Stroke	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1568	Evaluation and rehabilitation using a Serious Game in hemiparetic patients for Stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-01	Universida do Estado de Santa Catarina (UDESC)	Associação Catarinense de Ensino (ACE) / Faculdade Guilherme Guimbala (FGG)	https://ensaiosclinicos.gov.br/rg/RBR-2mf595	<NULL>	"Stroke hemiparetic patients, clinically stable and in the subacute or chronic phase of the disease;
Age range equal to or greater than years;
Agree and show interest in participating in the project from start to finish."	"Patients who present hemiparesis due to other pathologies, other than stroke, as well as hemiplegic patients;
Patients who present bilateral motor impairment, which impedes characterization as hemiparetic;
Patients with severe visual and / or auditory impairment;
Uncooperative and / or severely cognitively impaired patients;
Patients who can not independently stand up (use of aid devices: crutch, cane or walker);
Patients who are performing any type of rehabilitation for the trunk and lower limbs (hydrotherapy, conventional physiotherapy, physical exercises in general)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3vcqt9	A comparative study between two surgeries for women with Stress Urinary Leakage: Minisling (Solyx) and Transobturator Sling (Obtryx II)	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1569	Randomized controlled trial between Minisling (Solyx) vs Transobturator Sling (Obtryx II) in women with Stress Urinary Incontinence (SUI)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Hospital da Mulher José Aristodemo Pinotti	Boston Scientific	https://ensaiosclinicos.gov.br/rg/RBR-3vcqt9	<NULL>	"Women with 18 years and/or older.
Positive cough stress test for SUI or positive findings of stress urinary incontinence at urodynamic study (UDS).
Post-voiding residue &lt; 100 ml or less 20% of total urinary volume
Maximum bladder capacity over 300 ml"	"Women with overactive bladder or recurrent UTI or previous urogynecological surgeries.
Previous pelvic radiotherapy. 
Presence of pelvic organ prolapse (POP) stage 2 and over.
Past or recent history of bladder lithiasis, inferior urinary fistula or diverticulum. 
Current use of anticoagulants.
Previous surgical history of foreign-body reaction like (eg. history of surgery with prosthetic complications)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9tmm4d	Analysis of the mental and physical exhaustion and the relation with immune response of cancer patients submitted to exergames.	Recruiting	Intervention	2018-01-15	<NULL>	<NULL>	1571	Analysis of mental and physical fatigue and its relatonship with cytokines in cancer patients submitted to exergames practice. Randomized, controlled, follow-up and cross-over study.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-05	Universidade Federal de Alfenas	Fundação de apoio à pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9tmm4d	<NULL>	"Experimental group 1: individuals with cancer; of both genders; age between 18 and 80 years; in chemotherapy; in radiotherapy; classification of stage 0; I; II and III; surgical post with medical release for the practice of physical activities.

Experimental group 2: individuals with cancer; of both genders; age between 18 and 80 years; in chemotherapy; in radiotherapy; classification of stage 0; I; II and III; surgical post with medical release for the practice of physical activities."	Individuals without cancer diagnostic; cognitive disorders that hinder the explanation of the handling of virtual environments; serious infectious diseases; disabling diseases in upper and lower limbs; patients with myopathies; diseases with recognized change of collagen; with neurological diseases; for personal reasons do not wish to participate; previous contact with exergaming.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-2z7mtr	Inspiratory Muscle training in patients with traumatic brain injury undergoing prolonged mechanical ventilation: Randomized controlled trial study	Recruiting	Intervention	2018-01-17	<NULL>	<NULL>	1574	Inspiratory Muscle training in patients with traumatic brain injury undergoing prolonged mechanical ventilation: Randomized controlled trial study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-04-01	Hospital de Base do Distrito Federal	Escola Superior de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-2z7mtr	<NULL>	adults (aged from 18 to 60 years); traumatic brain injury individuals with mechanical ventilation stay at least 72 hours	previously diagnosed neuromuscular diseases;  intracranial hypertension; pregnancy; platelets &lt; 40.000; hemodynamics instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-3wss27	Effects of Respiratory Muscle Training in Heart Disease and Sleep Apneia	Recruiting	Intervention	2018-01-18	<NULL>	<NULL>	1575	Effects of Inspiratory Muscle Training in patients with Chronic Heart Failure and Sleep Apneia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-30	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Ciências da Saúde da Universidade Metodista de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-3wss27	<NULL>	Volunteers with left ventricular ejection fraction&gt; 50%; functional classification of I to III of the disease, according to the New York Heart Association (NYHA); both genders ; aged between 30 and 75 years;  non-smokers; non-alcoholic; without chronic obstructive pulmonary disease (FEV1 / FVC&gt; 70% and FEV1&gt; 70% predicted); diagnosed sleep apnea (central apnea / hypopnea index greater than or equal to 5 per hour).	Volunteers with unstable angina; myocardial infarction in the last six months; osteomioarticular, rheumatic and cognitive diseases; systemic arterial hypertension and uncontrolled diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-4zrwtz	Assessment of the risks and benefits of Vancomycin use in patients with infection	Recruiting	Observational	2018-01-18	<NULL>	<NULL>	1579	Evaluation of the safety and efficacy of Vancomycin use in septic patients admitted to the Clinical Hospital of the Botucatu Medical School - UNESP	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-06-01	Departamento de Clínica Médica da Faculdade de Medicina de Botucatu	Departamento de Clínica Médica da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4zrwtz	<NULL>	Septic patients older than 18 years using vancomycin for at least 48 hours admitted to 2 intensive care units and 4 wards (clinical and surgical). Patients using vancomycin and requiring acute renal support will be included in an additional vancomycin pharmacokinetic / pharmacodynamic research protocol	Patients under 18 years old; Pregnant women;  stage 5 CKD (creatinine clearance less than 15 mL / min, according to the MDRD formula); Kidney transplant recipients; Patients taking vancomycin for less than 48 hours and those admitted or who progressed with acute kidney injury prior to the start of their use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9vqhg7	TENS effect and exercises in menstrual pain	Recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1583	"TENS effect in Primary Dysmenorrhea 
and its influence on central sensitization pre and post exercise: randomized clinical trial"	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9vqhg7	<NULL>	women; age between 11 and 35 years; pelvic pain lasting 8 to 72 hours during the menstrual period; intensity equal to or greater than 3 on the numerical scale; nulliparous.	"use of contraceptives during the study period; frequent use of analgesics or anti-inflammatories during treatment; presence of pelvic disease; pregnant; history of abortion;
musculoskeletal damage or excessive pain in any joint that may limit participation in an exercise program or evaluation of functional parameters; psychiatric disorder, cognitive decline or dementia influencing the communication process; under physiotherapeutic treatment during the study;
presence of contraindications for the use of TENS, such as ulceration or allergy to electrode material; prior use of TENS; chronic use of opioids or antidepressants; - reduction of sensitivity in the places where the electrodes will be placed; history of previous surgery in the uterus; presence of chronic decompensated diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-796fgc	Analysis of the trunk muscles in people with low back pain after treatment through Pilates	Recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1586	Electromyographic analysis of the trunk muscles in subjects with non-specific low back pain submitted to a Pilates protocol	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-11-11	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-796fgc	<NULL>	"Low back pain group: both sexes, nonspecific low back pain, age between 18 and 40 years;
Control group: both sexes, aged between 18 and 40 years, clinically healthy;"	Specific low back pain; congenital malformation; sensory or motor changes, illnesses that impede the performance of the exercises, Pilates exercises for less than 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-9yw9fk	Manual reaching behavior training in socioenvironmental risk infants	Recruiting	Intervention	2018-01-22	<NULL>	<NULL>	1587	Effect of specific training on reaching behavior  of socioenvironmental risk infants: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9yw9fk	<NULL>	Socioeconomic risk infants with adequate birth weight for gestational age, Apgar between 7 and 10 in the first and fifth minutes, respectively, classified among classes C - E in the Brazilian Economic Classification Criteria of the Brazilian Association of Research Companies (ABEP), and which are in the &quot;less than adequate&quot; descriptive category in the Affordances Instrument in the Home Environment for Motor Development - Baby Scale (AHEMD-IS).	Infants whose medical records report the occurrence of 1) orthopedic (recent fracture) and / or musculoskeletal disorders that prevent the extension of the upper limbs, 2) visual and auditory changes, 3) cardiorespiratory changes, 4) anoxia, 5) premature birth, 6) signs of neurological complications (eg seizures, intracranial hemorrhage), 7) congenital malformations and 8) genetic syndromes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:58
RBR-4233sv	Pain in preterm new born and physiotherapy.	Recruiting	Intervention	2018-01-23	<NULL>	<NULL>	1590	Analysis of Neonatal Pain in Premature infants with Respiratory Distress Syndrome and its influence on physiological parameters and the Physiotherapeutic treatment hemodynamic in Intensive Care Unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-05	Fundação Santa Casa de Misericórdia do Pará	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-4233sv	<NULL>	Volunteers with gestational age between 28 and 37 weeks, according to the who criteria; weight less than or equal to 2500 g; they&apos;re in use of invasive mechanical ventilation, with diagnosis of Respiratory distress syndrome and with indication for respiratory physiotherapy.	It will be excluded  premature newborns with congenital malformations, chromosomal syndromes, intracranial bleeding or clinical neurological changes of any nature; those with chest or abdominal drain; use of sedation above 2 mg/kg; in use of vasoactive drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-2q5wy8	Study on the use of surgical glue in the repair of cuts in the vagina	Recruiting	Intervention	2018-01-25	<NULL>	<NULL>	1593	Clinical trial on the use of glue surgical to repair episiotomies and perineal lacerations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-03	Escola de Artes Ciências e Humanidades da Universidade de São Paulo	Autarquia Municipal de Saúde de Itapecerica da Serra	https://ensaiosclinicos.gov.br/rg/RBR-2q5wy8	<NULL>	To be primiparous; have in vaginal birth with episiotomy and first and second degree perineal tears	Have vaginal birth with intact perineum; third or fourth degree perineal tears; give up to continue the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-5ffbxz	Treatment with sloping treadmill to improve the physical conditioning of people with Stroke	Recruiting	Intervention	2018-01-25	<NULL>	<NULL>	1596	Effects of inclined treadmill on cardiovascular and functional parameters of individuals with Stroke: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-19	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5ffbxz	<NULL>	The participants will be selected according to the following criteria: diagnosis of the first episode of unilateral stroke (ischemic or hemorrhagic) that resulted in walking deficits; sequelae time equal to or greater than six months; age greater than 20 years and equal to or less than 70 years; ability to walk without personal assistance indoors (FAC scores equal to or greater than 3 (MEHRHOLZ et al., 2007); comfortable walking speed in the ground equal to or less than 0.9 m / s (limited community walkers), according to the classification proposed by Fulk and co-workers (2017); and ability to understand and obey simple motor commands.	Exclusion criteria will include: being in the gestational period; presenting instability in cardiac conditions (uncontrolled heart disease) and / or heart failure (New York Heart Association (NYHA) scores equal to or greater than 3 (REMME &amp; SWEDBERG, 2001); other clinical conditions affecting walking; have severe pain and / or discomfort, which impedes the performance of the proposed activities;  presented decompensations in the systemic arterial pressure, with systolic and diastolic values above, respectively, 200mmHg and 110mmHg before and / or after training (BALADY et al., 1998); and heart rate above the submaximal values allowed during training, maintained even after pauses, calculated using the formula [FCsub = 0.75 x (220-age)] (FOX III et al., 1971), where FCsub = submaximal heart rate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-88jb56	Interventions to hypertension control	Recruiting	Intervention	2018-01-26	<NULL>	<NULL>	1597	Factors associated with no control of hypertension and effectiveness of individual interventions and group for the promotion of disease control	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-88jb56	<NULL>	Hypertension patients with more than 18 years old and uncontroll hypertension (blood pression rate more that 140/90 mmHg) and participed of transversal study.	Patients with secundary hypertension. Institutionalized patients, with mental illness or disabling chronic illness or a life expectancy of less than one year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:17:59
RBR-979wh3	Prevention of Acute Pancreatitis after examination of the bile ducts using only guidewire versus guidewire and contrast	Recruiting	Intervention	2018-01-30	<NULL>	<NULL>	1604	Prevention of Post ERCP Pancreatitis (PEP): Guidewire versus Guidewire and Contrast	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-979wh3	<NULL>	Consecutive patients over 18 years of age who are referred to the Radiology Center of the São José Pavilion (Biliary Endoscopy Service of Santa Casa / UFCSPA) will be included to perform CPER that, after due explanations about the study, agree to participate and sign the term of free and informed consent.	Patients who: have previously undergone endoscopic retrograde cholangiopancreatography, refuse to participate, and those whose ERCP is performed during the course of acute pancreatitis will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-2xt4yk	"A Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) 
in Subjects with Previously
Untreated Mantle Cell Lymphoma"	Recruiting	Intervention	2018-01-30	<NULL>	<NULL>	1605	"A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter
Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) 
in Subjects with Previously
Untreated Mantle Cell Lymphoma"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-11-01	Hospital São Rafael/Monte Tabor-BA	INC Research	https://ensaiosclinicos.gov.br/rg/RBR-2xt4yk	<NULL>	"Men and women, &gt;65 years of age;
Pathologically confirmed MCL, with documentation of monoclonal CD20+ B cells that have a chromosome translocation t(11;14)(q13;q32) and/or overexpress cyclin D1;
MCL requiring treatment and for which no prior systemic anticancer therapies have been received;
Presence of radiologically measurable lymphadenopathy or extranodal lymphoid malignancy (as defined by Lugano Classification for NHL);
Eastern Cooperative Oncology Group (ECOG) performance status of &lt; 2
Men who are sexually active and can beget children must agree to use highly effective forms of contraception during the study and for 90 days after the last dose of acalabrutinib, 6 months after the last dose of bendamustine, or 12 months after the last dose of rituximab, whichever is longest;
Men must agree to refrain from sperm donation during the study and for 90 days after the last dose of acalabrutinib, 6 months after the last dose of endamustine, or 12 months after the last dose of rituximab, whichever is longest; Willing and able to participate in all required evaluations and procedures in this study protocol including swallowing capsules without difficulty;
Ability to understand the purpose and risks of the study and provide signed and dated informed consent and authorization to use protected health information (in accordance with national and local patient privacy regulations)"	"History of prior malignancy except for the following:
Malignancy treated with curative intent and with no evidence of active disease present for more than 2 years before screening and felt to be at low risk for recurrence by treating physician;  
Note:  Provided they meet other eligibility criteria, subjects who are receiving hormonal therapy alone are allowed to enroll on study;
Adequately treated lentigo maligna melanoma without current evidence of disease or adequately controlled nonmelanomatous skin cancer;
Adequately treated carcinoma in situ without current evidence of disease;
Subjects for whom the goal of therapy is tumor debulking before stem cell transplant;
Any history of central nervous system (CNS) lymphoma or leptomeningeal disease;
Uncontrolled autoimmune hemolytic anemia (AIHA) or idiopathic thrombocytopenic purpura (ITP);
Major surgical procedure within 28 days before first dose of study drug.  Note: If a subject had major surgery, they must have recovered adequately from any toxicity and/or complications from the 
intervention before the first dose of study drug;
Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of first dose of study drug, or any Class 3 
or 4 cardiac disease as defined by the New York Heart Association Functional Classification, or corrected QT interval (QTc) &gt; 480 msec (calculated using Friderica’s formula:  QT/RR0.33) at 
screening.  Exception: Subjects with controlled, asymptomatic atrial fibrillation during screening are allowed to enroll on study;
Absolute neutrophil count (ANC) &lt; 1.0 x 109/L or platelet count &lt; 75 x 109/L; for subjects with disease involvement in the bone marrow, ANC &lt; 0.75 x 109/L or platelet count &lt; 50 x 109/L.  Subjects will only be considered eligible if peripheral blood counts can be 
maintained independent of growth factors or transfusions during the screening period;
Total bilirubin &gt; 1.5 x upper limit of normal (ULN); or aspartate aminotransferase (AST) or 
alanine aminotransferase (ALT) &gt; 2.5 x ULN;
Estimated creatinine clearance of &lt; 50 mL/min, calculated using the formula of Cockcroft and Gault [(140-Age) • Mass (kg)/(72 • creatinine mg/dL) • multiply by 0.85 if female];
Prothrombin time/international normalized ratio (INR) or activated partial thromboplastin time (aPTT; in the absence of a Lupus anticoagulant) &gt; 2.0 x ULN; Exception:  Subjects receiving 
warfarin are excluded; however, those receiving other anticoagulant therapy who have a higher INR/aPTT may be permitted to enroll to this study after discussion
with the medical monitor;
Malabsorption syndrome, disease significantly affecting gastrointestinal function, resection of the stomach, extensive small bowel resection that is likely to affect absorption, 
symptomatic inflammatory bowel disease, partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass;
Uncontrolled active systemic fungal, bacterial, viral, or other infection (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite 
appropriate antibiotics or other treatment), or intravenous anti-infective treatment within 2 weeks before first dose of study drug;
Known history of infection with human immunodeficiency virus (HIV);
Ongoing immunosuppressive therapy, including systemic (eg, IV or oral) corticosteroids within 2 weeks before the first dose of study drug. Note: Subjects may use topical or inhaled corticosteroids or low-dose steroids as therapy for comorbid conditions. During
study participation, subjects may also receive systemic (eg, IV or oral) corticosteroids as needed for treatment-emergent comorbid conditions;
Known history of anaphylaxis or hypersensitivity to bendamustine, rituximab, or any of their 
components;
Serologic status reflecting active hepatitis B or C infection.
Subjects who are hepatitis B core antibody (anti-HBc) positive and who are surface antigen negative will need to have a negative polymerase chain reaction (PCR) result before randomization. 
Those who are hepatitis B surface antigen (HbsAg) positive or hepatitis B PCR positive will be excluded;
Subjects who are hepatitis C antibody positive will need to have a negative PCR result before randomization. Those who are hepatitis C PCR positive will be
excluded;
Received a live virus vaccination within 28 days of first dose of study drug;
History of stroke or intracranial hemorrhage within 6 months of first dose of study drug;
History of bleeding diathesis (eg, hemophilia or von Willebrand disease);
Presence of a gastrointestinal ulcer diagnosed by endoscopy within 3 months before first dose of study drug;
Requires or receiving anticoagulation with warfarin or equivalent vitamin K antagonists (eg, phenprocoumon) within 7 days of first dose of study drug;
Requires treatment with a strong cytochrome P450 3A (CYP3A) inhibitor/inducer;
Requires treatment with proton-pump inhibitors (eg, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, or pantoprazole).  Subjects receiving proton-pump inhibitors who 
switch to H2-receptor antagonists or antacids are eligible for enrollment to this study;
Concurrent participation in another therapeutic clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-9tg54c	The effect of Biodanza on people with Depression in psychosocial care centers	Recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1610	Efficacy of Biodanza in levels of Depression, Anxiety, Stress, Self-esteem and Life satisfaction in people with Depression in psychosocial care centers: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-13	Universidade Federal de Alagoas - UFAL	Universidade Federal de Alagoas - UFAL	https://ensaiosclinicos.gov.br/rg/RBR-9tg54c	<NULL>	Volunteers who are assisted in the Psychosocial Care Centers; 18 years of age or over; signs and symptoms of depression through the results of the application of the Mini International Neuropsychiatric Interview and or Beck Depression Inventory; stable and on medication for at least 12 weeks.	Volunteers in an acute stage of hallucination and dissociation; history of neurological disease affecting motor skills; recurrent epilepsy; dependence or abuse of alcohol and/or other illicit psychoactive substances; not adhere to Psychosocial Care Centers treatment during the survey period; 25% of absences in the sessions of Biodanza and in the treatment of Psychosocial Care Centers in the period of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-4rxhd4	How the Pelvic Floor Muscle influence in Posture of elderly women	Recruiting	Intervention	2018-01-31	<NULL>	<NULL>	1612	The influence of Pelvic Floor Muscle Training in Postural Control of elderly women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-06-05	UNESP, Universidade Estadual Paulista Júlio de Mesquita Filho, Câmpus de Marília - Faculdade de Filosofia e Ciências, FFC	UNESP, Universidade Estadual Paulista Júlio de Mesquita Filho, Câmpus de Marília - Faculdade de Filosofia e Ciências, FFC	https://ensaiosclinicos.gov.br/rg/RBR-4rxhd4	<NULL>	Have, at the time of the evaluation, 60 years or more; To reside in Marília, without restriction of march or use of auxiliary devices for the same one; Ability to stand for at least 90 seconds; Cognitive ability to understand and perform the tasks requested by the examiner according to the &quot;Mini-Mental State Examination&quot; (MMSE), which requires a significant level of education, with a maximum of 30 points, 18 points for illiterate elders; 21 for the elderly with 1 to 3 years of schooling, 24 points for the elderly with 4 to 7 years of schooling and 26 points for the elderly with 8 or more years of schooling. Endurance of pelvic endurance up to 3 seconds - graded by the Pelvic Floor Functional Evaluation - AFA.	Patients who do not complete the 12 meetings; Patients who give up care;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:00
RBR-592yyp	Effects of motor training in elderly clinical responses	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1614	Effects of proprioceptive training on the responses and sensorial and functional responses of elderly people with peripheral diabetic neuropathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-10	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-592yyp	<NULL>	Age at or above 60 years, insufficiently active, absence of cognitive deficit, absence of impairment due to cardiovascular diseases limiting to exercise, absence of severely impaired visual or auditory acuity, absence of cutaneous lesions in the feet and amputations, independent walking and locomotion without auxiliary devices and absence of diagnosis of neurological disease that affects gait pattern.	Elderly persons attending another proprioceptive rehabilitation program during training or in the last three months, and those who participate in less than 75% of the training program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-6cgx2k	Effect of TENS on pain relief after surgery	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1615	Effect of Transcutaneous Electrical Nerve Stimulation on postoperative pain relief	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-15	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-6cgx2k	<NULL>	Age greater than 18 years; submitted to abdominal surgery (elective or complicated cholelithiasis, choledocholithiasis, obstructive jaundice, acute pacritatitis, acute cholestasis) and cardiac surgery that are hospitalized at the Hospital de Clínicas of UFTM; With post operative pain complaint; Ability to respond to assessment; Absence of provisional or definitive pacemaker; Sign the TCLE.	• Dehiscence or infection in the surgical incision with exposure of the injured skin; Tumors; New surgery during the intervention or death period; Supra renal disease, use of corticosteroids or steroid anti-inflammatory drugs that alter or influence the dosage of cortisol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-7xds2v	Biofeedback in improving diabetic heart health.	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1616	Cardiovascular biofeedback in autonomic neuropathy in individuals with Diabetes Mellitus type 2.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7xds2v	<NULL>	The following may be included in the study: individuals with Type 2 Diabetes mellitus of both sexes; aged 50-75 years; sedentary; no history of neurological diseases; muscular or rheumatic diseases outside the etiology of diabetes and that reside in the region of Greater Recife.	The exclusion criteria applied will be: presence of unstable angina; pacemaker; severe pneumopathies or other limiting diseases such as neoplasms; valvulopathies; advanced dementia; aortic aneurysm; renal insufficiency and decompensated heart failure. Individuals with orthopedic and / or neurological diseases that may not be able to perform the cardiopulmonary exercise test will also be excluded; besides the patients who present intellectual deficiencies that restrict them to answer the questionnaires and understand the proposed games.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-5hhtrt	Efficiency of muscle training with visual support for swallowing in the elderly	Recruiting	Intervention	2018-02-01	<NULL>	<NULL>	1620	Efficiency of muscle training with electrophiographic biofeedback in elderly deguidation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-19	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5hhtrt	<NULL>	The target population will consist of robust elderly; of both genders; over 60 years old; independent, with or without chronic diseases; as long as these are under control.	subjects who do not attend for more than two sessions evaluations and the biofeedback program; as well as those who develop disease that compromises swallowing, such as: disorder of the cervical osteomyelitis system; Brain vascular accidents; Neurodegenerative diseases; Systemic arterial hypertension and diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-89x588	Effects of Treadmill walking on quality of life and 6-minute walk test of institutionalized elderly	Recruiting	Intervention	2018-02-02	<NULL>	<NULL>	1622	"Effects of a Treadmill program on quality of
life and functional capacity of
institutionalized elderly"	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-07	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-89x588	<NULL>	Elderly institutionalized residents of the city of Marília-SP; of both sexes; aged 60 years or older; with functional impairment categories (CDF) greater than or equal to 2; without cognitive deficit in the Mental State Mini Exam according to the years of schooling (BRUCKI et al., 2003)	Individuals who refuse to sign the consent form; with untreated neurological or cardiorespiratory pathologies and / or who limit the ability to walk on the treadmill; with visual or auditory deficits incapacitating to conduct the research; and the elderly who interrupt in any Stages of intervention or evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-5jz7b2	The way Dental Fluorosis is perceived by children and their relatives and the results that a new treatment promoted by a new low viscosity resin can provide to patients who have fluorosis.	Recruiting	Intervention	2018-02-02	<NULL>	<NULL>	1623	Perception of Dental Fluorosis and Resin Infiltration efficacy on its esthetic treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-16	Faculdade de Ciências da Saúde - Universidade de Brasilia	Secretaria de Educação do Governo do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-5jz7b2	<NULL>	"Presence of, at least, four anterior teeth affected by fluorosis classified as mild to moderate (2 to 5)according to Thylstrup and Fejerskov index;
Possibility of periodic return for revaluations;
Who have reported to be dissatisfied with the appearance of their teeth in the Child&apos;s and Parent&apos;s Questionnaire about Teeth Appearance"	"Presence of carious lesions on the teeth to be treated;
General and oral health that do not support clinical exam;
Dental hypersensitivity;
Presence of extensive restoration in anterior teeth that do not allow appropriate diagnosis;
Use of orthodontic appliances;
Patients with teeth affected by tetracycline stains;
Patients with anterior teeth affected by MIH;
History of allergy to any of the resin infiltrant components."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9mqzvz	Efficacy of Regenerated Oxidized Cellulose versus Calcium Alginate in Bleeding from Breast Wounds caused by Cancer	Recruiting	Intervention	2018-02-02	<NULL>	<NULL>	1624	Efficacy of Regenerated Oxidized Cellulose versus Calcium Alginate in the control of Bleeding from Malignant Wounds due to Breast Cancer: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-19	Escola de Enfermagem da Universidade de São Paulo	Hospital de Câncer III do Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA	https://ensaiosclinicos.gov.br/rg/RBR-9mqzvz	<NULL>	Be 18 or older; have breast cancer with hemorrhagic wound in one or both breasts; being in stable emotional conditions that allow participation in the intervention of the study; and accept venipuncture for blood collection.	Patients who have bleeding present in the malignant wound of the breast due to arterial cause; bleeding present in the malignant wound of the breast but without visualization of the origin of the bleeding site; patients with a known allergy to the hemostatic products used in the main study intervention, and patients who have had bleeding in their malignant breast wounds, but who have already participated in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-9gnpdp	Influence of the positioning of the electrodes on the pain relief provided by TENS	Recruiting	Intervention	2018-02-05	<NULL>	<NULL>	1629	Positioning of electrodes influence on hyporalgesia induced by TENS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-26	Fundação Universidade Federal de Sergipe	Laboratório de Pesquisa em Neurociência (LAPENE) - Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9gnpdp	<NULL>	Healthy subjects; Age 18-45 years old; Agree to participate in the study	Pain; loss or damage to the nerves of the upper and lower; pregnancy; cardiac pacemaker; allergy to carbon electrodes;use of analgesic medication or psychiatric; changed conditions of the skin or loss of sensitivity in the areas of placement of the electrodes; history of current pain or surgery in the application region of TENS.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-58jj2j	Data collection of patients with diagnostic of T-cell Lymphoma in the five regions in Brazil	Recruiting	Observational	2018-02-05	<NULL>	<NULL>	1630	T-cell Brazil Project: prospective collection of data in patients with T-cell Lymphomas distributed in the five distinct macro regions in Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Hospital Samaritano de Sao Paulo Ltda	GEMOH- Grupo de estudos multicentricos em onco-hematologia	https://ensaiosclinicos.gov.br/rg/RBR-58jj2j	<NULL>	Date of diagnosis from January, 2015, Newly diagnosed patients with T-cell or T/NK cell peripherical lymphomas; tissue biopsies adequate for diagnosis and classification, all available for centralizes review; clinical data including baseline information on disease localization and laboratory parameters at staging, features on treatment adopted and assurance of follow up updating for at least 5 years are requested. Besides that, dated and signed consent form.	If diagnosis of Blastic NK-cell leukemia/lymphoma; Aggressive NK-cell leukemia; T-cell large granular lymphocytic leukemia; T-cell large granular lymphocytic proliferation; NK-cell large granular lymphocytic proliferation; T-cell prolymphocytic leukemia; Precursor T-cell lymphoblastic leukemia/lymphoma; mycosis fungoides; sézary syndrome; primary cutaneous ALCL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-3q2c68	The inclusion of non-drug therapy in the Nursing Process for the control of nausea / vomiting and mouth sores in patients with breast and lung Cancer undergoing chemotherapy	Recruiting	Intervention	2018-02-06	<NULL>	<NULL>	1634	The inclusion of non-drug therapy in the nursing process for the management of emesis and mucositis in patients with breast and lung Cancer submitted to chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-20	Departamento de Enfermagem da Universidade Estadual de São Paulo	Universidade Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3q2c68	<NULL>	Over 18 years of age;both genders;carrier of breast or lung cancer;being in adjuvant or neoadjuvant chemotherapeutic treatment;being the first chemotherapy treatment performed;to be performing the first 4 cycles of chemotherapy in the State Hospital of Botucatu.	Patients in palliative care;patients refuse to participate in the research;who not in the first 4 cycles of chemotherapy;patient with recurrence of breast and lung cancer;withdrawal of treatment;death.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:01
RBR-775y3d	Assessment of adherence to the guidelines for the management of Obesity in patients in the line for Surgery to Reduce the Stomach	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1635	Assessment of adherence to the guidelines for self-management of Obesity in patients in the waiting line for Bariatric Surgery in SUS: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Estadual Paulista `` Julio de Mesquita Filho´´ Faculdade de Ciências Farmacêuticas, Câmpus Araraquara	Fundação Faculdade Regional de Medicina de São José do Rio Preto- FUNFARME / Hospital de Base	https://ensaiosclinicos.gov.br/rg/RBR-775y3d	<NULL>	Patients with indications for bariatric surgery; aged between 18 and 65 years.	patients that are receiving care or guidance from other services for weight loss; history of alcohol or drug abuse; inflammatory cardiovascular disease in the active phase; chronic kidney disease; active cancer; severe cardiovascular disease; chronic obstructive pulmonary disease; systemic arterial hypertension that do not use medication for control; untreated thyroid disorders; severe functional limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-9rpv92	Use of Glass Fiber Post in Teeth with Veneers	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1638	Use of Intracanal Fiber Post effect in the fracture resistance of Teeth with Veneers: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9rpv92	<NULL>	"Be at least 18 yaers old; good conditions of health; do not present periodontal desease;
-Have coronal darkeness, larger restorations affecting vestibular face; have antagonist and adjacent teeth; endodontical treatment with good conditions; patients that don&apos;t have sistemics deseases or allergy to materials used; absence of parafunctional habits; central or lateral maxillary incisors with need of aesthetical rehabilitation with direct veneers of composite resins."	Removable prosthesis which have support on tooth of study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-725bwg	Efficacy of a Pilates protocol for Non-specific Low Back Pain individuals	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	1639	Electromyographic assessment of the trunk muscles in individuals with Non-especific Low Back Pain submitted to a Pilates protocol	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-725bwg	<NULL>	Age between 18 and 40 years. Negative straight leg raise test. Presence of aberrant movement. Positive prone instability. Negative fear avoidance beliefs questionnaire (FABQ-W &lt;19).	Individuals with specific low back pain. Congenital malformation. Sensory or motor alterations. Individuals who do not fit the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-785ghf	Comparison of two medium for semen freezing with addition of some components in order to improve the quality of spermatozoa of infertile men.	Recruiting	Intervention	2018-02-14	<NULL>	<NULL>	1641	Comparison of two medium for semen cryopreservation regarding the effects of lipid supplementation and antioxidant action on sperm viability in men with altered seminal parameters: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-02-01	Faculdade de Medicina de Ribeirão Preto	Invitra	https://ensaiosclinicos.gov.br/rg/RBR-785ghf	<NULL>	Men aged 18-40 years; literate;sent to the accomplishment of the spermogram in the laboratory of Gynecology and Obstetrics; able to collect the semen by masturbation; accept to participate in the study by signing a Term of Free and Informed Consent	Semen volume smaller than or equal 1.5 ml; sperm concentration greater than 15 million / mL; progressive motility greater than 32%; azoospermia; history of cancer from any location; previous or current use of chemotherapeutics or other medications known to interfere with spermatogenesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-5684wx	The Effect of Postural Gymnastics on Flexibility and Pain Relief in Badminton Players	Recruiting	Intervention	2018-02-20	<NULL>	<NULL>	1643	The Effect of the Isostretching Method on Flexibility and Pain relief in badminton players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-05-26	Associação Teresinense de Ensino	Associação Teresinense de Ensino	https://ensaiosclinicos.gov.br/rg/RBR-5684wx	<NULL>	Players of both sexes; Athletes who have a link with the institutions where the research will be carried out and the athletes that are part of the Piauiense Badminton Federation;	Athletes who engage in some parallel physical activity or other sport; Athletes who present some articular deformity, neurological, respiratory disorder, difficulty understanding in performing the technique.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-3qp5np	Mastication and sleep features study after  electro-mechanical therapies and use of intraoral device in patients with Down syndrome: evaluation of muscles, sleep and saliva.	Recruiting	Intervention	2018-02-20	<NULL>	<NULL>	1647	Evaluation of the function of the masticatory muscles and physiologic sleep variables after therapies of electro-mechanical bioestimulation and use of intraoral device in patients with Down syndrome: electromyography, polysomnography and salivary parameters.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-18	Instituto de Ciências eTecnologia ICT - Universidade Estadual Paulista Julio de Mesquita Filho - UNESP	Instituto de Ciências eTecnologia ICT - Universidade Estadual Paulista Julio de Mesquita Filho - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3qp5np	<NULL>	"Down Syndrome patients; both genders; snoring and mild to moderate apnea/hypoapnea index;  cognitive  status parcialy preserved; understand the verbal comands necessary to perform this research project; agree to participate by free will and must sign the Awareness Term.
  
Cognitive analysis will be realized under  simple comands, such as &quot;open the mouth&quot;, &quot;close the mouth&quot;, &quot; bite&quot;, &quot;relax&quot;. If patients be able to answear this simple comands, will be considered as part of the study."	Body mass index grater than 30; unsatisfactory dental health; not able to reach the University when is needed; have been submited to physiotherapic and orthodontic treatment at least 6 months before the begining of this study; present psychiatric disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-3cj934	Effects of phototherapy on chronic low back pain	Recruiting	Intervention	2018-02-21	<NULL>	<NULL>	1649	Effects of photobiomodulation on pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-3cj934	<NULL>	It will be included volunteers of both genders; adults; aged between 20 and 65 years; body mass index (BMI) between 20 and 34.9 km/m2, who are eutrophic subjects; pre-obese or with moderate obesity (degree I). Volunteers should report complaints of low back pain for a period equal or greater than 3 months, with the same intensity, irradiated or not for their lower limbs.	It will be excluded volunteers who present lumbar cancer; coagulation disorders; infection; neurological deficits; and volunteers who use anti-inflammatory; and / or analgesic drugs during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:02
RBR-4wz3w3	Group Therapy and Self-monitored Home Exercises to increase exercise practice in the subacute phase after Stroke - Randomized Clinical Trial	Recruiting	Intervention	2018-02-23	<NULL>	<NULL>	1651	Task-oriented Group Therapy and Home-based Exercise increase in the amount of practice in the subacute phase after Stroke - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-22	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4wz3w3	<NULL>	Individuals with the following characteristics will be included: Single and unilateral stroke proven by imaging or medical report; Maximum of 6 months after brain injury (subacute phase), able to understand simple commands, evaluated through the Mini State Mental Examination (MMSE), score higher than 18 points (illiterate) and 24 points (school instruction) (LOURENÇO; , 2006); Able to maintain standing posture, with or without an auxiliary device, evaluated by the Motor Assessment Scale (MAS), item 5, with a minimum score of 3 points.	Individuals with the following characteristics will not be included: Previous stroke with residual motor deficit; Cerebellar stroke; Other neurological diseases (such as Parkinson&apos;s Disease, Herpes Zoster, among others); Associated orthopedic problems that may interfere with mobility; Uncontrolled heart problems that may restrict your participation in activities;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-6wnxv2	Impact of Shock Wave Therapy on male sexual impotence	Recruiting	Intervention	2017-04-18	<NULL>	<NULL>	1655	Impact of Low-Intensity Extracorporeal Shock Wave Therapy in the treatment of erectile dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-6wnxv2	<NULL>	Older than 18 years; confirmed and non-disabling coronary artery disease; erectile dysfunction for more than 6 months classified as mild to moderate (IIEF&gt; 15); erectile dysfunction responsive to use 5PDEi; exclusive sexual partner; preserved libido.	Patients with uncontrolled diabetes mellitus (Glycated Hemoglobin&gt; 10%); low testosterone levels; previous radical prostatectomy or other pelvic surgeries; patients with structural abnormalities of the penis; pelvic radiation history; central and peripheral neuropathies; psychiatric disorders; using anticoagulants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-3d296r	A study comparing maintenance and resection of retropatellar fat in the knee prosthesis	Recruiting	Intervention	2018-02-26	<NULL>	<NULL>	1659	Comparative study between maintenance and resection of retropatellar fat pad in total knee arthroplasty; Clinical functional evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-12	Universidade Federal de Minas Gerais	Hospital Universitario Ciencias Medicas	https://ensaiosclinicos.gov.br/rg/RBR-3d296r	<NULL>	Voluntary patients who spontaneously accept and sign the Term of Free and Informed Consent, the TCLE, after succinct explanation by the researcher; above 55 years; both sexes; patients with osteoarthrosis, primary or secondary to osteonecrosis, or vicious fracture consolidation; committed to perform the standard protocol of postoperative rehabilitation.	Voluntary patients with inflammatory joint disease; with a low preoperative patella, diagnosed radiologically by the Insall-Salvati index; with knee flexion above 15 degrees and limitation of flexion above 90 degrees, preoperatively.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-778wr4	Effects of Physical Exercises in Group and at Home for the Elderly	Recruiting	Intervention	2017-10-02	<NULL>	<NULL>	1663	Effectiveness of a Supervised and Unsupervised Exercise Program for the Elderly: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-15	Universidade do Sagrado Coração	Secretaria Municipal de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-778wr4	<NULL>	Fragile elderly; Age above 60 years; Both sexes; Any level of schooling	Severe cognitive impairment; Severe motor impairment; Severe hearing deficit; Severe vision deficit; Temporary or permanent incapacity to wander; Elderly in the terminal stage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:03
RBR-2nch7x	Effect of Different Types of Implants on the Total Mandible Rehabilitation	Recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1667	Titamax® and Helix® Implants in Protocol Procedures. A Clinical, Controlled, Randomized, Double-Blind and Multicentric Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2nch7x	<NULL>	Age between 18 and 60 years; Necessity of Lower total rehabilitation with osseointegrated implants; To present bone availability associated to the region between the mentual foramen enough for installation of a conventional implant; Presence of good systemic health; All implants should have at least 45N of insertion torque, to allow immediate loading of the implants.	Smokers and former smokers; Diabetics; Patients who use drugs or had pathologies that alter bone metabolism; Patients who use chronically anti-inflammatory and antibiotics drugs; Bruxism; Etilistis; Chemical dependents; Pregnant or wishing to become pregnant next year; History of radiotherapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-3t56dh	Evaluation of the training of physiotherapists in end-of-life care and how they apply their skills	Recruiting	Observational	2018-03-01	<NULL>	<NULL>	1668	Evaluation of the training of physiotherapists in palliative care and how they develop their professional skills	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Estadual de Campinas (Unicamp) - Faculdade de Ciências Médicas (FCM)	Universidade Estadual de Campinas (Unicamp) - Faculdade de Ciências Médicas (FCM)	https://ensaiosclinicos.gov.br/rg/RBR-3t56dh	<NULL>	Healthy volunteers; trained in physiotherapy; independent of the year of graduation; whether or not you have a postgraduate degree; both genders; age between 18 and 80 years; perform their function in a hospital environment.	Volunteers who do not agree to participate in the research; not have registered in the Regional Council of Physical Therapy and Occupational Therapy; not working in a hospital environment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-6hvjnq	Effect of acupuncture on pain and inflammatory mediators in patients with fibromyalgia	Recruiting	Intervention	2018-03-01	<NULL>	<NULL>	1669	Fibromyalgia: studies involving pathophysiological mechanisms associated with pain, inflammation and muscle damage and the potential effect of acupuncture on these processes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Santa Maria/Pro-Reitoria de Pós-Graduação	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6hvjnq	<NULL>	"Women;
Age between 20 and 60 years old;
Diagnosis of fibromyalgia according to the American College of Rheumatology criteria."	"Severe psychiatric illness;
With neurological or sensory deficit;
Patients who have contraindications to acupuncture;
Pregnant women;
Lactating;
Patients unable to attend the acupuncture sessions;
Patients who do not accept the conditions proposed in the term of free and informed consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-9w7vxd	Effect of wheelchair basketball for people with disabilities on thermogenesis	Recruiting	Intervention	2018-03-02	<NULL>	<NULL>	1671	Wheelchair basketball for people with disabilities in Mato Grosso: thermogenesis, health, sports, accessibility and quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-09	Hospital Universitário Júlio Müller da Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso-UFMT	https://ensaiosclinicos.gov.br/rg/RBR-9w7vxd	<NULL>	"voluntary gender male of the 18-60 years old, non smokers, with good capacity of upper limbs is preserved. Good intellectual understanding
Sign the informed consent form (SICF).
With medical certificate for sports practice assessing their clinical state of health for the sport of the research."	People with disabilities without sporting ability or affinities with sport. Time less than 18 months of injury. With lesions above C7, severe one cruve or two curve scolios with greater Cobbi angles 35 graus. with unstable osteometallic fixation. Weight within the variation limit of 15% of the weight considered normal for men and women, taking into account height and physical structure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4qn7t8	Observational study of spermogram normal values  of the Brazilian population	Recruiting	Observational	2018-03-02	<NULL>	<NULL>	1672	The seminal profile of the Brazilian population	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Sociedade Brasileira de Urologia	Sociedade Brasileira de Urologia	https://ensaiosclinicos.gov.br/rg/RBR-4qn7t8	<NULL>	"Participants in the study will seek urology clinics and sign the Informed Consent Term, in agreement with the methodology proposed in this study. Seminal samples of 692 patients aged 20 to 49 years from all regions of Brazil will be evaluated, following the following distribution, according to the demographic distribution of the Brazilian population described by CENSO 2010; Statistics applied to social sciences:
North Region (8.2%): 57
Northeast Region (26.8%): 185
Central West Region (7.8%): 54
Southeast Region (42.8%): 296
South Region (14.4%): 100
Samples will be obtained by masturbation, after three to five days of ejaculatory abstinence, collected in a sterile plastic bottle and immediately sent to the andrology laboratory."	Samples collected outside the proposed ejaculatory withdrawal window or under non-sterile conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-27fpmt	Comparison of the efficacy and safety of surgical laser with electrocautery in the treatment of gingiva increase by denture	Recruiting	Intervention	2018-03-02	<NULL>	<NULL>	1673	Comparison of the efficacy and safety of diode surgical laser with electrocautery in the treatment of inflammatory fibrous hyperplasia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-02	Universidade federal de Minas Gerais	Universidade federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-27fpmt	<NULL>	Healthy volunteers; age greater than 18 years; both genders; with clinical diagnosis inflammatory fibrous hyperplasia.	Volunteers using analgesic medication; with systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-3pmndt	Influence of Therapeutic Exercise on the balance, strength and functionality of the Elderly	Recruiting	Intervention	2018-03-08	<NULL>	<NULL>	1679	Influence of Kinesiotherapy on variables of postural control and validation of an instrument for evaluation of isokinetic strength in the Elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3pmndt	<NULL>	Individuals 60 years of age or older; able to practice the proposed activities and evaluations; availability to participate in activities twice a week; absence of medical contraindications to the exercises; signing of the Term of Free Consent and Enlightened.	Inability to maintain standing and gait posture; which is necessary for the performance of the tests; with neurological disorders; urinary or fecal incontinence, renal insufficiency; infectious diseases, use of probes; vascular thrombus or heart failure; individuals With uncontrolled blood pressure; minimal exertion dyspnea, dementia; participation in 80% of the treatment; participation in another program of physical activity and physiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-4xyyn6	The effects of comfrey in subjects with Neuropathic Ulcers for Diabetes	Recruiting	Intervention	2018-03-08	<NULL>	<NULL>	1680	Effects of external use of Comfrey on Neuropathic Ulcers for Diabetes at the stomatherapy ambulatory of the hospital of education of the quaternary public network	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital Geral de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-4xyyn6	<NULL>	Volunteers with neuropathic ulcer due to diabetes accompanied at the General Hospital of Fortaleza; both genders; non smokers; age above 18 years;	Volunteer smokers; Diagnosis of cancer; Diagnosis of hepatic pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:04
RBR-6mk5n4	Study to evaluate the efficacy and safety of treatment of Cutaneous Leishmaniasis with Meglumine Antimonate applied directly to the lesion or Intramuscularly / Intravenously in several states of Brazil	Recruiting	Intervention	2018-03-08	<NULL>	<NULL>	1681	Multicenter study evaluating the efficacy and safety of Intralesional administration of Meglumine Antimoniate compared to Systemic treatment for Cutaneous Leishmaniasis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2017-12-01	Instituto Nacional de Infectologia Evandro Chagas (INI) -Fiocruz	Instituto Nacional de Infectologia Evandro Chagas (INI) -Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-6mk5n4	<NULL>	"Inclusion criteria 
Patients who are able to sign the informed consent and willing to participate in the study as subjects attending the follow-up visits as foreseen by the study schedule;
Patients who present up to a maximum of three lesions with or without ulceration;
Patients with confirmed parasitic infection by Leishmania by scraping or imprint or histopathological examination or culture or immunohistochemistry or by polymerase chain reaction;
Patients who present lesions with a maximum of 5 cm in diameter for a single lesion or up to 3 cm for two lesions or up to 2 cm  in the case of three lesions;"	"Women of childbearing age who do not use contraceptive methods or do so improperly;
Pregnant Women;
Children under the age of 13;
Patients with lesions in the cephalic segment;
Patients who have had previous treatment with MA;
Patients with disseminated or diffuse or recidiva cutis leishmaniasis;
Patients with of any form of leishmaniasis with mucous membrane involvement;
Patients with concomitant use of any medication with recognized toxic interactions with Sb5+ which cannot be substituted over the study period;
Patients with comorbid conditions such as heart or kidney or liver diseases."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-344jq8	Assessment of applicability and results of nerve electrical stimulation in the treatment of children with intractable intestinal constipation	Recruiting	Intervention	2018-03-13	<NULL>	<NULL>	1685	Evaluation of applicability and clinical outcomes transcutaneous electrical nerve stimulation posterior treatment of children with constipation intractable intestinal	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina de Botucatu-FMB/UNESP	Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina de Botucatu-FMB/UNESP	https://ensaiosclinicos.gov.br/rg/RBR-344jq8	<NULL>	Patients between the ages of 7 and 18 years of age, of both sexes, with a diagnosis of CIC, established according to the criteria of Rome IV, and classified as having intractable intestinal constipation, according to the definition of the European Societies ( ESPGHAN) and North American (NASPGHAN) Gastropediatrics, represented by patients unresponsive to standard treatment, after a period of threE months	"Patients whose parents and / or guardians do not agree to participate in the study and who do not sign the Free and Informed Consent Term, as well as patients between the ages of 12 and 18 who do not sign their consent form, will be excluded. Patients with any identifiable organic cause for intestinal constipation will be excluded from the study. Exclusion criteria will also be considered: neurological and / or cognitive deficits, skin lesions in the region of application of electrodes, changes in local sensitivity, presence of cardiac pacemaker, children presenting with cardiac arrhythmias or cardiac arrhythmias, patients presenting incomplete questionnaires or that are subject to drug changes and the standard
during the intervention period or who abandon the proposed electrostimulation treatment during the intervention period"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-4n4c4z	Correction of umbilical hernia with anterior muscle tissue compared to posterior muscular tissue	Recruiting	Intervention	2018-03-27	<NULL>	<NULL>	1690	Umbilical herniaplasty onlay versus sublay	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Hospital Presidente Vargas	Hospital Presidente Vargas	https://ensaiosclinicos.gov.br/rg/RBR-4n4c4z	<NULL>	Female patients; 18 years of age or older; presenting with primary umbilical hernia.	Patients with relapsed umbilical hernia; need for another concomitant surgical procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-736xwr	Stomach Reduction with Interposition of the Small Intestine for the Treatment of Type 2 Diabetes Mellitus	Recruiting	Intervention	2018-03-27	<NULL>	<NULL>	1691	Ileal interposition associated to a  sleeve gastrectomy  for the treatment of type 2 Diabetes Mellitus	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-21	Hospital Federal de Bonsucesso	Hospital Federal de Bonsucesso	https://ensaiosclinicos.gov.br/rg/RBR-736xwr	<NULL>	Documented diagnosis of type 2 diabetes mellitus; Patients of both sexes treated with oral antidiabetic agents and / or insulins; Stable antidiabetic medication in the last 8 weeks prior to selection, if the therapy includes insulin, the mean daily dose should not have been changed by more than 10% in the last 8 weeks; HbA1c&gt; 7.0%; Age&gt; 20 years and &lt;65 years;Body mass index (BMI) of 25 to 35 kg / m²; Agree to sign the TCLE;	Diabetes mellitus type 1 (anti-GAD positive) or anti-GAD negative body with low ?-cell function (peptide C after stimulation &lt;0.5 ng / ml); Recent vascular event (myocardial infarction, coronary angioplasty or encephalic vascular accident in the last 6 months); Malignant neoplasm; Portal hypertension; Difficulty to cooperate with segment; Low ability to understand surgery; Unrealistic expectations of results; Cognitive deficit; Current pregnancy; Moderate or severe mood disorder; severe anxiety; eating disorders (based on DSM-V criteria); Chemical dependence or alcoholism (based on DSM-V criteria).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:05
RBR-6cn5t7	Study of the Biofilm of Total Dentures Fixed by Dental Implants	Recruiting	Observational	2018-03-14	<NULL>	<NULL>	1693	Clinical study of the Biofilm of Fixed Total Implanted Prostheses	<NULL>	0, n/a, n/a	0	<NULL>	<NULL>	<NULL>	2018-02-15	Departamento de Clínica Odontológica da Universidade Federal do Ceará	Departamento de Clínica Odontológica da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6cn5t7	<NULL>	The inclusion criteria for the selection of the patients are: adults; any genus; fully edentulous in the mandibular arch; with good general health; users of definitive prosthesis type made with base and artificial teeth of acrylic resin with a minimum of 6 months of last maintenance.	Exclusion criteria will be: use of antibiotics in the last 3 months; diabetes; problems associated with immunosuppression; xerostomia; motor or cognitive problems; fracture or repair in the base of the prosthesis and loose teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-9k66x6	Comparing the use of Everolimus and Tacrolimus reduced dose versus Mycophenolate Sodium and Tacrolimus reduced dose in Liver Transplant patients	Recruiting	Intervention	2018-04-01	<NULL>	<NULL>	1695	Everolimo in combination with Tacrolimus low doses versus Mycophenolate Sodium gastro-resistant coated tablets with low doses of Tacrolimus in Liver Transplant recipients “de novo”	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-14	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-9k66x6	<NULL>	Orthotopic whole organ liver transplant recipients; deceased donor; age above 18 years; both sexes; with graft functionality within 72h of reperfusion.	Patients with pre-transplant protein and urinary creatinine ratio greater than 1mg / g or proteinuria 24h greater than 1g; multiple organ transplant recipients; patients with hypercholesterolemia (greater than 350 mg / dL) or hypertriglyceridemia (greater than 500 mg / dL) severe if use of lipid-lowering therapy with controlled hyperlipidemia will be accepted; previously transplanted liver patients who progressed with graft loss and in need of retransplantation; patients with positive serology for HIV; women who are pregnant, who are planning to become pregnant, are pregnant or breastfeeding, or do not agree to use effective methods of contraception; patients with difficult decision making who are not judged medically or mentally capable of providing informed consent on their own.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-22rnjh	Effects of strength exercises on postoperative knee rehabilitation	Recruiting	Intervention	2018-04-10	<NULL>	<NULL>	1700	Effectiveness of unilateral resistance training in the postoperative rehabilitation of contralateral ACL	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-31	Universidade Federal de São Paulo / Escola Paulista de Medicina	Instituto de Pesquisa e Ensino do Hospital HOME	https://ensaiosclinicos.gov.br/rg/RBR-22rnjh	<NULL>	Will be included in the study patients of both genders, with different occupations, who practice physical activity at a recreational level, suffered the traumatic injury of the ACL and were submitted to primary reconstruction surgery using contralateral LP grafting (technique in which the graft of the limb opposite the injured). In order for the age group with the highest prevalence of lesions in the ACL (LARSON, 1994) to be respected, in addition to the exclusion of minors, everyone must be aged between 15 and 45 years.	Patients with a history of lesions and / or surgery in the knees prior to or after the injury that generated the clinical picture studied, and those who did not complete all stages of the study, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-9tn862	Evaluation of consumption of high caloric Infant Formula after surgery of Heart Defects	Recruiting	Intervention	2018-04-11	<NULL>	<NULL>	1704	Evaluation of Energy-enriched Formula consumption on Congenital Heart Disease postoperative	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-03-06	Hospital da Criança Santo Antônio	Danone LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9tn862	<NULL>	Two years old or less; both genders; undergoing heart surgery	Exclusive breastfeeding; Chylothorax	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-364qy7	The effect of Antenatal Group about Breastfeeding in Adolescent Mothers	Recruiting	Intervention	2018-04-12	<NULL>	<NULL>	1708	Influence of Antenatal Education of Maternal Breastfeeding in Adolescent: non-randomized clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-07	Faculdade de Medicina da Universidade Estadual de Campinas	Faculdade de Medicina da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-364qy7	<NULL>	Adolescents up to 19 years; primiparous; single gestation; live and term children.	Puerperas with needs for admission to the Intensive Care Unit (ICU) in the immediate postpartum period; Puerperas of newborns with diagnosis of malformation, especially orofacial; Serum positive for human immunodeficiency virus (HIV); Puerperas using drugs incompatible with breastfeeding; Puerperas with diagnosed psychiatric disorder and those with hearing or cognitive impairment that prevent interaction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:06
RBR-7t6nzr	Effects of laser and physical exercise program in patients with knee arthritis	Recruiting	Intervention	2018-04-13	<NULL>	<NULL>	1709	Phototherapy and physical exercise program in patients with knee osteoarthritis: controlled, randomized and triple blinded study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-7t6nzr	<NULL>	Grade II or III of knee osteoarthritis; female subjects; classified as low active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version; age between 55 and 70 years; willingness to participate in the treatment plan.	They have cardiovascular, neurological or musculoskeletal disease that makes them unable to perform the exercise protocol; evidence of secondary, inflammatory or metabolic disease; use of conventional, non-conventional or alternative treatments that may potentially have effects on the results of the study (physiotherapy and / or injections of intra-articular corticosteroid or hyaluronic acid during the last 3 months); symptomatic hip OA; absolute contraindication for laser therapy as the presence of neoplasia in the region of lower limbs; individuals who have malnutrition or morbid obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-9r2gpb	Pain evaluation during arterial puncture: use of local anesthetic (EMLA), oral glucose solution and acetaminophen in premature newborns	Recruiting	Intervention	2018-04-13	<NULL>	<NULL>	1711	Pain evaluation during arterial puncture: use of eutectic mixture of local anesthetic (lidocaine and prilocaine), oral glucose solution and acetaminophen (acetaminophen) in premature newborns	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Escola de enfermagem da Universidade Federal de Minas Gerais	Hospital das clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9r2gpb	<NULL>	Gestational age above or equal to thirty weeks and less than thirty-five weeks; weight higher than 1500 grams; being admited in the Neonatal Intensive Care Unit of Hospital das Clínicas of Federal University of Minas Gerais; clinical indication of blood collection trough arterial puncture; newborns in the first two weeks of life; minimum enteral diet of sixty mL/Kg per day; parents or guardians signature on the Informed Consent Form and on the image use authorization term.	Clinical diagnosis of neuromuscular dysfunction;Use of analgesia and / or bolus sedation or continuous infusion in the last 48 hours before the procedure;Newborns born to mothers who use illicit drugs;Diagnosis of necrotizing enterocolitis;Newborns under mechanical ventilation;Presence of skin lesion at puncture sites;Treatment with agents that induce methemoglobinemia such as sulfonamides, acetaminophen, phenobarbital, phenytoin and nitric oxide;Patients with hepatic impairment or bleeding;Patients with hemodynamic instabilityNeed of puncture in different places of the place previously selected for application of topical anesthetic;Need for more than three puncture attempts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-7sktsv	Longevity of Ceramic Restorations for posterior teeth.	Recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1716	Longevity of Zirconia singles crowns: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-05	Faculdade de Odontologia da Universidade Federal de Pelotas	Faculdade Meridional (IMED)	https://ensaiosclinicos.gov.br/rg/RBR-7sktsv	<NULL>	Presence of one or more endodontically treated teeth ou vital-teeth requiring a single crown as final restoration	Teeth with periodontal or endodontic problems, teeth used as abutment of fixed prosthesis and patients with health problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-5n9934	The effect of Atrial Acupuncture and Hydrotherapy on body changes in people with Type 2 Diabetes Mellitus	Recruiting	Intervention	2018-04-17	<NULL>	<NULL>	1717	The effect of Atrial Acupuncture and Aquatic Therapy on systemic and peripheral changes in people with Type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Alfenas - UNIFAL	Universidade Federal de Alfenas - UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-5n9934	<NULL>	"Age above 18 years; be a carrier of DM2 with a diagnosis of at least five years; have availability of time for submission to the intervention sessions and who agree to participate in the study by means of the 
Free and Informed Consent Form."	Possess infection; inflammation or injury to the ear patch; make use of piercing, except normal earring; total or partial amputation or presence of lower limb injury; thrombosis in the lower limbs; neurological sequelae.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-4mrftz	Analysis of small and conventional implants in the Maxilla.	Recruiting	Intervention	2018-04-18	<NULL>	<NULL>	1723	Analysis of extra-short and conventional implants in the posterior region of Maxilla.  splint-mounth randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4mrftz	<NULL>	Similar degree of atrophy in bilateral posterior maxilla region with a minimum subantral bone height of 4.0 mm and a width of 6.0 mm.	"General contraindications to surgeries with dental implants; Patient submitted to irradiation in head and neck region; Patients immunosuppressive and immunosuppression; Treated or being treated with anti-resorptive medicinal products or alter bone metabolism; Untreated periodontitis; Poor oral and low hygiene motivation; Pregnancy or Infant; Diabetes uncontrolled; Psychiatric problems or
unrealistic expectations regarding treatment; Substance abuse; Lack of dentition opposite the area intended to receive the implants; Extraction sites (Less than 3 months after extraction); Smoking."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:07
RBR-5c3x6z	The use of Swiss Ball and the acceleration of labour: a randomized study	Recruiting	Intervention	2018-04-20	<NULL>	<NULL>	1728	The use of Swiss Ball and the duration of labour active face:  a randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-5c3x6z	<NULL>	"Be primiparous, meaning that is giving birth for the first time and who choose natural labour (vaginal route), which will be allocated in an experimental or control group according to randomization;
Be secundiparous, meaning that is giving birth for the second time vaginally, having their first birth being vaginal also, to be allocated in an experimental or control group according to randomization;
Being in the active phase of labour, meaning two to three efficient uterine contractions in the minutes and cervical dilatation of 4 cm;
Bag of waters with integrity;
Gestational age between 37 to 41 weeks and six days, calculated by last menstrual period and / or the result of early ultrasound (up to 20 weeks);
Gestation with a single fetus alive in cephalic presentation. Fetal position will not be initially evaluated in this study, therefore, at the 4 cm of dilation is not possible to determine if the fetus is flexed or deflected."	It will be excluded women that present: caesarean section indication at admission; clinical or obstetric complications to justify performing the caesarean section; parturient with fetal without vitality;  women that in vaginal touch, during the subsequent evaluations, deflected fetal position; Use of uterotonic drugs; use of analgesia during labour and referral to another hospital.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-55smwr	Evaluation and treatment of pain in the shoulder after Stroke by game ShoulderForce	Recruiting	Intervention	2016-09-29	<NULL>	<NULL>	1731	Evaluation and treatment of Painful Shoulder Syndrome after Stroke by exergame ShoulderForce	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-09-22	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-55smwr	<NULL>	Individuals diagnosed with stroke in chronic phase; both genders; aged between 40 and 80; presenting the painful shoulder syndrome; spasticity less than two in Ashworth scale; voluntary movement of flexion and abduction	Individuals in the acute phase; displaying a neurological pathologies associated and / or other painful shoulder condition that is not related to post-stroke event; spasticity greater than two of Ashoworth scale; cognitive changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-2fjqvn	Evaluation of the incidence of facial nerve dysfunction after surgeries of benign parotid gland tumors performed with or without facial nerve monitoring using continuous electromyography during surgery	Recruiting	Intervention	2018-04-27	<NULL>	<NULL>	1734	Intraoperative facial nerve monitoring during superficial parotidectomy for benign parotid neoplasms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-01	Faculdade de Ciências Médicas da Unversidade Estadual de Campinas	Faculdade de Ciências Médicas da Unversidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2fjqvn	<NULL>	Adult patients with parotid neoplasms treated with superficial parotidectomy	"Neoplasms located in the deep lobe of the parotid
Malignant neoplasms requiring total parotidectomy
Previous parotid surgery
Facial nerve dysfunction prior to the surgery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-8r6xtc	Martial Arts Training combined with Multidisciplinary Interventions in Overweight and Obese adolescents	Recruiting	Intervention	2018-04-28	<NULL>	<NULL>	1735	Effect of Martial Arts Training using Karate Strokes combined with Multidisciplinary Interventions in Overweight and Obese adolescents: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-07	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8r6xtc	<NULL>	Adolescents of both sexes; with ages between 12 years and 18 years incomplete; who have the capacity to understand the questionnaires; to sign the Terms of Free and Informed Consent; that they deliver the Term of Free and Informed Consent signed by the legal representatives; who are in pubertal stage three, four or five; which has a BMI greater than one standard deviation above the median BMI according to the WHO growth reference table for each age; who has not performed regular physical exercises in the last 3 months that will precede the start of the research; who have the physical conditions to perform regular physical exercises; who is willing to attend interventions; who has never had drug treatment for weight loss; that does not make chronic use of alcohol.	Adolescents with a history of alcohol or drug abuse; who have diseases that limit exercise or put their physical integrity at risk, such as cardiovascular diseases, osteoarticular diseases, type I diabetes, renal failure, endocrine diseases and metabolic complications such as hyperinsulinemia and hypercholesterolemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-35h4xg	Female pelvic floor muscle training in the urinary symptoms of Urinary Incontinence	Recruiting	Intervention	2018-04-30	<NULL>	<NULL>	1738	Female pelvic floor muscle training in the urinary symptoms of Stress Urinary Incontinence and Mixed Urinary Incontinence	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-08-03	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35h4xg	<NULL>	Women aged 18 years old and older with symptoms of stress urinary incontinence or mixed urinary incontinence identified by the following investigation: non-zero scores for the International Consultation on Incontinence Questionnaire Overactive Bladder, validated in Portuguese language by Pereira et al., (2010); positive response to one or more of the bold options referring to question 6 of the validated questionnaire for the Portuguese language: International Consultation on Incontinence Questionnaire – Urinary Incontinence Short Form (ICIQ-UI SF), validated in Portuguese language by Tamanini et al., (2004)	Women with &quot;Pure&quot; Hyperactive Bladder Syndrome and do not present symptoms of associated stress urinary incontinence; women who have never had sexual intercourse because of the impossibility of participating in the pelvic floor muscles evaluation; those with no contractility of the pelvic floor muscles identified by vaginal palpation (grade zero, according to the Oxford Modified Scale); those with urogenital prolapse equal to or greater than three and apical prolapse (uterus or vaginal dome), assessed by Pelvic Organ Prolapse Quantification (POP-Q); those with Body Mass Index (BMI)&gt; 30, due to interference caused by body fat in the electromyography exam; carriers of myopathies and diseases with recognized alteration of collagen; carriers of neurological abnormalities, cognitive disorders, physical limitations that preclude participation in the study; those who perform or have already performed physiotherapeutic and / or surgical interventions for the treatment of pelvic floor dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:08
RBR-8jpw57	Evaluation of nutritional and clinical parameters associated with Mortality in patients at pediatric ICU: MaSCI-kids study	Recruiting	Observational	2018-04-30	<NULL>	<NULL>	1743	"Evaluation of nutritional and clinical parameters predictive of Mortality in critically ill children: multicenter cohort study MaSCI-kids (malnutrition risk
screening for critically ill kids)"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8jpw57	<NULL>	Children and adolescents of both sexes; Aged between one month and 17 years of age; Were admitted to the participating PICUs for a maximum of 72 hours.	Children and adolescents who progress with discharge or death during the first 72 hours of hospitalization; Who are in palliative care or are participating in a nutritional intervention study; Readmissions in the PICU; And premature infants who are less than one month old at the time of admission, after calculation of the corrected age.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-57gtfg	Evaluation of the use of nasal cannula after the correction surgery of facial discrepancies: passage of air and patient&apos;s discomfort	Recruiting	Intervention	2018-05-01	<NULL>	<NULL>	1745	Evaluation of the Nasal Cannula after Orthognathic Surgery: Nasal Airway Permeability and Patient Discomfort	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-20	Hospital de Reabilitação de Anomalias Craniofaciais	Hospital de Reabilitação de Anomalias Craniofaciais	https://ensaiosclinicos.gov.br/rg/RBR-57gtfg	<NULL>	"In this study, 30 patients with repaired cleft palate and / or lip submitted to orthognathic surgery with Le Fort I type osteotomy and bilateral mandibular sagittal osteotomy performed by a single mandibular maxillofacial surgeon from the Hospital for the Rehabilitation of Anomalies Craniofacial of the University of São Paulo (HRAC / USP) of Bauru-SP.
Age between 18 and 45 years."	"Present cognitive deficit according to medical records;
To present important intraoperative events in the intraoperative period and the first 24 postoperative hours, such as:
Bleeding;
Duration of surgery beyond 3 hours;
Unwanted jaw fracture;
Airway of difficult intubation (malampat 4, short neck, severe jaw deficiency, deficiency in cervical extension and difficulty in visual access of epiglottis in intubation);
Selective intubation;
Pulmonary problems due to intubation (pulmonary auscultation suggestive of atelectasis and barotraumas)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-73c67m	Effects of a physical training with video game and food supplementation with protein on muscle mass and balance in pre-frail older people	Recruiting	Intervention	2017-01-02	<NULL>	<NULL>	1748	Effects of physical training program with virtual games and protein supplementation (WiiProtein) on musculoskeletal function and the risk of falls in pre-frail older people.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-01-16	Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-73c67m	<NULL>	Both sexes; aged 65 years or over; to present itself as pre-fragile; not presenting with an acute disease or terminal illness; no metabolic instability or decompensated cardiovascular disease; do not present untreated thyroid disease; not having type I diabetes; be carriers of controlled type II diabetes, provided they present values ??of glycated hemoglobin between 8-9%; do not use medications that may affect muscle metabolism such as corticosteroids and hormones; not making use of nutritional supplement (caloric-protein); present adequate renal function (GFR&gt;60mL/min); did not present cognitive alterations according to the Mini Mental State Examination; do not present significant cognitive disturbances (vision/hearing) that prevent the understanding/execution of the evaluations and protocol of proposed exercises; to have independent gait for an 8-meter flat course, with or without assisted equipment; and functionality in the lower limbs evaluated by the Lequesne Algofunctional Questionnaire for the hip and knee joint with a score of less than or equal to 7 points for each joint separately by the Foot and Ankle Outcome Questionnaire - FAOS score above 75 points; not presenting neurological and/or orthopedic diseases with fixation or prostheses with metallic or non-metallic implants that prevent the performance of the evaluations and/or exercises proposed; osteoporosis with no history of previous fractures; the patient was not suffering from severe deficiencies diagnosed and described in the chart: cardiac, respiratory, hepatic and decompensated arterial hypertension. Have no previous history of fractures in the lower limbs and spine that prevents the full realization of the evaluations and exercises proposed for this study; not to use drugs that affect the balance; do not present any type of intolerance/allergy to milk protein; no visual impairment assessed by the Snellen card, and if participants exhibit borderline visual acuity (e.g.: one eye with 20/70 and the other presenting a single error reading the same line), it will be considered as a visual impairment, and it is considered acceptable to include in the study, in the case of presenting some visual function deficiency, to use the correction through the use of glasses or lenses	Elderly who report pain in any body region or other region that limits the evaluation and/or execution of physical training exercises; With diagnosis of neurological and/or orthopedic diseases with fixation or prosthesis with metallic or nonmetallic implants, cardiac, respiratory, renal, hepatic, diabetes, endocrine and decompensated hypertension; and elderly people not available to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-44g8vn	Comparison of the effect of Cicloergometro and physiotherapeutic exercises in patients with Chronic Renal Disease under treatment	Recruiting	Intervention	2018-05-03	<NULL>	<NULL>	1750	Comparison of the effect of Cicloergometry and Conventional Physiotherapy in patients with Chronic Renal Disease in Dialytic Treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-12	Universidade Federal de Alfenas UNIFAL-MG	Hospital Casa de Caridade Alfenas Nossa Senhora do Perpétuo Socorro	https://ensaiosclinicos.gov.br/rg/RBR-44g8vn	<NULL>	"Inclusion criteria: both genders; individuals within the age group
20 to 70 years; patients from the Hospital Casa de Caridade Alfenas Nossa Senhora do Perpétuo Socorro, Hemodialysis (HD) sector, submitted to HD three times a week."	Exclusion criteria: hemodynamic instability; pathological fractures; cognitive deficit or incoordination to run the apparatus used; Diabetes Mellitus and Systemic Arterial Hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-9c4jxp	Proposal of treatment systematization for Benign Bone Tumors comparing different techniques in different forms of presentation	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1751	Systematization proposal for the treatment of Bone Defects created after Curettage of Benign Bone Tumors	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-24	Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão	https://ensaiosclinicos.gov.br/rg/RBR-9c4jxp	<NULL>	Patients of any age and sex will be included; with benign bone tumors B2 and B3 according to the classification of Enneking; located in the long bones of upper or lower limbs and that require surgical treatment by curettage. Curettage indication consists of impending fracture; pain and size increase or progression of the lesion.	Patients with complete pathological fracture with deviation; multiple lesions that compromise the patient&apos;s function; systemic bone diseases; metadiaphyseal defects accessed through small windows smaller than 1/8 of the perimeter; proximal femur metadiaphyseal lesions with medial cortex (calcar) discontinuity in less than 30 years old patients or who refuses to participate in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-77sbfp	Clinical evaluation and digital monitoring of patients submitted to Home Dental Bleaching	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1752	Randomized clinical evaluation and digital Monitoring of patients submitted to Home Dental Bleaching: Effect of wear-time of dental bleaching on the degrees of Collaboration and patient Catisfaction, on the Effectiveness and occurrence of Sensitivity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-31	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-77sbfp	<NULL>	Absence of caries injury; Absence of defective or fractured restorations; Absence of periodontal diseases; Good systemic condition; Healthy oral soft tissues; No historical adverse reaction station to peroxides; teeth with a minimum of A2; Absence of dental elements with spontaneous pain; Absence of non-carious cervical lesions and of dentinal tissue exposed in the incisal regions.	Restorations in the vestibular of the central, lateral and canine incisors; Teeth with orthodontic appliances fixed or containing resinous residues after their removal; Pregnant or breastfeeding; Smokers and Patients who routinely use alcohol; Have previously had bleaching treatment; Teeth with fluorosis enamel stains and without pulp;  Patients with bruxism habits and those who experienced dental sensitivity prior to the experiment; Did not accept the search consent form; Unavailability of time and commitment to research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-6tjmw3	An Electronic Program to help people decide if they want to quit smoking	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1757	An Electronic Program to help people make the decision to quit smoking	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-09-04	Fundação Amparo a Pesquisa do Estado de Minas Gerais	Fundação Instituto Mineiro de Ensino e Pesquisa em Nefrologia	https://ensaiosclinicos.gov.br/rg/RBR-6tjmw3	<NULL>	Adult smokers undergoing treatment State Center for Specialized Attention of Juiz de Fora and who sign the free and informed consent form.	Smoker users who, at any time, request the cancellation of the signed free informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-84hbf5	Comparing the effect of Ibuprofen use and laser therapy on pain that occurs after canal treatment	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1759	Comparison of the effect of the use of Ibuprofen and the Photobiomodulation therapy on the postoperative pain in Endodontics: a controlled and randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-84hbf5	<NULL>	adult patients who already have indications for endodontic treatment in lower molar permanent teeth; Diagnosed with irreversible pulpitis; Have a contact phone number	Pregnant patients; Use of analgesic medication before treatment; Immunocompromised patients; Hypersensitivity to anti-inflammatories; Teeth with endodontic complications; Teeth unable to be treated in a single session; Patients unable to receive a call	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:09
RBR-69ynnw	Effect of acupuncture with needles on the physical and psychological and emotional aspects of patients with problems in the articulation of the jaw.	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1760	Effect of Auriculotherapy on the physical and psycho-emotional aspects of patients with myofascial temporomandibular disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-03-04	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-69ynnw	<NULL>	Adult volunteers aged 18 years or over; score equal to or greater than 3 in the Triage Questionnaire of the American Academy of Orofacial Pain; with the presence of myofascial pain according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC / TMD).	Volunteers with non-painful temporomandibular disorder according to RDC / TMD; patients with associated diseases: fibromyalgia, facial paralysis, rheumatoid arthritis, mental illness or cognitive deficits that would impede the understanding of some of the stages of the research; pregnant women; with external ear injuries or with immunodepression; carriers of clotting disorders, metabolic, vascular or neoplastic diseases; volunteers submitted to other types of associated therapies - interocclusal apparatus, psychotherapy, physiotherapy, orthodontics, alternative therapies; volunteers who use continuous medication (analgesics, anti-inflammatories, muscle relaxants, antidepressants / anxiolytics, anticonvulsants).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-43gmqn	Evaluation of the effects of protein supplementation on postmeal plasma glucose in adults with type 1 diabetes mellitus	Recruiting	Intervention	2018-05-04	<NULL>	<NULL>	1761	Evaluation of the effects of supplementation of protein module in late prandial glycemia in adults with Diabetes Mellitus type 1	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-05	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-43gmqn	<NULL>	Patients with Diabetes mellitus type 1, according to the diagnostic criteria presented by the Guideline of the Brazilian Society of Diabetes, of both sexes; with ages ranging from 18 to 60 years; Body mass index (BMI) within the eutrophic and overweight parameters (between 18.5 kg / m² and 30 kg / m²), according to World Health Organization (WHO) classification criteria and that agree to the Free and Clarified Consent.	Patients with a glycosylated hemoglobin (HBA1C) test of the last 3 months greater than 9%; pregnant women; patients diagnosed with renal, hepatic and or thyroid pathologies and microalbuminuria present.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-2tdtct	Electromyography evaluaton of the diaphragm muscle in patients who underwent abdominal surgery in an ICU	Recruiting	Intervention	2018-05-07	<NULL>	<NULL>	1765	Electromyographic evaluation of the diaphragm muscle in patients submitted to high abdominal surgeries with Chevron type incision in intensive care unit	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Hospital de Clínicas da Universidade Estadual de Campinas	Hospital de Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2tdtct	<NULL>	Patients post surgical intervention in the upper abdomen; with Chevron incision as liver transplantation; gatroduodenopancreatectomy and hepatectomies; who will be admitted to the unit still requiring ventilatory support for tracheal orothraqueal tube and mechanical ventilation, both genres and ages between 18 and 70 years	Patients aged less than 18 years or over 70 years; who die in surgical center; who enter an already extubated  in ICU; liver transplant recipients who undergo a new transplant, and those who do not sign the agreement term for some reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-83pwm3	The effect of the aerobic exercise associated to the upper extremity therapy in  individuals after stroke	Recruiting	Intervention	2018-05-07	<NULL>	<NULL>	1766	The effect of the aerobic exercise associated to the constraint-induced movement therapy in chronic hemiparetic individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-03	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-83pwm3	<NULL>	Chronic Hemiparetic individuals (more than 6 months) what the vascular accident involved the same hemisphere with lesions restricted to the middle and anterior vascular, report of the imaging test; 18 and 80 years; present a minimum active movement of 45° of shoulder flexion and abduction, 20° of elbow extension, 10° of wrist extension, 10° of abduction or extension of the thumb, and 10° extension in at least two fingers (metacarpophalangeal and interphalangeal joints) and thumb; present asymmetry in the use of the upper limbs with score 2.5 in the Motor Activity Log (MAL) Quantity Scale; ability to remain in a seated position without support for the trunk and/or of the arms for one minute	Individuals with cognitive deficits; smokers; alcohol; users of illicit drugs; with structural abnormalities in the cardiovascular and respiratory systems,  uncorrected auditory and visual deficits, abnormalities on the electrocardiogram such as ischemic changes, arrhythmias, conduction disorders at rest and/or during the clinical exercise test; diseases or osteomiarticular alterations that affect the data collection or generate pain during the activities; obese (Body Mass Index more than 28 kg/ m2); diabetes mellitus and uncontrolled hypertension; comprehension aphasia; apraxia; stroke bilateral or acute or subacute stroke (less than 6 months) or transient vascular accident and other the central and peripheral nervous system diseases; who are participating in other experimental or rehabilitation studies; who have had botulinum toxin application in the last three months prior to evaluation will be not included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-8f5w2q	Effect of brain stimulation by electric current on eating behavior in overweight people	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1767	Effect of transcranial direct current stimulation (tDCS) on eating behavior in participants with excess of	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-06	Faculdade de Ciências da Saúde do Trairi - FACISA	Faculdade de Ciências da Saúde do Trairi - FACISA	https://ensaiosclinicos.gov.br/rg/RBR-8f5w2q	<NULL>	Age between 19 and 50 years; body mass index equal to or greater than 25; abdominal circumference greater than 94 centimeters for men and greater than 80 centimeters for women	Pregnant and breastfeeding women; women in menopause; user of illicit drug, use of psychotropic medication and for weight loss; previous or current history of eating disorder, psychiatric; suffered a stroke, head trauma, neurosurgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-6xvdmz	NaCl 0,9% vs. Latate&apos;s Ringer&gt; Effects on postoperative results of myocardical revascularization surgery with cardiopulmonary by pass	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1769	NaCl 0,9% vs. Latate&apos;s Ringer&gt; effects on postoperative results of Myocardical Revascularization Surgery with cardiopulmonary by pass	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2017-05-28	Fundação Universitária de Cardiologia	Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-6xvdmz	<NULL>	Patients submitted to surgical myocardial revascularization with CPB, elective and primary, with age ranging between 50 and 75 years old and both sexes	"Preoperative: Urgency or emergency surgery,  INR higher 1,3, when are lower than 100.000,  altered KTTP in the absence of heparine use, use of antiplatelet agents except acetylsalicylic acid, renal insufficiency and or creatinine higher 2, hepatic insufficiency and or GOT e GPT levels more than two times the normal value, previous coagulopathy, pregnancy, breast-feeding, serum potassium higher 5.5 during preoperative period. Diagnosed diseases Von Willebrand, hemophilia, sepsis, hepatic cirrhosis and seizures
Transoperative CPB duration higher than 160 minutes and realization of profound hypothermia with circulatory arrest"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9fsxnn	The effect of Dental materials for the caries treatment	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1770	Efficacy of protective pulp materials in selective caries removal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-9fsxnn	<NULL>	Children between 5 and 9 years of age, of both genders, who do not present systemic pathologies; no history of allergic reaction to the latex of absolute isolation and / or local anesthetic; with a first / second deciduous upper / lower molar compromised by deep caries that reaches two thirds of the dentin; with lack of sensitivity and / or spontaneous pain; absence of pulp exposure; absence of over-mobility; absence of fistula or abscess; radiographic absence of internal and external resorption; radiographic absence of rhizolysis greater than 1/3 of the root; radiographic absence of radiolucent image in the periapical and furcation region that may indicate the presence of irreversible pulpitis or pulp necrosis; apparently healthy local gum and tooth with restorative possibility	Presence of systemic pathologies; history of allergic reaction to latex of absolute isolation and / or local anesthetic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-2m2q5c	Contribution of Changing Eating Habits to reduce the risk of Heart Disease and improve the quality of life of wheelchair  basketball players	Recruiting	Intervention	2018-05-08	<NULL>	<NULL>	1771	Contribution of Nutritional Intervention to reduce the risk of Cardiovascular Diseases and improve the quality of life of wheelchair basketball players	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-23	Centro Universitário de Patos de Minas MG	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-2m2q5c	<NULL>	Athlete of the basketball team in wheelchairs; both genders; aged between 18 and 50 years; practicing the activity for more than thirty days; accepting to participate in the research	Being on medication for weight loss; lipid profile control or glycemic control; being in the use of supplements that interfere in the glucose or lipid metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3878jp	Response of heart rate and blood pressure after exercise on cycle ergometer in subjects after heart surgery	Recruiting	Intervention	2018-05-09	<NULL>	<NULL>	1772	Hemodynamic and autonomic responses of exercise in cycle ergometer in individuals in phase I of cardiac rehabilitation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-14	Universidade Federal de Mato Grosso do Sul - UFMS	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-3878jp	<NULL>	Patients on the second postoperative day of myocardial revascularization surgery; age equal to or greater than 18 years; both genders; conscious and collaborative patients; patients who were hemodynamically stable and without vasoactive drugs	Patients with hemodynamic instability or any factor that impairs or contraindicates sitting and walking; patients with provisional or definitive pacemakers; with acute arrhythmias atrial flutter; atrial fibrillation; second or third degree atrioventricular block; unstable angina; inability to research activities; indigenous patients; institutionalized and quilombolas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-4mb9xb	Effects of whey protein associated with stimulation of anterior thigh muscles after anterior cruciate ligament reconstruction surgery	Recruiting	Intervention	2018-05-10	<NULL>	<NULL>	1775	Effects of whey protein associated with the neuromuscular electrical stimulation of the femoral quadríceps after reconstruction of the anterior cruciante ligament	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4mb9xb	<NULL>	Individuals with unilateral rupture of the Anterior Cruciate Ligament verified arthroscopically or by magnetic resonance imaging and who will undergo Anterior Cruciate Ligament reconstruction surgery	Patients with a history of renal disease; lactose intolerance; diabetes; history of surgery or contralateral knee dysfunction; any dysfunction or surgery in the hips; ankles or feet and for both groups; any neurological, cardiovascular; metabolic; rheumatic or vestibular disease; presence of cardiovascular or respiratory disease that impedes the performance of the study movements and patients who refuse to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3dngn4	Effect of backward walking treadmill training on locomotor capacity after stroke	Recruiting	Intervention	2018-05-10	<NULL>	<NULL>	1776	Effect of backward training on locomotor capacity of individuals with hemiparesis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-09-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3dngn4	<NULL>	People with stroke living in the community will be eligible if they are: &gt; 6 &lt; 18 months after their first stroke;community-dwelling and have been discharged from formal rehabilitation ; capable of providing consent (Mini Mental State Exam score &gt; 23); older than 20 years of age; able to independently walk 10 m without walking aids &gt; 0.4 &lt; 1.2 m/s.	They will be excluded if they have: unstable cardiac status which would preclude participation in a moderate exercise program; severe cognitive deficits and/or language problems which might prevent them from following instructions during the data collection and/or interventions; adverse health conditions which might affect their walking capacity (eg, vestibular disturbances, severe arthritis, or other neurological disorders).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-32vrj6	Effects of Cardiac Rehabilitation on Exercise Tolerance, Endothelial Function, Heart Variability and Quality of Life in Heart Transplants.	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1778	Effects of Cardiac Rehabilitation on Functional Capacity, Endothelial Function, Cardiac Variability and Quality of Life in Heart Transplant recipients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Pernambuco-UFPE	Universidade Federal de Pernambuco-UFPE	https://ensaiosclinicos.gov.br/rg/RBR-32vrj6	<NULL>	Individuals with an age range greater than 18 years and less than 65 years of age; of both sexes; who underwent heart transplant surgery in a superior period for 6 months; with clinical stability; using regular immunosuppressive therapy, with no change in class of medications within three months prior to the start of the study	Patients who present with orthopedic, neurological or respiratory diseases that may make it impossible to perform cardiopulmonary and exercise tests; patients who are undergoing dialysis; and those patients who present psychic alterations that restrict them to respond to the questionnaires and the elderly who carry out the test Time up and go in time greater than 20 seconds, characterizing risk of falls	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-9jgz9d	Creation of reminders to improve nurses&apos; practice regarding registration and use of the child&apos;s book	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1779	Behavioral technology for nurses to enroll and use the child&apos;s book	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Estadual do Ceara	Universidade Estadual do Ceara	https://ensaiosclinicos.gov.br/rg/RBR-9jgz9d	<NULL>	Work on family health strategies that perform child care, work on family health strategies that are located in the urban and rural areas of the municipality of barro	Medical license, physical or mental condition that makes it impossible to participate in the research periodo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-3n3hwh	The use of Video Game for Rehabilitation in the elderly	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1780	Effect of Virtual Reality as new tool for Physiotherapy of older: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-01	Escola de Educação Física da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3n3hwh	<NULL>	Elderly sarcopenic;age 65 or older;with postural instability	Cognitive changes;Inability to stand without help;Inability to perform independent gait; Lesions and/or musculoskeletal symptoms that make it impossible to perform the training; fractures and/or orthopedic lower limb surgeries in the last year;Diseases of the labyrinth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-59h84g	Description of health-related quality of life and evaluation of the use of Cosmetic Camouflage in patients with Systemic Lupus Erythematosus and skin scars caused by the disease	Recruiting	Intervention	2018-05-11	<NULL>	<NULL>	1781	Impact of the use of Cosmetic Camouflage on health-related quality of life in patients with Systemic Lupus Erythematosus and cutaneous manifestations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Santa Casa de Misericórdia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-59h84g	<NULL>	Age greater than or equal to eighteen years; signature of the Informed Consent Term (TCLE);presence of scars of cutaneous manifestations of the disease on the face	Moderate to severe disease activity at the time of inclusion or during the study (defined as SLEDAI 2k-Modified&gt; 4, excluding cutaneous manifestations); not understanding the questionnaires; patients who have initiated psychological and / or psychiatric treatment, with or without medication, within four weeks prior to the start of the study and during its execution or who have undergone treatment modification during the study; development of allergic reaction to the cosmetic product used; moderate to severe cutaneous activity assessed by a rheumatologist	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:10
RBR-2szg8b	The effect of ozonated oil on patients with osteoarthritis.	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1786	Ozonated oil via topic in degenerative articular disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2szg8b	<NULL>	Patients over 50 years of age; Patients who self report having the diagnosis of osteoarthritis.	Patients who have severe cognitive disorders;cancer patients; hospital discharge for less than 30 days; or indigenous people; or have, in addition to osteoarthritis, another chronic inflammatory disease will affect the laboratory results of this research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-93dp9n	Efficacy of Sofosbuvir as treatment for Yellow Fever	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1787	Efficacy of Sofosbuvir as treatment for Yellow Fever: randomized clinical trial (SOFFA trial)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-05	Fundação Faculdade de Medicina	Fundação Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-93dp9n	<NULL>	Age above 18 years, admission in one of the recruiting centers, fever (axillary temperature above 37.8°C), coming from a risk region with epizootic or confirmed human cases (defined according to updated epidemiological bulletins), transaminases above 500 U/L.	amiodarone use in the last 72 hours,  current pregnancy, women who do not accept interruption of breastfeeding, current use of sofosbuvir for hepatitis C treatment, negative RT-PCR for yellow fever, alternative diagnosis that justifies the symptoms on admission.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-2pqvv4	Restorations in traumatized permanent anterior teeth	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1788	Restorations in traumatized permanent anterior teeth: a clinical, controlled and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2pqvv4	<NULL>	Age between 8 and 14 years old; having a permanent upper anterior tooth (central incisors, lateral incisors or canines) requiring class IV restoration, due to uncomplicated coronary fracture, physical and emotional conditions capable of tolerating the restorative procedure, pulp vitality and accept to respond to the questionnaire applied.	Patients with pulpal inflammation or necrosis; previous endodontic treatment; uncontrolled periodontal disease; parafunctional habits; special needs or motor deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7y6f3j	Effect of video game training and conventional physiotherapy on improving the balance of the elderly	Recruiting	Intervention	2018-05-14	<NULL>	<NULL>	1791	Effects of Cognitive Motor Training in real and virtual environments on postural control of the elderly: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7y6f3j	<NULL>	Community dwelling elderly individuals, aged 65 years or over; of both sexes; with a functional state capable of remaining standing, and walking without assistance; without cognitive impairment in the Mini-Mental State Examination89 (&lt;18 for illiterate individuals and &lt;26 for those with an educational level greater than 8 years); normal or corrected hearing acuity (Whisper Test)90; normal or corrected visual acuity (Snellen)91; with no prior experience with the games of the system; and who sign the Free and Clear Informed Consent.	Neurological and orthopedic diseases; the inability to remain in a standing position or walk without assistance; cardiorespiratory diseases that result in clinical alterations; angina; cardiac insufficiency; decompensated blood pressure; behavioral alterations that interfere with the development of the study; incapacitating pain; a history of seizures; and missing more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-3g38dx	Effects of two sessions of Physical Training on the genetic means in women aged 50 to 70 years	Recruiting	Intervention	2018-05-15	<NULL>	<NULL>	1793	Global Screening of Genetic and Epigenetic factors sssociated with magnitude of response to different Physical Training in women 50-70 Years	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3g38dx	<NULL>	Woman aged 60 and over 70 and present medical clearance certificate for physical exercise	To reach a score below the cut-off point in the cognitive performance assessment performed by the Montreal Cognitive Asessment; to be diagnosed with some neurological disease and to present auditory, visual and motor deficits; to be currently smokers and / or in the last six months and to consume caffeine in the last 24 hours before the collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-7pyznv	Training of Breathing Muscles in children after renal Transplantation	Recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1799	Inspiratory Muscle Training in pediatric patients after kidney Transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-22	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7pyznv	<NULL>	Renal transplant recipients up to six months post-transplant; of both sexes; aged between 6 and 18 years; under follow-up at the Nephrology Outpatient Clinic of Santo Antonio Children’s Hospital; and whose parents or guardians agree to participate by signing the written informed consent	Patients with severe underlying lung disease; associated neurological disease; orthopedic disease that not allow the test performing; contraindicated patients to perform pulmonary function tests according recommendations from Brazilian Guidelines for Pulmonary Function Testes; patients with cognitive difficulty to understand and perform tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:11
RBR-776gwc	Comparison of continuous aerobic exercise effect with interval high intensity exercise in patients with heart failure	Recruiting	Intervention	2016-05-12	<NULL>	<NULL>	1803	Effect of high intensity interval training verses moderate intensity continuos training in functional capacity and quality of life of patients with heart failure: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-07	Universidade Federal de Minas Gerais	Hospital Messejana Dr. Carlos Alberto Studard Gomes	https://ensaiosclinicos.gov.br/rg/RBR-776gwc	<NULL>	Individuals with heart failure ; functional classes II and III of the New York Heart Association ( NYHA) ; ejection fraction less than 50%; both genders ; medical clearance ; optimal medical treatment	Subject that presented new cardiac event; clinical decompensation against that indicate the continuity of the physical activity program; and / or to submit physical limitation that prevents participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-73x5yc	Effect of a Mother-oriented treatment and physiotherapy on the Mother&apos;s Anxiety, number of Gusts and Cry time in young and healthy babies	Recruiting	Intervention	2018-05-16	<NULL>	<NULL>	1806	Effect of an intervention with Maternal Care guidelines and Manual Therapy on Maternal Anxiety, number of Regurgitations and time of Crying in young and healthy infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-73x5yc	<NULL>	Mothers over 18 years of age with full term newborns greater than or equal to 37 weeks of gestational age and less than 42 weeks of GI, healthy, with an Apgar score greater than 7 at the fifth minute, and with age-appropriate birth weight gestational	Mothers with impaired comprehension and verbal language will be excluded. It will be excluded newborns with Apgar less than seven in the fifth minute, malformation, neurological disease, congenital infection, and infants who throughout the study have a diagnosis of gastroesophageal reflux disease, with a history of aspiration, apnea, growth restriction , weight loss and difficulty in swallowing, allergy to cow&apos;s milk protein, in this study considered as presence of blood in the stool, inflammation of the anus, severe atopic dermatitis and use of formulas to treat food allergy; history of seizure and  or diagnosis of metabolic disease and use of medications such as domperidone, bromopride, metoclopramide, omeprazole and ranitidine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:12
RBR-6tps79	Motor function in patients with brain injury submitted to an exercise protocol	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1821	Functional Impact in Patients with Acute Brain Injury undergoing an Early Mobilization Protocol	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6tps79	<NULL>	Individuals who have suffered acute brain injury; diagnosed and confirmed by clinical history and cranial tomography; admitted to the intensive care units of the Santa Casa de Campo Grande Hospital; above 18 years; of both sexes and that the persons in charge of the same are in agreement with the term of free and informed consent	Patients with evidence of pre-existing chronic brain injury; presence of external orthopedic fixators; presence of skeletal traction for fracture treatment; presence of lower limb amputation; trauma or previous surgery of the feet, pelvis or lumbar spine; presence of open abdominal wound; unstable bone injury of the spine or lower limbs; severe agitation; spinal cord involvement; pregnant women; indigenous peoples; quilombolas or institutionalized	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-9b6mnj	Laser for temporary treatment of pain in the temples, face and neck.	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1822	Low laser therapy in palliative care of temporomandibular dysfunction and orofacial and cervical cranial pain	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-10-24	Faculdade de odontologia da Universidade de São Paulo	Faculdade de odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9b6mnj	<NULL>	Adult participants of all ages with primary complaint of pain in the temporomandibular joint region and or orofacial and cervical skull region and or limitation of mouth opening will be included	Participants with: congenital problems with Temporomanbibular joint involvement and or orofacial and cervical skull region; neoplastic conditions; history of recent trauma in the orofacial and cervical skull region; any type of temporomandibular dysfunction treatment plaques; functional orthopedic appliances or fixed and or removable orthodontic appliance; syndromes; cleft lip and or palatine; psychiatric disorders; severe heart problems; tooth in severe precarious conditions, such as periodontitis and or indication of endodontic treatment; in use of topical or systemic photo sensitizing medications, pregnant women, skin related problems in the region to be applied the laser.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-4fhbrp	Registry of patients with Pulmonary Hypertension in Southern Brazil	Recruiting	Observational	2018-05-21	<NULL>	<NULL>	1824	"Registry of patients with Pulmonary Hypertension
in Southern Brazil"	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-10-02	Irmanda da Santa Casa de Misericórdia de Porto Alegre	Freda	https://ensaiosclinicos.gov.br/rg/RBR-4fhbrp	<NULL>	"Male or female patients residents in southern Brazil, of any age with a confirmatory
diagnosis of pulmonary hypertension by a right heart catheterization, from 01.Jan.2006
until 31.Dec.2017.
Patients with pulmonary hypertension from group I to V according to clinical
assessment by WHO, version 2014.
Available right heart catheterization documentation at the time of PH diagnosis
period."	"Patients with confirmatory PH diagnosis outside the specified period will be
excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-5t6bd9	Clinical evaluation of dental bleaching with violet LED	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1826	In vivo analysis of Violet Led associated or not with peroxides on the efficacy and safety of dental bleaching	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-30	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-5t6bd9	<NULL>	"Sign Informed Consent Form; agree to not participate of any other clinical trial during this study; present good general and oral condition;
have not been undergoone dental bleaching over the last 3 years or to present shade higher than A2 (vita SCALE); teeth submitted to dental bleaching with vitality; not present any edentulous space between premolars in both arches; upper right central incisor and canine must present shade higher than A2; the participant must be over 18 and under 60 years old."	Be participating of another clinical trial; not agree to afford for the displacement until the Dental School; present dental caries or gengivitis after clinical examination; present any allergy to one of the materials used in the clinical procedures for bleaching and mineral content analysis; not be able to attend all the appoitments necessary until the end of the treatment; patients with cracks on the teeth that will receive bleaching, once this could enhance tooth sensitivity; present upper right central incisor and canine brighter than A2; present wide restorations on the teeth that will be bleached.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-3wghh4	Comparison of Polishing systems of veneers in anterior teeth	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1828	Effect of the Polishing System on surface roughness of composite resin veneers: randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-16	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3wghh4	<NULL>	"Be at least 18 years old; good general health; do not present periodontal disease;
Coronal darkness and/or extensive and defective restorations covering the buccal face or color and shape alterations that compromise dental esthetics; ; have an anterior tooth with a higid buccal surface for the purpose of comparison of gloss; present opposing and adjacent tooth; patients without systemic disease or allergies to the materials used; absence of parafunctional habits"	Use of removable prostheses with support on the teeth used for the sturdy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-6ffdnx	Alternatives schedules against hepatitis b in homeless person in Goias	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1830	Randomized clinical trial of alternatives schedules against hepatitis b and serum epidemiological study of syphilis and caused infections human immunodeficiency virus and viral hepatitis in homeless person in Goias	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-03-05	Faculdade de Enfermagem Universidade Federal de Goiás	Faculdade de Enfermagem Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6ffdnx	<NULL>	Man aged 18 years or over; who have lived in a street situation for at least 30 days; who are in the place of data collection for a maximum of 30 consecutive days and who are susceptible to the hepatitis B virus.	Man with confirmed serological diagnosis of HIV; with some contraindication of the vaccine.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-63w5nz	Comparing the effect of two different movements systems on pain that occurs after canal treatment	Recruiting	Intervention	2018-05-22	<NULL>	<NULL>	1838	The incidence of postoperative pain after using a reciprocating system and a continuous rotary system: A prospective randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-63w5nz	<NULL>	Patient with physical status classified as ASA I (without systemic disorders) or II (with discrete to moderate systemic disorders) (American Society of Anesthesiologist / ASA); permanent teeth that require the need for endodontic treatment; presence or absence of periapical lesion; absence of symptomatology in the tooth to be treated; male and female gender; ages between 9 and 90 years; teeth with pulpal diagnosis: normal pulp, reversible pulpitis, asymptomatic irreversible pulpitis or pulp necrosis; teeth with apical diagnosis: normal apical tissue and with asymptomatic apical periodontitis	Pregnant patient; teeth with cracks or root fractures; patients who took pre-operative analgesic medication (in the last 24 hours), steroidal or non-steroidal anti-inflammatory and antibiotic (in the last 180 days); patients with periodontal disease; non-endodontic origin periapical lesion; previously accessed teeth; pre-filled teeth; teeth that need retreatment; teeth with pain palpation; teeth with vertical and / or horizontal pain percussion; teeth with spontaneous pain; teeth with mobility grade 2; internal or external resorption; teeth with incomplete rhizogenesis; apical obstruction of the root foramen	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-8w9dbt	Effect of Acupuncture before Wisdom tooth extraction that is not yet born	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1839	Effect of Energetic Regulation with Acupuncture in molar third-party exodontia surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-23	Faculdade de Odontologia da Universidade Estadual de Campinas	Faculdade de Odontologia da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8w9dbt	<NULL>	Volunteers both genres; age between 18 and 30 years; with good general health; with four third molar teeth being the two lower molars included or semi-included with the same anatomical position	Volunteers with lower molars in antagonistic anatomical positions; weakened general health; clinical history of previous infection; carriers of severe emotional disorders; The energy level balanced between the normal range of 40 to 60	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-5jznnt	Comparison of the results obtained in the exam that evaluates the functioning of the bladder with the clinical examination to try to find out if there is difficulty for women to urinate if they have a low bladder or other gynecological diseases	Recruiting	Observational	2018-05-23	<NULL>	<NULL>	1840	Comparison of the results obtained in the urodynamic exam in the flow / pressure study phase with urethral resistance analysis (free flowmetry, maximum detrusor pressure at maximum peak urinary flow and post void residue), with the classification of POP-Q (Pelvic Organism Prolapse Qualification), for the dystopias pelvicase with the quality of life questionnaire, validated for the Portuguese language, to standardize the diagnosis of infravesical obstruction in patients with Urinary Incontinence associated w	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-02	Universidade Federal de São Paulo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-5jznnt	<NULL>	Patients with low urinary complaints.Patients who underwent the Urodynamic Study.Patients who signed the Informed Consent Form.	Patients with urinary infection at the time of the urodynamic study.Patients with Neurogenic Bladder.Patients who refused to sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-63ctjw	Influence of reduction of standard preoperative fasting time and that added with protein in patients with head and neck cancer	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1842	Influence of the standard preoperative fasting and added with protein in patients with head and neck cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Instituto Nacional de Câncer	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-63ctjw	<NULL>	All patients who are candidates for elective surgeries; who are 19 years of age or older; and consent to participate in the study through the signing of the Informed Consent Form.	Volunteers inability to receive oral feeding in the preoperative period; without adherence to any of the phases of the study protocol; in use of prophylactic antiemetics 24 hours before surgery and in the immediate postoperative period; with previous diagnosis of diabetes mellitus, chronic kidney disease and / or liver disease, obesity (WHO, 2000); with presence of gastroesophageal reflux; intestinal obstruction and cases of gastroparesis and / or pyloric stenosis and surgeries with low nutritional impact (base of skull, maxillary sinuses, thyroid gland, parotid glands, cutaneous and ocular).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:13
RBR-4zzc3p	Comparison of a local anesthetic technique applied by syringe or by computer	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1843	Comparative study of length and duration of Inferior Alveolar Nerve Block with Lidocaine 2% + Epinephrine 1: 100.000 applied by conventional technique or computerized system	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2017-11-08	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4zzc3p	<NULL>	Volunteers aged between 18 and 35 years; who have not undergone blockade anesthesia in the region in the two weeks prior to the study; present 02 lower molars in need of restorative treatment; not having used any medication that could alter the perception of pain in the two weeks prior to the study.	Hypersensitivity to drugs used in the study - 2% Lidocaine with epinephrine 1: 100,000; Benzocaine 20%; presence of organ dysfunction or clinically significant deviation from normal, assessed during anamnesis; odontophobic; pregnant and / or lactating women; history of drug addiction or alcohol abuse.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-35tnj7	Effect of laser therapy on clinical and subjective aspects in implant placement: A randomized clinical trial	Recruiting	Intervention	2018-05-23	<NULL>	<NULL>	1844	Influence of low level laser therapy on clinical and subjective aspects in dental implant placement: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-11-08	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-35tnj7	<NULL>	To be included in the sample the patients should need for extraction of any teeth due to root crack/fracture or perforation with indication of immediate implant installation; good general health, which allow the tooth extracion and implant installation procedures; time availability to attend the follow-up appointments.	Patients presenting poor general health that prevents the accomplishment of the surgery for installation of dental implant; and patients who do not have available hours to attend for dental treatment and follow-up appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-3p7wsr	Effects of interactive games on brain activation and quality of life of individuals with spinal cord injury	Recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1846	Effects of Virtual Reality on brain activation and quality of life of individuals with Spinal Cord Injury	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-30	Universidade de Franca	Centro Universitário de Patos de Minas	https://ensaiosclinicos.gov.br/rg/RBR-3p7wsr	<NULL>	participants of both sexes; age between twenty and fifty years; clinical diagnosis of complete and / or incomplete spinal cord injury; at least one year of injury; be able to tolerate static posture for at least five minutes without minimal assistance; agree to discontinue the traditional treatment of physical therapy during the period of data collection.	Participants with significant orthopedic injuries that could limit seated posture, such as severe contractures or cutaneous lesions in the lower limbs; presenting spinal stabilization devices that limit mobility; osteoporosis; uncontrolled cardiovascular instability; neurological disorders other than spinal cord injury, eg, stroke, which may interfere with the performance of mental practice; medical diagnosis of dementia diseases such as Alzheimer&apos;s Disease, Vascular Dementia, Mixed Dementia, Lewy Body Dementia, Frontotemporal Dementia; clinical diagnosis of depression; use of antidepressant medications; cognitive impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-9d5n4g	clinical trial for evaluation of Tooth Whitening in different application techniques	Recruiting	Intervention	2018-05-24	<NULL>	<NULL>	1847	Combined, At-home and In-Office Dental Bleaching: efficacy, clinical parameters follow-up and enamel evaluation of calcium and phosphorus concentrations	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Faculdade Centro de Pesquisa São Leopoldo Mandic	Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP	https://ensaiosclinicos.gov.br/rg/RBR-9d5n4g	<NULL>	Inclusion criteria: aged 18 to 30 years, the presence of at least 20 teeth and the presence of the elements 11, 21, 22, 12, 13, 23, 31, 32, 33, 41, 42, 43 healthy or at most 1 / 6 restored labial surface.	The exclusion criteria of this study are: teeth with initial color B1 assessed by spectrophotometer (VITA Easyshade® Advance, Vita, Germany), patients with removable dentures or fixed and removable orthodontic appliances participants pregnant or breastfeeding, smoking participants, participants with prior dentinal sensitivity, presence of active caries lesions in enamel and dentin, periodontal disease and other oral lesions, pigmented teeth tetracycline and patients who received prior bleaching treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-9w92fv	Effects of Auricular Therapy in the treatment of Premenstrual Syndrome	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	1848	Effects of Auricular Therapy in the treatment of women with symptoms of Premenstrual Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9w92fv	<NULL>	WWomen aged 18-35 years; sedentary; university students enrolled regularly at the Federal University of Paraná; and who have Premenstrual Syndrome (mild to moderate) or Pre-Menstrual Dysphoric Disorder according to the criteria listed in the PSST (Premenstrual Syndrome Screening Tool)	Women classified by PSST as mild or absent Premenstrual Syndrome; in the gestational period; with irregular menstrual cycles (cycles less than 25 days or greater than 35 days); women diagnosed with secondary dysmenorrhea (fibroids, endometriosis or cysts); who have a history of abortion; cardiopathy; who use antidepressants and / or psychotropic medication in the last two months; and, that they have any type of lesion in the auricular pavilion.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-64wrvv	Physical Therapy for Sexual Dysfunctions Caused by the Treatment of Cervical Cancer	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	1850	Physical Therapy in Sexual Dysfunctions from the Treatment of Cervical Cancer in a Public Hospital in Belém do Pará	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade do Estado do Pará	Hospital Ophir Loyola	https://ensaiosclinicos.gov.br/rg/RBR-64wrvv	<NULL>	Women aged between 35 and 65 years; women diagnosed with cervical cancer, women who underwent pelvic radiotherapy by teletherapy or brachytherapy with or without surgery, women who agree to participate in the study by signing the informed consent form	Women with diabetes; with hyperprolactinemia, with hypothyroidism; with any other condition that may alter the results of the present study; those who refuse to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-748nrs	Repetitive transcranial magnetic stimulation for tinnitus treatment	Recruiting	Intervention	2018-05-25	<NULL>	<NULL>	1852	Effects of repetitive Transcranial Magnetic Stimulation on chronic tinnitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-03	Instituto de Psiquiatria Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-748nrs	<NULL>	Age between 18 and 75 years of age. Presence of tinnitus between 6 months and 5 years. Moderate to catastrophic annoyance with tinnitus measured by the Tinnitus Handicap Inventory. Normal hearing test or sensorineural hearing loss compatible with age.	"Objective tinnitus. Incapability to answer the scales and questionnaires. Neurologic or cognitive diseases. External or middle ear disease.
Tinnitus with specific treament of the basic cause as thyroid hormones, somatossensory tinnitus. Use of pacemakers or metallic components in the head and neck region. Pregnancy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-6qr863	Use of denture adhesive in the period of adaptation with new complete dentures in patients with normal and resorbed ridges	Recruiting	Intervention	2018-05-28	<NULL>	<NULL>	1855	Use of denture adhesive in the period of adaptation with new complete dentures in patients with normal and resorbed ridges	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-06-22	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6qr863	<NULL>	Adults ndividuals; both genders; bimaxillary edentulous; aged 40 to 90 years; both genders; users of conventional complete dentures; requiring replacement of dentures; receptives; mentally agiles; good understanding of speaking Portuguese; mandibular ridges with normal or resorbed volume; normal amount and quality of saliva; no previous experience of denture adhesive; new dentures considered satisfactory	Debilitating systemic diseases; pathological changes in the oral tissues; neuromuscular impairment; temporomandibular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:14
RBR-7ncggq	Evaluation of Pain after Knee Surgery using Pregabalin before and after Surgery	Recruiting	Intervention	2018-05-30	<NULL>	<NULL>	1860	Postoperative Pain analysis with perioperative administration of Pregabalin in patients submitted to Knee Arthroscopy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-02	Hospital São Domingos	Universidade Federal de São Paulo - Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-7ncggq	<NULL>	"Patients diagnosed with chronic knee instability; patients older than 18 years; physical status classification according to the scale of the American Society of Anesthesiologists (ASA) I and II;
without local and systemic inflammatory diseases; isolated lesions of the anterior cruciate ligament (no other knee ligaments);
no history of fractures in the knee region;
absence of previous surgeries in the knee region; operated by the orthopedist of the team;
ability to read, understand and agree to the inclusion of your data
in this research."	"Skeletally immature patients; chondral lesions greater than 2 cm2; associated surgical procedures, such as osteotomies, and other knee ligaments; neurological, muscular, rheumatologic, neoplastic or infectious diseases that could provoke some type of joint involvement (gout, multiple myeloma,
psoriasis, lymphoma, Paget&apos;s disease, rheumatoid arthritis, chronic renal failure,
osteomyelitis, ankylosing spondylitis, systemic lupus erythematosus); patients without clinical conditions, hypertensive, with coagulopathies, pregnant women; chronic use of anticoagulants; use of analgesics up to 24 h before the surgical procedure; patients who refused to sign the EHIC; patients not operated at the São Domingos Hospital; refusal or impossibility of the patient to perform the postoperative rehabilitation; non-acceptance of the anesthesiologist in following the protocol of the project; patients allergic to the medications used in the protocol; patients who declared themselves indigenous."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-858qxn	Comparation between the techniques of Extubation in the Surgical Block and the Intensive Care Unit on the regional lung ventilation assessed by Electric Impedance Tomography in patients undergoing Noninvasive Ventilation following  Heart Surgery: a cross-sectional study	Recruiting	Observational	2018-05-30	<NULL>	<NULL>	1861	Comparation of Ultra-Fast-Track and Fast-Track techniques in the regional lung ventilation assessed by Electrical Impedance Tomography in patient undergoing prophylactic nasal positve airway pressure following Cardiac Surgery: a cross-sectional study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-858qxn	<NULL>	Ages between 18 and 65 years; body mass index  between 18.5 and 30 kgm2; undergo the Ultra Fast Track and Fast Track extubation techniques; without chronic obstructive pulmonary disease; pulmonary fibrosis; or chronic renal failure; or associated neuromuscular diseases; and those who have an American Society of Anesthesiologists perioperative risk score of less than 4.	Liver failure; congestive heart failure; dementia and Alsheimer&apos;s disease; left ventricular ejection fraction less than 40%; anticonvulsant; antidepressant; psychoactive drug in use and emergency reoperated patients; high surgical risk according to EuroSCORE II; presente cardiopulmonary bypass time great than 120 minutes; bleeding with thoracic drainage great than 100 mLh; renal failure with urine output less than 0.5 mLh in the first 6 hours; increased serum creatinine level less than 50% the baseline; prolonged inotropic and vasodilatory drugs support due to cardiac problems; extubation failure for hypercapnia; more than a failure in the autonomic test; mechanic ventilation assist time greater than 6 hours; hemodynamic instability; cardiogenic shock; severe hypotension with systolic blood pressure less than 90 mmHg; episode abdominal distress; nausea and vomiting; depressed level of consciousness; use of accessory muscle; respiratory rate great than 35 ipm; hypoxemia with PaO2 less than 50 mmHg with FiO2 of 50% or hypercapnia with PaCO2 great than 55 mmHg and with pH less than 7.30.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-4gzj9m	Effect of Gluten Consumption on pain sensitivity of women with Temporomandibular Dysfunction	Recruiting	Intervention	2018-06-02	<NULL>	<NULL>	1865	Influence of Gluten Intake on mechanical somatosensory mechanisms of women with Myofascial Pain of the Masticatory Musculature	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Departamento de Odontologia Restauradora da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4gzj9m	<NULL>	Women. 20 to 45 years. Myofascial Pain in Masticatory Musculature for at least 3 months. Pain rating of at least 5.	Toothache. Fibromyalgia. Primary Headache. Diabetes uncontrolled. Uncontrolled hypertension. Lupus. Leprosy. Multiple sclerosis. Hypothyroidism. Carpal tunnel syndrome. Intracranial hypertension. Pregnancy. Previously diagnosed disabling psychological and neurological changes. Chikungunya fever. Dieting restrictive. Present signs and symptoms of intolerance, sensitivity or allergy to gluten. They should not have been treated for TMD in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-2qpdw4	Bloog glicose control following surgery and the ocurrence of Infection on the surgical site among Liver Transplantation recipients	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1872	Postoperative Blood Glucose Control vs. Surgical Site Infection incidence among Liver Transplantation recipients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-21	Escola de Enfermagem da Universidade de São Paulo	Santa Casa de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-2qpdw4	<NULL>	"Liver transplantion recipients, age of 18 years or older.
Liver transplantation recipients whose allograft came from deceased donors."	"Liver transplantation recipients underwent any kind of surgery with or without prosthesis implant in the 30 days before the transplantation.
Liver transplantation recipients who will be submitted to multiple organ transplantation."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-9w9m83	Comparative analysis in implant-supported metal ceramic and hibrid ceramic crown	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1873	"Comparative analysis of Clinical and Molecular parameters in implant-supported Metal Ceramic and 
Hybrid Ceramic crowns"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-03	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-9w9m83	<NULL>	Edentulous sites for replacement of unitary prostheses in the premolar or molar regions; bone height at least 8.5 mm; minimum cervical bone thickness of 5 mm; minimum age of 18 years; ASA I or ASA II patients; periodontally healthy adjacent teeth without previous treatment of chronic / aggressive periodontal disease and without the need for prosthetic restoration; healthy natural antagonist teeth (absence of restorations or prostheses) and periodontally healthy.	History of alcoholism; smokers; illicit drug users; cardiopathy; decompensated diabetics; complex rehabilitation needs (alteration of vertical dimension of occlusion, need for other rehabilitation procedures); lack of height and sufficient bone thickness; patients with parafunctional habits (bruxism); grafted areas;  irradiated patients; patients who underwent long-term steroid therapy or bisphosphonate users; periodontally compromised patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-6vg875	The effect of Environmental Light on Sleep and Level of Urinary Melatonin in women who gave birth	Recruiting	Intervention	2018-06-05	<NULL>	<NULL>	1874	The effect of Environmental Light on Sleep and Level of Urinary Melatonin in Postpartum Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-11	Escola Paulista de Enfermagem  da Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6vg875	<NULL>	"Postpartum women: more than 18 years of age; having given birth to an only child; living together for at least 24 hours; being literate; not working at night in the last 3 years; not using illicit drugs during pregnancy; agreeing and signing the free and informed consent term.
Newborns: born of any type of birth; full term; by gestational age (DUM); chronological age greater than or equal to 24 hours; birth weight over 2000 grams; no malformations; female or male; and those who are mothers to agree and sign the informed consent form for participation of the neonate in the study."	Postpartum women who present any type of complication after delivery; newborn in phototherapy; with malformation; or postpartum women whose neonate is transferred to another unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-4g4sk8	Effects of intraarticular infiltration in  rheumatoid arthritis women´s knees	Recruiting	Intervention	2018-06-06	<NULL>	<NULL>	1877	Effects of Intraarticular Infiltration of Triamcinolone Hexacetonide in Rheumatoid Arthritis women´s knees on static, functional and inflammatory activity measurements: a randomized, controlled, blinded clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2017-01-24	Universidade Estadual Paulista - UNESP	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-4g4sk8	<NULL>	Diagnosis of RA according to the American College of Rheumatology (ACR) Classification Criteria of 1987 or Classification Criteria for RA 2010 of the ACR / EULAR; Age over 18 years; Female gender; Analog Visual Scale (EVA) of knee pain between 40 and 80 mm; EVA of knee edema between 40 and 80 mm; Be stable with drugs modifying the course of the disease in the last 3 months and / or oral corticosteroids in the last month; Presence of refractory knee injury in the last 3 months.	Injury and / or diseases symptomatic knee than RA; radiographic classification of Kellgren-Lawrence grade IV; Knee prosthesis in the target joint; prior realization of any IIAC in the last 6 months; Symptoms of systemic or local infection; reported hypersensitivity to the drug components or contraindication to the use thereof;Suspected or confirmed pregnancy; Physical therapy or other treatment in parallel to symptom in knee; Uncontrolled systemic arterial hypertension; Previous knee surgery to be evaluated; Skin lesions at the IIA site; Deficit vision or hearing or cognitive preventing the completion of the evaluations proposed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-6d9cd6	Functional and posture training in patients with inflammation of the plantar fascia	Recruiting	Intervention	2018-06-06	<NULL>	<NULL>	1878	Functional training and postural control in patients with plantar fasciitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6d9cd6	<NULL>	Medical diagnosis of plantar fasciitis and /or heel spur; duration of symptoms greater than four months; ages between 30 and 65 years	Spondyloarthritis; fat-pad atrophy; proximal plantar fibroma; history of previous surgery and lower limb trauma; musculoskeletal or neurological disease that may predispose to heel pain and decrease muscle strength; discrepancy greater than 1.5 cm between lower limbs; having undergone physiotherapeutic intervention for this lesion and/or Pilates exercises in the last six months; and body mass index (BMI) greater than or equal to 34.9	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:15
RBR-3rx7sr	Effect of electrical stimulation applied on the scalp associated with hip musculature training in women without complaints of urinary incontinence	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1884	Effect of transcranial direct current stimulation (TDCS) combined with pelvic floor muscle training on the contraction force of the pelvic floor muscles in healthy women – Protocol for a randomized, controlled, double-blind, clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-23	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-3rx7sr	<NULL>	Women who had vaginal deliveries age between eighteen and fifty-nine years; No complaint and diagnosis of urinary incontinence; evaluated by Pelvic Floor Impact Questionnaire PFIQ-seven; Sexually active	Women who present with bladder prolapse greater than or equal to two; which prevent the introduction of the vaginal catheter; In treatment with radiotherapy in the pelvic region; In treatment of urinary infection or other conditions in the pelvic region; Pregnant women; Have a pacemaker; That they present contraindications to the use of CTEC history of recurrent seizure; tumors or skin infection at the site of stimulation and metallic materials implanted in the brain; Who presented anesthesia or hyperesthesia at the point of application of the ECTS; Positive cut-off point for the Mini Mental State Examination MMSE lower than eleven points already corrected for schooling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-57nftj	Effect of an educational intervention on adherence to treatment for Syphilis in postpartum women and their partners	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1885	Impact of an educational intervention on the follow-up of postpartum women with Syphilis and their sexual partners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-02	UFG- Hospital das clínicas da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-57nftj	<NULL>	Minimum age of 18 years; 6 hours after delivery; Infection by Treponema pallidum in prenatal, childbirth, immediate pre-delivery and / or puerperium; Indication of treatment in the last 30 days before delivery or in the puerperium; Non-treponemal test (VDRL) reagent in any titration; Record of inadequate treatment for prenatal syphilis	Inability to answer questions on forms and questionnaire; To present a diagnosis of mental disorders recorded in medical records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-68895k	Homeopathy on mental health care	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1886	Homeopathy on primary care mental health	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-06-07	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-68895k	<NULL>	Users of the Basic Health Unit Cidade Aracy (Sao Carlos - Sao Paulo/Brazil), who are on antidepressants; and/or benzodiazepines; without psychiatric follow-up in the 12 months prior to inclusion	Schizophrenia; bipolar and substance use disorders (except benzodiazepines and tobacco). A suicide attempt in the 12 months prior to inclusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-85qvn9	Older women with urinary loss: evaluation and treatment with Exercise and Physiotherapy	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1888	Older Women with Urinary Incontinence: evaluation and intervention through Physical Exercise and Physiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-09-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-85qvn9	<NULL>	Female volunteers, with 60 years or more, with symptoms of urinary leakage during activities with efforts, urinary loss objective above two grams in pad test and preserved cognitive function.	Current or recent (within 6 months) physical therapy intervention for symptoms of stress urinary incontinence, presence of urge UI, because causes neurological or urinary tract infection, have practiced strength training for the past 6 months and presence of diseases that constitute contraindications for performing weight training as decompensated hypertension, osteoarthritis progress, fibromyalgia and surgery, fractures or ligament ruptures recent disc protrusion advanced and advanced postural deviations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-6dv5kj	Effects of respiratory muscle training on pulmonary and respiratory muscle function, cardiac function and function of individuals with Parkinson&apos;s disease	Recruiting	Intervention	2018-06-13	<NULL>	<NULL>	1890	Effects of inspiratory muscle training on pulmonary and respiratory muscle function, autonomic heart function and functional capacity of individuals with Parkinson&apos;s disease: a controled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6dv5kj	<NULL>	"Individuals with idiopathic PD diagnosed previously by a neurologist physician;
Aged 50-65 years; 
Classified in stages I to III of the modified Hoehn and Yahr Scale; 
Ability to walk independently."	"History of chronic or acute non-controlled cardiovascular and respiratory diseases; 
Individuals with cognitive; 
Another neurological disease; 
Change of medication."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-9x3tkp	Evaluation of pelvic floor muscles in orthostatic and gynecological positions in women with urinary loss	Recruiting	Observational	2018-06-13	<NULL>	<NULL>	1891	Evaluation of the strength and function of pelvic floor muscles in women with stress urinary incontinence in the standing and supine positions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-04-30	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-9x3tkp	<NULL>	80 women with stress urinary incontinence; or mixed urinary incontinence with predominant stress symptoms; the diagnosis of the type of incontinence was based on clinical parameters and the pad test	Patients younger than 18 years and above 65 years; with predominance of urgency or urge-incontinence symptoms; chronic degenerative diseases; uncontrolled metabolic diseases; neurological or psychiatric disorder; who have participated in pelvic floor rehabilitation programs previously and/or pelvic floor surgeries, or who are performing another type of treatment for urinary incontinence; with presence of genital prolapse grades II, III and IV; incapable of voluntarily contracting the muscles of the pelvic floor; with a body mass index greater than 25 kg/cm2; and women who feel discomfort with the devices used to evaluate the pelvic floor muscles	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-8m8cf2	The effect of the release of composite resin components on restoration to gingival tissue	Recruiting	Observational	2018-06-13	<NULL>	<NULL>	1892	Release of components of a resinous restorative system	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8m8cf2	<NULL>	Older than 18 years, systemically healthy, non-smoking, with good oral hygiene, with absence of irreversible pulpal alteration, with the presence of a non-carious cervical lesion (LCNCs) that needs to be restored, normal periodontium	With severe systemic alteration, in the use of antibiotics and anti-inflammatories in the last three months, with altered periodontium, non-smoking only, who have performed other restorations in the last 6 months, pregnant women and infants, periodontal sites that presented bleeding during crevicular fluid collection or sites that prevent adequate collection of clinical parameters	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-7cfdxm	Problemas de nutrição em meninos que tem a fraqueza muscular conhecida como distrofia muscular de duchenne.	Recruiting	Intervention	2018-06-14	<NULL>	<NULL>	1897	Nutritional Intervention in Duchenne Muscular Dystrophy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-01	Departamento de Nutrição	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7cfdxm	<NULL>	Children and adolescents up to 19 years and 8 months at the beginning of the research; confirmed diagnosis of Duchenne Muscular Dystrophy.	Boys who show signs of acute infection on the day of the evaluations; or who, during the study, are hospitalized; undergo surgery; or do not wish to continue participating in it.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:16
RBR-78tyjr	Perineal muscle strength, sexual intercourse, and involuntary urine loss	Recruiting	Observational	2018-06-14	<NULL>	<NULL>	1900	Correlation of muscle function of the pelvic floor with female sexual and urinary functions	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-78tyjr	<NULL>	The research will be conducted with women who will be submitted to the PCCU (preventive), with a minimum age of 18 years and who are sexually active	Neurological problems, hypertension, diabetes and / or menstrual periods will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-3v2wgx	Quality of Life of pregnant women with Zika Virus	Recruiting	Observational	2018-06-16	<NULL>	<NULL>	1905	Quality of Life of pregnant women diagnosed with Zika Virus	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-07-05	Universidade Federal de Goiás - UFG	Universidade Federal de Goiás - UFG	https://ensaiosclinicos.gov.br/rg/RBR-3v2wgx	<NULL>	"Participants in this study will include  pregnant women notified with Zika Viruses (confirmed and
discarded) regardless of gestational age and age; residing in Goiânia and in the Metropolitan Region, who are prenatal in public health
primary care in Goiânia and in the Maternal and Child Hospital, and that they agree to participate in the
search."	"Pregnant women notified with Zika under the age of eighteen years will be excluded when there is no person responsible for signing the TCLE; pregnant women who present a deficit
cognitive or neurological, making it impossible to fill data; pregnant women who are prenatal in private health units and who do not
agree to participate in the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-23snwx	Efficacy, safety and action of Microneedling and oral Tranexamic Acid in the treatment of facial Stains.	Recruiting	Intervention	2018-06-16	<NULL>	<NULL>	1907	Clinical trial about the efficacy, safety and mechanisms of action of Microneedling and oral Tranexamic Acid in the treatment of facial Melasma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Escola Paulista de Medicina (EPM/UNIFESP)	Escola Paulista de Medicina (EPM/UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-23snwx	<NULL>	women with mild to severe facial melasma with moderately to severe mMASI clinically proven by a dermatologist titled during the medical visit and who have been untreated for melasma for at least 30 days, except for the use of sunscreen	other concomitant facial dermatoses, photosensitivity dermatoses, collagenoses, blood dyscrasias or under the use of anticoagulant medication, immunosuppressed; pregnant and lactating women;phenotypic extremes red and black, because melasma is rarely mentioned in these groups. Obese, users of oral contraceptives, sedentary or with a personal or family history of previous thrombotic event have a higher risk of thromboembolism, so will be deallocated from the block with oral tranexamic acid	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-6c36pg	Performance between real and virtual environments in people with Autism Spectrum Disorders	Recruiting	Intervention	2018-06-18	<NULL>	<NULL>	1908	Analysis of motor performance between real and virtual environments in people with Autism Spectrum Disorders: crossover longitudinal study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-30	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c36pg	<NULL>	The signing of a free and informed consent by the parents or guardians of the minors; Term of assent by the minor; Children and adolescents with mild to moderate ASD; Which courses between 1st and 5th grade of elementary school.	People with severe ASD; Comorbidities such as Attention Deficit Hyperactivity Disorder and Down Syndrome; Use of medications that may interfere with the studied variables; Withdrawal during the protocol; Functional deficiencies that prevent the accomplishment of the tasks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-9zgxzd	Effect of different types of physical exercise in SUS patients with depression	Recruiting	Intervention	2018-06-19	<NULL>	<NULL>	1915	Effect of different low-cost physical exercise programs on the mood indicator, cognitive function, physical activity level, cardiovascular risk and cost with treatment in patients with SUS depressive disorders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-20	Universidade de São Paulo - Escola de educação Física e esporte	Fundação de Amparo a Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9zgxzd	<NULL>	Have a diagnosis of major depressive episode (single or recurrent episode by the Mini International Neuropsychiatric Interview (MINI), evaluated by a psychiatrist-trained evaluator; use of pharmacological treatment for mental health (use of anxiolytic drugs or antidepressants); did not participate in a systematic exercise program in the last 6 months and be able to perform systematic physical exercise (medical authorization); be over 40 years of age; do not have chronic degenerative diseases, dementias (score &lt;23 in the Mini Mental State Examination), joint or muscle injuries that prevent him from carrying out systematized physical exercises.	Not being willing to participate in evaluations; Not having availability of participation of interventions that will occur on weekdays; make use of walking sticks, crutches or other support that hinder the practice of physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:17
RBR-9vddmr	Mucosadhesive formulation for Oral Mucositis relief (PHASE II and III)	Recruiting	Intervention	2017-08-08	<NULL>	<NULL>	1917	Randomized double blind clinical trial of Phytomedicine for prophylactic and curative purposes of Oral Mucositis (PHASE II and III)	<NULL>	2-3, randomized-controlled, triple-blind	2-3	<NULL>	<NULL>	<NULL>	2017-05-08	Faculdade de Odontologia da Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9vddmr	<NULL>	Cancer patients with head and neck cancer; Age greater than 18 years; Programmed to receive radiation therapy; Presence of intact buccal mucosa.	Patients with salivary gland infections or tumors; Patients with Sjögren&apos;s syndrome; Buccal mucosa presenting wounds; Indication for chemotherapy alone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-26cq7n	Effects of antioxidant supplementation Coenzyme Q10 in women with Metabolic Syndrome and liver fat	Recruiting	Intervention	2018-06-21	<NULL>	<NULL>	1921	Effects of Coenzyme Q10 suplementation in women with Metabolic Syndrome and hepatic steatosis: double-blind controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-12	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26cq7n	<NULL>	women; age between 20 and 55 years; sedentary; not menopausal; Body mass index less than 40 kg / m2; carrier of Metabolic Syndrome; with hepatic steatosis.	current gestation / lactation; smoking; alcoholism; inflammatory rheumatologic, intestinal and hepatic diseases; confirmed cancer; polycystic ovary syndrome; confirmed diabetes mellitus (type 1 or 2); refractory arterial hypertension; thyroid disease; use of Ginkgo biloba and statins; Supplementation with vitamin E or CoQ10 in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8sxw2r	Comparison of the analgesic effect between acupuncture and dipyrone in acute tooth pain	Recruiting	Intervention	2018-06-25	<NULL>	<NULL>	1930	Comparative analgesia between acupuncture and dipyrone in acute tooth pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-23	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-8sxw2r	<NULL>	Adult subjects; ages 18-45; of both sexes who are not using any type of pain medication in the last 12 hours with complaint of acute tooth pain of pulp origin equal to or greater than 4 in VAS; non-allergic to dipyrone.	"Patient under 18 years of age; pregnant women; acute tooth pain of less than 4 VAS intensity; toothache of non-pulp origin;
volunteers who are using some type of pain medication; allergic to dipyrone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-8s4gfg	Computer aid to carry out school activities in individuals with Down Syndrome	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1931	Assistive Technology Device for conducting school activities in individuals with Down Syndrome: enhancement of the Augmentative and Alternative Communication	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8s4gfg	<NULL>	present the Informed Consent Form (TCLE); to sign the Free and Informed Consent Term (TALE); to understand the proposed task; able to perform the necessary movement; do not present symptoms of pain or discomfort during the execution of the tasks.	do not understand the task; do not want to perform the movement necessary to perform; have symptoms of pain or discomfort during the execution; limitations of movements in the upper limbs; visual limitation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9kf3nq	Therapeutic value of counseling in the treatment of headache over medication use	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1932	Therapeutic value of counseling in the treatment of headache over medication use	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-08-23	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9kf3nq	<NULL>	Diagnostic of medication overuse headache at first appointment in Oswaldo Cruz University Hospital&apos;s headache clinics	Cognitive deficit witch restricts patient capacity to answer the questionnaires; patients taking analgesics for other type of pain besides headache; secundary headache diagnosis; pregnancy or breast-feeding; opiods overuse; previous tentative of medication overuse&apos;s withdraw; under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-9bhbrp	Changes in oxygenation of skin and muscles after the use of Functional Bandage in women with Varicose Veins	Recruiting	Intervention	2018-06-26	<NULL>	<NULL>	1934	Kinesio Taping use in tissue oxygenation in women with Chronic Venous Insufficiency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-14	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9bhbrp	<NULL>	Must be female, be between 30 and 79 years old and present the diagnosis of chronic venous insufficiency (confirmed by Duplex Scan) or classified in stages C1, C2 or C3 of CEAP. To be included in the study the participants may not be on hormone replacement therapy and may not have symptoms of intermittent claudication, lymphedema, diagnosis of thrombosis for less than three months, heart failure, and no other type of conservative treatment for IVC, or have undergone sclerotherapy or surgery in the past three months. In addition, they can not present any contraindication to the use of KT such as open sores, trauma, edema arising from heart or kidney disease, cancer, KT allergy, and pregnancy. All participants must agree to participate in the research by signing the Informed Consent Term.	Participants who present knesio taping allergy or intolerance will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-26wwhz	Behavior in virtual task of people with Down syndrome	Recruiting	Intervention	2018-06-27	<NULL>	<NULL>	1936	Analysis of virtual task performance in people with Down syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26wwhz	<NULL>	Medical diagnosis of Down Syndrome; cognitive conditions to understand the orientations in relation to the task proposed in each game; and to be able to perform the necessary movement and not present symptoms of pain or discomfort during the execution of the tasks; authorization of the responsible, with the signed free informed consent term and free and informed consent term.	People with cognitive impairments that make it impossible to collaborate and understand simple orders in the proposed activities; Functional deficiencies that impede the accomplishment of the tasks; Withdrawal during the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:18
RBR-3x5c7g	Treatment of Stress Urinary Incontinence in menopause	Recruiting	Intervention	2018-06-27	<NULL>	<NULL>	1939	Clinical study randomized in the treatment of Stress Urinary Incontinence in women in post-menopause	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	SOBEU - Associação Barramansense de Ensino	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-3x5c7g	<NULL>	Age range between 40 and 90 years; minimum period of one year of amenorrhea before the evaluation; without cognitive and or communication problem; who agree to participate in the study according to the informed consent.	Patients less than 40 years and older than 90 years; continents; who have urinary incontinence other than effort; have neurological; visual; auditory; cognitive; oncological; prolapse; intact hymen; vaginal narrowing; vaginal or urinary infection; gynecological uterus; recent gynecological surgery; skin lesions or diseases; allergic processes to the functional elastic bandage or the condom used; musculoskeletal conditions that prevent the performance of the tests and or treatment; being in another physiotherapeutic treatment for the pelvic floor musculature and who refuse to sign the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2m67zd	Comparison the effect of HDx therapy and high flux hemodialysis on endothelium function in hemodialysis patients	Recruiting	Intervention	2018-06-28	<NULL>	<NULL>	1940	A randomized, open-label, crossover, clinical trial to compare the effect of HDx therapy versus high flux hemodialysis on endothelium function in hemodialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Fundação Oswaldo Ramos - Hrim	Fundação Oswaldo Ramos - Hrim	https://ensaiosclinicos.gov.br/rg/RBR-2m67zd	<NULL>	"Male and female aged 18 years old;in hemodialysis program for at least 6 months before the enrollment; with adequate vascular access; hemodialysis 4 hours 3 times/week;
with a result of KtV 1.2 in the 3 months prior to the study and signed the ICF."	Patients with Heart failure III or IV NY class; peripheral arterial disease, previous stroke within the last 3 months before the enrollment; active inflammation or infection disease within the last 3 months before the enrollment; pregnant or lactating female.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8d8rj7	"90/5000
Different devices to interact with virtual environment in people with Multiple Sclerosis"	Recruiting	Intervention	2018-06-28	<NULL>	<NULL>	1941	"Analysis of different interaction devices during a Timing Task
Coincident in virtual environment in people with Multiple Sclerosis"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-19	Universidade  de São Paulo	Associação Brasileira de Esclerose Múltipla	https://ensaiosclinicos.gov.br/rg/RBR-8d8rj7	<NULL>	Multiple Sclerosis diagnosis of recurrent remitting type	Changes in motor functions and pain in the dominant upper limb; during or up to one month prior to data collect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-8bfjgk	Computer Games for Autistic Communication	Recruiting	Intervention	2018-06-29	<NULL>	<NULL>	1946	Virtual Reality and Augmentative and Alternative Communication in Autism	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-10	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8bfjgk	<NULL>	Initially, all the individuals with a diagnosis of ASD; of both sexes; will be included in the study; who will follow up at APAE in Vitória-ES and Vila Velha-ES (for GE) and FMABC Outpatient Neurology; individuals with typical development; paired by age; and gender to the GE; members of the public school Dr. Geraldo José Rodrigues Alckmin in Potim, SP (for the GC).	Individuals who can not understand the orientations in relation to the proposed task; present some limitation of movement of the upper limbs; and / or limitation in visual acuity that prevents them from performing the game; and / or are unable or unwilling to complete the proposed task will be excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-5n4686	Electronic Record for Continuity of Patient Care: A use case for Doctor&apos;s handovers in hospitals.	Recruiting	Intervention	2018-07-02	<NULL>	<NULL>	1947	Electronic Record for Continuity of Patient Care: A use case for Doctor&apos;s handovers in hospitals.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-15	Faculdade de Medicina da Universidade Federal de Minas Gerais	Hospital das Clínicas  Universidade Federal de Minas Gerais - HC-UFMG	https://ensaiosclinicos.gov.br/rg/RBR-5n4686	<NULL>	Eighteen documents of physician handover session before intervention and 18 after the intervention randomly selected for monitoring.	Clinical documents of handover session which physicians do not agree with the voluntary participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-2sv9gw	Determination of the best dose for the electrostimulation of the paravertebral muscles in the force in individuals without chronic low back pain	Recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1950	Determination of the dose-response for the stimulation of the multiphids in the core strength in individuals without chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-04	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-2sv9gw	<NULL>	University students of both sexes; aged between 18 and 40 years; without musculoskeletal disease or lesion in the spine or lower limbs	Uncontrolled systemic diseases, such as diabetes or hypertension; as well as volunteers who report systematic physical activity at least twice a week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-4crf4d	The effect of caffeine on people&apos;s perception of tinnitus	Recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1952	Effect of caffeine intake in tinnitus	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-11	Universidade de Brasilia - UnB	Instituto Brasiliense de Otorrinolaringologia - IBORL	https://ensaiosclinicos.gov.br/rg/RBR-4crf4d	<NULL>	Volunteers who are over 18 years of age and who seek medical consultation with tinnitus	Objective tinnitus, or acute tinnitus, or who have psychiatric and / or cognitive disorders, or alteration of the middle and / or external ear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-95c4rd	Rehabilitation of patients after meniscus surgery	Recruiting	Intervention	2018-07-03	<NULL>	<NULL>	1953	Influence of a rehabilitation protocol and associated or not with the low intensity laser without treatment of patients without post-surgical meniscal lesion	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-17	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-95c4rd	<NULL>	Individuals in the postoperative period of partial meniscectomy of the lateral or medial meniscus; aged between 18 and 60 years, who are referred by the orthopedic sector of the Hospital São Judas Tadeu of the city of Meleiro	Presence of rheumatic, systemic, cognitive; polytraumatized patients that make the execution of the project impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-556d22	Efficacy of Pushing Down Free Compared to Pushing Down With Command in Maternal and Neonatal Outcomes: A Randomized Clinical Trial.	Recruiting	Intervention	2018-07-04	<NULL>	<NULL>	1957	Efficacy of Spontaneous Pushing Compared to Directed Pushing in Maternal and Neonatal Outcomes: A Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-20	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-556d22	<NULL>	Women in the second period of labor; Low- and high-risk gestation; Gestational age between 37 and 42 weeks, between 19 and 45 years.	Twin pregnancy; Gestation with a dead fetus; Induced birth; Use of Oxytocin; Use of psychoactive drugs; Use of pharmacological analgesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:19
RBR-4m6zdh	Behavior of multiple sclerosis patients&apos; view in computer use	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1958	Evaluation of the visual performance of people with multiple sclerosis in the use of tasks in virtual environment	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Escola de Artes, Ciências e Humanidade da Universidade São Paulo	Escola de Artes, Ciências e Humanidade da Universidade São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4m6zdh	<NULL>	All patients with multiple sclerosis; Both sexes; aged between 21 and 80 years; that presents some type of visual deficit except total or partial blindness	Deformity or muscle weakness in the upper limbs that prevent the manipulation of the equipment; outbreak in the last month; surgery or chemical neuromuscular block in the upper limbs in the last two months before participating in the study; presence of disorders in cognitive function and vision that potentially undermine the understanding of the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-6xqrtr	Use of the low-level Laser therapy in the treatment of Inflammation in the lateral region of the knee in women with Femoropatelar Pain	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1959	Use of the low-level Laser therapy in the treatment of inflammation in the Iliotibial Treatment in women with Femoropatelar Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-11	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-6xqrtr	<NULL>	Anterior or retropatellar knee pain when performing at least two of the following activities: sitting for prolonged time, squats, kneeling, running, climbing and descending stairs, and in jumps and landings, present pain during palpation of the patella; have symptoms of insidious onset and lasting for at least 1 month; presenting the worst pain level in the previous month of at least thirty milimeters on the visual analog pain scale (VAS); score below 83 on the Previous Knee Pain Scale (AKPS) questionnaire	Women with a sign or symptom caused by any knee dysfunction; with a recent history of surgery within three months in this joint; history of patellar subluxation or clinical evidence of meniscal injury; ligament instability; osteoarthrosis in any lower limb joint; pathology in the patellar tendon or referred pain from the spine; neurological disease; inflammatory process or have recently undergone physiotherapeutic treatment (at least 6 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-9gh6js	Comparison between two forms of electrical stimulation producing contraction in the force gain of the flexor muscles of the forearm of the non-dominant hand	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1962	Comparison between the Russian current and the Aussie current in the force gain of the flexor muscles of the non-dominant hand	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-20	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-9gh6js	<NULL>	Age range between 18-30 years; female and do not practice regularized physical activities.	History of skeletal muscle dysfunctions prior, acute inflammation in the region to be researched; metallic materials implanted in the arm to be examined; pregnant women; patients with heart disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-7n8vq5	Effects of elastic bands and laser treatment on hand strength with restriction of blood flow	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1965	Influence of elastic bandaging and laser on palmar grip strength in a blood flow restriction protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7n8vq5	<NULL>	Individuals of both sexes; age range between 18 and 30 years; Students of the Federal University of Santa Catarina-UFSC; Only those participants who are able to carry out the proposed activities will be selected.	Individuals with any type of injury to the forearm that compromise the integrity of the musculature; Fractures in the wrist and fingers, with pain in the upper limbs for any reason; obese; hypertensive; cardiopathy; cognitive deficit; manual workers, who do physical activities daily and take medication that interferes with the final results of the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-4fyhhy	Muscle Contraction during Hip strengthening Exercises	Recruiting	Intervention	2018-07-05	<NULL>	<NULL>	1966	Comparison of the Activity of the Middle Buttock Muscles and Tensor of the Fascia Lata, during Exercises to Strengthen the Lateral Region of the Hip	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2017-07-16	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4fyhhy	<NULL>	Be between the age group between 18 and 30 years; women; with and without complaints of pain in the patellar femoral joint; the characterization of the sample will be through IPAQ, with individuals classified as sedentary or moderate.	Individuals with the IPAQ score equal to vigorous; presence of fractures in the last 6 months; muscle lesions or some rheumatologic pathology.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-2yzs76	Multidisciplinary Program of Treatment of Obesity: Evaluation of Cardiometabolic Risk Factors	Recruiting	Intervention	2018-07-06	<NULL>	<NULL>	1974	Effectiveness of a Multidisciplinary Program in Evaluation of Cardiometabolic Risk Factors and Treatment of abdominal Obesity in two cities in the Northwest of Paraná	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-20	Universidade Estadual de Maringá	Universidade Estadual do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2yzs76	<NULL>	Age between 18 and 50 years; Being overweight or obese, from cutting index points Body mass index greater than or equal 25; Waist circumference greater than or equal 88 cm for women and greater than or equal 102 cm for men; Be resident in Maringa or Maringá metropolitan area; Present willingness to participate in the evaluations of the risk cardiometabólico; Agree and sign the informed consent approved by the local Ethics Committee.	"Recent abdominal surgery or Bariatric Surgery;
Pulmonary disease with oxygen dependence; Hospitalization for treatment of cardiovascular diseases in the last 6 months; Aortic stenosis;
Being pregnant or have less than 3 months post partum; Use of medicines for weight loss; Using glicocorticoides;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:20
RBR-8xt8wx	Root canal treatment in primary molars with necrotic pulp using two different pulp therapies	Recruiting	Intervention	2018-05-21	<NULL>	<NULL>	1977	Pulp therapy in necrotic primary molars using CTZ paste and Zinc Oxide-Eugenol paste - a randomized controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-06-04	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8xt8wx	<NULL>	Lower primary molars with clinical and / or radiographic history of pulp necrosis. Crown with sufficient dental structure to be restored with stainless steel crown. Rhizolysis equal to or less than 1/3	Teeth that present calcium metamorphosis. Pathological root resorption. Coronary destruction that makes it impossible for the tooth to be restored. You have been using antibiotics for the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3sqsh8	Evaluation of the inflammation and effects of dental denture during orthodontic treatmen	Recruiting	Intervention	2018-07-09	<NULL>	<NULL>	1978	Evaluation of inflammatory activity and efficacy of dental bleaching during orthodontic treatment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-11	Centro Universitário do Maranhão	Centro Universitário do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3sqsh8	<NULL>	Patients aged between 18 and 40 years will be included; who agree and sign the informed consent form (TCLE); with good oral health in general, with the presence of all upper teeth up to the first molar with vitality, free of caries lesions; and may have satisfactory aesthetic restorations, proven by periapical radiographs that do not involve the middle third of the dental crown; without cervical lesions (abrasion, erosion and abduction); absence of periodontal disease; have not undergone periodontal treatment within 3 months prior to the start of the study; do not present clinical signs of gingivitis and do not have systemic disorders that interfere with the periodontal condition, prior to the installation of the device; non smokers; have not undergone previous orthodontic treatment; have not used antibiotics in the 3 months prior to the study; not being on systemic medication; the initial color of the teeth should be A2 or darker by comparison with the Vita Classic scale (Vita Zahnfabrik, Bad Säckingen, Germany) organized in order of value	The study will exclude patients who had undergone tooth whitening treatment in the last 12 months; with caries, cervical lesions; pregnant or lactating women; root canal treatment; patients with restorations at buccal surface or dental prosthesis on the teeth; gingival recessions; parafunctional habits; patients who were taking medications with an analgesic or anti-inflammatory effect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-387v6v	Influence of the dietary period (with restriction versus time restriction) on body composition, resting metabolic rate, hunger sensation, insulinemia, leptinemia and thyroid function of obese women submitted to diets with the same energy deficit.	Recruiting	Intervention	2018-01-19	<NULL>	<NULL>	1983	Influence of the dietary period (with restriction versus time restriction) on body composition, resting metabolic rate, hunger sensation, insulinemia, leptinemia and thyroid function of obese women submitted to diets with the same energy deficit.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Alagoas	Centro de Recuperação e Educação Nutricional	https://ensaiosclinicos.gov.br/rg/RBR-387v6v	<NULL>	Women; adults (19-44 years old); obese (defined as a Body Mass Index&gt; 30 kg / m²); who are willing to lose weight; who have been weight-stable for at least 1 month at the time of inclusion.	individuals using chronic medicine (anti-diabetic, antihypertensive, antiretroviral, immunosuppressive, diuretic); with a pacemaker; that present edema and/or ascites; pregnant or lactating and has not performed any surgical intervention for weight management.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3jj84f	Hygiene of total dentures in patients leaving in home care facilities	Recruiting	Intervention	2018-07-10	<NULL>	<NULL>	1984	Controled randomized clinical trial of hygiene of complete dentures in institutionalized patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3jj84f	<NULL>	60 years of age or older; complete edentulism; use of a conventional upper complete denture in acrylic resin for at least one year	The wear of conventional upper fractured, repaired or relined upper dentures; being in use or having used antibiotics, antifungals or corticosteroids for a period of three months prior to the study; using denture adhesives; being a smoker; using of prostheses with excessive accumulation of calculus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-4pt72m	Combination of physical exercises and training in video games for post stroke people	Recruiting	Observational	2017-01-24	<NULL>	<NULL>	1987	Combination of multimodal physical exercises in real and virtual environments for individuals after chronic stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-10-15	Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4pt72m	<NULL>	Chronic phase stroke; territory of the Cerebral Media or in the Anterior Cerebral Artery; both types of stroke (ischemic and hemorrhagic); cognition greater than 24 points in the Mini Mental State Examination; to less than 2 months of use in forms and the Wings of Empowerment with physical exercises; (community) and without experience in Virtual Reality games.	Individuals with any type of cardiovascular complication that would contraindicate physical exercise; who underwent surgeries to attenuate clinical conditions resulting from stroke; that had a chemical blockade to reduce spasticity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-83qw93	Evaluation of postoperative bleeding of oral surgeries in patients taking oral anticoagulants.	Recruiting	Intervention	2018-07-10	<NULL>	<NULL>	1988	Postoperative oral surgery bleeding in patient using anticoagulants: clinical randomized study.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-08	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-83qw93	<NULL>	Patients taking oral anticoagulants for at least 14 days; patients with indication of small oral surgeries; patients with INR (International Normalized Norm) between 1.5 and 4.0 the day before the procedure.	Patients with blood dyscrasia or other conditions that alter blood clotting; patients smokers; diabetic patients; pregnant or lactating patients; patients with a history of allergy to tranexamic acid or reabsorbable collagen gelatin; patients using medications that may interact with medications used in this study; oral surgeries that last 40 minutes; oral surgeries with large osteotomies (third molars included and impacted); patients with INR above 3.5	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-66jx3m	Effect of resistance training on balance and muscular strength of the elderly	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1991	Assessment of the balance and muscular strength of the elderly before and after resistance training: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-09	Universidade Federal do Pampa	Universidade Federal do Pampa	https://ensaiosclinicos.gov.br/rg/RBR-66jx3m	<NULL>	"Volunteers of both genders, aged 60 or
over, ability to stand and walk
independently"	"Volunteers who have any type of
amputation, no independent gait, body mass index (BMI) below 18.5 kg / m2; have been engaging in physical activity in the past 6 months
uninterrupted; hypertensive or with blood pressure values greater than 180mmHg
systolic and diastolic blood pressure
90 mmHg"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:21
RBR-3zjn27	The efficacy of Pharyngeal Packing during adenotonsillectomy in children	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1993	The efficacy of hypopharyngeal packing during adenotonsillectomy in children in the prevention of postoperative nausea and vomiting.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-28	Irmandade Santa Casa de Misericórdia de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-3zjn27	<NULL>	"Children aged between 4 and 12 years old;A
adenotonsillar hipertrophy; adenotonsillectomy indication for treatment of Apnea Obstructive Syndrom ou Recurrent Tonsilitis, caregiver able to give informed consent and to complete de Patient Diary reliably."	Patients with hematopoietic, cardiovascular, hepatic, kidney, neurological, psychiatric, autoimmune disease; patients that feel unable to complete the Patients´Diary.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-5t582g	Comparison of Body warming devices and clinical outcomes after Heart Surgery: randomized Clinical Trial	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1995	Comparison of Cutaneous Warming Devices and clinical outcomes in the postoperative period in Cardiac Surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-5t582g	<NULL>	Age 18 years or older; submitted to elective coronary artery bypass grafting with Cardiopulmonary bypass;  Intensive Care unit admission temperature below 36 ° C and greater than 32 ° C.	Other surgical corrections associated with coronary artery bypass grafting with Cardiopulmonary bypass; use of circulatory support devices, intra-aortic Balloon Counterpulsation; extracorporeal membrane oxygenation ; ventricular percutaneous circulatory assistance previus cardiac surgery; patients with chronic renal disease; intraoperative cardiac arrest, immunosuppressed patients; acquired or hereditary coagulation disorders; liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-5fsg97	Effects of integrative therapies in health, quality of life and wellness of breast cancer women and prostate cancer men	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1997	Effects of the Brazilian integrative wellness protocol for cancer care on quality of life, wellness, and biopsicosocial factors of breast cancer women and prostate cancer men	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-11	CREMIC - Centro Estadual de Referência em Medicina Integrativa e Complementar	CREMIC - Centro Estadual de Referência em Medicina Integrativa e Complementar	https://ensaiosclinicos.gov.br/rg/RBR-5fsg97	<NULL>	Breast cancer women; prostatic cancer men; adults; in any cancer and treatment stage.	Open lesions or  wounds; recent surgeries (less than thirty days); severe immunodeficiency ( neuthrophil count less than 500 cells per / ml).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-4h2cr6	Exercises to improve shoulder movement Individuals with Shoulder Dysfunction	Recruiting	Intervention	2018-07-11	<NULL>	<NULL>	1998	Efficacy of an Exercise program for Scapular Dyskinesis in individuals with Shoulder Impact Syndrome	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4h2cr6	<NULL>	Individuals diagnosed with shoulder impact syndrome; Individuals who present scapular dyskinesis identified in the dynamic exam of upper limb flexion using the simple &apos;yes&apos; or &apos;no&apos; test; Aged between 18 and 50 years; Neer positive test; Hawkins Kennedy positive test;	Have surgery on the shoulder; Neoplasms or infections; Neurological disorders;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-7528x4	Comparison of the effect of Hypnosis and Electrostimulation on pain control in patients with Chronic Low Back Pain	Recruiting	Intervention	2018-07-12	<NULL>	<NULL>	1999	Comparison of the effect of two analgesic techniques on pain control in patients with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-11	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7528x4	<NULL>	Chronic low back pain	are performing physiotherapeutic treatment by electroanalgesia, regardless of the current used; having a cardiac pacemaker; pregnant women; individuals who have performed surgical procedures in the spine; individuals who use analgesic drugs twenty-four hours (24 hours) before the interventions; individuals who present contraindication to cold	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-25w6kk	Exercises to improve posture,flexibility and quality of life in1o to 13 year-old females	Recruiting	Intervention	2018-07-13	<NULL>	<NULL>	2005	The comparison of the effect of Holistic Gymnastics, Eutonia and Pilates on posture, flexibility and quality of life of children between 10 and 13 years old	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-13	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-25w6kk	<NULL>	"Age between 10-13 years;
Female gender;
Tosign the informed Consent Form (ICF)"	"sequel of orthopedic, rheumatic or neurological disease;
use of prosthetic limbs;
pain during practice of physical activities"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-9nt9hv	Text Messages to improve HIV Antiretroviral Therapy Compliance	Recruiting	Intervention	2018-07-13	<NULL>	<NULL>	2007	The use of Text Messages in adherence to Antiretroviral Treatment	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-11	Universidade Federal de Santa Maria	Hospital Universitário de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-9nt9hv	<NULL>	The inclusion criteria for participation in the study will be: people infected with HIV and on antiretroviral treatment; Be on medication for at least 3 months; (15 years or older), according to UNAIDS criteria.	"The exclusion criteria will be: to present some cognitive and mental limitation (which impairs comprehension and / or verbal expression); To be in prison, a
Access to mobile phones; Not knowing how to read if the person does not use tools that allow the reading of the message, since the intervention will be carried out by means of a text message; Women in the gestational period, since there is evidence that during this period there is an increase in adherence."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-8dqrdq	Training of respiratory muscles on functional variables and cardiac function in patients undergoing a bypass graft	Recruiting	Intervention	2018-07-16	<NULL>	<NULL>	2010	Individualized inspiratory muscle training on functional and ecocardiographic variables in patients submitted to myocardial revascularization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Instituto Nobre de Cardiologia	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-8dqrdq	<NULL>	Age between 30 and 60 years; Both genders; Undergoing myocardial revascularization, this procedure being done via median sternotomy and extracorporeal circulation.	Do not understand how the proposed techniques are performed; Have hemodynamic instability during inspiratory muscle assessment or training; Physical limitation, such as amputation, that compromises functional capacity assessment; Change in cognitive ability, assessed through the Confusion Assessment method for the ICU (CAM-ICU), to answer the questionnaires; Impossibility of echocardiogram repetition by the same physician; They did not agree to sign the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-2pcrzy	Restorative treatments for teeth with Hipomineralization of Molars and Incisors	Recruiting	Intervention	2018-07-16	<NULL>	<NULL>	2011	Therapeutic modalities in Hipomineralization of Molars and incisors: A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-05	Universidade Federal do Paraná	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2pcrzy	<NULL>	Children residing in the municipality of Curitiba; present first permanent molars hypomineralization of molars and incisors MIH.	present fluorosis; tooth that requires endodontic treatment; children with orthodontic appliance; impossibility of absolute isolation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:22
RBR-92sp94	Physiotherapy for pregnant women	Recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2015	"Pregnant Healthy:
physiotherapeutic attention to pregnant woman in primary care"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-30	Universidade do Estado do Pará	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-92sp94	<NULL>	Pregnant women with ages ranging from 18 to 40 years. Between the 9th week and 32 weeks of gestation. Do prenatal care at the school&apos;s health center	Pregnant women who have some gestational risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-3xbnnn	Endodontic treatment versus retreatment: inflammatory and microbiological evaluation, before during and after 18 months of treatment	Recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2018	Primary versus secondary endodontic infection: inflammatory and lipid profile, microbial profile, endotoxin and LTA levels before and during endodontic therapy and success after 18 months of treatment	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2017-07-12	Universidade Estadual Paulista Júlio de Mesquita Filho - Campus São José dos Campos	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3xbnnn	<NULL>	Patients in adulthood; Need for endodontic treatment; Permanent teeth with primary endodontic infection; Unirradicular; Presence of a single canal and periapical lesion; Absence of periodontal pockets greater than 4 mm; No mobility.	Teeth that can&apos;t be insulated with the rubber dam; With root fracture; Exposure of the pulp chamber; Patients who have used antibiotics or antifungals in the last 3 months; Patients with systemic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-2t3hfv	Evaluation of the Efficacy of Transcranial Direct Current Stimulation in the Treatment of Cognitive Symptomatology in the Early Stages of Psychosis	Recruiting	Intervention	2018-07-17	<NULL>	<NULL>	2019	Evaluation of the Efficacy of Transcranial Direct Current Stimulation in the Treatment of Cognitive Symptomatology in the Early Stages of Psychosis: Study Protocol of a Double-blind Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-16	Universidade Federal de Sao Paulo - UNIFESP	Universidade Federal de Sao Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-2t3hfv	<NULL>	Subjects of both genders, diagnosed with schizophrenia in early stage psychosis (first five years of illness), confirmed through the Structured Interview of the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders - 5th edition (SCID-5); aged 18-60 years; minimum of 4 years of education;  Intelligent Quotient (IQ) from low average to higher scores (IQ&gt;70); and the subjects should be receiving stable doses of antipsychotics for at least four weeks (antipsychotic dose stability criterion).	(1) presence of a history of cranioencephalic trauma with loss of consciousness with a time greater than 5 minutes; (2) history of central nervous system diseases that affect the brain; (3) unstable clinical conditions; (4) use of drugs that affect cognitive performance such as benzodiazepines and anticholinergic agents; (5) current diagnosis of substance abuse; (6) history of substance dependence in the last 6 months, except nicotine addiction; (7) current diagnosis of another Axis I condition, confirmed through SCID-5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-39czsv	Comparison between Therapeutic Ultrasound and Anesthesia Injection in women with Tummy Pain caused by a pain point for more than 6 months	Recruiting	Intervention	2018-07-18	<NULL>	<NULL>	2025	Therapeutic Ultrasound and Local Anesthetic Injection in the treatment of women with Chronic Pelvic Pain secondary to Myofascial Abdominal Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-15	Faculdade de Medicina de Ribeirão Preto - FMRP-USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP - HCFMRP	https://ensaiosclinicos.gov.br/rg/RBR-39czsv	<NULL>	Women older than eighteen years and not menopausal with clinical diagnosis of abdominal myofascial syndrome with presence of only one active trigger point and pain above four point four (moderate pain) in the visual analogue scale (VAS) and without previous treatments.	Pregnant women with hip prosthesis, neoplasias in the abdomino-pelvic region, with severe osteoporosis, copper IUDs, abdominal varicose veins, cognitive deficits that make the questionnaires difficult to comprehend, women with anticoagulation or hemorrhagic disorders, local or systemic infections, allergy to anesthetics, acute muscle trauma, extreme fear of needles, history of complaints of chronic musculoskeletal pain such as fibromyalgia, chronic fatigue or diabetes. Also included in the exclusion criteria are those who use chronic painkillers, anti inflammatories, and tricyclic antidepressants who have used aspirin within three days prior to injection, all patients with suspected interstitial cystitis, bowel syndrome irritable or other disease that justifies or contributes to CPP, will also be part of the criteria for exclusion of endometrioma or hernia evidenced by ultrasound of the abdominal wall, abdominal wall infections and women who are missing after the start of treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:23
RBR-6wzmwx	Effects of Ice and Electrical Current on patients with partial loss of movement and muscle stiffness	Recruiting	Intervention	2018-07-20	<NULL>	<NULL>	2038	Effects of Chryotherapy and Neuromuscular Electrical Stimulation in Spastic Hemiparetic patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-12	SOBEU - Associação Barramansense de Ensino	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-6wzmwx	<NULL>	Patients in the chronic phase of stroke (at least 3 months after injury); have a maximum grade 3 and minimal degree +1 spasticity according to the Modified Ashworth scale; medical indication for physical therapy; adequate understanding and communications competencies; agree to be part of the study in accordance with the authorization of free and informed consent	Patients younger than 45 and older than 90 years who present with Raynaud&apos;s disease; thromboangiitis obliterans; cryoglobulinemia; cold urticaria; uncontrolled hypertension; sensory deficiency; cold aversion; spasticity grade 4 according to the modified Ashworth scale; aphasia or Wernick&apos;s dysphasia; trophic changes at the site of electrical stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-4hm7mz	Effect of fortification with powder nutrients in prevention and treatment of nutrient deficiency	Recruiting	Intervention	2018-07-23	<NULL>	<NULL>	2039	Effectiveness of fortification with powder micronutrients in prevention and treatment of micronutrient deficiency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-09	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4hm7mz	<NULL>	Children aged six to 48 months; anemic and non-anemic.	Children in treatment of anemia; malaria; HIV, hemoglobinopathies or hemochromatosis; low weight at birth; preterm birth (less than 37 weeks); twin; allergies reported to any components of the fortification sachet and/or to ferrous sulfate/folic acid.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5j3h3c	Comparison between 2 and 5 minutes of  stretching in the calcaneus tendon	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2044	Comparison between 2 and 5 minutes of passive static stretching in the mechanical properties of the calcaneus tendon in young adults: a clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5j3h3c	<NULL>	Be between 18 and 40 years old;To be physically active, but not engaged in strength training and flexibility according to the classification of the International Physical Activity Questionnaire (IPAQ)	Do not compare with evaluations (pre or post);Withdraw your consent;Have two consecutive fouls or three interspersed without a stretching program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-7cp49x	Effect of a Strength and Resistance Training protocol on Heart Variability in patients with kidney disease who are not on hemodialysis	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2046	Effectiveness of a Strengthening and Aerobic Training protocol on Heart Rate Variability in Predialytic patients: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7cp49x	<NULL>	Stages 4 and 5 non-dialysis chronic kidney disease patients; between 18 and 60 years old; from both sexes; using no medication that alters the autonomic nervous system	Patients in the following conditions will be excluded from this study those who participated in an intervention program less than three months ago; or presenting unstable arterial hypertension with diagnosed by a physician; amyloidosis; congestive heart failure; acute infarction; myocardial infarction (up to three months); unstable angina; osteoarticular abnormalities that make it impossible for them to execute the exercise protocols; peacemaker users and those who underwent heart transplantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-38nfg2	Effect of supplementation of vitamin and the serum and milk of breastfeeding women	Recruiting	Intervention	2018-07-24	<NULL>	<NULL>	2047	Effect of supplementation with 800 IU of vitamin E on serum alpha-tocopherol and milk of lactating women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-18	Departamento de Bioquímica da Universidade Federal do Rio Grande do Norte	Departamento de Bioquímica da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-38nfg2	<NULL>	Women 30 to 60 days postpartum who are in the waiting room of the ambulatory care and breastfeeding their child; residents of Natal, state of Rio Grande do Norte; without diagnosis of diseases such as hypertension, diabetes, neoplasias, cardiopathies, diseases of the gastrointestinal and hepatic tract, syphilis, HIV positive; non-smokers and who had deliveries with a single concept and without malformation.	Women who do not have milk; illicit drug users who use vitamin E vitamin supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-83kysp	Acute Effect of Full-Body Vibration in Women with Fibromyalgia	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2053	Acute Effect of Full-Body Vibration Stimulation in Women with Fibromyalgia	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Fundação De Amparo a Pesquisa de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-83kysp	<NULL>	Women aged 35 to 70 years; with confirmed diagnosis of fibromyalgia between 1 and 3 years; presence of sensitivity in at least 11 of the 18 specific pain points according to the American College of Rheumatology criteria.	Volunteers who present; any concomitant illness that may be exacerbated by physical activity; pregnancy; orthopedic limitations; inflammatory diseases; degenerative diseases; articular; respiratory or cardiovascular diseases; who are being followed up with a psychiatrist; who perform physical activity for the same 2 times a week; (acute hernia, thrombosis, diabetes, epilepsy, metabolic or neuromuscular diseases, orthopedic injuries and prosthetics); use immunosuppressive medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5hq3xh	The practice of Pilates exercises associated with Buteyko exercises in children and adolescents with asthma	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2055	Effects of the application of the Pilates method and combination with the Buteyko method in children and adolescentes asthmatics	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-08	Universidade Federal de Pernambuco	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-5hq3xh	<NULL>	"Patients of both sexes;
Age from 7 to 15 years;
Pacients with persistent asthma
moderate and severe;
In outpatient follow-up
regular."	"Volunteers who had episodes of recent respiratory infections (less than 30 days);
Cardiovascular, orthopedic and rheumatologic diseases;
Non-performance of lung function tests;
Absences from sessions (25% or more)."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-63hk5w	Biotin 2.5mg oral and Minoxidil 5% increase the speed of growth of the nails of the hands in healthy adults.	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2056	Evaluation of nail growth: comparison between Biotin and topical Minoxidil	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-22	UNESP - Universidade Estadual Paulista	UNESP - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-63hk5w	<NULL>	Healthy men and women; 18 to 65 years	Pregnant; infants; active smokers; active alcoholics;cutaneous or systemic pathology influencing nail growth; drugs established in the literature that alter nail growth; allergy to minoxidil or biotin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:24
RBR-5pg989	Assessment and treatment of shoulder Pain	Recruiting	Intervention	2018-07-25	<NULL>	<NULL>	2059	Assessment and intervention of shoulder Dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-20	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5pg989	<NULL>	"Category 1 volunteers will be included, adults 18 and older, of both sexes; patients with shoulder pain associated with range of motion limitation; we will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; non-athletes or regular physical activity practitioners who perform aerial launch movements; pregnant or reporting pregnancy will not be included; Acceptance in the Informed Consent Form.

Category 2 volunteers will be included, adults 18 and older, of both sexes; patients with shoulder pain associated with range of motion limitation; we will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; athletes practicing regular physical activity that perform aerial launch movements; Acceptance in the Informed Consent Form.

Volunteers will be included for category 3, adults over 18 years of age, female; volunteers with complaints of wrist and hand pain with irradiation in the upper limb diagnosed as compressive syndrome will not include patients diagnosed with cervical hernia, cervical stenosis, cervical spine degenerative diseases, cervical spine arthrodesis and Benign Paroxysmal Positional Vertigo; non-athletes or regular physical activity practitioners who perform aerial launch movements; pregnant or reporting pregnancy will not be included; Acceptance in the Informed Consent Form."	Participants who do not attend the reevaluations, do not carry out the proposed home protocol will be excluded; failure to complete the questionnaires; unable to perform the proposed exercises on the first day of the assessment; discomfort during the performance of exercises such as dizziness and nausea.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-5qwkqd	Effects of bed bath on physiological changes: randomized clinical trial	Recruiting	Intervention	2018-07-26	<NULL>	<NULL>	2063	Effects of bag bath and bed bath on oxi-hemodynamics changes: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-13	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5qwkqd	<NULL>	Admitted to the Intensive Care Unit studied; have an age of 18 years or more; be submitted to  procedure bed bath for purposes of promoting comfort and / or body hygiene.	patients with medical diagnosis of neurological alterations that compromise the regulation of body temperature and burns of great extent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-6xmd7x	Effect of Fluoxetine on skin coloration in patients with vitiligo: a clinical study	Recruiting	Intervention	2018-07-27	<NULL>	<NULL>	2064	Effect of Fluoxetine in pigmentation of the skin in Vitiligo carriers: clinical study	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2018-07-30	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6xmd7x	<NULL>	Have a diagnosis of segmental or non-segmental vitiligo by dermatologist;be at least 18 years old;have 3 to 50% of the area of the affected body surface	Be carrying out any method of treatment for at least three months, those with any autoimmune disease, patients with more than 50% of the body surface affected, pregnant or lactating women, patients with skin cancer, patients with psychological disorders, patients with photosensitive conditions, vitiligo limited only to the genitals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-67cjv5	Clinical study in the treatment of menstrual cramps	Recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2069	Randomized clinical trial in the treatment of primary dysmenorrhoea syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-11	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-67cjv5	<NULL>	Accept signing the free and informed consent form; age between eighteen and thirty-five years; pelvic pain caused by primary dysmenorrhea; first to the third day of the menstrual cycle; between one and ten on the analogue visual pain scale	Age less than eighteen and over thirty-five years; patients taking analgesics and other therapies for pelvic pain; gynecological pathologies; undiagnosed abdominal pain; patients with cardiac pacing; cardiac complications; degree 0 on the visual analogue pain scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3b69nt	The use of Pain Medicines after Primary Teeth Extractions: from Prescription to reality	Recruiting	Observational	2018-07-30	<NULL>	<NULL>	2070	The use of Analgesics after Primary Teeth Extractions: from Prescription to reality	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-30	Universidade Federal de Santa Maria/Pró Reitoria de Pós Graduação e Pesquisa	Universidade Federal de Santa Maria/Pró Reitoria de Pós Graduação e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-3b69nt	<NULL>	parents or guardians of children who have undergone primary tooth extraction	Parents or guardians of children who have undergone exodontia of embedded, ankylosed, fused or removed teeth without the use of local injectable anesthesia will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-7m4v7b	Evaluation of the use of Ranitidine in diabetic patients with severe infection (sepsis)	Recruiting	Intervention	2018-07-30	<NULL>	<NULL>	2071	A phase II randomized, double-blind, placebo controlled study of the safety and efficacy of ranitidine in diabetic patients with severe sepsis and septic shock.	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2014-04-02	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7m4v7b	<NULL>	Patient with age greater than 18 years; Admitted to the Emergency Unit of Clinical Hospital of Ribeirão Preto medical school of University of São Paulo (UE-HCFMRP/USP);  diagnosis of diabetes mellitus or serum glucose &gt; 200 mg / dL at the admission; diagnosis of severe  sepsis or septic shock; ability of the patient or his or her legal representative to decide whether or not to participate in the survey before completing 48 hours of admission.	Septic Patients who do not have the criteria for severe sepsis or septic shock; continuous use of  ranitidine or other H2 antagonist; hypersensitivity to ranitidine or other H2 blockers; pregnant women; participation in another study; diagnosis of HIV; realization of chemotherapy in the last 30 days; palliative care; lymphoproliferative disease; refusal to signing the consent form (CF) or not to participate in the study; need of procedure or examination with contrast which requires the use of ranitidine as premedication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-3m7fdv	Effect of individual and group exercise on pain and fatigue caused by cancer	Recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2075	Effect of individual or collective kinesiotherapy on pain and oncological fatigue	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-20	Universidade Federal de Sergipe	Associação de Amigos da Oncologia	https://ensaiosclinicos.gov.br/rg/RBR-3m7fdv	<NULL>	Anatomopathological diagnosis of breast cancer; radical or total mastectomy surgery; have or have not had adjuvant chemotherapy; removed from the drain; have up to four months of performing the surgical procedure; surgical incision healed.	Malnutrition; metastasis; lymphedema; bilateral breast cancer; immediate breast reconstruction; had adjuvant radiotherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-7qk2cs	Transcranial current stimulation in patients undergoing hemodialysis	Recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2076	Transcranial Direct Current Stimulation and its therapeutic potential in patients undergoing Hemodialysis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-15	Universidade Federal do Rio Grande do Norte	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qk2cs	<NULL>	Age between 18 and 75 years; previous medical evaluation with clinical diagnosis of depression, anxiety, chronic pain and pressure lability and being on hemodialysis treatment	Evidence of any cognitive deficit (senile dementia, Alzheimer&apos;s); presence of physical and / or organic difficulties; individuals with severe cardiovascular risk or hemodynamically unstable; history of seizures or epileptic disease; pregnancy; metallic implants in the head or neck and cardiac pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-6fyh2c	The effect of health education on the patient with chronic pain	Recruiting	Intervention	2018-07-31	<NULL>	<NULL>	2077	Effect of a health education program on individuals with chronic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-10	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-6fyh2c	<NULL>	Individuals enrolled in the health teams of the Pituaçu family health units and Pituaçu Park; daily or near-daily pain for at least six months; between the ages of 18 and 60; who were literate.	Pregnant women; people with difficulties to understand the questionnaires; associated diseases that can reduce the level of quality of life;functional illiteracy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-8sk5j9	Validation study of the AGE-Reader device (Trade Mark) in the Brazilian population with or without kidney diseases	Recruiting	Intervention	2018-08-01	<NULL>	<NULL>	2079	Validation study of the AGE-Reader (Trade Mark) in a sample of the Brazilian population with and without chronic kidney disease	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Serviço de Nefrologia do Departamento de Clínica Médica da Faculdade de Ciências Médicas (FCM) da Universidade Estadual de Campinas (UNICAMP),	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8sk5j9	<NULL>	"Control group: Will include 300 individuals with age greater than or equal to 18 years; with Fitzpatrick skin phototype I to IV; no history of Diabetes Mellitus and Chronic Renal Disease or smoking.

Chronic Kidney Disease Group (CKD): 300 patients with CKD according to the criteria of Kidney International Disease Improvement Global Outcome (KDIGO) and treated at the HC-FCM-UNICAMP Nephrology Service; 75 of them in stage 3B of CKD, 75 in stage 4 or 5 non-dialytic of CKD, 75 on hemodialysis, and 75 on peritoneal dialysis; with age greater than or equal to 18 years. Patients with DM or smokers will not be excluded."	"Control Group: Individuals aged younger than 18 years; with Fitzpatrick skin type VI to VI; with a history of Diabetes Mellitus and smoking; and individuals who do not agree with the terms set forth in the Free and Informed Consent Term will be excluded.

Chronic Kidney Disease Group: Individuals aged younger than 18 years; with a Fitzpatrick skin V to VI phototype; individuals who do not agree with the terms set forth in the Free and Informed Consent Term will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:25
RBR-5n9cmf	Evaluation of the effect of Compression Stocking containing Natural Product in the treatment of Ulcers and Varicose Veins	Recruiting	Intervention	2018-08-01	<NULL>	<NULL>	2082	Clinical study randomized, blind, controlled of effect of compression Stocking containing nanoencapsulated Flavonoid in the treatment of chronic venous Insufficiency	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-17	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5n9cmf	<NULL>	Volunteers with varicose veins, varicose veins plus edema, hyperpigmentation, lipodermatosclerosis, healed venous ulcer or active ulcer; age between 30 and 59 years; both genders; similar impairment of the saphenous vein	Volunteers with telangiectasias; cognitive alterations; diabetics; neuropaths; with erysipelas; lymphangitis; deep vein thrombosis; ulcer of non-venous origin; psychiatric disorders; demence; without speaking or understanding the Portuguese language; use of antibiotic or venoactive drugs in the last six months prior to the start of the research; sclerotherapy of lower limbs; surgical procedure; use of Unna boot, multi-layer dressing or dressing with topical medicine; children; morbidly obese; pregnant women; infants; patients at risk of pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7dfwct	The effect of auriculotherapy and mechanical vibrations generated on oscillating vibratory platform in individuals Knee arthrosis	Recruiting	Intervention	2018-08-02	<NULL>	<NULL>	2083	Research on the effect of a procedure involving the association one of the Integrative and Complementary Practices (auriculotherapy) in the “Sistema Único de Saúde” and the mechanical vibrations generated in oscillating/vibratory platform in the manangement of individuals with a chronic non-communicable disease (Gonarthrosis)	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2013-10-05	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7dfwct	<NULL>	Individuals over 18 years of age with Knee osteoarthritis or healthy (no chronic diseases or lesions in lower limbs).	individuals who are taking viscossupplementation and / or corticoids less than 12 months old; individuals currently in another rehabilitation program; individuals with clinical manifestations that did not allow the accomplishment of exercises; individuals with presence of cardiac pacemaker; individuals with recent surgeries in the lower limbs (1 year), individuals with hip or bilateral knee arthroplasty, individuals with rheumatoid arthritis and / or spinal arthrodesis; individuals who refused to sign the Informed Consent Term (TCLE).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-56n3sc	Relationship between the value of suppression of the Bispectral Index and cerebral oximetry through the skin in the occurrence of delirium in cardiac surgery	Recruiting	Intervention	2018-08-02	<NULL>	<NULL>	2086	Correlation of bispectral index suppression index with transcutaneous cerebral oximetry in the occurrence of delirium in cardiac surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-07	Sociedade Literária e Caritativa Santo Agostinho	Sociedade Literária e Caritativa Santo Agostinho	https://ensaiosclinicos.gov.br/rg/RBR-56n3sc	<NULL>	"Physical state ASA II or III;
Patients over 50 years of age;
Elective cardiac surgery with CPB;
Informed consent signed by the patient"	"History of previous stroke;
Degenerative disease of the central nervous system; Mini-mental and / or MoCA &lt;24;
Emergency / emergency surgery;
Patient refusal to participate in the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-4tmcrk	Evaluation of the precision of the guided surgery in the installation of implants	Recruiting	Intervention	2018-08-03	<NULL>	<NULL>	2089	Evaluation of the influence of guided surgery on the precision of positioning of single implants in post extraction sockets in the anterior region - Prospective randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4tmcrk	<NULL>	Over 18 years of age; good oral hygiene (plate index &lt;20%); present indication for installation of immediate unitary implants in the anterior region of the maxilla; indication of caries extraction or root fracture; remaining adequate bone levels for installation of unitary implants; present intact neighboring teeth to the area that will receive the implants.	Need for previous surgery to increase bone and / or soft tissue; patients with periodontal disease; patients with top bite or with loss of posterior occlusal support, patients with diseases or systemic conditions or who use drugs that alter bone metabolism; presence of fixed orthodontic appliances, pregnant or lactating women; heavy smokers (Above 10 cigarettes per day).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-3qnh96	Clinical trial of facial paralysis treatment.	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2091	Randomized clinical trial without treatment of peripheral facial palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-13	Centro Universitário de Barra Mansa	Centro Universitário de Barra Mansa	https://ensaiosclinicos.gov.br/rg/RBR-3qnh96	<NULL>	Participation of this study patients with medical indication for physical therapy; being in the chronic phase of the PFP with a minimum of 3 months after the injury; of different etiologies; presenting facial muscle dysfunction from Grade II to VI according to the House-Brackmann scale and who agree to be part of the independent study of the therapeutic resource that will be used.	Patients with a diagnosis of PF presenting grade I dysfunction according to the House-Brackmann scale will be excluded from the present study; which are in the initial phase of the disease and have hypersensitivity to phototherapy; skin irritation; eye problems; bacterial processes. Also excluded are patients with bilateral facial involvement and lesions or coarse facial features that may interfere with electrode contact and laser irradiation; with lack of understanding and who are performing other facial treatments simultaneously.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-2njhwn	Impact of stomach reduction surgery on salivary composition and cytomorphology of oral mucosa: follow-up three and six months	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2098	Impact of gastroplasty on salivary composition and cytomorphology of oral mucosa: follow-up three and six months	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2njhwn	<NULL>	The inclusion factors will be: young adults between the ages of 18 and 40, of both sexes, with indication of gastroplasty	The exclusion factors of the sample will be: diagnosis of chronic diseases such as epilepsy, cancer, rheumatoid arthritis; bucco-dentofacial diseases or trauma; use of tobacco or illicit drugs; Diseases that alter the quantity and quality of secreted saliva, such as Sjögren&apos;s syndrome, systemic lupus erythematosus and sarcoidosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-9jp5sj	Application of light at acupuncture points in the treatment of pain in children with sickle cell disease	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2099	Application of LASER acupuncture in the treatment of pain in children with sickle cell disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-06	Núcleo de Estudo em Saúde e Funcionalidade	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-9jp5sj	<NULL>	Patients with sickle cell disease confirmed by laboratory examination (falcization or hemoglobin electrophoresis test); report of joint pain in hematological consultation ; written proof of the authorization of the person responsible for inclusion in the study by signing a Free and Clarified Consent Term.	Previous history of fracture for a year or less, previous history of osteomyelitis, rheumatic fever, rheumatoid arthritis, leukemia, malignant neoplasm, child with cerebral palsy , making use of opioids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-7szm34	Impact of Early Mobilization on Sepsis Patients: influence of Passive and Active Exercises on the cardiovascular and inflammatory systems	Recruiting	Intervention	2018-08-06	<NULL>	<NULL>	2101	Impact of Early Mobilization in Sepsis Patients: influence of Exercise on endothelial function, cardiac autonomy and inflammatory profile	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7szm34	<NULL>	Clinical diagnosis of sepsis.	atrial fibrillation;pre-existing atrioventricular block or ventricular tachycardia; recent myocardial infarction (&lt;6 months);patients with pacemaker; stroke; signs of intracranial hypertension; cranioencephalic trauma; neuromuscular disease; Body mass index (BMI) greater than 40; patient with neoplasia undergoing chemotherapy and unconsolidated fracture.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-8bdqzd	Cancer frequency among children and adults carrying or not a hereditary mutation that facilitate Cancer development, taking into consideration the diversity of the rural or urban environment where they live	Recruiting	Observational	2018-08-07	<NULL>	<NULL>	2103	Neonatal Screening, Mapping of the TP53 R337H mutation prevalence per municipality, Cancer history, socioeconomic profile and molecular alterations associated with tumors in the families	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2010-02-01	Associação Hospitalar de Proteção à Infância Dr Raul Carneiro	Instituto de Pesquisa Pelé Pequeno Príncipe	https://ensaiosclinicos.gov.br/rg/RBR-8bdqzd	<NULL>	Newborn positive for mutation TP53 R337H; relatives of the positive newborn on the parental side who inherited the TP53 R337H mutation; both genders; age between 1 day and 120 years.	Relatives of the parental side who did not inherit the mutation TP53 R337H.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:26
RBR-4p6fk2	Physical exercise with limitation of blood flow to the forearm in renal patients: randomized clinical trial	Recruiting	Intervention	2018-08-09	<NULL>	<NULL>	2106	Efficacy of physical exercise with restriction of blood flow on the blood vessels of the forearm pre and post-confection of arteriovenous fistula in Chronic Kidney Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-31	Universidade Federal da Pernambuco	Universidade Federal da Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4p6fk2	<NULL>	The study will include patients with stage 4 or 5 chronic kidney disease; of both sexes, aged between 18 and 60 years; in conservativ treatment or dialysis; and who have medical indication for the manufacture of arteriovenous fistula for the performance of hemodialysis.	Those that present cognitive deficits that may interfere in the understanding of the evaluation process or the accomplishment of the activities will be excluded; patients with a history of arteriovenous fistula production in the upper limbs or who have undergone previous local vascular procedure; those that perform manual activity with high loads; and that presented traumatic-orthopedic injuries in cervical, shoulder, elbow, wrist and hand; and those with signs of thrombophlebitis and hypoplasia / agenesis of the upper limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-7sxmn7	Autologous Platelet-Rich Fibrin Membrane: new perspectivein the treatment of wounds in lower members	Recruiting	Intervention	2018-08-09	<NULL>	<NULL>	2107	Autologous Platelet-Rich Fibrin Membrane: new perspectivein the treatment of trophic lesions in lower members	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-18	Fundação Educacional da Região de Joinville-UNIVILLE	Fundação Educacional da Região de Joinville-UNIVILLE	https://ensaiosclinicos.gov.br/rg/RBR-7sxmn7	<NULL>	"Older than 18 years; both genders; voluntarily agree to participate; sign the
Term of Free and Informed Consent; present trophic lesions in lower limbs with more than 30 days duration; Wounds with 1cmx1cm at 8cmx8cm; not submitted to hyperbaric oxygen therapy."	"Trophic lesions of lower limbs smaller than 1cm x 1cm or larger
8cmx8cm; submitted to hyperbaric oxygen therapy; voluntary withdrawal at any time during the research"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-4ybjmt	Evaluation of therapies to reduce the sensitivity of teeth in dental lesions located near the gun	Recruiting	Intervention	2018-08-09	<NULL>	<NULL>	2109	Evaluation of desensitizing therapies in Non-carious cervical lesions - randomized clinical trial, double -blind	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de Brasília	Corpo de Bombeiros Militar do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-4ybjmt	<NULL>	Patients who present at least one LCNC with HDC; Both sexes; Age range: from 18 to 60 years; Do not have had home treatment in the last month with dentifrices / pastes / creams or mouthwashes indicated for the treatment of dentine hypersensitivity, having in their composition: potassium nitrate, oxalates, strontium, bicarbonate of arginine or 5000 ppm / F; Not having performed office treatment with desensitizing agents for professional use such as lacquer, gels and laser therapy in the last month; Do not use anti-inflammatory or analgesics during treatment	Patients with LCNC, but without HCD; Use of continuous anti-inflammatory and analgesic medications; Use of orthodontic appliance; Presence of periodontitis or active carious lesion; Pregnant or nursing; Continuously use toothpaste / paste / creams or mouthwashes indicated for the treatment of dentine hypersensitivity, having in their composition: potassium nitrate, oxalates, strontium, arginine bicarbonate or 5000 ppm / F; Very deep LCNCs being possible to visualize the shade of the pulp chamber, indicated restorative treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-463sk7	Follow-up of patients submitted to dental implant and prostheses rehabilitation	Recruiting	Observational	2018-08-10	<NULL>	<NULL>	2114	Longitudinal study of patients submitted to dental implant installation and implant retained prostheses	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-463sk7	<NULL>	To present dental absence (total or partial) that indicates the insertion of dental implant and posterior confection of dental prosthesis; To present good general state of health, that allows the accomplishment of the surgery of dental implant; Availability of time and time to attend dental appointments at the institution.	Systemic disease that prevents the accomplishment of the surgery; Unavailability to be treated at the institution.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-923s3w	Functional skills and caregiver assistance in children and adolescents with autism using virtual reality	Recruiting	Intervention	2018-08-15	<NULL>	<NULL>	2119	Characterization of functional abilities and caregiver assistance in children and adolescents with autism spectrum disorder submitted to virtual reality	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade de São Paulo Leste - Escola de Artes, Ciências e Humanidades	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES	https://ensaiosclinicos.gov.br/rg/RBR-923s3w	<NULL>	The signing of a free and informed consent by the parents or guardians of the minors; signature of the term of assent by the minor; mild and moderate degree diagnosed by a child neurologist and multidisciplinary team of the institution, will include people with autism who attend between 1st and 5th grade elementary school	Severe autism; comorbidities such as Attention Deficit Disorder with Hyperactivity and Down Syndrome; withdrawal during the protocol; functional deficiencies that impede the accomplishment of the task	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:27
RBR-5x762v	Vitamin A and Zinc Supplements in the Treatment of Visceral Leishmaniasis	Recruiting	Intervention	2018-08-17	<NULL>	<NULL>	2125	Effects of Supplementation with Vitamin A and Zinc in the Treatment of Visceral Leishmaniasis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Ministério da Educação	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)	https://ensaiosclinicos.gov.br/rg/RBR-5x762v	<NULL>	Adult patients of both genders and children of six months of age or more; presenting the following requisites: diagnostic of visceral leishmaniasis in treatment, made at the Natan Portela Institute for Tropical Diseases IDTNP in Teresina, Piaui, Brazil, located at Rua Governador Raimundo Artur de Vasconcelos 151 Sul.	Patients with hematological malignancies; patients undergoing chemotherapy; children under six months of age; pregnant women; children who have received vitamin A supplementation in the last six months; patients who are bedridden or to swallow.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-4x3cnp	"Implementation of HIV Pre-exposure Prophylaxis (PrEP) for men who have sex with men and transgender individuals at high risk for HIV infection: 
A Demonstration Project in the context of Combination Prevention in Brazil, Mexico and Peru"	Recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2129	"ImPrEP - Implementation of HIV Pre-exposure Prophylaxis (PrEP) for men who have sex with men and transgender individuals at high risk for HIV infection: 
A Demonstration Project in the context of Combination Prevention in Brazil, Mexico and Peru"	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-07	Instituto Nacional de Infectologia vandro Chagas (INI) - Fiocruz	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4x3cnp	<NULL>	"Male sex (at birth), except for transgender male; Willing and able to provide written informed consent; Age 18 years or older; HIV-1-uninfected defined as: Rapid HIV test negative at the enrollment visit; Evidence of risk for acquiring HIV-1 infection including any one of the following: a.	Condomless anal sex with male or transgender sex partners during the last 6 months; or b.	Anal sex with at least one HIV+ partner during the last 6 months; or c.	Reported rectal or urethral gonorrhea or chlamydia or syphilis in the 6 months prior to enrollment or diagnosed at enrollment; or d.	Reporting to exchange sex for money, gifts, shelter or drugs in the last 6 months; No previous history of renal disease."	Signs or symptoms of acute HIV infection; Creatinine clearance &lt; 60 ml/min as estimated by the Modification of Diet in Renal Disease (MDRD) formula; Previously diagnosed active and serious infections, including tuberculosis or osteomyelitis and all infections requiring parenteral antibiotic therapy (other than STIs requiring intramuscular injections of antibiotics); active clinically significant medical problems including poorly controlled cardiac disease (e.g., symptoms of ischemia, congestive heart failure), or previously diagnosed malignancy expected to require further treatment; History of pathological bone fractures not related to trauma; Receiving ongoing therapy with any of the following: ART, including nucleoside analogs, non-nucleoside reverse transcriptase inhibitors, protease inhibitors (except for antiretrovirals used for PEP) or investigational anti-retroviral agents, interferon (alpha, beta, or gamma) or interleukin (e.g., IL-2) therapy, agents with significant nephrotoxic potential, other agents that may inhibit or compete for elimination via active renal tubular secretion (e.g., probenecid), and/or other investigational agents; Concomitant participation in a clinical trial using investigational agents, including placebo-controlled clinical trials using such agents.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-3ys6h4	"Effect of a nutritional education program on 
patients with  genetic high cholesterol  quality of life"	Recruiting	Intervention	2018-08-20	<NULL>	<NULL>	2132	Effects of HIPERCOL program on patients with heterozygous Familial Hypercholesterolemia quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-03-19	Instituto Nacional de Cardiologia- INC	Instituto Nacional de Cardiologia- INC	https://ensaiosclinicos.gov.br/rg/RBR-3ys6h4	<NULL>	Patients with familial hypercholesterolemia genetic diagnosis performed by Brazilian`s Heart Institute (INCOR) e attending to cardiological treatment in National Institute of Cardiology-Brazil.	"Oral feeding difficulties;
clinical suspicion or diagnosis of hepatopathy and nephropathy in dialysis; oncological patients or patients undergoing gastroplasty; previous organ transplantation; wheelchair users; congestive heart failure; postoperative cardiac surgery (30 days); nutritional follow-up in the last 6 months."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-2zx53z	Study of Vitamin D and Statins on Vascular Function in hypertensive patients	Recruiting	Intervention	2018-08-21	<NULL>	<NULL>	2133	Study of Vitamin D and 3-Hidroximetilglutaril CoA redutase inhibitors administration on Endothelial Function and Renin-Angiotensin-Aldosterone system in patients with Hypertension: a double-blind placebo-controlled study	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2016-07-01	Unifesp - Universidade Federal de São Paulo	SBIAE - Sociedade Beneficente Israelita Brasileira Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-2zx53z	<NULL>	Volunteers with essential hypertension, without hypertension related organ damage. Between 18 and 75 years old.	Patients previously with: Diabetes mellitus; Autoimunne disease; Neurologic Degenerative disease; Calcium or phosphate metabolism disease; Clinical need of lipid lowering drug prescription. Beside these: Patients who refuse to sign in voluntary consent letter; Patients with severe Hypertension (Sys &gt; 180mmHg / Dias &gt;110mmHg); Patients with hypertensive organ related damage or patients with secundary hypertension diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-5f8xwb	Clinical and radiographic evaluation of the survival of the implants, conditions of the tissues around the implants and conditions associated with the effectiveness of treatment in patients rehabilitated with fixed lower denture on implants	Recruiting	Intervention	2018-08-21	<NULL>	<NULL>	2135	Clinical and radiographic evaluation of the survival of the implants, conditions of peri-implant tissues and conditions associated with the effectiveness of treatment in patients rehabilitated with full-arch mandibular fixed prostheses	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5f8xwb	<NULL>	Edentulous in both arches; Both sexes; All patients should have been rehabilitated with conventional dentures at the Federal University of Rio Grande do Norte; users of new conventional dentures, with at least two (2) months of use and a maximum of one (1) year.	Presence of these conditions: diabetes, smoking, osteoporosis and immunodeficiency; have undergone radiation therapy to the head and neck; be treated with some anticoagulant therapy; younger than 18 years; torque of the implant less than 45Ncm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-9s53kh	Evaluation of the Health of Bone and Soft Tissues around the implants of the patients who were treated with Implants and Removable or Fixed Prostheses on them	Recruiting	Intervention	2018-08-21	<NULL>	<NULL>	2136	Evaluation of Peri-plantar Health in patients rehabilitated with Overdentures and Fixed Implant Prosthesis.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2014-12-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9s53kh	<NULL>	Edentulous in both arches; Both sexes; All patients should have been rehabilitated with conventional dentures at the Federal University of Rio Grande do Norte; users of new conventional dentures, with at least two (2) months of use.	Presence of these conditions: diabetes, smoking, osteoporosis and immunodeficiency; have undergone radiation therapy to the head and neck; be treated with some anticoagulant therapy; younger than 18 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:28
RBR-5kj6n2	Development and Application of Educational Multimedia in oral health orientation in patients with use of teeth apparatus	Recruiting	Intervention	2018-08-23	<NULL>	<NULL>	2142	Development and Application of Educational Multimedia in oral health orientation in orthodontic patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-10	Universidade Federal de Sergipe	Atlântico Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-5kj6n2	<NULL>	Patients without orthodontic appliance or fixtures installed; above 18 years; access to a smartphone; without history of orthodontic treatment.	Patients with orthodontic appliance or fixed fittings installed; children under 18 years of age; without access to a smartphone; with a history of orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-5by938	Pregnant women with diabetes and oral health	Recruiting	Intervention	2018-08-23	<NULL>	<NULL>	2145	Workers Health: Pregnant women with diabetes and oral health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5by938	<NULL>	Pregnant women at any stage of gestation with diabetes mellitus	Pregnant women at any stage of pregnancy who do not have Diabetes Mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-878xgs	The importance of telephone counseling for the preparation of the Intestine Exam	Recruiting	Intervention	2018-08-23	<NULL>	<NULL>	2146	Impact of nurse orientation by telephone on the preparation of the Colonoscopy Examination	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-10-09	Departamento de Enfermagem da Faculdade de Medicina de Botucatu	UNESP _ Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-878xgs	<NULL>	"Inclusion: Patients attending the nursing consultation for orientation to the examination, 
Patients older than 18 years"	Patients who do not have a telephone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-6hxyft	Analysis of the whitening effect and sensitivity during dental whitening using the Violet Light: Clinical study	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2156	Analysis of bleaching and neurosensory efficacy of dental sensitivity during dental bleaching using Violet Light: A double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6hxyft	<NULL>	Vital and healthy upper teeth. Absence of dental caries. No visible defects of the enamel. Absence of orthodontic appliance. Good systemic conditions. Healthy oral soft tissues. Non smokers. Patients who have never performed bleaching treatment.	Conoid teeth. Direct and indirect restorations in the upper anterior region. Adverse reactions to peroxide. Use of opiates or drugs that influence the neurosensory response. Use of pacemaker. Presence of dental pigmentation (tetracycline, trauma, fluorosis and unknown etiology). Neurological diseases. Chronic or acute diseases. Dentinal exposure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-83xh37	Effects of Ziclague® (Alpinia zerumbet) in patients with hereditary spastic paraplegia	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2157	Ziclague® (Alpinia zerumbet) in patients with hereditary spastic paraplegia: randomized, double-blind, placebo-controlled and crossover clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-08-15	Universidade Estadual de Campinas (UNICAMP)	Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-83xh37	<NULL>	Age between 18 and 80 years old. Clinical diagnosis of Hereditary Spastic Paraplegia. Ability to walk out of home. Assistive devices are permitted	Wheelchair bound patients. Additional neurological symptoms that may significantly impact gait such as ataxia, lower motor neuron disease, polyneuropathy, mental retardation or dementia. Fixed tendon contractures. Current botulinum toxin injection or in the last six months. Pregnants or breastfeeding. Refusal to consent form. Skin infection or inflammation at site of interest.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:29
RBR-3npbf8	Evaluation of biological markers (psychological and physiological) after therapy to reeducate thinking and behavior in university students with Major Depressive Disorder.	Recruiting	Intervention	2018-08-31	<NULL>	<NULL>	2161	Evaluation of psychophysiological biomarkers after Cognitive-Behavioral Therapy in university students with Major Depressive Disorder.	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-03-05	Universidade Federal do Rio Grande do Norte	Faculdade de Medicina de Ribeirão Preto - FMRP-USP, Universidade de São Paulo (USP).	https://ensaiosclinicos.gov.br/rg/RBR-3npbf8	<NULL>	"Healthy volunteer (control) - No diagnostic or history of psychiatric disorders; age from 18 to 35 years and be a student of UFRN.


TDM patient - presence of current depressive episode, with mild or moderate grade; age from 18 to 35 years and be a student of UFRN."	"Healthy volunteer - Current diagnosis of clinical disease based on anamnesis and/or laboratory tests; present suicidal risk; diagnosis of Bipolar disorder, types I or II; show specific phobic symptoms for injection-blood-injury; presence or history of psychotic symptoms, mania or hypomania, induced or not by antidepressants or substance use; abuse or dependence on alcohol and other drugs; pregnancy.

TDM patient - present severe levels of depression (according to the Hamilton Depression Rating Scale (HAM-D) and / or the Montgomery and Asberg Depression Rating Scale (MADRS)); use psychiatric or neurological medications or drugs with effects on cognition, mood, and neurovegetative functions; be in treatment by psychotherapy; show diagnostic for others mental disorder in addition to major depression; present phobic specific symptoms of injection-blood-injury; pregnancy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-5xnjbc	Non-Invasive Brain Stimulation in the treatment of Pain due to brachial plexus injury	Recruiting	Intervention	2018-09-03	<NULL>	<NULL>	2165	Transcranial Magnetic Stimulation Versus Transcranial Direct Current Stimulation in the Treatment of Neuropathic Pain due Braquial Plexus Injury: A Randomized Pilot Study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-13	Programa de Pós-graduação em Neurociência Cognitiva e Comportamento	Instituto de Neurologia e Neurocirurgia da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5xnjbc	<NULL>	"Age over 18 years
Score of 4 to 10 points in the Scale for Pain Evaluation
Persistent pain and refractory to clinical treatment for at least 6 months
Appropriate pharmacological treatment for pain for at least 1 month before the start of the study"	"Patients with other neurological or psychiatric disorders, including major ongoing depression
Previous history of substance abuse
Contraindications for rTMS and / or tDCS"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-738wng	Effects of vibrations generated in oscillating / vibratory Platform in young and Healthy individuals	Recruiting	Intervention	2018-09-03	<NULL>	<NULL>	2166	Evaluation of the acute effects of vibrations generated in oscillating / vibratory Platform in young and Healthy individuals through functional parameters	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-06-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-738wng	<NULL>	Individuals over 18 years of age, both sexes, healthy	diagnosis of osteo-myocardial diseases; neurological disease that causes &quot;fear&quot; of the movements on the oscillating platform; clinical disease; at the discretion of the investigator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-4njb3p	Effect of therapeutic bath in pain, in sleep and vital sign in babies influenza in a semi-intensive therapy unit of university hospital in the south of Brazil	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2171	Effect of therapeutic bath in pain and physiological variables of infant influenza in a semi-intensive therapy unit of university hospital in the south of Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-18	UCPEL - Universidade Católica de Pelotas	UCPEL - Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-4njb3p	<NULL>	Neonates and infants hospitalized at the Neonatal Semi-Intensive Therapy Unit; with a life time of at least 72 hours, 1,250 grams; up to 6 months of age; which are parents or guardians agree to participate in the study.	clinically unstable preterm infants; contraindications to the immersion bath; new borns weighing less than 1,250 kg; infants who present temperature changes; need for ventilatory support; infectious process; neurological problems; facial congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-5pn79s	Effectiveness of speech therapy for the elderly with vocal alterations	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2172	Effectiveness of a Speech-Language Therapy Program for Presbyphonia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-26	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5pn79s	<NULL>	Individuals of both sexes, with 60 years of age or older, diagnosed with presbylarynx, with no previous history of vocal fold lesions or who have undergone laryngeal fioricrosurgery and / or who have a previous diagnosis of pneumopathy, heart disease or neurological disease, or other laryngeal changes associated with presbylarynx.	Individuals who have undergone previous speech therapy, do not have adherence to the proposed speech-language therapy; smokers, singers, who have cognitive and neurological alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-3qpr2n	Physiotherapy  treatment of vaginal stenosis and sexual dysfunction after brachytherapy	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2173	Impact of physiotherapy on quality of life and sexual function of women after locally advanced cervical cancer brachytherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Natalia Carion Haddad	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-3qpr2n	<NULL>	Female patients; aged between 18 and 65 years; in treatment for locally advanced cervical cancer (according to FIGO staging); who will undergo brachytherapy; and those who agreed to participate in the study	Patients with cognitive deficits, with distante metastases, with collagen diseases, pregnant women,  relapsing disease, residual disease reported in writing after the end of brachytherapy, submitted to a previous hysterectomy (partial or total), active condition of Venous Deep Thrombosis, cardiopulmonary disorders that limit ADLs, pacemaker patients, acute urogenital infection, genital prolapse, inability to stand up, phlebitis, embolism, advanced osteoporosis, epileptics, and those that lack any of the assessment steps.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-7w4szm	Analysis of the situation of Diabetes in the state of Espírito Santo and the actions developed by health professionals	Recruiting	Observational	2018-09-05	<NULL>	<NULL>	2174	Spatial analysis of Diabetes and evaluation of health practices developed: a contribution to health planning and decision making in the state of Espírito Santo, Brazil	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-05-01	Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, EMESCAM	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-7w4szm	<NULL>	Professionals working in the units for at least six months; users attended by professionals selected for at least six months; users with complications resulting from diabetes	Recent users in the unit; unregistered users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-8cnkwq	Evaluation of the effect of the school&apos;s prevention program to the use of drugs #Tamojunto2.0, version 2018	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2175	Effectiveness evaluation of the school&apos;s prevention program to the use of drugs of the Ministry of Health: # Tamojunto2.0, version 2018	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-25	Universidade Federal de São Paulo - UNIFESP	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8cnkwq	<NULL>	Being a student enrolled in grade 8 (old 7th grade) of one of the public schools randomly selected from the list of INEP, and consent to respond to the pre and post-test questionnaire.	Questionnaires without adequate codes; Students with cognitive impairment; Refusal in completing the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:30
RBR-26gmm3	Hidden Oclusal cavities in primary molars: use fluoride varnish, seal or restore.	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2177	Hidden Oclusal cavities in deciduous molares without obvious cavities: control, seal or restore	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-04	Universidade de Brasilia	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-26gmm3	<NULL>	We will select, through clinical and radiographic examination; children between 5 and 8 years of age who present primary molars with caries lesions CAST 4,;totalizing 75 teeth.	Molars with carious lesions that are radiographically located in the inner half of dentin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-3j7xk2	Relationship of visual alteration with posture and its influence on body pain	Recruiting	Intervention	2018-09-05	<NULL>	<NULL>	2179	Relationship of astigmatism with posture and its influence on body pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-02	Faculdade Alfredo Nasser	Faculdade Alfredo Nasser	https://ensaiosclinicos.gov.br/rg/RBR-3j7xk2	<NULL>	Aged between 18 and 59 years; medical diagnosis of astigmatism.	Individuals with musculoskeletal changes that may influence orientation and posture control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2mk2fn	White spot lesion treatment	Recruiting	Intervention	2018-09-06	<NULL>	<NULL>	2180	Light-­induced fluorescence images as evaluation of white spot lesion treatment in orthodontic patient	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-09-10	Faculdade de Odontolgia de Ribeirão Preto da USP	Faculdade de Odontolgia de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-2mk2fn	<NULL>	The following inclusion criteria will be adopted: absence of enamel hypoplasia or tetracycline pigmentation, not having used antibiotics in the 3 months prior to the study; not being on systemic medication, have not undergone periodontal treatment within 3 months prior to the start of the study, not being smokers, not be carriers of systemic disorders that could interfere with the periodontal condition, prior to the installation of the appliance, craniofacial anomalies.	Syndromic patients, deciduous dentition, patients with prosthesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-4kkq8c	Gel for the treatment of herpes lip lesions	Recruiting	Intervention	2018-09-10	<NULL>	<NULL>	2181	Evaluation of precursory gel of film containing on-site anesthetic for treatment of the herpes simplex: randomized, double-blind and controlled clinical study.	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2017-03-10	Faculdade De Odontologia de Ribeirão Preto	Faculdade De Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-4kkq8c	<NULL>	Legal or minor adult volunteers with accompanying legal guardians; both genders; without current treatment regimen against herpes.	Individuals in use or who used systemic-specific antiviral medication in the 15 days preceding the study;pregnant women;patients with heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-3n52h4	Movement analysis of individuals with knee arthosis submitted to treatment with intra-articular viscosupplementation	Recruiting	Intervention	2018-09-10	<NULL>	<NULL>	2185	Biokinetic analysis of individuals with knee osteoarthritis submitted to treatment with intra-articular viscosupplementation	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2017-10-01	Instituto Brasil de Tecnologias da Saúde	Hospital de Força Aérea do Galeão	https://ensaiosclinicos.gov.br/rg/RBR-3n52h4	<NULL>	Patients registered in the surgery waiting queue; older than 60 yo; able to walk ten meters independently; without external aid.	valgus or varus deformity higher than fifteen degrees; neurological impairment; indication for bilateral TKA; OA related to periarticular fracture or of septic origin; who have functional limitations in ankle or ipsilateral hip as a result of prior trauma; who do not agree with the consent terms to the research; who refuse to receive the articular infiltrations or perform biomechanical tests; who have no autonomy to raise, sit and/or walk without assistance from other people; illiterate individuals or those who are unable to answer independently the IKDC and LEFS questionnaires; who have used in the last six months or at any time during the study period corticosteroid drugs or surgery in the affected limb.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-6zfy89	Quality management: control of unplanned extubation in children admitted to a pediatric intensive care unit	Recruiting	Observational	2018-09-12	<NULL>	<NULL>	2189	Quality management: control of unplanned extubation of pediatric patients in a pediatric intensive care unit	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Hospital de Clínicas da Universidade Federal do Praná	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-6zfy89	<NULL>	Patients of both genders; with ages ranging from 28 days to 14 years; intubated and mechanically ventilated; admitted to the Pediatric ICU; with an informed consent form signed by a parent or guardian.	Tracheostomized patients; pacients  with noninvasive mechanical ventilation; did not sign the Informed Consent Term pacients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-3vybj7	Classification of intensive care center patients according to the workload for Physiotherapy	Recruiting	Observational	2018-09-12	<NULL>	<NULL>	2190	Classification of intensive care unit patients according to the workload for Physiotherapy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-06-22	Hospital Universitário da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3vybj7	<NULL>	Physiotherapy session of patients admitted to the adult intensive care unit of the University Hospital of University of São Paulo	Interrupted physiotherapy session; compromised data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-5jv4qs	Effects of Magnesium on Endothelium in Hypertensive	Recruiting	Intervention	2018-09-13	<NULL>	<NULL>	2194	Effects of Magnesium on Endothelial Function in Hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-27	Hospital Universitário Pedro Ernesto	Universidade do Estado do Rio de Janeiro - UERJ	https://ensaiosclinicos.gov.br/rg/RBR-5jv4qs	<NULL>	"Outpatient patients between the ages of 40 and 65 years.
Both genders, with postmenopausal women.
Hypertensive patients with systolic blood pressure greater than or equal to 140 mmHg and / or diastolic blood pressure greater than or equal to 90 mmHg.
In pharmacological treatment, with stable use of at least two antihypertensive classes in the last four weeks.
Patient with body mass index less than or equal to 35 kg / m2.
Patients with habitual food consumption maintained for at least four weeks.
Signature of the Informed Consent Term (SICT)."	"Smoking.
Diabetes Mellitus.
Hormone replacement therapy.
Hypertension with blood pressure greater than 160/100 mmHg.
Use of beta-blocker or statin.
Evidence of secondary hypertension.
Changes in thyroid function, chronic renal and liver diseases.
Clinically evident coronary disease with prior history of acute myocardial infarction and / or myocardial revascularization, with clinical signs of heart failure, symptomatic cardiac arrhythmia, or clinically significant valve disease, prior cerebrovascular accident.
Use of nutritional supplements (vitamins, minerals) for up to seven days before the start of the study.
Patients presenting with any serious illness and any condition, illness or therapy that, in the opinion of the investigator, may impair the results, interfere with the study objectives or jeopardize patient safety."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:31
RBR-2sdy28	Probiotics use for gum disease treatment	Recruiting	Intervention	2018-09-14	<NULL>	<NULL>	2197	Probiotics use in periodontal diseases treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-10	Universidade Veiga de Almeida	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-2sdy28	<NULL>	Volunteers must present Periodontitis; presence of probing pocket depth &gt; 3 mm in association with clinical attachment loss &gt; 3 mm in at least 2 sites of 2 non-adjacent teeth; They must also present more than 20 teeth; age between 30 to 70 years old.	Cigarete smokers; history of previous periodontal treatment; antibiotics use within the past 6 months; pregnancy; presence of acute or necrotizing lesions; history of diabetes; rheumatic fever; neurological deficiencies; immunological diseases; use of medications that affect periodontal tissues such as phenytoin, cyclosporine, nifedipine and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-5hdw4d	Observation by ultrasound examination of variation of a belly vein during breathing in pediatric patients	Recruiting	Observational	2018-09-14	<NULL>	<NULL>	2199	Ultrasonographic evaluation of respiratory variation of the inferior vena cava in pediatric patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-09-05	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-5hdw4d	<NULL>	Children between 28 days and 14 years; admitted to the Unicamp Hospital das Clínicas; both sexes	Psychomotor agitation; respiratory distress; lesions or bandages on the abdominal region that make ultrasound examination impossible will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-8s2nbf	Effect of the nintendo wii sport video game on rehabilitation of the arms of patients with post polio syndrome: Application research, security and acceptance of the game	Recruiting	Intervention	2018-09-15	<NULL>	<NULL>	2200	Effects of the nintendo wii Sports interactive video game on the motor function of upper limbs of individuals with post polio syndrome: randomized clinical trial of applicability, safety, acceptability	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8s2nbf	<NULL>	Patients diagnosed with SPP established by the consensus of Healsted &amp; Rossi (1985), patients who are not performing rehabilitation and or physical exercise during the application of the treatment protocol, patients with muscle strength greater than or equal 3 on shoulders and elbows	Patients unable to commit to the established protocol of 14 virtual reality therapy sessions, patients presenting shoulder anterior and or inferior subluxation clinically assessed by palpation greater than or equal to 2 fingers,patients with deformities in the upper limbs that make it impossible to train with the videogame	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-3cqbw8	Effect of the shape of the posterior teeth on the satisfaction, quality of life and mastication of users of dentures	Recruiting	Intervention	2018-09-17	<NULL>	<NULL>	2204	Impact occlusal surfaces of posterior teeth in satisfaction, quality of life and masticatory efficiency of complete denture wearers bimaxillary	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-19	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3cqbw8	<NULL>	Volunteers should be in good general health; both genders; absence of intraoral lesions and alteration of the perioral musculature detected by palpation; as well as signing the Free and Informed Consent Form. Edentulous individuals less than 5 years old will not be included in the sample.	Those who have given up part of the survey; were in poor health; unable to attend to where the search is performed.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-25x5dn	Clinical reasoning skills for physical therapy students	Recruiting	Intervention	2018-08-28	<NULL>	<NULL>	2205	Teaching clinical reasoning skills to physical therapy students: a controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-09-15	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-25x5dn	<NULL>	Physiotherapy course students enrolled in the new curriculum (which includes Integrated Practical Activities)	Students who are not enrolled in the new curriculum of physiotherapy course  which includes the discipline of Integrative Practical Activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-8ptbqn	Study of andiroba oil in the healing of mucositis	Recruiting	Intervention	2018-09-17	<NULL>	<NULL>	2206	Evaluation of anti-inflammatory, cicatricial and toxicological activities of andiroba oil - carapa guianensis aubl (meliceae) on oral mucosite in patients submitted to quimioterpia	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2018-05-10	Universidade Federal do Pará	Hospital Ophir Loyola	https://ensaiosclinicos.gov.br/rg/RBR-8ptbqn	<NULL>	Have clinical signs of induced oral mucositis; age equal to or greater than 18 years; complete consciousness; with no history of radiotherapy; not receiving systemic antibiotics and antifungal drugs nor mouthwash during the study	Being under 18 years of age, having undergone radiation therapy and taking antifungal drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-2rcm2g	Safety of different doses of the antimalarial drug Primaquine on Vivax Malaria Treatment in patients Deficient of the enzyme Glucose-6-phospate Dehydrogenase	Recruiting	Intervention	2018-02-07	<NULL>	<NULL>	2208	Safety and efficacy of different regimens of Primaquine on Vivax Malaria treatment in Glucose-6-phospate Dehydrogenase Deficient patients admitted at the Fundação De Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-07-18	Fundação de Medicina Tropical Heitor Vieira Dourado - FMTHVD	Fundação de Medicina Tropical Heitor Vieira Dourado - FMTHVD	https://ensaiosclinicos.gov.br/rg/RBR-2rcm2g	<NULL>	Inclusion criteria: Male and female patients; older than 6 months of age; diagnosed with uncomplicated vivax malaria; with enzymatic activity between 10-60%	Exclusion criteria: Patients with severe malaria; hemoglobin levels below 9 g/dL; pregnant or breastfeeding females; children less than 6 months old; with severe enzymatic deficiency (enzymatic activity less than 10%); nephropathy; hepatopathy; under the use of potentially hemolytic drugs specified in the project; under the use of antimalarial drugs until two weeks before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-74snst	Mobile application as a means for pregnant women to participate in all pre-natal consultations	Recruiting	Intervention	2018-09-18	<NULL>	<NULL>	2213	Mobile application as a tool for adherence of pregnant women to prenatal care.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-05	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-74snst	<NULL>	pregnant women from 15 years of age; be attended at the Basic Unit of Health of choice for the study; have cognitive ability to participate in the research; know how to read; have a smartphone that supports the application and have access to the internet.	Pregnant women from the third trimester of gestation and who are not registered in the Basic Health Unit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-37428y	Effect of myofascial massage on voice, breathing and body posture of female teachers - randomized controlled clinical trial	Recruiting	Intervention	2018-09-19	<NULL>	<NULL>	2215	Effects of Myofascial Release Therapy on voice, breathing and body posture of teachers with Musculoskeletal and Vocal complaints: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Pós Graduação Distúrbios da Comunicação Humana da Universidade Federal de Santa Maria	Universidade Federal de Santa Maria - UFSM	https://ensaiosclinicos.gov.br/rg/RBR-37428y	<NULL>	active teachers at all levels of education; in the age group of 19 to 60 years; with normal larynx or the following laryngeal (LA) conditions: triangular crevice of degree I or degree II; presence of musculoskeletal and / or vocal complaints.	professor of Brazilian Language of Signs, support rooms, singing and or music; Physical Education or in administrative activities; history of neurological, gastric, psychiatric, endocrinological, rheumatic, musculoskeletal, degenerative or pulmonary diseases; Hearing Loss; orthopedic trauma or craniofacial malformations, whiplash injury, neck surgical scars, radiotherapy and laryngeal surgery; under phonoaudiological, physiotherapeutic and / or otorhinolaryngological treatment; amateur or professional singer; habits of alcoholism and / or smoking; diagnosis of dysphonia or other AL.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-8ttw3f	Association between Midazolam and Ketamine compared to Midazolam as sedative in Autistic patients that will be submitted to odontological treatment under general anesthesia	Recruiting	Intervention	2018-09-20	<NULL>	<NULL>	2218	Association between Midazolam and Ketamine as preanesthetic medication in patients with Autistic Spetrum Disorder submitted to odontological treatment under general anesthesia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Hospital Alberto Rassi- HGG	Hospital Alberto Rassi- HGG	https://ensaiosclinicos.gov.br/rg/RBR-8ttw3f	<NULL>	Autistic disorder; dental treatment; general anestesia; physical condition ASA I and II	Lack of consent, cardiac diseases, prediction of difficult airway, renal disease, alergy or previous adverse reaction to medications of the study, impossibility to give the medication completely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:32
RBR-26gq5n	IONTOFORESE IN LATERAL EPICONDYLITIS OF ELBOW	Recruiting	Intervention	2018-09-24	<NULL>	<NULL>	2225	Effect of the Iontophoresis in the Lateral Elbow Epicondylites: a double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-26gq5n	<NULL>	Have signed the informed consent form (TCLE); clinical diagnosis of lateral elbow epincondylalgia (ELC), uni- or bilateral; have not received any kind of treatment.	Shoulder, neck (radiculopathy) and / or thoracic region dysfunction; local or generalized arthritis; neurological deficit; trapping of the radial nerve; limitations in arm functions; Have received conservative treatment for ELC within four weeks before entering the study; neoplasia diagnosed at the treatment site; patient with a history of adverse reaction or hypersensitivity to electrical stimulation; contraindications to the medication to be administered; pain or symptoms of unknown origin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-93hyn7	Goal-directed training to the level of trunk control and reaching in preterm infants	Recruiting	Intervention	2018-09-24	<NULL>	<NULL>	2226	Effect of goal-directed training to the level of trunk control and reaching in preterm infants at the onset of reaching ability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-05-15	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-93hyn7	<NULL>	Extreme preterm infants with hospital discharge and low birth weight; very preterm and preterm infants moderately and late with adequate weight for gestational age, between the 10th and ninety percentile in the growth curve; both genders; age between four and six months; perform at least one and at most three ranges for one minute at the home visit.	Infants who are born with gestational age equal to or greater than 37 weeks; congenital central nervous system; signs neurological; musculoskeletal; genetic syndromes or symptoms of withdrawal symptoms associated with maternal report of abuse of alcohol and drugs; congenital infections; sensory deficits; cardiopulmonary difficulties or whose mothers have submitted episode of eclampsia or preeclampsia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-3tq6y3	The Effectiveness of Pharyngeal Expansion Surgery Compared to Tonsil and Adenoid Removal Surgery for Treatment of Obstructive Sleep Apnea in Obese Children	Recruiting	Intervention	2018-09-24	<NULL>	<NULL>	2228	The efficacy of Modified Expansion Pharyngoplasty compared to Adenotonsillectomy for treatment of OSAS in obese children	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital Estadual de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-3tq6y3	<NULL>	age between 3 and 12 years old; mild to severe obstructive sleep apnea in polysomnography; child obesity (BMI greater than p95)	Age younger than3 and older than 12 years old; syndromic patients, with craniofacial alteration or neuropsychomotor impairment, patients with asthma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-395mfw	Effects of Resistance Training with Blood Flow Restriction on muscle strength, mass, and quality of life of Cirrhotic patients	Recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2232	Resistance Training with Blood Flow Restriction in Cirrhotic patients: effects on strength, muscle mass, functionality and quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-17	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Cleiton Augusto Libardi	https://ensaiosclinicos.gov.br/rg/RBR-395mfw	<NULL>	Liver cirrhosis confirmed through histopathological assessment, hepatic elastography, or clinical, radiological or endoscopic criteria	Active alcohol intake in the previous 6 month; MELD score above 15; Child-Pugh class C; decompensated chronic diseases; diabetes mellitus; hepatocellular carcinoma or other neoplasms; previous liver transplantation;  severe ascites; persistent hepatic encephalopathy; clotting disorders characterized by INR superior to 1.5 or platelets inferior to 75,000; medical contraindication exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-9j3d9z	Study on Nasal Irrigation with Corticosteroid in patients with Chronic Sinusitis	Recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2233	"Nasal Irrigation with Corticostheroid in
Chronic Rhinosinusitis with nasal polyps:
randomized  clinical trial"	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-9j3d9z	<NULL>	Older than 18 years; chronic rhinosinusitis with nasosinusal polyposis; endoscopic nasosinusal surgery for at least 6 months; partially controlled or uncontrolled using corticosteroid nasal spray.	Refusal to participate in the study or to sign the ICF; inability to answer the questionnaires of the present study; pregnant or nursing mothers; absolute contraindication to EC use; prior diagnosis of immunodeficiencies; previous diagnosis of nasosinusal neoplasias; previous diagnosis of primary ciliary dyskinesias; previous diagnosis of cystic fibrosis; use, within 30 days prior to inclusion in the study, of oral, intramuscular or intravenous EC; use, during the study period, of oral, intramuscular or intravenous EC; nasal endoscopy evidencing an important block of the middle meatus (or nasal cavity) by polyp, edema or synechia, which does not permit visualization of the sinuses operated.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-92kmkf	Time-Response of Photobiomodulation by LEDS  On Muscular Performance	Recruiting	Intervention	2018-09-25	<NULL>	<NULL>	2236	Time response by Photobiomodulation (Light-Emitting Diodes) on Muscular Performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-04	Universidade do Sagrado Coração	Universidade do Sagrado Coração	https://ensaiosclinicos.gov.br/rg/RBR-92kmkf	<NULL>	Male; young adults; 18-30 years; healthy; BMI 18-30 kg / m²; physically active	History of cancer in the region of the upper limbs; infection; neurological deficits; musculoskeletal lesions in the shoulder; elbow; wrist or hand before the study (6 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-94r9wx	Does the high level of physical activity protect the human body against the negative effects of sleep deprivation?	Recruiting	Intervention	2018-09-26	<NULL>	<NULL>	2238	Sleep deprivation responses on cardiovascular measures in young people with different levels of physical activity submitted to a high-intensity interval exercise session	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-18	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-94r9wx	<NULL>	Low or high level of physical activity; without sleep disorders; habitual sleep of 7 to 8 hours per night; free from chronic degenerative diseases; no change in electrocardiogram at rest or during exercise; not using cardiovascular or psychotropic or vasoactive medications; present body mass index 30 kg per m2	No smoking or ex-smoker; do not consume more than 2 servings per day of alcohol; do not take coffee-type sympathomimetics or stimulants or alcohol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-6yf4cv	Evaluation of the effectiveness of Propolis associated with Pomegranate in Treatment of the Buccal Inflammation due denture use in elderly	Recruiting	Intervention	2018-09-26	<NULL>	<NULL>	2240	Evaluation of the effectiveness of Propolis associated with Pomegranate in the Denture Stomatitis Treatment in elderly	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2018-07-11	Hospital Universitário de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6yf4cv	<NULL>	"60 years or older
Use of partial or total dental prosthesis with palatal coverage
Present denture stomatitis"	"Recent use of antibiotic or antifungal (2 months at least before the recruitment)
Cognitive decline or dementia"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-99xnc6	Effects of physical training associated with word memorization in improving the balance of the elderly	Recruiting	Intervention	2018-09-27	<NULL>	<NULL>	2243	Effects of Cognitive motor training on postural control of the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-99xnc6	<NULL>	Elderly in the community aged 60 years or over; both sexes; functional state capable of remaining in the orthostatic position and walking without assistance; without cognitive impairment Mini Mental State Examination above 18 for illiterate and below 26 for those with educational level above 8 years; normal or corrected auditory acuity through the Whisper Test;normal or corrected visual acuity assessed by the Snellen Test; without prior experience with the Kinect Adventures system games and sign the Free and Informed Consent Form.	Neurological and orthopedic diseases; the inability to remain in a standing position or walk without assistance; cardiorespiratory diseases that result in clinical alterations; angina; cardiac insufficiency; decompensated blood pressure; behavioral alterations that interfere with the development of the study; incapacitating pain; a history of seizures; and missing more than three consecutive sessions without replacement.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:33
RBR-68y7cz	How to practically adjust artificial ventilation to protect the lungs during stomach reduction surgery.	Recruiting	Intervention	2018-09-28	<NULL>	<NULL>	2248	Evaluation of Strategies for Positive Pressure Rapid Adjustment at the End of Expiration in Laparoscopic Surgery with pneumoperitoneum in Obese patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-17	Hospital Federal dos Servidores do Estado	Instituto de Biofísica Carlos Chagas Filho- UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-68y7cz	<NULL>	Will be selected for the present study adult patients with obesity class III with BMI&gt; 40 kg / m2; more than 18 years old followed by the  bariatric surgery and endocrinology services of the Servidores do Estado do Rio de Janeiro Federal Hospital and will perform bariatric surgery.	Patients or legal guardians who do not agree to participate in the study or do not authorize the participation of patients under their responsibility will be excluded from the study; patients who have not signed the term of free and informed consent before the procedure; patients with diagnosed lung disease; patients with diagnosed heart failure; patients with chest wall alterations with different cause by obesity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-7fk9ww	Influence of core muscles in women with patellofemoral pain syndrome	Recruiting	Intervention	2018-10-01	<NULL>	<NULL>	2252	Influence of core muscles in women with patellofemoral pain syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-06	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7fk9ww	<NULL>	retropatellar or anterior knee pain during at least two of the following activities: sitting for an extended time, climbing stairs, crouching, running, kneeling, and jumping; pain during patellar palpation; symptoms for at least 1 month, insidious onset and unrelated to the traumatic accident; pain level at least 3 on a visual analogue scale of 10cm, in the last week; More than 3 positive of the following clinical signs: Clarke test, McConnell test, Waldron test, Zohler test, upper Q test greater than 18 degrees, Noble compression test, lateral or medial patella positioning; women aged between 18 and 35 years; Ability to perform normally as activities of daily living.	Other specific knee conditions such as gonarthrosis, ligament injury, meniscus injury, patellar tendon injury, joint degeneration, osteoarthritis or referred pain from the spine; knee surgery; history of patellar displacement or subluxation; knee treatments such as arthroscopy, use of anti-inflammatories, analgesics, anesthetics, acupuncture or physiotherapy during the last 6 months; presence of neurological diseases and inflammatory processes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:18:34
RBR-8w35rx	Effects of an exercise protocol in standing over sedentary lifestyle of frail elderly	Recruiting	Intervention	2018-10-02	<NULL>	<NULL>	2256	Effects of an exercise protocol in orthostatism over sedentary behavior of frail elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-15	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP